| Year |
Citation |
Score |
| 2024 |
Kolic J, Sun WG, Cen HH, Ewald J, Rogalski JC, Sasaki S, Sun H, Rajesh V, Xia YH, Moravcova R, Skovsø S, Spigelman AF, Manning Fox JE, Lyon J, Beet L, ... ... MacDonald PE, et al. Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease. Medrxiv : the Preprint Server For Health Sciences. PMID 38496562 DOI: 10.1101/2023.05.24.23290298 |
0.401 |
|
| 2024 |
Lin H, Suzuki K, Smith N, Li X, Nalbach L, Fuentes S, Spigelman AF, Dai XQ, Bautista A, Ferdaoussi M, Aggarwal S, Pepper AR, Roma LP, Ampofo E, Li WH, ... MacDonald PE, et al. A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature Communications. 15: 334. PMID 38184650 DOI: 10.1038/s41467-023-44589-x |
0.355 |
|
| 2023 |
Coykendall VMN, Qian MF, Tellez K, Bautista A, Bevacqua RJ, Gu X, Hang Y, Neukam M, Zhao W, Chang C, MacDonald PE, Kim SK. RFX6 maintains gene expression and function of adult human islet α cells. Diabetes. PMID 38064570 DOI: 10.2337/db23-0483 |
0.365 |
|
| 2023 |
Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nature Communications. 14: 7732. PMID 38007492 DOI: 10.1038/s41467-023-43605-4 |
0.46 |
|
| 2023 |
Qian MF, Bevacqua RJ, Coykendall VM, Liu X, Zhao W, Chang CA, Gu X, Dai XQ, MacDonald PE, Kim SK. HNF1α maintains pancreatic α and β cell functions in primary human islets. Jci Insight. PMID 37943614 DOI: 10.1172/jci.insight.170884 |
0.443 |
|
| 2023 |
Chen YC, Taylor AJ, Fulcher JM, Swensen AC, Dai XQ, Komba M, Wrightson KLC, Fok K, Patterson AE, Klein-Geltink RI, MacDonald PE, Qian WJ, Verchere CB. Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing but does not lead to spontaneous development of diabetes in mice. Diabetes. PMID 37364047 DOI: 10.2337/db22-0945 |
0.353 |
|
| 2023 |
MacDonald PE, Rorsman P. Metabolic Messengers: glucagon. Nature Metabolism. PMID 36639733 DOI: 10.1038/s42255-022-00725-3 |
0.465 |
|
| 2023 |
Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, ... ... MacDonald PE, et al. Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia. PMID 36633628 DOI: 10.1007/s00125-022-05856-6 |
0.393 |
|
| 2022 |
Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, ... ... MacDonald PE, et al. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Nature Genetics. PMID 36543916 DOI: 10.1038/s41588-022-01261-2 |
0.358 |
|
| 2022 |
Alghamdi TA, Krentz NAJ, Smith N, Spigelman AF, Rajesh V, Jha A, Ferdaoussi M, Suzuki K, Yang J, Manning Fox JE, Sun H, Sun Z, Gloyn AL, MacDonald PE. Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding. Molecular Metabolism. 66: 101621. PMID 36307047 DOI: 10.1016/j.molmet.2022.101621 |
0.322 |
|
| 2022 |
Shrestha S, Erikson G, Lyon J, Spigelman AF, Bautista A, Manning Fox JE, Dos Santos C, Shokhirev M, Cartailler JP, Hetzer MW, MacDonald PE, Arrojo E Drigo R. Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress. Science Advances. 8: eabo3932. PMID 36197983 DOI: 10.1126/sciadv.abo3932 |
0.365 |
|
| 2022 |
Gosak M, Yan-Do R, Lin H, MacDonald PE, Stožer A. Ca2+ Oscillations, Waves, and Networks in Islets from Human Donors With and Without Type 2 Diabetes. Diabetes. PMID 36084321 DOI: 10.2337/db22-0004 |
0.336 |
|
| 2022 |
Stožer A, Šterk M, Paradiž Leitgeb E, Markovič R, Skelin Klemen M, Ellis CE, Križančić Bombek L, Dolenšek J, MacDonald PE, Gosak M. From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science. Frontiers in Endocrinology. 13: 922640. PMID 35784543 DOI: 10.3389/fendo.2022.922640 |
0.327 |
|
