| Year |
Citation |
Score |
| 2024 |
Aghavali R, Roberts EG, Kurokawa YK, Mak E, Chan MYC, Wong AOT, Li RA, Costa KD. Enhanced Drug Classification Using Machine Learning with Multiplexed Cardiac Contractility Assays. Pharmacological Research. 107459. PMID 39396765 DOI: 10.1016/j.phrs.2024.107459 |
0.33 |
|
| 2023 |
Chan CH, Lam YY, Wong N, Geng L, Zhang J, Ahola V, Zare A, Li RA, Lanner F, Keung W, Cheung YF. Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome. Communications Biology. 6: 969. PMID 37740059 DOI: 10.1038/s42003-023-05344-6 |
0.394 |
|
| 2023 |
Cheng S, Brenière-Letuffe D, Ahola V, Wong AOT, Keung HY, Gurung B, Zheng Z, Costa KD, Lieu DK, Keung W, Li RA. Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues. Iscience. 26: 106302. PMID 36950112 DOI: 10.1016/j.isci.2023.106302 |
0.441 |
|
| 2021 |
Gurung B, Tse G, Keung W, Li RA, Wong WT. Arrhythmic Risk Assessment of Hypokalaemia Using Human Pluripotent Stem Cell-Derived Cardiac Anisotropic Sheets. Frontiers in Cell and Developmental Biology. 9: 681665. PMID 34938727 DOI: 10.3389/fcell.2021.681665 |
0.324 |
|
| 2020 |
Wong AO, Gurung B, Wong WS, Mak SY, Tse WW, Li CM, Lieu DK, Costa KD, Li RA, Hajjar RJ. Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues. Journal of Molecular and Cellular Cardiology. PMID 33373642 DOI: 10.1016/j.yjmcc.2020.12.014 |
0.365 |
|
| 2020 |
Mehrotra S, de Melo BAG, Hirano M, Keung W, Li RA, Mandal BB, Shin SR. Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium-on-a-Chip Application. Advanced Functional Materials. 30. PMID 33071707 DOI: 10.1002/adfm.201907436 |
0.396 |
|
| 2020 |
Lam YY, Keung W, Chan CH, Geng L, Wong N, Brenière-Letuffe D, Li RA, Cheung YF. Single-Cell Transcriptomics of Engineered Cardiac Tissues From Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome. Journal of the American Heart Association. e016528. PMID 33059525 DOI: 10.1161/JAHA.120.016528 |
0.446 |
|
| 2020 |
Wong AO, Wong N, Geng L, Chow MZ, Lee EK, Wu H, Khine M, Kong CW, Costa KD, Keung W, Cheung YF, Li RA. Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients. Frontiers in Physiology. 11: 165. PMID 32226389 DOI: 10.3389/Fphys.2020.00165 |
0.378 |
|
| 2020 |
Y Wong GK, Costa KD, Fermini B, Li RA. Modeling the heart with Novoheart’s MyHeart™ platform Future Drug Discovery. 2: FDD32. DOI: 10.4155/fdd-2020-0003 |
0.323 |
|
| 2019 |
Keung W, Chan PK, Backeris P, Lee EK, Wong N, Wong GK, Chan CW, Fermini B, Costa KD, Li RA. Human cardiac ventricular organoid chambers and tissue strips from pluripotent stem cells as a two-tiered assay for inotropic responses: A blinded validation. Journal of Pharmacological and Toxicological Methods. 99: 106595. PMID 31962924 DOI: 10.1016/J.Vascn.2019.05.174 |
0.402 |
|
| 2019 |
Wong AO, Lieu DK, Wong GK, Gurung B, Tse WW, Costa KD, Chan CW, Nabhan JD, Li RA. Modeling cardiac dysfunction of Friedreich's ataxia using ventricular sheets, tissues and chambers engineered from human pluripotent stem cells. Journal of Pharmacological and Toxicological Methods. 99: 106595. PMID 31962923 DOI: 10.1016/J.Vascn.2019.05.175 |
0.405 |
|
| 2019 |
Shum A, Wong AO, Chan CW, Costa KD, Khine M, Kong CW, Li RA. Directly visualizing drug-induced arrhythmias with aligned human pluripotent stem cell-based ventricular cardiac anisotropic sheet. Journal of Pharmacological and Toxicological Methods. 99: 106595. PMID 31962922 DOI: 10.1016/J.Vascn.2019.05.176 |
0.359 |
|
| 2019 |
