Chris Bakal - Publications

Institute of Cancer Research, London, UK 
cell morphogenesis, systems biology, mechanotransduction, cell imaging

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Varotsos Vrynas A, Perea Paizal J, Bakal C, Au SH. Arresting metastasis within the microcirculation. Clinical & Experimental Metastasis. PMID 34241735 DOI: 10.1007/s10585-021-10109-8  1
2021 Lightley J, Görlitz F, Kumar S, Kalita R, Kolbeinsson A, Garcia E, Alexandrov Y, Bousgouni V, Wysoczanski R, Barnes P, Donnelly L, Bakal C, Dunsby C, Neil MAA, Flaxman S, et al. Robust optical autofocus system utilizing neural networks trained for extended range and time-course and automated multiwell plate imaging including single molecule localization microscopy. Journal of Microscopy. PMID 34089183 DOI: 10.1111/jmi.13020  1
2020 Sparks H, Dent L, Bakal C, Behrens A, Salbreux G, Dunsby C. Dual-view oblique plane microscopy (dOPM). Biomedical Optics Express. 11: 7204-7220. PMID 33408991 DOI: 10.1364/BOE.409781  0.01
2020 Zhong Q, Roumeliotis TI, Kozik Z, Cepeda-Molero M, Fernández LÁ, Shenoy AR, Bakal C, Frankel G, Choudhary JS. Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells. Plos Biology. 18: e3000986. PMID 33378358 DOI: 10.1371/journal.pbio.3000986  0.01
2020 Perea Paizal J, Au SH, Bakal C. Squeezing through the microcirculation: survival adaptations of circulating tumour cells to seed metastasis. British Journal of Cancer. PMID 33257836 DOI: 10.1038/s41416-020-01176-x  1
2020 Hégarat N, Crncec A, Suarez Peredo Rodriguez MF, Echegaray Iturra F, Gu Y, Busby O, Lang PF, Barr AR, Bakal C, Kanemaki MT, Lamond AI, Novak B, Ly T, Hochegger H. Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B. The Embo Journal. e104419. PMID 32350921 DOI: 10.15252/Embj.2020104419  1
2020 Stojic L, Lun ATL, Mascalchi P, Ernst C, Redmond AM, Mangei J, Barr AR, Bousgouni V, Bakal C, Marioni JC, Odom DT, Gergely F. A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nature Communications. 11: 1851. PMID 32296040 DOI: 10.1038/S41467-020-14978-7  1
2020 Müller PM, Rademacher J, Bagshaw RD, Wortmann C, Barth C, van Unen J, Alp KM, Giudice G, Eccles RL, Heinrich LE, Pascual-Vargas P, Sanchez-Castro M, Brandenburg L, Mbamalu G, Tucholska M, ... ... Bakal C, et al. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Nature Cell Biology. PMID 32203420 DOI: 10.1038/S41556-020-0488-X  1
2019 Bakal C, Sero J. The forces of cancer. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 374: 20190103. PMID 31431173 DOI: 10.1098/Rstb.2019.0103  1
2019 Rashid M, van der Horst M, Mentzel T, Butera F, Ferreira I, Pance A, Rütten A, Luzar B, Marusic Z, de Saint Aubain N, Ko JS, Billings SD, Chen S, Abi Daoud M, Hewinson J, ... ... Bakal C, et al. ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma. Nature Communications. 10: 2213. PMID 31101826 DOI: 10.1038/S41467-019-09979-0  1
2019 Peñalosa-Ruiz G, Bousgouni V, Gerlach JP, Waarlo S, van de Ven JV, Veenstra TE, Silva JCR, van Heeringen SJ, Bakal C, Mulder KW, Veenstra GJC. WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming. Stem Cell Reports. PMID 30880078 DOI: 10.1016/J.Stemcr.2019.02.006  1
2019 Hansel CS, Crowder SW, Cooper S, Gopal S, João Pardelha da Cruz M, de Oliveira Martins L, Keller D, Rothery S, Becce M, Cass AEG, Bakal C, Chiappini C, Stevens MM. Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery. Acs Nano. PMID 30829469 DOI: 10.1021/Acsnano.8B06998  1
2018 Spill F, Bakal C, Mak M. Mechanical and Systems Biology of Cancer. Computational and Structural Biotechnology Journal. 16: 237-245. PMID 30105089 DOI: 10.1016/J.Csbj.2018.07.002  0.01
