Wayne Bowen, Ph.D. - Publications

Molecular Pharmacology, Physiology & Biotechnology Brown University, Providence, RI 
Sigma receptors, pharmacology

128 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Nicholson H, Mesangeau C, McCurdy CR, Bowen WD. Sigma-2 receptors play a role in cellular metabolism: Stimulation of glycolytic hallmarks by CM764 in human SK-N-SH neuroblastoma. The Journal of Pharmacology and Experimental Therapeutics. PMID 26574517 DOI: 10.1124/Jpet.115.228387  1
2015 Nicholson H, Comeau A, Mesangeau C, McCurdy CR, Bowen WD. Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. The Journal of Pharmacology and Experimental Therapeutics. 354: 203-12. PMID 26034081 DOI: 10.1124/Jpet.115.224105  1
2009 Wei Z, Qi J, Dai Y, Bowen WD, Mousseau DD. Haloperidol disrupts Akt signalling to reveal a phosphorylation-dependent regulation of pro-apoptotic Bcl-XS function. Cellular Signalling. 21: 161-8. PMID 18951975 DOI: 10.1016/j.cellsig.2008.10.005  1
2008 Wu Z, Bowen WD. Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells. The Journal of Biological Chemistry. 283: 28198-215. PMID 18539593 DOI: 10.1074/jbc.M802099200  1
2007 Kittler R, Pelletier L, Heninger AK, Slabicki M, Theis M, Miroslaw L, Poser I, Lawo S, Grabner H, Kozak K, Wagner J, Surendranath V, Richter C, Bowen W, Jackson AL, et al. Genome-scale RNAi profiling of cell division in human tissue culture cells. Nature Cell Biology. 9: 1401-12. PMID 17994010 DOI: 10.1038/Ncb1659  1
2007 Martin-Fardon R, Maurice T, Aujla H, Bowen WD, Weiss F. Differential effects of sigma1 receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1967-73. PMID 17268407 DOI: 10.1038/Sj.Npp.1301323  1
2007 Bowen WD. σ2 Receptors: Regulation of cell growth and implications for cancer diagnosis and therapeutics Sigma Receptors: Chemistry, Cell Biology and Clinical Implications. 215-235. DOI: 10.1007/978-0-387-36514-5_11  1
2007 Matsumoto RR, Bowen WD, Su TP. Preface Sigma Receptors: Chemistry, Cell Biology and Clinical Implications. xi. DOI: 10.1007/978-0-387-36514-5  1
2006 Bowen W. An interview with Wayne Bowen, Ph.D. Interview by Vicki Glaser. Assay and Drug Development Technologies. 4: 111-7. PMID 16712415 DOI: 10.1089/adt.2006.4.111  1
2005 Lang SLC, Iverson SJ, Bowen WD. Individual variation in milk composition over lactation in harbour seals (Phoca vitulina) and the potential consequences of intermittent attendance Canadian Journal of Zoology. 83: 1525-1531. DOI: 10.1139/z05-149  1
2004 Gebreselassie D, Bowen WD. Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes. European Journal of Pharmacology. 493: 19-28. PMID 15189760 DOI: 10.1016/j.ejphar.2004.04.005  1
2004 Matsumoto RR, Gilmore DL, Pouw B, Bowen WD, Williams W, Kausar A, Coop A. Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice. European Journal of Pharmacology. 492: 21-6. PMID 15145701 DOI: 10.1016/j.ejphar.2004.03.037  1
2004 Matsumoto RR, Potelleret FH, Mack A, Pouw B, Zhang Y, Bowen WD. Structure-activity comparison of YZ-069, a novel sigma ligand, and four analogs in receptor binding and behavioral studies. Pharmacology, Biochemistry, and Behavior. 77: 775-81. PMID 15099923 DOI: 10.1016/j.pbb.2004.01.014  1
2004 Romieu P, Meunier J, Garcia D, Zozime N, Martin-Fardon R, Bowen WD, Maurice T. The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming. Psychopharmacology. 175: 154-62. PMID 14985920 DOI: 10.1007/S00213-004-1814-X  1
2004 Holzer W, Brandstätter B, Jäger C, Kaun M, Langer T, Bowen WD. N-(3,4-dichlorobenzyl)azoles - Investigations regarding synthesis, NMR-spectroscopy and affinity towards sigma-1 and sigma-2 receptors Scientia Pharmaceutica. 72: 197-211.  1
