| Year |
Citation |
Score |
| 2020 |
Johnson K, Yin J, In JG, Kulkarni S, Pasricha P, Tse M, Donowitz M. Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways. American Journal of Physiology. Cell Physiology. PMID 32551856 DOI: 10.1152/Ajpcell.00179.2020 |
0.308 |
|
| 2020 |
Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M. Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic infection. Gut Microbes. 1-12. PMID 32378997 DOI: 10.1080/19490976.2020.1752125 |
0.313 |
|
| 2020 |
Kasendra M, Luc R, Yin J, Manatakis DV, Kulkarni G, Lucchesi C, Sliz J, Apostolou A, Sunuwar L, Obrigewitch J, Jang KJ, Hamilton GA, Donowitz M, Karalis K. Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model. Elife. 9. PMID 31933478 DOI: 10.7554/Elife.50135 |
0.305 |
|
| 2020 |
Sarker R, Yang H, Singh V, Lin R, Tse M, Donowitz M. Sa1089 SLC26A3 (DRA) IS STIMULATED BY BOTH CAMP AND CA2+ SIGNALING AND THE EFFECT IS SYNERGISTIC IN INTESTINAL EPITHELIAL CELLS BY A PROCESS THAT REQUIRES IRBIT. Gastroenterology. 158: S-272. DOI: 10.1016/S0016-5085(20)31364-0 |
0.334 |
|
| 2019 |
Sunuwar L, Yin J, Kasendra M, Karalis K, Kaper J, Fleckenstein J, Donowitz M. MECHANICAL STIMULI AFFECT HEAT STABLE ENTEROTOXIN (ST)-CYCLIC GMP SIGNALING IN A HUMAN ENTEROID INTESTINE-CHIP MODEL. Infection and Immunity. PMID 31818966 DOI: 10.1128/Iai.00866-19 |
0.305 |
|
| 2019 |
Blutt SE, Klein OD, Donowitz M, Shroyer NF, Guha C, Estes MK. Use of organoids to study regenerative responses to intestinal damage. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31589468 DOI: 10.1152/Ajpgi.00346.2018 |
0.315 |
|
| 2019 |
Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M. NHERF3 is Necessary for E. coli Heat Stable Enterotoxin (ST)-induced Inhibition of NHE3 - Differences in Signaling in Mouse Small Intestine and Caco-2 Cells. American Journal of Physiology. Cell Physiology. PMID 31365292 DOI: 10.1152/Ajpcell.00351.2018 |
0.403 |
|
| 2019 |
Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901166R. PMID 31268738 DOI: 10.1096/Fj.201901166R |
0.349 |
|
| 2019 |
Melia JMP, Lin R, Xavier RJ, Thompson RB, Fu D, Wan F, Sears CL, Donowitz M. Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease. Biochemical and Biophysical Research Communications. PMID 31151823 DOI: 10.1016/J.Bbrc.2019.05.137 |
0.329 |
|
| 2019 |
Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M. cAMP stimulates SLC26A3 activity in human colon by a CFTR-dependent mechanism that does not require CFTR activity. Cellular and Molecular Gastroenterology and Hepatology. PMID 30659943 DOI: 10.1016/J.Jcmgh.2019.01.002 |
0.398 |
|
| 2018 |
Tse CM, In JG, Yin J, Donowitz M, Doucet M, Foulke-Abel J, Ruiz-Perez F, Nataro JP, Zachos NC, Kaper JB, Kovbasnjuk O. Enterohemorrhagic (EHEC)-Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers. Toxins. 10. PMID 30200426 DOI: 10.3390/Toxins10090351 |
0.384 |
|
| 2018 |
King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, ... ... Donowitz M, et al. Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. Science Translational Medicine. 10. PMID 30158152 DOI: 10.1126/Scitranslmed.Aam6474 |
0.373 |
|
| 2018 |
Yin J, Tse CM, Avula LR, Singh V, Foulke-Abel J, de Jonge HR, Donowitz M. Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. Cellular and Molecular Gastroenterology and Hepatology. 5: 591-609. PMID 29930980 DOI: 10.1016/J.Jcmgh.2018.02.002 |
0.345 |
|
| 2018 |
Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Reports. 22: 1003-1015. PMID 29386123 DOI: 10.1016/J.Celrep.2017.12.093 |
0.31 |
|
| 2018 |
Tse M, Singh V, Yin J, Sarker R, Cha B, In J, Doucet M, Kovbasnjuk O, Donowitz M. 788 - Cholera Toxin (CTX)/Forskolin (FSK) Stimulate Dra (SLC26A3) Related HCO 3 Secretion which Involves Apical Trafficking of Dra in Ileal and Proximal Colonic Enteroid Monolayers and CACO-2 Cells Gastroenterology. 154: S-164. DOI: 10.1016/S0016-5085(18)30959-4 |
0.356 |
|
| 2018 |
Tse M, In J, Doucet M, Yin J, Foulke-Abel JD, Ruiz-Perez F, Nataro J, Zachos NC, Kaper J, Donowitz M, Kovbasnjuk O. 756 - Enterohemorrhagic E. Coli (EHEC) Secreted Serine Protease Espp, Stimulates Active Electrogenic Ion Transport in Human Colonoid Monolayers Gastroenterology. 154: S-160. DOI: 10.1016/S0016-5085(18)30946-6 |
0.317 |
|
| 2017 |
Rajkumar P, Cha B, Yin J, Arend LJ, Păunescu TG, Hirabayashi Y, Donowitz M, Pluznick JL. Identifying the localization and exploring a functional role for Gprc5c in the kidney. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29196502 DOI: 10.1096/Fj.201700610Rr |
0.319 |
|
| 2017 |
Avula LR, Chen T, Kovbasnjuk O, Donowitz M. Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca(2+), cGMP and lysophosphatidic acid. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00140.2017. PMID 28882822 DOI: 10.1152/Ajpgi.00140.2017 |
0.429 |
|
| 2017 |
Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK. Gastrointestinal microphysiological systems. Experimental Biology and Medicine (Maywood, N.J.). 1535370217710638. PMID 28534432 DOI: 10.1177/1535370217710638 |
0.304 |
|
| 2017 |
Yin J, Tse CM, Cha B, Sarker R, Zhu XC, Walentinsson A, Greasley PJ, Donowitz M. A Common NHE3 Single Nucleotide Polymorphism Has Normal Function and Sensitivity to Regulatory Ligands. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00044.2017. PMID 28495802 DOI: 10.1152/Ajpgi.00044.2017 |
0.309 |
|
| 2017 |
Sarker R, Cha B, Kovbasnjuk O, Cole R, Gabelli S, Tse CM, Donowitz M. Phosphorylation of NHE3-S(719) Regulates NHE3 Activity through the Formation of Multiple Signaling Complexes. Molecular Biology of the Cell. PMID 28495796 DOI: 10.1091/Mbc.E16-12-0862 |
0.417 |
|
| 2017 |
Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC. A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions. Scientific Reports. 7: 45270. PMID 28345602 DOI: 10.1016/S0016-5085(17)30545-0 |
0.305 |
|
| 2017 |
Cha B, Yang J, Singh V, Zachos NC, Sarker RI, Chen TE, Chakraborty M, Tse CM, Donowitz M. PDZ Domain Dependent Regulation of NHE3 Occurs by Both Internal Class II and C-terminal Class I PDZ Binding Motifs. The Journal of Biological Chemistry. PMID 28283572 DOI: 10.1074/Jbc.M116.774489 |
0.315 |
|
| 2017 |
Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M. The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annual Review of Physiology. 79: 291-312. PMID 28192061 DOI: 10.1146/Annurev-Physiol-021115-105211 |
0.335 |
|
| 2017 |
Sunuwar L, Asraf H, Donowitz M, Sekler I, Hershfinkel M. The Zn(2+)-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl(-) absorption, via basolateral KCC1, and reduces fluid loss. Biochimica Et Biophysica Acta. PMID 28093242 DOI: 10.1016/J.Bbadis.2017.01.009 |
0.347 |
|
| 2017 |
Melia JP, Xavier R, Sears CL, Donowitz M. The Zinc Transporter ZIP8 is Induced by Inflammatory Stimuli on the Apical Membrane of Intestinal Epithelial Cells: Potential Role in Interactions with the Microbiota in Crohn's Disease Gastroenterology. 152: S984. DOI: 10.1016/S0016-5085(17)33333-4 |
0.363 |
|
| 2017 |
Singh V, Yang J, Yin J, Tse M, Zachos NC, Berman DE, Petsko G, Donowitz M. Cholera Toxin Destabilizes Retromer to Inhibit NA + /H + Exchanger3 Activity in Intestinal Epithelial Cells- Possible Therapeutic Role of a Retromer Stabilizer in Treating Diarrhea Gastroenterology. 152: S67. DOI: 10.1016/S0016-5085(17)30577-2 |
0.414 |
|
| 2016 |
Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for anti-secretory therapy of diarrheas caused by bacterial enterotoxins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27871064 DOI: 10.1096/Fj.201600891R |
0.306 |
|
| 2016 |
Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJ, Donowitz M, Kurth MJ, Verkman AS. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 27815136 DOI: 10.1016/J.Trsl.2016.10.003 |
0.328 |
|
| 2016 |
In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M. Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nature Reviews. Gastroenterology & Hepatology. PMID 27677718 DOI: 10.1038/Nrgastro.2016.142 |
0.346 |
|
| 2016 |
Rehman S, Kekuda R, Tse M, Donowitz M, Rajendran VM. Su1199 Post-Transcriptional Regulation of Na-H Exchanger-3 (NHE3) by Aldosterone Involves microRNA-204 Gastroenterology. 150: S493. DOI: 10.1016/S0016-5085(16)31698-5 |
0.37 |
|
| 2016 |
Foulke-Abel J, In J, Tse M, Zachos NC, Donowitz M, Kovbasnjuk O. Sa1413 Enterohemorrhagic E. coli (EHEC)-Secreted Serine Protease EspP is an Enterotoxin and Stimulates Anion Secretion in Human Stem Cell Derived Colonoid Monolayers Gastroenterology. 150: S309. DOI: 10.1016/S0016-5085(16)31082-4 |
0.303 |
|
| 2016 |
Baetz NW, Gupta A, Kapoor A, Kovbasnjuk O, Turner J, Donowitz M, Estes M, Zachos NC. 541 Rotavirus Infection in Patients Is Associated With Altered Trafficking of Apical Membrane Transport Proteins Gastroenterology. 150: S113-S114. DOI: 10.1016/S0016-5085(16)30487-5 |
0.33 |
|
| 2015 |
Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. PMID 26677983 DOI: 10.1053/J.Gastro.2015.11.047 |
0.352 |
|
| 2015 |
Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, De Jonge HR, Estes MK, Donowitz M. Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. The Journal of Biological Chemistry. PMID 26677228 DOI: 10.1074/Jbc.R114.635995 |
0.318 |
|
| 2015 |
Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar U, Sastri NP, Conner ME, Opekun A, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, ... ... Donowitz M, et al. Human Intestinal Enteroids: A New Model to Study Human Rotavirus Infection, Host Restriction and Pathophysiology. Journal of Virology. PMID 26446608 DOI: 10.1128/Jvi.01930-15 |
0.318 |
|
| 2015 |
Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, ... ... Donowitz M, et al. Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea. Human Molecular Genetics. PMID 26358773 DOI: 10.1093/Hmg/Ddv367 |
0.336 |
|
| 2015 |
Yang J, Sarker R, Singh V, Sarker P, Yin J, Chen TE, Chaerkady R, Li X, Tse CM, Donowitz M. The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity. The Biochemical Journal. 470: 77-90. PMID 26251448 DOI: 10.1042/Bj20150238 |
0.416 |
|
| 2015 |
Thiagarajah JR, Donowitz M, Verkman AS. Secretory diarrhoea: mechanisms and emerging therapies. Nature Reviews. Gastroenterology & Hepatology. 12: 446-57. PMID 26122478 DOI: 10.1038/Nrgastro.2015.111 |
0.373 |
|
| 2015 |
Singh V, Yang J, Cha B, Chen TE, Sarker R, Yin J, Avula LR, Tse M, Donowitz M. Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3. Molecular Biology of the Cell. 26: 2030-43. PMID 25851603 DOI: 10.1091/Mbc.E14-12-1597 |
0.39 |
|
| 2015 |
Zhu XC, Sarker R, Horton JR, Chakraborty M, Chen TE, Tse CM, Cha B, Donowitz M. Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity. American Journal of Physiology. Cell Physiology. 308: C758-66. PMID 25715704 DOI: 10.1152/Ajpcell.00421.2014 |
0.361 |
|
| 2015 |
Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R, Donowitz M. Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site. The Journal of Biological Chemistry. 290: 1952-65. PMID 25480791 DOI: 10.1074/Jbc.M114.590174 |
0.358 |
|
| 2015 |
Yang J, Sarker R, Singh V, Sarker P, Yin J, Chen TE, Chaerkady R, Li X, Tse CM, Donowitz M. The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity Biochemical Journal. 470: 77-90. DOI: 10.1042/BJ20150238 |
0.301 |
|
| 2015 |
Biswas RS, Wang P, Kovbasnjuk O, Donowitz M, Estes MK, Zachos NC. Tu1401 Differential Intracellular Calcium Inhibition of NHE3 Activity Gastroenterology. 148: S-880. DOI: 10.1016/S0016-5085(15)32988-7 |
0.387 |
|
| 2015 |
Foulke-Abel J, In J, Zachos NC, Kovbasnjuk O, Donowitz M. 27 Neutral Na+ Absorption and Fluid/Anion Secretion Are Not Separated Processes in the Human Enteroid Model Gastroenterology. 148: S-9. DOI: 10.1016/S0016-5085(15)30027-5 |
0.323 |
|
| 2014 |
Li X, Donowitz M. Fractionation of subcellular membrane vesicles of epithelial and non-epithelial cells by OptiPrepâ„¢ density gradient ultracentrifugation. Methods in Molecular Biology (Clifton, N.J.). 1174: 85-99. PMID 24947376 DOI: 10.1007/978-1-4939-0944-5_6 |
0.317 |
|
| 2014 |
Chen T, Hubbard A, Murtazina R, Price J, Yang J, Cha B, Sarker R, Donowitz M. Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells. Journal of Cell Science. 127: 3535-45. PMID 24928903 DOI: 10.1242/Jcs.149930 |
0.393 |
|
| 2014 |
Yang J, Singh V, Chen TE, Sarker R, Xiong L, Cha B, Jin S, Li X, Tse CM, Zachos NC, Donowitz M. NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol. The Journal of Biological Chemistry. 289: 20039-53. PMID 24867958 DOI: 10.1074/Jbc.M114.562413 |
0.419 |
|
| 2014 |
Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M. Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling. American Journal of Physiology. Cell Physiology. 307: C55-65. PMID 24760985 DOI: 10.1152/Ajpcell.00045.2014 |
0.431 |
|
| 2014 |
Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Experimental Biology and Medicine (Maywood, N.J.). 239: 1124-34. PMID 24719375 DOI: 10.1177/1535370214529398 |
0.33 |
|
| 2014 |
Singh V, Lin R, Yang J, Cha B, Sarker R, Tse CM, Donowitz M. AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking. The Journal of Biological Chemistry. 289: 5449-61. PMID 24398676 DOI: 10.1074/Jbc.M113.521336 |
0.371 |
|
| 2014 |
Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS. Discovery and development of antisecretory drugs for treating diarrheal diseases. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 12: 204-9. PMID 24316107 DOI: 10.1016/J.Cgh.2013.12.001 |
0.315 |
|
| 2014 |
Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 12: 27-31. PMID 24184676 DOI: 10.1016/J.Cgh.2013.10.020 |
0.35 |
|
| 2014 |
Mroz MS, Keating N, Ward JB, Sarker R, Amu S, Aviello G, Donowitz M, Fallon PG, Keely SJ. Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo. Gut. 63: 808-17. PMID 23916961 DOI: 10.1136/Gutjnl-2013-305088 |
0.416 |
|
| 2014 |
Luo M, Liu Y, Riederer B, Patrucco E, Hofmann F, Donowitz M, Tian D, Yun C, de Jonge H, Lamprecht G, Seidler U. Mo1751 CGMP-Dependent Kinase 2, Na+/H+ Regulatory Factor 2, and Na+/H+ Exchanger Isoform 3 Dynamically Assemble Within Lipid Rafts in Murine Small Intestinal Brush Border Membrane Gastroenterology. 146: S-651-S-652. DOI: 10.1016/S0016-5085(14)62368-4 |
0.406 |
|
| 2014 |
Yang J, Singh V, Chen T, Sarker R, Cha B, Zachos NC, Donowitz M. Mo1747 NHERF2/NHERF3 Hetero-Dimerization Is Required for Carbachol Inhibition of NHE3 Activity That Involves Formation of NHE3 Macro-Complexes Gastroenterology. 146: S-651. DOI: 10.1016/S0016-5085(14)62364-7 |
0.368 |
|
| 2014 |
Foulke-Abel J, In J, Zachos NC, Kovbasnjuk O, Ettayebi K, de Jonge H, Estes MK, Donowitz M. 190 Human Small Intestinal Enteroids Enable Mechanistic Studies of cAMPInduced Changes in Intracellular pH Gastroenterology. 146: S-50. DOI: 10.1016/S0016-5085(14)60173-6 |
0.314 |
|
| 2014 |
Singh V, Yang J, Sarker R, Chen T, Cha B, Zachos NC, Donowitz M. 189 Basal and Stimulated BB NHE3 Activity Requires Intracellular SNX27, a PDZDomain Containing Binding Partner of NHE3 That Regulates Endosome to Plasma Membrane Trafficking Gastroenterology. 146: S-50. DOI: 10.1016/S0016-5085(14)60172-4 |
0.354 |
|
| 2013 |
Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M. Human enteroids: preclinical models of non-inflammatory diarrhea. Stem Cell Research & Therapy. 4: S3. PMID 24564938 DOI: 10.1186/Scrt364 |
0.339 |