Li RA, Keung W, Cashman T, Backeris P, Johnson BV, Bardot ES, Wong AO, Chan PK, Chan CW, Costa KD. "Human heart-in-a-Jar": An electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells. Journal of Pharmacological and Toxicological Methods. 99: 106595. PMID 31962919 DOI: 10.1016/J.Vascn.2019.05.178 |
0.332 |
|
| 2019 |
Wong AO, Chan CW, Costa KD, Li RA. Controlled physiomimetic preload augments inotropic sensitivity and contractile phenotypes in human pluripotent stem cell-derived engineered cardiac tissues and chambers. Journal of Pharmacological and Toxicological Methods. 99: 106595. PMID 31962918 DOI: 10.1016/J.Vascn.2019.05.179 |
0.412 |
|
| 2019 |
Keung W, Lam YY, Chan CH, Geng L, Cheung YF, Li RA. Modeling the congenital heart condition of pulmonary atresia with intact ventricular septum using human induced pluripotent stem cells. Journal of Pharmacological and Toxicological Methods. 99: 106595. PMID 31962916 DOI: 10.1016/j.vascn.2019.05.181 |
0.313 |
|
| 2019 |
Li S, Chopra A, Keung W, Chan C, Costa KD, Kong CW, Hajjar RJ, Chen C, Li R. Sarco/Endoplasmic Reticulum Ca-ATPase is a more effective calcium remover than Sodium-Calcium Exchanger in human embryonic stem cell-derived cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31347915 DOI: 10.1152/Ajpheart.00540.2018 |
0.311 |
|
| 2019 |
Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA. Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells. Stem Cell Research & Therapy. 10: 203. PMID 31286988 DOI: 10.1186/S13287-019-1305-Y |
0.433 |
|
| 2019 |
Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA. Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues. Scientific Reports. 9: 7502. PMID 31097748 DOI: 10.1038/S41598-019-42953-W |
0.49 |
|
| 2019 |
Li S, Keung W, Cheng H, Li RA. Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes. Stem Cells International. 2019: 8765752. PMID 31065282 DOI: 10.1155/2019/8765752 |
0.303 |
|
| 2019 |
Keung W, Chan PKW, Backeris PC, Lee EK, Wong N, Wong AOT, Wong GKY, Chan CWY, Fermini B, Costa KD, Li RA. Human cardiac ventricular-like organoid chambers and tissue strips from pluripotent stem cells as a two-tiered assay for inotropic responses. Clinical Pharmacology and Therapeutics. PMID 30723889 DOI: 10.1002/Cpt.1385 |
0.366 |
|
| 2018 |
Geng L, Kong CW, Won AOT, Shum AM, Chow MZY, Che H, Zhang C, Yau KL, Chan CW, Keung W, Li RA. Probing flecainide block of I using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers. Toxicology Letters. PMID 29758359 DOI: 10.1016/j.toxlet.2018.05.006 |
0.41 |
|
| 2018 |
Ceholski DK, Turnbull IC, Kong CW, Koplev S, Mayourian J, Gorski PA, Stillitano F, Skodras AA, Nonnenmacher M, Cohen N, Björkegren JLM, Stroik DR, Cornea RL, Thomas DD, Li RA, et al. Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes. Journal of Molecular and Cellular Cardiology. PMID 29752948 DOI: 10.1016/J.Yjmcc.2018.05.007 |
0.366 |
|
| 2018 |
Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, ... ... Li RA, et al. Human ISL1Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29606507 DOI: 10.1016/J.Ymthe.2018.02.012 |
0.376 |
|
| 2018 |
Li RA, Keung W, Cashman TJ, Backeris PC, Johnson BV, Bardot ES, Wong AOT, Chan PKW, Chan CWY, Costa KD. Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells. Biomaterials. 163: 116-127. PMID 29459321 DOI: 10.1016/J.Biomaterials.2018.02.024 |
0.446 |
|
| 2018 |
Kong CW, Geng L, Li RA. High-Content Electrophysiological Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes (hPSC-CMs). Methods in Molecular Biology (Clifton, N.J.). 1722: 185-194. PMID 29264806 DOI: 10.1007/978-1-4939-7553-2_12 |
0.36 |
|
| 2017 |
