David Leib, Ph.D. - Publications

Affiliations: 
Microbiology and Immunology Geisel School of Medicine at Dartmouth, Hanover, NH, United States 

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME. Effector functions are required for broad and potent protection of neonatal mice with antibodies targeting HSV glycoprotein D. Cell Reports. Medicine. 101417. PMID 38350452 DOI: 10.1016/j.xcrm.2024.101417  0.315
2023 Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME. Antibody effector functions are required for broad and potent protection of neonates from herpes simplex virus infection. Biorxiv : the Preprint Server For Biology. PMID 37693377 DOI: 10.1101/2023.08.29.555423  0.344
2022 Backes IM, Byrd BK, Slein MD, Patel CD, Taylor SA, Garland CR, MacDonald SW, Balazs AB, Davis SC, Ackerman ME, Leib DA. Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity. The Journal of Experimental Medicine. 219. PMID 36156707 DOI: 10.1084/jem.20220110  0.333
2022 Backes IM, Leib DA, Ackerman ME. Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections. Frontiers in Immunology. 13: 959603. PMID 36016956 DOI: 10.3389/fimmu.2022.959603  0.336
2022 Hayes CK, Villota CK, McEnany FB, Cerón S, Awasthi S, Szpara ML, Friedman HM, Leib DA, Longnecker R, Weitzman MD, Akhtar LN. Herpes Simplex Virus (HSV)-2 Variation Contributes to Neurovirulence During Neonatal Infection. The Journal of Infectious Diseases. PMID 35451492 DOI: 10.1093/infdis/jiac151  0.347
2020 Manivanh R, Mehrbach J, Charron AJ, Grassetti A, Cerón S, Taylor SA, Cabrera JR, Gerber S, Leib DA. Herpes Simplex Virus 1 ICP34.5 Alters Mitochondrial Dynamics in Neurons. Journal of Virology. PMID 32376626 DOI: 10.1128/Jvi.01784-19  0.375
2019 Cabrera JR, Manivanh R, North BJ, Leib DA. The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection. Mbio. 10. PMID 30837340 DOI: 10.1128/mBio.02567-18  0.398
2019 Charron AJ, Ward SL, North BJ, Ceron S, Leib DA. The US11 gene of Herpes Simplex Virus 1 promotes neuroinvasion and periocular replication following corneal infection. Journal of Virology. PMID 30760571 DOI: 10.1128/JVI.02246-18  0.482
2019 Cerón S, North BJ, Taylor SA, Leib DA. The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease. Virology. 529: 23-28. PMID 30648635 DOI: 10.1016/j.virol.2019.01.006  0.466
2018 Cabrera JR, Charron AJ, Leib DA. Neuronal subtype determines HSV-1 Latency-Associated-Transcript (LAT) promoter activity during latency. Journal of Virology. PMID 29643250 DOI: 10.1128/JVI.00430-18  0.312
2017 Manivanh R, Mehrbach J, Knipe DM, Leib DA. The Role of Herpes Simplex Virus Type 1 γ34.5 in the Regulation of IRF3 Signaling. Journal of Virology. PMID 28904192 DOI: 10.1128/Jvi.01156-17  0.487
2016 Parker ZM, Pasieka TJ, Parker GA, Leib DA. Immune and non-immune compartment-specific IFN responses are critical determinants of HSV-induced generalized infections and acute liver failure. Journal of Virology. PMID 27681121 DOI: 10.1128/JVI.01473-16  0.334
2016 Katzenell S, Leib DA. Herpes simplex virus and interferon signaling induce novel autophagic clusters in sensory neurons. Journal of Virology. PMID 26912623 DOI: 10.1128/JVI.02908-15  0.345
2015 Parker ZM, Murphy AA, Leib DA. Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1. Journal of Virology. 89: 11080-91. PMID 26311879 DOI: 10.1128/JVI.00954-15  0.424
2015 Rosato PC, Leib DA. Neurons versus herpes simplex virus: the innate immune interactions that contribute to a host-pathogen standoff. Future Virology. 10: 699-714. PMID 26213562 DOI: 10.2217/fvl.15.45  0.365
2015 Rosato PC, Leib DA. Neuronal Interferon Signaling Is Required for Protection against Herpes Simplex Virus Replication and Pathogenesis. Plos Pathogens. 11: e1005028. PMID 26153886 DOI: 10.1371/journal.ppat.1005028  0.344
2014 Rosato PC, Leib DA. Intrinsic innate immunity fails to control herpes simplex virus and vesicular stomatitis virus replication in sensory neurons and fibroblasts. Journal of Virology. 88: 9991-10001. PMID 24942587 DOI: 10.1128/JVI.01462-14  0.33
2014 Pan D, Flores O, Umbach JL, Pesola JM, Bentley P, Rosato PC, Leib DA, Cullen BR, Coen DM. A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency. Cell Host & Microbe. 15: 446-56. PMID 24721573 DOI: 10.1016/J.Chom.2014.03.004  0.376
