| Year |
Citation |
Score |
| 2013 |
Million M, Zhao JF, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Taché Y. The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. Plos One. 8: e73749. PMID 24040053 DOI: 10.1371/journal.pone.0073749 |
0.435 |
|
| 2013 |
Ashby CR, Kehne JH, Bartoszyk GD, Renda MJ, Athanasiou M, Pierz KA, Seyfried CA. Electrophysiological evidence for rapid 5-HT₁A autoreceptor inhibition by vilazodone, a 5-HT₁A receptor partial agonist and 5-HT reuptake inhibitor. European Journal of Pharmacology. 714: 359-65. PMID 23872377 DOI: 10.1016/J.Ejphar.2013.07.014 |
0.365 |
|
| 2013 |
Million M, Zhao J, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Taché Y. Oro-gastric (og) administration of NGD CRF 1 antagonist, NGD 98-2 or NGD 9002 reduces acute water avoidance stress (WAS)-induced stimulation of colonic propulsive motor function in rats. Plos One. DOI: 10.1371/Journal.Pone.0073749.G005 |
0.319 |
|
| 2012 |
Cain CK, Maynard GD, Kehne JH. Targeting memory processes with drugs to prevent or cure PTSD. Expert Opinion On Investigational Drugs. 21: 1323-50. PMID 22834476 DOI: 10.1517/13543784.2012.704020 |
0.564 |
|
| 2012 |
Kwentus J, Riesenberg RA, Marandi M, Manning RA, Allen MH, Fishman RS, Spyker DA, Kehne JH, Cassella JV. Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine. Bipolar Disorders. 14: 31-40. PMID 22329470 DOI: 10.1111/j.1399-5618.2011.00975.x |
0.322 |
|
| 2011 |
Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. Journal of Medicinal Chemistry. 54: 4187-206. PMID 21618986 DOI: 10.1021/jm200365y |
0.387 |
|
| 2011 |
Lesem MD, Tran-Johnson TK, Riesenberg RA, Feifel D, Allen MH, Fishman R, Spyker DA, Kehne JH, Cassella JV. Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine. The British Journal of Psychiatry : the Journal of Mental Science. 198: 51-8. PMID 21200077 DOI: 10.1192/bjp.bp.110.081513 |
0.312 |
|
| 2011 |
Rowlett JK, Kehne JH, Sprenger KJ, Maynard GD. Emergence of anti-conflict effects of zolpidem in rhesus monkeys following extended post-injection intervals. Psychopharmacology. 214: 855-62. PMID 21103864 DOI: 10.1007/S00213-010-2093-3 |
0.353 |
|
| 2010 |
Kehne JH, Cain CK. Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal models. Pharmacology & Therapeutics. 128: 460-87. PMID 20826181 DOI: 10.1016/j.pharmthera.2010.08.011 |
0.605 |
|
| 2010 |
Jackson MJ, Andree TH, Hansard M, Hoffman DC, Hurtt MR, Kehne JH, Pitler TA, Smith LA, Stack G, Jenner P. The dopamine D(2) receptor partial agonist aplindore improves motor deficits in MPTP-treated common marmosets alone and combined with L-dopa. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 55-67. PMID 19809864 DOI: 10.1007/S00702-009-0323-9 |
0.346 |
|
| 2008 |
Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Krause JE, Hutchison A, Horvath RF, Ge P, Kehne J, Hoffman D, Chandrasekhar J, Doller D, Hodgetts KJ. 2-Arylpyrimidines: novel CRF-1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 18: 4486-90. PMID 18672365 DOI: 10.1016/J.Bmcl.2008.07.063 |
0.343 |
|
| 2008 |
Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Chandrasekhar J, Horvath RF, Ge P, Kershaw MT, Krause JE, Kehne J, Hoffman D, Doller D, Hodgetts KJ. The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 18: 891-6. PMID 18180159 DOI: 10.1016/J.Bmcl.2007.12.050 |
0.32 |
|
| 2008 |
Kehne JH, Maynard GD. CRF1 receptor antagonists: treatment of stress-related disorders Drug Discovery Today: Therapeutic Strategies. 5: 161-168. DOI: 10.1016/j.ddstr.2008.09.003 |
0.377 |
|
| 2003 |
Kehne JH, Maynard GD, De Lombaert S, Krause JE. Chapter 2. Neuropeptide receptor antagonists for CNS disorders Annual Reports in Medicinal Chemistry. 38: 11-20. DOI: 10.1016/S0065-7743(03)38003-0 |
0.354 |
|
| 2000 |
Kehne JH, Coverdale S, McCloskey TC, Hoffman DC, Cassella JV. Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups. Neuropharmacology. 39: 1357-67. PMID 10818252 DOI: 10.1016/S0028-3908(00)00043-5 |