Lee EK, Tran DD, Keung W, Chan P, Wong G, Chan CW, Costa KD, Li RA, Khine M. Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification. Stem Cell Reports. PMID 29033305 DOI: 10.1016/J.Stemcr.2017.09.008 |
0.332 |
|
| 2017 |
Chan PKW, Geng L, Gao Y, Keung W, Li RA. AAV-mediated conversion of human pluripotent stem cell-derived pacemaker. Biochemical and Biophysical Research Communications. PMID 28989025 DOI: 10.1016/j.bbrc.2017.10.023 |
0.397 |
|
| 2017 |
Sun Y, Timofeyev V, Dennis A, Bektik E, Wan X, Laurita KR, Deschênes I, Li RA, Fu JD. A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1 -Induced Activation of Pacemaker Current. Stem Cell Reviews. PMID 28623610 DOI: 10.1007/S12015-017-9745-1 |
0.356 |
|
| 2017 |
Stillitano F, Hansen J, Kong CW, Karakikes I, Funck-Brentano C, Geng L, Scott S, Reynier S, Wu M, Valogne Y, Desseaux C, Salem JE, Jeziorowska D, Zahr N, Li R, et al. Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells. Elife. 6. PMID 28134617 DOI: 10.7554/Elife.19406 |
0.463 |
|
| 2017 |
Kong CW, Chen S, Geng L, Shum AM, Sun D, Li RA. Increasing the physical size and nucleation status of human pluripotent stem cell-derived ventricular cardiomyocytes by cell fusion. Stem Cell Research. 19: 76-81. PMID 28086122 DOI: 10.1016/J.Scr.2017.01.003 |
0.361 |
|
| 2017 |
Chan PK, Li RA. Gene Delivery for the Generation of Bioartificial Pacemaker. Methods in Molecular Biology (Clifton, N.J.). 1521: 293-306. PMID 27910058 DOI: 10.1007/978-1-4939-6588-5_21 |
0.325 |
|
| 2016 |
Shum AM, Che H, Wong AO, Zhang C, Wu H, Chan CW, Costa K, Khine M, Kong CW, Li RA. A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity. Advanced Materials (Deerfield Beach, Fla.). PMID 27805726 DOI: 10.1002/Adma.201602448 |
0.362 |
|
| 2016 |
Keung W, Ren L, Sen Li, Wong AO, Chopra A, Kong CW, Tomaselli GF, Chen CS, Li RA. Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels. Scientific Reports. 6: 34154. PMID 27677332 DOI: 10.1038/Srep34154 |
0.411 |
|
| 2016 |
Cashman TJ, Josowitz R, Gelb BD, Li RA, Dubois NC, Costa KD. Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy. Journal of Visualized Experiments : Jove. PMID 26967678 DOI: 10.3791/53447 |
0.402 |
|
| 2016 |
Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, et al. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nature Communications. 7: 10774. PMID 26952167 DOI: 10.1038/Ncomms10774 |
0.323 |
|
| 2016 |
Stillitano F, Hansen J, Kong C, Karakikes I, Funck-Brentano C, Geng L, Scott S, Reynier S, Wu M, Valogne Y, Desseaux C, Salem J, Jeziorowska D, Zahr N, Li R, et al. Author response: Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells Elife. DOI: 10.7554/Elife.19406.023 |
0.343 |
|
| 2016 |
Smet MD, Doisne N, Stillitano F, Lissoni A, Wang N, Leybaert L, Grauso M, Mougenot N, Clergue M, Coulombe A, Guicheney P, Neyroud N, Kong C, Hansen J, Funck-Brentano C, ... ... Li R, et al. Control of Rhythm and Rate278Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis279Exploration of the dominant-negative effect of a SCN5A mutation in mice using adeno-associated viruses280Modeling susceptibility to drug-induced long qt syndrome with a panel of subject-specific induced pluripotent stem cells Cardiovascular Research. 111. DOI: 10.1093/Cvr/Cvw140 |
0.538 |
|
| 2015 |
Qi Y, Li Z, Kong CW, Tang NL, Huang Y, Li RA, Yao X. Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes. Journal of Molecular and Cellular Cardiology. 87: 65-73. PMID 26259779 DOI: 10.1016/J.Yjmcc.2015.08.005 |
0.422 |
|
| 2015 |
