Joe Tsien - Publications

Medical College of Georgia, Augusta, GA, United States 
Learning and Memory

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wang H, Xie K, Xie L, Li X, Li M, Lyu C, Chen H, Chen Y, Liu X, Tsien J, Liu T. Functional Brain Connectivity Revealed by Sparse Coding of Large-Scale Local Field Potential Dynamics. Brain Topography. PMID 30341589 DOI: 10.1007/s10548-018-0682-3  1
2018 Wang H, Xie K, Lian Z, Cui Y, Chen Y, Zhang J, Xie L, Tsien J, Liu T. Large-scale Circuitry Interactions upon Earthquake Experiences Revealed by Recurrent Neural Networks. Ieee Transactions On Neural Systems and Rehabilitation Engineering : a Publication of the Ieee Engineering in Medicine and Biology Society. PMID 30296236 DOI: 10.1109/TNSRE.2018.2872919  0.88
2018 Liu J, Lyu C, Li M, Liu T, Song S, Tsien JZ. Neural coding of food experiences in the amygdala. Neurobiology of Learning and Memory. PMID 30125697 DOI: 10.1016/j.nlm.2018.08.012  1
2018 Cao T, Zhou X, Zheng X, Cui Y, Tsien JZ, Li C, Wang H. Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice. Frontiers in Aging Neuroscience. 10: 137. PMID 29867447 DOI: 10.3389/fnagi.2018.00137  0.84
2018 Li M, Xie K, Kuang H, Liu J, Wang D, Fox GE, Shi Z, Chen L, Zhao F, Mao Y, Tsien JZ. Neural Coding of Cell Assemblies via Spike-Timing Self-Information. Cerebral Cortex (New York, N.Y. : 1991). PMID 29688285 DOI: 10.1093/cercor/bhy081  1
2017 Fox GE, Li M, Zhao F, Tsien JZ. Distinct retrosplenial cortex cell populations and their spike dynamics during ketamine-induced unconscious state. Plos One. 12: e0187198. PMID 29073221 DOI: 10.1371/journal.pone.0187198  1
2017 Li M, Tsien JZ. Neural Code-Neural Self-information Theory on How Cell-Assembly Code Rises from Spike Time and Neuronal Variability. Frontiers in Cellular Neuroscience. 11: 236. PMID 28912685 DOI: 10.3389/fncel.2017.00236  1
2017 Li Y, Chen H, Jiang X, Li X, Lv J, Peng H, Tsien JZ, Liu T. Discover mouse gene coexpression landscapes using dictionary learning and sparse coding. Brain Structure & Function. PMID 28664394 DOI: 10.1007/s00429-017-1460-9  0.68
2017 Li Y, Chen H, Jiang X, Li X, Lv J, Li M, Peng H, Tsien JZ, Liu T. Transcriptome Architecture of Adult Mouse Brain Revealed by Sparse Coding of Genome-Wide In Situ Hybridization Images. Neuroinformatics. PMID 28608010 DOI: 10.1007/s12021-017-9333-1  1
2016 Zhao F, Li M, Jiang Z, Tsien JZ, Lu Z. Camera-Based, Non-Contact, Vital-Signs Monitoring Technology May Provide a Way for the Early Prevention of SIDS in Infants. Frontiers in Neurology. 7: 236. PMID 28066320 DOI: 10.3389/fneur.2016.00236  1
2016 Xie K, Fox GE, Liu J, Lyu C, Lee JC, Kuang H, Jacobs S, Li M, Liu T, Song S, Tsien JZ. Brain Computation Is Organized via Power-of-Two-Based Permutation Logic. Frontiers in Systems Neuroscience. 10: 95. PMID 27895562 DOI: 10.3389/fnsys.2016.00095  1
2016 Lee JC, Wang LP, Tsien JZ. Dopamine Rebound-Excitation Theory: Putting Brakes on PTSD. Frontiers in Psychiatry. 7: 163. PMID 27729874 DOI: 10.3389/fpsyt.2016.00163  0.88
2016 Jacobs S, Tsien JZ. Adult forebrain NMDA receptors gate social motivation and social memory. Neurobiology of Learning and Memory. PMID 27575297 DOI: 10.1016/j.nlm.2016.08.019  0.6
2016 Xie K, Fox GE, Liu J, Tsien JZ. 512-Channel and 13-Region Simultaneous Recordings Coupled with Optogenetic Manipulation in Freely Behaving Mice. Frontiers in Systems Neuroscience. 10: 48. PMID 27378865 DOI: 10.3389/fnsys.2016.00048  0.88
