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Justin L. Grobe, Ph.D. - Publications

Affiliations: 
2006 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Physiology Biology, Pharmacology
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83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Oliveira V, Riedl RA, Claflin KE, Marin Mathieu N, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, ... ... Grobe JL, et al. Melanocortin MC4R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Physiological Genomics. PMID 35476598 DOI: 10.1152/physiolgenomics.00015.2022  0.327
2020 Zanaty M, Seara FAC, Nakagawa P, Deng G, Mathieu NM, Balapattabi K, Karnik SS, Grobe JL, Sigmund CD. β-Arrestin-Biased Agonist Targeting the Brain ATR (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12015. PMID 33249862 DOI: 10.1161/HYPERTENSIONAHA.120.15793  0.305
2020 Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD. Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12014. PMID 32507043 DOI: 10.1161/Hypertensionaha.120.14972  0.409
2020 Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12015. PMID 32507042 DOI: 10.1161/Hypertensionaha.120.15137  0.325
2020 Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD. Failure to Vasodilate in Response to Salt Loading Blunts Renal Blood Flow and Causes Salt-Sensitive Hypertension. Cardiovascular Research. PMID 32428209 DOI: 10.1093/Cvr/Cvaa147  0.328
2020 Sapouckey SA, Morselli LL, Deng G, Patil C, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL. Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or Agouti-related peptide. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 32186897 DOI: 10.1152/Ajpregu.00297.2019  0.373
2020 Nakagawa P, Gomez J, Grobe JL, Sigmund CD. The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. Current Hypertension Reports. 22: 7. PMID 31925571 DOI: 10.1007/S11906-019-1011-2  0.349
2020 Patil CN, Oliveira V, Opichka M, Ritter ML, Reho JJ, Segar JL, Sigmund CD, Grobe JL. Abstract P239: Diet Modifies Cardiometabolic Effects Of DOCA-salt In C57BL/6J Mice Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.P239  0.33
2020 Scroggins SM, Gray G, Myers MC, Miller SN, Nakagawa P, Santillan DA, Grobe JL, Santillan MK. Abstract P137: Knock Out Of Regulatory G Protein Signaling 2 Specifically In CD4 T Cells Prevents Angiotensin II Induced Hypertension Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.P137  0.346
2020 Nakagawa P, Nair A, Gomez J, Wu J, Grobe JL, Sigmund CD. Susceptibility of Mice Lacking Renin‐b to Chronic Angiotensin II Infusion The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06804  0.348
2020 Balapattabi K, Patil CN, Deng G, Sigmund CD, Grobe JL. CREB and ERK Activation by Leptin and Angiotensin in the GT1‐7 Cell Model by Capillary Electrophoresis‐Based Western Blotting The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02546  0.303
2020 Hei MV, Patil CN, Sapouckey SA, Balapattabi K, Oliveira V, Deng G, Grobe JL. Assessing the Effects of Leptin and Angiotensin II Upon Expression of Agouti‐Related Peptide in the GT1‐7 Cell Model The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02256  0.315
2020 Patil CN, Oliveira V, Balapattabi K, Hei MV, Saravia F, Wackman K, Reho JJ, Kirby JR, Sigmund CD, Grobe JL. Common Laboratory Chow Diets Differentially Affect Energy Homeostasis and Modify Metabolic and Electrolyte Balance Effects of DOCA‐salt in Wildtype Mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02253  0.3
2019 Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, ... ... Grobe JL, et al. Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11914. PMID 31865781 DOI: 10.1161/Hypertensionaha.119.14056  0.343
2019 Guo DF, Lin Z, Wu Y, Searby C, Thedens DR, Richerson GB, Usachev YM, Grobe JL, Sheffield VC, Rahmouni K. The BBSome in POMC and AgRP Neurons is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors. Diabetes. PMID 31127052 DOI: 10.2337/Db18-1088  0.319
2019 Nair AR, Silva SD, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11913. PMID 31104564 DOI: 10.1161/Hypertensionaha.119.13101  0.362
2019 Nakagawa P, Nair A, Zhang SY, Lu K, Zanaty M, Gomez J, Grobe JL, Sigmund CD. Abstract 098: Susceptibility of Mice Lacking Renin-B to Chronic Angiotensin II Infusion Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.098  0.345
2018 Deng G, Grobe JL. The renin-angiotensin system in the arcuate nucleus controls resting metabolic rate. Current Opinion in Nephrology and Hypertension. PMID 30531199 DOI: 10.1097/Mnh.0000000000000477  0.327