0.464 |
|
| 1998 |
Kehne JH, Hoffman DC, Cassella JV. Models of Schizophrenia: Phencyclidine Disruption of Prepulse Inhibition (
PPI
) of Startle in Rats Current Protocols in Pharmacology. 3. DOI: 10.1002/0471141755.ph0515s03 |
0.309 |
|
| 1997 |
Feldman DJ, Frank RA, Kehne JH, Flannery R, Brown D, Soni S, Byrd G, Shah S. Mixed D2/5-HT2 antagonism differentially affects apomorphine- and amphetamine-induced stereotyped behavior. Pharmacology, Biochemistry, and Behavior. 58: 565-72. PMID 9300620 DOI: 10.1016/S0091-3057(97)00292-X |
0.366 |
|
| 1997 |
Baron BM, Harrison BL, Kehne JH, Schmidt CJ, van Giersbergen PL, White HS, Siegel BW, Senyah Y, McCloskey TC, Fadayel GM, Taylor VL, Murawsky MK, Nyce P, Salituro FG. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. European Journal of Pharmacology. 323: 181-92. PMID 9128837 DOI: 10.1016/S0014-2999(97)00045-9 |
0.361 |
|
| 1996 |
Padich RA, McCloskey TC, Kehne JH. 5-HT modulation of auditory and visual sensorimotor gating: II. Effects of the 5-HT2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats. Psychopharmacology. 124: 107-16. PMID 8935805 DOI: 10.1007/Bf02245610 |
0.406 |
|
| 1996 |
Kehne JH, Padich RA, McCloskey TC, Taylor VL, Schmidt CJ. 5-HT modulation of auditory and visual sensorimotor gating: I. Effects of 5-HT releasers on sound and light prepulse inhibition in Wistar rats. Psychopharmacology. 124: 95-106. PMID 8935804 DOI: 10.1007/BF02245609 |
0.344 |
|
| 1996 |
Kehne JH, Ketteler HJ, McCloskey TC, Sullivan CK, Dudley MW, Schmidt CJ. Effects of the selective 5-HT2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 116-24. PMID 8840347 DOI: 10.1016/0893-133X(95)00160-F |
0.3 |
|
| 1996 |
Moser PC, Moran PM, Frank RA, Kehne JH. Reversal of amphetamine-induced behaviours by MDL 100,907, a selective 5-HT2A antagonist. Behavioural Brain Research. 73: 163-7. PMID 8788496 DOI: 10.1016/0166-4328(96)00090-3 |
0.335 |
|
| 1996 |
Kehne JH, Baron BM, Carr AA, Chaney SF, Elands J, Feldman DJ, Frank RA, van Giersbergen PL, McCloskey TC, Johnson MP, McCarty DR, Poirot M, Senyah Y, Siegel BW, Widmaier C. Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. The Journal of Pharmacology and Experimental Therapeutics. 277: 968-81. PMID 8627580 |
0.338 |
|
| 1996 |
Schmidt C, Fadayel G, Sorensen S, Kehne J. Rationale for the use of a selective 5-HT2A receptor antagonist in the treatment of schizophrenia Schizophrenia Research. 18: 142. DOI: 10.1016/0920-9964(96)85468-5 |
0.316 |
|
| 1995 |
Kehne JH, Baron BM, Harrison BL, McCloskey TC, Palfreyman MG, Poirot M, Salituro FG, Siegel BW, Slone AL, Van Giersbergen PL. MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles. European Journal of Pharmacology. 284: 109-18. PMID 8549613 DOI: 10.1016/0014-2999(95)00375-U |
0.326 |
|
| 1995 |
Kehne JH, McCloskey TC, Padich RA. Dopaminergic, glutamatergic, and serotonergic modulation of sensory gating: Use of prepulse inhibition for evaluating antipsychotic activity and psychotomimetic potential of novel therapeutic compounds Schizophrenia Research. 15: 154. DOI: 10.1016/0920-9964(95)95478-R |
0.302 |
|
| 1992 |
Kehne JH, McCloskey TC, Taylor VL, Black CK, Fadayel GM, Schmidt CJ. Effects of the serotonin releasers 3,4-methylenedioxymethamphetamine (MDMA), 4-chloroamphetamine (PCA) and fenfluramine on acoustic and tactile startle reflexes in rats. The Journal of Pharmacology and Experimental Therapeutics. 260: 78-89. PMID 1731054 |
0.305 |
|
| 1991 |
Kehne JH, McCloskey TC, Baron BM, Chi EM, Harrison BL, Whitten JP, Palfreyman MG. NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations. European Journal of Pharmacology. 193: 283-92. PMID 1675993 DOI: 10.1016/0014-2999(91)90141-C |
0.38 |
|
| 1991 |
Kehne JH, Boulis NM, Davis M. Effects of the phosphodiesterase inhibitor rolipram on the acoustic startle response in rats. Psychopharmacology. 105: 27-36. PMID 1660609 DOI: 10.1007/Bf02316860 |
