Luciano Rossetti - Publications

Affiliations: 
Yeshiva University, New York, NY, United States 
Area:
Animal Physiology Biology, Neuroscience Biology, Pharmacology, Pathology

145 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Knight CM, Gutierrez-Juarez R, Lam TKT, Arrieta-Cruz I, Huang L, Schwartz G, Barzilai N, Rossetti L. Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol's Effects on Insulin Action in Rats. Diabetes 2011;60:2691-2700. Diabetes. 66: 3143-3144. PMID 29162736 DOI: 10.2337/Db17-Er12C  0.57
2017 Knight CM, Gutierrez-Juarez R, Lam TKT, Arrieta-Cruz I, Huang L, Schwartz G, Barzilai N, Rossetti L. Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol's Effects on Insulin Action in Rats. Diabetes 2011;60:2691-2700. Diabetes. PMID 28982655 DOI: 10.2337/db17-er12C  0.371
2011 Knight CM, Gutierrez-Juarez R, Lam TK, Arrieta-Cruz I, Huang L, Schwartz G, Barzilai N, Rossetti L. Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes. 60: 2691-700. PMID 21896928 DOI: 10.2337/Db10-0987  0.619
2011 Hawkins M, Rossetti L. Insulin resistance and its role in the pathogenesis of type 2 diabetes Joslin's Diabetes Mellitus: Fourteenth Edition. 425-448.  0.323
2010 Ross RA, Rossetti L, Lam TK, Schwartz GJ. Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production. American Journal of Physiology. Endocrinology and Metabolism. 299: E633-9. PMID 20647558 DOI: 10.1152/Ajpendo.00190.2010  0.701
2010 Lin HV, Plum L, Ono H, Gutiérrez-Juárez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes. 59: 337-46. PMID 19933998 DOI: 10.2337/Db09-1303  0.534
2009 Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Molecular and Cellular Biology. 29: 5070-83. PMID 19596788 DOI: 10.1128/Mcb.00138-09  0.469
2009 Kokorovic A, Cheung GW, Rossetti L, Lam TK. Hypothalamic sensing of circulating lactate regulates glucose production. Journal of Cellular and Molecular Medicine. 13: 4403-8. PMID 19040414 DOI: 10.1111/J.1582-4934.2008.00596.X  0.494
2008 Banks AS, Kon N, Knight C, Matsumoto M, Gutiérrez-Juárez R, Rossetti L, Gu W, Accili D. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metabolism. 8: 333-41. PMID 18840364 DOI: 10.1016/J.Cmet.2008.08.014  0.549
2008 Ono H, Pocai A, Wang Y, Sakoda H, Asano T, Backer JM, Schwartz GJ, Rossetti L. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. The Journal of Clinical Investigation. 118: 2959-68. PMID 18618016 DOI: 10.1172/Jci34277  0.679
2008 Buettner C, Muse ED, Cheng A, Chen L, Scherer T, Pocai A, Su K, Cheng B, Li X, Harvey-White J, Schwartz GJ, Kunos G, Rossetti L, Buettner C. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nature Medicine. 14: 667-75. PMID 18516053 DOI: 10.1038/Nm1775  0.526
2008 Ross R, Wang PY, Chari M, Lam CK, Caspi L, Ono H, Muse ED, Li X, Gutierrez-Juarez R, Light PE, Schwartz GJ, Rossetti L, Lam TK. Hypothalamic protein kinase C regulates glucose production. Diabetes. 57: 2061-5. PMID 18511848 DOI: 10.2337/Db08-0206  0.704
2008 Scapa EF, Pocai A, Wu MK, Gutierrez-Juarez R, Glenz L, Kanno K, Li H, Biddinger S, Jelicks LA, Rossetti L, Cohen DE. Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2579-90. PMID 18347010 DOI: 10.1096/Fj.07-105395  0.512
2007 Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metabolism. 6: 208-16. PMID 17767907 DOI: 10.1016/J.Cmet.2007.08.006  0.56
2007 Muse ED, Lam TK, Scherer PE, Rossetti L. Hypothalamic resistin induces hepatic insulin resistance. The Journal of Clinical Investigation. 117: 1670-8. PMID 17525801 DOI: 10.1172/Jci30440  0.445
2007 Lin HV, Kim JY, Pocai A, Rossetti L, Shapiro L, Scherer PE, Accili D. Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes. 56: 1969-76. PMID 17475934 DOI: 10.2337/Db07-0127  0.56
2007 Lam TK, Gutierrez-Juarez R, Pocai A, Bhanot S, Tso P, Schwartz GJ, Rossetti L. Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nature Medicine. 13: 171-80. PMID 17273170 DOI: 10.1038/Nm1540  0.665