|
| 2013 |
Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, Lissner S, Gessner JE, Donowitz M, Yun CC, deJonge H, Lamprecht G, Seidler U. Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 32: 1386-402. PMID 24297041 DOI: 10.1159/000356577 |
0.388 |
|
| 2013 |
Zachos NC, Lee LJ, Kovbasnjuk O, Li X, Donowitz M. PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells. American Journal of Physiology. Cell Physiology. 305: C266-75. PMID 23703528 DOI: 10.1152/Ajpcell.00277.2012 |
0.358 |
|
| 2013 |
Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M. NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells. The Journal of Biological Chemistry. 288: 16960-74. PMID 23612977 DOI: 10.1074/Jbc.M113.470799 |
0.381 |
|
| 2013 |
Lee HW, Cheng J, Kovbasnjuk O, Donowitz M, Guggino WB. Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR. Plos One. 8: e59992. PMID 23555857 DOI: 10.1371/Journal.Pone.0059992 |
0.314 |
|
| 2013 |
Donowitz M, Ming Tse C, Fuster D. SLC9/NHE gene family, a plasma membrane and organellar family of Naâº/H⺠exchangers. Molecular Aspects of Medicine. 34: 236-51. PMID 23506868 DOI: 10.1016/J.Mam.2012.05.001 |
0.325 |
|
| 2013 |
Luo M, Sultan A, Yu Q, Riederer B, Xia W, Luo M, Chen M, Lissner S, Gessner E, Patrucco E, Hofmann F, Donowitz M, Yun CC, de Jonge H, Lamprecht G, et al. cGMP-dependent kinase 2, Na+/H+ regulatory factor 2, and Na+/H+ exchanger isoform 3 assemble within lipid rafts in murine small intestinal brush border membrane Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-O31 |
0.423 |
|
| 2013 |
Sarker R, Singh V, Yang J, Murtazina R, Chen T, Cha B, Chakraborty M, Kovbasnjuk O, Li X, Zachos NC, Tse M, Donowitz M. Mo1793 CK2 Phosphorylatoin of NHE3 At S719 Is Necessary for the PI3-K/AKT Component of Basal NHE3 Activity and for Carbachol/Ca2+ but Not cAMP Inhibition-Effects Involving the Lipid Raft Pool of NHE3 Gastroenterology. 144: S-665. DOI: 10.1016/S0016-5085(13)62463-4 |
0.317 |
|
| 2013 |
Kazi MH, Sarker R, Lin Z, Cha B, Donowitz M, Tse M. 728 Zinc Stimulates Intestinal Na/H Exchanger 3 (NHE3) via Trafficking Effects in a Phospholipase C (PLC) Dependent Manner Gastroenterology. 144: S-130. DOI: 10.1016/S0016-5085(13)60468-0 |
0.406 |
|
| 2013 |
Zachos NC, In J, Foulke-Abel J, Middendorp S, de Jonge H, Zeng X, Ettayebi K, Estes MK, Donowitz M, Kovbasnjuk O. 401 Human Ex Vivo Enteroid Culture As a Functional Model of Human Small Intestinal Physiology and Pathophysiology: Inhibition of Na+ Absorption by cAMP and Rotavirus and Stimulation of Cl− Secretion by cAMP Gastroenterology. 144: S-78. DOI: 10.1016/S0016-5085(13)60286-3 |
0.363 |
|
| 2012 |
Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M. Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process. The Journal of Biological Chemistry. 287: 13442-56. PMID 22371496 DOI: 10.1074/Jbc.M111.307256 |
0.624 |
|
| 2012 |
Zachos NC, van Rossum DB, Murtazina R, Chakraborty M, Patterson RL, Donowitz M. 4 A Peptide Mimicking the NHE3 C-Terminus Stimulates Basal and Blocks CA2+ and cAMP Inhibition of NHE3 Activity, and Prevents Cholera Toxin-Induced Mouse Jejunal Fluid Accumulation: Potential Role as Drug Therapy for Diarrhea Gastroenterology. 142: S-1. DOI: 10.1016/S0016-5085(12)60004-3 |
0.308 |
|
| 2011 |
Zhu X, Cha B, Zachos NC, Sarker R, Chakraborty M, Chen TE, Kovbasnjuk O, Donowitz M. Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli. The Journal of Biological Chemistry. 286: 34486-96. PMID 21799002 DOI: 10.1074/Jbc.M111.230219 |
0.386 |
|
| 2011 |
Lin Z, Jin S, Duan X, Wang T, Martini S, Hulamm P, Cha B, Hubbard A, Donowitz M, Guggino SE. Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3). The Journal of Biological Chemistry. 286: 22833-45. PMID 21561868 DOI: 10.1074/Jbc.M111.224998 |
0.366 |
|
| 2011 |
Murtazina R, Kovbasnjuk O, Chen TE, Zachos NC, Chen Y, Kocinsky HS, Hogema BM, Seidler U, de Jonge HR, Donowitz M. NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum. American Journal of Physiology. Cell Physiology. 301: C126-36. PMID 21430287 DOI: 10.1152/Ajpcell.00311.2010 |
0.411 |
|
| 2011 |
Brett CL, Kallay L, Hua Z, Green R, Chyou A, Zhang Y, Graham TR, Donowitz M, Rao R. Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae. Plos One. 6: e17619. PMID 21423800 DOI: 10.1371/Journal.Pone.0017619 |
0.708 |
|
| 2011 |
Grillon E, Farion R, Fablet K, De Waard M, Tse CM, Donowitz M, Rémy C, Coles JA. The spatial organization of proton and lactate transport in a rat brain tumor. Plos One. 6: e17416. PMID 21390324 DOI: 10.1371/Journal.Pone.0017416 |
0.32 |
|
| 2011 |
Sarker R, Valkhoff VE, Zachos NC, Lin R, Cha B, Chen TE, Guggino S, Zizak M, de Jonge H, Hogema B, Donowitz M. NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity. American Journal of Physiology. Cell Physiology. 300: C771-82. PMID 21191106 DOI: 10.1152/Ajpcell.00119.2010 |
0.462 |
|
| 2011 |
Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, Turner JR, Li X, Kovbasnjuk O, Donowitz M. D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process. Gastroenterology. 140: 560-71. PMID 20977906 DOI: 10.1053/J.Gastro.2010.10.042 |
0.418 |
|
| 2011 |
Lukyanenko V, Hubbard A, Delannoy M, Donowitz M, Kovbasnjuk O. Towards understanding mechanisms underlying EHEC-induced transcellular transport of nano-objects across an intestinal epithelial barrier Inflammatory Bowel Diseases. 17: S85. DOI: 10.1097/00054725-201112002-00281 |
0.309 |
|
| 2011 |
Riederer B, Singh AK, Yeruva S, Sultan A, Rausch B, Engelhardt R, Yun C, Kocher O, Donowitz M, Hogema BM, deJonge H, Seidler U. Glucocorticoid-Mediated Increase in NHE3 Synthesis, Membrane Trafficking and Function is Differentially Impaired in NHERF2 Ko and NHERF3 (PDZK1) Ko Ileum Gastroenterology. 140: S-658. DOI: 10.1016/S0016-5085(11)62727-3 |
0.306 |
|
| 2011 |
Cha B, Yang J, Zhang C, Sarker R, Chakraborty M, Zachos NC, Mohan S, Donowitz M. NHE3 Contains Two Cytoskeleton Associated C-Terminal, Ezrin Containing Signaling Complexes, One for Acute Stimulation and One for Inhibition, Which Together Account for Acute NHE3 Regulation Gastroenterology. 140: S-657. DOI: 10.1016/S0016-5085(11)62725-X |
0.539 |
|
| 2011 |
Zachos NC, Lee LJ, Kovbasnjuk O, Li X, Donowitz M. SRC Dynamic Increase in Direct Binding to the PLC-γ SH2 Domain(S), but Not NHE3, is Necessary to Form Signaling Complexes to Allow Carbachol Mediated Inhibition of NHE3 Activity in CACO-2/Bbe Cells Gastroenterology. 140: S-657. DOI: 10.1016/S0016-5085(11)62724-8 |
0.339 |
|
| 2011 |
Zizak M, Sarker R, Chen T, Cha B, Gucek M, Cole RN, Tse MC, Donowitz M. CAM Kinase IIγ Inhibits Activity and Directly Binds the C-Terminal Domain of the Intestinal Brush Border Na/H Exchanger NHE3 in a Dymanic, Ca2+ Dependent Manner Gastroenterology. 140: S-133. DOI: 10.1016/S0016-5085(11)60543-X |
0.406 |
|
| 2010 |
Chen M, Sultan A, Cinar A, Yeruva S, Riederer B, Singh AK, Li J, Bonhagen J, Chen G, Yun C, Donowitz M, Hogema B, de Jonge H, Seidler U. Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine. The Journal of Physiology. 588: 5049-63. PMID 20962002 DOI: 10.1113/Jphysiol.2010.198721 |
0.452 |
|
| 2010 |
Donowitz M, Singh S, Singh P, Salahuddin FF, Chen Y, Chakraborty M, Murtazina R, Gucek M, Cole RN, Zachos NC, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, et al. Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiological Genomics. 42: 200-10. PMID 20736413 DOI: 10.1152/Physiolgenomics.00001.2010 |
0.424 |
|
| 2010 |
Mohan S, Tse CM, Gabelli SB, Sarker R, Cha B, Fahie K, Nadella M, Zachos NC, Tu-Sekine B, Raben D, Amzel LM, Donowitz M. NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region. The Journal of Biological Chemistry. 285: 34566-78. PMID 20736165 DOI: 10.1074/Jbc.M110.165712 |