2016 Li M, Liu J, Tsien JZ. Theory of Connectivity: Nature and Nurture of Cell Assemblies and Cognitive Computation. Frontiers in Neural Circuits. 10: 34. PMID 27199674 DOI: 10.3389/fncir.2016.00034  1
2016 Tsien JZ. Cre-Lox Neurogenetics: 20 Years of Versatile Applications in Brain Research and Counting…. Frontiers in Genetics. 7: 19. PMID 26925095 DOI: 10.3389/fgene.2016.00019  1
2016 Hua XY, Qiu YQ, Wang M, Zheng MX, Li T, Shen YD, Jiang S, Xu JG, Gu YD, Tsien J, Xu WD. Enhancement of Contralesional Motor Control Promotes Locomotor Recovery after Unilateral Brain Lesion. Scientific Reports. 6: 18784. PMID 26732072 DOI: 10.1038/srep18784  0.52
2015 Tsien JZ. Principles of Intelligence: On Evolutionary Logic of the Brain. Frontiers in Systems Neuroscience. 9: 186. PMID 26869892 DOI: 10.3389/fnsys.2015.00186  1
2015 Tsien JZ. A Postulate on the Brain's Basic Wiring Logic. Trends in Neurosciences. 38: 669-71. PMID 26482260 DOI: 10.1016/j.tins.2015.09.002  1
2015 Li M, Zhao F, Lee J, Wang D, Kuang H, Tsien JZ. Computational Classification Approach to Profile Neuron Subtypes from Brain Activity Mapping Data. Scientific Reports. 5: 12474. PMID 26212360 DOI: 10.1038/srep12474  1
2015 Jacobs S, Wei W, Wang D, Tsien JZ. Importance of the GluN2B carboxy-terminal domain for enhancement of social memories. Learning & Memory (Cold Spring Harbor, N.Y.). 22: 401-10. PMID 26179233 DOI: 10.1101/lm.038521.115  1
2015 Zhao F, Li M, Tsien JZ. Technology platforms for remote monitoring of vital signs in the new era of telemedicine. Expert Review of Medical Devices. 12: 411-29. PMID 26037691 DOI: 10.1586/17434440.2015.1050957  1
2015 Chen H, Liu T, Zhao Y, Zhang T, Li Y, Li M, Zhang H, Kuang H, Guo L, Tsien JZ, Liu T. Optimization of large-scale mouse brain connectome via joint evaluation of DTI and neuron tracing data. Neuroimage. 115: 202-13. PMID 25953631 DOI: 10.1016/j.neuroimage.2015.04.050  1
2015 Chen H, Liu T, Zhao Y, Zhang T, Li Y, Li M, Zhang H, Kuang H, Guo L, Tsien JZ. Optimization of large-scale mouse brain connectome via joint evaluation of DTI and neuron tracing data Neuroimage. 115: 202-213. DOI: 10.1016/j.neuroimage.2015.04.050  1
2014 Jacobs S, Cui Z, Feng R, Wang H, Wang D, Tsien JZ. Molecular and genetic determinants of the NMDA receptor for superior learning and memory functions. Plos One. 9: e111865. PMID 25360708 DOI: 10.1371/journal.pone.0111865  1
2014 Chen H, Zhao Y, Zhang T, Zhang H, Kuang H, Li M, Tsien JZ, Liu T. Construct and assess multimodal mouse brain connectomes via joint modeling of multi-scale DTI and neuron tracer data. Medical Image Computing and Computer-Assisted Intervention : Miccai ... International Conference On Medical Image Computing and Computer-Assisted Intervention. 17: 273-80. PMID 25320809 DOI: 10.1007/978-3-319-10443-0_35  1
2014 Wang D, Jacobs SA, Tsien JZ. Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline. Expert Opinion On Therapeutic Targets. 18: 1121-30. PMID 25152202 DOI: 10.1517/14728222.2014.941286  1
2014 Jacobs SA, Tsien JZ. Overexpression of the NR2A subunit in the forebrain impairs long-term social recognition and non-social olfactory memory. Genes, Brain, and Behavior. 13: 376-84. PMID 24834524 DOI: 10.1111/gbb.12123  1
