Michael Brandt - Publications

Affiliations: 
Janssen Research & Development 

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Parsons WH, Calvo RR, Cheung W, Lee YK, Patel S, Liu J, Youngman MA, Dax SL, Stone D, Qin N, Hutchinson T, Lubin ML, Zhang SP, Finley M, Liu Y, ... Brandt MR, et al. Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). Journal of Medicinal Chemistry. 58: 3859-74. PMID 25850459 DOI: 10.1021/acs.jmedchem.5b00132  0.68
2014 Winters MP, Subasinghe N, Wall M, Beck E, Brandt MR, Finley MF, Liu Y, Lubin ML, Neeper MP, Qin N, Flores CM, Sui Z. Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 2057-61. PMID 24726803 DOI: 10.1016/j.bmcl.2014.03.063  0.68
2014 Winters MP, Subasinghe N, Wall M, Beck E, Brandt MR, Finley MF, Liu Y, Lubin ML, Neeper MP, Qin N, Flores CM, Sui Z. Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel. Bioorganic & Medicinal Chemistry Letters. 24: 2053-6. PMID 24726802 DOI: 10.1016/j.bmcl.2014.03.062  0.68
2013 Zhu B, Xia M, Xu X, Ludovici DW, Tennakoon M, Youngman MA, Matthews JM, Dax SL, Colburn RW, Qin N, Hutchinson TL, Lubin ML, Brandt MR, Stone DJ, Flores CM, et al. Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists. Bioorganic & Medicinal Chemistry Letters. 23: 2234-7. PMID 23411075 DOI: 10.1016/j.bmcl.2013.01.062  0.68
2012 Brandt MR, Beyer CE, Stahl SM. TRPV1 Antagonists and Chronic Pain: Beyond Thermal Perception. Pharmaceuticals (Basel, Switzerland). 5: 114-32. PMID 24288084 DOI: 10.3390/ph5020114  0.68
2012 Subasinghe NL, Wall MJ, Winters MP, Qin N, Lubin ML, Finley MF, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z. A novel series of pyrazolylpiperidine N-type calcium channel blockers. Bioorganic & Medicinal Chemistry Letters. 22: 4080-3. PMID 22608964 DOI: 10.1016/j.bmcl.2012.04.075  0.68
2012 Matthews JM, Qin N, Colburn RW, Dax SL, Hawkins M, McNally JJ, Reany L, Youngman MA, Baker J, Hutchinson T, Liu Y, Lubin ML, Neeper M, Brandt MR, Stone DJ, et al. The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists. Bioorganic & Medicinal Chemistry Letters. 22: 2922-6. PMID 22421018 DOI: 10.1016/j.bmcl.2012.02.060  0.68
2010 Codd EE, Baker J, Brandt MR, Bryant S, Cai C, Carson JR, Chevalier KM, Colburn RW, Coogan TP, Dax SL, Decorte B, Kemmerer M, Legrand EK, Lenhard JM, Leone AM, et al. Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 117: 493-504. PMID 20616206 DOI: 10.1093/Toxsci/Kfq200  0.68
2010 Codd EE, Ma J, Zhang SP, Stone DJ, Colburn RW, Brandt MR, Chevalier KM, Zhu Y, Peng S, Cai C, Acton PD, Flores CM. Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range. Pharmacology, Biochemistry, and Behavior. 96: 130-5. PMID 20438745 DOI: 10.1016/J.Pbb.2010.04.020  0.68
2009 Baudy RB, Butera JA, Abou-Gharbia MA, Chen H, Harrison B, Jain U, Magolda R, Sze JY, Brandt MR, Cummons TA, Kowal D, Pangalos MN, Zupan B, Hoffmann M, May M, et al. Prodrugs of perzinfotel with improved oral bioavailability. Journal of Medicinal Chemistry. 52: 771-8. PMID 19146418 DOI: 10.1021/jm8011799  0.68
2008 Cheung WS, Calvo RR, Tounge BA, Zhang SP, Stone DR, Brandt MR, Hutchinson T, Flores CM, Player MR. Discovery of piperidine carboxamide TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 18: 4569-72. PMID 18662879 DOI: 10.1016/j.bmcl.2008.07.035  0.68