Poon E, Keung W, Liang Y, Ramalingam R, Yan B, Zhang S, Chopra A, Moore J, Herren A, Lieu DK, Wong HS, Weng Z, Wong OT, Lam YW, Tomaselli GF, ... ... Li RA, et al. Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation. Circulation. Cardiovascular Genetics. 8: 427-36. PMID 25759434 DOI: 10.1161/Circgenetics.114.000918 |
0.4 |
|
| 2015 |
Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA. Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs. Circulation. Arrhythmia and Electrophysiology. 8: 193-202. PMID 25504561 DOI: 10.1161/Circep.114.002049 |
0.416 |
|
| 2015 |
Chen Y, Wang J, Shen B, Chan CW, Wang C, Zhao Y, Chan HN, Tian Q, Chen Y, Yao C, Hsing IM, Li RA, Wu H. Engineering a freestanding biomimetic cardiac patch using biodegradable poly(lactic-co-glycolic acid) (PLGA) and human embryonic stem cell-derived ventricular cardiomyocytes (hESC-VCMs). Macromolecular Bioscience. 15: 426-36. PMID 25420623 DOI: 10.1002/Mabi.201400448 |
0.359 |
|
| 2015 |
Qi Y, Li Z, Kong CW, Tang NL, Huang Y, Li RA, Yao X. Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes Journal of Molecular and Cellular Cardiology. 87: 65-73. DOI: 10.1016/j.yjmcc.2015.08.005 |
0.303 |
|
| 2014 |
Li RA. Cardiovascular regeneration. Stem Cell Research & Therapy. 5: 141. PMID 25689157 DOI: 10.1186/scrt531 |
0.354 |
|
| 2014 |
Weng Z, Kong CW, Ren L, Karakikes I, Geng L, He J, Chow MZ, Mok CF, Keung W, Chow H, Leung AY, Hajjar RJ, Li RA, Chan CW. A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. Stem Cells and Development. 23: 1704-16. PMID 24564569 DOI: 10.1089/scd.2013.0509 |
0.332 |
|
| 2014 |
Keung W, Boheler KR, Li RA. Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes. Stem Cell Research & Therapy. 5: 17. PMID 24467782 DOI: 10.1186/scrt406 |
0.313 |
|
| 2014 |
Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ. Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Translational Medicine. 3: 18-31. PMID 24324277 DOI: 10.5966/Sctm.2013-0110 |
0.364 |
|
| 2014 |
Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee JJ, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot JS, Costa KD. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 644-54. PMID 24174427 DOI: 10.1096/Fj.13-228007 |
0.396 |
|
| 2014 |
Meng X, Shen J, Kong M, Brady R, Li RA, Schiffmann R. Abnormal intracellular calcium handling: a key pathogenic and therapeutic target of the cardiac manifestations in Fabry disease Molecular Genetics and Metabolism. 111: S77. DOI: 10.1016/J.Ymgme.2013.12.177 |
0.343 |
|
| 2013 |
Poon E, Yan B, Zhang S, Rushing S, Keung W, Ren L, Lieu DK, Geng L, Kong CW, Wang J, Wong HS, Boheler KR, Li RA. Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation. Plos One. 8: e77784. PMID 24204964 DOI: 10.1371/Journal.Pone.0077784 |
0.38 |
|
| 2013 |
Li S, Chen G, Li RA. Calcium signalling of human pluripotent stem cell-derived cardiomyocytes. The Journal of Physiology. 591: 5279-90. PMID 24018947 DOI: 10.1113/jphysiol.2013.256495 |
0.391 |
|
| 2013 |
Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Research. 23: 1172-86. PMID 24018375 DOI: 10.1038/Cr.2013.112 |
0.319 |
|
| 2013 |
Chow M, Boheler KR, Li RA. Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery and disease modeling: from the genetic, epigenetic, and tissue modeling perspectives. Stem Cell Research & Therapy. 4: 97. PMID 23953772 DOI: 10.1186/scrt308 |
0.372 |
|
| 2013 |
Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 34: 8878-86. PMID 23942210 DOI: 10.1016/J.Biomaterials.2013.07.039 |
0.393 |
|
| 2013 |
Jiang P, Chen C, Liu XB, Selvaraj V, Liu W, Feldman DH, Liu Y, Pleasure DE, Li RA, Deng W. Generation and characterization of spiking and nonspiking oligodendroglial progenitor cells from embryonic stem cells. Stem Cells (Dayton, Ohio). 31: 2620-31. PMID 23940003 DOI: 10.1002/Stem.1515 |