| 2022 |
Marcheva B, Weidemann BJ, Taguchi A, Perelis M, Ramsey KM, Newman MV, Kobayashi Y, Omura C, Manning Fox JE, Lin H, Macdonald PE, Bass J. P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure. Elife. 11. PMID 35188462 DOI: 10.7554/eLife.75132 |
0.332 |
|
| 2022 |
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, ... ... MacDonald PE, et al. Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance. Nature Communications. 13: 735. PMID 35136059 DOI: 10.1038/s41467-022-28039-8 |
0.426 |
|
| 2022 |
Marquez-Curtis LA, Dai XQ, Hang Y, Lam JY, Lyon J, Manning Fox JE, McGann LE, MacDonald PE, Kim SK, Elliott JAW. Cryopreservation and post-thaw characterization of dissociated human islet cells. Plos One. 17: e0263005. PMID 35081145 DOI: 10.1371/journal.pone.0263005 |
0.334 |
|
| 2021 |
Kim A, Knudsen JG, Madara JC, Benrick A, Hill T, Abdul-Kadir L, Kellard JA, Mellander L, Miranda C, Lin H, James T, Suba K, Spigelman AF, Wu Y, Macdonald PE, et al. Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes. Elife. 10. PMID 34787082 DOI: 10.7554/eLife.72919 |
0.421 |
|
| 2021 |
Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Alghamdi TA, Lewandowski SL, Jin Y, Bautista A, Wang YW, Manning Fox JE, Merrins MJ, Buteau J, MacDonald PE. β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High Fat Diet-Fed Mice. Diabetes. PMID 34462260 DOI: 10.2337/db20-1235 |
0.406 |
|
| 2021 |
Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SC, MacDonald PE, Levy SE, et al. Combinatorial transcription factor profiles predict mature and functional human islet α and β cells. Jci Insight. PMID 34428183 DOI: 10.1172/jci.insight.151621 |
0.363 |
|
| 2021 |
Wang S, Flibotte S, Camunas-Soler J, MacDonald PE, Johnson JD. A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data. Canadian Journal of Diabetes. PMID 34052132 DOI: 10.1016/j.jcjd.2021.03.007 |
0.336 |
|
| 2021 |
Bevacqua RJ, Dai X, Lam JY, Gu X, Friedlander MSH, Tellez K, Miguel-Escalada I, Bonàs-Guarch S, Atla G, Zhao W, Kim SH, Dominguez AA, Qi LS, Ferrer J, MacDonald PE, et al. CRISPR-based genome editing in primary human pancreatic islet cells. Nature Communications. 12: 2397. PMID 33893274 DOI: 10.1038/s41467-021-22651-w |
0.384 |
|
| 2021 |
Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, ... ... MacDonald PE, et al. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nature Metabolism. PMID 33536639 DOI: 10.1038/s42255-021-00347-1 |
0.376 |
|
| 2020 |
Nalbach L, Roma LP, Schmitt BM, Becker V, Körbel C, Wrublewsky S, Pack M, Später T, Metzger W, Menger MM, Frueh FS, Götz C, Lin H, Em Fox J, MacDonald PE, et al. Improvement of islet transplantation by the fusion of islet cells with functional blood vessels. Embo Molecular Medicine. e12616. PMID 33135383 DOI: 10.15252/emmm.202012616 |
0.386 |
|
| 2020 |
Marcheva B, Perelis M, Weidemann BJ, Taguchi A, Lin H, Omura C, Kobayashi Y, Newman MV, Wyatt EJ, McNally EM, Fox JEM, Hong H, Shankar A, Wheeler EC, Ramsey KM, ... MacDonald PE, et al. A role for alternative splicing in circadian control of exocytosis and glucose homeostasis. Genes & Development. PMID 32616519 DOI: 10.1101/Gad.338178.120 |
0.389 |
|
| 2020 |
Campbell SA, Golec D, Hubert M, Johnson J, Salamon N, Barr A, MacDonald PE, Philippaert K, Light PE. Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes. Molecular Metabolism. 101014. PMID 32413586 DOI: 10.1016/j.molmet.2020.101014 |
0.384 |
|
| 2020 |