2018 Stojic L, Lun ATL, Mangei J, Mascalchi P, Quarantotti V, Barr AR, Bakal C, Marioni JC, Gergely F, Odom DT. Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis. Nucleic Acids Research. PMID 29860520 DOI: 10.1093/Nar/Gky437  1
2018 Sanchez-Alvarez M, Del Pozo MA, Bakal C. Publisher Correction: AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts. Scientific Reports. 8: 6476. PMID 29674750 DOI: 10.1038/S41598-018-24796-Z  1
2018 Heldt FS, Barr AR, Cooper S, Bakal C, Novák B. A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463760 DOI: 10.1073/Pnas.1715345115  1
2018 Sanchez-Alvarez M, Bakal C. PERK links the clock and protein stress in cancer. Nature Cell Biology. 20: 4-5. PMID 29269949 DOI: 10.1038/S41556-017-0019-6  1
2017 Sanchez-Alvarez M, Del Pozo MA, Bakal C. AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts. Scientific Reports. 7: 16497. PMID 29184100 DOI: 10.1038/S41598-017-16662-1  1
2017 Cooper S, Barr AR, Glen R, Bakal C. NucliTrack: An integrated nuclei tracking application. Bioinformatics (Oxford, England). PMID 28637183 DOI: 10.1093/Bioinformatics/Btx404  1
2017 Turner NC, Asghar U, Barr AR, Cutts R, Beaney M, Babina IS, Sampath D, Giltnane J, Lacap JA, Crocker L, Young A, Pearson A, Herrera-Abreu MT, Bakal C. Single-cell dynamics determines response to CDK4/6 inhibition in triple negative breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28606920 DOI: 10.1158/1078-0432.Ccr-17-0369  1
2017 Barr AR, Cooper S, Heldt FS, Butera F, Stoy H, Mansfeld J, Novák B, Bakal C. DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nature Communications. 8: 14728. PMID 28317845 DOI: 10.1038/Ncomms14728  1
2017 Pascual-Vargas P, Cooper S, Sero J, Bousgouni V, Arias-Garcia M, Bakal C. RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer. Scientific Data. 4: 170018. PMID 28248929 DOI: 10.1038/Sdata.2017.18  1
2017 Cooper S, Bakal C. Accelerating Live Single-Cell Signalling Studies. Trends in Biotechnology. PMID 28161141 DOI: 10.1016/J.Tibtech.2017.01.002  1
2017 Sero JE, Bakal C. Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion. Cell Systems. PMID 28065575 DOI: 10.1016/J.Cels.2016.11.015  1
2017 Sailem HZ, Bakal C. Identification of clinically predictive metagenes that encode components of a network coupling cell shape to transcription by image-omics. Genome Research. 27: 196-207. PMID 27864353 DOI: 10.1101/Gr.202028.115  1
2017 Asghar U, Barr A, Cuts R, Beaney M, Babina I, Sampath D, Lacap J, Crocker L, Young A, Nerukar A, Pearson A, Herrera-Abreu M, Bakal C, Turner N. Abstract P5-04-01: Cell cycle dynamics at single cell level dictates response to CDK4/6 inhibition Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P5-04-01  1
2017 Asghar U, Barr A, Cutts R, Beaney M, Sampath D, Giltnane J, Lacap JA, Herrera-Abreu M, Bakal C, Turner N. 44PUnravelling mechanisms of resistance to CDK4/6 inhibitors using triple negative breast cancer (TNBC) Annals of Oncology. 28. DOI: 10.1093/Annonc/Mdx145  1
2016 Mardakheh FK, Sailem HZ, Kümper S, Tape CJ, McCully RR, Paul A, Anjomani-Virmouni S, Jørgensen C, Poulogiannis G, Marshall CJ, Bakal C. Proteomics profiling of interactome dynamics by colocalisation analysis (COLA). Molecular Biosystems. PMID 27824369 DOI: 10.1039/C6Mb00701E  1
2016 Barr AR, Heldt FS, Zhang T, Bakal C, Novák B. A Dynamical Framework for the All-or-None G1/S Transition. Cell Systems. 2: 27-37. PMID 27136687 DOI: 10.1016/J.Cels.2016.01.001  1
