Gen-Sheng Feng, PhD - Publications

School of Medicine University of California, San Diego, La Jolla, CA 
Signal Transduction

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Liu W, Yin Y, Wang M, Fan T, Zhu Y, Shen L, Peng S, Gao J, Deng G, Meng X, Kong L, Feng GS, Guo W, Xu Q, Sun Y. Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels. The Journal of Biological Chemistry. PMID 32546483 DOI: 10.1074/Jbc.Ra119.011840  0.329
2019 Yang BH, Wang K, Wan S, Liang Y, Yuan X, Dong Y, Cho S, Xu W, Jepsen K, Feng GS, Lu LF, Xue HH, Fu W. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Reports. 27: 3629-3645.e6. PMID 31216480 DOI: 10.1016/J.Celrep.2019.05.061  0.351
2019 Li Y, Liu WS, Yi J, Kong SB, Ding JC, Zhao YN, Tian YP, Feng GS, Li CJ, Liu W, Wang HB, Lu ZX. The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis. Asian Journal of Andrology. PMID 31210146 DOI: 10.4103/Aja.Aja_49_19  0.426
2019 Huo Y, Chen WS, Lee J, Feng GS, Newton IG. Stress Conditions Induced by Locoregional Therapies Stimulate Enrichment and Proliferation of Liver Cancer Stem Cells. Journal of Vascular and Interventional Radiology : Jvir. PMID 31208945 DOI: 10.1016/J.Jvir.2019.02.026  0.307
2019 Li H, Mao Y, Bouaziz M, Yu H, Qu X, Wang F, Feng GS, Shawber C, Zhang X. Lens differentiation is controlled by the balance between PDGF and FGF signaling. Plos Biology. 17: e3000133. PMID 30716082 DOI: 10.1371/Journal.Pbio.3000133  0.495
2018 Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. Shp2 Deletion in Hepatocytes Suppresses Hepatocarcinogenesis Driven by Oncogenic β-Catenin, PIK3CA and MET. Journal of Hepatology. PMID 29505847 DOI: 10.1016/J.Jhep.2018.02.014  0.358
2018 Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X. Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 7. PMID 29360039 DOI: 10.7554/Elife.32586  0.41
2017 Liang Y, Feng Y, Zong M, Wei X, Lee J, Feng Y, Li H, Yang G, Wu ZJ, Fu XD, Feng GS. β-Catenin Deficiency in Hepatocytes Aggravates Hepatocarcinogenesis Driven by Oncogenic β-Catenin and MET. Hepatology (Baltimore, Md.). PMID 29152756 DOI: 10.1002/Hep.29661  0.346
2017 Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng GS. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Reports. 21: 1870-1882. PMID 29141219 DOI: 10.1016/J.Celrep.2017.10.064  0.322
2017 Garg A, Bansal M, Gotoh N, Feng GS, Zhong J, Wang F, Kariminejad A, Brooks S, Zhang X. Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis. Plos Genetics. 13: e1007047. PMID 29028795 DOI: 10.1371/Journal.Pgen.1007047  0.409
2017 Cheng J, Zhong Y, Chen S, Sun Y, Huang L, Kang Y, Chen B, Chen G, Wang F, Tian Y, Liu W, Feng GS, Lu Z. Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28842424 DOI: 10.1096/Fj.201700120Rr  0.467
2017 Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28424251 DOI: 10.1073/Pnas.1700978114  0.422
2016 Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng GS. Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. Cell Reports. 17: 2979-2993. PMID 27974211 DOI: 10.1016/J.Celrep.2016.11.048  0.493
2016 Liu W, Guo W, Shen L, Chen Z, Luo Q, Luo X, Feng GS, Shu Y, Gu Y, Xu Q, Sun Y. T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget. PMID 27935860 DOI: 10.18632/Oncotarget.13812  0.359
2016 Mathew G, Hannan A, Hertzler-Schaefer K, Wang F, Feng GS, Zhong J, Zhao JJ, Downward J, Zhang X. Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799550 DOI: 10.1073/Pnas.1604450113  0.375
2016 Chen S, Kang Y, Sun Y, Zhong Y, Li Y, Deng L, Tao J, Li Y, Tian Y, Zhao Y, Cheng J, Liu W, Feng GS, Lu Z. Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease. Journal of Molecular Cell Biology. PMID 27282405 DOI: 10.1093/Jmcb/Mjw028  0.339