Ferdaoussi M, Smith N, Lin H, Bautista A, Spigelman AF, Lyon J, Dai X, Manning Fox JE, MacDonald PE. Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion. Physiological Reports. 8: e14420. PMID 32339440 DOI: 10.14814/phy2.14420 |
0.475 |
|
| 2020 |
Camunas-Soler J, Dai XQ, Hang Y, Bautista A, Lyon J, Suzuki K, Kim SK, Quake SR, MacDonald PE. Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes. Cell Metabolism. PMID 32302527 DOI: 10.1016/J.Cmet.2020.04.005 |
0.375 |
|
| 2020 |
Armour SL, Anderson SJ, Richardson SJ, Ding Y, Carey C, Lyon J, Maheshwari RR, Al-Jahdami N, Krasnogor N, Morgan NG, MacDonald P, Shaw JAM, White MG. Reduced expression of the co-regulator TLE1 in type 2 diabetes is associated with increased islet α-cell number. Endocrinology. PMID 32065829 DOI: 10.1210/endocr/bqaa011 |
0.398 |
|
| 2020 |
Ackeifi C, Wang P, Karakose E, Manning Fox JE, González BJ, Liu H, Wilson J, Swartz E, Berrouet C, Li Y, Kumar K, MacDonald PE, Sanchez R, Thorens B, DeVita R, et al. GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration. Science Translational Medicine. 12. PMID 32051230 DOI: 10.1126/Scitranslmed.Aaw9996 |
0.379 |
|
| 2019 |
Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE. A role for PKD1 in insulin secretion downstream of P2Y receptor activation in mouse and human islets. Physiological Reports. 7: e14250. PMID 31591827 DOI: 10.14814/Phy2.14250 |
0.455 |
|
| 2019 |
Fu J, Githaka JM, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Manning Fox JE, Gaisano HY, MacDonald PE. A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes. Jci Insight. 5. PMID 31085831 DOI: 10.1172/jci.insight.127896 |
0.452 |
|
| 2019 |
Capozzi ME, Svendsen B, Encisco SE, Lewandowski SL, Martin MD, Lin H, Jaffe JL, Coch RW, Haldeman JM, MacDonald PE, Merrins MJ, D'Alessio DA, Campbell JE. β-Cell tone is defined by proglucagon peptides through cyclic AMP signaling. Jci Insight. PMID 30720465 DOI: 10.1172/jci.insight.126742 |
0.48 |
|
| 2018 |
Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, ... ... MacDonald PE, et al. Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. Nature Genetics. PMID 30054598 DOI: 10.1038/s41588-018-0173-1 |
0.454 |
|
| 2018 |
Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, ... ... MacDonald PE, et al. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. Jci Insight. 3. PMID 29669939 DOI: 10.1172/Jci.Insight.98240 |
0.377 |
|
| 2018 |
Tokarz VL, MacDonald PE, Klip A. The cell biology of systemic insulin function. The Journal of Cell Biology. PMID 29622564 DOI: 10.1083/Jcb.201802095 |
0.449 |
|
| 2017 |
Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E. Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. The Journal of Clinical Investigation. PMID 29106387 DOI: 10.1172/JCI90004 |
0.341 |
|
| 2017 |
Jensen MV, Gooding JR, Ferdaoussi M, Dai XQ, Peterson BS, MacDonald PE, Newgard CB. Metabolomics applied to islet nutrient sensing mechanisms. Diabetes, Obesity & Metabolism. 19: 90-94. PMID 28880482 DOI: 10.1111/Dom.13010 |
0.416 |
|
| 2017 |
Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE. Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction. Diabetes. PMID 28607108 DOI: 10.2337/Db16-1170 |
0.408 |
|
| 2017 |
Pepper AR, Pawlick R, Bruni A, Wink J, Rafiei Y, O'Gorman D, Yan-Do R, Gala-Lopez B, Kin T, MacDonald PE, Shapiro AMJ. Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site. Stem Cell Reports. 8: 1689-1700. PMID 28591651 DOI: 10.1016/j.stemcr.2017.05.004 |