0.316 |
|
| 2013 |
Chow MZ, Geng L, Kong CW, Keung W, Fung JC, Boheler KR, Li RA. Epigenetic regulation of the electrophysiological phenotype of human embryonic stem cell-derived ventricular cardiomyocytes: insights for driven maturation and hypertrophic growth. Stem Cells and Development. 22: 2678-90. PMID 23656529 DOI: 10.1089/scd.2013.0125 |
0.444 |
|
| 2013 |
Lieu DK, Fu JD, Chiamvimonvat N, Tung KC, McNerney GP, Huser T, Keller G, Kong CW, Li RA. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circulation. Arrhythmia and Electrophysiology. 6: 191-201. PMID 23392582 DOI: 10.1161/Circep.111.973420 |
0.362 |
|
| 2013 |
Liao SY, Tse HF, Chan YC, Mei-Chu Yip P, Zhang Y, Liu Y, Li RA. Overexpression of Kir2.1 channel in embryonic stem cell-derived cardiomyocytes attenuates posttransplantation proarrhythmic risk in myocardial infarction. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 273-82. PMID 23041574 DOI: 10.1016/J.Hrthm.2012.10.008 |
0.335 |
|
| 2012 |
Turnbull IC, Lieu DK, Li RA, Costa KD. Cardiac tissue engineering using human stem cell-derived cardiomyocytes for disease modeling and drug discovery. Drug Discovery Today. Disease Models. 9: e219-e227. PMID 33968153 DOI: 10.1016/j.ddmod.2012.11.001 |
0.395 |
|
| 2012 |
Lieu DK, Turnbull IC, Costa KD, Li RA. Engineered human pluripotent stem cell-derived cardiac cells and tissues for electrophysiological studies. Drug Discovery Today. Disease Models. 9: e209-e217. PMID 29422934 DOI: 10.1016/J.Ddmod.2012.06.002 |
0.408 |
|
| 2012 |
Lui KO, Bu L, Li RA, Chan CW. Pluripotent stem cell-based heart regeneration: from the developmental and immunological perspectives. Birth Defects Research. Part C, Embryo Today : Reviews. 96: 98-108. PMID 22457181 DOI: 10.1002/bdrc.21004 |
0.383 |
|
| 2012 |
Tan Y, Kong CW, Chen S, Cheng SH, Li RA, Sun D. Probing the mechanobiological properties of human embryonic stem cells in cardiac differentiation by optical tweezers. Journal of Biomechanics. 45: 123-8. PMID 22104169 DOI: 10.1016/J.Jbiomech.2011.09.007 |
0.337 |
|
| 2012 |
Awasthi S, Matthews DL, Li RA, Chiamvimonvat N, Lieu DK, Chan JW. Label-free identification and characterization of human pluripotent stem cell-derived cardiomyocytes using second harmonic generation (SHG) microscopy. Journal of Biophotonics. 5: 57-66. PMID 22083829 DOI: 10.1002/Jbio.201100077 |
0.303 |
|
| 2012 |
Sirish P, López JE, Li N, Wong A, Timofeyev V, Young JN, Majdi M, Li RA, Chen HS, Chiamvimonvat N. MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts. Journal of Molecular and Cellular Cardiology. 52: 264-72. PMID 22062954 DOI: 10.1016/J.Yjmcc.2011.10.012 |
0.333 |
|
| 2012 |
Turnbull IC, Lieu DK, Li RA, Costa KD. Cardiac tissue engineering using human stem cell-derived cardiomyocytes for disease modeling and drug discovery Drug Discovery Today: Disease Models. 9: e219-e227. DOI: 10.1016/J.Ddmod.2012.11.001 |
0.4 |
|
| 2012 |
Lui KO, Stachel MW, Lieu DK, Li RA, Bu L. Induced pluripotent stem cells as a disease model for studying inherited arrhythmias: Promises and hurdles Drug Discovery Today: Disease Models. 9: e199-e207. DOI: 10.1016/J.Ddmod.2012.09.001 |
0.389 |
|
| 2012 |
Lui KO, Stachel MW, Li RA, Bu L. Human pluripotent stem cell-derived cardiovascular progenitors for heart regeneration Drug Discovery Today: Disease Models. 9: e189-e197. DOI: 10.1016/j.ddmod.2012.08.003 |
0.327 |
|
| 2012 |
