| Year |
Citation |
Score |
| 2022 |
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, ... ... Pan YX, et al. Structure-based design of bitopic ligands for the µ-opioid receptor. Nature. PMID 36450356 DOI: 10.1038/s41586-022-05588-y |
0.765 |
|
| 2022 |
Kang W, Liu S, Xu J, Abrimian A, Malik AF, Chien R, Adaralegbe A, Amponsah A, Cartegni L, Pintar J, Pan YX. Exploring Pharmacological Functions of Alternatively Spliced Variants of the Mu Opioid Receptor Gene, , via Gene-Targeted Animal Models. International Journal of Molecular Sciences. 23. PMID 35328429 DOI: 10.3390/ijms23063010 |
0.714 |
|
| 2021 |
Chakraborty S, Uprety R, Slocum ST, Irie T, Le Rouzic V, Li X, Wilson LL, Scouller B, Alder AF, Kruegel AC, Ansonoff M, Varadi A, Eans SO, Hunkele A, Allaoa A, ... ... Pan YX, et al. Oxidative Metabolism as a Modulator of Kratom's Biological Actions. Journal of Medicinal Chemistry. PMID 34783240 DOI: 10.1021/acs.jmedchem.1c01111 |
0.829 |
|
| 2021 |
Liu S, Kang WJ, Abrimian A, Xu J, Cartegni L, Majumdar S, Hesketh P, Bekker A, Pan YX. Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, : Insight into Complex Mu Opioid Actions. Biomolecules. 11. PMID 34680158 DOI: 10.3390/biom11101525 |
0.883 |
|
| 2021 |
Bodnar RJ, Pan YX. Peptides Editorial: Opioid addiction: A 2021 update. Peptides. 146: 170668. PMID 34624430 DOI: 10.1016/j.peptides.2021.170668 |
0.471 |
|
| 2021 |
Chakraborty S, Uprety R, Daibani AE, Rouzic VL, Hunkele A, Appourchaux K, Eans SO, Nuthikattu N, Jilakara R, Thammavong L, Pasternak GW, Pan YX, McLaughlin JP, Che T, Majumdar S. Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom. Acs Chemical Neuroscience. PMID 34213886 DOI: 10.1021/acschemneuro.1c00149 |
0.883 |
|
| 2021 |
Standifer KM, Inturrisi CE, Foley KM, Pan YX. Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak. Cellular and Molecular Neurobiology. PMID 33978862 DOI: 10.1007/s10571-021-01097-0 |
0.641 |
|
| 2021 |
Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, LeRouzic V, Eans SO, Simons CA, ... ... Pan YX, et al. Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site. Elife. 10. PMID 33555255 DOI: 10.7554/eLife.56519 |
0.872 |
|
| 2020 |
Faouzi A, Uprety R, Gomes I, Massaly N, Keresztes AI, Le Rouzic V, Gupta A, Zhang T, Yoon HJ, Ansonoff M, Allaoa A, Pan YX, Pintar J, Morón JA, Streicher JM, et al. Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template. Journal of Medicinal Chemistry. PMID 33170687 DOI: 10.1021/acs.jmedchem.0c00901 |
0.854 |
|
| 2020 |
Narayan A, Hunkele A, Xu J, Bassoni DL, Pasternak GW, Pan YX. Correction to: Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1. Cellular and Molecular Neurobiology. PMID 33128690 DOI: 10.1007/s10571-020-00990-4 |
0.785 |
|
| 2020 |
Narayan A, Hunkle A, Xu J, Bassoni DL, Pasternak GW, Pan YX. Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1. Cellular and Molecular Neurobiology. PMID 33033993 DOI: 10.1007/s10571-020-00973-5 |
0.748 |
|
| 2020 |
Zhang T, Xu J, Pan YX. A truncated six transmembrane splice variant MOR-1G enhances expression of the full-length seven transmembrane mu opioid receptor through heterodimerization. Molecular Pharmacology. PMID 32723770 DOI: 10.1124/mol.120.119453 |
0.693 |
|
| 2020 |
Brown TG, Xu J, Hurd YL, Pan YX. Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats. Journal of Neuroscience Research. PMID 32506472 DOI: 10.1002/jnr.24640 |
0.557 |
|
| 2020 |