2006 Yang TT, Suk HY, Yang X, Olabisi O, Yu RY, Durand J, Jelicks LA, Kim JY, Scherer PE, Wang Y, Feng Y, Rossetti L, Graef IA, Crabtree GR, Chow CW. Role of transcription factor NFAT in glucose and insulin homeostasis. Molecular and Cellular Biology. 26: 7372-87. PMID 16908540 DOI: 10.1128/Mcb.00580-06  0.548
2006 Buettner C, Pocai A, Muse ED, Etgen AM, Myers MG, Rossetti L. Critical role of STAT3 in leptin's metabolic actions. Cell Metabolism. 4: 49-60. PMID 16814732 DOI: 10.1016/J.Cmet.2006.04.014  0.501
2006 Gutiérrez-Juárez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia BP, Rossetti L. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. The Journal of Clinical Investigation. 116: 1686-95. PMID 16741579 DOI: 10.1172/Jci26991  0.574
2006 Kitamura T, Feng Y, Kitamura YI, Chua SC, Xu AW, Barsh GS, Rossetti L, Accili D. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nature Medicine. 12: 534-40. PMID 16604086 DOI: 10.1038/Nm1392  0.321
2006 Pocai A, Lam TK, Obici S, Gutierrez-Juarez R, Muse ED, Arduini A, Rossetti L. Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. The Journal of Clinical Investigation. 116: 1081-91. PMID 16528412 DOI: 10.1172/Jci26640  0.47
2006 He W, Lam TK, Obici S, Rossetti L. Molecular disruption of hypothalamic nutrient sensing induces obesity. Nature Neuroscience. 9: 227-33. PMID 16415870 DOI: 10.1038/Nn1626  0.398
2006 Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. The Journal of Biological Chemistry. 281: 2654-60. PMID 16326714 DOI: 10.1074/Jbc.M505311200  0.585
2005 Pocai A, Morgan K, Buettner C, Gutierrez-Juarez R, Obici S, Rossetti L. Central leptin acutely reverses diet-induced hepatic insulin resistance. Diabetes. 54: 3182-9. PMID 16249443 DOI: 10.2337/Diabetes.54.11.3182  0.776
2005 Lam TK, Gutierrez-Juarez R, Pocai A, Rossetti L. Regulation of blood glucose by hypothalamic pyruvate metabolism. Science (New York, N.Y.). 309: 943-7. PMID 16081739 DOI: 10.1126/Science.1112085  0.553
2005 Pocai A, Obici S, Schwartz GJ, Rossetti L. A brain-liver circuit regulates glucose homeostasis. Cell Metabolism. 1: 53-61. PMID 16054044 DOI: 10.1016/J.Cmet.2004.11.001  0.59
2005 Okamoto H, Obici S, Accili D, Rossetti L. Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. The Journal of Clinical Investigation. 115: 1314-22. PMID 15864351 DOI: 10.1172/Jci23096  0.532
2005 Buettner C, Patel R, Muse ED, Bhanot S, Monia BP, McKay R, Obici S, Rossetti L. Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice. The Journal of Clinical Investigation. 115: 1306-13. PMID 15864350 DOI: 10.1172/Jci23109  0.579
2005 Lam TK, Schwartz GJ, Rossetti L. Hypothalamic sensing of fatty acids. Nature Neuroscience. 8: 579-84. PMID 15856066 DOI: 10.1038/Nn1456  0.491
2005 Pocai A, Lam TK, Gutierrez-Juarez R, Obici S, Schwartz GJ, Bryan J, Aguilar-Bryan L, Rossetti L. Hypothalamic K(ATP) channels control hepatic glucose production. Nature. 434: 1026-31. PMID 15846348 DOI: 10.1038/Nature03439  0.664
2005 Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz GJ, Rossetti L. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nature Medicine. 11: 320-7. PMID 15735652 DOI: 10.1038/Nm1201  0.634
2004 Gutiérrez-Juárez R, Obici S, Rossetti L. Melanocortin-independent effects of leptin on hepatic glucose fluxes. The Journal of Biological Chemistry. 279: 49704-15. PMID 15364916 DOI: 10.1074/Jbc.M408665200  0.561
2004 Muse ED, Obici S, Bhanot S, Monia BP, McKay RA, Rajala MW, Scherer PE, Rossetti L. Role of resistin in diet-induced hepatic insulin resistance. The Journal of Clinical Investigation. 114: 232-9. PMID 15254590 DOI: 10.1172/Jci21270  0.542
2004 Rangwala SM, Rich AS, Rhoades B, Shapiro JS, Obici S, Rossetti L, Lazar MA. Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes. 53: 1937-41. PMID 15189975 DOI: 10.2337/Diabetes.53.8.1937  0.513
2004 Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L. Disulfide-dependent multimeric assembly of resistin family hormones. Science (New York, N.Y.). 304: 1154-8. PMID 15155948 DOI: 10.1126/Science.1093466  0.323
2004 Morgan K, Obici S, Rossetti L. Hypothalamic responses to long-chain fatty acids are nutritionally regulated. The Journal of Biological Chemistry. 279: 31139-48. PMID 15155754 DOI: 10.1074/Jbc.M400458200  0.693