Lieu DK, Turnbull IC, Costa KD, Li RA. Engineered human pluripotent stem cell-derived cardiac cells and tissues for electrophysiological studies Drug Discovery Today: Disease Models. 9: e209-e217. DOI: 10.1016/j.ddmod.2012.06.002 |
0.408 |
|
| 2011 |
Ng KM, Chan YC, Lee YK, Lai WH, Au KW, Fung ML, Siu CW, Li RA, Tse HF. Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level. Cellular Reprogramming. 13: 527-37. PMID 22029419 DOI: 10.1089/Cell.2011.0038 |
0.426 |
|
| 2011 |
Poon E, Kong CW, Li RA. Human pluripotent stem cell-based approaches for myocardial repair: from the electrophysiological perspective. Molecular Pharmaceutics. 8: 1495-504. PMID 21879736 DOI: 10.1021/mp2002363 |
0.392 |
|
| 2011 |
Zhang J, Calafiore M, Zeng Q, Zhang X, Huang Y, Li RA, Deng W, Zhao M. Electrically guiding migration of human induced pluripotent stem cells. Stem Cell Reviews. 7: 987-96. PMID 21373881 DOI: 10.1042/Cbi034S042D |
0.316 |
|
| 2011 |
Luna JI, Ciriza J, Garcia-Ojeda ME, Kong M, Herren A, Lieu DK, Li RA, Fowlkes CC, Khine M, McCloskey KE. Multiscale biomimetic topography for the alignment of neonatal and embryonic stem cell-derived heart cells. Tissue Engineering. Part C, Methods. 17: 579-88. PMID 21235325 DOI: 10.1089/Ten.Tec.2010.0410 |
0.377 |
|
| 2010 |
Kong CW, Akar FG, Li RA. Translational potential of human embryonic and induced pluripotent stem cells for myocardial repair: insights from experimental models. Thrombosis and Haemostasis. 104: 30-8. PMID 20539906 DOI: 10.1160/TH10-03-0189 |
0.365 |
|
| 2010 |
Ng KM, Lee YK, Chan YC, Lai WH, Fung ML, Li RA, Siu CW, Tse HF. Exogenous expression of HIF-1 alpha promotes cardiac differentiation of embryonic stem cells. Journal of Molecular and Cellular Cardiology. 48: 1129-37. PMID 20116384 DOI: 10.1016/J.Yjmcc.2010.01.015 |
0.308 |
|
| 2010 |
Jiang P, Rushing SN, Kong CW, Fu J, Lieu DK, Chan CW, Deng W, Li RA. Electrophysiological properties of human induced pluripotent stem cells. American Journal of Physiology. Cell Physiology. 298: C486-95. PMID 19955484 DOI: 10.1152/Ajpcell.00251.2009 |
0.416 |
|
| 2010 |
Fu JD, Jiang P, Rushing S, Liu J, Chiamvimonvat N, Li RA. Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes. Stem Cells and Development. 19: 773-82. PMID 19719399 DOI: 10.1089/Scd.2009.0184 |
0.318 |
|
| 2010 |
Ng K, Chan Y, Lee Y, Lai W, Fung M, Siu C, Li RA, Tse H. P81. Cobalt chloride pre-treatment enhances the calcium handling of human embryonic stem cells-derived cardiomyocytes Differentiation. 80. DOI: 10.1016/J.Diff.2010.09.087 |
0.372 |
|
| 2009 |
Chan YC, Wang K, Au KW, Au KW, Lau CP, Tse HF, Li RA. Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels. PflüGers Archiv : European Journal of Physiology. 459: 25-38. PMID 19756722 DOI: 10.1007/S00424-009-0719-2 |
0.312 |
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| 2009 |
Chan JW, Lieu DK, Huser T, Li RA. Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy. Analytical Chemistry. 81: 1324-31. PMID 19152312 DOI: 10.1021/Ac801665M |
0.399 |
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| 2009 |
Au KW, Liao SY, Lee YK, Lai WH, Ng KM, Chan YC, Yip MC, Ho CY, Wu EX, Li RA, Siu CW, Tse HF. Effects of iron oxide nanoparticles on cardiac differentiation of embryonic stem cells. Biochemical and Biophysical Research Communications. 379: 898-903. PMID 19135029 DOI: 10.1016/J.Bbrc.2008.12.160 |
0.341 |
|
| 2008 |
Cao F, Wagner RA, Wilson KD, Xie X, Fu JD, Drukker M, Lee A, Li RA, Gambhir SS, Weissman IL, Robbins RC, Wu JC. Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. Plos One. 3: e3474. PMID 18941512 DOI: 10.1371/Journal.Pone.0003474 |