2003 Cao J, Kulkarni SS, Husbands SM, Bowen WD, Williams W, Kopajtic T, Katz JL, George C, Newman AH. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Journal of Medicinal Chemistry. 46: 2589-98. PMID 12801223 DOI: 10.1021/Jm030008U  1
2003 Romieu P, Martin-Fardon R, Bowen WD, Maurice T. Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3572-6. PMID 12736327  1
2003 Foster A, Wu H, Chen W, Williams W, Bowen WD, Matsumoto RR, Coop A. 1,4-dibenzylpiperazines possess anticocaine activity. Bioorganic & Medicinal Chemistry Letters. 13: 749-51. PMID 12639573 DOI: 10.1016/S0960-894X(02)01034-X  1
2002 Matsumoto RR, McCracken KA, Pouw B, Zhang Y, Bowen WD. Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides. Neuropharmacology. 42: 1043-55. PMID 12128006 DOI: 10.1016/S0028-3908(02)00056-4  1
2002 Crawford KW, Coop A, Bowen WD. sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells. European Journal of Pharmacology. 443: 207-9. PMID 12044812 DOI: 10.1016/S0014-2999(02)01581-9  1
2002 Maeda DY, Williams W, Kim WE, Thatcher LN, Bowen WD, Coop A. N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents. Bioorganic & Medicinal Chemistry Letters. 12: 497-500. PMID 11814827 DOI: 10.1016/S0960-894X(01)00788-0  1
2002 Crawford KW, Bowen WD. Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Research. 62: 313-22. PMID 11782394  1
2002 Bowen W. A 160 EVRC channel T1 and QoS Proceedings - 2002 International Conference On Third Generation Wireless and Beyond (Key Function of World Wireless Congress). 625-628.  1
2001 Bowen WD. Sigma receptors and iboga alkaloids. The Alkaloids. Chemistry and Biology. 56: 173-91. PMID 11705107  1
2001 Zhang Y, Joseph DB, Bowen WD, Flippen-Anderson JL, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues. Journal of Medicinal Chemistry. 44: 3937-45. PMID 11689080 DOI: 10.1021/Jm0101592  1
2001 Matsumoto RR, Hewett KL, Pouw B, Bowen WD, Husbands SM, Cao JJ, Hauck Newman A. Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology. 41: 878-86. PMID 11684152 DOI: 10.1016/S0028-3908(01)00116-2  1
2001 Matsumoto RR, McCracken KA, Friedman MJ, Pouw B, De Costa BR, Bowen WD. Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice. European Journal of Pharmacology. 419: 163-74. PMID 11426838 DOI: 10.1016/S0014-2999(01)00968-2  1
2001 Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR. N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice. European Journal of Pharmacology. 411: 261-73. PMID 11164383 DOI: 10.1016/S0014-2999(00)00917-1  1
2001 Bowen W. Extensible air protocol supporting voice or data in 2G/3G/4G systems Proceedings - 2001 International Conference On Third Generation Wireless and Beyond. 455-459.  1
2000 Bowen WD. Sigma receptors: recent advances and new clinical potentials. Pharmaceutica Acta Helvetiae. 74: 211-8. PMID 10812960 DOI: 10.1016/S0031-6865(99)00034-5  1
2000 Vilner BJ, Bowen WD. Modulation of cellular calcium by sigma-2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells. The Journal of Pharmacology and Experimental Therapeutics. 292: 900-11. PMID 10688603  1
2000 Maeda DY, Williams W, Bowen WD, Coop A. A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding assays. Bioorganic & Medicinal Chemistry Letters. 10: 17-8. PMID 10636233 DOI: 10.1016/S0960-894X(99)00590-9  1
1999 Kedjouar B, Daunes S, Vilner BJ, Bowen WD, Klaebe A, Faye JC, Poirot M. Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor. Biochemical Pharmacology. 58: 1927-39. PMID 10591147 DOI: 10.1016/S0006-2952(99)00285-3  1
1999 Carroll FI, Bai X, Dehghani A, Mascarella SW, Williams W, Bowen WD. Asymmetric synthesis of 9-alkyl-2-benzyl-6,7-benzomorphans: characterization as novel sigma receptor ligands. Journal of Medicinal Chemistry. 42: 4621-9. PMID 10579824 DOI: 10.1021/jm990169r  1
