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Filip Van Petegem, Ph.D. - Publications

Affiliations: 
Biochemistry and Molecular Biology University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
voltage-gated sodium and calcium channels, Ryanodine Receptors
Website:
http://crg.ubc.ca/VanPetegem/
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65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chen YS, Garcia-Castañeda M, Charalambous M, Rossi D, Sorrentino V, Van Petegem F. Cryo-EM investigation of ryanodine receptor type 3. Nature Communications. 15: 8630. PMID 39366997 DOI: 10.1038/s41467-024-52998-9  0.41
2024 Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff RG. Propofol binds and inhibits skeletal muscle ryanodine receptor 1. British Journal of Anaesthesia. PMID 39304470 DOI: 10.1016/j.bja.2024.06.048  0.357
2024 Collaço RC, Van Petegem F, Bosmans F. ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents. The Journal of General Physiology. 156. PMID 39042091 DOI: 10.1085/jgp.202413563  0.337
2024 Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff RG. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1). Biorxiv : the Preprint Server For Biology. PMID 38260485 DOI: 10.1101/2024.01.10.575040  0.426
2023 Šeflová J, Schwarz JA, Smith AN, Svensson B, Blackwell DJ, Phillips TA, Nikolaienko R, Bovo E, Rebbeck RT, Zima AV, Thomas DD, Van Petegem F, Knollmann BC, Johnston JN, Robia SL, et al. RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET. Acs Chemical Biology. PMID 37769131 DOI: 10.1021/acschembio.3c00376  0.385
2023 Haji-Ghassemi O, Chen YS, Woll K, Gurrola GB, Valdivia CR, Cai W, Li S, Valdivia HH, Van Petegem F. Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Science Advances. 9: eadf4936. PMID 37224245 DOI: 10.1126/sciadv.adf4936  0.399
2023 Cholak S, Saville JW, Zhu X, Berezuk AM, Tuttle KS, Haji-Ghassemi O, Alvarado FJ, Van Petegem F, Subramaniam S. Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure (London, England : 1993). PMID 37192614 DOI: 10.1016/j.str.2023.04.009  0.397
2022 Chen YS, Van Petegem F. Structural and functional conservation of the activating Ca binding site in inositol 1,4.5-trisphosphate and ryanodine receptors. Cell Calcium. 108: 102671. PMID 36370621 DOI: 10.1016/j.ceca.2022.102671  0.457
2022 Rayani K, Hantz ER, Haji-Ghassemi O, Li AY, Spuches AM, Van Petegem F, Solaro RJ, Lindert S, Tibbits GF. The effect of Mg on Ca binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants. The Febs Journal. PMID 35838319 DOI: 10.1111/febs.16578  0.463
2022 Willegems K, Eldstrom J, Kyriakis E, Ataei F, Sahakyan H, Dou Y, Russo S, Van Petegem F, Fedida D. Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277. Nature Communications. 13: 3760. PMID 35768468 DOI: 10.1038/s41467-022-31526-7  0.334
2022 Qin J, Zhang J, Lin L, Haji-Ghassemi O, Lin Z, Woycechowsky KJ, Van Petegem F, Zhang Y, Yuchi Z. Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife. 11. PMID 35297759 DOI: 10.7554/eLife.75346  0.336
2022 Yang ZF, Panwar P, McFarlane CR, Tuinte WE, Campiglio M, Van Petegem F. Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations. Proceedings of the National Academy of Sciences of the United States of America. 119: e2120416119. PMID 35238659 DOI: 10.1073/pnas.2120416119  0.336
2021 Zhang J, Singh DP, Ko CY, Nikolaienko R, Wong King Yuen SM, Schwarz JA, Treinen LM, Tung CC, Rožman K, Svensson B, Aldrich CC, Zima AV, Thomas DD, Bers DM, Launikonis BS, ... Van Petegem F, et al. Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. The Journal of Biological Chemistry. 101412. PMID 34793835 DOI: 10.1016/j.jbc.2021.101412  0.39
2021 Woll KA, Van Petegem F. Calcium Release Channels: Structure and Function of IP3 Receptors and Ryanodine Receptors. Physiological Reviews. PMID 34280054 DOI: 10.1152/physrev.00033.2020  0.516