2016 Coulombe G, Langlois A, De Palma G, Langlois MJ, McCarville JL, Gagné-Sanfaçon J, Perreault N, Feng GS, Bercik P, Boudreau F, Verdu EF, Rivard N. SHP-2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host-Microbiota Homeostasis. Journal of Cellular Physiology. PMID 27100271 DOI: 10.1002/Jcp.25407  0.372
2016 Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proceedings of the National Academy of Sciences of the United States of America. PMID 26858399 DOI: 10.1073/Pnas.1524510113  0.311
2016 Chen WS, Zhu HH, Feng GS. Treating Leukemia at Risk of Inducing Severe Anemia. Experimental Hematology. PMID 26826310 DOI: 10.1016/J.Exphem.2016.01.004  0.538
2015 Zhu HH, Luo X, Zhang K, Cui J, Zhao H, Ji Z, Zhou Z, Yao J, Zeng L, Ji K, Gao WQ, Zhang ZY, Feng GS. Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proceedings of the National Academy of Sciences of the United States of America. PMID 26460004 DOI: 10.1073/pnas.1507599112  0.517
2015 Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Scientific Reports. 5: 12982. PMID 26265072 DOI: 10.1038/Srep12982  0.439
2015 Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, ... ... Feng GS, et al. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nature Immunology. 16: 642-52. PMID 25915733 DOI: 10.1038/Ni.3155  0.459
2015 Luo T, Fu J, Xu A, Su B, Ren Y, Li N, Zhu J, Zhao X, Dai R, Cao J, Wang B, Qin W, Jiang J, Li J, Wu M, ... Feng G, et al. PSMD10/Gankyrin Induces Autophagy to Promote Tumor Progression through Cytoplasmic Interaction with ATG7 and Nuclear Transactivation of ATG7 Expression. Autophagy. 0. PMID 25905985 DOI: 10.1080/15548627.2015.1034405  0.33
2015 Han T, Xiang DM, Sun W, Liu N, Sun HL, Wen W, Shen WF, Wang RY, Chen C, Wang X, Cheng Z, Li HY, Wu MC, Cong WM, Feng GS, et al. PTPN11/Shp2 Overexpression Enhances Liver Cancer Progression and Predicts Poor Prognosis of Patients. Journal of Hepatology. PMID 25865556 DOI: 10.1016/J.Jhep.2015.03.036  0.398
2015 Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng GS, Chan RJ. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. The Journal of Biological Chemistry. 290: 3894-909. PMID 25538234 DOI: 10.1074/Jbc.M114.614057  0.641
2015 Li S, Ni A, Feng GS. Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis. Acta Pharmacologica Sinica. 36: 113-8. PMID 25500873 DOI: 10.1038/Aps.2014.118  0.355
2015 Su B, Luo T, Zhu J, Fu J, Zhao X, Chen L, Zhang H, Ren Y, Yu L, Yang X, Wu M, Feng G, Li S, Chen Y, Wang H. Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology (Baltimore, Md.). 61: 585-97. PMID 25294684 DOI: 10.1002/Hep.27551  0.39
2014 Li J, Kang Y, Wei L, Liu W, Tian Y, Chen B, Lin X, Li Y, Feng GS, Lu Z. Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. Plos One. 9: e102847. PMID 25048202 DOI: 10.1371/Journal.Pone.0102847  0.348
2014 Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, ... Feng GS, et al. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metabolism. 20: 320-32. PMID 24981838 DOI: 10.1016/J.Cmet.2014.05.020  0.542
2014 Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPα regulates macrophage activation and systemic metabolism. American Journal of Physiology. Endocrinology and Metabolism. 306: E1144-54. PMID 24691027 DOI: 10.1152/Ajpendo.00002.2014  0.304
2014 Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X. Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development. Journal of Cell Science. 127: 571-82. PMID 24284065 DOI: 10.1242/Jcs.134478  0.409
2014 Puri P, Phillips BT, Suzuki H, Orwig KE, Rajkovic A, Lapinski PE, King PD, Feng GS, Walker WH. The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase. Stem Cells (Dayton, Ohio). 32: 741-53. PMID 24123360 DOI: 10.1002/Stem.1572  0.344
2014 Li X, Goodwin C, Yang Z, Nabinger SC, Richine B, Chan G, Hanenberg H, Ohnishi H, Matozaki T, El Benna J, Feng G, Neel B, Chan RJ. Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function Blood. 124: 1397-1397. DOI: 10.1182/Blood.V124.21.1397.1397  0.639