1999 Husbands SM, Izenwasser S, Kopajtic T, Bowen WD, Vilner BJ, Katz JL, Newman AH. Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. Journal of Medicinal Chemistry. 42: 4446-55. PMID 10543888 DOI: 10.1021/Jm9902943  1
1999 John CS, Vilner BJ, Geyer BC, Moody T, Bowen WD. Targeting sigma receptor-binding benzamides as in vivo diagnostic and therapeutic agents for human prostate tumors. Cancer Research. 59: 4578-83. PMID 10493511  1
1999 Ambs SM, Boness DJ, Bowen WD, Perry EA, Fleischer RC. Proximate factors associated with high levels of extraconsort fertilization in polygynous grey seals. Animal Behaviour. 58: 527-535. PMID 10479368 DOI: 10.1006/Anbe.1999.1201  1
1999 John CS, Bowen WD, Fisher SJ, Lim BB, Geyer BC, Vilner BJ, Wahl RL. Synthesis, in vitro pharmacologic characterization, and preclinical evaluation of N-[2-(1'-piperidinyl)ethyl]-3-[125I]iodo-4-methoxybenzamide (P[125I]MBA) for imaging breast cancer. Nuclear Medicine and Biology. 26: 377-82. PMID 10382840 DOI: 10.1016/S0969-8051(98)00104-8  1
1999 Matsumoto RR, Bowen WD, de Costa BR, Houk JC. Relationship between modulation of the cerebellorubrospinal system in the in vitro turtle brain and changes in motor behavior in rats: effects of novel sigma ligands. Brain Research Bulletin. 48: 497-508. PMID 10372510 DOI: 10.1016/S0361-9230(99)00029-5  1
1999 McCracken KA, Bowen WD, de Costa BR, Matsumoto RR. Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. European Journal of Pharmacology. 370: 225-32. PMID 10334496 DOI: 10.1016/S0014-2999(99)00113-2  1
1999 McCracken KA, Bowen WD, Matsumoto RR. Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine. European Journal of Pharmacology. 365: 35-8. PMID 9988120 DOI: 10.1016/S0014-2999(98)00876-0  1
1999 Grahl-Nielsen O, Smith SJ, Iverson SJ, Bowen WD. Comment: Fatty acid signatures and classification trees: New tools for investigating the foraging ecology of seals Canadian Journal of Fisheries and Aquatic Sciences. 56: 2219-2226.  1
1999 John CS, Lim BB, Vilner BJ, Bowen WD. Substituted N-(Benzyl)-N-methyl-2-(1-piperidinyl)ethylamine (BME) and its analogs as new sigma receptor markers: Synthesis, characterization, and in-vivo evaluation Journal of Labelled Compounds and Radiopharmaceuticals. 42: S411-S413.  1
1998 Zhang Y, Williams W, Torrence-Campbell C, Bowen WD, Rice KC. Characterization of novel N,N'-disubstituted piperazines as sigma receptor ligands. Journal of Medicinal Chemistry. 41: 4950-7. PMID 9836612 DOI: 10.1021/Jm980143K  1
1998 Novakova M, Ela C, Bowen WD, Hasin Y, Eilam Y. Highly selective sigma receptor ligands elevate inositol 1,4,5-trisphosphate production in rat cardiac myocytes. European Journal of Pharmacology. 353: 315-27. PMID 9726662 DOI: 10.1016/S0014-2999(98)00398-7  1
1998 John CS, Lim BB, Vilner BJ, Geyer BC, Bowen WD. Substituted halogenated arylsulfonamides: a new class of sigma receptor binding tumor imaging agents. Journal of Medicinal Chemistry. 41: 2445-50. PMID 9651150 DOI: 10.1021/jm9800447  1
1998 Coltman DW, Bowen WD, Wright JM. Birth weight and neonatal survival of harbour seal pups are positively correlated with genetic variation measured by microsatellites. Proceedings. Biological Sciences / the Royal Society. 265: 803-9. PMID 9628038 DOI: 10.1098/Rspb.1998.0363  1
1998 John CS, Gulden ME, Li J, Bowen WD, McAfee JG, Thakur ML. Synthesis, in vitro binding, and tissue distribution of radioiodinated 2-[125I]N-(N-benzylpiperidin-4-yl)-2-iodo benzamide, 2-[125I]BP: a potential sigma receptor marker for human prostate tumors. Nuclear Medicine and Biology. 25: 189-94. PMID 9620622 DOI: 10.1016/S0969-8051(97)00168-6  1
1998 Helsley S, Filipink RA, Bowen WD, Rabin RA, Winter JC. The effects of sigma, PCP, and opiate receptor ligands in rats trained with ibogaine as a discriminative stimulus. Pharmacology, Biochemistry, and Behavior. 59: 495-503. PMID 9477000 DOI: 10.1016/S0091-3057(97)00454-1  1
