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Austen Milnerwood - Publications

Affiliations: 
2016- McGill University, Montreal, QC, Canada 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bu M, Follett J, Deng I, Tatarnikov I, Wall S, Guenther D, Maczis M, Wimsatt G, Milnerwood A, Moehle MS, Khoshbouei H, Farrer MJ. Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice. Npj Parkinson's Disease. 9: 167. PMID 38110354 DOI: 10.1038/s41531-023-00609-7  0.558
2021 Kadgien CA, Kamesh A, Milnerwood AJ. Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition. Molecular Brain. 14: 143. PMID 34530877 DOI: 10.1186/s13041-021-00848-w  0.372
2021 Kuhlmann N, Wagner Valladolid M, Quesada-Ramírez L, Farrer MJ, Milnerwood AJ. Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons. Frontiers in Cellular Neuroscience. 15: 569031. PMID 33679324 DOI: 10.3389/fncel.2021.569031  0.572
2020 Kuhlmann N, Milnerwood AJ. A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2. Frontiers in Molecular Neuroscience. 13: 153. PMID 32973447 DOI: 10.3389/fnmol.2020.00153  0.33
2020 MacIsaac S, Quevedo Melo T, Zhang Y, Volta M, Farrer MJ, Milnerwood AJ. Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous mutations and ameliorated by genetic knock-out. Brain Communications. 2: fcz052. PMID 32510053 DOI: 10.1093/braincomms/fcz052  0.474
2019 Follett J, Fox JD, Gustavsson EK, Kadgien C, Munsie LN, Cao LP, Tatarnikov I, Milnerwood AJ, Farrer MJ. DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of Sorting Nexin 1. Neuroscience Letters. PMID 31082451 DOI: 10.1016/J.Neulet.2019.04.043  0.47
2018 Cataldi S, Follett J, Fox JD, Tatarnikov I, Kadgien C, Gustavsson EK, Khinda J, Milnerwood AJ, Farrer MJ. Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice. Npj Parkinson's Disease. 4: 27. PMID 30155515 DOI: 10.1038/S41531-018-0063-3  0.763
2018 Kovalenko M, Milnerwood A, Giordano J, St Claire J, Guide JR, Stromberg M, Gillis T, Sapp E, DiFiglia M, MacDonald ME, Carroll JB, Lee JM, Tappan S, Raymond L, Wheeler VC. HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction. Journal of Huntington's Disease. 7: 17-33. PMID 29480209 DOI: 10.3233/Jhd-170282  0.616
2017 Volta M, Beccano-Kelly DA, Paschall SA, Cataldi S, MacIsaac SE, Kuhlmann N, Kadgien CA, Tatarnikov I, Fox J, Khinda J, Mitchell E, Bergeron S, Melrose H, Farrer MJ, Milnerwood AJ. Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice. Elife. 6. PMID 28930069 DOI: 10.7554/Elife.28377  0.77
2016 Trinh J, Gustavsson EK, Vilariño-Güell C, Bortnick S, Latourelle J, McKenzie MB, Tu CS, Nosova E, Khinda J, Milnerwood A, Lesage S, Brice A, Tazir M, Aasly JO, Parkkinen L, et al. DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study. The Lancet. Neurology. PMID 27692902 DOI: 10.1016/S1474-4422(16)30203-4  0.514
2016 Dallérac GM, Cummings DM, Hirst MC, Milnerwood AJ, Murphy KP. Changes in Dopamine Signalling Do Not Underlie Aberrant Hippocampal Plasticity in a Mouse Model of Huntington's Disease. Neuromolecular Medicine. PMID 26782175 DOI: 10.1007/S12017-016-8384-Z  0.819
2015 Volta M, Milnerwood AJ, Farrer MJ. Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease. The Lancet. Neurology. 14: 1054-64. PMID 26376970 DOI: 10.1016/S1474-4422(15)00186-6  0.544
2015 Volta M, Cataldi S, Beccano-Kelly D, Munsie L, Tatarnikov I, Chou P, Bergeron S, Mitchell E, Lim R, Khinda J, Lloret A, Bennett CF, Paradiso C, Morari M, Farrer MJ, ... Milnerwood AJ, et al. Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release. Parkinsonism & Related Disorders. 21: 1156-63. PMID 26282470 DOI: 10.1016/J.Parkreldis.2015.07.025  0.75
2015 Dallérac GM, Levasseur G, Vatsavayai SC, Milnerwood AJ, Cummings DM, Kraev I, Huetz C, Evans KA, Walters SW, Rezaie P, Cho Y, Hirst MC, Murphy KP. Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels. Neuro-Degenerative Diseases. 15: 93-108. PMID 25871323 DOI: 10.1159/000375126  0.783