2004 Vanpatten S, Karkanias GB, Rossetti L, Cohen DE. Intracerebroventricular leptin regulates hepatic cholesterol metabolism. The Biochemical Journal. 379: 229-33. PMID 14984364 DOI: 10.1042/Bj20040134  0.388
2004 Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA. Regulation of fasted blood glucose by resistin. Science (New York, N.Y.). 303: 1195-8. PMID 14976316 DOI: 10.1126/Science.1092341  0.542
2004 Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, Nawrocki AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell RG, Lindemann D, Hartley A, Baker GR, ... ... Rossetti L, et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology. 145: 367-83. PMID 14576179 DOI: 10.1210/En.2003-1068  0.535
2003 Du X, Matsumura T, Edelstein D, Rossetti L, Zsengellér Z, Szabó C, Brownlee M. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. The Journal of Clinical Investigation. 112: 1049-57. PMID 14523042 DOI: 10.1172/Jci18127  0.343
2003 Obici S, Rossetti L. Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology. 144: 5172-8. PMID 12970158 DOI: 10.1210/En.2003-0999  0.385
2003 Obici S, Feng Z, Arduini A, Conti R, Rossetti L. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nature Medicine. 9: 756-61. PMID 12754501 DOI: 10.1038/Nm873  0.422
2003 Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, et al. Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 1438-43. PMID 12552113 DOI: 10.1073/Pnas.0237106100  0.494
2003 Rajala MW, Obici S, Scherer PE, Rossetti L. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. The Journal of Clinical Investigation. 111: 225-30. PMID 12531878 DOI: 10.1172/Jci16521  0.615
2002 Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nature Medicine. 8: 1376-82. PMID 12426561 DOI: 10.1038/Nm1202-798  0.598
2002 Goldstein RE, Rossetti L, Palmer BAJ, Liu R, Massillon D, Scott M, Neal D, Williams P, Peeler B, Cherrington AD. Effects of fasting and glucocorticoids on hepatic gluconeogenesis assessed using two independent methods in vivo American Journal of Physiology - Endocrinology and Metabolism. 283: E946-E957. PMID 12376321 DOI: 10.1152/Ajpendo.00320.2002  0.34
2002 Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes. 51: 2951-8. PMID 12351432 DOI: 10.2337/Diabetes.51.10.2951  0.566
2002 Hawkins M, Gabriely I, Wozniak R, Reddy K, Rossetti L, Shamoon H. Glycemic control determines hepatic and peripheral glucose effectiveness in type 2 diabetic subjects. Diabetes. 51: 2179-89. PMID 12086948 DOI: 10.2337/Diabetes.51.7.2179  0.541
2002 Obici S, Wang J, Chowdury R, Feng Z, Siddhanta U, Morgan K, Rossetti L. Identification of a biochemical link between energy intake and energy expenditure. The Journal of Clinical Investigation. 109: 1599-605. PMID 12070307 DOI: 10.1172/Jci15258  0.605
2002 Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nature Neuroscience. 5: 566-72. PMID 12021765 DOI: 10.1038/Nn0602-861  0.553
2002 Gabriely I, Ma XH, Yang XM, Rossetti L, Barzilai N. Leptin resistance during aging is independent of fat mass. Diabetes. 51: 1016-21. PMID 11916920 DOI: 10.2337/Diabetes.51.4.1016  0.416
2002 Gabriely I, Hawkins M, Vilcu C, Rossetti L, Shamoon H. Fructose amplifies counterregulatory responses to hypoglycemia in humans. Diabetes. 51: 893-900. PMID 11916904 DOI: 10.2337/Diabetes.51.4.893  0.512
2002 Hawkins M, Gabriely I, Wozniak R, Vilcu C, Shamoon H, Rossetti L. Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes. Diabetes. 51: 606-14. PMID 11872657 DOI: 10.2337/Diabetes.51.3.606  0.447
2002 Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes. 51: 271-5. PMID 11812732 DOI: 10.2337/Diabetes.51.2.271  0.671
2002 Gabriely I, Yang XM, Cases JA, Ma XH, Rossetti L, Barzilai N. Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway. Atherosclerosis. 160: 115-22. PMID 11755928 DOI: 10.1016/S0021-9150(01)00574-3  0.471
2001 Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. The Journal of Clinical Investigation. 108: 1875-81. PMID 11748271 DOI: 10.1172/Jci14120  0.573
