Shelly Allen - Publications

University of Bristol, Bristol, England, United Kingdom 
Alzheimer's disease (pathophysiology, therapeutics), cholinergic systems

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Kailainathan S, Piers TM, Yi JH, Choi S, Fahey MS, Borger E, Gunn-Moore FJ, O'Neill L, Lever M, Whitcomb DJ, Cho K, Allen SJ. Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF). Pharmacological Research. PMID 26687096 DOI: 10.1016/j.phrs.2015.12.008  1
2015 Frias B, Santos J, Morgado M, Sousa MM, Gray SM, McCloskey KD, Allen S, Cruz F, Cruz CD. The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2146-60. PMID 25653370 DOI: 10.1523/JNEUROSCI.0373-14.2015  1
2015 Shoemark DK, Williams C, Fahey MS, Watson JJ, Tyler SJ, Scoltock SJ, Ellis RZ, Wickenden E, Burton AJ, Hemmings JL, Bailey CD, Dawbarn D, Jane DE, Willis CL, Sessions RB, ... Allen SJ, et al. Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery. Journal of Medicinal Chemistry. 58: 767-77. PMID 25454499 DOI: 10.1021/jm501307e  1
2015 Shoemark DK, Allen SJ. The microbiome and disease: reviewing the links between the oral microbiome, aging, and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 43: 725-38. PMID 25125469 DOI: 10.3233/JAD-141170  1
2014 Hicken EJ, Marmsater FP, Munson MC, Schlachter ST, Robinson JE, Allen S, Burgess LE, DeLisle RK, Rizzi JP, Topalov GT, Zhao Q, Hicks JM, Kallan NC, Tarlton E, Allen A, et al. Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability. Acs Medicinal Chemistry Letters. 5: 78-83. PMID 24900776 DOI: 10.1021/ml4003953  1
2013 Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL, Barbuti PA, Jo J, Tyler SJ, Allen SJ, Kunath T, Cho K, Caldwell MA. Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling. Stem Cell Research. 11: 1206-21. PMID 24013066 DOI: 10.1016/j.scr.2013.08.002  1
2013 Wang H, Sessions RB, Prime SS, Shoemark DK, Allen SJ, Hong W, Narayanan S, Paterson IC. Identification of novel small molecule TGF-β antagonists using structure-based drug design. Journal of Computer-Aided Molecular Design. 27: 365-72. PMID 23625024 DOI: 10.1007/s10822-013-9651-9  1
2013 Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK. GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacology & Therapeutics. 138: 155-75. PMID 23348013 DOI: 10.1016/j.pharmthera.2013.01.004  1
2013 Frias B, Allen S, Dawbarn D, Charrua A, Cruz F, Cruz CD. Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation. Neuroscience. 234: 88-102. PMID 23313710 DOI: 10.1016/j.neuroscience.2012.12.044  1
2012 Jackson LJ, Pheneger JA, Pheneger TJ, Davis G, Wright AD, Robinson JE, Allen S, Munson MC, Carter LL. The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease. Cellular Immunology. 272: 200-13. PMID 22078270 DOI: 10.1016/j.cellimm.2011.10.011  1
2012 Fathi AT, Arowojolu O, Swinnen I, Sato T, Rajkhowa T, Small D, Marmsater F, Robinson JE, Gross SD, Martinson M, Allen S, Kallan NC, Levis M. A potential therapeutic target for FLT3-ITD AML: PIM1 kinase. Leukemia Research. 36: 224-31. PMID 21802138 DOI: 10.1016/j.leukres.2011.07.011  1
2011 Allen SJ, Watson JJ, Dawbarn D. The neurotrophins and their role in Alzheimer's disease. Current Neuropharmacology. 9: 559-73. PMID 22654716 DOI: 10.2174/157015911798376190  1
2010 McNamee KE, Burleigh A, Gompels LL, Feldmann M, Allen SJ, Williams RO, Dawbarn D, Vincent TL, Inglis JJ. Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain. 149: 386-92. PMID 20350782 DOI: 10.1016/j.pain.2010.03.002  1
