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James C. Burnett, Ph.D. - Publications

Affiliations: 
2000 Virginia Commonwealth University, Richmond, VA, United States 
Area:
Pharmaceutical Chemistry
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Kiris E, Burnett JC, Kane CD, Bavari S. Recent advances in botulinum neurotoxin inhibitor development. Current Topics in Medicinal Chemistry. 14: 2044-61. PMID 25335887 DOI: 10.2174/1568026614666141022093350  0.338
2014 Videnović M, Opsenica DM, Burnett JC, Gomba L, Nuss JE, Selaković Z, Konstantinović J, Krstić M, Segan S, Zlatović M, Sciotti RJ, Bavari S, Solaja BA. Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria. Journal of Medicinal Chemistry. 57: 4134-53. PMID 24742203 DOI: 10.1021/Jm500033R  0.37
2013 Opsenica IM, Tot M, Gomba L, Nuss JE, Sciotti RJ, Bavari S, Burnett JC, Solaja BA. 4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity. Journal of Medicinal Chemistry. 56: 5860-71. PMID 23815186 DOI: 10.1021/Jm4006077  0.382
2013 dos Santos Edos A, Hamel E, Bai R, Burnett JC, Tozatti CS, Bogo D, Perdomo RT, Antunes AM, Marques MM, Matos Mde F, de Lima DP. Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity. Bioorganic & Medicinal Chemistry Letters. 23: 4669-73. PMID 23810282 DOI: 10.1016/J.Bmcl.2013.06.009  0.301
2013 Šegan S, Trifković J, Verbić T, Opsenica D, Zlatović M, Burnett J, Šolaja B, Milojković-Opsenica D. Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives. Journal of Pharmaceutical and Biomedical Analysis. 72: 231-239. PMID 22985530 DOI: 10.1016/J.Jpba.2012.08.025  0.347
2013 Tot M, Opsenica DM, Mitrić M, Burnett JC, Gomba L, Bavari S, Šolaja BA. New 9-aminoacridine derivatives as inhibitors of botulinum neurotoxins and P. falciparum malaria Journal of the Serbian Chemical Society. 78: 1847-1864. DOI: 10.2298/Jsc130924112T  0.341
2012 Selaković Z, Opsenica D, Eaton B, Retterer C, Bavari S, Burnett JC, Solaja BA, Panchal RG. A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor. Viruses. 4: 1279-88. PMID 23012625 DOI: 10.3390/V4081279  0.371
2012 Opsenica I, Filipovic V, Nuss JE, Gomba LM, Opsenica D, Burnett JC, Gussio R, Solaja BA, Bavari S. The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease. European Journal of Medicinal Chemistry. 53: 374-9. PMID 22516424 DOI: 10.1016/J.Ejmech.2012.03.043  0.316
2011 Ruthel G, Burnett JC, Nuss JE, Wanner LM, Tressler LE, Torres-Melendez E, Sandwick SJ, Retterer CJ, Bavari S. Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors. Toxins. 3: 207-17. PMID 22069707 DOI: 10.3390/Toxins3030207  0.309
2011 Bai R, Nguyen TL, Burnett JC, Atasoylu O, Munro MH, Pettit GR, Smith AB, Gussio R, Hamel E. Interactions of halichondrin B and eribulin with tubulin. Journal of Chemical Information and Modeling. 51: 1393-404. PMID 21539396 DOI: 10.1021/Ci200077T  0.361
2011 Opsenica I, Burnett JC, Gussio R, Opsenica D, Todorović N, Lanteri CA, Sciotti RJ, Gettayacamin M, Basilico N, Taramelli D, Nuss JE, Wanner L, Panchal RG, Solaja BA, Bavari S. A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus. Journal of Medicinal Chemistry. 54: 1157-69. PMID 21265542 DOI: 10.1021/Jm100938U  0.381