2001 Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes. 50: 2786-91. PMID 11723062 DOI: 10.2337/Diabetes.50.12.2786  0.755
2001 Obici S, Feng Z, Tan J, Liu L, Karkanias G, Rossetti L. Central melanocortin receptors regulate insulin action. The Journal of Clinical Investigation. 108: 1079-85. PMID 11581309 DOI: 10.1172/Jci12954  0.529
2001 Gabriely I, Yang XM, Cases JA, Ma XH, Rossetti L, Barzilai N. Hyperglycemia modulates angiotensinogen gene expression. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 281: R795-802. PMID 11506994 DOI: 10.1152/Ajpregu.2001.281.3.R795  0.51
2001 Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, Cherrington AD. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes. 50: 1872-82. PMID 11473051 DOI: 10.2337/Diabetes.50.8.1872  0.585
2001 VanPatten S, Ranginani N, Shefer S, Nguyen LB, Rossetti L, Cohen DE. Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance. American Journal of Physiology. Gastrointestinal and Liver Physiology. 281: G393-404. PMID 11447020 DOI: 10.1152/Ajpgi.2001.281.2.G393  0.342
2001 Cases JA, Gabriely I, Ma XH, Yang XM, Michaeli T, Fleischer N, Rossetti L, Barzilai N. Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes. 50: 348-52. PMID 11272146 DOI: 10.2337/Diabetes.50.2.348  0.579
2000 Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, Wu J, Brownlee M. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proceedings of the National Academy of Sciences of the United States of America. 97: 12222-6. PMID 11050244 DOI: 10.1073/Pnas.97.22.12222  0.311
2000 Gupta G, Cases JA, She L, Ma XH, Yang XM, Hu M, Wu J, Rossetti L, Barzilai N. Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation. American Journal of Physiology. Endocrinology and Metabolism. 278: E985-91. PMID 10826999 DOI: 10.1152/Ajpendo.2000.278.6.E985  0.521
2000 Mevorach M, Kaplan J, Chang CJ, Rossetti L, Shamoon H. Hormone-independent activation of EGP during hypoglycemia is absent in type 1 diabetes mellitus. American Journal of Physiology. Endocrinology and Metabolism. 278: E421-9. PMID 10710496 DOI: 10.1152/Ajpendo.2000.278.3.E421  0.467
2000 Gupta G, She L, Ma XH, Yang XM, Hu M, Cases JA, Vuguin P, Rossetti L, Barzilai N. Aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R111-7. PMID 10644628 DOI: 10.1152/Ajpregu.2000.278.1.R111  0.473
1999 Hawkins M, Hu M, Yu J, Eder H, Vuguin P, She L, Barzilai N, Leiser M, Backer JM, Rossetti L. Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity Journal of Biological Chemistry. 274: 31312-31319. PMID 10531330 DOI: 10.1074/Jbc.274.44.31312  0.577
1999 Barzilai N, She L, Liu L, Wang J, Hu M, Vuguin P, Rossetti L. Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action. The American Journal of Physiology. 277: E291-8. PMID 10444425 DOI: 10.1152/Ajpendo.1999.277.2.E291  0.544
1999 Wang J, Liu R, Liu L, Chowdhury R, Barzilai N, Tan J, Rossetti L. The effect of leptin on Lep expression is tissue-specific and nutritionally regulated. Nature Medicine. 5: 895-9. PMID 10426312 DOI: 10.1038/11335  0.325
1999 Tsao TS, Stenbit AE, Factor SM, Chen W, Rossetti L, Charron MJ. Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle Diabetes. 48: 775-782. PMID 10102694 DOI: 10.2337/Diabetes.48.4.775  0.484
1999 Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, Rossetti L. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes. 48: 94-8. PMID 9892227 DOI: 10.2337/Diabetes.48.1.94  0.603
1998 Liu L, Karkanias GB, Morales JC, Hawkins M, Barzilai N, Wang J, Rossetti L. Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. The Journal of Biological Chemistry. 273: 31160-7. PMID 9813020 DOI: 10.1074/Jbc.273.47.31160  0.593
1998 Kahn BB, Rossetti L. Type 2 diabetes--who is conducting the orchestra? Nature Genetics. 20: 223-5. PMID 9806535 DOI: 10.1038/3018  0.569
1998 Fleischer N, Chen C, Surana M, Leiser M, Rossetti L, Pralong W, Efrat S. Functional analysis of a conditionally transformed pancreatic beta-cell line. Diabetes. 47: 1419-25. PMID 9726230 DOI: 10.2337/Diabetes.47.9.1419  0.365
