Dongsheng Cai, M.D., Ph.D. - Publications

Affiliations: 
Molecular Pharmacology Albert Einstein College of Medicine, USA 
Area:
NF-kB IN HYPOTHALAMIC DYSREGULATION OF ENERGY BALANCE, Aging
Website:
http://www.einstein.yu.edu/cailab/page.aspx?ekmensel=15074e5e_3468_3469_btnlink

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cai D, Khor S. "Hypothalamic Microinflammation" Paradigm in Aging and Metabolic Diseases. Cell Metabolism. 30: 19-35. PMID 31269425 DOI: 10.1016/j.cmet.2019.05.021  0.32
2019 Wang Z, Khor S, Cai D. Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice. The Journal of Biological Chemistry. PMID 30709906 DOI: 10.1074/jbc.RA118.005429  0.32
2018 Zhang Y, Kim MS, Jia B, Yan J, Zuniga-Hertz JP, Han C, Cai D. Author Correction: Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature. PMID 29950723 DOI: 10.1038/s41586-018-0303-z  0.6
2018 Li B, Wu X, Chen H, Zhuang C, Zhang Z, Yao S, Cai D, Ning G, Su Q. miR199a-5p inhibits hepatic insulin sensitivity via suppression of ATG14-mediated autophagy. Cell Death & Disease. 9: 405. PMID 29540751 DOI: 10.1038/s41419-018-0439-7  0.4
2017 Zhang Y, Kim MS, Jia B, Yan J, Zuniga-Hertz JP, Han C, Cai D. Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature. PMID 28746310 DOI: 10.1038/nature23282  0.6
2017 Zhang Y, Reichel JM, Han C, Zuniga-Hertz JP, Cai D. Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight. Cell Metabolism. 25: 1091-1102.e4. PMID 28467927 DOI: 10.1016/j.cmet.2017.04.002  0.56
2017 Khor S, Cai D. Hypothalamic and inflammatory basis of hypertension. Clinical Science (London, England : 1979). 131: 211-223. PMID 28057892 DOI: 10.1042/CS20160001  0.32
2016 Ale A, Zhang Y, Han C, Cai D. Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00337.2016. PMID 27894066 DOI: 10.1152/ajpendo.00337.2016  0.56
2016 Han C, Wu W, Ale A, Kim MS, Cai D. Central leptin and TNFα in diurnal control of blood pressure and hypertension. The Journal of Biological Chemistry. PMID 27226618 DOI: 10.1074/jbc.M116.730408  0.56
2016 Han C, Rice MW, Cai D. Neuroinflammatory and autonomic mechanisms in diabetes and hypertension. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00012.2016. PMID 27166279 DOI: 10.1152/ajpendo.00012.2016  0.56
2016 Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D. Correction: Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance Regulation. Plos Biology. 14: e1002428. PMID 27015270 DOI: 10.1371/journal.pbio.1002428  0.56
2016 Zhang Z, Li B, Meng X, Yao S, Jin L, Yang J, Wang J, Zhang H, Zhang Z, Cai D, Zhang Y, Ning G. Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress. Scientific Reports. 6: 20848. PMID 26857750 DOI: 10.1038/srep20848  0.36
2015 Song T, Zheng YM, Vincent PA, Cai D, Rosenberg P, Wang YX. Canonical transient receptor potential3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26373801 DOI: 10.1096/fj.15-274860  0.36
2015 Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nature Immunology. 16: 525-33. PMID 25848866 DOI: 10.1038/ni.3133  1
2015 Zhang Y, Liu G, Yan J, Zhang Y, Li B, Cai D. Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis. Nature Communications. 6: 6704. PMID 25848677 DOI: 10.1038/ncomms7704  1
2015 Tang Y, Purkayastha S, Cai D. Hypothalamic microinflammation: a common basis of metabolic syndrome and aging. Trends in Neurosciences. 38: 36-44. PMID 25458920 DOI: 10.1016/j.tins.2014.10.002  1
2014 Li B, Zhang Z, Zhang H, Quan K, Lu Y, Cai D, Ning G. Aberrant miR199a-5p/caveolin1/PPARα axis in hepatic steatosis. Journal of Molecular Endocrinology. 53: 393-403. PMID 25312970 DOI: 10.1530/JME-14-0127  1
2014 Shin JI, Cai D. Hypertension in obesity: the role of hypothalamic inflammation. Nature Reviews. Endocrinology. 10: 760. PMID 25311394 DOI: 10.1038/nrendo.2014.44-c1  1
2014 Yan J, Zhang H, Yin Y, Li J, Tang Y, Purkayastha S, Li L, Cai D. Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response. Nature Medicine. 20: 1001-8. PMID 25086906 DOI: 10.1038/nm.3616  1
2014 Lu Y, Liu X, Jiao Y, Xiong X, Wang E, Wang X, Zhang Z, Zhang H, Pan L, Guan Y, Cai D, Ning G, Li X. Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα. The Journal of Clinical Investigation. 124: 3501-13. PMID 25003192 DOI: 10.1172/JCI74438  1
2014 Li J, Tang Y, Purkayastha S, Yan J, Cai D. Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus. Molecular Metabolism. 3: 313-24. PMID 24749061 DOI: 10.1016/j.molmet.2014.01.012  1
2013 Purkayastha S, Cai D. Neuroinflammatory basis of metabolic syndrome. Molecular Metabolism. 2: 356-63. PMID 24327952 DOI: 10.1016/j.molmet.2013.09.005  1