0.455 |
|
| 2017 |
Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Fox JEM, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, et al. N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes. Cell Metabolism. 25: 1334-1347.e4. PMID 28591636 DOI: 10.1016/j.cmet.2017.04.012 |
0.434 |
|
| 2017 |
Gordon HM, Majithia N, MacDonald PE, Fox JE, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS. STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation. Endocrine. PMID 28405880 DOI: 10.1007/S12020-017-1297-2 |
0.333 |
|
| 2017 |
Ferdaoussi M, Fu J, Dai X, Manning Fox JE, Suzuki K, Smith N, Plummer G, MacDonald PE. SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells. Scientific Reports. 7: 248. PMID 28325894 DOI: 10.1038/s41598-017-00344-z |
0.379 |
|
| 2017 |
Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, et al. Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx. Cell Metabolism. PMID 28215845 DOI: 10.1016/J.Cmet.2017.01.009 |
0.405 |
|
| 2017 |
Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, ... ... MacDonald PE, et al. Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. American Journal of Human Genetics. PMID 28132686 DOI: 10.1016/J.Ajhg.2017.01.011 |
0.462 |
|
| 2016 |
Hamza SM, Sung MM, Gao F, Soltys CL, Smith NP, MacDonald PE, Light PE, Dyck JR. Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats. Biochimica Et Biophysica Acta. PMID 27871838 DOI: 10.1016/j.bbagen.2016.11.029 |
0.393 |
|
| 2016 |
Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE. Interleukin-1 signaling contributes to acute islet compensation. Jci Insight. 1: e86055. PMID 27699257 DOI: 10.1172/jci.insight.86055 |
0.31 |
|
| 2016 |
Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attané C, Moullé VS, MacDonald PE, Ghislain J, Poitout V. Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease. The Journal of Clinical Investigation. PMID 27525435 DOI: 10.1172/Jci86181 |
0.412 |
|
| 2016 |
Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE. PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets. Molecular Metabolism. 5: 459-71. PMID 27408772 DOI: 10.1016/J.Molmet.2016.05.003 |
0.441 |
|
| 2016 |
Yan-Do R, Duong E, Manning Fox JE, Dai X, Suzuki K, Khan S, Bautista A, Ferdaoussi M, Lyon J, Wu X, Cheley S, MacDonald PE, Braun M. A glycine-insulin autocrine feedback loop enhances insulin secretion from human β-cells and is impaired in type 2 diabetes. Diabetes. PMID 27207556 DOI: 10.2337/db15-1272 |
0.508 |
|
| 2015 |
Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AM, Rajotte RV, MacDonald PE. Research-focused isolation of human islets from donors with and without diabetes at the Alberta Diabetes Institute IsletCore. Endocrinology. en20151562. PMID 26653569 DOI: 10.1210/en.2015-1562 |
0.311 |
|
| 2015 |
Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ. TCF1 links GIPR signaling to the control of beta cell function and survival. Nature Medicine. PMID 26642437 DOI: 10.1038/Nm.3997 |
0.377 |
|
| 2015 |
van de Bunt M, Manning Fox JE, Dai X, Barrett A, Grey C, Li L, Bennett AJ, Johnson PR, Rajotte RV, Gaulton KJ, Dermitzakis ET, MacDonald PE, McCarthy MI, Gloyn AL. Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors. Plos Genetics. 11: e1005694. PMID 26624892 DOI: 10.1371/Journal.Pgen.1005694 |
0.414 |
|
| 2015 |