1998 Mevorach M, Giacca A, Aharon Y, Hawkins M, Shamoon H, Rossetti L. Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus. The Journal of Clinical Investigation. 102: 744-53. PMID 9710443 DOI: 10.1172/Jci2720  0.567
1998 Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature. 393: 684-8. PMID 9641678 DOI: 10.1038/31474  0.374
1998 Barzilai N, Banerjee S, Hawkins M, Chen W, Rossetti L. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. The Journal of Clinical Investigation. 101: 1353-61. PMID 9525977 DOI: 10.1172/Jci485  0.543
1998 Barzilai N, Banerjee S, Hawkins M, Chang CJ, Chen W, Rossetti L. The effect of age-dependent increase in fat mass on peripheral insulin action is saturable. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 53: B141-6. PMID 9520910 DOI: 10.1093/Gerona/53A.2.B141  0.542
1998 Massillon D, Chen W, Barzilai N, Prus-Wertheimer D, Hawkins M, Liu R, Taub R, Rossetti L. Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats. The Journal of Biological Chemistry. 273: 228-34. PMID 9417069 DOI: 10.1074/Jbc.273.1.228  0.384
1998 Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L. Leptin selectively decreases visceral adiposity and enhances insulin action. The Journal of Clinical Investigation. 100: 3105-10. PMID 9399957 DOI: 10.1172/Jci119865  0.583
1997 Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S. Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. American Journal of Physiology. Endocrinology and Metabolism. 273: E743-E750. PMID 29585232 DOI: 10.1152/Ajpendo.1997.273.4.E743  0.551
1997 Rossetti L, Massillon D, Barzilai N, Vuguin P, Chen W, Hawkins M, Wu J, Wang J. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. The Journal of Biological Chemistry. 272: 27758-63. PMID 9346919 DOI: 10.1074/Jbc.272.44.27758  0.607
1997 Gulli G, Rossetti L, DeFronzo RA. Hyperamylinemia is associated with hyperinsulinemia in the glucose-tolerant, insulin-resistant offspring of two Mexican-American non-insulin-dependent diabetic parents. Metabolism: Clinical and Experimental. 46: 1157-61. PMID 9322799 DOI: 10.1016/S0026-0495(97)90209-2  0.594
1997 Rossetti L, Stenbit AE, Chen W, Hu M, Barzilai N, Katz EB, Charron MJ. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene Journal of Clinical Investigation. 100: 1831-1839. PMID 9312184 DOI: 10.1172/Jci119711  0.591
1997 Hawkins M, Barzilai N, Liu R, Hu M, Chen W, Rossetti L. Role of the glucosamine pathway in fat-induced insulin resistance. The Journal of Clinical Investigation. 99: 2173-82. PMID 9151789 DOI: 10.1172/Jci119390  0.535
1997 Hawkins M, Angelov I, Liu R, Barzilai N, Rossetti L. The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake. The Journal of Biological Chemistry. 272: 4889-95. PMID 9030547 DOI: 10.1074/Jbc.272.8.4889  0.539
1997 Farrace S, Frontoni S, Gambardella S, Menzinger G, Rossetti L. Effects of beta-adrenergic blockade on insulin-mediated glucose disposal in hypertensive and normotensive rats. Journal of Hypertension. 14: 1087-92. PMID 8986908 DOI: 10.1097/00004872-199609000-00007  0.466
1997 Massillon D, Barzilai N, Hawkins M, Prus-Wertheimer D, Rossetti L. Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion. Diabetes. 46: 153-7. PMID 8971097 DOI: 10.2337/Diab.46.1.153  0.581
1997 Banerjee S, Saenger P, Chen W, Rossetti L, Barzilai N. Prevention of Fat Accretion through Puberty restores Insulin Action on Glycogen Synthesis to Prepubertal Levels in Conscious Rats. † 373 Pediatric Research. 41: 65-65. DOI: 10.1203/00006450-199704001-00393  0.519
1996 Hawkins M, Barzilai N, Chen W, Angelov I, Hu M, Cohen P, Rossetti L. Increased hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal. Diabetes. 45: 1734-43. PMID 8922359 DOI: 10.2337/Diab.45.12.1734  0.556
1996 Barzilai N, Hawkins M, Angelov I, Hu M, Rossetti L. Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Diabetes. 45: 1329-35. PMID 8826967 DOI: 10.2337/Diab.45.10.1329  0.551
1996 Cohen N, Halberstam M, Rossetti L, Shamoon H. Increased lipid oxidation but normal muscle glycogen response to epinephrine in humans with IDDM. The American Journal of Physiology. 271: E284-93. PMID 8770022 DOI: 10.1152/Ajpendo.1996.271.2.E284  0.543
