Tamir Gonen, Ph.D. - Publications

Affiliations: 
Howard Hughes Medical Institute, Chevy Chase, MD, United States 
Area:
cryoEM of membrane proteins

80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Nannenga BL, Gonen T. The cryo-EM method microcrystal electron diffraction (MicroED). Nature Methods. 16: 369-379. PMID 31040436 DOI: 10.1038/s41592-019-0395-x  0.52
2018 Purdy MD, Shi D, Chrustowicz J, Hattne J, Gonen T, Yeager M. MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat. Proceedings of the National Academy of Sciences of the United States of America. PMID 30530702 DOI: 10.1073/pnas.1806806115  0.64
2018 Nannenga BL, Gonen T. MicroED: a versatile cryoEM method for structure determination. Emerging Topics in Life Sciences. 2: 1-8. PMID 30167465 DOI: 10.1042/ETLS20170082  0.52
2018 Cao J, Wang G, Gao L, Cheng X, Li S. Organocatalytic reductive coupling of aldehydes with 1,1-diarylethylenes using an generated pyridine-boryl radical. Chemical Science. 9: 3664-3671. PMID 29780496 DOI: 10.1039/c7sc05225a  0.4
2018 Wang Z, Zhang L, Huang P, Gu X, Xie X, Wang Y, Li W, Zeng Q. Weight and the vitamin K expoxide reductase 1 genotype primarily contribute to the warfarin dosing in pediatric patients with Kawasaki disease. Thrombosis Research. 167: 32-36. PMID 29778033 DOI: 10.1016/j.thromres.2018.05.002  0.44
2018 Chen QB, Gao J, Zou GA, Xin XL, Aisa HA. Piperidine Alkaloids with Diverse Skeletons from Anacyclus pyrethrum. Journal of Natural Products. PMID 29775308 DOI: 10.1021/acs.jnatprod.8b00239  0.44
2018 Liu W, Wang Y, Han X, Lu P, Zhu L, Sun C, Qian J, He S. Fluorescence resonance energy transfer (FRET) based nanoparticles composed of AIE luminogens and NIR dyes with enhanced three-photon near-infrared emission for in vivo brain angiography. Nanoscale. PMID 29774924 DOI: 10.1039/c8nr00066b  0.32
2018 Hattne J, Shi D, Glynn C, Zee CT, Gallagher-Jones M, Martynowycz MW, Rodriguez JA, Gonen T. Analysis of Global and Site-Specific Radiation Damage in Cryo-EM. Structure (London, England : 1993). PMID 29706530 DOI: 10.1016/j.str.2018.03.021  0.64
2017 Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Common fibrillar spines of amyloid-β and human Islet Amyloid Polypeptide revealed by Micro Electron Diffraction and inhibitors developed using structure-based design. The Journal of Biological Chemistry. PMID 29282295 DOI: 10.1074/jbc.M117.806109  0.64
2017 de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T. Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nature Methods. PMID 28192420 DOI: 10.1038/nmeth.4178  0.64
2017 Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, et al. Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity. Elife. 6. PMID 28045370 DOI: 10.7554/eLife.19273  0.64
2016 Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. Corrigendum: Design of a hyperstable 60-subunit protein icosahedron. Nature. PMID 27760110 DOI: 10.1038/nature20108  0.64
2016 Nannenga BL, Gonen T. MicroED opens a new era for biological structure determination. Current Opinion in Structural Biology. 40: 128-135. PMID 27701014 DOI: 10.1016/j.sbi.2016.09.007  0.52
2016 Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS. Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proceedings of the National Academy of Sciences of the United States of America. PMID 27647903 DOI: 10.1073/pnas.1606287113  0.64
2016 Shian L, Johan H, Francis RE, Silvia SM, de la Cruz MJ, Shi D, Gonen T. Atomic resolution structure determination by the cryo-EM method MicroED. Protein Science : a Publication of the Protein Society. PMID 27452773 DOI: 10.1002/pro.2989  0.64
