| Year |
Citation |
Score |
| 2021 |
Liu CZ, Mottinelli M, Nicholson HE, McVeigh BM, Wong NK, McCurdy CR, Bowen WD. Identification and characterization of MAM03055A: a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity. European Journal of Pharmacology. 174263. PMID 34144027 DOI: 10.1016/j.ejphar.2021.174263 |
0.303 |
|
| 2018 |
Nicholson HE, Alsharif WF, Comeau AB, Mesangeau C, Intagliata S, Mottinelli M, McCurdy CR, Bowen WD. Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-activity Relationships of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives. The Journal of Pharmacology and Experimental Therapeutics. PMID 30530624 DOI: 10.1124/jpet.118.253484 |
0.316 |
|
| 2002 |
Maeda DY, Williams W, Kim WE, Thatcher LN, Bowen WD, Coop A. N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents. Bioorganic & Medicinal Chemistry Letters. 12: 497-500. PMID 11814827 DOI: 10.1016/S0960-894X(01)00788-0 |
0.319 |
|
| 2000 |
Maeda DY, Williams W, Bowen WD, Coop A. A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding assays. Bioorganic & Medicinal Chemistry Letters. 10: 17-8. PMID 10636233 DOI: 10.1016/S0960-894X(99)00590-9 |
0.326 |
|
| 1999 |
Kedjouar B, Daunes S, Vilner BJ, Bowen WD, Klaebe A, Faye JC, Poirot M. Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor. Biochemical Pharmacology. 58: 1927-39. PMID 10591147 DOI: 10.1016/S0006-2952(99)00285-3 |
0.342 |
|
| 1998 |
Helsley S, Filipink RA, Bowen WD, Rabin RA, Winter JC. The effects of sigma, PCP, and opiate receptor ligands in rats trained with ibogaine as a discriminative stimulus. Pharmacology, Biochemistry, and Behavior. 59: 495-503. PMID 9477000 DOI: 10.1016/S0091-3057(97)00454-1 |
0.321 |
|
| 1997 |
John CS, Lim BB, Geyer BC, Vilner BJ, Bowen WD. 99mTc-labeled sigma-receptor-binding complex: synthesis, characterization, and specific binding to human ductal breast carcinoma (T47D) cells. Bioconjugate Chemistry. 8: 304-9. PMID 9177835 DOI: 10.1021/bc9700087 |
0.32 |
|
| 1997 |
Chien CC, Carroll FI, Brown GP, Pan YX, Bowen W, Pasternak GW. Synthesis and characterization of [125I]3'-(-)-iodopentazocine, a selective sigma 1 receptor ligand. European Journal of Pharmacology. 321: 361-8. PMID 9085049 DOI: 10.1016/S0014-2999(96)00963-6 |
0.435 |
|
| 1996 |
Matsumoto RR, Bowen WD, Walker JM, Patrick SL, Zambon AC, Vo VN, Truong DD, De Costa BR, Rice KC. Dissociation of the motor effects of (+)-pentazocine from binding to sigma 1 sites. European Journal of Pharmacology. 301: 31-40. PMID 8773444 DOI: 10.1016/0014-2999(96)00008-8 |
0.306 |
|
| 1995 |
Matsumoto RR, Bowen WD, Tom MA, Vo VN, Truong DD, De Costa BR. Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism European Journal of Pharmacology. 280: 301-310. PMID 8566098 DOI: 10.1016/0014-2999(95)00208-3 |
0.331 |
|
| 1995 |
Vilner BJ, De Costa BR, Bowen WD. Cytotoxic effects of sigma ligands: Sigma receptor-mediated alterations in cellular morphology and viability Journal of Neuroscience. 15: 117-134. PMID 7823122 DOI: 10.1523/Jneurosci.15-01-00117.1995 |
0.362 |
|
| 1992 |
de Costa BR, Dominguez C, He XS, Williams W, Radesca L, Bowen W. Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes. Journal of Medicinal Chemistry. 35: 4334-43. PMID 1447735 DOI: 10.1021/Jm00101A011 |
0.367 |
|
| 1992 |
Rothman RB, Bykov V, Jacobson AE, Rice KC, Long JE, Bowen WD. A study of the effect of the irreversible delta receptor antagonist [D-Ala2,Leu5,Cys6]-enkephalin on delta cx and delta ncx opioid binding sites in vitro and in vivo. Peptides. 13: 691-4. PMID 1331996 DOI: 10.1016/0196-9781(92)90174-2 |
0.34 |
|
| 1985 |
Rothman RB, Bowen WD, Herkenham M, Jacobson AE, Rice KC, Pert CB. A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site. Molecular Pharmacology. 27: 399-409. PMID 2579319 |
0.52 |
|
| 1984 |
Trzaskos JM, Bowen WD, Shafiee A, Fischer RT, Gaylor JL. Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation. The Journal of Biological Chemistry. 259: 13402-12. PMID 6208195 |
0.52 |
|
| 1984 |
Rothman RB, Bowen WD, Bykov V, Schumacher UK, Pert CB, Jacobson AE, Burke TR, Rice KC. Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: evidence for a two-site allosteric model. Neuropeptides. 4: 201-15. PMID 6087189 DOI: 10.1016/0143-4179(84)90101-X |
0.523 |
|
| 1983 |
Rothman RB, Bowen WD, Schumacher UK, Pert CB. Effect of beta-FNA on opiate receptor binding: preliminary evidence for two types of mu receptors. European Journal of Pharmacology. 95: 147-8. PMID 6321203 DOI: 10.1016/0014-2999(83)90282-0 |
0.522 |
|
| 1982 |
Trzaskos JM, Bowen WD, Fisher GJ, Billheimer JT, Gaylor JL. Microsomal enzymes of cholesterol biosynthesis from lanosterol: a progress report. Lipids. 17: 250-6. PMID 6806557 DOI: 10.1007/Bf02535112 |
0.512 |
|
| 1982 |
Quirion R, Bowen WD, Herkenham M, Pert CB. Visualization and solubilization of rat brain opiate receptors with a "kappa" ligand selectivity pattern. Cellular and Molecular Neurobiology. 2: 333-46. PMID 6305502 DOI: 10.1007/Bf00710853 |
0.616 |
|
| 1982 |
Bowen WD, Pert CB, Pert A. Nigral 6-hydroxydopamine lesions equally decrease mu and delta opiate binding to striatal patches: further evidence for a conformationally malleable type 1 opiate receptor. Life Sciences. 31: 1679-82. PMID 6296571 DOI: 10.1016/0024-3205(82)90184-9 |
0.558 |
|
| 1982 |
Olgiati V, Quirion R, Bowen WD, Pert CB. Characterization of type 2 opiate receptors. Life Sciences. 31: 1675-8. PMID 6296570 DOI: 10.1016/0024-3205(82)90183-7 |
0.607 |
|
| 1982 |
Bowen WD, Pert CB. Conformational malleability of opiate receptors: Sulfhydryl modification alters ion-induced μ/δ-ligand selectivity shifts in rat striatal sections Cellular and Molecular Neurobiology. 2: 115-128. DOI: 10.1007/BF00711077 |
0.501 |
|
| 1981 |
Bowen WD, Gentleman S, Herkenham M, Pert CB. Interconverting mu and delta forms of the opiate receptor in rat striatal patches. Proceedings of the National Academy of Sciences of the United States of America. 78: 4818-22. PMID 6272275 DOI: 10.1073/Pnas.78.8.4818 |
0.554 |
|
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