2013 Ng GY, Yeh LK, Zhang Y, Liu H, Feng GS, Kao WW, Liu CY. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Investigative Ophthalmology & Visual Science. 54: 7933-42. PMID 24204042 DOI: 10.1167/Iovs.13-12646  0.392
2013 Zheng L, Yang W, Wu F, Wang C, Yu L, Tang L, Qiu B, Li Y, Guo L, Wu M, Feng G, Zou D, Wang H. Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5372-80. PMID 23942093 DOI: 10.1158/1078-0432.Ccr-13-0203  0.367
2013 Wen W, Han T, Chen C, Huang L, Sun W, Wang X, Chen SZ, Xiang DM, Tang L, Cao D, Feng GS, Wu MC, Ding J, Wang HY. Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. Molecular Cancer Therapeutics. 12: 1796-804. PMID 23804702 DOI: 10.1158/1535-7163.Mct-13-0099  0.356
2013 Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F, Zhang X. Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development (Cambridge, England). 140: 2711-23. PMID 23720040 DOI: 10.1242/Dev.089987  0.348
2013 Coulombe G, Leblanc C, Cagnol S, Maloum F, Lemieux E, Perreault N, Feng GS, Boudreau F, Rivard N. Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Molecular and Cellular Biology. 33: 2275-84. PMID 23530062 DOI: 10.1128/Mcb.00043-13  0.337
2013 Chen H, Luo Z, Dong L, Tan Y, Yang J, Feng G, Wu M, Li Z, Wang H. CD133/Prominin-1-Mediated Autophagy and Glucose Uptake Beneficial for Hepatoma Cell Survival Plos One. 8. PMID 23437259 DOI: 10.1371/Journal.Pone.0056878  0.319
2013 Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America. 110: 3137-42. PMID 23382182 DOI: 10.1073/Pnas.1215501110  0.314
2013 Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. The Journal of Biological Chemistry. 288: 3823-30. PMID 23269672 DOI: 10.1074/Jbc.M112.397885  0.552
2013 He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proceedings of the National Academy of Sciences of the United States of America. 110: E79-88. PMID 23236157 DOI: 10.1073/pnas.1213000110  0.453
2013 Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Zeng L, Richine B, Bowling JD, Fukuda S, Goenka S, Liu Z, Feng GS, Yu M, Sandusky GE, Boswell HS, et al. The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo. Leukemia. 27: 398-408. PMID 23103841 DOI: 10.1038/leu.2012.308  0.612
2013 Broxmeyer HE, Etienne-Julan M, Gotoh A, Braun SE, Lu L, Cooper S, Feng GS, Li XJ, Chan RJ. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. Stem Cells and Development. 22: 998-1006. PMID 23082805 DOI: 10.1089/Scd.2012.0478  0.577
2012 Haglund E, SuÅ‚kowska JI, He Z, Feng GS, Jennings PA, Onuchic JN. The unique cysteine knot regulates the pleotropic hormone leptin. Plos One. 7: e45654. PMID 23029163 DOI: 10.1371/Journal.Pone.0045654  0.34
2012 Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology (Baltimore, Md.). 56: 2255-67. PMID 22898879 DOI: 10.1002/Hep.26007  0.364
2012 Li S, Hsu DD, Wang H, Feng GS. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis. Frontiers of Medicine. 6: 275-9. PMID 22869052 DOI: 10.1007/S11684-012-0216-4  0.355
2012 Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, ... ... Feng GS, et al. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 120: 2669-78. PMID 22806893 DOI: 10.1182/Blood-2011-08-375873  0.598
2012 Huang H, Woo AJ, Waldon Z, Schindler Y, Moran TB, Zhu HH, Feng GS, Steen H, Cantor AB. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes & Development. 26: 1587-601. PMID 22759635 DOI: 10.1101/Gad.192054.112  0.585
2012 Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nature Communications. 3: 911. PMID 22713753 DOI: 10.1038/Ncomms1919  0.35
2012 Yang W, Wang C, Lin Y, Liu Q, Yu LX, Tang L, Yan HX, Fu J, Chen Y, Zhang HL, Tang L, Zheng LY, He YQ, Li YQ, Wu FQ, ... ... Feng GS, et al. OV6⁺ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. Journal of Hepatology. 57: 613-20. PMID 22612999 DOI: 10.1016/J.Jhep.2012.04.024  0.319