1997 Husbands SM, Izenwasser S, Loeloff RJ, Katz JL, Bowen WD, Vilner BJ, Newman AH. Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter. Journal of Medicinal Chemistry. 40: 4340-46. PMID 9435903 DOI: 10.1021/Jm9705519  1
1997 Dence CS, John CS, Bowen WD, Welch MJ. Synthesis and evaluation of [18F] labeled benzamides: high affinity sigma receptor ligands for PET imaging. Nuclear Medicine and Biology. 24: 333-40. PMID 9257332 DOI: 10.1016/S0969-8051(97)00001-2  1
1997 John CS, Lim BB, Geyer BC, Vilner BJ, Bowen WD. 99mTc-labeled sigma-receptor-binding complex: synthesis, characterization, and specific binding to human ductal breast carcinoma (T47D) cells. Bioconjugate Chemistry. 8: 304-9. PMID 9177835 DOI: 10.1021/bc9700087  1
1997 Chien CC, Carroll FI, Brown GP, Pan YX, Bowen W, Pasternak GW. Synthesis and characterization of [125I]3'-(-)-iodopentazocine, a selective sigma 1 receptor ligand. European Journal of Pharmacology. 321: 361-8. PMID 9085049 DOI: 10.1016/S0014-2999(96)00963-6  1
1997 Kline RH, Izenwasser S, Katz JL, Joseph DB, Bowen WD, Newman AH. 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. Journal of Medicinal Chemistry. 40: 851-7. PMID 9083473 DOI: 10.1021/Jm950782K  1
1996 Coltman DW, Bowen WD, Wright JM. PCR primers for harbour seal (Phoca vitulina concolour) microsatellites amplify polymorphic loci in other pinniped species. Molecular Ecology. 5: 161-3. PMID 9147692  1
1996 John CS, Gulden ME, Vilner BJ, Bowen WD. Synthesis, in vitro validation and in vivo pharmacokinetics of [125I]N-[2-(4-iodophenyl)ethyl]-N-methyl-2-(1-piperidinyl) ethylamine: a high-affinity ligand for imaging sigma receptor positive tumors. Nuclear Medicine and Biology. 23: 761-6. PMID 8940718 DOI: 10.1016/0969-8051(96)00070-4  1
1996 Monnet FP, de Costa BR, Bowen WD. Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. British Journal of Pharmacology. 119: 65-72. PMID 8872358  1
1996 Torrence-Campbell C, Bowen WD. Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions. European Journal of Pharmacology. 304: 201-10. PMID 8813603 DOI: 10.1016/0014-2999(96)00109-4  1
1996 Zhang Y, Williams W, Bowen WD, Rice KC. Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity. Journal of Medicinal Chemistry. 39: 3564-8. PMID 8784455 DOI: 10.1021/Jm9600813  1
1996 Matsumoto RR, Bowen WD, Walker JM, Patrick SL, Zambon AC, Vo VN, Truong DD, De Costa BR, Rice KC. Dissociation of the motor effects of (+)-pentazocine from binding to sigma 1 sites. European Journal of Pharmacology. 301: 31-40. PMID 8773444 DOI: 10.1016/0014-2999(96)00008-8  1
1996 Mohn R, Bowen WD. Grey seal predation on the eastern Scotian Shelf: modelling the impact on Atlantic cod Canadian Journal of Fisheries and Aquatic Sciences. 53: 2722-2738.  1
1996 Bonnes DJ, Bowen WD. The evolution of material care in Pinnipeds Bioscience. 46: 645-654.  1
1996 Bowen WD, Harrison GD. Comparison of harbour seal diets in two inshore habitats of Atlantic Canada Canadian Journal of Zoology. 74: 125-135.  1
1995 Iverson SJ, Hamosh M, Bowen WD. Lipoprotein lipase activity and its relationship to high milk fat transfer during lactation in grey seals Journal of Comparative Physiology B. 165: 384-395. PMID 8576451 DOI: 10.1007/BF00387309  1
1995 Matsumoto RR, Bowen WD, Tom MA, Vo VN, Truong DD, De Costa BR. Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism European Journal of Pharmacology. 280: 301-310. PMID 8566098 DOI: 10.1016/0014-2999(95)00208-3  1
1995 Mascarella SW, Bai X, Williams W, Sine B, Bowen WD, Carroll FI. (+)-cis-N-(para-, meta-, and ortho-substituted benzyl)-N-normetazocines: Synthesis and binding affinity at the [3H]-(+)-pentazocine-labeled (σ1) site and quantitative structure-affinity relationship studies Journal of Medicinal Chemistry. 38: 565-569. PMID 7853349  1
