William E. Sonntag - Publications

Affiliations: 
University of Oklahoma, Norman, OK, United States 
Area:
brain aging

197 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Miller LR, Tarantini S, Nyúl-Tóth Á, Johnston MP, Martin T, Bullen EC, Bickel MA, Sonntag WE, Yabluchanskiy A, Csiszar A, Ungvari ZI, Elliott MH, Conley SM. Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging. Frontiers in Aging Neuroscience. 14: 788296. PMID 35356301 DOI: 10.3389/fnagi.2022.788296  0.348
2021 Tarantini S, Nyúl-Tóth Á, Yabluchanskiy A, Csipo T, Mukli P, Balasubramanian P, Ungvari A, Toth P, Benyo Z, Sonntag WE, Ungvari Z, Csiszar A. Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype. Geroscience. PMID 34383203 DOI: 10.1007/s11357-021-00405-2  0.351
2021 Tarantini S, Balasubramanian P, Yabluchanskiy A, Ashpole NM, Logan S, Kiss T, Ungvari A, Nyúl-Tóth Á, Schwartzman ML, Benyo Z, Sonntag WE, Csiszar A, Ungvari Z. IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging. Geroscience. PMID 33674953 DOI: 10.1007/s11357-021-00350-0  0.366
2020 Parks EE, Logan S, Yeganeh A, Farley JA, Owen DB, Sonntag WE. Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. Journal of Lipid Research. PMID 32669383 DOI: 10.1194/Jlr.Ra119000479  0.403
2020 Yabluchanskiy A, Tarantini S, Balasubramanian P, Kiss T, Csipo T, Fülöp GA, Lipecz A, Ahire C, DelFavero J, Nyul-Toth A, Sonntag WE, Schwartzman ML, Campisi J, Csiszar A, Ungvari Z. Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice. Geroscience. PMID 31960269 DOI: 10.1007/s11357-020-00154-8  0.351
2019 Farias Quipildor GE, Mao K, Hu Z, Novaj A, Cui MH, Gulinello M, Branch CA, Gubbi S, Patel K, Moellering DR, Tarantini S, Kiss T, Yabluchanskiy A, Ungvari Z, Sonntag WE, et al. Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice. Geroscience. PMID 31076997 DOI: 10.1007/s11357-019-00065-3  0.374
2018 Reagan AM, Gu X, Paudel S, Ashpole NM, Zalles M, Sonntag WE, Ungvari Z, Csiszar A, Otalora L, Freeman WM, Stout MB, Elliott MH. Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency. Neurobiology of Aging. 71: 1-12. PMID 30059797 DOI: 10.1016/J.Neurobiolaging.2018.06.039  0.426
2018 Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, et al. Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 73: 853-863. PMID 29905772 DOI: 10.1093/Gerona/Glx177  0.35
2018 Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Fulop GA, Hertelendy P, Gautam T, Farkas E, Perz A, Rabinovitch PS, Sonntag WE, Csiszar A, Ungvari Z. Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice. Aging Cell. PMID 29405550 DOI: 10.1111/Acel.12731  0.389
2018 Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, ... ... Sonntag WE, et al. Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Molecular Metabolism. PMID 29398615 DOI: 10.1016/J.Molmet.2018.01.013  0.462
2018 Koller A, Toth P, Csiszar A, Sonntag WE, Ungvari Z. Hypertension And Ageing Lead To Impairment Of Myogenic Vasomotor Mechanism, Hippocampal Expression Of Genes Involved In Beta-Amyloid Generation And Cognitive Dysfunction Journal of Hypertension. 36. DOI: 10.1097/01.Hjh.0000539221.80651.8C  0.326
2017 Mangold CA, Wronowski B, Du M, Masser DR, Hadad N, Bixler GV, Brucklacher RM, Ford MM, Sonntag WE, Freeman WM. Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging. Journal of Neuroinflammation. 14: 141. PMID 28732515 DOI: 10.1186/S12974-017-0920-8  0.337
2017 Ashpole NM, Logan S, Yabluchanskiy A, Mitschelen MC, Yan H, Farley JA, Hodges EL, Ungvari Z, Csiszar A, Chen S, Georgescu C, Hubbard GB, Ikeno Y, Sonntag WE. IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. Geroscience. PMID 28409331 DOI: 10.1007/s11357-017-9971-0  0.401
2017 Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Springo Z, Fulop GA, Ashpole N, Gautam T, Giles CB, Wren JD, Sonntag WE, Csiszar A, Ungvari Z. Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell. PMID 28295976 DOI: 10.1111/Acel.12583  0.449
2017 Hopiavuori BR, Agbaga MP, Brush RS, Sullivan MT, Sonntag WE, Anderson RE. Regional Changes in CNS and Retinal Glycerophospholipid Profiles with Age - A Molecular Blueprint. Journal of Lipid Research. PMID 28202633 DOI: 10.1194/Jlr.M070714  0.352
2017 Valcarcel-Ares MN, Tucsek Z, Tarantini S, Hertelendy P, Giles CB, Gautam T, Orock A, Sonntag WE, Wren JD, Csiszar A, Deak F, Ungvari Z. Hypertension-induced impairment in synaptic plasticity and dysregulation of genes involved in synaptic function in the mouse hippocampus: Implications for the pathogenesis of vascular cognitive impairment in aging Experimental Gerontology. 94: 119. DOI: 10.1016/J.Exger.2017.02.044  0.33
2017 Orock A, Logan S, Szarka N, Csiszar A, Sonntag W, Deak F. Cognitive impairment in the aging brain: Effects of IGF-1 treatment on synaptic transmission Experimental Gerontology. 94: 119. DOI: 10.1016/J.Exger.2017.02.043  0.393
2017 Logan S, Ashpole N, Farley J, Owens D, Sonntag WE. Reduced igf-1 signaling alters sirtuins in hippocampus and affects learning and memory Experimental Gerontology. 94: 108. DOI: 10.1016/J.Exger.2017.02.012  0.308
2017 Ashpole NM, Logan S, Parks EE, Hodges EL, Owen DB, Farley JA, Sonntag WE. Comparing the effects of growth hormone and IGF-1 signaling on spatial learning and memory Experimental Gerontology. 94: 108. DOI: 10.1016/J.Exger.2017.02.011  0.363
2016 Sonntag WE, Ungvari Z. GeroScience: understanding the interaction of processes of aging and chronic diseases. Age (Dordrecht, Netherlands). PMID 27924421 DOI: 10.1007/S11357-016-9953-7  0.312