2012 Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng GS, Hartmann K, Roers A, Craig AW. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Molecular and Cellular Biology. 32: 2653-63. PMID 22566685 DOI: 10.1128/Mcb.00308-12  0.366
2012 He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Molecular and Cellular Biology. 32: 1867-78. PMID 22431513 DOI: 10.1128/Mcb.06712-11  0.427
2012 Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, et al. p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology. 142: 1547-58.e14. PMID 22387393 DOI: 10.1053/J.Gastro.2012.02.042  0.319
2012 Zhang X, Zhang Y, Tao B, Teng L, Li Y, Cao R, Gui Q, Ye M, Mou X, Cheng H, Hu H, Zhou R, Wu X, Xie Q, Ning W, ... ... Feng GS, et al. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2338-50. PMID 22362894 DOI: 10.1096/Fj.11-200139  0.533
2012 Wen W, Ding J, Sun W, Fu J, Chen Y, Wu K, Ning B, Han T, Huang L, Chen C, Xie D, Li Z, Feng G, Wu M, Xie W, et al. Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression Hepatology. 55: 1787-1798. PMID 22271581 DOI: 10.1002/Hep.25596  0.343
2012 Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Richine B, Bowling J, Fukuda S, Goenka S, Liu Z, Feng G, Yu M, Sandusky G, Boswell HS, Zhang Z, et al. The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells. Blood. 120: 2420-2420. DOI: 10.1182/Blood.V120.21.2420.2420  0.646
2011 Li L, Chen L, Hu L, Liu Y, Sun HY, Tang J, Hou YJ, Chang YX, Tu QQ, Feng GS, Shen F, Wu MC, Wang HY. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology (Baltimore, Md.). 54: 1620-30. PMID 21809356 DOI: 10.1002/Hep.24552  0.392
2011 Sun W, Ding J, Wu K, Ning BF, Wen W, Sun HY, Han T, Huang L, Dong LW, Yang W, Deng X, Li Z, Wu MC, Feng GS, Xie WF, et al. Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells. Hepatology (Baltimore, Md.). 54: 1259-72. PMID 21735473 DOI: 10.1002/Hep.24530  0.386
2011 Zhu HH, Feng GS. The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. Cell Cycle (Georgetown, Tex.). 10: 2241-2. PMID 21701261 DOI: 10.4161/Cc.10.14.15861  0.402
2011 Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng GS, Corey SJ. G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Blood. 118: 1077-86. PMID 21636860 DOI: 10.1182/Blood-2009-12-261636  0.536
2011 Cai Z, Simons DL, Fu XY, Feng GS, Wu SM, Zhang X. Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration. Molecular and Cellular Biology. 31: 2973-83. PMID 21576358 DOI: 10.1128/MCB.05054-11  0.326
2011 Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng GS. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell. 19: 629-39. PMID 21575863 DOI: 10.1016/J.Ccr.2011.03.023  0.514
2011 Zhu HH, Ji K, Alderson N, He Z, Li S, Liu W, Zhang DE, Li L, Feng GS. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood. 117: 5350-61. PMID 21450902 DOI: 10.1182/Blood-2011-01-333476  0.582
2011 Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Hessling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, ... Feng GS, et al. Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proceedings of the National Academy of Sciences of the United States of America. 108: 2957-62. PMID 21282639 DOI: 10.1073/Pnas.1009395108  0.351
2011 Fu J, Chen Y, Cao J, Luo T, Qian YW, Yang W, Ren YB, Su B, Cao GW, Yang Y, Yan YQ, Shen F, Wu MC, Feng GS, Wang HY. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways. Hepatology (Baltimore, Md.). 53: 181-92. PMID 21254169 DOI: 10.1002/Hep.24015  0.343
2011 Bauler TJ, Kamiya N, Lapinski PE, Langewisch E, Mishina Y, Wilkinson JE, Feng GS, King PD. Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations. Disease Models & Mechanisms. 4: 228-39. PMID 21068439 DOI: 10.1242/Dmm.006130  0.313