2010 Pinto R, Frias B, Allen S, Dawbarn D, McMahon SB, Cruz F, Cruz CD. Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. Neuroscience. 166: 907-16. PMID 20079809 DOI: 10.1016/j.neuroscience.2010.01.015  1
2009 Masoudi R, Ioannou MS, Coughlin MD, Pagadala P, Neet KE, Clewes O, Allen SJ, Dawbarn D, Fahnestock M. Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. The Journal of Biological Chemistry. 284: 18424-33. PMID 19389705 DOI: 10.1074/jbc.M109.007104  1
2008 Watson JJ, Allen SJ, Dawbarn D. Targeting nerve growth factor in pain: what is the therapeutic potential? Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 22: 349-59. PMID 18998753 DOI: 10.2165/0063030-200822060-00002  1
2008 Clewes O, Fahey MS, Tyler SJ, Watson JJ, Seok H, Catania C, Cho K, Dawbarn D, Allen SJ. Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin. Journal of Neurochemistry. 107: 1124-35. PMID 18808449 DOI: 10.1111/j.1471-4159.2008.05698.x  1
2007 Hatchett CS, Tyler S, Armstrong D, Dawbarn D, Allen SJ. Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro. Brain Research. 1147: 248-55. PMID 17349981 DOI: 10.1016/j.brainres.2007.02.002  1
2006 Nassenstein C, Dawbarn D, Pollock K, Allen SJ, Erpenbeck VJ, Spies E, Krug N, Braun A. Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. The Journal of Allergy and Clinical Immunology. 118: 597-605. PMID 16950277 DOI: 10.1016/j.jaci.2006.04.052  1
2006 Dawbarn D, Fahey M, Watson J, Tyler S, Shoemark D, Sessions R, Zhang R, Brady L, Willis C, Allen SJ. NGF receptor TrkAd5: therapeutic agent and drug design target. Biochemical Society Transactions. 34: 587-90. PMID 16856868 DOI: 10.1042/BST0340587  1
2006 Allen SJ, Dawbarn D. Clinical relevance of the neurotrophins and their receptors. Clinical Science (London, England : 1979). 110: 175-91. PMID 16411894 DOI: 10.1042/CS20050161  1
2006 Watson JJ, Fahey MS, van den Worm E, Engels F, Nijkamp FP, Stroemer P, McMahon S, Allen SJ, Dawbarn D. TrkAd5: A novel therapeutic agent for treatment of inflammatory pain and asthma. The Journal of Pharmacology and Experimental Therapeutics. 316: 1122-9. PMID 16284276 DOI: 10.1124/jpet.105.095844  1
2006 Love S, Siew LK, Dawbarn D, Wilcock GK, Ben-Shlomo Y, Allen SJ. Premorbid effects of APOE on synaptic proteins in human temporal neocortex. Neurobiology of Aging. 27: 797-803. PMID 15979210 DOI: 10.1016/j.neurobiolaging.2005.04.008  1
2006 Hansen JD, Newhouse BJ, Allen S, Anderson A, Eary T, Schiro J, Gaudino J, Laird E, Allen AC, Chantry D, Eberhardt C, Burgess LE. Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists Tetrahedron Letters. 47: 69-72. DOI: 10.1016/j.tetlet.2005.10.139  1
2005 Hu VY, Zvara P, Dattilio A, Redman TL, Allen SJ, Dawbarn D, Stroemer RP, Vizzard MA. Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis. The Journal of Urology. 173: 1016-21. PMID 15711368 DOI: 10.1097/01.ju.0000155170.15023.e5  1
2004 Siew LK, Love S, Dawbarn D, Wilcock GK, Allen SJ. Measurement of pre- and post-synaptic proteins in cerebral cortex: effects of post-mortem delay. Journal of Neuroscience Methods. 139: 153-9. PMID 15488227 DOI: 10.1016/j.jneumeth.2004.04.020  1
2004 Newhouse B, Allen S, Fauber B, Anderson AS, Eary CT, Hansen JD, Schiro J, Gaudino JJ, Laird E, Chantry D, Eberhardt C, Burgess LE. Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists. Bioorganic & Medicinal Chemistry Letters. 14: 5537-42. PMID 15482919 DOI: 10.1016/j.bmcl.2004.09.001  1