2011 Li B, Peet NP, Butler MM, Burnett JC, Moir DT, Bowlin TL. Small molecule inhibitors as countermeasures for botulinum neurotoxin intoxication. Molecules (Basel, Switzerland). 16: 202-20. PMID 21193845 DOI: 10.3390/Molecules16010202  0.342
2010 Nuss JE, Dong Y, Wanner LM, Ruthel G, Wipf P, Gussio R, Vennerstrom JL, Bavari S, Burnett JC. Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease. Acs Medicinal Chemistry Letters. 1: 301-305. PMID 21116458 DOI: 10.1021/Ml100056V  0.327
2010 Zuniga JE, Hammill JT, Drory O, Nuss JE, Burnett JC, Gussio R, Wipf P, Bavari S, Brunger AT. Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A. Plos One. 5: e11378. PMID 20614028 DOI: 10.1371/Journal.Pone.0011378  0.391
2009 Burnett JC, Wang C, Nuss JE, Nguyen TL, Hermone AR, Schmidt JJ, Gussio R, Wipf P, Bavari S. Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease. Bioorganic & Medicinal Chemistry Letters. 19: 5811-3. PMID 19703771 DOI: 10.1016/J.Bmcl.2009.01.111  0.342
2009 Wang C, Widom J, Petronijevic F, Burnett JC, Nuss JE, Bavari S, Gussio R, Wipf P. Synthesis and biological evaluation of inhibitors of botulinum neurotoxin metalloprotease Heterocycles. 79: 487-520. DOI: 10.3987/Com-08-S(D)8  0.356
2008 Hermone AR, Burnett JC, Nuss JE, Tressler LE, Nguyen TL, Solaja BA, Vennerstrom JL, Schmidt JJ, Wipf P, Bavari S, Gussio R. Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore. Chemmedchem. 3: 1905-12. PMID 19006141 DOI: 10.1002/Cmdc.200800241  0.393
2008 Zuniga JE, Schmidt JJ, Fenn T, Burnett JC, Araç D, Gussio R, Stafford RG, Badie SS, Bavari S, Brunger AT. A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate. Structure (London, England : 1993). 16: 1588-97. PMID 18940613 DOI: 10.1016/J.Str.2008.07.011  0.391
2008 Solaja BA, Opsenica D, Smith KS, Milhous WK, Terzić N, Opsenica I, Burnett JC, Nuss J, Gussio R, Bavari S. Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A. Journal of Medicinal Chemistry. 51: 4388-91. PMID 18637666 DOI: 10.1021/Jm800737Y  0.351
2007 Burnett JC, Opsenica D, Sriraghavan K, Panchal RG, Ruthel G, Hermone AR, Nguyen TL, Kenny TA, Lane DJ, McGrath CF, Schmidt JJ, Vennerstrom JL, Gussio R, Solaja BA, Bavari S. A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease. Journal of Medicinal Chemistry. 50: 2127-36. PMID 17417831 DOI: 10.1021/Jm061446E  0.411
2007 Burnett JC, Ruthel G, Stegmann CM, Panchal RG, Nguyen TL, Hermone AR, Stafford RG, Lane DJ, Kenny TA, McGrath CF, Wipf P, Stahl AM, Schmidt JJ, Gussio R, Brunger AT, et al. Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons. The Journal of Biological Chemistry. 282: 5004-14. PMID 17092934 DOI: 10.1074/Jbc.M608166200  0.397
2007 Nguyen TL, Panchal RG, Topol IA, Lane D, Kenny T, Burnett JC, Hermone AR, McGrath C, Burt SK, Gussio R, Bavari S. A theoretical study of anthrax lethal factor inhibition by a set of novel carbamimidolyl-aryl-vinyl-carboxamidines: A possible mechanism involving zinc-ligation by amidine Journal of Molecular Structure: Theochem. 821: 139-144. DOI: 10.1016/J.Theochem.2007.07.009  0.365
2006 Dabydeen DA, Burnett JC, Bai R, Verdier-Pinard P, Hickford SJ, Pettit GR, Blunt JW, Munro MH, Gussio R, Hamel E. Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Molecular Pharmacology. 70: 1866-75. PMID 16940412 DOI: 10.1124/Mol.106.026641  0.388
