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Dongsheng Cai, M.D., Ph.D. - Publications

Affiliations: 
Molecular Pharmacology Albert Einstein College of Medicine, New York, New York, United States 
Area:
NF-kB IN HYPOTHALAMIC DYSREGULATION OF ENERGY BALANCE, Aging
Website:
http://www.einstein.yu.edu/cailab/page.aspx?ekmensel=15074e5e_3468_3469_btnlink
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yu B, Tang Y, Cai D. Brain is an endocrine organ through secretion and nuclear transfer of parathymosin. Life Science Alliance. 3. PMID 33087487 DOI: 10.26508/lsa.202000917  0.386
2020 Zhang Y, Guan Y, Pan S, Yan L, Wang P, Chen Z, Shen Q, Zhao F, Zhang X, Li J, Li J, Cai D, Zhang G. Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders. Proceedings of the National Academy of Sciences of the United States of America. PMID 32747560 DOI: 10.1073/Pnas.2004392117  0.383
2020 Shen Q, Chen Z, Zhao F, Pan S, Zhang T, Cheng X, Zhang L, Zhang S, Qi J, Li J, Cai D, Zhang G. Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1. Nature Neuroscience. PMID 32451485 DOI: 10.1038/S41593-020-0642-6  0.376
2020 Tang Y, Zuniga-Hertz JP, Han C, Yu B, Cai D. Multifaceted secretion of htNSC-derived hypothalamic islets induces survival and antidiabetic effect via peripheral implantation in mice. Elife. 9. PMID 32081132 DOI: 10.7554/Elife.52580  0.505
2020 Wang Z, Khor S, Cai D. Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action. Molecular Metabolism. 32: 56-68. PMID 32029230 DOI: 10.1016/J.Molmet.2019.12.001  0.379
2020 Xiao YZ, Yang M, Xiao Y, Guo Q, Huang Y, Li CJ, Cai D, Luo XH. Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline. Cell Metabolism. PMID 32004475 DOI: 10.1016/J.Cmet.2020.01.002  0.339
2019 Cai D, Khor S. "Hypothalamic Microinflammation" Paradigm in Aging and Metabolic Diseases. Cell Metabolism. 30: 19-35. PMID 31269425 DOI: 10.1016/J.Cmet.2019.05.021  0.363
2019 Wang Z, Khor S, Cai D. Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice. The Journal of Biological Chemistry. PMID 30709906 DOI: 10.1074/Jbc.Ra118.005429  0.482
2017 Zhang Y, Reichel JM, Han C, Zuniga-Hertz JP, Cai D. Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight. Cell Metabolism. 25: 1091-1102.e4. PMID 28467927 DOI: 10.1016/J.Cmet.2017.04.002  0.36
2016 Ale A, Zhang Y, Han C, Cai D. Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00337.2016. PMID 27894066 DOI: 10.1152/Ajpendo.00337.2016  0.373
2016 Han C, Wu W, Ale A, Kim MS, Cai D. Central leptin and TNFα in diurnal control of blood pressure and hypertension. The Journal of Biological Chemistry. PMID 27226618 DOI: 10.1074/Jbc.M116.730408  0.343
2016 Han C, Rice MW, Cai D. Neuroinflammatory and autonomic mechanisms in diabetes and hypertension. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00012.2016. PMID 27166279 DOI: 10.1152/Ajpendo.00012.2016  0.426
2015 Tang Y, Purkayastha S, Cai D. Hypothalamic microinflammation: a common basis of metabolic syndrome and aging. Trends in Neurosciences. 38: 36-44. PMID 25458920 DOI: 10.1016/J.Tins.2014.10.002  0.619
2014 Yan J, Zhang H, Yin Y, Li J, Tang Y, Purkayastha S, Li L, Cai D. Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response. Nature Medicine. 20: 1001-8. PMID 25086906 DOI: 10.1038/Nm.3616  0.645
2014 Li J, Tang Y, Purkayastha S, Yan J, Cai D. Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus. Molecular Metabolism. 3: 313-24. PMID 24749061 DOI: 10.1016/J.Molmet.2014.01.012  0.638
2013 Purkayastha S, Cai D. Neuroinflammatory basis of metabolic syndrome. Molecular Metabolism. 2: 356-63. PMID 24327952 DOI: 10.1016/J.Molmet.2013.09.005  0.575