2016 Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, Sonntag WE, Ungvari Z, Csiszar A. Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordrecht, Netherlands). PMID 27613724 DOI: 10.1007/S11357-016-9931-0  0.448
2016 Tarantini S, Giles CB, Wren JD, Ashpole NM, Valcarcel-Ares MN, Wei JY, Sonntag WE, Ungvari Z, Csiszar A. IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age (Dordrecht, Netherlands). PMID 27566308 DOI: 10.1007/S11357-016-9943-9  0.409
2016 Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics & Chromatin. 9: 30. PMID 27413395 DOI: 10.1186/S13072-016-0080-6  0.38
2016 Luo TD, Alton TB, Apel PJ, Cai J, Barnwell JC, Sonntag WE, Smith TL, Li Z. Effects of age, IGF-1 on rat neurotrophin receptor expression after nerve injury. Muscle & Nerve. PMID 26970089 DOI: 10.1002/Mus.25106  0.429
2016 Ashpole NM, Herron JC, Estep PN, Logan S, Hodges EL, Yabluchanskiy A, Humphrey MB, Sonntag WE. Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice. Age (Dordrecht, Netherlands). 38: 38. PMID 26968399 DOI: 10.1007/S11357-016-9902-5  0.389
2016 Mangold CA, Masser DR, Stanford DR, Bixler GV, Pisupati A, Giles CB, Wren JD, Ford MM, Sonntag WE, Freeman WM. CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26786204 DOI: 10.1093/Gerona/Glv232  0.412
2015 Deak F, Freeman WM, Ungvari Z, Csiszar A, Sonntag WE. Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26590911 DOI: 10.1093/Gerona/Glv206  0.419
2015 Ashpole NM, Herron JC, Mitschelen MC, Farley JA, Logan S, Yan H, Ungvari Z, Hodges EL, Csiszar A, Ikeno Y, Humphrey MB, Sonntag WE. IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26260312 DOI: 10.1002/Jbmr.2689  0.395
2015 Tarantini S, Hertelendy P, Tucsek Z, Valcarcel-Ares MN, Smith N, Menyhart A, Farkas E, Hodges EL, Towner R, Deak F, Sonntag WE, Csiszar A, Ungvari Z, Toth P. Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26174328 DOI: 10.1038/Jcbfm.2015.162  0.377
2015 Toth P, Tarantini S, Ashpole NM, Tucsek Z, Milne GL, Valcarcel-Ares NM, Menyhart A, Farkas E, Sonntag WE, Csiszar A, Ungvari Z. IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging. Aging Cell. PMID 26172407 DOI: 10.1111/Acel.12372  0.478
2015 Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB, Wren JD, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell. 14: 400-8. PMID 25677910 DOI: 10.1111/Acel.12315  0.387
2015 Springo Z, Tarantini S, Toth P, Tucsek Z, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 25631392 DOI: 10.1093/Gerona/Glu244  0.34
2015 Springo Z, Toth P, Tarantini S, Ashpole NM, Tucsek Z, Sonntag WE, Csiszar A, Koller A, Ungvari ZI. Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 527-30. PMID 25605292 DOI: 10.1038/Jcbfm.2014.256  0.322
2015 Ashpole NM, Sanders JE, Hodges EL, Yan H, Sonntag WE. Growth hormone, insulin-like growth factor-1 and the aging brain. Experimental Gerontology. 68: 76-81. PMID 25300732 DOI: 10.1016/J.Exger.2014.10.002  0.509
2015 Banki E, Sosnowska D, Tucsek Z, Gautam T, Toth P, Tarantini S, Tamas A, Helyes Z, Reglodi D, Sonntag WE, Csiszar A, Ungvari Z. Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 70: 665-74. PMID 25136000 DOI: 10.1093/Gerona/Glu116  0.444
2015 Csiszár A, Csiszar A, Pinto JT, Gautam T, Kleusch C, Hoffmann B, Tucsek Z, Toth P, Sonntag WE, Ungvari Z. Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 70: 303-13. PMID 24642904 DOI: 10.1093/Gerona/Glu029  0.34
2014 Ungvari Z, Sonntag WE. Brain and cerebrovascular aging--new mechanisms and insights. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1307-10. PMID 25301834 DOI: 10.1093/Gerona/Glu187  0.358
2014 Toth P, Tucsek Z, Tarantini S, Sosnowska D, Gautam T, Mitschelen M, Koller A, Sonntag WE, Csiszar A, Ungvari Z. IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1887-97. PMID 25248835 DOI: 10.1038/Jcbfm.2014.156  0.415
2014 Yan H, Mitschelen M, Toth P, Ashpole NM, Farley JA, Hodges EL, Warrington JP, Han S, Fung KM, Csiszar A, Ungvari Z, Sonntag WE. Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1353-62. PMID 25098324 DOI: 10.1093/Gerona/Glu118  0.5
2014 Masser DR, Bixler GV, Brucklacher RM, Yan H, Giles CB, Wren JD, Sonntag WE, Freeman WM. Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1311-24. PMID 24994846 DOI: 10.1093/Gerona/Glu091  0.409
2014 Csiszar A, Gautam T, Sosnowska D, Tarantini S, Banki E, Tucsek Z, Toth P, Losonczy G, Koller A, Reglodi D, Giles CB, Wren JD, Sonntag WE, Ungvari Z. Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats. American Journal of Physiology. Heart and Circulatory Physiology. 307: H292-306. PMID 24906921 DOI: 10.1152/Ajpheart.00307.2014  0.387
2014 Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1339-52. PMID 24895269 DOI: 10.1093/Gerona/Glu080  0.368
2014 Sosnowska D, Richardson C, Sonntag WE, Csiszar A, Ungvari Z, Ridgway I. A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1448-61. PMID 24347613 DOI: 10.1093/Gerona/Glt201  0.384
2014 Toth P, Tarantini S, Tucsek Z, Ashpole NM, Sosnowska D, Gautam T, Ballabh P, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase. American Journal of Physiology. Heart and Circulatory Physiology. 306: H299-308. PMID 24322615 DOI: 10.1152/Ajpheart.00744.2013  0.406
2014 Tucsek Z, Toth P, Sosnowska D, Gautam T, Mitschelen M, Koller A, Szalai G, Sonntag WE, Ungvari Z, Csiszar A. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1212-26. PMID 24269929 DOI: 10.1093/Gerona/Glt177  0.366
