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Janet L. Paulsen, Ph.D. - Publications

Affiliations: 
2012 Pharmaceutical Sciences University of Connecticut, Storrs, CT, United States 
Area:
X-Ray crystallography, Structural biology, Molecular modeling, Structure-based drug design
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12 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Leidner F, Kurt Yilmaz N, Paulsen J, Muller YA, Schiffer CA. Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease. Journal of Chemical Theory and Computation. PMID 29570286 DOI: 10.1021/Acs.Jctc.8B00097  0.359
2018 Khan SN, Persons JD, Paulsen JL, Guerrero M, Schiffer CA, Kurt-Yilmaz N, Ishima R. Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance. Biochemistry. PMID 29457713 DOI: 10.1021/Acs.Biochem.7B01238  0.409
2017 Paulsen JL, Leidner F, Ragland DA, Kurt Yilmaz N, Schiffer CA. Interdependence of Inhibitor Recognition in HIV-1 Protease. Journal of Chemical Theory and Computation. PMID 28358514 DOI: 10.1021/Acs.Jctc.6B01262  0.433
2015 Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE. Structure-guided design of a high affinity inhibitor to human CtBP. Acs Chemical Biology. 10: 1118-27. PMID 25636004 DOI: 10.1021/Cb500820B  0.45
2014 Cai Y, Myint W, Paulsen JL, Schiffer CA, Ishima R, Kurt Yilmaz N. Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease. Journal of Chemical Theory and Computation. 10: 3438-3448. PMID 25136270 DOI: 10.1021/Ct4010454  0.308
2014 G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC. Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata. Journal of Medicinal Chemistry. 57: 2643-56. PMID 24568657 DOI: 10.1021/Jm401916J  0.557
2013 Paulsen JL, Viswanathan K, Wright DL, Anderson AC. Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species. Bioorganic & Medicinal Chemistry Letters. 23: 1279-84. PMID 23375226 DOI: 10.1016/J.Bmcl.2013.01.008  0.594
2011 Paulsen JL, Bendel SD, Anderson AC. Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity. Chemical Biology & Drug Design. 78: 505-12. PMID 21726415 DOI: 10.1111/J.1747-0285.2011.01169.X  0.588
2011 Algul O, Paulsen JL, Anderson AC. 2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition. Journal of Molecular Graphics & Modelling. 29: 608-13. PMID 21146434 DOI: 10.1016/J.Jmgm.2010.11.004  0.585
2009 Paulsen JL, Anderson AC. Scoring ensembles of docked protein:ligand interactions for virtual lead optimization. Journal of Chemical Information and Modeling. 49: 2813-9. PMID 19950979 DOI: 10.1021/Ci9003078  0.523
2009 Paulsen JL, Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans. Bioorganic & Medicinal Chemistry. 17: 4866-72. PMID 19560363 DOI: 10.1016/J.Bmc.2009.06.021  0.586
2008 Blauvelt ML, Khalili M, Jaung W, Paulsen J, Anderson AC, Brian Wilson S, Howell AR. Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation. Bioorganic & Medicinal Chemistry Letters. 18: 6374-6. PMID 18993065 DOI: 10.1016/J.Bmcl.2008.10.086  0.459
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