2011 Ruan X, Li Z, Zhang Y, Yang L, Pan Y, Wang Z, Feng GS, Chen Y. Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat. Journal of Cellular and Molecular Medicine. 15: 763-72. PMID 20193037 DOI: 10.1111/J.1582-4934.2010.01045.X  0.3
2011 Ma P, Mali R, Zeng L, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger SC, Li S, Munugalavadla V, Chatterjee A, Sandusky G, Craig A, Bunting KD, ... Feng G, et al. KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML Blood. 118: 868-868. DOI: 10.1182/Blood.V118.21.868.868  0.646
2010 Zhu Y, Park J, Hu X, Zheng K, Li H, Cao Q, Feng GS, Qiu M. Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphatase. Glia. 58: 1407-14. PMID 20648636 DOI: 10.1002/Glia.21016  0.401
2010 Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X. Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages Journal of Immunology. 184: 6447-6456. PMID 20435932 DOI: 10.4049/Jimmunol.0901750  0.325
2010 Cai Z, Feng GS, Zhang X. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4110-9. PMID 20237281 DOI: 10.1523/Jneurosci.4364-09.2010  0.358
2010 Pan Y, Carbe C, Powers A, Feng GS, Zhang X. Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development (Cambridge, England). 137: 1085-93. PMID 20215346 DOI: 10.1242/Dev.042820  0.425
2010 Weng T, Mao F, Wang Y, Sun Q, Li R, Yang G, Zhang X, Luo J, Feng GS, Yang X. Osteoblastic molecular scaffold Gab1 is required for maintaining bone homeostasis. Journal of Cell Science. 123: 682-9. PMID 20124419 DOI: 10.1242/Jcs.058396  0.361
2010 Huang H, Waldon Z, Chan G, Zhu H, Steen H, Feng G, Neel B, Cantor A. Tyrosine Phosphorylation of Runx1 In Megakaryocytes by Src Family Kinases Blood. 116: 742-742. DOI: 10.1182/Blood.V116.21.742.742  0.591
2010 Zhu HH, Ji K, Alderson N, He Z, Li S, Li L, Feng G. Coordinated Regulation of Embryonic and Adult Hematopoietic Stem Cell Activity by PTPN11/Shp2. Blood. 116: 2630-2630. DOI: 10.1182/Blood.V116.21.2630.2630  0.542
2010 Futami M, Zhu Q, Feng G, Neel B, Corey SJ. The G-CSF Receptor Requires Gab2-Mediated Recruitment of the Tyrosine Phosphatase Shp2 to Promote Lyn-Dependent Proliferation. Blood. 116: 1555-1555. DOI: 10.1182/Blood.V116.21.1555.1555  0.416
2009 McPherson VA, Sharma N, Everingham S, Smith J, Zhu HH, Feng GS, Craig AW. SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 4940-7. PMID 19786542 DOI: 10.4049/Jimmunol.0900702  0.594
2009 Hagihara K, Zhang EE, Ke YH, Liu G, Liu JJ, Rao Y, Feng GS. Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development. Developmental Biology. 334: 276-84. PMID 19635473 DOI: 10.1016/J.Ydbio.2009.07.029  0.698
2009 Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 7531-6. PMID 19380737 DOI: 10.1073/Pnas.0811715106  0.344
2009 Wu D, Pang Y, Ke Y, Yu J, He Z, Tautz L, Mustelin T, Ding S, Huang Z, Feng GS. A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. Plos One. 4: e4914. PMID 19290061 DOI: 10.1371/Journal.Pone.0004914  0.613
2009 Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T. PTEN regulation by Akt-EGR1-ARF-PTEN axis. The Embo Journal. 28: 21-33. PMID 19057511 DOI: 10.1038/Emboj.2008.238  0.587
2009 Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, ... Feng GS, et al. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Molecular and Cellular Biology. 29: 378-88. PMID 19001090 DOI: 10.1128/Mcb.01661-08  0.358
2009 Nabinger SC, He Y, Yin F, Zhang X, Senbanjo L, Fukuda S, Yu M, Feng G, Zhang Z, Kapur R, Chan RJ. Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors. Blood. 114: 827-827. DOI: 10.1182/Blood.V114.22.827.827  0.627
2008 Mitra S, Beach C, Feng GS, Plattner R. SHP-2 is a novel target of Abl kinases during cell proliferation. Journal of Cell Science. 121: 3335-46. PMID 18827006 DOI: 10.1242/Jcs.035691  0.437
2008 Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, ... ... Feng GS, et al. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity. Journal of Medicinal Chemistry. 51: 5650-62. PMID 18759424 DOI: 10.1021/Jm800456K  0.389