2008 Jetter MC, McNally JJ, Youngman MA, McDonnell ME, Dubin AE, Nasser N, Zhang SP, Codd EE, Colburn RW, Stone DR, Brandt MR, Flores CM, Dax SL. N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorganic & Medicinal Chemistry Letters. 18: 2730-4. PMID 18359227 DOI: 10.1016/j.bmcl.2008.02.075  0.68
2008 Schechter LE, Lin Q, Smith DL, Zhang G, Shan Q, Platt B, Brandt MR, Dawson LA, Cole D, Bernotas R, Robichaud A, Rosenzweig-Lipson S, Beyer CE. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1323-35. PMID 17625499 DOI: 10.1038/sj.npp.1301503  0.68
2008 Jetter MC, McNally JJ, Youngman MA, McDonnell ME, Dubin AE, Nasser N, Zhang SP, Codd EE, Colburn RW, Stone DR, Brandt MR, Flores CM, Dax SL. Corrigendum to "N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1)" [Bioorg. Med. Chem. Lett. 18 (2008) 2730-2734] (DOI:10.1016/j.bmcl.2008.02.075) Bioorganic and Medicinal Chemistry Letters. 18: 4254. DOI: 10.1016/j.bmcl.2008.05.107  0.68
2007 Colburn RW, Lubin ML, Stone DJ, Wang Y, Lawrence D, D'Andrea MR, Brandt MR, Liu Y, Flores CM, Qin N. Attenuated cold sensitivity in TRPM8 null mice. Neuron. 54: 379-86. PMID 17481392 DOI: 10.1016/j.neuron.2007.04.017  0.68
2007 Leventhal L, Smith V, Hornby G, Andree TH, Brandt MR, Rogers KE. Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain. The Journal of Pharmacology and Experimental Therapeutics. 320: 1178-85. PMID 17142646 DOI: 10.1124/jpet.106.109728  0.68
2006 Leventhal L, Brandt MR, Cummons TA, Piesla MJ, Rogers KE, Harris HA. An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain. European Journal of Pharmacology. 553: 146-8. PMID 17056036 DOI: 10.1016/j.ejphar.2006.09.033  0.68
2006 Negus SS, Vanderah TW, Brandt MR, Bilsky EJ, Becerra L, Borsook D. Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. The Journal of Pharmacology and Experimental Therapeutics. 319: 507-14. PMID 16751251 DOI: 10.1124/Jpet.106.106377  0.68
2006 Smith VA, Beyer CE, Brandt MR. Neurochemical changes in the RVM associated with peripheral inflammatory pain stimuli. Brain Research. 1095: 65-72. PMID 16730668 DOI: 10.1016/j.brainres.2006.04.018  0.68
2005 Brandt MR, Cummons TA, Potestio L, Sukoff SJ, Rosenzweig-Lipson S. Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity. The Journal of Pharmacology and Experimental Therapeutics. 313: 1379-86. PMID 15764736 DOI: 10.1124/jpet.105.084467  0.68
2003 Negus SS, Brandt MR, Gatch MB, Mello NK. Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine. Drug and Alcohol Dependence. 70: 17-27. PMID 12681522 DOI: 10.1016/S0376-8716(02)00331-9  0.68
2003 Butera JA, Brandt MR. Chapter 1. Current and emerging opportunities for the treatment of neuropathic pain Annual Reports in Medicinal Chemistry. 38: 1-10.  0.68
2002 Harris IR, Siefken W, Beck-Oldach K, Brandt M, Wittern KP, Pollet D. Comparison of activities dependent on glutathione S-transferase and cytochrome P-450 IA1 in cultured keratinocytes and reconstructed epidermal models. Skin Pharmacology and Applied Skin Physiology. 15: 59-67. PMID 12476009 DOI: 10.1159/000066676  0.68
2002 Negus SS, Bidlack JM, Mello NK, Furness MS, Rice KC, Brandt MR. Delta opioid antagonist effects of buprenorphine in rhesus monkeys. Behavioural Pharmacology. 13: 557-70. PMID 12409994 DOI: 10.1097/00008877-200211000-00005  0.68