2014 Springo Z, Toth P, Tarantini S, Tucsek Z, Sonntag W, Csiszar A, Ungvari Z, Koller A. P693Pulsatile pressure-induced myogenic response of mouse cerebral arteries is impaired by aging Cardiovascular Research. 103: S126.5-S126. DOI: 10.1093/Cvr/Cvu098.116  0.375
2014 Springo Z, Toth P, Tarantini S, Tucsek Z, Sonntag W, Csiszar A, Ungvari Z, Koller A. P451Pulsatile pressure-induced myogenic response is impaired by aging in mouse cerebral arteries Cardiovascular Research. 103: S83.1-S83. DOI: 10.1093/Cvr/Cvu091.129  0.372
2014 Deak F, Logan S, Orock A, Mitschelen MC, Sonntag WE. P3-045: COGNITIVE DECLINE AND AGE-RELATED CHANGES IN NEUROTRANSMISSION IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P644-P645. DOI: 10.1016/J.Jalz.2014.05.1132  0.334
2013 Warrington JP, Ashpole N, Csiszar A, Lee YW, Ungvari Z, Sonntag WE. Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications. Journal of Vascular Research. 50: 445-57. PMID 24107797 DOI: 10.1159/000354227  0.316
2013 Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Schwartzman ML, Sonntag WE, Ungvari Z. Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. American Journal of Physiology. Heart and Circulatory Physiology. 305: H1698-708. PMID 24097425 DOI: 10.1152/Ajpheart.00377.2013  0.335
2013 Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, Deak F, Sonntag WE, Ungvari Z. Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease. American Journal of Physiology. Heart and Circulatory Physiology. 305: H1120-30. PMID 23955715 DOI: 10.1152/Ajpheart.00288.2013  0.361
2013 Toth P, Tucsek Z, Sosnowska D, Gautam T, Mitschelen M, Tarantini S, Deak F, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1732-42. PMID 23942363 DOI: 10.1038/Jcbfm.2013.143  0.373
2013 Sonntag WE, Deak F, Ashpole N, Toth P, Csiszar A, Freeman W, Ungvari Z. Insulin-like growth factor-1 in CNS and cerebrovascular aging. Frontiers in Aging Neuroscience. 5: 27. PMID 23847531 DOI: 10.3389/Fnagi.2013.00027  0.517
2013 Ungvari Z, Podlutsky A, Sosnowska D, Tucsek Z, Toth P, Deak F, Gautam T, Csiszar A, Sonntag WE. Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 1443-57. PMID 23689827 DOI: 10.1093/Gerona/Glt057  0.315
2013 VanGuilder Starkey HD, Bixler GV, Sonntag WE, Freeman WM. Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus. Cellular and Molecular Neurobiology. 33: 483-8. PMID 23525710 DOI: 10.1007/S10571-013-9929-4  0.403
2013 VanGuilder Starkey HD, Sonntag WE, Freeman WM. Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition. The European Journal of Neuroscience. 37: 1643-58. PMID 23438185 DOI: 10.1111/Ejn.12165  0.403
2013 Ungvari Z, Tucsek Z, Sosnowska D, Toth P, Gautam T, Podlutsky A, Csiszar A, Losonczy G, Valcarcel-Ares MN, Sonntag WE, Csiszar A. Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 877-91. PMID 23239824 DOI: 10.1093/Gerona/Gls242  0.4
2013 Bailey-Downs LC, Tucsek Z, Toth P, Sosnowska D, Gautam T, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 780-92. PMID 23213032 DOI: 10.1093/Gerona/Gls238  0.327
2013 Toth P, Csiszar A, Sosnowska D, Tucsek Z, Cseplo P, Springo Z, Tarantini S, Sonntag WE, Ungvari Z, Koller A. Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. British Journal of Pharmacology. 168: 1878-88. PMID 23194285 DOI: 10.1111/Bph.12079  0.303
2013 Tucsek Z, Gautam T, Sonntag WE, Toth P, Saito H, Salomao R, Szabo C, Csiszar A, Ungvari Z. Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 652-60. PMID 23183901 DOI: 10.1093/Gerona/Gls232  0.357
2013 Csiszar A, Sosnowska D, Tucsek Z, Gautam T, Toth P, Losonczy G, Colman RJ, Weindruch R, Anderson RM, Sonntag WE, Ungvari Z. Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 235-49. PMID 22904098 DOI: 10.1093/Gerona/Gls158  0.302
2013 Ungvari Z, Csiszar A, Sosnowska D, Philipp EE, Campbell CM, McQuary PR, Chow TT, Coelho M, Didier ES, Gelino S, Holmbeck MA, Kim I, Levy E, Sonntag WE, Whitby PW, et al. Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 359-67. PMID 22904097 DOI: 10.1093/Gerona/Gls159  0.331
2012 VanGuilder Starkey HD, Van Kirk CA, Bixler GV, Imperio CG, Kale VP, Serfass JM, Farley JA, Yan H, Warrington JP, Han S, Mitschelen M, Sonntag WE, Freeman WM. Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging. Journal of Molecular Neuroscience : Mn. 48: 111-26. PMID 22562814 DOI: 10.1007/S12031-012-9783-8  0.411
2012 Sonntag WE, Csiszar A, deCabo R, Ferrucci L, Ungvari Z. Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 587-98. PMID 22522510 DOI: 10.1093/Gerona/Gls115  0.515
2012 Deak F, Sonntag WE. Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 611-25. PMID 22503992 DOI: 10.1093/Gerona/Gls118  0.49
2012 Warrington JP, Csiszar A, Mitschelen M, Lee YW, Sonntag WE. Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia. Plos One. 7: e30444. PMID 22279591 DOI: 10.1371/Journal.Pone.0030444  0.306
2012 Vanguilder HD, Bixler GV, Sonntag WE, Freeman WM. Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. Journal of Neurochemistry. 121: 77-98. PMID 22269040 DOI: 10.1111/J.1471-4159.2012.07671.X  0.412
2012 Valcarcel-Ares MN, Gautam T, Warrington JP, Bailey-Downs L, Sosnowska D, de Cabo R, Losonczy G, Sonntag WE, Ungvari Z, Csiszar A. Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 821-9. PMID 22219515 DOI: 10.1093/Gerona/Glr229  0.346
2012 Csiszar A, Sosnowska D, Wang M, Lakatta EG, Sonntag WE, Ungvari Z. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 811-20. PMID 22219513 DOI: 10.1093/Gerona/Glr228  0.425
2012 Nieves-Martinez E, Haynes K, Childers SR, Sonntag WE, Nicolle MM. Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats. Behavioural Brain Research. 227: 258-64. PMID 22085876 DOI: 10.1016/J.Bbr.2011.10.048  0.426