2005 Nguyen TL, McGrath C, Hermone AR, Burnett JC, Zaharevitz DW, Day BW, Wipf P, Hamel E, Gussio R. A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. Journal of Medicinal Chemistry. 48: 6107-16. PMID 16162011 DOI: 10.1021/Jm050502T  0.381
2005 Burnett JC, Schmidt JJ, McGrath CF, Nguyen TL, Hermone AR, Panchal RG, Vennerstrom JL, Kodukula K, Zaharevitz DW, Gussio R, Bavari S. Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding. Bioorganic & Medicinal Chemistry. 13: 333-41. PMID 15598556 DOI: 10.1016/J.Bmc.2004.10.026  0.414
2004 Safo MK, Abdulmalik O, Danso-Danquah R, Burnett JC, Nokuri S, Joshi GS, Musayev FN, Asakura T, Abraham DJ. Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds. Journal of Medicinal Chemistry. 47: 4665-76. PMID 15341482 DOI: 10.1021/Jm0498001  0.541
2004 Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, et al. Identification of small molecule inhibitors of anthrax lethal factor Nature Structural and Molecular Biology. 11: 67-72. PMID 14718925 DOI: 10.1038/Nsmb711  0.369
2003 Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S. Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity. Biochemical and Biophysical Research Communications. 310: 84-93. PMID 14511652 DOI: 10.1016/J.Bbrc.2003.08.112  0.403
2003 Joshi GS, Burnett JC, Abraham DJ. Cardiac Drugs: Antianginal, Vasodilators, and Antiarrhythmics Burger's Medicinal Chemistry and Drug Discovery. DOI: 10.1002/0471266949.Bmc041  0.479
2002 Safo MK, Burnett JC, Musayev FN, Nokuri S, Abraham DJ. Structure of human carbonmonoxyhemoglobin at 2.16 A: a snapshot of the allosteric transition. Acta Crystallographica. Section D, Biological Crystallography. 58: 2031-7. PMID 12454461 DOI: 10.1107/S0907444902015809  0.497
2002 Safo MK, Boyiri T, Burnett JC, Danso-Danquah R, Moure CM, Joshi GS, Abraham DJ. X-ray crystallographic analyses of symmetrical allosteric effectors of hemoglobin: compounds designed to link primary and secondary binding sites. Acta Crystallographica. Section D, Biological Crystallography. 58: 634-44. PMID 11914488 DOI: 10.1107/S0907444902002627  0.55
2001 Kellogg GE, Burnett JC, Abraham DJ. Very empirical treatment of solvation and entropy: a force field derived from log Po/w. Journal of Computer-Aided Molecular Design. 15: 381-93. PMID 11349819 DOI: 10.1023/A:1011136228678  0.526
2001 Safo MK, Moure CM, Burnett JC, Joshi GS, Abraham DJ. High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector. Protein Science : a Publication of the Protein Society. 10: 951-7. PMID 11316875 DOI: 10.1110/Ps.50601  0.559
2001 Burnett JC, Botti P, Abraham DJ, Kellogg GE. Computationally accessible method for estimating free energy changes resulting from site-specific mutations of biomolecules: systematic model building and structural/hydropathic analysis of deoxy and oxy hemoglobins. Proteins. 42: 355-77. PMID 11151007 DOI: 10.1002/1097-0134(20010215)42:3<355::Aid-Prot60>3.0.Co;2-F  0.523
2000 Burnett JC, Kellogg GE, Abraham DJ. Computational methodology for estimating changes in free energies of biomolecular association upon mutation. The importance of bound water in dimer-tetramer assembly for beta 37 mutant hemoglobins. Biochemistry. 39: 1622-33. PMID 10677211 DOI: 10.1021/Bi991724U  0.51
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