1996 Moore MC, Rossetti L, Pagliassotti MJ, Monahan M, Venable C, Neal D, Cherrington AD. Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis. The American Journal of Physiology. 271: E215-22. PMID 8770013 DOI: 10.1152/Ajpendo.1996.271.2.E215  0.539
1996 Barzilai N, Rossetti L. Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats. The American Journal of Physiology. 270: E930-6. PMID 8764175 DOI: 10.1152/Ajpendo.1996.270.6.E930  0.597
1996 Massillon D, Barzilai N, Chen W, Hu M, Rossetti L. Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. The Journal of Biological Chemistry. 271: 9871-4. PMID 8626617 DOI: 10.1074/Jbc.271.17.9871  0.584
1996 Halberstam M, Cohen N, Shlimovich P, Rossetti L, Shamoon H. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes. 45: 659-66. PMID 8621019 DOI: 10.2337/Diab.45.5.659  0.551
1996 Massillon D, Chen W, Hawkins M, Liu R, Barzilai N, Rossetti L. Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice. The American Journal of Physiology. 269: E1037-43. PMID 8572194 DOI: 10.1152/Ajpendo.1995.269.6.E1037  0.506
1996 Rossetti L, Barzilai N, Chen W, Harris T, Yang D, Rogler CE. Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious mice. The Journal of Biological Chemistry. 271: 203-8. PMID 8550560 DOI: 10.1074/Jbc.271.1.203  0.541
1996 Farrace S, Frontoni S, Gambardella S, Menzinger G, Rossetti L. Glycogen synthase activity in two rat models of hypertension. American Journal of Hypertension. 8: 949-53. PMID 8541012 DOI: 10.1016/0895-7061(95)00266-R  0.547
1995 Cohen N, Halberstam M, Shlimovich P, Chang CJ, Shamoon H, Rossetti L. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation. 95: 2501-2509. PMID 7769096 DOI: 10.1172/Jci117951  0.561
1995 Cohen N, Rossetti L, Shlimovich P, Halberstam M, Hu M, Shamoon H. Counterregulation of hypoglycemia. Skeletal muscle glycogen metabolism during three hours of physiological hyperinsulinemia in humans. Diabetes. 44: 423-30. PMID 7698511 DOI: 10.2337/Diab.44.4.423  0.505
1995 Bali D, Svetlanov A, Lee HW, Fusco-DeMane D, Leiser M, Li B, Barzilai N, Surana M, Hou H, Fleischer N, DePinho R, Rossetti L, Efrat S. Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene Journal of Biological Chemistry. 270: 21464-21467. PMID 7665557 DOI: 10.1074/Jbc.270.37.21464  0.575
1995 Rossetti L, Hawkins M, Chen W, Gindi J, Barzilai N. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. The Journal of Clinical Investigation. 96: 132-40. PMID 7615783 DOI: 10.1172/Jci118013  0.551
1995 Barzilai N, Massillon D, Rossetti L. Effects of fasting on hepatic and peripheral glucose metabolism in conscious rats with near-total fat depletion. The Biochemical Journal. 819-26. PMID 7575414 DOI: 10.1042/Bj3100819  0.57
1995 Barzilai N, Rossetti L. Relationship between changes in body composition and insulin responsiveness in models of the aging rat. The American Journal of Physiology. 269: E591-7. PMID 7573438 DOI: 10.1152/Ajpendo.1995.269.3.E591  0.514
1994 Rossetti L, Hu M. Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation. Relation to the insulin-mediated inhibition of hepatic glucose production. The Journal of Clinical Investigation. 92: 2963-74. PMID 8254050 DOI: 10.1172/Jci116919  0.585
1994 Shamoon H, Friedman S, Canton C, Zacharowicz L, Hu M, Rossetti L. Increased epinephrine and skeletal muscle responses to hypoglycemia in non-insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 93: 2562-71. PMID 8200993 DOI: 10.1172/Jci117267  0.539
1994 Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. The Journal of Clinical Investigation. 93: 2438-46. PMID 8200979 DOI: 10.1172/Jci117252  0.591
1993 Rossetti L, Farrace S, Choi SB, Giaccari A, Sloan L, Frontoni S, Katz MS. Multiple metabolic effects of CGRP in conscious rats: role of glycogen synthase and phosphorylase. The American Journal of Physiology. 264: E1-10. PMID 8430777 DOI: 10.1152/Ajpendo.1993.264.1.E1  0.567