0.552 |
|
| 2010 |
Cha B, Zhu XC, Chen W, Jones M, Ryoo S, Zachos NC, Chen TE, Lin R, Sarker R, Kenworthy AK, Tse M, Kovbasnjuk O, Donowitz M. NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid. Journal of Cell Science. 123: 2434-43. PMID 20571054 DOI: 10.1242/Jcs.056713 |
0.393 |
|
| 2010 |
Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J, Pollitt RJ, Morgan NV, Tee L, Gissen P, Kahr WH, Knisely AS, Watson S, Chitayat D, Booth IW, Protheroe S, et al. Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy). Gastroenterology. 138: 2388-98, 2398.e1-2. PMID 20176027 DOI: 10.1053/J.Gastro.2010.02.010 |
0.32 |
|
| 2010 |
Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC. Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology. 138: 649-58. PMID 19800338 DOI: 10.1053/J.Gastro.2009.09.055 |
0.404 |
|
| 2010 |
Laiko M, Murtazina R, Malyukova I, Zhu C, Boedeker EC, Gutsal O, O'Malley R, Cole RN, Tarr PI, Murray KF, Kane A, Donowitz M, Kovbasnjuk O. Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3. Experimental Cell Research. 316: 657-66. PMID 19744479 DOI: 10.1016/J.Yexcr.2009.09.002 |
0.387 |
|
| 2010 |
Mohan S, Tse MC, Gabelli SB, Sarker R, Cha B, Zachos NC, Raben D, Amzel M, Donowitz M. T1871 NHE3 Activity is Dependent on Direct Phosphatidylinositide Binding at Its Proximal Cytosolic Region Gastroenterology. 138: S-596. DOI: 10.1016/S0016-5085(10)62749-7 |
0.51 |
|
| 2010 |
Chen M, Cinar A, Yeruva S, Riederer B, Singh AK, Bonhagen J, Donowitz M, Hogema BM, de Jonge H, Seidler U. T1841 Differential Effect of NHE3 Kinase a Regulatory Protein (E3karp/NHERF2) Knockout on cAMP-, cGMP-, or [Ca2+]-Induced Inhibition of Na+/H+ Exchanger 3 (NHE3) Activity Along the Murine Intestinal Tract Gastroenterology. 138: S-590. DOI: 10.1016/S0016-5085(10)62719-9 |
0.366 |
|
| 2010 |
Lin R, Cha B, Chakraborty M, Mohan S, Donowitz M. 1015 A Novel Ser-Rich Motif in the NHE3 C-Terminal Regulatory Domain is Required for Stimulation of Na/H Exchange Activity by AKT as Well as for Direct Ezrin Binding to NHE3 Gastroenterology. 138: S-147. DOI: 10.1016/S0016-5085(10)60674-9 |
0.596 |
|
| 2010 |
Zachos NC, Li X, Lee LJ, Donowitz M. 1014 SRC Dynamically Associates With PLC-γ and is Necessary for CA2+-Mediated Inhibition of NHE3 Activity in CACO-2/BBE Cells Gastroenterology. 138: S-147. DOI: 10.1016/S0016-5085(10)60673-7 |
0.308 |
|
| 2010 |
Cha B, Zhu XC, Zachos NC, Sarker R, Chakraborty M, Kovbasnjuk O, Donowitz M. The NHERF2 Dependent Dynamic Ca2+/LPA Regulation of NHE3 Mobility and Interaction At the Epithelial Brush Border Biophysical Journal. 98: 56a. DOI: 10.1016/J.Bpj.2009.12.319 |
0.38 |
|
| 2009 |
Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M. PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. American Journal of Physiology. Renal Physiology. 297: F1560-5. PMID 19794105 DOI: 10.1152/Ajprenal.90657.2008 |
0.384 |
|
| 2009 |
Zachos NC, Kovbasnjuk O, Donowitz M. Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium. Annals of the New York Academy of Sciences. 1165: 240-8. PMID 19538312 DOI: 10.1111/J.1749-6632.2009.04055.X |
0.392 |
|
| 2009 |
Zachos NC, Li X, Kovbasnjuk O, Hogema B, Sarker R, Lee LJ, Li M, de Jonge H, Donowitz M. NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells. The Journal of Biological Chemistry. 284: 23708-18. PMID 19535329 DOI: 10.1074/Jbc.M109.012641 |
0.368 |
|
| 2009 |
Zachos NC, van Rossum DB, Li X, Caraveo G, Sarker R, Cha B, Mohan S, Desiderio S, Patterson RL, Donowitz M. Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity. The Journal of Biological Chemistry. 284: 19437-44. PMID 19473983 DOI: 10.1074/Jbc.M109.006098 |
0.578 |
|
| 2009 |
Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X. NHE3 regulatory complexes. The Journal of Experimental Biology. 212: 1638-46. PMID 19448074 DOI: 10.1242/Jeb.028605 |
0.603 |
|
| 2009 |
Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. The Journal of Clinical Investigation. 119: 540-50. PMID 19221439 DOI: 10.1172/Jci35541 |
0.345 |
|
| 2009 |
Malyukova I, Murray KF, Zhu C, Boedeker E, Kane A, Patterson K, Peterson JR, Donowitz M, Kovbasnjuk O. Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G78-92. PMID 18974311 DOI: 10.1152/Ajpgi.90347.2008 |
0.362 |
|
| 2009 |
Sullivan S, Alex P, Dassopoulos T, Zachos NC, Iacobuzio-Donahue C, Donowitz M, Brant SR, Cuffari C, Harris ML, Datta LW, Conklin L, Chen Y, Li X. Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea. Inflammatory Bowel Diseases. 15: 261-74. PMID 18942765 DOI: 10.1002/Ibd.20743 |
0.393 |
|
| 2009 |
Broere N, Chen M, Cinar A, Singh AK, Hillesheim J, Riederer B, Lünnemann M, Rottinghaus I, Krabbenhöft A, Engelhardt R, Rausch B, Weinman EJ, Donowitz M, Hubbard A, Kocher O, et al. Defective jejunal and colonic salt absorption and alteredNa(+)/H (+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice. Pflã¼Gers Archiv : European Journal of Physiology. 457: 1079-91. PMID 18758809 DOI: 10.1007/S00424-008-0579-1 |
0.434 |
|
| 2009 |
Chen T, Murtazina R, Tse M, Sarker R, Kovbasnjuk O, Zachos NC, Donowitz M, Li X. T1727 Myosin Vi Is Necessary for Setting Brush Border NHE3 Activity: An Effect On NHE3 Trafficking/Endocytosis Gastroenterology. 136: A-567. DOI: 10.1016/S0016-5085(09)62608-1 |
0.395 |
|
| 2009 |
Zhu XC, Sarker R, Jingjing T, Chen T, Tse M, Booth IW, Brant SR, Donowitz M, Li X. 886 Do Mutations of NHE3 At the Site of Poorly Functioning NHE3 Polymorphisms Contribute to Diarrhea of Congenital Na Diarrhea? Gastroenterology. 136: A-137. DOI: 10.1016/S0016-5085(09)60615-6 |
0.416 |
|
| 2009 |
Malyukova I, Boedeker EC, Donowitz M, Kovbasnjuk O. 551 Shiga Toxin 1 Uptake By Intestinal Epithelial Cells Is CDC-42 Mediated and Clathrin-Independent Gastroenterology. 136: A-86. DOI: 10.1016/S0016-5085(09)60386-3 |
0.392 |
|
| 2008 |
Zachos NC, Hodson C, Kovbasnjuk O, Li X, Thelin WR, Cha B, Milgram S, Donowitz M. Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 22: 693-704. PMID 19088451 DOI: 10.1159/000185553 |
0.383 |
|
| 2008 |
Sarker R, Grønborg M, Cha B, Mohan S, Chen Y, Pandey A, Litchfield D, Donowitz M, Li X. Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3. Molecular Biology of the Cell. 19: 3859-70. PMID 18614797 DOI: 10.1091/Mbc.E08-01-0019 |
0.6 |
|
| 2008 |
Cha B, Donowitz M. The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins. Clinical and Experimental Pharmacology & Physiology. 35: 863-71. PMID 18430067 DOI: 10.1111/J.1440-1681.2008.04931.X |
0.409 |
|
| 2008 |
Maluykova I, Gutsal O, Laiko M, Kane A, Donowitz M, Kovbasnjuk O. Latrunculin B facilitates Shiga toxin 1 transcellular transcytosis across T84 intestinal epithelial cells. Biochimica Et Biophysica Acta. 1782: 370-7. PMID 18342638 DOI: 10.1016/J.Bbadis.2008.01.010 |
0.36 |
|
| 2008 |
Malyukova I, Kane A, Donowitz M, Kovbasnjuk O. W1274 Macropinocytosis Is Involved in Shiga Toxin 1 Uptake and Transcytosis By Gb3-Negative Human Intestinal Epithelial Cells Gastroenterology. 134: A-670. DOI: 10.1016/S0016-5085(08)63125-X |
0.351 |
|
| 2008 |
Zhang C, Cha B, Donowitz M. M1723 Basal Activity of the Epithelial Brush Border Na/H Exchanger NHE3 Is Stimulated By Both PI-3K and AKT-Dependent and Independent Pathways Gastroenterology. 134: A-405. DOI: 10.1016/S0016-5085(08)61893-4 |
0.372 |
|
| 2008 |
Donowitz M, Singh S, Salahuddin FF, Hogema BM, Gucek M, Cole RN, Chen Y, Murtazina R, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring JR, deJonge H, Li X. S1770 Proteome of the Small Intestinal Brush Border of the NHERF1 Knock Out Mouse: Up Regulation of Transporters and Pro-Proliferation Molecules Gastroenterology. 134: A-266. DOI: 10.1016/S0016-5085(08)61238-X |