2008 Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, Chen Y. Characterization of the topology and functional domains of RKTG. The Biochemical Journal. 414: 399-406. PMID 18547165 DOI: 10.1042/Bj20080948  0.345
2008 Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. The American Journal of Pathology. 172: 1312-24. PMID 18403587 DOI: 10.2353/Ajpath.2008.070594  0.555
2008 Pan Y, Carbe C, Powers A, Zhang EE, Esko JD, Grobe K, Feng GS, Zhang X. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development (Cambridge, England). 135: 301-10. PMID 18077586 DOI: 10.1242/Dev.014829  0.628
2008 Wu D, Pang Y, Ke Y, He Z, Feng G. A conserved role of Shp2 in regulation of human and mouse ES cell differentiation Cell Research. 18: S27-S27. DOI: 10.1038/Cr.2008.117  0.602
2007 Ruhul Amin AR, Uddin Biswas MH, Senga T, Feng GS, Kannagi R, Agarwal ML, Hamaguchi M. A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 12: 1023-33. PMID 17825046 DOI: 10.1111/J.1365-2443.2007.01115.X  0.448
2007 Ke Y, Zhang EE, Hagihara K, Wu D, Pang Y, Klein R, Curran T, Ranscht B, Feng GS. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Molecular and Cellular Biology. 27: 6706-17. PMID 17646384 DOI: 10.1128/Mcb.01225-07  0.713
2007 Ni S, Zhao C, Feng GS, Paulson RF, Correll PH. A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection. Molecular and Cellular Biology. 27: 3708-15. PMID 17353274 DOI: 10.1128/Mcb.01838-06  0.548
2007 Ke Y, Wu D, Princen F, Nguyen T, Pang Y, Lesperance J, Muller WJ, Oshima RG, Feng GS. Role of Gab2 in mammary tumorigenesis and metastasis. Oncogene. 26: 4951-60. PMID 17310989 DOI: 10.1038/sj.onc.1210315  0.502
2007 Feng GS. Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. Cell Research. 17: 37-41. PMID 17211446 DOI: 10.1038/Sj.Cr.7310140  0.421
2007 Chan RJ, Feng GS. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood. 109: 862-7. PMID 17053061 DOI: 10.1182/Blood-2006-07-028829  0.565
2006 An H, Zhao W, Hou J, Zhang Y, Xie Y, Zheng Y, Xu H, Qian C, Zhou J, Yu Y, Liu S, Feng G, Cao X. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity. 25: 919-28. PMID 17157040 DOI: 10.1016/J.Immuni.2006.10.014  0.414
2006 Nguyen TV, Ke Y, Zhang EE, Feng GS. Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. Journal of Immunology (Baltimore, Md. : 1950). 177: 5990-6. PMID 17056523 DOI: 10.4049/Jimmunol.177.9.5990  0.711
2006 Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS. Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. The Journal of Biological Chemistry. 281: 34374-80. PMID 16959766 DOI: 10.1074/Jbc.M607325200  0.707
2006 Dong XP, Li XM, Gao TM, Zhang EE, Feng GS, Xiong WC, Mei L. Shp2 is dispensable in the formation and maintenance of the neuromuscular junction. Neuro-Signals. 15: 53-63. PMID 16837792 DOI: 10.1159/000094484  0.536
2006 Bard-Chapeau EA, Yuan J, Droin N, Long S, Zhang EE, Nguyen TV, Feng GS. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Molecular and Cellular Biology. 26: 4664-74. PMID 16738330 DOI: 10.1128/Mcb.02253-05  0.628
2006 Feng GS. Shp2 as a therapeutic target for leptin resistance and obesity. Expert Opinion On Therapeutic Targets. 10: 135-42. PMID 16441233 DOI: 10.1517/14728222.10.1.135  0.315
2006 Ni S, Xu J, Teal H, Feng G, Paulson RF, Correll PH. A Noval Stat3 Binding Site in Gab2 Mediates Hematopoietic Transformation by Friend Erythroleukemia Virus. Blood. 108: 465-465. DOI: 10.1182/Blood.V108.11.465.465  0.422
2005 Xu R, Yu Y, Zheng S, Zhao X, Dong Q, He Z, Liang Y, Lu Q, Fang Y, Gan X, Xu X, Zhang S, Dong Q, Zhang X, Feng GS. Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. Blood. 106: 3142-9. PMID 16030196 DOI: 10.1182/Blood-2004-10-4057  0.436
2005 Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nature Medicine. 11: 567-71. PMID 15821749 DOI: 10.1038/Nm1227  0.564