2004 Allen S, Newhouse B, Anderson AS, Fauber B, Allen A, Chantry D, Eberhardt C, Odingo J, Burgess LE. Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists. Bioorganic & Medicinal Chemistry Letters. 14: 1619-24. PMID 15026036 DOI: 10.1016/j.bmcl.2004.01.072  1
2003 Dawbarn D, Allen SJ. Neurotrophins and neurodegeneration. Neuropathology and Applied Neurobiology. 29: 211-30. PMID 12787319 DOI: 10.1046/j.1365-2990.2003.00487.x  1
2002 Tyler SJ, Dawbarn D, Wilcock GK, Allen SJ. alpha- and beta-secretase: profound changes in Alzheimer's disease. Biochemical and Biophysical Research Communications. 299: 373-6. PMID 12445809 DOI: 10.1016/S0006-291X(02)02635-9  1
2002 Naylor RL, Robertson AG, Allen SJ, Sessions RB, Clarke AR, Mason GG, Burston JJ, Tyler SJ, Wilcock GK, Dawbarn D. A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4. Biochemical and Biophysical Research Communications. 291: 501-7. PMID 11855816 DOI: 10.1006/bbrc.2002.6468  1
2001 Banfield MJ, Naylor RL, Robertson AG, Allen SJ, Dawbarn D, Brady RL. Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure (London, England : 1993). 9: 1191-9. PMID 11738045 DOI: 10.1016/S0969-2126(01)00681-5  1
2001 Robertson AG, Banfield MJ, Allen SJ, Dando JA, Mason GG, Tyler SJ, Bennett GS, Brain SD, Clarke AR, Naylor RL, Wilcock GK, Brady RL, Dawbarn D. Identification and structure of the nerve growth factor binding site on TrkA. Biochemical and Biophysical Research Communications. 282: 131-41. PMID 11263982 DOI: 10.1006/bbrc.2001.4462  1
2001 Allen SJ, Robertson AG, Tyler SJ, Wilcock GK, Dawbarn D. Recombinant human nerve growth factor for clinical trials: protein expression, purification, stability and characterisation of binding to infusion pumps. Journal of Biochemical and Biophysical Methods. 47: 239-55. PMID 11245895 DOI: 10.1016/S0165-022X(01)00134-8  1
2001 Fahey MS, Dawbarn D, Allen SJ, Paterson IC, Prime SS. Expression of recombinant extracellular domain of the type II transforming growth factor-beta receptor: utilization in a modified enzyme-linked immunoabsorbent assay to screen TGF-beta agonists and antagonists. Analytical Biochemistry. 290: 272-6. PMID 11237329 DOI: 10.1006/abio.2000.4948  1
2000 O'Meara G, Coumis U, Ma SY, Kehr J, Mahoney S, Bacon A, Allen SJ, Holmes F, Kahl U, Wang FH, Kearns IR, Ove-Ogren S, Dawbarn D, Mufson EJ, Davies C, et al. Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proceedings of the National Academy of Sciences of the United States of America. 97: 11569-74. PMID 11016971 DOI: 10.1073/pnas.210254597  1
2000 Smith SK, Anderson HA, Yu G, Robertson AG, Allen SJ, Tyler SJ, Naylor RL, Mason G, Wilcock GW, Roche PA, Fraser PE, Dawbarn D. Identification of syntaxin 1A as a novel binding protein for presenilin-1. Brain Research. Molecular Brain Research. 78: 100-7. PMID 10891589 DOI: 10.1016/S0169-328X(00)00079-6  1
1999 Allen SJ, Wilcock GK, Dawbarn D. Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease. Biochemical and Biophysical Research Communications. 264: 648-51. PMID 10543986 DOI: 10.1006/bbrc.1999.1561  1
1997 Allen SJ, MacGowan SH, Tyler S, Wilcock GK, Robertson AG, Holden PH, Smith SK, Dawbarn D. Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype. Neuroscience Letters. 239: 33-6. PMID 9547165 DOI: 10.1016/S0304-3940(97)00872-0  1