2012 Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn JC, Ballabh P, Koller A, Farley JA, Sonntag WE, Csiszar A, Ungvari Z. Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 553-64. PMID 22080499 DOI: 10.1093/Gerona/Glr197  0.469
2012 Bailey-Downs LC, Mitschelen M, Sosnowska D, Toth P, Pinto JT, Ballabh P, Valcarcel-Ares MN, Farley J, Koller A, Henthorn JC, Bass C, Sonntag WE, Ungvari Z, Csiszar A. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 313-29. PMID 22021391 DOI: 10.1093/Gerona/Glr164  0.453
2012 Molina DP, Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiology of Aging. 33: 1938-49. PMID 22015312 DOI: 10.1016/J.Neurobiolaging.2011.09.014  0.406
2011 VanGuilder HD, Bixler GV, Brucklacher RM, Farley JA, Yan H, Warrington JP, Sonntag WE, Freeman WM. Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment. Journal of Neuroinflammation. 8: 138. PMID 21989322 DOI: 10.1186/1742-2094-8-138  0.45
2011 Lee WH, Cho HJ, Sonntag WE, Lee YW. Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain. Radiation Research. 176: 753-60. PMID 21962003 DOI: 10.1667/Rr2647.1  0.326
2011 Yan H, Mitschelen M, Bixler GV, Brucklacher RM, Farley JA, Han S, Freeman WM, Sonntag WE. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. The Journal of Endocrinology. 211: 27-37. PMID 21750148 DOI: 10.1530/Joe-11-0200  0.446
2011 Ungvari Z, Bailey-Downs L, Gautam T, Sosnowska D, Wang M, Monticone RE, Telljohann R, Pinto JT, de Cabo R, Sonntag WE, Lakatta EG, Csiszar A. Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 66: 866-75. PMID 21622983 DOI: 10.1093/Gerona/Glr092  0.38
2011 Ungvari Z, Bailey-Downs L, Sosnowska D, Gautam T, Koncz P, Losonczy G, Ballabh P, de Cabo R, Sonntag WE, Csiszar A. Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. American Journal of Physiology. Heart and Circulatory Physiology. 301: H363-72. PMID 21602469 DOI: 10.1152/Ajpheart.01134.2010  0.408
2011 Mitschelen M, Yan H, Farley JA, Warrington JP, Han S, Hereñú CB, Csiszar A, Ungvari Z, Bailey-Downs LC, Bass CE, Sonntag WE. Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression. Neuroscience. 185: 50-60. PMID 21524689 DOI: 10.1016/J.Neuroscience.2011.04.032  0.423
2011 VanGuilder HD, Farley JA, Yan H, Van Kirk CA, Mitschelen M, Sonntag WE, Freeman WM. Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiology of Disease. 43: 201-12. PMID 21440628 DOI: 10.1016/J.Nbd.2011.03.012  0.406
2011 Ungvari Z, Sonntag WE, de Cabo R, Baur JA, Csiszar A. Mitochondrial protection by resveratrol. Exercise and Sport Sciences Reviews. 39: 128-32. PMID 21383627 DOI: 10.1097/Jes.0B013E3182141F80  0.313
2011 Groban L, Lin M, Kassik KA, Ingram RL, Sonntag WE. Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 21: 81-8. PMID 21371927 DOI: 10.1016/J.Ghir.2011.01.003  0.446
2011 Ungvari Z, Sosnowska D, Podlutsky A, Koncz P, Sonntag WE, Csiszar A. Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 66: 501-10. PMID 21350246 DOI: 10.1093/Gerona/Glr004  0.411
2011 Warrington JP, Csiszar A, Johnson DA, Herman TS, Ahmad S, Lee YW, Sonntag WE. Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in mice. American Journal of Physiology. Heart and Circulatory Physiology. 300: H736-44. PMID 21186274 DOI: 10.1152/Ajpheart.01024.2010  0.32
2011 Zuo Z, Lei H, Wang X, Wang Y, Sonntag W, Sun Z. Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. Age (Dordrecht, Netherlands). 33: 261-74. PMID 20830528 DOI: 10.1007/S11357-010-9176-2  0.43
2010 Ungvari Z, Sonntag WE, Csiszar A. Mitochondria and aging in the vascular system. Journal of Molecular Medicine (Berlin, Germany). 88: 1021-7. PMID 20714704 DOI: 10.1007/S00109-010-0667-5  0.369
2010 Ungvari Z, Gautam T, Koncz P, Henthorn JC, Pinto JT, Ballabh P, Yan H, Mitschelen M, Farley J, Sonntag WE, Csiszar A. Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 1145-56. PMID 20713653 DOI: 10.1093/Gerona/Glq147  0.454
2010 Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 1028-41. PMID 20576649 DOI: 10.1093/Gerona/Glq113  0.366
2010 Zhao W, Aboushwareb T, Turner C, Mathis C, Bennett C, Sonntag WE, Andersson KE, Christ G. Impaired bladder function in aging male rats. The Journal of Urology. 184: 378-85. PMID 20488483 DOI: 10.1016/J.Juro.2010.03.004  0.426
2010 Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, de Cabo R, Csiszar A. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. American Journal of Physiology. Heart and Circulatory Physiology. 299: H18-24. PMID 20418481 DOI: 10.1152/Ajpheart.00260.2010  0.307
2010 Lee WH, Sonntag WE, Lee YW. Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain. Neuroscience Letters. 476: 89-93. PMID 20385203 DOI: 10.1016/J.Neulet.2010.04.009  0.347
2010 VanGuilder HD, Yan H, Farley JA, Sonntag WE, Freeman WM. Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome. Journal of Neurochemistry. 113: 1577-88. PMID 20374424 DOI: 10.1111/J.1471-4159.2010.06719.X  0.434
2010 Nieves-Martinez E, Sonntag WE, Wilson A, Donahue A, Molina DP, Brunso-Bechtold J, Nicolle MM. Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. The Journal of Endocrinology. 204: 31-6. PMID 19815586 DOI: 10.1677/Joe-09-0323  0.471
2010 Apel PJ, Ma J, Callahan M, Northam CN, Alton TB, Sonntag WE, Li Z. Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats. Muscle & Nerve. 41: 335-41. PMID 19802878 DOI: 10.1002/Mus.21485  0.409