2014 Liu J, Wei W, Kuang H, Tsien JZ, Zhao F. Heart rate and heart rate variability assessment identifies individual differences in fear response magnitudes to earthquake, free fall, and air puff in mice. Plos One. 9: e93270. PMID 24667366 DOI: 10.1371/journal.pone.0093270  1
2014 Lian Z, Li X, Zhang H, Kuang H, Xie K, Xing J, Zhu D, Tsien JZ, Liu T, Zhang J. Detecting cell assembly interaction patterns via Bayesian based change-point detection and graph inference model 2014 Ieee 11th International Symposium On Biomedical Imaging, Isbi 2014. 17-20.  1
2013 Zhang H, Chen G, Kuang H, Tsien JZ. Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus. Plos One. 8: e79454. PMID 24302990 DOI: 10.1371/journal.pone.0079454  1
2013 Zhao F, Li M, Qian Y, Tsien JZ. Remote measurements of heart and respiration rates for telemedicine. Plos One. 8: e71384. PMID 24115996 DOI: 10.1371/journal.pone.0071384  1
2013 Tsien J. Revealing the mystery. Interview by Kristie Nybo. Biotechniques. 54: 299. PMID 23905167 DOI: 10.2144/000114036  1
2013 Tsien JZ, Li M, Osan R, Chen G, Lin L, Wang PL, Frey S, Frey J, Zhu D, Liu T, Zhao F, Kuang H. On brain activity mapping: insights and lessons from Brain Decoding Project to map memory patterns in the hippocampus. Science China. Life Sciences. 56: 767-79. PMID 23900568 DOI: 10.1007/s11427-013-4521-1  1
2013 Tsien JZ, Li M, Osan R, Chen G, Lin L, Wang PL, Frey S, Frey J, Zhu D, Liu T, Zhao F, Kuang H. On initial Brain Activity Mapping of episodic and semantic memory code in the hippocampus. Neurobiology of Learning and Memory. 105: 200-10. PMID 23838072 DOI: 10.1016/j.nlm.2013.06.019  1
2013 Xie K, Kuang H, Tsien JZ. Mild blast events alter anxiety, memory, and neural activity patterns in the anterior cingulate cortex. Plos One. 8: e64907. PMID 23741416 DOI: 10.1371/journal.pone.0064907  1
2013 Liu J, Wei W, Kuang H, Zhao F, Tsien JZ. Changes in heart rate variability are associated with expression of short-term and long-term contextual and cued fear memories. Plos One. 8: e63590. PMID 23667644 DOI: 10.1371/journal.pone.0063590  1
2013 Cui Z, Feng R, Jacobs S, Duan Y, Wang H, Cao X, Tsien JZ. Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory. Scientific Reports. 3: 1036. PMID 23301157 DOI: 10.1038/srep01036  1
2012 Zhu X, Li M, Li X, Yang Z, Tsien JZ. Robust action recognition using multi-scale spatial-temporal concatenations of local features as natural action structures. Plos One. 7: e46686. PMID 23056403 DOI: 10.1371/journal.pone.0046686  1
2012 Jacobs SA, Tsien JZ. genetic overexpression of NR2B subunit enhances social recognition memory for different strains and species. Plos One. 7: e36387. PMID 22558458 DOI: 10.1371/journal.pone.0036387  1
2012 Tsien JZ. Learning and Memory Basic Neurochemistry. 963-981. DOI: 10.1016/B978-0-12-374947-5.00056-0  1
2011 Wang LP, Li F, Wang D, Xie K, Wang D, Shen X, Tsien JZ. NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron. 72: 1055-66. PMID 22196339 DOI: 10.1016/j.neuron.2011.10.019  1
2011 Cui Y, Jin J, Zhang X, Xu H, Yang L, Du D, Zeng Q, Tsien JZ, Yu H, Cao X. Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice. Plos One. 6: e20312. PMID 21655294 DOI: 10.1371/journal.pone.0020312  1
2011 He X, Yang Z, Tsien JZ. A hierarchical probabilistic model for rapid object categorization in natural scenes. Plos One. 6: e20002. PMID 21647443 DOI: 10.1371/journal.pone.0020002  1
