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Jemy A. Gutierrez, Ph.D. - Publications

Affiliations: 
2006 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Biochemistry
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9 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Futatsugi K, Smith AC, Tu M, Raymer B, Ahn K, Coffey SB, Dowling MS, Fernando DP, Gutierrez JA, Huard K, Jasti J, Kalgutkar AS, Knafels JD, Pandit J, Parris KD, et al. Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. Journal of Medicinal Chemistry. PMID 32910646 DOI: 10.1021/Acs.Jmedchem.0C00944  0.324
2017 Huard K, Ahn K, Amor PA, Beebe DA, Borzilleri KA, Chrunyk BA, Coffey SB, Cong Y, Conn EL, Culp JS, Dowling MS, Gorgoglione MF, Gutierrez JA, Knafels JD, Lachapelle EA, et al. Discovery of Fragment-Derived Small Molecules for In Vivo Inhibition of Ketohexokinase (KHK). Journal of Medicinal Chemistry. PMID 28853885 DOI: 10.1021/Acs.Jmedchem.7B00947  0.397
2015 Montgomery JI, Smith JF, Tomaras AP, Zaniewski R, McPherson CJ, McAllister LA, Hartman-Neumann S, Arcari JT, Lescoe M, Gutierrez J, Yuan Y, Limberakis C, Miller AA. Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors. The Journal of Antibiotics. 68: 361-7. PMID 25464974 DOI: 10.1038/Ja.2014.163  0.438
2012 Clinch K, Evans GB, Fröhlich RF, Gulab SA, Gutierrez JA, Mason JM, Schramm VL, Tyler PC, Woolhouse AD. Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. Bioorganic & Medicinal Chemistry. 20: 5181-7. PMID 22854195 DOI: 10.1016/j.bmc.2012.07.006  0.41
2010 Meyer ME, Gutierrez JA, Raushel FM, Richards NG. A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase. Biochemistry. 49: 9391-401. PMID 20853825 DOI: 10.1021/Bi1010688  0.619
2010 Longshaw AI, Adanitsch F, Gutierrez JA, Evans GB, Tyler PC, Schramm VL. Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase. Journal of Medicinal Chemistry. 53: 6730-46. PMID 20718423 DOI: 10.1021/Jm100898V  0.395
2006 Gutierrez JA, Pan YX, Koroniak L, Hiratake J, Kilberg MS, Richards NG. An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line. Chemistry & Biology. 13: 1339-47. PMID 17185229 DOI: 10.1016/J.Chembiol.2006.10.010  0.662
2005 Ciustea M, Gutierrez JA, Abbatiello SE, Eyler JR, Richards NG. Efficient expression, purification, and characterization of C-terminally tagged, recombinant human asparagine synthetase. Archives of Biochemistry and Biophysics. 440: 18-27. PMID 16023613 DOI: 10.1016/J.Abb.2005.05.023  0.639
2003 Koroniak L, Ciustea M, Gutierrez JA, Richards NG. Synthesis and characterization of an N-acylsulfonamide inhibitor of human asparagine synthetase. Organic Letters. 5: 2033-6. PMID 12790521 DOI: 10.1021/Ol034212N  0.491
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