2009 Mitschelen M, Garteiser P, Carnes BA, Farley JA, Doblas S, Demoe JH, Warrington JP, Yan H, Nicolle MM, Towner R, Sonntag WE. Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents. Neuroscience. 164: 918-28. PMID 19735701 DOI: 10.1016/J.Neuroscience.2009.08.070  0.42
2009 Hereñú CB, Sonntag WE, Morel GR, Portiansky EL, Goya RG. The ependymal route for insulin-like growth factor-1 gene therapy in the brain. Neuroscience. 163: 442-7. PMID 19531373 DOI: 10.1016/J.Neuroscience.2009.06.024  0.395
2009 Adams MM, Elizabeth Forbes M, Constance Linville M, Riddle DR, Sonntag WE, Brunso-Bechtold JK. Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Growth Factors (Chur, Switzerland). 27: 181-8. PMID 19343576 DOI: 10.1080/08977190902863639  0.456
2009 Freeman WM, VanGuilder HD, Bennett C, Sonntag WE. Cognitive performance and age-related changes in the hippocampal proteome. Neuroscience. 159: 183-95. PMID 19135133 DOI: 10.1016/J.Neuroscience.2008.12.004  0.396
2009 Hua K, Forbes ME, Lichtenwalner RJ, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum. Glia. 57: 1062-71. PMID 19115393 DOI: 10.1002/Glia.20829  0.501
2009 Apel PJ, Alton T, Northam C, Ma J, Callahan M, Sonntag WE, Li Z. How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 27: 385-93. PMID 18853430 DOI: 10.1002/Jor.20773  0.313
2008 Groban L, Jobe H, Lin M, Houle T, Kitzman DA, Sonntag W. Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 63: 911-920. PMID 18840795 DOI: 10.1093/Gerona/63.9.911  0.384
2008 Adams MM, Shi L, Linville MC, Forbes ME, Long AB, Bennett C, Newton IG, Carter CS, Sonntag WE, Riddle DR, Brunso-Bechtold JK. Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Experimental Neurology. 211: 141-9. PMID 18342310 DOI: 10.1016/J.Expneurol.2008.01.016  0.571
2008 Ingraham JP, Forbes ME, Riddle DR, Sonntag WE. Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 63: 12-20. PMID 18245756 DOI: 10.1093/Gerona/63.1.12  0.801
2007 Braverman ER, Chen TJ, Prihoda TJ, Sonntag W, Meshkin B, Downs BW, Mengucci JF, Blum SH, Notaro A, Arcuri V, Varshavskiy M, Blum K. Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: evidence supported by structural equation modeling (SEM) parameter estimates. Age (Dordrecht, Netherlands). 29: 55-67. PMID 19424831 DOI: 10.1007/S11357-007-9030-3  0.484
2007 You T, Sonntag WE, Leng X, Carter CS. Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 1082-7. PMID 17921419 DOI: 10.1093/Gerona/62.10.1082  0.547
2006 Shi L, Adams MM, Long A, Carter CC, Bennett C, Sonntag WE, Nicolle MM, Robbins M, D'Agostino R, Brunso-Bechtold JK. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiation Research. 166: 892-9. PMID 17149974 DOI: 10.1667/Rr0588.1  0.344
2006 Ekenstedt KJ, Sonntag WE, Loeser RF, Lindgren BR, Carlson CS. Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Arthritis and Rheumatism. 54: 3850-8. PMID 17133593 DOI: 10.1002/Art.22254  0.422
2006 Sonntag WE, Bennett C, Ingram R, Donahue A, Ingraham J, Chen H, Moore T, Brunso-Bechtold JK, Riddle D. Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency. American Journal of Physiology. Endocrinology and Metabolism. 291: E604-10. PMID 16912061 DOI: 10.1152/Ajpendo.00012.2006  0.797
2006 Groban L, Pailes NA, Bennett CD, Carter CS, Chappell MC, Kitzman DW, Sonntag WE. Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 61: 28-35. PMID 16456192 DOI: 10.1093/Gerona/61.1.28  0.614
2006 Lichtenwalner RJ, Forbes ME, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis. Journal of Neuroscience Research. 83: 199-210. PMID 16385581 DOI: 10.1002/Jnr.20719  0.42
2006 Donahue AN, Aschner M, Lash LH, Syversen T, Sonntag WE. Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus. Mechanisms of Ageing and Development. 127: 57-63. PMID 16243379 DOI: 10.1016/J.Mad.2005.09.003  0.555
2005 Grill JD, Sonntag WE, Riddle DR. Dendritic stability in a model of adult-onset IGF-I deficiency. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 15: 337-48. PMID 16143551 DOI: 10.1016/J.Ghir.2005.07.002  0.512
2005 Kasper SO, Carter CS, Ferrario CM, Ganten D, Ferder LF, Sonntag WE, Gallagher PE, Diz DI. Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems. Physiological Genomics. 23: 311-7. PMID 16131528 DOI: 10.1152/Physiolgenomics.00163.2005  0.614
2005 Sonntag WE, Ramsey M, Carter CS. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Research Reviews. 4: 195-212. PMID 16024298 DOI: 10.1016/J.Arr.2005.02.001  0.804
2005 Ramsey MM, Adams MM, Ariwodola OJ, Sonntag WE, Weiner JL. Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. Journal of Neurophysiology. 94: 247-54. PMID 15985695 DOI: 10.1152/Jn.00768.2004  0.749
2005 Sonntag WE, Carter CS, Ikeno Y, Ekenstedt K, Carlson CS, Loeser RF, Chakrabarty S, Lee S, Bennett C, Ingram R, Moore T, Ramsey M. Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology. 146: 2920-32. PMID 15790724 DOI: 10.1210/En.2005-0058  0.777
2005 Shi L, Linville MC, Tucker EW, Sonntag WE, Brunso-Bechtold JK. Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus. Cerebral Cortex (New York, N.Y. : 1991). 15: 571-7. PMID 15319312 DOI: 10.1093/Cercor/Bhh158  0.45
2005 Ramsey M, Sonntag WE. Growth Hormone and Insulin-like Growth Factor-I and Their Interactions with Brain Circuits Involved in Cognitive Function The Somatotrophic Axis in Brain Function. 185-208. DOI: 10.1016/B978-012088484-1/50017-3  0.706
2005 Carter CS, Sonntag WE. Growth Hormone, Insulin-Like Growth Factor-1, and the Biology of Aging Handbook of the Biology of Aging. 534-569. DOI: 10.1016/B978-012088387-5/50023-6  0.584