2018 Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, ... ... Grobe JL, et al. Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. Jci Insight. 3. PMID 30282823 DOI: 10.1172/Jci.Insight.99403  0.38
2018 Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL. Regulators of G-Protein Signaling in Cardiovascular Function During Pregnancy. Physiological Genomics. PMID 29702036 DOI: 10.1152/Physiolgenomics.00037.2018  0.323
2018 Morselli LL, Claflin KE, Cui H, Grobe JL. Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin. Current Hypertension Reports. 20: 25. PMID 29556733 DOI: 10.1007/S11906-018-0824-8  0.3
2018 Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated Vasopressin in Pregnant Mice Induces T Helper Subset Alterations Consistent with Human Preeclampsia. Clinical Science (London, England : 1979). PMID 29371289 DOI: 10.1042/Cs20171059  0.322
2018 Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 29364700 DOI: 10.1152/Ajpregu.00435.2017  0.386
2018 Nair AR, Mukohda M, Agbor LN, Lu K, Wu J, Sandgren JA, Grobe JL, Sigmund CD. Abstract 133: Endothelial-Specific Interference With PPARγ Increases the Susceptibility to Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born from AVP-Infused Pregnancies Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.133  0.394
2018 Seara F, Nakagawa P, Gomez JA, Deng G, Sebag JA, Karnik SS, Grobe JL, Sigmund CD. Abstract 104: DOCA Induced Natriorexigenic and Hypertensive Effects are Blunted by Central Infusion of AT1 Receptor Biased Agonist TRV120027 Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.104  0.35
2017 Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential Mechanisms of Hypothalamic Renin-Angiotensin System Activation by Leptin and DOCA-salt for the Control of Resting Metabolism. Physiological Genomics. physiolgenomics.0008. PMID 28986397 DOI: 10.1152/Physiolgenomics.00087.2017  0.414
2017 Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA. MRAP2 regulates ghrelin receptor signaling and hunger sensing. Nature Communications. 8: 713. PMID 28959025 DOI: 10.1038/S41467-017-00747-6  0.31
2017 Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD. Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. Hypertension (Dallas, Tex. : 1979). PMID 28874461 DOI: 10.1161/Hypertensionaha.117.09923  0.354
2017 Grobe JL. Comprehensive Assessments of Energy Balance in Mice. Methods in Molecular Biology (Clifton, N.J.). 1614: 123-146. PMID 28500600 DOI: 10.1007/978-1-4939-7030-8_10  0.352
2017 Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD. Evidence for Intraventricular Secretion of Angiotensinogen and Angiotensin by the Subfornical Organ Using Transgenic Mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00511.2016. PMID 28490451 DOI: 10.1152/Ajpregu.00511.2016  0.409
2017 Claflin KE, Sandgren JA, Lambertz AM, Weidemann BJ, Littlejohn NK, Burnett CM, Pearson NA, Morgan DA, Gibson-Corley KN, Rahmouni K, Grobe JL. Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism. The Journal of Clinical Investigation. PMID 28263184 DOI: 10.1172/Jci88641  0.402
2016 Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD. Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension (Dallas, Tex. : 1979). PMID 27754863 DOI: 10.1161/Hypertensionaha.116.08242  0.413
2016 Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, ... ... Grobe JL, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Reports. PMID 27477281 DOI: 10.1016/J.Celrep.2016.07.003  0.4
2016 Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K. mTORC1 Signaling Contributes to Drinking but Not Blood Pressure Responses to Brain Angiotensin II. Endocrinology. en20161243. PMID 27254006 DOI: 10.1210/En.2016-1243  0.407
2016 Sandgren JA, Santillan MK, Grobe JL. Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions. Hypertension. 67: 1119-20. PMID 27113050 DOI: 10.1161/Hypertensionaha.116.07380  0.334
2016 Guo DF, Cui H, Zhang Q, Morgan DA, Thedens DR, Nishimura D, Grobe JL, Sheffield VC, Rahmouni K. The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. Plos Genetics. 12: e1005890. PMID 26926121 DOI: 10.1371/Journal.Pgen.1005890  0.306
2016 Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, et al. Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. Hypertension. PMID 26902490 DOI: 10.1161/Hypertensionaha.115.06433  0.327
2015 Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD. Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. PMID 26597823 DOI: 10.1161/Hypertensionaha.115.06391  0.339