2015 Munsie LN, Milnerwood AJ, Seibler P, Beccano-Kelly DA, Tatarnikov I, Khinda J, Volta M, Kadgien C, Cao LP, Tapia L, Klein C, Farrer MJ. Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N. Human Molecular Genetics. 24: 1691-703. PMID 25416282 DOI: 10.1093/Hmg/Ddu582  0.59
2015 Beccano-Kelly DA, Volta M, Munsie LN, Paschall SA, Tatarnikov I, Co K, Chou P, Cao LP, Bergeron S, Mitchell E, Han H, Melrose HL, Tapia L, Raymond LA, Farrer MJ, ... Milnerwood AJ, et al. LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory. Human Molecular Genetics. 24: 1336-49. PMID 25343991 DOI: 10.1093/Hmg/Ddu543  0.734
2014 Beccano-Kelly DA, Kuhlmann N, Tatarnikov I, Volta M, Munsie LN, Chou P, Cao LP, Han H, Tapia L, Farrer MJ, Milnerwood AJ. Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. Frontiers in Cellular Neuroscience. 8: 301. PMID 25309331 DOI: 10.3389/Fncel.2014.00301  0.571
2014 Walker MD, Volta M, Cataldi S, Dinelle K, Beccano-Kelly D, Munsie L, Kornelsen R, Mah C, Chou P, Co K, Khinda J, Mroczek M, Bergeron S, Yu K, Cao LP, ... ... Milnerwood AJ, et al. Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging. Journal of Parkinson's Disease. 4: 483-98. PMID 25000966 DOI: 10.3233/Jpd-140344  0.687
2014 Araki E, Tsuboi Y, Daechsel J, Milnerwood A, Vilarino-Guell C, Fujii N, Mishima T, Oka T, Hara H, Fukae J, Farrer MJ. A novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1201-4. PMID 24676999 DOI: 10.1002/Mds.25833  0.543
2014 Coquinco A, Kojic L, Wen W, Wang YT, Jeon NL, Milnerwood AJ, Cynader M. A microfluidic based in vitro model of synaptic competition. Molecular and Cellular Neurosciences. 60: 43-52. PMID 24662423 DOI: 10.1016/j.mcn.2014.03.001  0.302
2014 Vilariño-Güell C, Rajput A, Milnerwood AJ, Shah B, Szu-Tu C, Trinh J, Yu I, Encarnacion M, Munsie LN, Tapia L, Gustavsson EK, Chou P, Tatarnikov I, Evans DM, Pishotta FT, et al. DNAJC13 mutations in Parkinson disease. Human Molecular Genetics. 23: 1794-801. PMID 24218364 DOI: 10.1093/Hmg/Ddt570  0.495
2013 Milnerwood AJ, Parsons MP, Young FB, Singaraja RR, Franciosi S, Volta M, Bergeron S, Hayden MR, Raymond LA. Memory and synaptic deficits in Hip14/DHHC17 knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 20296-301. PMID 24277827 DOI: 10.1073/Pnas.1222384110  0.576
2012 Milnerwood AJ, Kaufman AM, Sepers MD, Gladding CM, Zhang L, Wang L, Fan J, Coquinco A, Qiao JY, Lee H, Wang YT, Cynader M, Raymond LA. Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice. Neurobiology of Disease. 48: 40-51. PMID 22668780 DOI: 10.1016/J.Nbd.2012.05.013  0.684
2012 Gladding CM, Sepers MD, Xu J, Zhang LY, Milnerwood AJ, Lombroso PJ, Raymond LA. Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model. Human Molecular Genetics. 21: 3739-52. PMID 22523092 DOI: 10.1093/hmg/dds154  0.603
2012 Kaufman AM, Milnerwood AJ, Sepers MD, Coquinco A, She K, Wang L, Lee H, Craig AM, Cynader M, Raymond LA. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3992-4003. PMID 22442066 DOI: 10.1523/JNEUROSCI.4129-11.2012  0.567
2012 Fan J, Gladding CM, Wang L, Zhang LY, Kaufman AM, Milnerwood AJ, Raymond LA. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiology of Disease. 45: 999-1009. PMID 22198502 DOI: 10.1016/J.Nbd.2011.12.019  0.621
2012 Petkau TL, Neal SJ, Milnerwood A, Mew A, Hill AM, Orban P, Gregg J, Lu G, Feldman HH, Mackenzie IR, Raymond LA, Leavitt BR. Synaptic dysfunction in progranulin-deficient mice. Neurobiology of Disease. 45: 711-22. PMID 22062772 DOI: 10.1016/J.Nbd.2011.10.016  0.612
2012 Murphy K, Dallerac G, Milnerwood A, Cummings D, Vatsavayai S, Stramek A, Evans K, Walters S, Hirst M. B24 Dysfunctional dopaminergic neurones and biphasic activity-dependent dopamine release in mouse models of Huntington's disease Journal of Neurology, Neurosurgery, and Psychiatry. 83. DOI: 10.1136/Jnnp-2012-303524.40  0.782