2004 Ramsey MM, Weiner JL, Moore TP, Carter CS, Sonntag WE. Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning. Neuroscience. 129: 119-27. PMID 15489035 DOI: 10.1016/J.Neuroscience.2004.08.001  0.805
2004 Butler RN, Sprott R, Warner H, Bland J, Feuers R, Forster M, Fillit H, Harman SM, Hewitt M, Hyman M, Johnson K, Kligman E, McClearn G, Nelson J, Richardson A, ... Sonntag W, et al. Biomarkers of aging: from primitive organisms to humans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 59: B560-7. PMID 15215265 DOI: 10.1093/Gerona/59.6.B560  0.372
2004 Carter CS, Cesari M, Ambrosius WT, Hu N, Diz D, Oden S, Sonntag WE, Pahor M. Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 59: 416-23. PMID 15123750 DOI: 10.1093/Gerona/59.5.B416  0.521
2003 Riddle DR, Sonntag WE, Lichtenwalner RJ. Microvascular plasticity in aging. Ageing Research Reviews. 2: 149-68. PMID 12605958 DOI: 10.1016/S1568-1637(02)00064-8  0.387
2002 Sonntag WE, Ramsey MM. Of worms, flies, dwarfs, and things that go bump in the night. Science of Aging Knowledge Environment : Sage Ke. 2002: pe17. PMID 14603010 DOI: 10.1126/Sageke.2002.43.Pe17  0.718
2002 Ramsey MM, Ingram RL, Cashion AB, Ng AH, Cline JM, Parlow AF, Sonntag WE. Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis. Endocrinology. 143: 4139-42. PMID 12239127 DOI: 10.1210/En.2002-220717  0.729
2002 Khan AS, Sane DC, Wannenburg T, Sonntag WE. Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovascular Research. 54: 25-35. PMID 12062358 DOI: 10.1016/S0008-6363(01)00533-8  0.677
2002 Khan AS, Sane DC, Wannenburg T, Sonntag WE. Repolarization abnormalities in heart failure Cardiovascular Research. 54: 11-12. PMID 12062355 DOI: 10.1016/S0008-6363(02)00249-3  0.357
2002 Carter CS, Ramsey MM, Sonntag WE. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends in Genetics : Tig. 18: 295-301. PMID 12044358 DOI: 10.1016/S0168-9525(02)02696-3  0.775
2002 Carter CS, Sonntag WE, Onder G, Pahor M. Physical performance and longevity in aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 57: B193-7. PMID 11983716 DOI: 10.1093/Gerona/57.5.B193  0.578
2002 Carter CS, Ramsey MM, Ingram RL, Cashion AB, Cefalu WT, Wang ZQ, Sonntag WE. Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 57: B177-88. PMID 11983714 DOI: 10.1093/Gerona/57.5.B177  0.785
2002 Shi L, Poe BH, Constance Linville M, Sonntag WE, Brunso-Bechtold JK. Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex. Brain Research. 931: 32-40. PMID 11897086 DOI: 10.1016/S0006-8993(02)02249-7  0.358
2002 Poe BH, Linville MC, Sonntag WE, Brunso-Bechtold JK. Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26: 97-102. PMID 11853126 DOI: 10.1016/S0278-5846(01)00225-1  0.446
2001 Poe BH, Linville C, Riddle DR, Sonntag WE, Brunso-Bechtold JK. Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus. Neuroscience. 107: 231-8. PMID 11731097 DOI: 10.1016/S0306-4522(01)00341-4  0.394
2001 Lichtenwalner RJ, Forbes ME, Bennett SA, Lynch CD, Sonntag WE, Riddle DR. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience. 107: 603-13. PMID 11720784 DOI: 10.1016/S0306-4522(01)00378-5  0.499
2001 Khan AS, Lynch CD, Sane DC, Willingham MC, Sonntag WE. Growth hormone increases regional coronary blood flow and capillary density in aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: B364-71. PMID 11487595 DOI: 10.1093/Gerona/56.8.B364  0.6
2001 Wannenburg T, Khan AS, Sane DC, Willingham MC, Faucette T, Sonntag WE. Growth hormone reverses age-related cardiac myofilament dysfunction in rats. American Journal of Physiology. Heart and Circulatory Physiology. 281: H915-22. PMID 11454598 DOI: 10.1152/Ajpheart.2001.281.2.H915  0.572
2001 Carter CS, Pahor M, Sonntag WE. Assessment of physical function in aging rodents: a strategy for improving preclinical testing. Experimental Aging Research. 27: 271-82. PMID 11441648 DOI: 10.1080/036107301300208709  0.512
2001 Lynch CD, Lyons D, Khan A, Bennett SA, Sonntag WE. Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals. Endocrinology. 142: 506-9. PMID 11145617 DOI: 10.1210/Endo.142.1.8053  0.642
2001 Sonntag WE, Brunso-Bechtold JK, Riddle DR. Age-related decreases in growth hormone and insulin-like growth factor (IGF)-I: Implications for brain aging Rejuvenation Research. 4: 311-329. DOI: 10.1089/10945450152850641  0.539
2001 Sonntag WE, Brunso-Bechtold JK, Riddle DR. Age-related decreases in growth hormone and insulin-like growth factor (IGF)-1: Implications for brain aging Journal of Anti-Aging Medicine. 4: 311-329.  0.439
2000 Sonntag WE, Lynch C, Thornton P, Khan A, Bennett S, Ingram R. The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. Journal of Anatomy. 197: 575-85. PMID 11197531 DOI: 10.1017/S002187829900713X  0.689
2000 Loeser RF, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis and Rheumatism. 43: 2110-20. PMID 11014363 DOI: 10.1002/1529-0131(200009)43:9<2110::Aid-Anr23>3.0.Co;2-U  0.485
2000 Cefalu WT, Wang ZQ, Bell-Farrow AD, Terry JG, Sonntag W, Waite M, Parks J. Chronic caloric restriction alters muscle membrane fatty acid content. Experimental Gerontology. 35: 331-341. PMID 10832054 DOI: 10.1016/S0531-5565(00)00093-0  0.305
2000 Thornton PL, Ingram RL, Sonntag WE. Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 55: B106-12. PMID 10737685 DOI: 10.1093/Gerona/55.2.B106  0.52
2000 Sonntag WE, Bennett SA, Khan AS, Thornton PL, Xu X, Ingram RL, Brunso-Bechtold JK. Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats. Brain Research Bulletin. 51: 331-8. PMID 10704784 DOI: 10.1016/S0361-9230(99)00259-2  0.61