2016 Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. Design of a hyperstable 60-subunit protein icosahedron. Nature. PMID 27309817 DOI: 10.1038/nature18010  0.96
2016 Hattne J, Shi D, de la Cruz MJ, Reyes FE, Gonen T. Modeling truncated pixel values of faint reflections in MicroED images. Journal of Applied Crystallography. 49: 1029-1034. PMID 27275145 DOI: 10.1107/S1600576716007196  0.64
2016 Shi D, Nannenga BL, de la Cruz MJ, Liu J, Sawtelle S, Calero G, Reyes FE, Hattne J, Gonen T. The collection of MicroED data for macromolecular crystallography. Nature Protocols. 11: 895-904. PMID 27077331 DOI: 10.1038/nprot.2016.046  0.64
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Gonen T, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/ncomms10882  0.96
2015 Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, ... ... Gonen T, et al. Structure of the toxic core of α-synuclein from invisible crystals. Nature. PMID 26352473 DOI: 10.1038/nature15368  0.96
2015 Bale JB, Park RU, Liu Y, Gonen S, Gonen T, Cascio D, King NP, Yeates TO, Baker D. Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression. Protein Science : a Publication of the Protein Society. PMID 26174163 DOI: 10.1002/pro.2748  0.96
2015 Hattne J, Reyes FE, Nannenga BL, Shi D, de la Cruz MJ, Leslie AG, Gonen T. MicroED data collection and processing. Acta Crystallographica. Section a, Foundations and Advances. 71: 353-360. PMID 26131894 DOI: 10.1107/S2053273315010669  0.96
2015 Gonen S, DiMaio F, Gonen T, Baker D. PROTEIN DESIGN. Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces. Science (New York, N.Y.). 348: 1365-8. PMID 26089516 DOI: 10.1126/science.aaa9897  0.96
2014 Huang PS, Oberdorfer G, Xu C, Pei XY, Nannenga BL, Rogers JM, DiMaio F, Gonen T, Luisi B, Baker D. High thermodynamic stability of parametrically designed helical bundles. Science (New York, N.Y.). 346: 481-5. PMID 25342806 DOI: 10.1126/science.1257481  0.96
2014 Nannenga BL, Shi D, Hattne J, Reyes FE, Gonen T. Structure of catalase determined by MicroED. Elife. 3: e03600. PMID 25303172 DOI: 10.7554/eLife.03600  0.64
2014 Gonen T, Waksman G. Editorial overview: Membranes: recent methods in the study of membrane protein structure. Current Opinion in Structural Biology. 27: iv-v. PMID 25242735 DOI: 10.1016/j.sbi.2014.09.002  0.96
2014 Wisedchaisri G, Park MS, Iadanza MG, Zheng H, Gonen T. Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE. Nature Communications. 5: 4521. PMID 25088546 DOI: 10.1038/ncomms5521  0.96
2014 Nannenga BL, Shi D, Leslie AG, Gonen T. High-resolution structure determination by continuous-rotation data collection in MicroED. Nature Methods. 11: 927-30. PMID 25086503 DOI: 10.1038/nmeth.3043  0.64
2014 Russell AB, Wexler AG, Harding BN, Whitney JC, Bohn AJ, Goo YA, Tran BQ, Barry NA, Zheng H, Peterson SB, Chou S, Gonen T, Goodlett DR, Goodman AL, Mougous JD. A type VI secretion-related pathway in Bacteroidetes mediates interbacterial antagonism. Cell Host & Microbe. 16: 227-36. PMID 25070807 DOI: 10.1016/j.chom.2014.07.007  0.96
2014 Iadanza MG, Gonen T. A suite of software for processing MicroED data of extremely small protein crystals. Journal of Applied Crystallography. 47: 1140-1145. PMID 24904248 DOI: 10.1107/S1600576714008073  0.96
2014 King NP, Bale JB, Sheffler W, McNamara DE, Gonen S, Gonen T, Yeates TO, Baker D. Accurate design of co-assembling multi-component protein nanomaterials. Nature. 510: 103-8. PMID 24870237 DOI: 10.1038/nature13404  0.96