0.561 |
|
| 1990 |
Boulis NM, Kehne JH, Miserendino MJ, Davis M. Differential blockade of early and late components of acoustic startle following intrathecal infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) or D,L-2-amino-5-phosphonovaleric acid (AP-5). Brain Research. 520: 240-6. PMID 1976408 DOI: 10.1016/0006-8993(90)91711-O |
0.491 |
|
| 1989 |
Davis M, Commissaris RL, Yang S, Wagner KR, Kehne JH, Cassella JV, Boulis NM. Spinal vs. supraspinal sites of action of the alpha 2-adrenergic agonists clonidine and ST-91 on the acoustic startle reflex. Pharmacology, Biochemistry, and Behavior. 33: 233-40. PMID 2571168 DOI: 10.1016/0091-3057(89)90455-3 |
0.512 |
|
| 1988 |
Kehne JH, Cassella JV, Davis M. Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm. Psychopharmacology. 94: 8-13. PMID 2894703 DOI: 10.1007/BF00735872 |
0.49 |
|
| 1988 |
Davis M, Cassella JV, Kehne JH. Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone. Psychopharmacology. 94: 14-20. PMID 2894698 DOI: 10.1007/BF00735873 |
0.518 |
|
| 1987 |
Kehne JH, Cassella JV, Aghajanian GK, Tallman JF, Davis M. Pertussis toxin or 8-bromo-cAMP block inhibition of the acoustic startle response by the alpha 2-adrenergic agonist ST-91. Brain Research. 406: 87-92. PMID 3032362 DOI: 10.1016/0006-8993(87)90771-2 |
0.499 |
|
| 1986 |
Kehne J, Astrachan D, Astrachan E, Tallman J, Davis M. The role of spinal cord cyclic AMP in the acoustic startle response in rats The Journal of Neuroscience. 6: 3250-3257. DOI: 10.1523/Jneurosci.06-11-03250.1986 |
0.493 |
|
| 1985 |
Kehne JH, Davis M. Central noradrenergic involvement in yohimbine excitation of acoustic startle: effects of DSP4 and 6-OHDA. Brain Research. 330: 31-41. PMID 3921192 DOI: 10.1016/0006-8993(85)90005-8 |
0.514 |
|
| 1985 |
Kehne JH, Gallager DW, Davis M. Spinalization unmasks clonidine's alpha 1-adrenergic mediated excitation of the flexor reflex in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 1583-90. PMID 2861260 |
0.3 |
|
| 1985 |
Davis M, Kehne JH, Commissaris RL. Antagonism of apomorphine-enhanced startle by alpha 1-adrenergic antagonists. European Journal of Pharmacology. 108: 233-41. PMID 2859209 DOI: 10.1016/0014-2999(85)90445-5 |
0.513 |
|
| 1985 |
Kehne J, Gallager D, Davis M. Spinalization unmasks clonidine's alpha 1-adrenergic mediated excitation of the flexor reflex in rats The Journal of Neuroscience. 5: 1583-1590. DOI: 10.1523/Jneurosci.05-06-01583.1985 |
0.499 |
|
| 1984 |
Kehne JH, Davis M. Strychnine increases acoustic startle amplitude but does not alter short-term or long-term habituation. Behavioral Neuroscience. 98: 955-68. PMID 6095880 DOI: 10.1037//0735-7044.98.6.955 |
0.463 |
|
| 1983 |
Marwaha J, Kehne JH, Commissaris RL, Lakoski J, Shaw W, Davis M. Spinal clonidine inhibits neural firing in locus coeruleus. Brain Research. 276: 379-83. PMID 6414650 DOI: 10.1016/0006-8993(83)90752-7 |
0.467 |
|
| 1983 |
Gallager DW, Kehne JH, Wakeman EA, Davis M. Development changes in pharmacological responsivity of the acoustic startle reflex: effects of picrotoxin. Psychopharmacology. 79: 87-93. PMID 6405442 DOI: 10.1007/BF00427790 |
0.488 |
|
| 1983 |
Menkes DB, Kehne JH, Gallager DW, Aghajanian GK, Davis M. Functional supersensitivity of CNS alpha 1-adrenoceptors following chronic antidepressant treatment. Life Sciences. 33: 181-8. PMID 6306376 DOI: 10.1016/0024-3205(83)90411-3 |
0.505 |
|
| 1982 |
Davis M, Parisi T, Gendelman DS, Tischler M, Kehne JH. Habituation and sensitization of startle reflexes elicited electrically from the brainstem. Science (New York, N.Y.). 218: 688-90. PMID 7134967 DOI: 10.1126/science.7134967 |
0.414 |
|
| 1981 |
Kehne JH, Gallager DW, Davis M. Strychnine: brainstem and spinal mediation of excitatory effects on acoustic startle. European Journal of Pharmacology. 76: 177-86. PMID 7333355 DOI: 10.1016/0014-2999(81)90499-4 |
0.53 |
|
| Show low-probability matches. |