1999 Sonntag WE, Lynch CD, Cefalu WT, Ingram RL, Bennett SA, Thornton PL, Khan AS. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 54: B521-38. PMID 10647962 DOI: 10.1093/Gerona/54.12.B521  0.675
1999 Lynch CD, Cooney PT, Bennett SA, Thornton PL, Khan AS, Ingram RL, Sonntag WE. Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats. Neurobiology of Aging. 20: 191-200. PMID 10537028 DOI: 10.1016/S0197-4580(99)00032-9  0.564
1999 Sonntag WE, Lynch CD, Bennett SA, Khan AS, Thornton PL, Cooney PT, Ingram RL, McShane T, Brunso-Bechtold JK. Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. Neuroscience. 88: 269-79. PMID 10051206 DOI: 10.1016/S0306-4522(98)00192-4  0.644
1998 Wang ZQ, Bell-Farrow AD, Sonntag W, Cefalu WT. Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats. Experimental Gerontology. 32: 671-84. PMID 9785093 DOI: 10.1016/S0531-5565(97)00054-5  0.425
1998 Markowska AL, Mooney M, Sonntag WE. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience. 87: 559-69. PMID 9758223 DOI: 10.1016/S0306-4522(98)00143-2  0.493
1998 Niblock MM, Brunso-Bechtold JK, Lynch CD, Ingram RL, McShane T, Sonntag WE. Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain. Brain Research. 804: 79-86. PMID 9729292 DOI: 10.1016/S0006-8993(98)00645-3  0.495
1997 Sonntag WE, Lynch CD, Cooney PT, Hutchins PM. Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology. 138: 3515-20. PMID 9231806 DOI: 10.1210/Endo.138.8.5330  0.502
1996 Xu X, Sonntag WE. Growth hormone and aging: Regulation, signal transduction and replacement therapy. Trends in Endocrinology and Metabolism: Tem. 7: 145-50. PMID 18406741 DOI: 10.1016/1043-2760(96)00043-4  0.49
1996 Xu X, Sonntag WE. Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction. The American Journal of Physiology. 271: E903-9. PMID 8944679 DOI: 10.1152/Ajpendo.1996.271.5.E903  0.487
1996 Breese CR, D'Costa A, Rollins YD, Adams C, Booze RM, Sonntag WE, Leonard S. Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus. The Journal of Comparative Neurology. 369: 388-404. PMID 8743420 DOI: 10.1002/(Sici)1096-9861(19960603)369:3<388::Aid-Cne5>3.0.Co;2-1  0.359
1996 Xu X, Sonntag WE. Moderate caloric restriction prevents the age-related decline in growth hormone receptor signal transduction. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 51: B167-74. PMID 8612101 DOI: 10.1093/Gerona/51A.2.B167  0.486
1995 Xu X, Ingram RL, Sonntag WE. Ethanol suppresses growth hormone-mediated cellular responses in liver slices. Alcoholism, Clinical and Experimental Research. 19: 1246-51. PMID 8561297 DOI: 10.1111/J.1530-0277.1995.Tb01607.X  0.41
1995 Xu X, Bennett SA, Ingram RL, Sonntag WE. Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age. Endocrinology. 136: 4551-7. PMID 7664676 DOI: 10.1210/Endo.136.10.7664676  0.487
1995 Sonntag WE, Xu X, Ingram RL, D'Costa A. Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals. Neuroendocrinology. 61: 601-8. PMID 7617139 DOI: 10.1159/000126885  0.494
1995 D'Costa AP, Xu X, Ingram RL, Sonntag WE. Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats. Neuroscience. 65: 805-13. PMID 7609879 DOI: 10.1016/0306-4522(94)00495-Q  0.517
1995 Cefalu WT, Bell-Farrow AD, Wang ZQ, Sonntag WE, Fu MX, Baynes JW, Thorpe SR. Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 50: B337-41. PMID 7583789 DOI: 10.1093/Gerona/50A.6.B337  0.333
1995 Breese CR, Sonntag WE. Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats. Alcoholism, Clinical and Experimental Research. 19: 867-73. PMID 7485832 DOI: 10.1111/J.1530-0277.1995.Tb00960.X  0.338
1994 Breese CR, D'Costa A, Sonntag WE. Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain. Neuroscience. 63: 579-89. PMID 7891866 DOI: 10.1016/0306-4522(94)90551-7  0.43
1993 D'Costa AP, Ingram RL, Lenham JE, Sonntag WE. The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing. Journal of Reproduction and Fertility. Supplement. 46: 87-98. PMID 8315618  0.454
1993 D'Costa AP, Lenham JE, Ingram RL, Sonntag WE. Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors. Annals of the New York Academy of Sciences. 692: 253-5. PMID 8215027 DOI: 10.1111/J.1749-6632.1993.Tb26225.X  0.45
1993 D'Costa AP, Lenham JE, Ingram RL, Sonntag WE. Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats. Mechanisms of Ageing and Development. 71: 59-71. PMID 7508538 DOI: 10.1016/0047-6374(93)90035-P  0.507
1992 Sonntag WE, Lenham JE, Ingram RL. Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1. Journal of Gerontology. 47: B159-63. PMID 1387410 DOI: 10.1093/Geronj/47.5.B159  0.481
1991 Spik KW, Boyd RL, Sonntag WE. Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture. Journal of Gerontology. 46: B72-7. PMID 1997567 DOI: 10.1093/Geronj/46.2.B72  0.441
1991 Breese CR, Ingram RL, Sonntag WE. Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. Journal of Gerontology. 46: B180-7. PMID 1716275 DOI: 10.1093/Geronj/46.5.B180  0.481
1991 D'Costa A, Breese CR, Boyd RL, Booze RM, Sonntag WE. Attenuation of Fos-like immunoreactivity induced by a single electroconvulsive shock in brains of aging mice. Brain Research. 567: 204-11. PMID 1687805 DOI: 10.1016/0006-8993(91)90797-Y  0.373
1991 Breese CR, D'Costa A, Booze RM, Sonntag WE. Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice. Advances in Experimental Medicine and Biology. 293: 449-58. PMID 1662866 DOI: 10.1007/978-1-4684-5949-4_40  0.403
1990 Sonntag WE, Boyd RL, Booze RM. Somatostatin gene expression in hypothalamus and cortex of aging male rats. Neurobiology of Aging. 11: 409-16. PMID 1974326 DOI: 10.1016/0197-4580(90)90007-M  0.398