2014 Nannenga BL, Gonen T. Protein structure determination by MicroED. Current Opinion in Structural Biology. 27: 24-31. PMID 24709395 DOI: 10.1016/j.sbi.2014.03.004  0.96
2014 Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD. Amphotericin forms an extramembranous and fungicidal sterol sponge. Nature Chemical Biology. 10: 400-6. PMID 24681535 DOI: 10.1038/nchembio.1496  0.96
2013 Shi D, Nannenga BL, Iadanza MG, Gonen T. Three-dimensional electron crystallography of protein microcrystals. Elife. 2: e01345. PMID 24252878 DOI: 10.7554/eLife.01345  0.96
2013 Smith FD, Reichow SL, Esseltine JL, Shi D, Langeberg LK, Scott JD, Gonen T. Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation. Elife. 2: e01319. PMID 24192038 DOI: 10.7554/eLife.01319  0.96
2013 Gold MG, Gonen T, Scott JD. Local cAMP signaling in disease at a glance. Journal of Cell Science. 126: 4537-43. PMID 24124191 DOI: 10.1242/jcs.133751  0.96
2013 Silverman JM, Agnello DM, Zheng H, Andrews BT, Li M, Catalano CE, Gonen T, Mougous JD. Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates. Molecular Cell. 51: 584-93. PMID 23954347 DOI: 10.1016/j.molcel.2013.07.025  0.96
2013 Reichow SL, Clemens DM, Freites JA, Németh-Cahalan KL, Heyden M, Tobias DJ, Hall JE, Gonen T. Allosteric mechanism of water-channel gating by Ca2+-calmodulin. Nature Structural & Molecular Biology. 20: 1085-92. PMID 23893133 DOI: 10.1038/nsmb.2630  0.96
2013 Zheng H, Wisedchaisri G, Gonen T. Crystal structure of a nitrate/nitrite exchanger. Nature. 497: 647-51. PMID 23665960 DOI: 10.1038/nature12139  0.96
2013 Nannenga BL, Iadanza MG, Vollmar BS, Gonen T. Overview of electron crystallography of membrane proteins: crystallization and screening strategies using negative stain electron microscopy. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit17.15. PMID 23546618 DOI: 10.1002/0471140864.ps1715s72  0.96
2013 Shi L, Zheng H, Zheng H, Borkowski BA, Shi D, Gonen T, Jiang QX. Retraction for Shi et al., "Voltage sensor ring in a native structure of a membrane-embedded potassium channel". Proceedings of the National Academy of Sciences of the United States of America. 110: 7097. PMID 23530252 DOI: 10.1073/pnas.1304582110  0.96
2013 Shi L, Zheng H, Zheng H, Borkowski BA, Shi D, Gonen T, Jiang QX. Voltage sensor ring in a native structure of a membrane-embedded potassium channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 3369-74. PMID 23401554 DOI: 10.1073/pnas.1218203110  0.96
2013 Filbin ME, Vollmar BS, Shi D, Gonen T, Kieft JS. HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. Nature Structural & Molecular Biology. 20: 150-8. PMID 23262488 DOI: 10.1038/nsmb.2465  0.96
2013 Stokes DL, Ubarretxena-Belandia I, Gonen T, Engel A. High-throughput methods for electron crystallography. Methods in Molecular Biology (Clifton, N.J.). 955: 273-96. PMID 23132066 DOI: 10.1007/978-1-62703-176-9_15  0.96
2013 Wisedchaisri G, Gonen T. Phasing electron diffraction data by molecular replacement: strategy for structure determination and refinement. Methods in Molecular Biology (Clifton, N.J.). 955: 243-72. PMID 23132065 DOI: 10.1007/978-1-62703-176-9_14  0.96
2013 Gonen T. The collection of high-resolution electron diffraction data. Methods in Molecular Biology (Clifton, N.J.). 955: 153-69. PMID 23132060 DOI: 10.1007/978-1-62703-176-9_9  0.96
2012 Umbreit NT, Gestaut DR, Tien JF, Vollmar BS, Gonen T, Asbury CL, Davis TN. The Ndc80 kinetochore complex directly modulates microtubule dynamics. Proceedings of the National Academy of Sciences of the United States of America. 109: 16113-8. PMID 22908300 DOI: 10.1073/pnas.1209615109  0.52