2021 Rufenach B, Van Petegem F. Structure and function of STAC proteins: Calcium channel modulators and critical components of muscle excitation-contraction coupling. The Journal of Biological Chemistry. 297: 100874. PMID 34129875 DOI: 10.1016/j.jbc.2021.100874  0.528
2021 Rayani K, Seffernick J, Li AY, Davis JP, Spuches AM, Van Petegem F, Solaro RJ, Lindert S, Tibbits GF. Binding of calcium and magnesium to human cardiac Troponin C. The Journal of Biological Chemistry. 100350. PMID 33548225 DOI: 10.1016/j.jbc.2021.100350  0.428
2021 Woll KA, Haji-Ghassemi O, Van Petegem F. Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM. Nature Communications. 12: 807. PMID 33547325 DOI: 10.1038/s41467-021-21141-3  0.352
2020 Genovese I, Giamogante F, Barazzuol L, Battista T, Fiorillo A, Vicario M, D'Alessandro G, Cipriani R, Limatola C, Rossi D, Sorrentino V, Poser E, Mosca L, Squitieri F, Perluigi M, ... ... van Petegem F, et al. Sorcin is an early marker of neurodegeneration, Ca dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases. Cell Death & Disease. 11: 861. PMID 33060591 DOI: 10.1038/s41419-020-03063-y  0.318
2020 Rufenach B, Christy D, Flucher BE, Bui JM, Gsponer J, Campiglio M, Van Petegem F. Multiple Sequence Variants in STAC3 Affect Interactions with Ca1.1 and Excitation-Contraction Coupling. Structure (London, England : 1993). PMID 32492370 DOI: 10.1016/J.Str.2020.05.005  0.442
2020 Holt C, Hamborg L, Lau K, Brohus M, Sørensen AB, Larsen KT, Sommer C, Van Petegem F, Overgaard MT, Wimmer R. The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-domain, altering its interaction with the cardiac ryanodine receptor. The Journal of Biological Chemistry. PMID 32317284 DOI: 10.1074/Jbc.Ra120.013430  0.487
2020 Stringer RN, Jurkovicova-Tarabova B, Huang S, Haji-Ghassemi O, Idoux R, Liashenko A, Souza IA, Rzhepetskyy Y, Lacinova L, Van Petegem F, Zamponi GW, Pamphlett R, Weiss N. A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Ca3.2 T-type channel activity. Molecular Brain. 13: 33. PMID 32143681 DOI: 10.1186/S13041-020-00577-6  0.439
2020 Wang K, Brohus M, Holt C, Overgaard MT, Wimmer R, Van Petegem F. Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca binding and cause misfolding. The Journal of Physiology. PMID 32012279 DOI: 10.1113/Jp279307  0.54
2020 Asghari P, Scriven DR, Ng M, Panwar P, Chou KC, van Petegem F, Moore ED. Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification. Elife. 9. PMID 31916935 DOI: 10.7554/eLife.51602  0.313
2020 Van Petegem F, Tung C, Gardill B, Rivera-Acevedo RE. Crystal Structures of Calcium-Loaded Calmodulin in Complex with C-Terminal Domains of Voltage-Gated Sodium Channels Biophysical Journal. 118: 576a. DOI: 10.1016/j.bpj.2019.11.3128  0.373
2019 Van Petegem F, Gardill BR. Reply to Pitt and Lee: Occupancies of Ca in complexes of calmodulin with voltage-gated sodium channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 31796598 DOI: 10.1073/pnas.1918159116  0.486
2019 Van Petegem F. Slaying a giant: Structures of calmodulin and protein kinase a bound to the cardiac ryanodine receptor. Cell Calcium. 83: 102079. PMID 31522075 DOI: 10.1016/j.ceca.2019.102079  0.346
2019 Ng LCT, Zhuang M, Van Petegem F, Li YX, Accili EA. Binding and structural asymmetry governs ligand sensitivity in a cyclic nucleotide-gated ion channel. The Journal of General Physiology. PMID 31481514 DOI: 10.1085/jgp.201812162  0.318
2019 Haji-Ghassemi O, Yuchi Z, Van Petegem F. The Cardiac Ryanodine Receptor Phosphorylation Hotspot Embraces PKA in a Phosphorylation-Dependent Manner. Molecular Cell. PMID 31078384 DOI: 10.1016/j.molcel.2019.04.019  0.323
2019 Gardill BR, Rivera-Acevedo RE, Tung CC, Van Petegem F. Crystal structures of Ca-calmodulin bound to Na C-terminal regions suggest role for EF-hand domain in binding and inactivation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31072926 DOI: 10.1073/pnas.1818618116  0.552