2012 Hirst M, Vatsavayai S, Dallerac G, Milnerwood A, Cummings D, Rezaie P, Evans K, Stramek A, Walters S, Murphy K. B05 CAG profiling in R6/1 89Q indicates early and progressive expansion in critical neuronal populations and expansion and changes in surrounding glial cell populations Journal of Neurology, Neurosurgery & Psychiatry. 83: A7.1-A7. DOI: 10.1136/Jnnp-2012-303524.21  0.758
2011 Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, et al. Translation initiator EIF4G1 mutations in familial Parkinson disease. American Journal of Human Genetics. 89: 398-406. PMID 21907011 DOI: 10.1016/J.Ajhg.2011.08.009  0.413
2011 Tapia L, Milnerwood A, Guo A, Mills F, Yoshida E, Vasuta C, Mackenzie IR, Raymond L, Cynader M, Jia W, Bamji SX. Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11126-32. PMID 21813674 DOI: 10.1523/Jneurosci.6244-10.2011  0.597
2011 Singaraja RR, Huang K, Sanders SS, Milnerwood AJ, Hines R, Lerch JP, Franciosi S, Drisdel RC, Vaid K, Young FB, Doty C, Wan J, Bissada N, Henkelman RM, Green WN, et al. Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Human Molecular Genetics. 20: 3899-909. PMID 21775500 DOI: 10.1093/Hmg/Ddr308  0.483
2011 Dallérac GM, Vatsavayai SC, Cummings DM, Milnerwood AJ, Peddie CJ, Evans KA, Walters SW, Rezaie P, Hirst MC, Murphy KP. Impaired long-term potentiation in the prefrontal cortex of Huntington's disease mouse models: rescue by D1 dopamine receptor activation. Neuro-Degenerative Diseases. 8: 230-9. PMID 21282937 DOI: 10.1159/000322540  0.805
2010 Milnerwood AJ, Raymond LA. Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease. Trends in Neurosciences. 33: 513-23. PMID 20850189 DOI: 10.1016/j.tins.2010.08.002  0.635
2010 Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, Ko RW, Vasuta OC, Graham RK, Hayden MR, Murphy TH, Raymond LA. Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice. Neuron. 65: 178-90. PMID 20152125 DOI: 10.1016/J.Neuron.2010.01.008  0.614
2010 Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, Ko RWY, Vasuta OC, Graham RK, Hayden MR, Murphy TH, Raymond LA. Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice (DOI:10.1016/j.neuron.2010.01.008) Neuron. 65: 436. DOI: 10.1016/j.neuron.2010.01.031  0.553
2010 Petkau T, Neal SJ, Milnerwood A, Orban PC, Feldman HH, Raymond L, Mackenzie IR, Leavitt BR. S1-02-03: Generation and characterization of a mouse model of progranulin deficiency Alzheimer's & Dementia. 6: S65-S65. DOI: 10.1016/J.Jalz.2010.05.190  0.506
2007 Milnerwood AJ, Raymond LA. Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load. The Journal of Physiology. 585: 817-31. PMID 17947312 DOI: 10.1113/jphysiol.2007.142448  0.676
2007 Cummings DM, Milnerwood AJ, Dallérac GM, Vatsavayai SC, Hirst MC, Murphy KP. Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease. Brain Research Bulletin. 72: 103-7. PMID 17352933 DOI: 10.1016/J.Brainresbull.2006.10.016  0.815
2007 Vatsavayai SC, Dallérac GM, Milnerwood AJ, Cummings DM, Rezaie P, Murphy KP, Hirst MC. Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset. Brain Research Bulletin. 72: 98-102. PMID 17352932 DOI: 10.1016/J.Brainresbull.2006.10.015  0.774
2006 Cummings DM, Milnerwood AJ, Dallérac GM, Waights V, Brown JY, Vatsavayai SC, Hirst MC, Murphy KP. Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease. Human Molecular Genetics. 15: 2856-68. PMID 16905556 DOI: 10.1093/Hmg/Ddl224  0.807
2006 Milnerwood AJ, Cummings DM, Dallérac GM, Brown JY, Vatsavayai SC, Hirst MC, Rezaie P, Murphy KP. Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease. Human Molecular Genetics. 15: 1690-703. PMID 16600988 DOI: 10.1093/Hmg/Ddl092  0.809
2006 Milnerwood AJ, Raymond LA. Synaptic abnormalities associated with huntington's disease Molecular Mechanisms of Synaptogenesis. 457-471. DOI: 10.1007/978-0-387-32562-0_32  0.55
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