2011 Mei B, Li F, Gu Y, Cui Z, Tsien JZ. NMDA receptors are not required for pattern completion during associative memory recall. Plos One. 6: e19326. PMID 21559402 DOI: 10.1371/journal.pone.0019326  1
2011 Wang DV, Tsien JZ. Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations. Plos One. 6: e17047. PMID 21347237 DOI: 10.1371/journal.pone.0017047  1
2011 OÅŸan R, Chen G, Feng R, Tsien JZ. Differential consolidation and pattern reverberations within episodic cell assemblies in the mouse hippocampus. Plos One. 6: e16507. PMID 21347227 DOI: 10.1371/journal.pone.0016507  1
2011 Wang DV, Tsien JZ. Conjunctive processing of locomotor signals by the ventral tegmental area neuronal population. Plos One. 6: e16528. PMID 21304590 DOI: 10.1371/journal.pone.0016528  1
2011 Kuang H, Tsien JZ. Large-scale neural ensembles in mice: Methods for recording and data analysis Neuromethods. 54: 103-126. DOI: 10.1007/978-1-60327-202-5_5  1
2010 Xu J, Yang Z, Tsien JZ. Emergence of visual saliency from natural scenes via context-mediated probability distributions coding. Plos One. 5: e15796. PMID 21209963 DOI: 10.1371/journal.pone.0015796  1
2010 Kuang H, Lin L, Tsien JZ. Temporal dynamics of distinct CA1 cell populations during unconscious state induced by ketamine. Plos One. 5: e15209. PMID 21165147 DOI: 10.1371/journal.pone.0015209  1
2010 Bibb JA, Mayford MR, Tsien JZ, Alberini CM. Cognition enhancement strategies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14987-92. PMID 21068302 DOI: 10.1523/JNEUROSCI.4419-10.2010  1
2010 Li F, Wang LP, Shen X, Tsien JZ. Balanced dopamine is critical for pattern completion during associative memory recall. Plos One. 5: e15401. PMID 21060884 DOI: 10.1371/journal.pone.0015401  1
2010 Kuang H, Mei B, Cui Z, Lin L, Tsien JZ. A novel behavioral paradigm for assessing the concept of nests in mice. Journal of Neuroscience Methods. 189: 169-75. PMID 20350568 DOI: 10.1016/j.jneumeth.2010.03.025  1
2010 Wang LP, Li F, Shen X, Tsien JZ. Conditional knockout of NMDA receptors in dopamine neurons prevents nicotine-conditioned place preference. Plos One. 5: e8616. PMID 20062537 DOI: 10.1371/journal.pone.0008616  1
2010 Tsien JZ. Memory: Genetic Approaches Encyclopedia of Neuroscience. 779-788. DOI: 10.1016/B978-008045046-9.00766-X  1
2009 Chen G, Wang LP, Tsien JZ. Neural population-level memory traces in the mouse hippocampus. Plos One. 4: e8256. PMID 20016843 DOI: 10.1371/journal.pone.0008256  1
2009 Wang D, Cui Z, Zeng Q, Kuang H, Wang LP, Tsien JZ, Cao X. Genetic enhancement of memory and long-term potentiation but not CA1 long-term depression in NR2B transgenic rats. Plos One. 4: e7486. PMID 19838302 DOI: 10.1371/journal.pone.0007486  1
2009 Li F, Tsien JZ. Memory and the NMDA receptors. The New England Journal of Medicine. 361: 302-3. PMID 19605837 DOI: 10.1056/NEJMcibr0902052  1
2009 KUANG H, WANG PL, TSIEN JZ. Towards transgenic primates: What can we learn from mouse genetics? Science in China. Series C, Life Sciences / Chinese Academy of Sciences. 52: 506-14. PMID 19557327 DOI: 10.1007/s11427-009-0082-8  1
2009 Zhao X, Strong R, Zhang J, Sun G, Tsien JZ, Cui Z, Grotta JC, Aronowski J. Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6186-95. PMID 19439596 DOI: 10.1523/JNEUROSCI.5857-08.2009  1
2009 Heng MY, Detloff PJ, Wang PL, Tsien JZ, Albin RL. In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3200-5. PMID 19279257 DOI: 10.1523/JNEUROSCI.5599-08.2009  1