2005 Wang FM, Liu HQ, Liu SR, Tang SP, Yang L, Feng GS. SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin, dephosphorylation of FAK and secretion of MMP-9 induced by IL-1beta in vivo and in vitro. Breast Cancer Research and Treatment. 89: 5-14. PMID 15666191 DOI: 10.1007/S10549-004-1002-Z  0.38
2004 Zhang EE, Chapeau E, Hagihara K, Feng GS. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proceedings of the National Academy of Sciences of the United States of America. 101: 16064-9. PMID 15520383 DOI: 10.1073/Pnas.0405041101  0.631
2004 Ivins Zito C, Kontaridis MI, Fornaro M, Feng GS, Bennett AM. SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. Journal of Cellular Physiology. 199: 227-36. PMID 15040005 DOI: 10.1002/Jcp.10446  0.343
2004 Sun Y, Yuan J, Liu H, Shi Z, Baker K, Vuori K, Wu J, Feng GS. Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis. Molecular and Cellular Biology. 24: 1531-9. PMID 14749370 DOI: 10.1128/Mcb.24.4.1531-1539.2004  0.319
2004 Chan RJ, You M, Feng GS. Identification of trans-acting factors by electrophoretic mobility shift assay. Methods in Molecular Biology (Clifton, N.J.). 249: 7-20. PMID 14573887 DOI: 10.1385/1-59259-667-3:7  0.457
2004 Feng G. Mutated SHP and AML in leukemias Blood. 103: 1982-1983. DOI: 10.1182/Blood-2004-01-0060  0.426
2003 von Wichert G, Haimovich B, Feng GS, Sheetz MP. Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. The Embo Journal. 22: 5023-35. PMID 14517241 DOI: 10.1093/Emboj/Cdg492  0.323
2003 Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. The Journal of Biological Chemistry. 278: 34641-53. PMID 12819203 DOI: 10.1074/Jbc.M304594200  0.562
2003 Chan RJ, Johnson SA, Li Y, Yoder MC, Feng GS. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood. 102: 2074-80. PMID 12791646 DOI: 10.1182/Blood-2003-04-1171  0.629
2003 MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP. The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts. The Journal of Biological Chemistry. 278: 27190-8. PMID 12721296 DOI: 10.1074/Jbc.M213083200  0.383
2003 Chen Y, Wen R, Yang S, Schuman J, Zhang EE, Yi T, Feng GS, Wang D. Identification of Shp-2 as a Stat5A phosphatase. The Journal of Biological Chemistry. 278: 16520-7. PMID 12615921 DOI: 10.1074/Jbc.M210572200  0.644
2002 Wu TR, Hong YK, Wang XD, Ling MY, Dragoi AM, Chung AS, Campbell AG, Han ZY, Feng GS, Chin YE. SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. The Journal of Biological Chemistry. 277: 47572-80. PMID 12270932 DOI: 10.1074/Jbc.M207536200  0.465
2002 Shen R, Ouyang YB, Qu CK, Alonso A, Sperzel L, Mustelin T, Kaplan MH, Feng GS. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Molecular and Cellular Biology. 22: 3230-6. PMID 11971956  0.369
2001 Wu CJ, O'Rourke DM, Feng GS, Johnson GR, Wang Q, Greene MI. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors. Oncogene. 20: 6018-25. PMID 11593409 DOI: 10.1038/Sj.Onc.1204699  0.477
2001 Qu C, Nguyen S, Chen J, Feng G. Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development Blood. 97: 911-914. PMID 11159516 DOI: 10.1182/Blood.V97.4.911  0.387
2001 You M, Flick LM, Yu D, Feng GS. Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. The Journal of Experimental Medicine. 193: 101-10. PMID 11136824 DOI: 10.1084/Jem.193.1.101  0.541
2000 Schoenwaelder SM, Petch LA, Williamson D, Shen R, Feng GS, Burridge K. The protein tyrosine phosphatase Shp-2 regulates RhoA activity. Current Biology : Cb. 10: 1523-6. PMID 11114521 DOI: 10.1016/S0960-9822(00)00831-9  0.33
2000 Shi ZQ, Yu DH, Park M, Marshall M, Feng GS. Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity. Molecular and Cellular Biology. 20: 1526-36. PMID 10669730 DOI: 10.1128/Mcb.20.5.1526-1536.2000  0.599