2016 Sailem HZ, Cooper S, Bakal C. Visualizing quantitative microscopy data: History and challenges. Critical Reviews in Biochemistry and Molecular Biology. 1-6. PMID 26906253 DOI: 10.3109/10409238.2016.1146222  1
2016 Natrajan R, Sailem H, Mardakheh FK, Arias Garcia M, Tape CJ, Dowsett M, Bakal C, Yuan Y. Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis. Plos Medicine. 13: e1001961. PMID 26881778 DOI: 10.1371/Journal.Pmed.1001961  1
2016 Barr A, Heldt FS, Cooper S, Novak B, Bakal C. A single cell approach to understanding cell cycle entry in cancer European Journal of Cancer. 61. DOI: 10.1016/S0959-8049(16)61609-X  1
2015 Sanchez-Alvarez M, Zhang Q, Finger F, Wakelam MJ, Bakal C. Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis. Open Biology. 5: 150093. PMID 26333836 DOI: 10.1098/Rsob.150093  1
2015 Cooper S, Sadok A, Bousgouni V, Bakal C. Apolar and polar transitions drive the conversion between amoeboid and mesenchymal shapes in melanoma cells. Molecular Biology of the Cell. PMID 26310441 DOI: 10.1091/Mbc.E15-06-0382  1
2015 Barr AR, Bakal C. Erratum: A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly. Scientific Reports. 5: 12384. PMID 26230530 DOI: 10.1038/srep12384  1
2015 Sero JE, Sailem HZ, Ardy RC, Almuttaqi H, Zhang T, Bakal C. Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells. Molecular Systems Biology. 11: 790. PMID 26148352 DOI: 10.15252/Msb.20145644  1
2015 Barr AR, Bakal C. A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly. Scientific Reports. 5: 10564. PMID 26037491 DOI: 10.1038/Srep10564  1
2015 Sero JE, Sailem HZ, Ardy RC, Almuttaqi H, Zhang T, Bakal C. Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells. Molecular Systems Biology. 11: 790. PMID 25735303 DOI: 10.15252/msb.20145644  1
2015 Sailem HZ, Sero JE, Bakal C. Visualizing cellular imaging data using PhenoPlot. Nature Communications. 6: 5825. PMID 25569359 DOI: 10.1038/Ncomms6825  1
2014 Yin Z, Sailem H, Sero J, Ardy R, Wong ST, Bakal C. How cells explore shape space: a quantitative statistical perspective of cellular morphogenesis. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 1195-203. PMID 25220035 DOI: 10.1002/Bies.201400011  1
2014 Sanchez-Alvarez M, Finger F, Arias-Garcia Mdel M, Bousgouni V, Pascual-Vargas P, Bakal C. Signaling networks converge on TORC1-SREBP activity to promote endoplasmic reticulum homeostasis. Plos One. 9: e101164. PMID 25007267 DOI: 10.1371/Journal.Pone.0101164  1
2014 Sailem H, Bousgouni V, Cooper S, Bakal C. Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity. Open Biology. 4: 130132. PMID 24451547 DOI: 10.1098/Rsob.130132  1
2013 Bakal C. Chris Bakal: Look and learn. Interviewed by Caitlin Sedwick. The Journal of Cell Biology. 203: 378-9. PMID 24217614 DOI: 10.1083/jcb.2033pi  0.01
2013 Evans L, Sailem H, Vargas PP, Bakal C. Inferring signalling networks from images. Journal of Microscopy. 252: 1-7. PMID 23841886 DOI: 10.1111/Jmi.12062  1
2013 Yin Z, Sadok A, Sailem H, McCarthy A, Xia X, Li F, Garcia MA, Evans L, Barr AR, Perrimon N, Marshall CJ, Wong ST, Bakal C. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nature Cell Biology. 15: 860-71. PMID 23748611 DOI: 10.1038/Ncb2764  1
2012 Garcia MA, Alvarez MS, Sailem H, Bousgouni V, Sero J, Bakal C. Differential RNAi screening provides insights into the rewiring of signalling networks during oxidative stress. Molecular Biosystems. 8: 2605-13. PMID 22790786 DOI: 10.1039/C2Mb25092F  1
2012 Barr AR, Bakal C. A direct look at RNAi screens. Molecular Systems Biology. 8: 580. PMID 22531120 DOI: 10.1038/Msb.2012.14  1