2002 Galici R, Brandt MR, France CP. Characterization of the discriminative stimulus effects of buprenorphine in pigeons. Psychopharmacology. 160: 132-9. PMID 11875630 DOI: 10.1007/S00213-001-0943-8  0.68
2001 Brandt MR, Furness MS, Rice KC, Fischer BD, Negus SS. Studies of tolerance and dependence with the delta-opioid agonist SNC80 in rhesus monkeys responding under a schedule of food presentation. The Journal of Pharmacology and Experimental Therapeutics. 299: 629-37. PMID 11602675  0.68
2001 Brandt MR, Furness MS, Mello NK, Rice KC, Negus SS. Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity. The Journal of Pharmacology and Experimental Therapeutics. 296: 939-46. PMID 11181927  0.68
2000 Brandt MR, France CP. Chronic l-alpha-acetylmethadol (LAAM) in rhesus monkeys: tolerance and cross-tolerance to the antinociceptive, ventilatory, and rate-decreasing effects of opioids. The Journal of Pharmacology and Experimental Therapeutics. 294: 168-78. PMID 10871309  0.68
2000 Brandt MR, Galici R, France CP. The discriminative stimulus effects of morphine in pigeons responding under a progressive ratio schedule of food presentation. Behavioural Pharmacology. 11: 15-28. PMID 10821205  0.68
1999 Negus SS, Brandt MR, Mello NK. Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 291: 60-9. PMID 10490887  0.68
1999 Brandt MR, Negus SS, Mello NK, Furness MS, Zhang X, Rice KC. Discriminative stimulus effects of the nonpeptidic delta-opioid agonist SNC80 in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 290: 1157-64. PMID 10454490  0.68
1998 Brandt MR, France CP. Chronic l-alpha acetylmethadol in rhesus monkeys: discriminative stimulus and other behavioral measures of dependence and withdrawal. The Journal of Pharmacology and Experimental Therapeutics. 287: 1029-37. PMID 9864289  0.68
1998 Lelas S, Gerak LR, Landers LK, Brandt MR, Bagley JR, Brockunier LL, France CP. Pharmacological profile of a deuterium-substituted mirfentanil derivative, OHM10579, in rhesus monkeys. Pharmacology, Biochemistry, and Behavior. 60: 665-75. PMID 9678650 DOI: 10.1016/S0091-3057(98)00046-X  0.68
1998 Gerak LR, Brandt MR, France CP. Studies on benzodiazepines and opioids administered alone and in combination in rhesus monkeys: ventilation and drug discrimination. Psychopharmacology. 137: 164-74. PMID 9630003 DOI: 10.1007/S002130050606  0.68
1998 France CP, Ahn SC, Brockunier LL, Bagley JR, Brandt MR, Winsauer PJ, Moerschbaecher JM. Behavioral effects and binding affinities of the fentanyl derivative OHM3507. Pharmacology, Biochemistry, and Behavior. 59: 295-303. PMID 9476973 DOI: 10.1016/S0091-3057(97)00417-6  0.68
1997 Brandt MR, Cabansag SR, France CP. Discriminative stimulus effects of l-alpha-acetylmethadol (LAAM), buprenorphine and methadone in morphine-treated rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 282: 574-84. PMID 9262317  0.68
1996 Brandt MR, France CP. Discriminative stimulus effects on enadoline in pigeons. The Journal of Pharmacology and Experimental Therapeutics. 277: 960-7. PMID 8627579  0.68
1994 Pape WJW, Brandt M, Pfannenbecker U. Combined in vitro assay for photohaemolysis and haemoglobin oxidation as part of a phototoxicity test system assessed with various phototoxic substances Toxicology in Vitro. 8: 755-757. DOI: 10.1016/0887-2333(94)90060-4  0.68
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