2013 King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC. Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. Plos One. 8: e77452. PMID 24204831 DOI: 10.1371/journal.pone.0077452  1
2013 Cai D, Purkayastha S. A New Horizon: Oxytocin as a Novel Therapeutic Option for Obesity and Diabetes. Drug Discovery Today. Disease Mechanisms. 10: e63-e68. PMID 24159336 DOI: 10.1016/j.ddmec.2013.05.006  1
2013 Purkayastha S, Cai D. Disruption of neurogenesis by hypothalamic inflammation in obesity or aging. Reviews in Endocrine & Metabolic Disorders. 14: 351-6. PMID 24158306 DOI: 10.1007/s11154-013-9279-z  1
2013 Cai D. Central mechanisms of obesity and related metabolic diseases. Reviews in Endocrine & Metabolic Disorders. 14: 309-10. PMID 24142361 DOI: 10.1007/s11154-013-9278-0  1
2013 Tang Y, Cai D. Hypothalamic inflammation and GnRH in aging development. Cell Cycle (Georgetown, Tex.). 12: 2711-2. PMID 23966154 DOI: 10.4161/cc.26054  1
2013 Zhang H, Wu C, Chen Q, Chen X, Xu Z, Wu J, Cai D. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. Plos One. 8: e61477. PMID 23700406 DOI: 10.1371/journal.pone.0061477  1
2013 Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature. 497: 211-6. PMID 23636330 DOI: 10.1038/nature12143  1
2013 Liu T, Cai D. Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans. The Embo Journal. 32: 1529-42. PMID 23584532 DOI: 10.1038/emboj.2013.75  1
2013 Cai D. Neuroinflammation in overnutrition-induced diseases. Vitamins and Hormones. 91: 195-218. PMID 23374717 DOI: 10.1016/B978-0-12-407766-9.00008-0  1
2013 Cai D. Neuroinflammation and neurodegeneration in overnutrition-induced diseases. Trends in Endocrinology and Metabolism: Tem. 24: 40-7. PMID 23265946 DOI: 10.1016/j.tem.2012.11.003  1
2012 Li J, Tang Y, Cai D. IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nature Cell Biology. 14: 999-1012. PMID 22940906 DOI: 10.1038/ncb2562  1
2012 He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Molecular and Cellular Biology. 32: 1867-78. PMID 22431513 DOI: 10.1128/MCB.06712-11  1
2012 Cai D. One step from prediabetes to diabetes: hypothalamic inflammation? Endocrinology. 153: 1010-3. PMID 22355177 DOI: 10.1210/en.2011-2183  1
2012 Cai D, Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF-κB. Aging. 4: 98-115. PMID 22328600  1
2011 Cai D, Liu T. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Annals of the New York Academy of Sciences. 1243: E1-39. PMID 22417140 DOI: 10.1111/j.1749-6632.2011.06388.x  1
2011 Zhang G, Cai D. Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. American Journal of Physiology. Endocrinology and Metabolism. 301: E1004-12. PMID 21828335 DOI: 10.1152/ajpendo.00196.2011  1
2011 Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. Plos Biology. 9: e1001112. PMID 21814490 DOI: 10.1371/journal.pbio.1001112  1
2011 Meng Q, Cai D. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway. The Journal of Biological Chemistry. 286: 32324-32. PMID 21784844 DOI: 10.1074/jbc.M111.254417  1
2011 Purkayastha S, Zhang G, Cai D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nature Medicine. 17: 883-7. PMID 21642978 DOI: 10.1038/nm.2372  1
2011 Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q, Cai D. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 69: 523-35. PMID 21315262 DOI: 10.1016/j.neuron.2010.12.036  1
2011 Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y, Cai D. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proceedings of the National Academy of Sciences of the United States of America. 108: 2939-44. PMID 21282643 DOI: 10.1073/pnas.1006875108  1
2009 Cai D. NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system. Cell Cycle (Georgetown, Tex.). 8: 2542-8. PMID 19633416  1
2008 Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clinical and Translational Science. 1: 36-43. PMID 19337387 DOI: 10.1111/j.1752-8062.2008.00026.x  1
2008 Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 135: 61-73. PMID 18854155 DOI: 10.1016/j.cell.2008.07.043  1
2005 Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, Goodyear LJ. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. American Journal of Physiology. Cell Physiology. 289: C794-801. PMID 15888549 DOI: 10.1152/ajpcell.00632.2004  1
2005 Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nature Medicine. 11: 183-90. PMID 15685173 DOI: 10.1038/nm1166  1
2004 Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 119: 285-98. PMID 15479644 DOI: 10.1016/j.cell.2004.09.027  1
2003 Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. The Journal of Biological Chemistry. 278: 25323-30. PMID 12730241 DOI: 10.1074/jbc.M212430200  1
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