1993 Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. The Journal of Clinical Investigation. 92: 1126-34. PMID 8397219 DOI: 10.1172/Jci116681  0.559
1993 Rossetti L, Lee YT, Ruiz J, Aldridge SC, Shamoon H, Boden G. Quantitation of glycolysis and skeletal muscle glycogen synthesis in humans. The American Journal of Physiology. 265: E761-9. PMID 8238503 DOI: 10.1152/Ajpendo.1993.265.5.E761  0.467
1993 Moore MC, Shulman GI, Giaccari A, Pagliassotti MJ, Cline G, Neal D, Rossetti L, Cherrington AD. Effect of hepatic nerves on disposition of an intraduodenal glucose load. The American Journal of Physiology. 265: E487-96. PMID 8214056 DOI: 10.1152/Ajpendo.1993.265.3.E487  0.492
1992 Frontoni S, Ohman L, Haywood JR, Rossetti L. Increased insulin sensitivity in the high sodium one-kidney, one figure-8 hypertensive rat. Hypertension. 20: 192-8. PMID 1639460 DOI: 10.1161/01.Hyp.20.2.192  0.543
1992 Frontoni S, Ohman L, Haywood JR, DeFronzo RA, Rossetti L. In vivo insulin action in genetic models of hypertension. The American Journal of Physiology. 262: E191-6. PMID 1539644 DOI: 10.1152/Ajpendo.1992.262.2.E191  0.533
1992 Giaccari A, Rossetti L. Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. The Journal of Clinical Investigation. 89: 36-45. PMID 1530852 DOI: 10.1172/Jci115583  0.536
1992 Farrace S, Rossetti L. Hyperglycemia markedly enhances skeletal muscle glycogen synthase activity in diabetic, but not in normal conscious rats. Diabetes. 41: 1453-63. PMID 1397721 DOI: 10.2337/Diab.41.11.1453  0.593
1991 Kahn BB, Rossetti L, Lodish HF, Charron MJ. Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats Journal of Clinical Investigation. 87: 2197-2206. PMID 2040701 DOI: 10.1172/Jci115254  0.514
1991 Shulman GI, DeFronzo RA, Rossetti L. Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion American Journal of Physiology - Endocrinology and Metabolism. 260. PMID 2035629 DOI: 10.1152/Ajpendo.1991.260.5.E731  0.367
1991 Frontoni S, Choi SB, Banduch D, Rossetti L. In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle. Diabetes. 40: 568-73. PMID 2022302 DOI: 10.2337/Diab.40.5.568  0.59
1991 Rossetti L, Frontoni S, Dimarchi R, DeFronzo RA, Giaccari A. Metabolic effects of IGF-I in diabetic rats Diabetes. 40: 444-448. PMID 2010044 DOI: 10.2337/Diab.40.4.444  0.59
1991 Choi SB, Frontoni S, Rossetti L. Mechanism by which calcitonin gene-related peptide antagonizes insulin action in vivo American Journal of Physiology - Endocrinology and Metabolism. 260. PMID 1996634 DOI: 10.1152/Ajpendo.1991.260.2.E321  0.503
1991 Kahn BB, Shulman GI, DeFronzo RA, Cushman SW, Rossetti L. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. The Journal of Clinical Investigation. 87: 561-70. PMID 1991839 DOI: 10.1172/Jci115031  0.597
1990 Giaccari A, Rossetti L. Isocratic high-performance liquid chromatographic determination of the concentration and specific radioactivity of phosphoenolpyruvate and uridine diphosphate glucose in tissue extracts. Journal of Chromatography. 497: 69-78. PMID 2625480 DOI: 10.1016/0378-4347(89)80006-4  0.44
1990 Rossetti L, Giaccari A, Klein-Robbenhaar E, Vogel LR. Insulinomimetic properties of trace elements and characterization of their in vivo mode of action. Diabetes. 39: 1243-50. PMID 2210077 DOI: 10.2337/Diab.39.10.1243  0.491
1990 Rossetti L, Giaccari A, DeFronzo RA. Glucose toxicity. Diabetes Care. 13: 610-30. PMID 2192847 DOI: 10.2337/diacare.13.6.610  0.498
1990 Rossetti L, Giaccari A. Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats. The Journal of Clinical Investigation. 85: 1785-92. PMID 2189891 DOI: 10.1172/Jci114636  0.607
1990 Rossetti L, DeFronzo RA, Gherzi R, Stein P, Andraghetti G, Falzetti G, Shulman GI, Klein-Robbenhaar E, Cordera R. Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations. Metabolism: Clinical and Experimental. 39: 425-35. PMID 2157941 DOI: 10.1016/0026-0495(90)90259-F  0.583
1990 Cordera R, Andraghetti G, DeFronzo RA, Rossetti L. Effect of in vivo vanadate treatment on insulin receptor tyrosine kinase activity in partially pancreatectomized diabetic rats. Endocrinology. 126: 2177-83. PMID 2156685 DOI: 10.1210/Endo-126-4-2177  0.583