0.323 |
|
| 2008 |
Murtazina R, Kovbasnjuk O, Chen Y, Hogema BM, Seidler UE, Weinman EJ, de Jonge H, Donowitz M. 749 Nherf2 Is Necessary for Basal and All Second Messenger Regulation of NHE3 Activity in Intact Mouse Ileal Na Absorptive Cells Gastroenterology. 134: A-108. DOI: 10.1016/S0016-5085(08)60508-9 |
0.403 |
|
| 2008 |
Zachos NC, van Rossum DB, Patterson R, Snyder S, Donowitz M. 744 Phospholipase Cγ (PLCγ) Directly Binds to the Na+/H+ Exchanger 3 (NHE3) C-Terminus Which Is Necessary for Basal and Calcium-Mediated Inhibition of NHE3 Activity Gastroenterology. 134: A-107. DOI: 10.1016/S0016-5085(08)60503-X |
0.376 |
|
| 2007 |
Broere N, Hillesheim J, Tuo B, Jorna H, Houtsmuller AB, Shenolikar S, Weinman EJ, Donowitz M, Seidler U, de Jonge HR, Hogema BM. Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. The Journal of Biological Chemistry. 282: 37575-84. PMID 17947234 DOI: 10.1074/Jbc.M704878200 |
0.376 |
|
| 2007 |
Donowitz M, Singh S, Salahuddin FF, Hogema BM, Chen Y, Gucek M, Cole RN, Ham A, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring J, deJonge H, Li X. Proteome of murine jejunal brush border membrane vesicles. Journal of Proteome Research. 6: 4068-79. PMID 17845021 DOI: 10.1021/Pr0701761 |
0.387 |
|
| 2007 |
Donowitz M, Li X. Regulatory binding partners and complexes of NHE3. Physiological Reviews. 87: 825-72. PMID 17615390 DOI: 10.1152/Physrev.00030.2006 |
0.4 |
|
| 2007 |
Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M. Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. The Journal of Biological Chemistry. 282: 25141-51. PMID 17580307 DOI: 10.1074/Jbc.M701910200 |
0.429 |
|
| 2007 |
Kovbasnjuk ON, Malyukova I, Gutsal O, Laiko M, Zhu C, Boedeker E, Gucek M, Cole R, Kane A, Donowitz M. Actin turnover is linked to Shiga toxin 1 transcellular transcytosis across intestinal epithelial cells The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A587-A |
0.331 |
|
| 2006 |
Murtazina R, Kovbasnjuk O, Donowitz M, Li X. Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependent. The Journal of Biological Chemistry. 281: 17845-55. PMID 16648141 DOI: 10.1074/Jbc.M601740200 |
0.435 |
|
| 2006 |
Cha B, Tse M, Yun C, Kovbasnjuk O, Mohan S, Hubbard A, Arpin M, Donowitz M. The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border. Molecular Biology of the Cell. 17: 2661-73. PMID 16540524 DOI: 10.1091/Mbc.E05-09-0843 |
0.58 |
|
| 2006 |
Brett CL, Donowitz M, Rao R. Does the proteome encode organellar pH? Febs Letters. 580: 717-9. PMID 16413548 DOI: 10.1016/J.Febslet.2005.12.103 |
0.694 |
|
| 2006 |
Cinar A, Chen M, Riederer B, Hogema B, de Jonge H, Donowitz M, Weinman E, Kocher O, Seidler U. Differential effects of PDZ-Adapterprotein NHERF1, E3KARP and PDZK1 knockout on the regulation of NHE3 transport activity in native murine colonic epithelium Zeitschrift FüR Gastroenterologie. 44. DOI: 10.1055/S-2006-950687 |
0.35 |
|
| 2005 |
Kovbasnjuk O, Mourtazina R, Baibakov B, Wang T, Elowsky C, Choti MA, Kane A, Donowitz M. The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 102: 19087-92. PMID 16365318 DOI: 10.1073/Pnas.0506474102 |
0.305 |
|
| 2005 |
Wang Y, Cai H, Cebotaru L, Hryciw DH, Weinman EJ, Donowitz M, Guggino SE, Guggino WB. ClC-5: role in endocytosis in the proximal tubule. American Journal of Physiology. Renal Physiology. 289: F850-62. PMID 15942052 DOI: 10.1152/Ajprenal.00011.2005 |
0.342 |
|
| 2005 |
Donowitz M, Cha B, Zachos NC, Brett CL, Sharma A, Tse CM, Li X. NHERF family and NHE3 regulation. The Journal of Physiology. 567: 3-11. PMID 15905209 DOI: 10.1113/Jphysiol.2005.090399 |
0.707 |
|
| 2005 |
Cha B, Kim JH, Hut H, Hogema BM, Nadarja J, Zizak M, Cavet M, Lee-Kwon W, Lohmann SM, Smolenski A, Tse CM, Yun C, de Jonge HR, Donowitz M. cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein. The Journal of Biological Chemistry. 280: 16642-50. PMID 15722341 DOI: 10.1074/Jbc.M500505200 |
0.432 |
|
| 2005 |
Zachos NC, Tse M, Donowitz M. Molecular physiology of intestinal Na+/H+ exchange. Annual Review of Physiology. 67: 411-43. PMID 15709964 DOI: 10.1146/Annurev.Physiol.67.031103.153004 |
0.432 |
|
| 2005 |
Brett CL, Donowitz M, Rao R. Evolutionary origins of eukaryotic sodium/proton exchangers. American Journal of Physiology. Cell Physiology. 288: C223-39. PMID 15643048 DOI: 10.1152/Ajpcell.00360.2004 |
0.738 |
|
| 2004 |
Choi JW, Lee-Kwon W, Jeon ES, Kang YJ, Kawano K, Kim HS, Suh PG, Donowitz M, Kim JH. Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C. Biochimica Et Biophysica Acta. 1683: 59-68. PMID 15238220 DOI: 10.1016/J.Bbalip.2004.04.005 |
0.405 |
|
| 2004 |
Cha B, Kenworthy A, Murtazina R, Donowitz M. The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP. Journal of Cell Science. 117: 3353-65. PMID 15226406 DOI: 10.1242/Jcs.01180 |
0.417 |
|
| 2004 |
Jung Kang Y, Su Jeon E, Jin Lee H, Oh YS, Suh PG, Sup Jung J, Donowitz M, Ho Kim J. NHERF2 increases platelet-derived growth factor-induced proliferation through PI-3-kinase/Akt-, ERK-, and Src family kinase-dependent pathway. Cellular Signalling. 16: 791-800. PMID 15115658 DOI: 10.1016/J.Cellsig.2003.12.003 |
0.327 |
|
| 2004 |
Li X, Zhang H, Cheong A, Leu S, Chen Y, Elowsky CG, Donowitz M. Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent. The Journal of Physiology. 556: 791-804. PMID 14978207 DOI: 10.1113/Jphysiol.2004.060921 |
0.433 |
|
| 2004 |
Li X, Leu S, Cheong A, Zhang H, Baibakov B, Shih C, Birnbaum MJ, Donowitz M. Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation. Gastroenterology. 126: 122-35. PMID 14699494 DOI: 10.1053/J.Gastro.2003.10.061 |
0.4 |
|
| 2003 |
Lee-Kwon W, Kim JH, Choi JW, Kawano K, Cha B, Dartt DA, Zoukhri D, Donowitz M. Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes. American Journal of Physiology. Cell Physiology. 285: C1527-36. PMID 12954600 DOI: 10.1152/Ajpcell.00017.2003 |
0.371 |
|
| 2003 |
Lee-Kwon W, Kawano K, Choi JW, Kim JH, Donowitz M. Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism. The Journal of Biological Chemistry. 278: 16494-501. PMID 12595524 DOI: 10.1074/Jbc.M300580200 |
0.421 |
|
| 2003 |
Cha B, Oh S, Shanmugaratnam J, Donowitz M, Yun CC. Two histidine residues in the juxta-membrane cytoplasmic domain of Na+/H+ exchanger isoform 3 (NHE3) determine the set point. The Journal of Membrane Biology. 191: 49-58. PMID 12532276 DOI: 10.1007/S00232-002-1044-2 |
0.396 |
|
| 2003 |
Jonge H, Hogema B, Hut H, Lohmann S, Smolenski A, Cha B, Donowitz M. Cyclic GMP-dependent protein kinase regulation of epithelial transporters Bmc News and Views. 3. DOI: 10.1186/2048-4623-3-S2-Op005 |
0.361 |
|
| 2003 |
Cha B, Edidin M, Kenworthy AK, Donowitz M. The lateral mobility of NHE3 on the apical membrane of polarized epithelial cells is limited by binding to PDZ domain proteins NHERF1/2 as determined by fluorescence recovery after photobleaching (FRAP) Gastroenterology. 124: A472. DOI: 10.1016/S0016-5085(03)82387-9 |
0.331 |
|
| 2003 |
Zizak M, Bartonicek D, Cha B, Murtazina R, Kim J, Lee-Kwon W, Gorelick F, Tse M, Donowitz M. Calcium/calmodulin dependent protein kinase II constitutively binds and regulates the ileal BB Na+/H+ exchanger NHE3 Gastroenterology. 124: A471. DOI: 10.1016/S0016-5085(03)82384-3 |
0.377 |
|
| 2003 |
Li X, Cheong A, Leu S, Zhang H, Donowitz M. Carbachol-mediated inhibition of Na/H exchanger 3 (NHE3) in ileal brush border (BB) occurs through regulated trafficking and complex formation and involves multiple pools of NHE3 Gastroenterology. 124: A308-A309. DOI: 10.1016/S0016-5085(03)81554-8 |
0.402 |
|
| 2003 |