Gala-Lopez BL, Pepper AR, Pawlick RL, O'Gorman D, Kin T, Bruni A, Abualhassan N, Bral M, Bautista A, Manning Fox JE, Young LG, MacDonald PE, Shapiro A. Anti-aging Glycopeptide Protects Human Islets Against Tacrolimus-related Injury and Facilitates Engraftment in Mice. Diabetes. PMID 26581595 DOI: 10.2337/db15-0764 |
0.386 |
|
| 2015 |
Gooding JR, Jensen MV, Dai X, Wenner BR, Lu D, Arumugam R, Ferdaoussi M, MacDonald PE, Newgard CB. Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism. Cell Reports. PMID 26411681 DOI: 10.1016/J.Celrep.2015.08.072 |
0.46 |
|
| 2015 |
Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, ... ... MacDonald PE, et al. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. The Journal of Clinical Investigation. PMID 26389676 DOI: 10.1172/Jci82498 |
0.504 |
|
| 2015 |
Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG. Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion. Molecular Endocrinology (Baltimore, Md.). 29: 988-1005. PMID 26061564 DOI: 10.1210/Me.2014-1330 |
0.379 |
|
| 2015 |
Fu A, Robitaille K, Faubert B, Reeks C, Dai XQ, Hardy AB, Sankar KS, Ogrel S, Al-Dirbashi OY, Rocheleau JV, Wheeler MB, MacDonald PE, Jones R, Screaton RA. LKB1 couples glucose metabolism to insulin secretion in mice. Diabetologia. 58: 1513-22. PMID 25874445 DOI: 10.1007/S00125-015-3579-7 |
0.445 |
|
| 2014 |
Kushner JA, MacDonald PE, Atkinson MA. Stem cells to insulin secreting cells: two steps forward and now a time to pause? Cell Stem Cell. 15: 535-6. PMID 25517460 DOI: 10.1016/J.Stem.2014.10.012 |
0.43 |
|
| 2014 |
Kolic J, Spigelman AF, Smith AM, Manning Fox JE, MacDonald PE. Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells. The Journal of Biological Chemistry. 289: 32109-20. PMID 25288806 DOI: 10.1074/jbc.M114.577510 |
0.42 |
|
| 2014 |
Patterson JN, Cousteils K, Lou JW, Manning Fox JE, MacDonald PE, Joseph JW. Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 289: 13335-46. PMID 24675076 DOI: 10.1074/jbc.M113.521666 |
0.458 |
|
| 2014 |
Gutierrez-Aguilar R, Kim DH, Casimir M, Dai XQ, Pfluger PT, Park J, Haller A, Donelan E, Park J, D'Alessio D, Woods SC, MacDonald PE, Seeley RJ. The role of the transcription factor ETV5 in insulin exocytosis. Diabetologia. 57: 383-91. PMID 24190582 DOI: 10.1007/S00125-013-3096-5 |
0.43 |
|
| 2013 |
Yang YH, Manning Fox JE, Zhang KL, MacDonald PE, Johnson JD. Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. 110: 16480-5. PMID 24065825 DOI: 10.1073/Pnas.1214312110 |
0.328 |
|
| 2013 |
Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AM, Korbutt G, MacDonald PE. Functional plasticity of the human infant β-cell exocytotic phenotype. Endocrinology. 154: 1392-9. PMID 23449893 DOI: 10.1210/en.2012-1934 |
0.334 |
|
| 2012 |
Gaisano HY, Macdonald PE, Vranic M. Glucagon secretion and signaling in the development of diabetes. Frontiers in Physiology. 3: 349. PMID 22969729 DOI: 10.3389/Fphys.2012.00349 |
0.468 |
|
| 2012 |
Kailey B, van de Bunt M, Cheley S, Johnson PR, MacDonald PE, Gloyn AL, Rorsman P, Braun M. SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells. American Journal of Physiology. Endocrinology and Metabolism. 303: E1107-16. PMID 22932785 DOI: 10.1152/Ajpendo.00207.2012 |
0.326 |
|
| 2012 |
Cai EP, Casimir M, Schroer SA, Luk CT, Shi SY, Choi D, Dai XQ, Hajmrle C, Spigelman AF, Zhu D, Gaisano HY, MacDonald PE, Woo M. In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes. 61: 1708-18. PMID 22498697 DOI: 10.2337/Db11-1344 |
0.461 |
|
| 2011 |