0.414 |
|
| 2008 |
Moore JC, Tsang SY, Rushing SN, Lin D, Tse HF, Chan CW, Li RA. Functional consequences of overexpressing the gap junction Cx43 in the cardiogenic potential of pluripotent human embryonic stem cells. Biochemical and Biophysical Research Communications. 377: 46-51. PMID 18823947 DOI: 10.1016/J.Bbrc.2008.09.076 |
0.362 |
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| 2008 |
Moore JC, Fu J, Chan YC, Lin D, Tran H, Tse HF, Li RA. Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state. Biochemical and Biophysical Research Communications. 372: 553-8. PMID 18503758 DOI: 10.1016/J.Bbrc.2008.05.076 |
0.35 |
|
| 2008 |
Fu JD, Jung Y, Chan CW, Li RA. An inducible transgene expression system for regulated phenotypic modification of human embryonic stem cells. Stem Cells and Development. 17: 315-24. PMID 18447646 DOI: 10.1089/scd.2007.0114 |
0.352 |
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| 2008 |
Au KW, Siu CW, Lau CP, Tse HF, Li RA. Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions. American Journal of Physiology. Cell Physiology. 294: C136-44. PMID 17989208 DOI: 10.1152/ajpcell.00340.2007 |
0.303 |
|
| 2008 |
Chan JW, Lieu DK, Huser T, Li RA. Non-invasive, label-free spectroscopic separation of human embryonic stem cells (hESCs) and their cardiac derivatives Cell Research. 18: S130-S130. DOI: 10.1038/Cr.2008.220 |
0.344 |
|
| 2008 |
Li R. Cardiac tissue regeneration: From protein engineering, gene therapy to human embryonic stem cells Cell Research. 18: S103-S103. DOI: 10.1038/cr.2008.193 |
0.406 |
|
| 2008 |
Siu D, Au K, Lau C, Tse H, Li R. Dynamic conformational changes of the P-S6 linker of the pacemaker (HCN) channels identified by sulfhydryl modification: pore-to-gate coupling model Heart Rhythm. DOI: 10.1016/J.Hrthm.2008.03.049 |
0.335 |
|
| 2007 |
Siu CW, Moore JC, Li RA. Human embryonic stem cell-derived cardiomyocytes for heart therapies. Cardiovascular & Hematological Disorders Drug Targets. 7: 145-52. PMID 17584049 |
0.352 |
|
| 2007 |
Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA. Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 115: 1839-50. PMID 17389267 DOI: 10.1161/Circulationaha.106.659391 |
0.499 |
|
| 2007 |
El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Molecular Endocrinology (Baltimore, Md.). 21: 753-64. PMID 17158221 DOI: 10.1210/Me.2006-0258 |
0.484 |
|
| 2006 |
Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA. Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation. 114: 1000-11. PMID 16923751 DOI: 10.1161/Circulationaha.106.615385 |
0.524 |
|
| 2005 |
Wang K, Xue T, Tsang SY, Van Huizen R, Wong CW, Lai KW, Ye Z, Cheng L, Au KW, Zhang J, Li GR, Lau CP, Tse HF, Li RA. Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells (Dayton, Ohio). 23: 1526-34. PMID 16091557 DOI: 10.1634/Stemcells.2004-0299 |
0.538 |
|
| 2005 |
Azene EM, Xue T, Marbán E, Tomaselli GF, Li RA. Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers. Cardiovascular Research. 67: 263-73. PMID 16005302 DOI: 10.1016/J.Cardiores.2005.03.006 |
0.653 |
|
| 2005 |
Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O' Rourke B, Marbán E. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circulation Research. 97: 159-67. PMID 15976318 DOI: 10.1161/01.Res.0000174794.22491.A0 |
0.611 |
|
| 2005 |
Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL. Human embryonic stem cells: genetic manipulation on the way to cardiac cell therapies. Reproductive Toxicology (Elmsford, N.Y.). 20: 377-91. PMID 15967632 DOI: 10.1016/J.Reprotox.2005.04.012 |