2012 Bakal C. Dynamic systems. Genome Biology. 13: 312. PMID 22289510 DOI: 10.1186/gb-2012-13-1-312  0.01
2011 Sero JE, Thodeti CK, Mammoto A, Bakal C, Thomas S, Ingber DE. Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. Plos One. 6: e28303. PMID 22194823 DOI: 10.1371/Journal.Pone.0028303  1
2011 Bakal C. Drosophila RNAi screening in a postgenomic world. Briefings in Functional Genomics. 10: 197-205. PMID 21752787 DOI: 10.1093/Bfgp/Elr015  0.01
2010 Bakal C, Perrimon N. Realizing the promise of RNAi high throughput screening. Developmental Cell. 18: 506-7. PMID 20412765 DOI: 10.1016/J.Devcel.2010.04.005  1
2010 Mohr S, Bakal C, Perrimon N. Genomic screening with RNAi: results and challenges. Annual Review of Biochemistry. 79: 37-64. PMID 20367032 DOI: 10.1146/Annurev-Biochem-060408-092949  1
2010 Nir O, Bakal C, Perrimon N, Berger B. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Genome Research. 20: 372-80. PMID 20144944 DOI: 10.1101/Gr.100248.109  1
2009 Griffin R, Sustar A, Bonvin M, Binari R, del Valle Rodriguez A, Hohl AM, Bateman JR, Villalta C, Heffern E, Grunwald D, Bakal C, Desplan C, Schubiger G, Wu CT, Perrimon N. The twin spot generator for differential Drosophila lineage analysis. Nature Methods. 6: 600-2. PMID 19633664 DOI: 10.1038/Nmeth.1349  1
2009 Kaplow IM, Singh R, Friedman A, Bakal C, Perrimon N, Berger B. RNAiCut: automated detection of significant genes from functional genomic screens. Nature Methods. 6: 476-7. PMID 19564846 DOI: 10.1038/Nmeth0709-476  1
2008 Bakal C, Linding R, Llense F, Heffern E, Martin-Blanco E, Pawson T, Perrimon N. Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (New York, N.Y.). 322: 453-6. PMID 18927396 DOI: 10.1126/Science.1158739  1
2008 Yin Z, Zhou X, Bakal C, Li F, Sun Y, Perrimon N, Wong ST. Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. Bmc Bioinformatics. 9: 264. PMID 18534020 DOI: 10.1186/1471-2105-9-264  1
2008 Baym M, Bakal C, Perrimon N, Berger B. High-resolution modeling of cellular signaling networks Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 4955: 257-271. DOI: 10.1007/978-3-540-78839-3_22  1
2007 Bakal C, Aach J, Church G, Perrimon N. Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (New York, N.Y.). 316: 1753-6. PMID 17588932 DOI: 10.1126/Science.1140324  1
2007 Yin Z, Zhou X, Bakal C, Li F, Sun Y, Perrimon N, Wong STC. Online phenotype discovery in high-content RNAi screens using gap statistics Aip Conference Proceedings. 952: 86-95. DOI: 10.1063/1.2816647  1
2005 Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S, Mak TW. Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Cancer Research. 65: 6685-91. PMID 16061649 DOI: 10.1158/0008-5472.Can-04-4223  1
2005 Bakal CJ, Finan D, LaRose J, Wells CD, Gish G, Kulkarni S, DeSepulveda P, Wilde A, Rottapel R. The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 9529-34. PMID 15976019 DOI: 10.1073/Pnas.0504190102  1
2004 Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. The Journal of Experimental Medicine. 200: 1167-77. PMID 15520247 DOI: 10.1084/Jem.20032246  1
2004 Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zúñiga-Pflücker JC, Mak TW. Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. The Journal of Experimental Medicine. 199: 399-410. PMID 14757745 DOI: 10.1084/Jem.20032092  1
2003 Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, et al. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18: 763-75. PMID 12818158 DOI: 10.1016/S1074-7613(03)00148-1  1
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