2012 Gonen S, Akiyoshi B, Iadanza MG, Shi D, Duggan N, Biggins S, Gonen T. The structure of purified kinetochores reveals multiple microtubule-attachment sites. Nature Structural & Molecular Biology. 19: 925-9. PMID 22885327 DOI: 10.1038/nsmb.2358  0.96
2012 Gonen T, Waksman G. Recent progress in membrane protein structures and investigation methods. Current Opinion in Structural Biology. 22: 467-8. PMID 22819667 DOI: 10.1016/j.sbi.2012.07.002  0.96
2012 King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, André I, Gonen T, Yeates TO, Baker D. Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science (New York, N.Y.). 336: 1171-4. PMID 22654060 DOI: 10.1126/science.1219364  0.96
2012 Jiang QX, Gonen T. The influence of lipids on voltage-gated ion channels. Current Opinion in Structural Biology. 22: 529-36. PMID 22483432 DOI: 10.1016/j.sbi.2012.03.009  0.96
2012 Lo SY, Brett CL, Plemel RL, Vignali M, Fields S, Gonen T, Merz AJ. Intrinsic tethering activity of endosomal Rab proteins. Nature Structural & Molecular Biology. 19: 40-7. PMID 22157956 DOI: 10.1038/nsmb.2162  0.96
2012 Gold MG, Reichow SL, O'Neill SE, Weisbrod CR, Langeberg LK, Bruce JE, Gonen T, Scott JD. AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency. Embo Molecular Medicine. 4: 15-26. PMID 22095752 DOI: 10.1002/emmm.201100184  0.96
2011 Wisedchaisri G, Reichow SL, Gonen T. Advances in structural and functional analysis of membrane proteins by electron crystallography. Structure (London, England : 1993). 19: 1381-93. PMID 22000511 DOI: 10.1016/j.str.2011.09.001  0.96
2011 Wisedchaisri G, Gonen T. Fragment-based phase extension for three-dimensional structure determination of membrane proteins by electron crystallography. Structure (London, England : 1993). 19: 976-87. PMID 21742264 DOI: 10.1016/j.str.2011.04.008  0.96
2011 Budzinski KL, Sgro AE, Fujimoto BS, Gadd JC, Shuart NG, Gonen T, Bajjaleih SM, Chiu DT. Synaptosomes as a platform for loading nanoparticles into synaptic vesicles. Acs Chemical Neuroscience. 2: 236-241. PMID 21666849 DOI: 10.1021/cn200009n  0.44
2011 Korotkov KV, Gonen T, Hol WG. Secretins: dynamic channels for protein transport across membranes. Trends in Biochemical Sciences. 36: 433-43. PMID 21565514 DOI: 10.1016/j.tibs.2011.04.002  0.96
2011 Jehle S, Vollmar BS, Bardiaux B, Dove KK, Rajagopal P, Gonen T, Oschkinat H, Klevit RE. N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity. Proceedings of the National Academy of Sciences of the United States of America. 108: 6409-14. PMID 21464278 DOI: 10.1073/pnas.1014656108  0.96
2011 Reichow SL, Korotkov KV, Gonen M, Sun J, Delarosa JR, Hol WG, Gonen T. The binding of cholera toxin to the periplasmic vestibule of the type II secretion channel. Channels (Austin, Tex.). 5: 215-8. PMID 21406971  0.96
2010 Wisedchaisri G, Dranow DM, Lie TJ, Bonanno JB, Patskovsky Y, Ozyurt SA, Sauder JM, Almo SC, Wasserman SR, Burley SK, Leigh JA, Gonen T. Structural underpinnings of nitrogen regulation by the prototypical nitrogen-responsive transcriptional factor NrpR. Structure (London, England : 1993). 18: 1512-21. PMID 21070950 DOI: 10.1016/j.str.2010.08.014  0.96
2010 Reichow SL, Korotkov KV, Hol WG, Gonen T. Structure of the cholera toxin secretion channel in its closed state. Nature Structural & Molecular Biology. 17: 1226-32. PMID 20852644 DOI: 10.1038/nsmb.1910  0.96
2010 Hall Sedlak R, Hnilova M, Gachelet E, Przybyla L, Dranow D, Gonen T, Sarikaya M, Tamerler C, Traxler B. An engineered DNA-binding protein self-assembles metallic nanostructures. Chembiochem : a European Journal of Chemical Biology. 11: 2108-12. PMID 20827792 DOI: 10.1002/cbic.201000407  0.96