2019 Brohus M, Søndergaard MT, Wayne Chen SR, van Petegem F, Overgaard MT. Ca-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains. The Biochemical Journal. 476: 193-209. PMID 30530841 DOI: 10.1042/BCJ20180545  0.545
2018 Wang K, Holt C, Lu J, Brohus M, Larsen KT, Overgaard MT, Wimmer R, Van Petegem F. Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348784 DOI: 10.1073/Pnas.1808733115  0.511
2018 Pancaroglu R, Van Petegem F. Calcium Channelopathies: Structural Insights into Disorders of the Muscle Excitation-Contraction Complex. Annual Review of Genetics. PMID 30208288 DOI: 10.1146/annurev-genet-120417-031311  0.343
2018 Gardill BR, Rivera-Acevedo RE, Tung CC, Okon M, McIntosh LP, Van Petegem F. The voltage-gated sodium channel EF-hands form an interaction with the III-IV linker that is disturbed by disease-causing mutations. Scientific Reports. 8: 4483. PMID 29540853 DOI: 10.1038/S41598-018-22713-Y  0.311
2018 Campiglio M, Costé de Bagneaux P, Ortner NJ, Tuluc P, Van Petegem F, Flucher BE. STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29363593 DOI: 10.1016/J.Bpj.2017.11.3446  0.453
2017 Wong King Yuen SM, Campiglio M, Tung CC, Flucher BE, Van Petegem F. Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078335 DOI: 10.1073/Pnas.1708852114  0.421
2017 Liu Y, Wei J, Wong King Yuen SM, Sun B, Tang Y, Wang R, Van Petegem F, Chen SRW. CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca2+ release termination and diminishes protein expression. Plos One. 12: e0184177. PMID 28961276 DOI: 10.1371/journal.pone.0184177  0.358
2016 Søndergaard MT, Liu Y, Larsen KT, Nani A, Tian X, Holt C, Wang R, Wimmer R, Van Petegem F, Fill M, Chen SR, Overgaard MT. The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+-binding but not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor. The Journal of Biological Chemistry. PMID 27927985 DOI: 10.1074/Jbc.M116.766253  0.537
2016 Van Petegem F. How to open a Ryanodine Receptor. Cell Research. PMID 27608934 DOI: 10.1038/cr.2016.106  0.326
2016 Ng LC, Putrenko I, Baronas V, Van Petegem F, Accili EA. Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure (London, England : 1993). PMID 27568927 DOI: 10.1016/j.str.2016.06.024  0.339
2016 Stevens CM, Rayani K, Genge CE, Singh G, Liang B, Roller JM, Li C, Li AY, Tieleman DP, van Petegem F, Tibbits GF. Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC. Biophysical Journal. 111: 38-49. PMID 27410732 DOI: 10.1016/j.bpj.2016.05.029  0.469
2016 Alzayady KJ, Wang L, Chandrasekhar R, Wagner LE, Van Petegem F, Yule DI. Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release. Science Signaling. 9: ra35. PMID 27048566 DOI: 10.1126/Scisignal.Aad6281  0.471
2015 Xiao Z, Guo W, Yuen SM, Wang R, Zhang L, Van Petegem F, Chen SR. The H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor. Plos One. 10: e0139058. PMID 26405799 DOI: 10.1371/journal.pone.0139058  0.436
2015 Yuchi Z, Yuen SM, Lau K, Underhill AQ, Cornea RL, Fessenden JD, Van Petegem F. Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant. Nature Communications. 6: 7947. PMID 26245150 DOI: 10.1038/ncomms8947  0.407
2015 Liu Y, Sun B, Xiao Z, Wang R, Guo W, Zhang JZ, Mi T, Wang Y, Jones PP, Van Petegem F, Chen SR. Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination. The Journal of Biological Chemistry. 290: 7736-46. PMID 25627681 DOI: 10.1074/jbc.M114.618827  0.499
2015 Van Petegem F. Ryanodine receptors: allosteric ion channel giants. Journal of Molecular Biology. 427: 31-53. PMID 25134758 DOI: 10.1016/j.jmb.2014.08.004  0.462
2014 Brath U, Lau K, Van Petegem F, Erdélyi M. Mapping the sevoflurane-binding sites of calmodulin. Pharmacology Research & Perspectives. 2: 5. PMID 25505574 DOI: 10.1002/Prp2.25  0.384
2014 Lau K, Van Petegem F. Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain. Nature Communications. 5: 5397. PMID 25370123 DOI: 10.1038/ncomms6397  0.457