1989 Sonntag WE, Boyd RL. Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release. Alcoholism, Clinical and Experimental Research. 13: 3-7. PMID 2646974 DOI: 10.1111/J.1530-0277.1989.Tb00274.X  0.429
1989 Spik K, Sonntag WE. Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity. Neuroendocrinology. 50: 489-94. PMID 2575235 DOI: 10.1159/000125269  0.503
1988 Sonntag WE, Boyd RL. Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1. Life Sciences. 43: 1325-30. PMID 3172983 DOI: 10.1016/0024-3205(88)90588-7  0.351
1988 Sonntag WE, Gough MA. Growth hormone releasing hormone induced release of growth hormone in aging male rats: dependence on pharmacological manipulation and endogenous somatostatin release. Neuroendocrinology. 47: 482-8. PMID 2840597 DOI: 10.1159/000124959  0.464
1987 Sonntag WE, Goliszek AG, Brodish A, Eldridge JC. Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo. Endocrinology. 120: 2308-15. PMID 3032584 DOI: 10.1210/endo-120-6-2308  0.327
1986 Sonntag WE, Gottschall PE, Meites J. Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro. Brain Research. 380: 229-34. PMID 2875760 DOI: 10.1016/0006-8993(86)90217-9  0.401
1985 Sonntag WE, Hylka VW, Meites J. Growth hormone restores protein synthesis in skeletal muscle of old male rats. Journal of Gerontology. 40: 689-94. PMID 4056323 DOI: 10.1093/Geronj/40.6.689  0.38
1985 Forman LJ, Sonntag WE, Hylka VW, Meites J. Mediation by gonadal steroids of plasma beta-endorphin and LH in castrated female and male rats. Peptides. 6: 835-9. PMID 2934689 DOI: 10.1016/0196-9781(85)90310-9  0.354
1985 Forman LJ, Sonntag WE, Hylka VW, Meites J. Pituitary growth hormone and hypothalamic somatostatin in young female rats versus old constant estrous female rats. Experientia. 41: 653-4. PMID 2860005 DOI: 10.1007/BF02007705  0.331
1984 Sonntag WE, Forman LJ, Fiori JM, Hylka VW, Meites J. Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors. Endocrinology. 114: 1657-64. PMID 6325129 DOI: 10.1210/Endo-114-5-1657  0.385
1984 Hylka VW, Sonntag WE, Meites J. Reduced ability of old male rats to release ACTH and corticosterone in response to CRF administration. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 175: 1-4. PMID 6320204 DOI: 10.3181/00379727-175-1-Rc1  0.383
1983 Sonntag WE, Hylka VW, Meites J. Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44). Endocrinology. 113: 2305-7. PMID 6416817 DOI: 10.1210/Endo-113-6-2305  0.424
1983 Steger RW, Sonntag WE, Peluso JJ, Meites J. Effects of ovariectomy and steroid replacement on hypothalamic LHRH content in aging female rats. Neurobiology of Aging. 4: 53-7. PMID 6348573 DOI: 10.1016/0197-4580(83)90054-4  0.409
1983 Forman LJ, Sonntag WE, Hylka VW, Meites J. Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young female rats on the day of estrus and intact and chronically castrated old constant estrous female rats. Life Sciences. 33: 993-9. PMID 6310292 DOI: 10.1016/0024-3205(83)90756-7  0.333
1983 Forman LJ, Sonntag WE, Meites J. Elevation of plasma LH in response to systemic injection of beta-endorphin antiserum in adult male rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 173: 14-6. PMID 6304744 DOI: 10.3181/00379727-173-1-Rc1  0.316
1982 Sonntag WE, Forman LJ, Miki N, Trapp JM, Gottschall PE, Meites J. L-dopa restores amplitude of growth hormone pulses in old male rats to that observed in young male rats. Neuroendocrinology. 34: 163-8. PMID 6122169 DOI: 10.1159/000123295  0.381
1981 Miki N, Sonntag WE, Forman LJ, Meites J. Suppression by naloxone of rise in plasma growth hormone and prolactin induced by sucking. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 168: 330-3. PMID 7198792 DOI: 10.3181/00379727-168-41281  0.328
1981 Forman LJ, Sonntag WE, Miki N, Ramos T, Meites J. Comparison of the effects of central acting drugs on prolactin release in young and old male rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 167: 354-8. PMID 6454894 DOI: 10.3181/00379727-167-41178  0.339
1981 Forman LJ, Sonntag WE, Van Vugt DA, Meites J. Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young and old male rats. Neurobiology of Aging. 2: 281-4. PMID 6278345 DOI: 10.1016/0197-4580(81)90036-1  0.312
1981 Sonntag WE, Forman LJ, Miki N, Steger RW, Ramos T, Arimura A, Meites J. Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats. Neuroendocrinology. 33: 73-8. PMID 6115331 DOI: 10.1159/000123205  0.412
1980 Huang HH, Steger RW, Sonntag WE, Meites J. Positive Feedback by Ovarian Hormones on Prolactin and LH in Old Versus Young Female Rats. Neurobiology of Aging. 1: 141-3. PMID 24279937 DOI: 10.1016/0197-4580(80)90007-X  0.397
1980 Sonntag WE, Steger RW, Forman LJ, Meites J. Decreased pulsatile release of growth hormone in old male rats. Endocrinology. 107: 1875-9. PMID 7428695 DOI: 10.1210/Endo-107-6-1875  0.393
1980 Steger RW, Sonntag WE, Van Vugt DA, Forman LJ, Meites J. Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin. Life Sciences. 27: 747-53. PMID 7412501 DOI: 10.1016/0024-3205(80)90328-8  0.381
1980 Gerall AA, Dunlap JL, Sonntag WE. Reproduction in aging normal and neonatally androgenized female rats. Journal of Comparative and Physiological Psychology. 94: 556-63. PMID 7391285 DOI: 10.1037/H0077690  0.743
1980 Forman LJ, Sonntag WE, Miki N, Meites J. Maintenance by L-DOPA treatment of estrous cycles and LH response to estrogen in aging female rats. Experimental Aging Research. 6: 547-54. PMID 7194183 DOI: 10.1080/03610738008258386  0.361
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