Lee-Kwon W, Kawano K, Choi JW, Kim J, Donowitz M. Lysophosphatidic acid stimulates the brush border Na/H exchanger NHE3 in Na absorptive epithelial cells by increasing exocytic trafficking by a PI 3-kinase dependent mechanism that requires E3KARP Gastroenterology. 124: A40. DOI: 10.1016/S0016-5085(03)80196-8 |
0.431 |
|
| 2002 |
Akhter S, Kovbasnjuk O, Li X, Cavet M, Noel J, Arpin M, Hubbard AL, Donowitz M. Na(+)/H(+) exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cells. American Journal of Physiology. Cell Physiology. 283: C927-40. PMID 12176749 DOI: 10.1152/Ajpcell.00613.2001 |
0.589 |
|
| 2002 |
Mahon MJ, Donowitz M, Yun CC, Segre GV. Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature. 417: 858-61. PMID 12075354 DOI: 10.1038/Nature00816 |
0.382 |
|
| 2002 |
Kim JH, Lee-Kwon W, Park JB, Ryu SH, Yun CH, Donowitz M. Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis. The Journal of Biological Chemistry. 277: 23714-24. PMID 11948184 DOI: 10.1074/Jbc.M200835200 |
0.336 |
|
| 2002 |
Brett CL, Wei Y, Donowitz M, Rao R. Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. American Journal of Physiology. Cell Physiology. 282: C1031-41. PMID 11940519 DOI: 10.1152/Ajpcell.00420.2001 |
0.757 |
|
| 2002 |
Edwards SL, Donald JA, Toop T, Donowitz M, Tse CM. Immunolocalisation of sodium/proton exchanger-like proteins in the gills of elasmobranchs. Comparative Biochemistry and Physiology. Part a, Molecular & Integrative Physiology. 131: 257-65. PMID 11818215 DOI: 10.1016/S1095-6433(01)00449-4 |
0.414 |
|
| 2001 |
Li X, Galli T, Leu S, Wade JB, Weinman EJ, Leung G, Cheong A, Louvard D, Donowitz M. Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. The Journal of Physiology. 537: 537-52. PMID 11731584 DOI: 10.1111/J.1469-7793.2001.00537.X |
0.365 |
|
| 2001 |
Cavet ME, Akhter S, Murtazina R, Sanchez de Medina F, Tse CM, Donowitz M. Half-lives of plasma membrane Na(+)/H(+) exchangers NHE1-3: plasma membrane NHE2 has a rapid rate of degradation. American Journal of Physiology. Cell Physiology. 281: C2039-48. PMID 11698263 DOI: 10.1152/Ajpcell.2001.281.6.C2039 |
0.635 |
|
| 2001 |
Lee-Kwon W, Johns DC, Cha B, Cavet M, Park J, Tsichlis P, Donowitz M. Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3. The Journal of Biological Chemistry. 276: 31296-304. PMID 11375999 DOI: 10.1074/Jbc.M103900200 |
0.36 |
|
| 2001 |
Wade JB, Welling PA, Donowitz M, Shenolikar S, Weinman EJ. Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. American Journal of Physiology. Cell Physiology. 280: C192-8. PMID 11121391 DOI: 10.1152/Ajpcell.2001.280.1.C192 |
0.409 |
|
| 2001 |
Cha B, Kim J, Hut H, Kwon WL, Nadarajah J, Tse M, Cavet M, Yun C, DeJonge H, Donowitz M. E3KARP (NHE3 kinase a anchoring protein) is necessary for cGMP regulation of NHE3: Demonstration of a plasma membrane signaling complex containing NHE3, E3KARP, and cGMP kinase II Gastroenterology. 120: A85. DOI: 10.1016/S0016-5085(08)80420-9 |
0.329 |
|
| 2000 |
Donowitz M, Janecki A, Akhter S, Cavet ME, Sanchez F, Lamprecht G, Zizak M, Kwon WL, Khurana S, Yun CH, Tse CM. Short-term regulation of NHE3 by EGF and protein kinase C but not protein kinase A involves vesicle trafficking in epithelial cells and fibroblasts. Annals of the New York Academy of Sciences. 915: 30-42. PMID 11193592 DOI: 10.1111/J.1749-6632.2000.Tb05221.X |
0.641 |
|
| 2000 |
Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. The Embo Journal. 19: 6778-91. PMID 11118213 DOI: 10.1093/Emboj/19.24.6778 |
0.35 |
|
| 2000 |
Turner JR, Black ED, Ward J, Tse CM, Uchwat FA, Alli HA, Donowitz M, Madara JL, Angle JM. Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3. American Journal of Physiology. Cell Physiology. 279: C1918-24. PMID 11078707 DOI: 10.1152/Ajpcell.2000.279.6.C1918 |
0.413 |
|
| 2000 |
Janecki AJ, Janecki M, Akhter S, Donowitz M. Quantitation of plasma membrane expression of a fusion protein of Na/H exchanger NHE3 and green fluorescence protein (GFP) in living PS120 fibroblasts. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 48: 1479-92. PMID 11036091 DOI: 10.1177/002215540004801105 |
0.586 |
|
| 2000 |
Zizak M, Cavet ME, Bayle D, Tse CM, Hallen S, Sachs G, Donowitz M. Na(+)/H(+) exchanger NHE3 has 11 membrane spanning domains and a cleaved signal peptide: topology analysis using in vitro transcription/translation. Biochemistry. 39: 8102-12. PMID 10891093 DOI: 10.1021/Bi000870T |
0.359 |
|
| 2000 |
Weinman EJ, Steplock D, Donowitz M, Shenolikar S. NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry. 39: 6123-9. PMID 10821685 DOI: 10.1021/Bi000064M |
0.462 |
|
| 2000 |
Janecki AJ, Janecki M, Akhter S, Donowitz M. Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 275: 8133-42. PMID 10713136 DOI: 10.1074/Jbc.275.11.8133 |
0.601 |
|
| 2000 |
Akhter S, Cavet ME, Tse CM, Donowitz M. C-terminal domains of Na(+)/H(+) exchanger isoform 3 are involved in the basal and serum-stimulated membrane trafficking of the exchanger. Biochemistry. 39: 1990-2000. PMID 10684649 DOI: 10.1021/Bi991739S |
0.606 |
|
| 2000 |
Donowitz M, Tse M. Chapter 12 Molecular physiology of mammalian epithelial Na+/H+ exchangers NHE2 and NHE3 Current Topics in Membranes. 50: 437-451,IN2,452-498. DOI: 10.1016/S1063-5823(00)50014-3 |
0.434 |
|
| 2000 |
Hogan D, Repishti M, Pratha V, Donowitz M, Tse M, Isenberg J. Human duodenal bicarbonate absorption involves both brush border NA+/H+ exchangers NHE2 and NHE3 Gastroenterology. 118: A606. DOI: 10.1016/S0016-5085(00)84562-X |
0.394 |
|
| 2000 |
Li X, Galli T, Louvard D, Donowitz M. NA+/H+-exchanger 3 (NHE3) is present in lipid rafts in the ileal absorptive cell brush border: A role for rafts and the actin cytoskeleton in endocytosis of NHE3 Gastroenterology. 118: A599. DOI: 10.1016/S0016-5085(00)84536-9 |
0.385 |
|
| 2000 |
Cavet ME, Akhter S, Tse C, Donowitz M. Differences in plasma membrane half-life and membrane trafficking of the epithelial Na+/H+exchangers NHE2 and NHE3: Insights into functions of these proteins Gastroenterology. 118: A597. DOI: 10.1016/S0016-5085(00)84527-8 |
0.594 |
|
| 2000 |
Akhter S, Kovbasnjuk O, Hubbard A, Donowitz M. Separate functions for brush border membrane and endosomal NHE3 in a polarized epithelial cell line Gastroenterology. 118: A596. DOI: 10.1016/S0016-5085(00)84523-0 |
0.524 |
|
| 2000 |
Janecki AJ, Donowitz M, Janecki M. Expression and regulation of a fusion protein of naih exchanger NHE3 and green fluorescent protein in epithelial Caco-2 cells Gastroenterology. 118: A84. DOI: 10.1016/S0016-5085(00)82413-0 |
0.322 |
|
| 1999 |
Janecki AJ, Montrose MH, Tse CM, de Medina FS, Zweibaum A, Donowitz M. Development of an endogenous epithelial Na/Hexchanger (NHE3) in three clones of Caco-2 cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 277: G292-G305. PMID 29591707 DOI: 10.1152/ajpgi.1999.277.2.G292 |
0.347 |
|
| 1999 |
Cavet ME, Akhter S, de Medina FS, Donowitz M, Tse CM. Na/Hexchangers (NHE1-3) have similar turnover numbers but different percentages on the cell surface. American Journal of Physiology. Cell Physiology. 277: C1111-C1121. PMID 29591090 DOI: 10.1152/ajpcell.1999.277.6.C1111 |
0.483 |
|
| 1999 |
Akhter S, Nath SK, Tse CM, Williams J, Zasloff M, Donowitz M. Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na/Hexchanger isoform NHE3. American Journal of Physiology. Cell Physiology. 276: C136-C144. PMID 29590794 DOI: 10.1152/ajpcell.1999.276.1.C136 |
0.598 |
|
| 1999 |
Cavet ME, Akhter S, de Medina FS, Donowitz M, Tse CM. Na(+)/H(+) exchangers (NHE1-3) have similar turnover numbers but different percentages on the cell surface. The American Journal of Physiology. 277: C1111-21. PMID 10600762 DOI: 10.1152/Ajpcell.1999.277.6.C1111 |