Kruit JK, Wijesekara N, Fox JE, Dai XQ, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Bhattacharjee A, Johnson JD, Light PE, Marsh BJ, Macdonald PE, Verchere CB, et al. Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. Diabetes. 60: 3186-96. PMID 21998401 DOI: 10.2337/Db11-0081 |
0.45 |
|
| 2011 |
Dai XQ, Plummer G, Casimir M, Kang Y, Hajmrle C, Gaisano HY, Manning Fox JE, MacDonald PE. SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans Diabetes. 60: 838-847. PMID 21266332 DOI: 10.2337/Db10-0440 |
0.496 |
|
| 2011 |
MacDonald P. Control of secretory granule access to the plasma membrane by PI3 kinase-γ. Islets. 1: 266-8. PMID 21099282 DOI: 10.4161/isl.1.3.9678 |
0.355 |
|
| 2010 |
Hamming KS, Soliman D, Webster NJ, Searle GJ, Matemisz LC, Liknes DA, Dai XQ, Pulinilkunnil T, Riedel MJ, Dyck JR, Macdonald PE, Light PE. Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion. Diabetes. 59: 1686-93. PMID 20413506 DOI: 10.2337/db09-0630 |
0.316 |
|
| 2009 |
Hardy AB, Fox JE, Giglou PR, Wijesekara N, Bhattacharjee A, Sultan S, Gyulkhandanyan AV, Gaisano HY, MacDonald PE, Wheeler MB. Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets. The Journal of Biological Chemistry. 284: 30441-52. PMID 19690348 DOI: 10.1074/Jbc.M109.040659 |
0.433 |
|
| 2009 |
Pigeau GM, Kolic J, Ball BJ, Hoppa MB, Wang YW, Rückle T, Woo M, Manning Fox JE, MacDonald PE. Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells. Diabetes. 58: 2084-92. PMID 19549714 DOI: 10.2337/Db08-1371 |
0.354 |
|
| 2008 |
Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE. K(ATP)-channels and glucose-regulated glucagon secretion. Trends in Endocrinology and Metabolism: Tem. 19: 277-84. PMID 18771934 DOI: 10.1016/J.Tem.2008.07.003 |
0.362 |
|
| 2007 |
MacDonald PE, De Marinis YZ, Ramracheya R, Salehi A, Ma X, Johnson PR, Cox R, Eliasson L, Rorsman P. A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. Plos Biology. 5: e143. PMID 17503968 DOI: 10.1371/Journal.Pbio.0050143 |
0.327 |
|
| 2007 |
MacDonald PE, Rorsman P. The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. Physiology (Bethesda, Md.). 22: 113-21. PMID 17420302 DOI: 10.1152/Physiol.00047.2006 |
0.307 |
|
| 2006 |
Li LX, MacDonald PE, Ahn DS, Oudit GY, Backx PH, Brubaker PL. Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1. Endocrinology. 147: 3318-25. PMID 16574789 DOI: 10.1210/En.2006-0155 |
0.401 |
|
| 2006 |
MacDonald PE, Rorsman P. Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells. Plos Biology. 4: e49. PMID 16464129 DOI: 10.1371/Journal.Pbio.0040049 |
0.422 |
|
| 2005 |
MacDonald PE, Joseph JW, Rorsman P. Glucose-sensing mechanisms in pancreatic beta-cells. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 360: 2211-25. PMID 16321791 DOI: 10.1098/Rstb.2005.1762 |
0.416 |
|
| 2004 |
Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 432: 226-30. PMID 15538371 DOI: 10.1038/Nature03076 |
0.307 |
|
| 2002 |
MacDonald PE, El-Kholy W, Riedel MJ, Salapatek AM, Light PE, Wheeler MB. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes. 51: S434-42. PMID 12475787 |
0.398 |
|
| 2002 |
MacDonald PE, Sewing S, Wang J, Joseph JW, Smukler SR, Sakellaropoulos G, Saleh MC, Chan CB, Tsushima RG, Salapatek AMF, Wheeler MB. Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic β-cells enhances glucose-dependent insulin secretion Journal of Biological Chemistry. 277: 44938-44945. PMID 12270920 DOI: 10.1074/jbc.M205532200 |
0.398 |
|
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