1995 Vilner BJ, De Costa BR, Bowen WD. Cytotoxic effects of sigma ligands: Sigma receptor-mediated alterations in cellular morphology and viability Journal of Neuroscience. 15: 117-134. PMID 7823122 DOI: 10.1523/Jneurosci.15-01-00117.1995  1
1995 Vilner BJ, John CS, Bowen WD. Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. Cancer Research. 55: 408-13. PMID 7812973  1
1995 John CS, Bowen WD, Varma VM, McAfee JG, Moody TW. Sigma receptors are expressed in human non-small cell lung carcinoma. Life Sciences. 56: 2385-92. PMID 7791525 DOI: 10.1016/0024-3205(95)00232-U  1
1995 Danso-Danquah R, Bai X, Zhang X, Mascarella SW, Williams W, Sine B, Bowen WD, Carroll FI. Synthesis and sigma binding properties of 1'- and 3'-halo- and 1',3'-dihalo-N-normetazocine analogues. Journal of Medicinal Chemistry. 38: 2986-9. PMID 7636861  1
1995 Danso-Danquah R, Bai X, Zhang X, Mascarella SW, Williams W, Sine B, Bowen WD, Carroll FI. Synthesis and sigma binding properties of 2'-substituted 5,9 alpha-dimethyl-6,7-benzomorphans. Journal of Medicinal Chemistry. 38: 2978-85. PMID 7636860  1
1995 Cole JL, Leventhal L, Pasternak GW, Bowen WD, Bodnar RJ. Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats. Brain Research. 678: 168-76. PMID 7620885 DOI: 10.1016/0006-8993(95)00181-O  1
1995 John CS, Vilner BJ, Gulden ME, Efange SM, Langason RB, Moody TW, Bowen WD. Synthesis and pharmacological characterization of 4-[125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide: a high affinity sigma receptor ligand for potential imaging of breast cancer. Cancer Research. 55: 3022-7. PMID 7606722  1
1995 Iverson SJ, Oftedal OT, Bowen WD, Boness DJ, Sampugna J. Prenatal and postnatal transfer of fatty acids from mother to pup in the hooded seal Journal of Comparative Physiology B. 165: 1-12. PMID 7601954 DOI: 10.1007/Bf00264680  1
1995 Bowen WD, Bertha CM, Vilner BJ, Rice KC. CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity. European Journal of Pharmacology. 278: 257-60. PMID 7589164 DOI: 10.1016/0014-2999(95)00176-L  1
1995 Bowen WD, Vilner BJ, Williams W, Bertha CM, Kuehne ME, Jacobson AE. Ibogaine and its congeners are σ2 receptor-selective ligands with moderate affinity European Journal of Pharmacology. 279: R1-R3. PMID 7556375 DOI: 10.1016/0014-2999(95)00247-I  1
1995 Bertha CM, Vilner BJ, Mattson MV, Bowen WD, Becketts K, Xu H, Rothman RB, Flippen-Anderson JL, Rice KC. (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype. Journal of Medicinal Chemistry. 38: 4776-85. PMID 7490727 DOI: 10.1021/Jm00024A005  1
1995 Boness DJ, Bowen WD, Iverson SJ. Does male harassment of females contribute to reproductive synchrony in the grey seal by affecting maternal performance? Behavioral Ecology and Sociobiology. 36: 1-10. DOI: 10.1007/BF00175722  1
1994 De Costa BR, He XS, Dominguez C, Cutts J, Williams W, Bowen WD. A New Approach to the Design of σ-2-Selective Ligands: Synthesis and Evaluation of N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine-Related Polyamines at σ-1 and σ-2 Receptor Subtypes Journal of Medicinal Chemistry®. 37: 314-321. PMID 8295220 DOI: 10.1021/jm00028a016  1
1994 Miyamoto Y, Bowen WD, Portoghese PS, Takemori AE. Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice. The Journal of Pharmacology and Experimental Therapeutics. 270: 37-9. PMID 8035333  1
1994 John CS, Vilner BJ, Bowen WD. Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells. Journal of Medicinal Chemistry. 37: 1737-9. PMID 8021913  1
1994 Hellewell SB, Bruce A, Feinstein G, Orringer J, Williams W, Bowen WD. Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling European Journal of Pharmacology: Molecular Pharmacology. 268: 9-18. PMID 7925616 DOI: 10.1016/0922-4106(94)90115-5  1