1990 Zawalich WS, Zawalich KC, Shulman GI, Rossetti L. Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets Endocrinology. 126: 253-260. PMID 2152864 DOI: 10.1210/Endo-126-1-253  0.578
1989 Shulman GI, Rossetti L. Influence of the route of glucose administration on hepatic glycogen repletion American Journal of Physiology - Endocrinology and Metabolism. 257. PMID 2688436 DOI: 10.1152/Ajpendo.1989.257.5.E681  0.444
1989 Rossetti L, Rothman DL, DeFronzo RA, Shulman GI. Effect of dietary protein on in vivo insulin action and liver glycogen repletion. The American Journal of Physiology. 257: E212-9. PMID 2669515 DOI: 10.1152/Ajpendo.1989.257.2.E212  0.544
1989 Rossetti L. Normalization of insulin sensitivity with lithium in diabetic rats. Diabetes. 38: 648-52. PMID 2653936 DOI: 10.2337/Diab.38.5.648  0.556
1989 Rossetti L, Laughlin MR. Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle Journal of Clinical Investigation. 84: 892-899. PMID 2503545 DOI: 10.1172/Jci114250  0.478
1988 Smith D, Rossetti L, Ferrannini E, Johnson CM, Cobelli C, Toffolo G, Katz LD, DeFronzo RA. In vivo glucose metabolism in the awake rat: tracer and insulin clamp studies. Metabolism: Clinical and Experimental. 36: 1167-74. PMID 3316926 DOI: 10.1016/0026-0495(87)90244-7  0.596
1987 Camagna A, Rossetti L, Pirro RD, Franco MD, Lauro R, Samoggia P, Caprari P, Salvo G. Characterization of differences in insulin receptors from young and old red blood cells Journal of Endocrinological Investigation. 10: 371-375. PMID 3680872 DOI: 10.1007/Bf03348151  0.498
1987 Shulman GI, Rossetti L, Rothman DL, Blair JB, Smith D. Quantitative analysis of glycogen repletion by nuclear magnetic resonance spectroscopy in the conscious rat. The Journal of Clinical Investigation. 80: 387-93. PMID 3611353 DOI: 10.1172/Jci113084  0.425
1987 Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissues sensitivity to insulin in diabetic rats Journal of Clinical Investigation. 79: 1510-1515. PMID 3571496 DOI: 10.1172/Jci112981  0.549
1987 Rossetti L, Klein-Robbenhaar G, Giebisch G, Smith D, DeFronzo R. Effect of insulin on renal potassium metabolism. The American Journal of Physiology. 252: F60-4. PMID 3544868 DOI: 10.1152/Ajprenal.1987.252.1.F60  0.519
1987 Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats Journal of Clinical Investigation. 80: 1037-1044. PMID 3308956 DOI: 10.1172/Jci113157  0.58
1987 Rossetti L, Shulman GI, Zawalich WS. Physiological role of cholecystokinin in meal-induced insulin secretion in conscious rats. Studies with L 364718, a specific inhibitor of CCK-receptor binding Diabetes. 36: 1212-1215. PMID 3308589 DOI: 10.2337/Diab.36.10.1212  0.554
1986 Cordera R, Gherzi R, De Pirro R, Rossetti L, Freidenberg GR, Andraghetti G, Lauro R, Adezati L. Inhibition of insulin and epidermal growth factor (EGF) receptor autophosphorylation by a human polyclonal IgG. Biochemical and Biophysical Research Communications. 132: 991-1000. PMID 3000370 DOI: 10.1016/0006-291X(85)91905-9  0.511
1985 De Pirro R, Rossetti L, Montemurro A, Lauro R, Gammeltoft S, Maddux BA, Goldfine ID. Human autoantibodies directed against the human, but not the rat, insulin receptor. The Journal of Clinical Endocrinology and Metabolism. 61: 986-9. PMID 4044783 DOI: 10.1210/Jcem-61-5-986  0.434
1984 De Pirro R, Roth RA, Rossetti L, Goldfine ID. Characterization of the serum from a patient with insulin resistance and hypoglycemia. Evidence for multiple populations of insulin receptor antibodies with different receptor binding and insulin-mimicking activities. Diabetes. 33: 301-4. PMID 6365664 DOI: 10.2337/Diab.33.3.301  0.494
1983 Camagna A, Pirro RD, Tardella L, Rossetti L, Lauro R, Caprari P, Samoggia P, Salvo G. Red Blood Cell Age, Pyruvate Kinase Activity, and Insulin Receptors: Evidence that Monocytes and RBCs May Behave Differently Diabetes. 32: 1017-1022. PMID 6642085 DOI: 10.2337/Diab.32.11.1017  0.454
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