Grinnell SG, Uprety R, Varadi A, Subrath J, Hunkele A, Pan YX, Pasternak GW, Majumdar S. Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain. Cellular and Molecular Neurobiology. PMID 32424771 DOI: 10.1007/S10571-020-00867-6 |
0.877 |
|
| 2020 |
Lu Z, Xu J, Wang Q, Pan YX. Morphine modulates the expression of mu-opioid receptor exon 5-associated full-length C-terminal splice variants by upregulating miR-378a-3p. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31999011 DOI: 10.1096/fj.201901879RR |
0.47 |
|
| 2019 |
Gandini MA, Souza IA, Raval D, Xu J, Pan YX, Zamponi GW. Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors. Molecular Brain. 12: 98. PMID 31775826 DOI: 10.1186/S13041-019-0524-6 |
0.321 |
|
| 2019 |
Pasternak GW, Childers SR, Pan YX. Emerging Insights into Mu Opioid Pharmacology. Handbook of Experimental Pharmacology. PMID 31598835 DOI: 10.1007/164_2019_270 |
0.811 |
|
| 2019 |
Irie T, Shum R, Deni I, Hunkele A, Le Rouzic V, Xu J, Wilson R, Fischer G, Pasternak GW, Pan YX. Identification of abundant and evolutionarily conserved opioid receptor circular RNAs in the nervous system moduated by morphine. Molecular Pharmacology. PMID 31243060 DOI: 10.1124/Mol.118.113977 |
0.817 |
|
| 2018 |
Le Rouzic V, Narayan A, Hunkle A, Marrone GF, Lu Z, Majumdar S, Xu J, Pan YX, Pasternak GW. Pharmacological Characterization of Levorphanol, a G-Protein Biased Opioid Analgesic. Anesthesia and Analgesia. PMID 29649035 DOI: 10.1213/Ane.0000000000003360 |
0.868 |
|
| 2017 |
Huang XP, Che T, Mangano TJ, Le Rouzic V, Pan YX, Cameron MD, Baumann MH, Pasternak GW, Roth BL. Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo. Jci Insight. 2. PMID 29202454 DOI: 10.1172/Jci.Insight.97222 |
0.75 |
|
| 2017 |
Lu Z, Xu J, Xu M, Rossi GC, Majumdar S, Pasternak GW, Pan YX. Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia. Anesthesia and Analgesia. PMID 28991118 DOI: 10.1213/Ane.0000000000002538 |
0.851 |
|
| 2017 |
Baumann MH, Majumdar S, Le Rouzic V, Hunkele A, Uprety R, Huang XP, Xu J, Roth BL, Pan YX, Pasternak GW. Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neuropharmacology. PMID 28807672 DOI: 10.1016/J.Neuropharm.2017.08.016 |
0.865 |
|
| 2017 |
Pan L, Pasternak DA, Xu J, Xu M, Lu Z, Pasternak GW, Pan YX. Isolation and characterization of alternatively spliced variants of the mouse sigma1 receptor gene, Sigmar1. Plos One. 12: e0174694. PMID 28350844 DOI: 10.1371/Journal.Pone.0174694 |
0.665 |
|
| 2017 |
Marrone GF, Le Rouzic V, Varadi A, Xu J, Rajadhyaksha AM, Majumdar S, Pan YX, Pasternak GW. Genetic dissociation of morphine analgesia from hyperalgesia in mice. Psychopharmacology. PMID 28343361 DOI: 10.1007/S00213-017-4600-2 |
0.886 |
|
| 2017 |
Xu J, Lu Z, Narayan A, Le Rouzic VP, Xu M, Hunkele A, Brown TG, Hoefer WF, Rossi GC, Rice RC, Martínez-Rivera A, Rajadhyaksha AM, Cartegni L, Bassoni DL, Pasternak GW, ... Pan YX, et al. Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. The Journal of Clinical Investigation. PMID 28319053 DOI: 10.1172/Jci88760 |
0.734 |
|
| 2016 |
Marrone GF, Lu Z, Rossi G, Narayan A, Hunkele A, Marx S, Xu J, Pintar J, Majumdar S, Pan YX, Pasternak GW. Tetrapeptide endomorphin analogs require both full length and truncated splice variants of the mu opioid receptor gene Oprm1 for analgesia. Acs Chemical Neuroscience. PMID 27648914 DOI: 10.1021/Acschemneuro.6B00240 |
0.881 |
|
| 2016 |
Váradi A, Marrone GF, Palmer TC, Narayan A, Szabó MR, Le Rouzic V, Grinnell SG, Subrath JJ, Warner E, Kalra S, Hunkele A, Pagirsky J, Eans SO, Medina JM, Xu J, ... Pan YX, et al. Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism which do not recruit β-arrestin-2. Journal of Medicinal Chemistry. PMID 27556704 DOI: 10.1021/Acs.Jmedchem.6B00748 |