0.613 |
|
| 1999 |
Zizak M, Lamprecht G, Steplock D, Tariq N, Shenolikar S, Donowitz M, Yun CH, Weinman EJ. cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. The Journal of Biological Chemistry. 274: 24753-8. PMID 10455146 DOI: 10.1074/Jbc.274.35.24753 |
0.398 |
|
| 1999 |
Janecki AJ, Montrose MH, Tse CM, de Medina FS, Zweibaum A, Donowitz M. Development of an endogenous epithelial Na(+)/H(+) exchanger (NHE3) in three clones of caco-2 cells. The American Journal of Physiology. 277: G292-305. PMID 10444443 DOI: 10.1152/Ajpgi.1999.277.2.G292 |
0.464 |
|
| 1999 |
Nath SK, Kambadur R, Yun CH, Donowitz M, Tse CM. NHE2 contains subdomains in the COOH terminus for growth factor and protein kinase regulation. The American Journal of Physiology. 276: C873-82. PMID 10199818 DOI: 10.1152/Ajpcell.1999.276.4.C873 |
0.362 |
|
| 1999 |
Akhter S, Nath SK, Tse CM, Williams J, Zasloff M, Donowitz M. Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na+/H+ exchanger isoform NHE3. The American Journal of Physiology. 276: C136-44. PMID 9886929 DOI: 10.1152/Ajpcell.1999.276.1.C136 |
0.636 |
|
| 1998 |
Wormmeester L, De Medina FS, Kokke F, Tse CM, Khurana S, Bowser J, Cohen ME, Donowitz M. Quantitative contribution of NHE2 and NHE3 to rabbit ileal brush-border Na/Hexchange. American Journal of Physiology. Cell Physiology. 274: C1261-C1272. PMID 29591067 DOI: 10.1152/ajpcell.1998.274.5.C1261 |
0.306 |
|
| 1998 |
Lee MG, Schultheis PJ, Yan M, Shull GE, Bookstein C, Chang E, Tse M, Donowitz M, Park K, Muallem S. Membrane-limited expression and regulation of Na+-H+ exchanger isoforms by P2 receptors in the rat submandibular gland duct. The Journal of Physiology. 513: 341-57. PMID 9806987 DOI: 10.1111/J.1469-7793.1998.341Bb.X |
0.405 |
|
| 1998 |
Donowitz M, Khurana S, Tse CM, Yun CH. G protein-coupled receptors in gastrointestinal physiology. III. Asymmetry in plasma membrane signal transduction: lessons from brush-border Na+/H+ exchangers. The American Journal of Physiology. 274: G971-7. PMID 9696719 DOI: 10.1152/Ajpgi.1998.274.6.G971 |
0.379 |
|
| 1998 |
Wormmeester L, Sanchez de Medina F, Kokke F, Tse CM, Khurana S, Bowser J, Cohen ME, Donowitz M. Quantitative contribution of NHE2 and NHE3 to rabbit ileal brush-border Na+/H+ exchange. The American Journal of Physiology. 274: C1261-72. PMID 9612213 DOI: 10.1152/Ajpcell.1998.274.5.C1261 |
0.431 |
|
| 1998 |
Donowitz M, De La Horra C, Calonge ML, Wood IS, Dyer J, Gribble SM, De Medina FS, Tse CM, Shirazi-Beechey SP, Ilundain AA. In birds, NHE2 is major brush-border Na+/H+ exchanger in colon and is increased by a low-NaCl diet. The American Journal of Physiology. 274: R1659-69. PMID 9608021 DOI: 10.1152/Ajpregu.1998.274.6.R1659 |
0.411 |
|
| 1998 |
Janecki AJ, Montrose MH, Zimniak P, Zweibaum A, Tse CM, Khurana S, Donowitz M. Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger. The Journal of Biological Chemistry. 273: 8790-8. PMID 9535857 DOI: 10.1074/Jbc.273.15.8790 |
0.469 |
|
| 1998 |
He X, Kuijpers GA, Goping G, Kulakusky JA, Zheng C, Delporte C, Tse CM, Redman RS, Donowitz M, Pollard HB, Baum BJ. A polarized salivary cell monolayer useful for studying transepithelial fluid movement in vitro. Pflã¼Gers Archiv : European Journal of Physiology. 435: 375-81. PMID 9426293 DOI: 10.1007/S004240050526 |
0.374 |
|
| 1998 |
Yun C, Lamprecht G, Weinman E, Donowitz M. Na+/H+ exchanger NHE3 interacts with PDZ domains of the regulatory proteins, E3KARP and NHERF Gastroenterology. 114: A436. DOI: 10.1016/S0016-5085(98)81764-2 |
0.371 |
|
| 1998 |
Cavet M, Tse C, Akhter S, Yun C, Donowitz M. Structure-function studies of membrane domain-cytoplasmic domain and membrane domain-membrane doman chimeras of Na+/H+ exchanger isoforms NHE1 and NHE3 Gastroenterology. 114: A357. DOI: 10.1016/S0016-5085(98)81447-9 |
0.57 |
|
| 1998 |
Akhter S, Cavet M, Tse C, Donowitz M. Regulatory mechanisms of cloned Na+/H+ exchangers involve change in the amount of plasma membrane exchanger: Use of cell surface biotinylation Gastroenterology. 114: A347. DOI: 10.1016/S0016-5085(98)81405-4 |
0.602 |
|
| 1997 |
Khurana S, Arpin M, Patterson R, Donowitz M. Ileal microvillar protein villin is tyrosine-phosphorylated and associates with PLC-gamma1. Role of cytoskeletal rearrangement in the carbachol-induced inhibition of ileal NaCl absorption. The Journal of Biological Chemistry. 272: 30115-21. PMID 9374490 DOI: 10.1074/Jbc.272.48.30115 |
0.395 |
|
| 1997 |
Sun AM, Liu Y, Dworkin LD, Tse CM, Donowitz M, Yip KP. Na+/H+ exchanger isoform 2 (NHE2) is expressed in the apical membrane of the medullary thick ascending limb. The Journal of Membrane Biology. 160: 85-90. PMID 9351894 DOI: 10.1007/S002329900297 |
0.354 |
|
| 1997 |
Yip JW, Ko WH, Viberti G, Huganir RL, Donowitz M, Tse CM. Regulation of the epithelial brush border Na+/H+ exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger. The Journal of Biological Chemistry. 272: 18473-80. PMID 9218492 DOI: 10.1074/Jbc.272.29.18473 |
0.378 |
|
| 1997 |
Yun CH, Oh S, Zizak M, Steplock D, Tsao S, Tse CM, Weinman EJ, Donowitz M. cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 3010-5. PMID 9096337 DOI: 10.1073/Pnas.94.7.3010 |
0.463 |
|
| 1997 |
Helmle-Kolb C, Di Sole F, Forgo J, Hilfiker H, Tse CM, Casavola V, Donowitz M, Murer H. Regulation of the transfected Na+/H+-exchanger NHE3 in MDCK cells by vasotocin. Pflã¼Gers Archiv : European Journal of Physiology. 434: 123-31. PMID 9094265 DOI: 10.1007/S004240050372 |
0.465 |
|
| 1997 |
He X, Tse CM, Donowitz M, Alper SL, Gabriel SE, Baum BJ. Polarized distribution of key membrane transport proteins in the rat submandibular gland. Pflã¼Gers Archiv : European Journal of Physiology. 433: 260-8. PMID 9064641 DOI: 10.1007/S004240050276 |
0.41 |
|
| 1997 |
Maher MM, Gontarek JD, Bess RS, Donowitz M, Yeo CJ. The Na+/H+ exchange isoform NHE3 regulates basal canine ileal Na+ absorption in vivo. Gastroenterology. 112: 174-83. PMID 8978356 DOI: 10.1016/S0016-5085(97)70232-4 |
0.349 |
|
| 1997 |
Janecki A, Khurana S, Montrose M, Zimniak P, Donowitz M. Protein kinase C (PKC) is involved in translocation of endogenous apical NA/H exchanger (NHE3) in human colonic adenocarcinoma cells CACO-2 Faseb Journal. 11: A513. |
0.321 |
|
| 1996 |
Burnett AL, Donowitz M, Marshall FF. Inhibition of transport processes of intestinal segments following augmentation enterocystoplasty in rats. The Journal of Urology. 156: 1872-5. PMID 8863635 DOI: 10.1016/S0022-5347(01)65556-3 |
0.321 |
|
| 1996 |
Hoogerwerf WA, Tsao SC, Devuyst O, Levine SA, Yun CH, Yip JW, Cohen ME, Wilson PD, Lazenby AJ, Tse CM, Donowitz M. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. The American Journal of Physiology. 270: G29-41. PMID 8772498 DOI: 10.1152/Ajpgi.1996.270.1.G29 |
0.423 |
|
| 1996 |
Maher MM, Gontarek JD, Jimenez RE, Donowitz M, Yeo CJ. Role of brush border Na+/H+ exchange in canine ileal absorption. Digestive Diseases and Sciences. 41: 651-9. PMID 8674384 DOI: 10.1007/Bf02213119 |
0.389 |
|
| 1996 |
Nath SK, Hang CY, Levine SA, Yun CH, Montrose MH, Donowitz M, Tse CM. Hyperosmolarity inhibits the Na+/H+ exchanger isoforms NHE2 and NHE3: an effect opposite to that on NHE1. The American Journal of Physiology. 270: G431-41. PMID 8638709 DOI: 10.1152/Ajpgi.1996.270.3.G431 |
0.422 |
|
| 1996 |
Khurana S, Nath SK, Levine SA, Bowser JM, Tse CM, Cohen ME, Donowitz M. Brush border phosphatidylinositol 3-kinase mediates epidermal growth factor stimulation of intestinal NaCl absorption and Na+/H+ exchange. The Journal of Biological Chemistry. 271: 9919-27. PMID 8626628 DOI: 10.1074/Jbc.271.17.9919 |
0.436 |
|