0.547 |
|
| 2005 |
Azene EM, Sang D, Tsang SY, Li RA. Pore-to-gate coupling of HCN channels revealed by a pore variant that contributes to gating but not permeation. Biochemical and Biophysical Research Communications. 327: 1131-42. PMID 15652514 DOI: 10.1016/j.bbrc.2004.12.127 |
0.329 |
|
| 2005 |
Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation. 111: 11-20. PMID 15611367 DOI: 10.1161/01.Cir.0000151313.18547.A2 |
0.643 |
|
| 2004 |
Tsang SY, Lesso H, Li RA. Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (hyperpolarization-activated cyclic nucleotide-modulated) channels by systematic length alterations. The Journal of Biological Chemistry. 279: 43752-9. PMID 15299004 DOI: 10.1074/jbc.M408747200 |
0.386 |
|
| 2003 |
Xue T, Ennis IL, Sato K, French RJ, Li RA. Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry. Biophysical Journal. 85: 2299-310. PMID 14507694 DOI: 10.1016/S0006-3495(03)74654-2 |
0.465 |
|
| 2003 |
Teshima Y, Akao M, Li RA, Chong TH, Baumgartner WA, Johnston MV, Marbán E. Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress. Stroke; a Journal of Cerebral Circulation. 34: 1796-802. PMID 12791941 DOI: 10.1161/01.STR.0000077017.60947.AE |
0.432 |
|
| 2003 |
Li RA, Hui K, French RJ, Sato K, Henrikson CA, Tomaselli GF, Marbán E. Dependence of mu-conotoxin block of sodium channels on ionic strength but not on the permeating [Na+]: implications for the distinctive mechanistic interactions between Na+ and K+ channel pore-blocking toxins and their molecular targets. The Journal of Biological Chemistry. 278: 30912-9. PMID 12764145 DOI: 10.1074/jbc.M301039200 |
0.481 |
|
| 2003 |
Henrikson CA, Xue T, Dong P, Sang D, Marban E, Li RA. Identification of a surface charged residue in the S3-S4 linker of the pacemaker (HCN) channel that influences activation gating. The Journal of Biological Chemistry. 278: 13647-54. PMID 12582169 DOI: 10.1074/Jbc.M211025200 |
0.595 |
|
| 2003 |
Azene EM, Xue T, Li RA. Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels. The Journal of Physiology. 547: 349-56. PMID 12562911 DOI: 10.1113/Jphysiol.2003.039768 |
0.518 |
|
| 2003 |
Li RA, Ennis IL, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E. Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels. The Journal of Biological Chemistry. 278: 8717-24. PMID 12471026 DOI: 10.1074/Jbc.M210882200 |
0.567 |
|
| 2002 |
Xue T, Li RA. An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification. The Journal of Biological Chemistry. 277: 46233-42. PMID 12351622 DOI: 10.1074/Jbc.M204915200 |
0.531 |
|
| 2002 |
Xue T, Marbán E, Li RA. Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization. Circulation Research. 90: 1267-73. PMID 12089064 DOI: 10.1161/01.Res.0000024390.97889.C6 |
0.629 |
|
| 2002 |
Ennis IL, Li RA, Murphy AM, Marbán E, Nuss HB. Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility. The Journal of Clinical Investigation. 109: 393-400. PMID 11827999 DOI: 10.1172/JCI13359 |
0.467 |
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| 2002 |
Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marbán E. Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. Febs Letters. 511: 159-64. PMID 11821068 DOI: 10.1016/S0014-5793(01)03316-6 |
0.568 |
|
| 2002 |
Li RA, Ennis IL, Tomaselli GF, Marbán E. Structural basis of differences in isoform-specific gating and lidocaine block between cardiac and skeletal muscle sodium channels. Molecular Pharmacology. 61: 136-41. PMID 11752214 DOI: 10.1124/Mol.61.1.136 |
0.553 |
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