2008 Cao X, Wang H, Mei B, An S, Yin L, Wang LP, Tsien JZ. Inducible and selective erasure of memories in the mouse brain via chemical-genetic manipulation. Neuron. 60: 353-66. PMID 18957226 DOI: 10.1016/j.neuron.2008.08.027  1
2008 Wang H, Feng R, Phillip Wang L, Li F, Cao X, Tsien JZ. CaMKII activation state underlies synaptic labile phase of LTP and short-term memory formation. Current Biology : Cb. 18: 1546-54. PMID 18929487 DOI: 10.1016/j.cub.2008.08.064  1
2008 Ohtsuka N, Tansky MF, Kuang H, Kourrich S, Thomas MJ, Rubenstein JL, Ekker M, Leeman SE, Tsien JZ. Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 12961-6. PMID 18728179 DOI: 10.1073/pnas.0806180105  1
2008 Sun Q, Dong J, Yang W, Jin Y, Yang M, Wang Y, Wang PL, Hu Y, Tsien JZ. Efficient reproduction of cynomolgus monkey using pronuclear embryo transfer technique. Proceedings of the National Academy of Sciences of the United States of America. 105: 12956-60. PMID 18725640 DOI: 10.1073/pnas.0805639105  1
2008 Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2970-5. PMID 18354001 DOI: 10.1523/JNEUROSCI.5255-07.2008  1
2008 Wu P, Shen Q, Dong S, Xu Z, Tsien JZ, Hu Y. Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice. Neurobiology of Aging. 29: 1502-11. PMID 17499883 DOI: 10.1016/j.neurobiolaging.2007.03.028  1
2008 Tsien JZ. Chapter 4.1 Neural coding of episodic memory Handbook of Behavioral Neuroscience. 18: 399-416,620-625. DOI: 10.1016/S1569-7339(08)00222-1  1
2007 Tsien JZ. Real-time neural coding of memory. Progress in Brain Research. 165: 105-22. PMID 17925242 DOI: 10.1016/S0079-6123(06)65007-3  1
2007 Cho MH, Cao X, Wang D, Tsien JZ. Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Proceedings of the National Academy of Sciences of the United States of America. 104: 16317-22. PMID 17913888 DOI: 10.1073/pnas.0703344104  1
2007 Tsien JZ. The memory code. Researchers are closing in on the rules that the brain uses to lay down memories. Discovery of this memory code could lead to the design of smarter computers and robots and even to new ways to peer into the human mind. Scientific American. 297: 52-9. PMID 17695842  1
2007 Dong S, Li C, Wu P, Tsien JZ, Hu Y. Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. The European Journal of Neuroscience. 26: 101-12. PMID 17614943 DOI: 10.1111/j.1460-9568.2007.05641.x  1
2007 O?an R, Zhu L, Shoham S, Tsien JZ. Subspace projection approaches to classification and visualization of neural network-level encoding patterns. Plos One. 2: e404. PMID 17476326 DOI: 10.1371/journal.pone.0000404  1
2007 Cao X, Cui Z, Feng R, Tang YP, Qin Z, Mei B, Tsien JZ. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. The European Journal of Neuroscience. 25: 1815-22. PMID 17432968 DOI: 10.1111/j.1460-9568.2007.05431.x  1
2007 Lin L, Chen G, Kuang H, Wang D, Tsien JZ. Neural encoding of the concept of nest in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America. 104: 6066-71. PMID 17389405 DOI: 10.1073/pnas.0701106104  1
2007 Guo SB, Wang Y, Yan X, Lin L, Tsien J, Huang DS. Long-range temporal correlations in the spontaneous in vivo activity of interneuron in the mouse hippocampus Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 4682: 1339-1344.  1
2006 Wang H, Hu Y, Tsien JZ. Molecular and systems mechanisms of memory consolidation and storage. Progress in Neurobiology. 79: 123-35. PMID 16891050 DOI: 10.1016/j.pneurobio.2006.06.004  1