1994 Ross PS, de Swart RL, Visser IKG, Vedder LJ, Murk W, Bowen WD, Osterhaus ADME. Relative immunocompetence of the newborn harbour seal, Phoca vitulina Veterinary Immunology and Immunopathology. 42: 331-348. PMID 7810064 DOI: 10.1016/0165-2427(94)90077-9  1
1994 Bai X, Mascarella SW, Bowen WD, Carroll FI. A novel asymmetric synthesis of 3-benzyl-1,2,3,4,5,6-hexahydro-11-alkyl-2, 6-methano-3-benzazocines Journal of the Chemical Society, Chemical Communications. 2401-2402. DOI: 10.1039/C39940002401  1
1994 Dehghani A, Bai X, Mascarella SW, Bowen WD, Carroll FI. A novel stereo- and enantioselective synthesis of trans-9-alkyl-2-benzyl-5-methyl-6,7-benzomorphans Tetrahedron Letters. 35: 8969-8972. DOI: 10.1016/0040-4039(94)88402-1  1
1994 Bonessl DJ, Bowen WD, Oftedall OT. Evidence of a maternal foraging cycle resembling that of otariid seals in a small phocid, the harbor seal Behavioral Ecology and Sociobiology. 34: 95-104. DOI: 10.1007/BF00164180  1
1994 Bowen WD, Harrison GD. Offshore diet of grey seals Halichoerus grypus near Sable Island, Canada Marine Ecology Progress Series. 112: 1-12.  1
1994 John CS, Baumgold J, Vilner BJ, McAfee JG, Bowen WD. [125I]N-(2-piperidinylaminoethyl)4-iodobenzamide and related analogs as sigma receptor imaging agents; High affinity binding to human malignant melanoma and rat C6 glioma cell lines Journal of Labelled Compounds and Radiopharmaceuticals. 35: 242-244.  1
1993 He XS, Bowen WD, Lee KS, Williams W, Weinberger DR, De Costa BR. Synthesis and binding characteristics of potential SPECT imaging agents for σ-1 and σ-2 binding sites Journal of Medicinal Chemistry. 36: 566-571. PMID 8496936 DOI: 10.1021/jm00057a006  1
1993 Horan PJ, Wild KD, Kazmierski WM, Ferguson R, Hruby VJ, Weber SJ, Davis TP, Fang L, Knapp RJ, Yamamura HI. Unexpected antinociceptive potency of cyclic [D-Tca1]CTAP: potential for a novel mechanism of action. European Journal of Pharmacology. 233: 53-62. PMID 8386089 DOI: 10.1016/0014-2999(93)90348-L  1
1993 Walker JM, Bowen WD, Patrick SL, Williams WE, Mascarella SW, Bai X, Carroll FI. A comparison of (-)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of sigma 2 receptors in motor function. European Journal of Pharmacology. 231: 61-8. PMID 8383063 DOI: 10.1016/0014-2999(93)90684-A  1
1993 Wild KD, Carlisi VJ, Mosberg HI, Bowen WD, Portoghese PS, Sultana M, Takemori AE, Hruby VJ, Porreca F. Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens. The Journal of Pharmacology and Experimental Therapeutics. 264: 831-8. PMID 8382281  1
1993 De Costa BR, He XS, Linders JTM, Dominguez C, Gu ZQ, Williams W, Bowen WD. Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at σ receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds Journal of Medicinal Chemistry. 36: 2311-2320. PMID 8360875  1
1993 Hemstreet MK, Matsumoto RR, Bowen WD, Walker JM. Sigma binding parameters in developing rats predict behavioral efficacy of a sigma ligand. Brain Research. 627: 291-8. PMID 8298974 DOI: 10.1016/0006-8993(93)90333-I  1
1993 Jones DN, Bowen WD, Portoghese PS, Holtzman SG. Delta-opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine. European Journal of Pharmacology. 249: 167-77. PMID 8287898 DOI: 10.1016/0014-2999(93)90429-L  1
1993 Vilner BJ, Bowen WD. σ Receptor-active neuroleptics are cytotoxic to C6 glioma cells in culture European Journal of Pharmacology: Molecular Pharmacology. 244: 199-201. PMID 8094338 DOI: 10.1016/0922-4106(93)90029-9  1
1993 Oftedal OT, Bowen WD, Boness DJ. Energy transfer by lactating hooded seals and nutrient deposition in their pups during the four days from birth to weaning Physiological Zoology. 66: 412-436.  1