0.871 |
|
| 2016 |
Grinnell SG, Ansonoff M, Marrone GF, Lu Z, Narayan A, Xu J, Rossi G, Majumdar S, Pan YX, Bassoni DL, Pintar J, Pasternak G. Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants. Synapse (New York, N.Y.). PMID 27223691 DOI: 10.1002/Syn.21914 |
0.862 |
|
| 2016 |
Marrone GF, Grinnell SG, Lu Z, Rossi GC, Le Rouzic V, Xu J, Majumdar S, Pan YX, Pasternak GW. Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976581 DOI: 10.1073/Pnas.1523894113 |
0.872 |
|
| 2015 |
Lu Z, Xu J, Rossi GC, Majumdar S, Pasternak GW, Pan YX. Mediation of opioid analgesia by a truncated 6-transmembrane GPCR. The Journal of Clinical Investigation. PMID 26011641 DOI: 10.1172/Jci81070 |
0.894 |
|
| 2015 |
Xu J, Faskowitz AJ, Rossi GC, Xu M, Lu Z, Pan YX, Pasternak GW. Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs. Proceedings of the National Academy of Sciences of the United States of America. 112: 279-84. PMID 25535370 DOI: 10.1073/Pnas.1419183112 |
0.706 |
|
| 2014 |
Xu J, Lu Z, Xu M, Rossi GC, Kest B, Waxman AR, Pasternak GW, Pan YX. Differential expressions of the alternatively spliced variant mRNAs of the µ opioid receptor gene, OPRM1, in brain regions of four inbred mouse strains. Plos One. 9: e111267. PMID 25343478 DOI: 10.1371/Journal.Pone.0111267 |
0.613 |
|
| 2014 |
Xu J, Lu Z, Xu M, Pan L, Deng Y, Xie X, Liu H, Ding S, Hurd YL, Pasternak GW, Klein RJ, Cartegni L, Zhou W, Pan YX. A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11048-66. PMID 25122903 DOI: 10.1523/Jneurosci.3986-13.2014 |
0.543 |
|
| 2014 |
Wieskopf JS, Pan YX, Marcovitz J, Tuttle AH, Majumdar S, Pidakala J, Pasternak GW, Mogil JS. Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene. Pain. 155: 2063-70. PMID 25093831 DOI: 10.1016/J.Pain.2014.07.014 |
0.861 |
|
| 2014 |
Xu J, Xu M, Bolan E, Gilbert AK, Pasternak GW, Pan YX. Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P. Synapse (New York, N.Y.). 68: 144-52. PMID 24375714 DOI: 10.1002/Syn.21727 |
0.851 |
|
| 2014 |
Lu Z, Xu J, Xu M, Pasternak GW, Pan YX. Morphine regulates expression of μ-opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the μ-opioid receptor (OPRM1) gene via miR-103/miR-107. Molecular Pharmacology. 85: 368-80. PMID 24302561 DOI: 10.1124/Mol.113.089292 |
0.583 |
|
| 2013 |
Pasternak GW, Pan YX. Mu opioids and their receptors: evolution of a concept. Pharmacological Reviews. 65: 1257-317. PMID 24076545 DOI: 10.1124/Pr.112.007138 |
0.775 |
|
| 2013 |
Xu J, Xu M, Brown T, Rossi GC, Hurd YL, Inturrisi CE, Pasternak GW, Pan YX. Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action. The Journal of Biological Chemistry. 288: 21211-27. PMID 23760268 DOI: 10.1074/Jbc.M113.458687 |
0.759 |
|
| 2013 |
Sillivan SE, Whittard JD, Jacobs MM, Ren Y, Mazloom AR, Caputi FF, Horvath M, Keller E, Ma'ayan A, Pan YX, Chiang LW, Hurd YL. ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers. Biological Psychiatry. 74: 511-9. PMID 23702428 DOI: 10.1016/J.Biopsych.2013.04.012 |
0.471 |
|
| 2012 |
Majumdar S, Subrath J, Le Rouzic V, Polikar L, Burgman M, Nagakura K, Ocampo J, Haselton N, Pasternak AR, Grinnell S, Pan YX, Pasternak GW. Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants. Journal of Medicinal Chemistry. 55: 6352-62. PMID 22734622 DOI: 10.1021/Jm300305C |
0.854 |
|
| 2011 |