2014 Katzenell S, Chen Y, Parker ZM, Leib DA. The differential interferon responses of two strains of Stat1-deficient mice do not alter susceptibility to HSV-1 and VSV in vivo. Virology. 450: 350-4. PMID 24503098 DOI: 10.1016/j.virol.2013.12.015  0.364
2013 Murphy AA, Rosato PC, Parker ZM, Khalenkov A, Leib DA. Synergistic control of herpes simplex virus pathogenesis by IRF-3, and IRF-7 revealed through non-invasive bioluminescence imaging. Virology. 444: 71-9. PMID 23777662 DOI: 10.1016/j.virol.2013.05.034  0.309
2013 Radtke K, English L, Rondeau C, Leib D, Lippé R, Desjardins M. Inhibition of the host translation shutoff response by herpes simplex virus 1 triggers nuclear envelope-derived autophagy. Journal of Virology. 87: 3990-7. PMID 23365427 DOI: 10.1128/JVI.02974-12  0.501
2012 Leib DA. Herpes simplex virus encephalitis: toll-free access to the brain. Cell Host & Microbe. 12: 731-2. PMID 23245315 DOI: 10.1016/j.chom.2012.11.005  0.336
2012 Gobeil PA, Leib DA. Herpes simplex virus γ34.5 interferes with autophagosome maturation and antigen presentation in dendritic cells. Mbio. 3: e00267-12. PMID 23073763 DOI: 10.1128/mBio.00267-12  0.429
2012 Yordy B, Iijima N, Huttner A, Leib D, Iwasaki A. A neuron-specific role for autophagy in antiviral defense against herpes simplex virus. Cell Host & Microbe. 12: 334-45. PMID 22980330 DOI: 10.1016/J.Chom.2012.07.013  0.406
2012 Pasieka TJ, Menachery VD, Rosato PC, Leib DA. Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff. Journal of Virology. 86: 7692-5. PMID 22553331 DOI: 10.1128/Jvi.00761-12  0.408
2012 Morris JE, Zobell S, Yin XT, Zakeri H, Summers BC, Leib DA, Stuart PM. Mice with mutations in Fas and Fas ligand demonstrate increased herpetic stromal keratitis following corneal infection with HSV-1. Journal of Immunology (Baltimore, Md. : 1950). 188: 793-9. PMID 22156346 DOI: 10.4049/jimmunol.1102251  0.33
2011 Pasieka TJ, Cilloniz C, Carter VS, Rosato P, Katze MG, Leib DA. Functional genomics reveals an essential and specific role for Stat1 in protection of the central nervous system following herpes simplex virus corneal infection. Journal of Virology. 85: 12972-81. PMID 21994441 DOI: 10.1128/JVI.06032-11  0.432
2011 Pasieka TJ, Collins L, O'Connor MA, Chen Y, Parker ZM, Berwin BL, Piwnica-Worms DR, Leib DA. Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in αßγ interferon receptor-deficient mice. Plos One. 6: e24018. PMID 21915277 DOI: 10.1371/Journal.Pone.0024018  0.365
2010 Menachery VD, Pasieka TJ, Leib DA. Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection. Journal of Virology. 84: 9685-94. PMID 20660188 DOI: 10.1128/Jvi.00706-10  0.421
2009 Menachery VD, Leib DA. Control of herpes simplex virus replication is mediated through an interferon regulatory factor 3-dependent pathway. Journal of Virology. 83: 12399-406. PMID 19759149 DOI: 10.1128/Jvi.00888-09  0.432
2009 Leib DA, Alexander DE, Cox D, Yin J, Ferguson TA. Interaction of ICP34.5 with Beclin 1 modulates herpes simplex virus type 1 pathogenesis through control of CD4+ T-cell responses. Journal of Virology. 83: 12164-71. PMID 19759141 DOI: 10.1128/JVI.01676-09  0.416
2009 English L, Chemali M, Duron J, Rondeau C, Laplante A, Gingras D, Alexander D, Leib D, Norbury C, Lippé R, Desjardins M. Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nature Immunology. 10: 480-7. PMID 19305394 DOI: 10.1038/Ni.1720  0.346
2009 Pasieka TJ, Cilloniz C, Lu B, Teal TH, Proll SC, Katze MG, Leib DA. Host responses to wild-type and attenuated herpes simplex virus infection in the absence of Stat1. Journal of Virology. 83: 2075-87. PMID 19109391 DOI: 10.1128/JVI.02007-08  0.453
2008 Keadle TL, Alexander DE, Leib DA, Stuart PM. Interferon gamma is not required for recurrent herpetic stromal keratitis. Virology. 380: 46-51. PMID 18755490 DOI: 10.1016/j.virol.2008.07.018  0.344
2008 Pasieka TJ, Lu B, Leib DA. Enhanced pathogenesis of an attenuated herpes simplex virus for mice lacking Stat1. Journal of Virology. 82: 6052-5. PMID 18400863 DOI: 10.1128/JVI.00297-08  0.432