2013 King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC. Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. Plos One. 8: e77452. PMID 24204831 DOI: 10.1371/Journal.Pone.0077452  0.537
2013 Cai D, Purkayastha S. A New Horizon: Oxytocin as a Novel Therapeutic Option for Obesity and Diabetes. Drug Discovery Today. Disease Mechanisms. 10: e63-e68. PMID 24159336 DOI: 10.1016/J.Ddmec.2013.05.006  0.585
2013 Purkayastha S, Cai D. Disruption of neurogenesis by hypothalamic inflammation in obesity or aging. Reviews in Endocrine & Metabolic Disorders. 14: 351-6. PMID 24158306 DOI: 10.1007/S11154-013-9279-Z  0.581
2013 Cai D. Central mechanisms of obesity and related metabolic diseases. Reviews in Endocrine & Metabolic Disorders. 14: 309-10. PMID 24142361 DOI: 10.1007/S11154-013-9278-0  0.418
2013 Tang Y, Cai D. Hypothalamic inflammation and GnRH in aging development. Cell Cycle (Georgetown, Tex.). 12: 2711-2. PMID 23966154 DOI: 10.4161/Cc.26054  0.533
2013 Zhang H, Wu C, Chen Q, Chen X, Xu Z, Wu J, Cai D. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. Plos One. 8: e61477. PMID 23700406 DOI: 10.1371/Journal.Pone.0061477  0.44
2013 Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature. 497: 211-6. PMID 23636330 DOI: 10.1038/Nature12143  0.611
2012 Li J, Tang Y, Cai D. IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nature Cell Biology. 14: 999-1012. PMID 22940906 DOI: 10.1038/Ncb2562  0.546
2012 He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Molecular and Cellular Biology. 32: 1867-78. PMID 22431513 DOI: 10.1128/Mcb.06712-11  0.393
2011 Zhang G, Cai D. Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. American Journal of Physiology. Endocrinology and Metabolism. 301: E1004-12. PMID 21828335 DOI: 10.1152/Ajpendo.00196.2011  0.371
2011 Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. Plos Biology. 9: e1001112. PMID 21814490 DOI: 10.1371/Journal.Pbio.1001112  0.405
2011 Meng Q, Cai D. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway. The Journal of Biological Chemistry. 286: 32324-32. PMID 21784844 DOI: 10.1074/jbc.M111.254417  0.339
2011 Purkayastha S, Zhang G, Cai D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nature Medicine. 17: 883-7. PMID 21642978 DOI: 10.1038/Nm.2372  0.56
2011 Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q, Cai D. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 69: 523-35. PMID 21315262 DOI: 10.1016/J.Neuron.2010.12.036  0.355
2011 Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y, Cai D. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proceedings of the National Academy of Sciences of the United States of America. 108: 2939-44. PMID 21282643 DOI: 10.1073/Pnas.1006875108  0.561
2008 Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clinical and Translational Science. 1: 36-43. PMID 19337387 DOI: 10.1111/J.1752-8062.2008.00026.X  0.712
2008 Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 135: 61-73. PMID 18854155 DOI: 10.1016/J.Cell.2008.07.043  0.471
2005 Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, Goodyear LJ. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. American Journal of Physiology. Cell Physiology. 289: C794-801. PMID 15888549 DOI: 10.1152/Ajpcell.00632.2004  0.508
2005 Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nature Medicine. 11: 183-90. PMID 15685173 DOI: 10.1038/Nm1166  0.717
2004 Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 119: 285-98. PMID 15479644 DOI: 10.1016/J.Cell.2004.09.027  0.691
2003 Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. The Journal of Biological Chemistry. 278: 25323-30. PMID 12730241 DOI: 10.1074/Jbc.M212430200  0.699
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