Majumdar S, Grinnell S, Le Rouzic V, Burgman M, Polikar L, Ansonoff M, Pintar J, Pan YX, Pasternak GW. Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects. Proceedings of the National Academy of Sciences of the United States of America. 108: 19778-83. PMID 22106286 DOI: 10.1073/Pnas.1115231108 |
0.866 |
|
| 2011 |
Pasternak G, Pan YX. Mu opioid receptors in pain management Acta Anaesthesiologica Taiwanica. 49: 21-25. PMID 21453899 DOI: 10.1016/J.Aat.2010.12.008 |
0.789 |
|
| 2011 |
Pasternak GW, Pan YX. Mix and match: heterodimers and opioid tolerance. Neuron. 69: 6-8. PMID 21318174 DOI: 10.1016/J.Neuron.2010.12.030 |
0.78 |
|
| 2011 |
Xu J, Xu M, Rossi GC, Pasternak GW, Pan YX. Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1. Molecular Pain. 7: 9. PMID 21255438 DOI: 10.1186/1744-8069-7-9 |
0.763 |
|
| 2009 |
Kolesnikov YA, Chereshnev I, Criesta M, Pan YX, Pasternak GW. Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice. Brain Research. 1289: 14-21. PMID 19545548 DOI: 10.1016/J.Brainres.2009.06.041 |
0.526 |
|
| 2009 |
Hadjimarkou MM, Abbadie C, Kasselman LJ, Pan YX, Pasternak GW, Bodnar RJ. Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats. Synapse (New York, N.Y.). 63: 585-97. PMID 19301417 DOI: 10.1002/Syn.20639 |
0.59 |
|
| 2009 |
Pan YX, Xu J, Xu M, Rossi GC, Matulonis JE, Pasternak GW. Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proceedings of the National Academy of Sciences of the United States of America. 106: 4917-22. PMID 19273844 DOI: 10.1073/Pnas.0811586106 |
0.775 |
|
| 2009 |
Xu J, Xu M, Hurd YL, Pasternak GW, Pan YX. Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene. Journal of Neurochemistry. 108: 962-72. PMID 19077058 DOI: 10.1111/J.1471-4159.2008.05833.X |
0.731 |
|
| 2006 |
Xu J, Xu M, Pan YX. Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic mice. Bmc Molecular Biology. 7: 41. PMID 17101047 DOI: 10.1186/1471-2199-7-41 |
0.388 |
|
| 2005 |
Pan YX, Xu J, Bolan E, Moskowitz HS, Xu M, Pasternak GW. Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing. Molecular Pharmacology. 68: 866-75. PMID 15939800 DOI: 10.1124/Mol.105.011858 |
0.85 |
|
| 2004 |
Pasternak DA, Pan L, Xu J, Yu R, Xu MM, Pasternak GW, Pan YX. Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy. Journal of Neurochemistry. 91: 881-90. PMID 15525342 DOI: 10.1111/J.1471-4159.2004.02767.X |
0.738 |
|
| 2004 |
Bolan EA, Pan YX, Pasternak GW. Functional analysis of MOR-1 splice variants of the mouse mu opioid receptor gene Oprm. Synapse (New York, N.Y.). 51: 11-8. PMID 14579421 DOI: 10.1002/Syn.10277 |
0.857 |
|
| 2003 |
Pan YX. Identification of alternatively spliced variants from opioid receptor genes Methods in Molecular Medicine. 84: 65-75. PMID 12703318 |
0.679 |
|
| 2003 |
Pan YX. Expression of opioid receptors in mammalian cell lines Methods in Molecular Medicine. 84: 17-28. PMID 12703313 |
0.592 |
|
| 2003 |
Pan YX. Molecular cloning of opioid receptors by cDNA library screening Methods in Molecular Medicine. 84: 3-16. PMID 12703312 |
0.559 |
|
| 2003 |
Pan YX, Xu J, Mahurter L, Xu M, Gilbert AK, Pasternak GW. Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X. Biochemical and Biophysical Research Communications. 301: 1057-61. PMID 12589820 DOI: 10.1016/S0006-291X(03)00089-5 |
0.704 |
|
| 2002 |
Pan YX, Bolan E, Pasternak GW. Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype. Biochemical and Biophysical Research Communications. 297: 659-63. PMID 12270145 DOI: 10.1016/S0006-291X(02)02258-1 |
0.875 |
|
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