2006 Wei F, Wang GD, Zhang C, Shokat KM, Wang H, Tsien JZ, Liauw J, Zhuo M. Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia. Molecular Pain. 2: 21. PMID 16776832 DOI: 10.1186/1744-8069-2-21  0.84
2006 Lin L, Chen G, Xie K, Zaia KA, Zhang S, Tsien JZ. Large-scale neural ensemble recording in the brains of freely behaving mice. Journal of Neuroscience Methods. 155: 28-38. PMID 16554093 DOI: 10.1016/j.jneumeth.2005.12.032  1
2006 Lin L, Osan R, Tsien JZ. Organizing principles of real-time memory encoding: neural clique assemblies and universal neural codes. Trends in Neurosciences. 29: 48-57. PMID 16325278 DOI: 10.1016/j.tins.2005.11.004  1
2005 Cui Z, Lindl KA, Mei B, Zhang S, Tsien JZ. Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout. The European Journal of Neuroscience. 22: 755-63. PMID 16101757 DOI: 10.1111/j.1460-9568.2005.04257.x  1
2005 Lin L, Osan R, Shoham S, Jin W, Zuo W, Tsien JZ. Identification of network-level coding units for real-time representation of episodic experiences in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 102: 6125-30. PMID 15833817 DOI: 10.1073/pnas.0408233102  1
2005 Boyle MP, Brewer JA, Funatsu M, Wozniak DF, Tsien JZ, Izumi Y, Muglia LJ. Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proceedings of the National Academy of Sciences of the United States of America. 102: 473-8. PMID 15623560 DOI: 10.1073/pnas.0406458102  1
2004 Feng R, Wang H, Wang J, Shrom D, Zeng X, Tsien JZ. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proceedings of the National Academy of Sciences of the United States of America. 101: 8162-7. PMID 15148382 DOI: 10.1073/pnas.0402733101  1
2004 Cui Z, Wang H, Tan Y, Zaia KA, Zhang S, Tsien JZ. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron. 41: 781-93. PMID 15003177 DOI: 10.1016/S0896-6273(04)00072-8  1
2003 Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proceedings of the National Academy of Sciences of the United States of America. 100: 4287-92. PMID 12646704 DOI: 10.1073/pnas.0636870100  0.84
2002 Wittenberg GM, Sullivan MR, Tsien JZ. Synaptic reentry reinforcement based network model for long-term memory consolidation. Hippocampus. 12: 637-47. PMID 12440578 DOI: 10.1002/hipo.10102  1
2002 Wittenberg GM, Tsien JZ. An emerging molecular and cellular framework for memory processing by the hippocampus. Trends in Neurosciences. 25: 501-5. PMID 12220877 DOI: 10.1016/S0166-2236(02)02231-2  1
2002 Zhang J, Zhang D, McQuade JS, Behbehani M, Tsien JZ, Xu M. c-fos regulates neuronal excitability and survival. Nature Genetics. 30: 416-20. PMID 11925568 DOI: 10.1038/ng859  1
2001 Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, Sopher B, Miller MW, Ware CB, Martin GM, Kim SH, Langdon RB, Sisodia SS, Tsien JZ. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron. 32: 911-26. PMID 11738035 DOI: 10.1016/S0896-6273(01)00523-2  1
2001 Tang YP, Wang H, Feng R, Kyin M, Tsien JZ. Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology. 41: 779-90. PMID 11640933 DOI: 10.1016/S0028-3908(01)00122-8  1
2001 Philpot BD, Weisberg MP, Ramos MS, Sawtell NB, Tang YP, Tsien JZ, Bear MF. Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex. Neuropharmacology. 41: 762-70. PMID 11640931 DOI: 10.1016/S0028-3908(01)00136-8  1