2014 Lau K, Chan MM, Van Petegem F. Lobe-specific calmodulin binding to different ryanodine receptor isoforms. Biochemistry. 53: 932-46. PMID 24447242 DOI: 10.1021/bi401502x  0.531
2013 Amador FJ, Kimlicka L, Stathopulos PB, Gasmi-Seabrook GM, Maclennan DH, Van Petegem F, Ikura M. Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy. Journal of Molecular Biology. 425: 4034-46. PMID 23978697 DOI: 10.1016/J.Jmb.2013.08.015  0.413
2013 Kimlicka L, Tung CC, Carlsson AC, Lobo PA, Yuchi Z, Van Petegem F. The cardiac ryanodine receptor N-terminal region contains an anion binding site that is targeted by disease mutations. Structure (London, England : 1993). 21: 1440-9. PMID 23871484 DOI: 10.1016/J.Str.2013.06.012  0.346
2013 Liu Y, Kimlicka L, Hiess F, Tian X, Wang R, Zhang L, Jones PP, Van Petegem F, Chen SR. The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains. The Biochemical Journal. 454: 123-31. PMID 23746327 DOI: 10.1042/BJ20130594  0.468
2012 Van Petegem F, Lobo PA, Ahern CA. Seeing the forest through the trees: towards a unified view on physiological calcium regulation of voltage-gated sodium channels. Biophysical Journal. 103: 2243-51. PMID 23283222 DOI: 10.1016/J.Bpj.2012.10.020  0.582
2012 Van Petegem F. Ryanodine receptors: structure and function. The Journal of Biological Chemistry. 287: 31624-32. PMID 22822064 DOI: 10.1074/jbc.R112.349068  0.446
2012 Sarhan MF, Tung CC, Van Petegem F, Ahern CA. Crystallographic basis for calcium regulation of sodium channels. Proceedings of the National Academy of Sciences of the United States of America. 109: 3558-63. PMID 22331908 DOI: 10.1016/J.Bpj.2011.11.1783  0.593
2011 Kimlicka L, Van Petegem F. The structural biology of ryanodine receptors. Science China. Life Sciences. 54: 712-24. PMID 21786194 DOI: 10.1007/s11427-011-4198-2  0.33
2011 Yuchi Z, Van Petegem F. Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors. Channels (Austin, Tex.). 5: 120-3. PMID 21150295  0.38
2010 Tung CC, Lobo PA, Kimlicka L, Van Petegem F. The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature. 468: 585-8. PMID 21048710 DOI: 10.1038/nature09471  0.393
2010 Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. The Embo Journal. 29: 3924-38. PMID 20953164 DOI: 10.1038/Emboj.2010.260  0.633
2009 Lobo PA, Van Petegem F. Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations. Structure (London, England : 1993). 17: 1505-14. PMID 19913485 DOI: 10.1016/j.str.2009.08.016  0.343
2009 Sarhan MF, Van Petegem F, Ahern CA. A double tyrosine motif in the cardiac sodium channel domain III-IV linker couples calcium-dependent calmodulin binding to inactivation gating. The Journal of Biological Chemistry. 284: 33265-74. PMID 19808664 DOI: 10.1074/Jbc.M109.052910  0.433
2008 Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL. Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation. Structure (London, England : 1993). 16: 1455-67. PMID 18940602 DOI: 10.1016/J.Str.2008.07.010  0.636
2008 Van Petegem F, Duderstadt KE, Clark KA, Wang M, Minor DL. Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation. Structure (London, England : 1993). 16: 280-94. PMID 18275819 DOI: 10.1016/J.Str.2007.11.010  0.535
2006 Van Petegem F, Minor DL. The structural biology of voltage-gated calcium channel function and regulation. Biochemical Society Transactions. 34: 887-93. PMID 17052221 DOI: 10.1042/Bst0340887  0.533
2005 Van Petegem F, Chatelain FC, Minor DL. Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nature Structural & Molecular Biology. 12: 1108-15. PMID 16299511 DOI: 10.1038/Nsmb1027  0.656
2004 Van Petegem F, Clark KA, Chatelain FC, Minor DL. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature. 429: 671-5. PMID 15141227 DOI: 10.1038/Nature02588  0.646
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