2015 Littlejohn NK, Grobe JL. Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R1463-73. PMID 26491099 DOI: 10.1152/Ajpregu.00224.2015  0.347
2015 Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL. Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System. Scientific Reports. 5: 11123. PMID 26068176 DOI: 10.1038/Srep11123  0.345
2015 Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD. Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. Hypertension. 65: 1341-8. PMID 25895586 DOI: 10.1161/Hypertensionaha.115.05377  0.335
2015 Claflin KE, Grobe JL. Control of energy balance by the brain renin-angiotensin system. Current Hypertension Reports. 17: 38. PMID 25833461 DOI: 10.1007/S11906-015-0549-X  0.337
2015 Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: the missing link for preeclampsia? American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R1062-4. PMID 25810383 DOI: 10.1152/Ajpregu.00073.2015  0.305
2015 Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiological Reports. 3. PMID 25602015 DOI: 10.14814/Phy2.12257  0.354
2015 Coble JP, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R238-49. PMID 25519738 DOI: 10.1152/Ajpregu.00486.2014  0.401
2015 Santillan M, Santillan D, Scroggins S, Sandgren J, Pearson N, Gibson-Corley K, Grobe J. [33-OR]: Chronic vasopressin infusion throughout pregnancy phenocopies the physiologic, vascular, obstetric and immunologic phenotypes of human preeclampsia in mice Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 5: 16. DOI: 10.1016/J.Preghy.2014.10.037  0.341
2014 Shi P, Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK, Sumners C. Direct pro-inflammatory effects of prorenin on microglia. Plos One. 9: e92937. PMID 25302502 DOI: 10.1371/Journal.Pone.0092937  0.41
2014 Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sivitz WI. A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice. The Journal of Pharmacology and Experimental Therapeutics. 351: 699-708. PMID 25301169 DOI: 10.1124/Jpet.114.219329  0.31
2014 Grobe JL, Sigmund CD. Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants. Hypertension. 64: 1182-3. PMID 25225201 DOI: 10.1161/Hypertensionaha.114.04075  0.389
2014 Carrillo-Sepulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD. Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. Plos One. 9: e103786. PMID 25122005 DOI: 10.1371/Journal.Pone.0103786  0.401
2014 Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S. Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia. Cellular Signalling. 26: 2514-20. PMID 25093805 DOI: 10.1016/J.Cellsig.2014.07.030  0.404
2014 Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, Leslie KK, Hunter SK, Zamba GK, Gibson-Corley KN, Grobe JL. Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model. Hypertension. 64: 852-9. PMID 25001273 DOI: 10.1161/Hypertensionaha.114.03848  0.308
2014 Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD. Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R376-86. PMID 24965793 DOI: 10.1152/Ajpregu.00216.2014  0.408
2014 Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD. Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin. Hypertension. 64: 141-8. PMID 24777977 DOI: 10.1161/Hypertensionaha.114.03461  0.338
2014 Li W, Peng H, Mehaffey EP, Kimball CD, Grobe JL, van Gool JM, Sullivan MN, Earley S, Danser AH, Ichihara A, Feng Y. Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension. Hypertension. 63: 316-23. PMID 24246383 DOI: 10.1161/Hypertensionaha.113.02041  0.334
2014 Weidemann B, Littlejohn N, Cole R, Grobe J. The brain renin-angiotensin system suppresses digestive efficiency (1126.13) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.1126.13  0.341
2013 Littlejohn NK, Siel RB, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL. Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R818-28. PMID 23535460 DOI: 10.1152/Ajpregu.00082.2013  0.418
2013 Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD. Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. Hypertension. 61: 716-22. PMID 23266541 DOI: 10.1161/Hypertensionaha.111.00356  0.315
2013 Grobe JL, Rahmouni K, Liu X, Sigmund CD. Metabolic rate regulation by the renin-angiotensin system: brain vs. body. PflüGers Archiv : European Journal of Physiology. 465: 167-75. PMID 22491893 DOI: 10.1007/S00424-012-1096-9  0.337
2012 Grobe JL, Rahmouni K. The adipose/circulating renin-angiotensin system cross-talk enters a new dimension. Hypertension (Dallas, Tex. : 1979). 60: 1389-90. PMID 23108659 DOI: 10.1161/Hypertensionaha.112.200543  0.402