1993 Walker BG, Bowen WD. Changes in body mass and feeding behaviour in male harbour seals, Phoca vitulina, in relation to female reproductive status Journal of Zoology. 231: 423-436.  1
1993 Iverson SJ, Bowen WD, Boness DJ, Oftedal OT. The effect of maternal size and milk energy output on pup growth in grey seals (Halichoerus grypus) Physiological Zoology. 66: 61-88.  1
1993 Walker JM, Bowen WD, Patrick SL, Williams WE, Mascarella SW, Bai X, Carroll FI. A comparison of (-)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of σ2 receptors in motor function European Journal of Pharmacology. 236: 495.  1
1992 Rothman RB, Bykov V, Jacobson AE, Rice KC, Long JE, Bowen WD. A study of the effect of the irreversible delta receptor antagonist [D-Ala2,Leu5,Cys6]-enkephalin on delta cx and delta ncx opioid binding sites in vitro and in vivo. Peptides. 13: 691-4. PMID 1331996 DOI: 10.1016/0196-9781(92)90174-2  1
1992 Walker JM, Bowen WD, Goldstein SR, Roberts AH, Patrick SL, Hohmann AG, DeCosta B. Autoradiographic distribution of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: a comparative study. Brain Research. 581: 33-8. PMID 1323368 DOI: 10.1016/0006-8993(92)90340-F  1
1992 Sahin M, Bowen WD, Donoghue JP. Location of nicotinic and muscarinic cholinergic and mu-opiate receptors in rat cerebral neocortex: evidence from thalamic and cortical lesions. Brain Research. 579: 135-47. PMID 1320443 DOI: 10.1016/0006-8993(92)90752-U  1
1991 Berson DM, Graybiel AM, Bowen WD, Thompson LA. Evidence for intrinsic expression of enkephalin-like immunoreactivity and opioid binding sites in cat superior colliculus. Neuroscience. 43: 513-29. PMID 1922782 DOI: 10.1016/0306-4522(91)90312-C  1
1991 Arjune D, Bowen WD, Bodnar RJ. Ingestive behavior following central [D-Ala2, Leu5, Cys6]-enkephalin (DALCE), a short-acting agonist and long-acting antagonist at the delta opioid receptor. Pharmacology, Biochemistry, and Behavior. 39: 429-36. PMID 1658817 DOI: 10.1016/0091-3057(91)90203-E  1
1991 Mattia A, Vanderah T, Mosberg HI, Omnaas JR, Bowen WD, Porreca F. Pharmacological characterization of [D-Ala2,Leu5,Ser6]enkephalin (DALES): antinociceptive actions at the δnon-complexed-opioid receptor European Journal of Pharmacology. 192: 371-375. PMID 1647317 DOI: 10.1016/0014-2999(91)90227-H  1
1990 De Costa BR, Rice KC, Bowen WD, Thurkauf A, Rothman RB, Band L, Jacobson AE, Radesca L, Contreras PC, Gray NM, Daly I, Iyengar S, Finn DT, Vazirani S, Walker JM. Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity σ receptor ligands. Identification of a new class of highly potent and selective σ receptor probes Journal of Medicinal Chemistry. 33: 3100-3110. PMID 2172538 DOI: 10.1021/jm00173a030  1
1990 Calcagnetti DJ, Bowen WD, Holtzman SG. Stress-induced tolerance to delta receptor agonist DPDPE and selectivity of the irreversible delta-ligand, DALCE. Brain Research. 509: 205-12. PMID 2157520 DOI: 10.1016/0006-8993(90)90545-M  1
1989 Dudek SM, Bowen WD, Bear MF. Postnatal changes in glutamate stimulated phosphoinositide turnover in rat neocortical synaptoneurosomes. Brain Research. Developmental Brain Research. 47: 123-8. PMID 2567641 DOI: 10.1016/0165-3806(89)90114-4  1
1989 Goldstein SR, Matsumoto RR, Thompson TL, Patrick RL, Bowen WD, Walker JM. Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons Synapse. 4: 254-258. PMID 2558420 DOI: 10.1002/Syn.890040311  1
1989 Calcagnetti DJ, Fanselow MS, Helmstetter FJ, Bowen WD. [D-Ala2,Leu5,Cys6]enkephalin: short-term agonist effects and long-term antagonism at delta opioid receptors. Peptides. 10: 319-26. PMID 2547203 DOI: 10.1016/0196-9781(89)90037-5  1
1989 de Costa BR, Bowen WD, Hellewell SB, George C, Rothman RB, Reid AA, Walker JM, Jacobson AE, Rice KC. Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. Journal of Medicinal Chemistry. 32: 1996-2002. PMID 2547074 DOI: 10.1021/jm00128a050  1