1999 Feng GS. Shp-2 tyrosine phosphatase: Signaling one cell or many Experimental Cell Research. 253: 47-54. PMID 10579910 DOI: 10.1006/Excr.1999.4668  0.439
1999 Tanowitz M, Si J, Yu DH, Feng GS, Mei L. Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9426-35. PMID 10531446  0.56
1999 Kim CH, Qu CK, Hangoc G, Cooper S, Anzai N, Feng GS, Broxmeyer HE. Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. The Journal of Experimental Medicine. 190: 681-90. PMID 10477552 DOI: 10.1084/Jem.190.5.681  0.324
1999 Zhao C, Yu DH, Shen R, Feng GS. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. The Journal of Biological Chemistry. 274: 19649-54. PMID 10391903 DOI: 10.1074/Jbc.274.28.19649  0.667
1999 You M, Yu DH, Feng GS. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Molecular and Cellular Biology. 19: 2416-24. PMID 10022928 DOI: 10.1128/Mcb.19.3.2416  0.577
1998 Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM. The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene. 17: 1893-901. PMID 9788432 DOI: 10.1038/Sj.Onc.1202108  0.398
1998 Qu CK, Feng GS. Shp-2 has a positive regulatory role in ES cell differentiation and proliferation. Oncogene. 17: 433-9. PMID 9696036 DOI: 10.1038/sj.onc.1201920  0.315
1998 Yu DH, Qu CK, Henegariu O, Lu X, Feng GS. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. The Journal of Biological Chemistry. 273: 21125-31. PMID 9694867 DOI: 10.1074/jbc.273.33.21125  0.557
1998 Shi Z, Lu W, Feng G. The Shp-2 Tyrosine Phosphatase Has Opposite Effects in Mediating the Activation of Extracellular Signal-regulated and c-Jun NH2-terminal Mitogen-activated Protein Kinases Journal of Biological Chemistry. 273: 4904-4908. PMID 9478933 DOI: 10.1074/Jbc.273.9.4904  0.497
1998 Kim SO, Jiang J, Yi W, Feng GS, Frank SJ. Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling Journal of Biological Chemistry. 273: 2344-2354. PMID 9442080 DOI: 10.1074/Jbc.273.4.2344  0.485
1997 Tang J, Feng GS, Li W. Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor. Oncogene. 15: 1823-32. PMID 9362449 DOI: 10.1038/Sj.Onc.1201351  0.371
1997 Tauchi T, Miyazawa K, Feng GS, Broxmeyer HE, Toyama K. A coiled-coil tetramerization domain of BCR-ABL is essential for the interactions of SH2-containing signal transduction molecules. The Journal of Biological Chemistry. 272: 1389-94. PMID 8995449 DOI: 10.1074/Jbc.272.2.1389  0.401
1997 Yin T, Shen R, Feng G, Yang Y. Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. Journal of Biological Chemistry. 272: 1032-1037. PMID 8995399 DOI: 10.1074/Jbc.272.2.1032  0.417
1996 Feng G, Ouyang Y, Hu D, Shi Z, Gentz R, Ni J. Grap Is a Novel SH3-SH2-SH3 Adaptor Protein That Couples Tyrosine Kinases to the Ras Pathway Journal of Biological Chemistry. 271: 12129-12132. PMID 8647802 DOI: 10.1074/Jbc.271.21.12129  0.405
1996 Marengère LE, Waterhouse P, Duncan GS, Mittrücker HW, Feng GS, Mak TW. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science (New York, N.Y.). 272: 1170-3. PMID 8638161 DOI: 10.1126/Science.272.5265.1170  0.401
1994 Feng G, Pawson T. Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction Trends in Genetics. 10: 54-58. PMID 8191586 DOI: 10.1016/0168-9525(94)90149-X  0.394
1993 Kozlowski M, Mlinaric-Rascan I, Feng G, Shen R, Pawson T, Siminovitch KA. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. Journal of Experimental Medicine. 178: 2157-2163. PMID 8245788 DOI: 10.1084/Jem.178.6.2157  0.361
1993 Feng G, Hui C, Pawson T. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases Science. 259: 1607-1611. PMID 8096088 DOI: 10.1126/Science.8096088  0.427
1993 Kazlauskas A, Feng GS, Pawson T, Valius M. The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proceedings of the National Academy of Sciences of the United States of America. 90: 6939-43. PMID 7688466 DOI: 10.1073/Pnas.90.15.6939  0.377
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