2012 Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD. Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. Cell Metabolism. 16: 462-72. PMID 23040068 DOI: 10.1016/J.Cmet.2012.08.011  0.347
2012 Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD. PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circulation Research. 111: 1446-58. PMID 22962432 DOI: 10.1161/Circresaha.112.271577  0.33
2012 Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL. A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. American Journal of Physiology. Heart and Circulatory Physiology. 303: H197-206. PMID 22610169 DOI: 10.1152/Ajpheart.00974.2011  0.391
2012 Grobe JL, Rahmouni K. Editorial focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice.". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 302: R242-3. PMID 22071163 DOI: 10.1152/Ajpregu.00608.2011  0.375
2011 Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 301: R1067-77. PMID 21753145 DOI: 10.1152/Ajpregu.00124.2011  0.403
2011 Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. Hypertension. 57: 600-7. PMID 21263123 DOI: 10.1161/Hypertensionaha.110.165829  0.409
2011 Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. Physiological Genomics. 43: 286-94. PMID 21189370 DOI: 10.1152/Physiolgenomics.00208.2010  0.39
2010 Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD. The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metabolism. 12: 431-42. PMID 21035755 DOI: 10.1016/J.Cmet.2010.09.011  0.386
2010 Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD. Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. Hypertension. 56: 981-7. PMID 20823378 DOI: 10.1161/Hypertensionaha.110.157354  0.36
2009 Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 54: 1240-7. PMID 19822797 DOI: 10.1161/Hypertensionaha.109.138677  0.347
2009 Shenoy V, Grobe JL, Qi Y, Ferreira AJ, Fraga-Silva RA, Collamat G, Bruce E, Katovich MJ. 17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats. Peptides. 30: 2309-15. PMID 19747516 DOI: 10.1016/J.Peptides.2009.09.005  0.584
2008 Katovich MJ, Grobe JL, Raizada MK. Angiotensin-(1-7) as an antihypertensive, antifibrotic target. Current Hypertension Reports. 10: 227-32. PMID 18765095 DOI: 10.1007/S11906-008-0043-9  0.601
2008 Grobe JL, Xu D, Sigmund CD. An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda, Md.). 23: 187-93. PMID 18697992 DOI: 10.1152/Physiol.00002.2008  0.303
2008 Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. Hypertension. 51: 712-8. PMID 18250366 DOI: 10.1161/Hypertensionaha.107.100693  0.55
2007 Grobe JL, Der Sarkissian S, Stewart JM, Meszaros JG, Raizada MK, Katovich MJ. ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts. Clinical Science (London, England : 1979). 113: 357-64. PMID 17600530 DOI: 10.1042/Cs20070160  0.571
2007 Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). American Journal of Physiology. Heart and Circulatory Physiology. 292: H736-42. PMID 17098828 DOI: 10.1152/Ajpheart.00937.2006  0.619
2007 Li H, Gao Y, Grobe JL, Raizada MK, Katovich MJ, Sumners C. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor. American Journal of Physiology. Heart and Circulatory Physiology. 292: H727-35. PMID 17085538 DOI: 10.1152/Ajpheart.00938.2006  0.575
2006 Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension. American Journal of Physiology. Heart and Circulatory Physiology. 290: H2417-23. PMID 16415071 DOI: 10.1152/Ajpheart.01170.2005  0.602
2006 Grobe JL, Katovich MJ. Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats. Regulatory Peptides. 133: 62-7. PMID 16219374 DOI: 10.1016/J.Regpep.2005.09.018  0.604
2005 Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Experimental Physiology. 90: 783-90. PMID 16049057 DOI: 10.1113/Expphysiol.2005.031096  0.621
2005 Katovich MJ, Grobe JL, Huentelman M, Raizada MK. Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. Experimental Physiology. 90: 299-305. PMID 15640278 DOI: 10.1113/Expphysiol.2004.028522  0.59
2005 Li H, Gao Y, Grobe J, Raizada M, Katovich M, Sumners C. 627. Adenoviral-Mediated Systemic Transduction of the Angiotensin II (Ang II) Type 2 Receptor (AT2R) Enhances the Hypotensive Action of Losartan Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.167  0.611
2004 Grobe J, Rowland N, Katovich M. Role of angiotensin II and the subfornical organ in the pharmacological actions of ethanol Alcohol and Alcoholism. 39: 410-417. PMID 15289207 DOI: 10.1093/Alcalc/Agh079  0.535
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