1997 Holden PH, Asopa V, Robertson AG, Clarke AR, Tyler S, Bennett GS, Brain SD, Wilcock GK, Allen SJ, Smith SK, Dawbarn D. Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor. Nature Biotechnology. 15: 668-72. PMID 9219271 DOI: 10.1038/nbt0797-668  1
1994 Allen SJ, Dawbarn D, Eckford SD, Wilcock GK, Ashcroft M, Colebrook SM, Feeney R, MacGowan SH. Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. Neuroscience. 60: 825-34. PMID 7936202 DOI: 10.1016/0306-4522(94)90507-X  1
1991 Allen SJ, MacGowan SH, Treanor JJ, Feeney R, Wilcock GK, Dawbarn D. Normal beta-NGF content in Alzheimer's disease cerebral cortex and hippocampus. Neuroscience Letters. 131: 135-9. PMID 1791973  1
1991 Treanor JJ, Dawbarn D, Allen SJ, MacGowan SH, Wilcock GK. Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain. Neuroscience Letters. 121: 73-6. PMID 1708488 DOI: 10.1016/0304-3940(91)90652-A  1
1991 Allen SJ, MacGowan SH, Treanor JJS, Feeney R, Wilcock GK, Dawbarn D. Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus Neuroscience Letters. 131: 135-139. DOI: 10.1016/0304-3940(91)90354-V  1
1990 Allen SJ, Dawbarn D, Macgowan SH, Wikock GK, Treanor JJS, Moss TH. Quantitative morphometric analysis of basal forebrain neurons expressing β-nerve growth factor receptors in normal and alzheimer’s disease brains Dementia and Geriatric Cognitive Disorders. 1: 125-137. DOI: 10.1159/000107132  1
1989 Allen SJ, Dawbarn D, Spillantini MG, Goedert M, Wilcock GK, Moss TH, Semenenko FM. Distribution of beta-nerve growth factor receptors in the human basal forebrain. The Journal of Comparative Neurology. 289: 626-40. PMID 2556457 DOI: 10.1002/cne.902890408  1
1988 Allen SJ, Dawbarn D, Wilcock GK. Morphometric immunochemical analysis of neurons in the nucleus basalis of Meynert in Alzheimer's disease. Brain Research. 454: 275-81. PMID 3409011 DOI: 10.1016/0006-8993(88)90827-X  1
1988 Dawbarn D, Allen SJ, Semenenko FM. Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain. Neuroscience Letters. 94: 138-44. PMID 2853851 DOI: 10.1016/0304-3940(88)90284-4  1
1988 Dawbarn D, Allen SJ, Semenenko FM. Immunohistochemical localization of beta-nerve growth factor receptors in the forebrain of the rat. Brain Research. 440: 185-9. PMID 2833990 DOI: 10.1016/0006-8993(88)91175-4  1
1983 Sims NR, Bowen DM, Allen SJ, Smith CC, Neary D, Thomas DJ, Davison AN. Presynaptic cholinergic dysfunction in patients with dementia Journal of Neurochemistry. 40: 503-509. PMID 6822833 DOI: 10.1111/j.1471-4159.1983.tb11311.x  1
1983 Bowen DM, Allen SJ, Benton JS, Goodhardt MJ, Haan EA, Palmer AM, Sims NR, Smith CC, Spillane JA, Esiri MM, Neary D, Snowdon JS, Wilcock GK, Davison AN. Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease. Journal of Neurochemistry. 41: 266-72. PMID 6306169  1
1983 Allen SJ, Benton JS, Goodhardt MJ, Haan EA, Sims NR, Smith CC, Spillane JA, Bowen DM, Davison AN. Biochemical evidence of selective nerve cell changes in the normal ageing human and rat brain Journal of Neurochemistry. 41: 256-265. PMID 6134787  1
1982 Bowen DM, Benton JS, Spillane JA, Smith CCT, Allen SJ. Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients Journal of the Neurological Sciences. 57: 191-202. PMID 7161618 DOI: 10.1016/0022-510X(82)90026-0  1
1982 Benton JS, Bowen DM, Allen SJ, Haan EA, Davison AN, Neary D, Murphy RP, Snowden JS. Alzheimer's disease as a disorder of isodendritic core Lancet. 1: 456. PMID 6121126  1
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