2010 Sanowar S, Singh P, Pfuetzner RA, André I, Zheng H, Spreter T, Strynadka NC, Gonen T, Baker D, Goodlett DR, Miller SI. Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system. Mbio. 1. PMID 20824104 DOI: 10.1128/mBio.00158-10  0.96
2010 Zheng H, Taraska J, Merz AJ, Gonen T. The prototypical H+/galactose symporter GalP assembles into functional trimers. Journal of Molecular Biology. 396: 593-601. PMID 20006622 DOI: 10.1016/j.jmb.2009.12.010  0.96
2009 Reichow SL, Gonen T. Lipid-protein interactions probed by electron crystallography. Current Opinion in Structural Biology. 19: 560-5. PMID 19679462 DOI: 10.1016/j.sbi.2009.07.012  0.96
2008 Reichow SL, Gonen T. Noncanonical binding of calmodulin to aquaporin-0: implications for channel regulation. Structure (London, England : 1993). 16: 1389-98. PMID 18786401 DOI: 10.1016/j.str.2008.06.011  0.96
2008 Andrews S, Reichow SL, Gonen T. Electron crystallography of aquaporins. Iubmb Life. 60: 430-6. PMID 18465794 DOI: 10.1002/iub.53  0.96
2008 Zheng H, Olia AS, Gonen M, Andrews S, Cingolani G, Gonen T. A conformational switch in bacteriophage p22 portal protein primes genome injection. Molecular Cell. 29: 376-83. PMID 18280242 DOI: 10.1016/j.molcel.2007.11.034  0.96
2008 Engel A, Fujiyoshi Y, Gonen T, Walz T. Junction-forming aquaporins. Current Opinion in Structural Biology. 18: 229-35. PMID 18194855 DOI: 10.1016/j.sbi.2007.11.003  0.96
2008 Gonen T, Hite RK, Cheng Y, Petre BM, Kistler J, Walz T. Polymorphic assemblies and crystalline arrays of lens tetraspanin MP20. Journal of Molecular Biology. 376: 380-92. PMID 18166196 DOI: 10.1016/j.jmb.2007.09.001  0.96
2008 Hite RK, Gonen T, Harrison SC, Walz T. Interactions of lipids with aquaporin-0 and other membrane proteins. PflüGers Archiv : European Journal of Physiology. 456: 651-61. PMID 17932686 DOI: 10.1007/s00424-007-0353-9  0.96
2008 Zheng H, Wisedchaisri G, Gonen T. Single particle electron cryomicroscopy of bacteriophage P22 portal protein complexes Microscopy and Microanalysis. 14: 1572-1573. DOI: 10.1017/S1431927608088661  0.96
2007 Viadiu H, Gonen T, Walz T. Projection map of aquaporin-9 at 7 A resolution. Journal of Molecular Biology. 367: 80-8. PMID 17239399 DOI: 10.1016/j.jmb.2006.12.042  0.96
2006 Gonen T, Walz T. The structure of aquaporins. Quarterly Reviews of Biophysics. 39: 361-96. PMID 17156589 DOI: 10.1017/S0033583506004458  0.96
2005 Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 438: 633-8. PMID 16319884 DOI: 10.1038/nature04321  0.96
2004 Gonen T, Cheng Y, Kistler J, Walz T. Aquaporin-0 membrane junctions form upon proteolytic cleavage. Journal of Molecular Biology. 342: 1337-45. PMID 15351655 DOI: 10.1016/j.jmb.2004.07.076  0.96
2004 Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 429: 193-7. PMID 15141214 DOI: 10.1038/nature02503  0.96
2003 Grey AC, Jacobs MD, Gonen T, Kistler J, Donaldson PJ. Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier. Experimental Eye Research. 77: 567-74. PMID 14550398 DOI: 10.1016/S0014-4835(03)00192-1  0.96
2001 Gonen T, Grey AC, Jacobs MD, Donaldson PJ, Kistler J. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. Bmc Cell Biology. 2: 17. PMID 11532191 DOI: 10.1186/1471-2121-2-17  0.96
2000 Gonen T, Donaldson P, Kistler J. Galectin-3 is associated with the plasma membrane of lens fiber cells. Investigative Ophthalmology & Visual Science. 41: 199-203. PMID 10634621  0.96
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