2001 Mody M, Cao Y, Cui Z, Tay KY, Shyong A, Shimizu E, Pham K, Schultz P, Welsh D, Tsien JZ. Genome-wide gene expression profiles of the developing mouse hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 98: 8862-7. PMID 11438693 DOI: 10.1073/pnas.141244998  1
2001 Tang Y, Shimizu E, Tsien JZ. Do 'smart' mice feel more pain, or are they just better learners? Nature Neuroscience. 4: 453-4. PMID 11319546 DOI: 10.1038/87394  1
2001 Jiang CH, Tsien JZ, Schultz PG, Hu Y. The effects of aging on gene expression in the hypothalamus and cortex of mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 1930-4. PMID 11172053 DOI: 10.1073/pnas.98.4.1930  1
2000 Rampon C, Tsien JZ. Genetic analysis of learning behavior-induced structural plasticity. Hippocampus. 10: 605-9. PMID 11075831 DOI: 10.1002/1098-1063(2000)10:5<605::AID-HIPO11>3.0.CO;2-3  1
2000 Shimizu E, Tang YP, Rampon C, Tsien JZ. NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science (New York, N.Y.). 290: 1170-4. PMID 11073458 DOI: 10.1126/science.290.5494.1170  1
2000 Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y. Effects of environmental enrichment on gene expression in the brain. Proceedings of the National Academy of Sciences of the United States of America. 97: 12880-4. PMID 11070096 DOI: 10.1073/pnas.97.23.12880  1
2000 Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 407: 395-401. PMID 11014197 DOI: 10.1038/35030148  1
2000 Tsien JZ. Building a brainier mouse. Scientific American. 282: 62-8. PMID 10789248  1
2000 Tsien JZ. Linking Hebb's coincidence-detection to memory formation. Current Opinion in Neurobiology. 10: 266-73. PMID 10753792 DOI: 10.1016/S0959-4388(00)00070-2  1
2000 Rampon C, Tang YP, Goodhouse J, Shimizu E, Kyin M, Tsien JZ. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nature Neuroscience. 3: 238-44. PMID 10700255 DOI: 10.1038/72945  1
1999 Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ. Genetic enhancement of learning and memory in mice. Nature. 401: 63-9. PMID 10485705 DOI: 10.1038/43432  1
1999 Liu Y, Bishop A, Witucki L, Kraybill B, Shimizu E, Tsien J, Ubersax J, Blethrow J, Morgan DO, Shokat KM. Structural basis for selective inhibition of Src family kinases by PP1. Chemistry & Biology. 6: 671-8. PMID 10467133 DOI: 10.1016/S1074-5521(99)80118-5  1
1999 Tsien JZ. Chapter 3.1.3 Brain region-specific and temporally restricted gene knockout using the Cre recombinase system Techniques in the Behavioral and Neural Sciences. 13: 282-290. DOI: 10.1016/S0921-0709(99)80025-X  1
1998 Tsien JZ. Behavioral genetics: subregion- and cell type-restricted gene knockout in mouse brain. Pathologie-Biologie. 46: 699-700. PMID 9885822  1
1996 Tonegawa S, Tsien JZ, McHugh TJ, Huerta P, Blum KI, Wilson MA. Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning. Cold Spring Harbor Symposia On Quantitative Biology. 61: 225-38. PMID 9246451  1
1996 McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, Wilson MA. Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell. 87: 1339-49. PMID 8980239 DOI: 10.1016/S0092-8674(00)81828-0  1
1996 Tsien JZ, Huerta PT, Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 87: 1327-38. PMID 8980238 DOI: 10.1016/S0092-8674(00)81827-9  1
1996 Tsien JZ, Chen DF, Gerber D, Tom C, Mercer EH, Anderson DJ, Mayford M, Kandel ER, Tonegawa S. Subregion- and cell type-restricted gene knockout in mouse brain. Cell. 87: 1317-26. PMID 8980237 DOI: 10.1016/S0092-8674(00)81826-7  1
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