1989 Bowen WD, Hellewell SB, McGarry KA. Evidence for a multi-site model of the rat brain σ receptor European Journal of Pharmacology. 163: 309-318. PMID 2542066 DOI: 10.1016/0014-2999(89)90200-8  1
1989 Bluth LS, Rice KC, Jacobson AE, Bowen WD. Acylation of σ receptors by Metaphit, an isothiocyanate derivative of phencyclidine European Journal of Pharmacology. 161: 273-277. PMID 2542047 DOI: 10.1016/0014-2999(89)90859-5  1
1988 Walker JM, Bowen WD, Thompson LA, Frascella J, Lehmkuhle S, Hughes HC. Distribution of opiate receptors within visual structures of the cat brain. Experimental Brain Research. 73: 523-32. PMID 2852119 DOI: 10.1007/BF00406610  1
1988 Bowen WD, Kirschner BK, Newman AH, Rice KC. σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain European Journal of Pharmacology. 149: 399-400. PMID 2842167 DOI: 10.1016/0014-2999(88)90678-4  1
1988 Bowen WD, Walker JM, Yashar AG, Matsumoto RR, Walker FO, Lorden JF. Altered haloperidol-sensitive sigma receptors in the genetically dystonic (dt) rat. European Journal of Pharmacology. 147: 153-4. PMID 2836218 DOI: 10.1016/0014-2999(88)90647-4  1
1987 Walker JM, Coy DH, Young EA, Baldrighi G, Siegel SF, Bowen WD, Akil H. [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN): a potent analog of dynorphin 1-13. Peptides. 8: 811-7. PMID 2893357 DOI: 10.1016/0196-9781(87)90064-7  1
1985 Rothman RB, Bowen WD, Herkenham M, Jacobson AE, Rice KC, Pert CB. A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site. Molecular Pharmacology. 27: 399-409. PMID 2579319  1
1984 Trzaskos JM, Bowen WD, Shafiee A, Fischer RT, Gaylor JL. Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation. The Journal of Biological Chemistry. 259: 13402-12. PMID 6208195  0.48
1984 Rothman RB, Bowen WD, Bykov V, Schumacher UK, Pert CB, Jacobson AE, Burke TR, Rice KC. Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: evidence for a two-site allosteric model. Neuropeptides. 4: 201-15. PMID 6087189 DOI: 10.1016/0143-4179(84)90101-X  1
1983 Rothman RB, Bowen WD, Schumacher UK, Pert CB. Effect of beta-FNA on opiate receptor binding: preliminary evidence for two types of mu receptors. European Journal of Pharmacology. 95: 147-8. PMID 6321203 DOI: 10.1016/0014-2999(83)90282-0  1
1982 Trzaskos JM, Bowen WD, Fisher GJ, Billheimer JT, Gaylor JL. Microsomal enzymes of cholesterol biosynthesis from lanosterol: a progress report. Lipids. 17: 250-6. PMID 6806557 DOI: 10.1007/Bf02535112  1
1982 Quirion R, Bowen WD, Herkenham M, Pert CB. Visualization and solubilization of rat brain opiate receptors with a "kappa" ligand selectivity pattern. Cellular and Molecular Neurobiology. 2: 333-46. PMID 6305502 DOI: 10.1007/Bf00710853  1
1982 Bowen WD, Pert CB, Pert A. Nigral 6-hydroxydopamine lesions equally decrease mu and delta opiate binding to striatal patches: further evidence for a conformationally malleable type 1 opiate receptor. Life Sciences. 31: 1679-82. PMID 6296571 DOI: 10.1016/0024-3205(82)90184-9  0.84
1982 Olgiati V, Quirion R, Bowen WD, Pert CB. Characterization of type 2 opiate receptors. Life Sciences. 31: 1675-8. PMID 6296570 DOI: 10.1016/0024-3205(82)90183-7  0.84
1982 Bowen WD, Pert CB. Conformational malleability of opiate receptors: Sulfhydryl modification alters ion-induced μ/δ-ligand selectivity shifts in rat striatal sections Cellular and Molecular Neurobiology. 2: 115-128. DOI: 10.1007/BF00711077  1
1981 Bowen WD, Gentleman S, Herkenham M, Pert CB. Interconverting mu and delta forms of the opiate receptor in rat striatal patches. Proceedings of the National Academy of Sciences of the United States of America. 78: 4818-22. PMID 6272275 DOI: 10.1073/Pnas.78.8.4818  1
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