| 1996 |
Khurana S, Kreydiyyeh S, Aronzon A, Hoogerwerf WA, Rhee SG, Donowitz M, Cohen ME. Asymmetric signal transduction in polarized ileal Na(+)-absorbing cells: carbachol activates brush-border but not basolateral-membrane PIP2-PLC and translocates PLC-gamma 1 only to the brush border. The Biochemical Journal. 313: 509-18. PMID 8573085 DOI: 10.1042/Bj3130509 |
0.42 |
|
| 1995 |
Sears CL, Firoozmand F, Mellander A, Chambers FG, Eromar IG, Bot AG, Scholte B, De Jonge HR, Donowitz M. Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers. The American Journal of Physiology. 269: G874-82. PMID 8572219 DOI: 10.1152/Ajpgi.1995.269.6.G874 |
0.393 |
|
| 1995 |
Levine SA, Nath SK, Yun CH, Yip JW, Montrose M, Donowitz M, Tse CM. Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors. The Journal of Biological Chemistry. 270: 13716-25. PMID 7775426 DOI: 10.1074/Jbc.270.23.13716 |
0.41 |
|
| 1995 |
Yun CH, Tse CM, Nath S, Levine SL, Donowitz M. Structure/function studies of mammalian Na-H exchangers--an update. The Journal of Physiology. 482: 1S-6S. PMID 7730970 DOI: 10.1113/Jphysiol.1995.Sp020558 |
0.376 |
|
| 1995 |
Yun CH, Tse CM, Nath SK, Levine SA, Brant SR, Donowitz M. Mammalian Na+/H+ exchanger gene family: structure and function studies. The American Journal of Physiology. 269: G1-11. PMID 7631785 DOI: 10.1152/Ajpgi.1995.269.1.G1 |
0.428 |
|
| 1995 |
Brant SR, Yun CH, Donowitz M, Tse CM. Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3. The American Journal of Physiology. 269: C198-206. PMID 7631746 DOI: 10.1152/Ajpcell.1995.269.1.C198 |
0.358 |
|
| 1995 |
Yun CH, Tse CM, Donowitz M. Chimeric Na+/H+ exchangers: an epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 92: 10723-7. PMID 7479872 DOI: 10.1073/Pnas.92.23.10723 |
0.434 |
|
| 1994 |
Donowitz M, Montgomery JL, Walker MS, Cohen ME. Brush-border tyrosine phosphorylation stimulates ileal neutral NaCl absorption and brush-border Na(+)-H+ exchange. The American Journal of Physiology. 266: G647-56. PMID 8179002 DOI: 10.1152/Ajpgi.1994.266.4.G647 |
0.423 |
|
| 1994 |
Homaidan FR, Tang SH, Donowitz M, Sharp GW. Effects of galanin on short circuit current and electrolyte transport in rabbit ileum. Peptides. 15: 1431-6. PMID 7535426 DOI: 10.1016/0196-9781(94)90120-1 |
0.404 |
|
| 1994 |
Tse CM, Levine SA, Yun CH, Khurana S, Donowitz M. Na+/H+ exchanger-2 is an O-linked but not an N-linked sialoglycoprotein. Biochemistry. 33: 12954-61. PMID 7524659 DOI: 10.1021/Bi00248A003 |
0.372 |
|
| 1994 |
Tse CM, Levine SA, Yun CHC, Brant SR, Natha S, Pouysségur J, Donowitz M. Molecular properties, kinetics and regulation of mammalian Na+/H+ exchangers Cellular Physiology and Biochemistry. 4: 282-300. DOI: 10.1159/000154731 |
0.439 |
|
| 1993 |
Yun CH, Little PJ, Nath SK, Levine SA, Pouyssegur J, Tse CM, Donowitz M. Leu143 in the putative fourth membrane spanning domain is critical for amiloride inhibition of an epithelial Na+/H+ exchanger isoform (NHE-2). Biochemical and Biophysical Research Communications. 193: 532-9. PMID 8512555 DOI: 10.1006/Bbrc.1993.1656 |
0.412 |
|
| 1993 |
Tse CM, Levine SA, Yun CH, Brant SR, Pouyssegur J, Montrose MH, Donowitz M. Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 90: 9110-4. PMID 8415663 DOI: 10.1073/Pnas.90.19.9110 |
0.449 |
|
| 1993 |
Tse M, Levine S, Yun C, Brant S, Counillon LT, Pouyssegur J, Donowitz M. Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family. The Journal of Membrane Biology. 135: 93-108. PMID 8411138 DOI: 10.1007/Bf00231435 |
0.348 |
|
| 1993 |
Yun CH, Gurubhagavatula S, Levine SA, Montgomery JL, Brant SR, Cohen ME, Cragoe EJ, Pouyssegur J, Tse CM, Donowitz M. Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform. The Journal of Biological Chemistry. 268: 206-11. PMID 8380155 |
0.306 |
|
| 1993 |
Mrkic B, Tse CM, Forgo J, Helmle-Kolb C, Donowitz M, Murer H. Identification of PTH-responsive Na/H-exchanger isoforms in a rabbit proximal tubule cell line (RKPC-2). Pflã¼Gers Archiv : European Journal of Physiology. 424: 377-84. PMID 8255719 DOI: 10.1007/Bf00374897 |
0.466 |
|
| 1993 |
Levine SA, Montrose MH, Tse CM, Donowitz M. Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line. The Journal of Biological Chemistry. 268: 25527-35. PMID 8244988 |
0.337 |
|
| 1993 |
Brant SR, Bernstein M, Wasmuth JJ, Taylor EW, McPherson JD, Li X, Walker S, Pouyssegur J, Donowitz M, Tse CM. Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3. Genomics. 15: 668-72. PMID 8096830 DOI: 10.1006/Geno.1993.1122 |
0.329 |
|
| 1993 |
Tse CM, Levine SA, Yun CH, Montrose MH, Little PJ, Pouyssegur J, Donowitz M. Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). The Journal of Biological Chemistry. 268: 11917-24. PMID 7685025 |
0.326 |
|
| 1992 |
Zeitlin PL, Crawford I, Lu L, Woel S, Cohen ME, Donowitz M, Montrose MH, Hamosh A, Cutting GR, Gruenert D. CFTR protein expression in primary and cultured epithelia. Proceedings of the National Academy of Sciences of the United States of America. 89: 344-7. PMID 1370353 DOI: 10.1073/Pnas.89.1.344 |
0.336 |
|
| 1991 |
Cohen ME, Wesolek J, McCullen J, Rys-Sikora K, Pandol S, Rood RP, Sharp GW, Donowitz M. Carbachol- and elevated Ca(2+)-induced translocation of functionally active protein kinase C to the brush border of rabbit ileal Na+ absorbing cells. The Journal of Clinical Investigation. 88: 855-63. PMID 1885773 DOI: 10.1172/Jci115387 |
0.406 |
|
| 1991 |
Tse CM, Ma AI, Yang VW, Watson AJ, Levine S, Montrose MH, Potter J, Sardet C, Pouyssegur J, Donowitz M. Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger. The Embo Journal. 10: 1957-67. PMID 1712287 DOI: 10.1002/J.1460-2075.1991.Tb07725.X |
0.427 |
|
| 1991 |
Levine SA, Donowitz M, Watson AJ, Sharp GW, Crane JK, Weikel CS. Characterization of the synergistic interaction of Escherichia coli heat-stable toxin and carbachol. The American Journal of Physiology. 261: G592-601. PMID 1656772 DOI: 10.1152/Ajpgi.1991.261.4.G592 |
0.314 |
|
| 1991 |
Watson AJ, Levine S, Donowitz M, Montrose MH. Kinetics and regulation of a polarized Na(+)-H+ exchanger from Caco-2 cells, a human intestinal cell line. The American Journal of Physiology. 261: G229-38. PMID 1651659 DOI: 10.1152/Ajpgi.1991.261.2.G229 |
0.448 |
|
| 1990 |
Cohen ME, Reinlib L, Watson AJ, Gorelick F, Rys-Sikora K, Tse M, Rood RP, Czernik AJ, Sharp GW, Donowitz M. Rabbit ileal villus cell brush border Na+/H+ exchange is regulated by Ca2+/calmodulin-dependent protein kinase II, a brush border membrane protein. Proceedings of the National Academy of Sciences of the United States of America. 87: 8990-4. PMID 2174171 DOI: 10.1073/Pnas.87.22.8990 |
0.386 |
|
| 1990 |
McGowan K, Piver G, Stoff JS, Donowitz M. Role of prostaglandins and calcium in the effects of Entamoeba histolytica on colonic electrolyte transport. Gastroenterology. 98: 873-80. PMID 2155844 DOI: 10.1016/0016-5085(90)90010-X |
0.351 |
|
| 1986 |
Donowitz M, Welsh MJ. Ca2+ and cyclic AMP in regulation of intestinal Na, K, and Cl transport. Annual Review of Physiology. 48: 135-50. PMID 3010813 DOI: 10.1146/Annurev.Ph.48.030186.001031 |
0.395 |
|
| 1982 |
Charney AN, Wallach JD, Donowitz M, Johnstone N. Effect of cycloheximide on corticosteroid-induced changes in colonic function. The American Journal of Physiology. 243: G112-6. PMID 6287851 DOI: 10.1152/Ajpgi.1982.243.2.G112 |
0.352 |
|
| 1978 |
Charney AN, Donowitz M, Costenbader CL. Effect of spironolactone on mineralo and glucocorticoid — induced increases in colonic NA and water absorption and Na-K-ATPase activity Gastroenterology. 74: 1018. DOI: 10.1016/0016-5085(78)93063-9 |
0.344 |
|
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