2008 Pasieka TJ, Lu B, Crosby SD, Wylie KM, Morrison LA, Alexander DE, Menachery VD, Leib DA. Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state. Journal of Virology. 82: 5527-35. PMID 18367525 DOI: 10.1128/Jvi.02047-07  0.46
2008 Alexander DE, Leib DA. Xenophagy in herpes simplex virus replication and pathogenesis. Autophagy. 4: 101-3. PMID 18000391  0.425
2007 Orvedahl A, Alexander D, Tallóczy Z, Sun Q, Wei Y, Zhang W, Burns D, Leib DA, Levine B. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host & Microbe. 1: 23-35. PMID 18005679 DOI: 10.1016/J.Chom.2006.12.001  0.41
2007 Alexander DE, Ward SL, Mizushima N, Levine B, Leib DA. Analysis of the role of autophagy in replication of herpes simplex virus in cell culture. Journal of Virology. 81: 12128-34. PMID 17855538 DOI: 10.1128/JVI.01356-07  0.476
2007 Margolis TP, Elfman FL, Leib D, Pakpour N, Apakupakul K, Imai Y, Voytek C. Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory ganglia. Journal of Virology. 81: 11069-74. PMID 17686862 DOI: 10.1128/JVI.00243-07  0.468
2007 Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, García-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW. IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proceedings of the National Academy of Sciences of the United States of America. 104: 1371-6. PMID 17227866 DOI: 10.1073/Pnas.0607038104  0.473
2006 Pasieka TJ, Baas T, Carter VS, Proll SC, Katze MG, Leib DA. Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response. Journal of Virology. 80: 7600-12. PMID 16840339 DOI: 10.1128/Jvi.00333-06  0.5
2006 Luker KE, Schultz T, Romine J, Leib DA, Luker GD. Transgenic reporter mouse for bioluminescence imaging of herpes simplex virus 1 infection in living mice. Virology. 347: 286-95. PMID 16430938 DOI: 10.1016/j.virol.2005.12.016  0.441
2005 Luker GD, Leib DA. Luciferase real-time bioluminescence imaging for the study of viral pathogenesis. Methods in Molecular Biology (Clifton, N.J.). 292: 285-96. PMID 15507716  0.418
2004 Strand SS, Leib DA. Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesis. Journal of Virology. 78: 13562-72. PMID 15564467 DOI: 10.1128/JVI.78.24.13562-13572.2004  0.421
2004 Strand SS, Vanheyningen TK, Leib DA. The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons. Journal of Virology. 78: 8400-3. PMID 15254212 DOI: 10.1128/JVI.78.15.8400-8403.2004  0.365
2004 Krug A, Luker GD, Barchet W, Leib DA, Akira S, Colonna M. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood. 103: 1433-7. PMID 14563635 DOI: 10.1182/blood-2003-08-2674  0.343
2003 Luker GD, Prior JL, Song J, Pica CM, Leib DA. Bioluminescence imaging reveals systemic dissemination of herpes simplex virus type 1 in the absence of interferon receptors. Journal of Virology. 77: 11082-93. PMID 14512556 DOI: 10.1128/JVI.77.20.11082-11093.2003  0.323
2003 Ward SL, Scheuner D, Poppers J, Kaufman RJ, Mohr I, Leib DA. In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation. Journal of Virology. 77: 4626-34. PMID 12663769 DOI: 10.1128/Jvi.77.8.4626-4634.2003  0.453
2003 Smith TJ, Silverman RH, Leib DA. RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection. The Journal of General Virology. 84: 925-8. PMID 12655093 DOI: 10.1099/vir.0.18695-0  0.413
2002 Luker GD, Bardill JP, Prior JL, Pica CM, Piwnica-Worms D, Leib DA. Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. Journal of Virology. 76: 12149-61. PMID 12414955 DOI: 10.1128/Jvi.76.23.12149-12161.2002  0.459
2002 Summers BC, Leib DA. Herpes simplex virus type 1 origins of DNA replication play no role in the regulation of flanking promoters. Journal of Virology. 76: 7020-9. PMID 12072502 DOI: 10.1128/JVI.76.14.7020-7029.2002  0.372
2002 Smith TJ, Morrison LA, Leib DA. Pathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants. Journal of Virology. 76: 2054-61. PMID 11836383 DOI: 10.1128/Jvi.76.5.2054-2061.2002  0.446
2002 Davido DJ, Leib DA, Schaffer PA. The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0. Journal of Virology. 76: 1077-88. PMID 11773384 DOI: 10.1128/Jvi.76.3.1077-1088.2002  0.328
2002 Tallóczy Z, Jiang W, Virgin HW, Leib DA, Scheuner D, Kaufman RJ, Eskelinen EL, Levine B. Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 99: 190-5. PMID 11756670 DOI: 10.1073/Pnas.012485299  0.416
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