| Year |
Citation |
Score |
| 2022 |
Cai X, Patel S, Huang C, Paiva A, Sun Y, Barker G, Weller H, Shou W. Comprehensive Characterization and Optimization of Caco-2 Cells Enabled the Development of a Miniaturized 96-well Permeability Assay. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-30. PMID 36217915 DOI: 10.1080/00498254.2022.2133648 |
0.287 |
|
| 2021 |
Barhate CL, Donnell AF, Davies M, Li L, Zhang Y, Yang F, Black R, Zipp G, Zhang Y, Cavallaro CL, Priestley ES, Weller HN. Microscale purification in support of high-throughput medicinal chemistry. Chemical Communications (Cambridge, England). PMID 34608906 DOI: 10.1039/d1cc03791a |
0.31 |
|
| 2020 |
Zhang J, Pikul G, Horch J, Konovalov D, Li S, Cvijic ME, Shou W, Weller H. Enabling direct and definitive free fraction determination for highly-bound compounds in protein binding assay. Journal of Pharmaceutical and Biomedical Analysis. 113765. PMID 33272788 DOI: 10.1016/j.jpba.2020.113765 |
0.329 |
|
| 2020 |
Zhang J, Zhang Y, Liu C, Covey T, Nielsen J, Li S, Weller H, Shou W. Acoustic Ejection/Full-Scan Mass Spectrometry Analysis for High-Throughput Compound Quality Control. Slas Technology. 2472630320967625. PMID 33196338 DOI: 10.1177/2472630320967625 |
0.325 |
|
| 2020 |
Shou WZ, Gerritz SW, Harden D, Lawrence RM, Chase P, Chin J, Surti N, Lippy JS, Weller HN, Nielsen J, Weerakoon D. Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging. Slas Discovery : Advancing Life Sciences R & D. 2472555220919097. PMID 32400264 DOI: 10.1177/2472555220919097 |
0.301 |
|
| 2019 |
Zhang J, Shou W, Ogura T, Li S, Weller H. Optimization of microflow LC-MS/MS and its utility in quantitative discovery bioanalysis. Bioanalysis. 11: 1117-1127. PMID 31251100 DOI: 10.4155/bio-2019-0076 |
0.275 |
|
| 2019 |
Cai X, Madari S, Walker A, Paiva A, Li Y, Herbst J, Shou W, Weller H. Addition of Optimized Bovine Serum Albumin Level in a High-Throughput Caco-2 Assay Enabled Accurate Permeability Assessment for Lipophilic Compounds. Slas Discovery : Advancing Life Sciences R & D. 2472555219848483. PMID 31076010 DOI: 10.1177/2472555219848483 |
0.322 |
|
| 2015 |
Leet JE, Belcastro JV, Dowling CJ, Nemeth GA, Weller HN. HPLC biogram analysis: a powerful tool used for hit confirmation in early drug discovery. Journal of Biomolecular Screening. 20: 681-7. PMID 25681433 DOI: 10.1177/1087057115569160 |
0.293 |
|
| 2014 |
Vath M, Gallagher L, Shou W, Weller H, Elkin L, Zhang J. Development of an LC-MS/MS method for high throughput quantification of metformin uptake in transporter inhibition assays. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 967: 211-8. PMID 25125398 DOI: 10.1016/j.jchromb.2014.07.024 |
0.303 |
|
| 2014 |
Ebinger K, Weller HN. Comparative assessment of achiral stationary phases for high throughput analysis in supercritical fluid chromatography. Journal of Chromatography. A. 1332: 73-81. PMID 24508356 DOI: 10.1016/j.chroma.2014.01.060 |
0.263 |
|
| 2013 |
Zhang J, Vath M, Ferraro C, Li Y, Murphy K, Zvyaga T, Weller H, Shou W. A high-speed liquid chromatography/tandem mass spectrometry platform using multiplexed multiple-injection chromatography controlled by single software and its application in discovery ADME screening. Rapid Communications in Mass Spectrometry : Rcm. 27: 731-7. PMID 23495019 DOI: 10.1002/rcm.6514 |
0.261 |
|
| 2013 |
Ebinger K, Weller HN. Comparison of chromatographic techniques for diastereomer separation of a diverse set of drug-like compounds. Journal of Chromatography. A. 1272: 150-4. PMID 23261288 DOI: 10.1016/j.chroma.2012.11.065 |
0.272 |
|
| 2012 |
Weller HN, Nirschl DS, Paulson JL, Hoffman SL, Bullock WH. Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification. Acs Combinatorial Science. 14: 520-6. PMID 22909004 DOI: 10.1021/co300075g |
0.228 |
|
| 2012 |
Cai X, Walker A, Cheng C, Paiva A, Li Y, Kolb J, Herbst J, Shou W, Weller H. Approach to improve compound recovery in a high-throughput Caco-2 permeability assay supported by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical Sciences. 101: 2755-62. PMID 22611052 DOI: 10.1002/jps.23194 |
0.33 |
|
| 2012 |
Zhang J, Maloney J, Drexler DM, Cai X, Stewart J, Mayer C, Herbst J, Weller H, Shou WZ. Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays. Bioanalysis. 4: 581-93. PMID 22409555 DOI: 10.4155/bio.12.2 |
0.305 |
|
| 2011 |
Ebinger K, Weller HN, Kiplinger J, Lefebvre P. Evaluation of a new preparative supercritical fluid chromatography system for compound library purification: the TharSFC SFC-MS Prep-100 system. Journal of Laboratory Automation. 16: 241-9. PMID 21609708 DOI: 10.1016/j.jala.2010.03.005 |
0.297 |
|
| 2011 |
Wagner AD, Kolb JM, Ozbal CC, Herbst JJ, Olah TV, Weller HN, Zvyaga TA, Shou WZ. Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen. Rapid Communications in Mass Spectrometry : Rcm. 25: 1231-40. PMID 21488121 DOI: 10.1002/rcm.4984 |
0.289 |
|
| 2010 |
Zhang J, Shou WZ, Vath M, Kieltyka K, Maloney J, Elvebak L, Stewart J, Herbst J, Weller HN. An integrated bioanalytical platform for supporting high-throughput serum protein binding screening. Rapid Communications in Mass Spectrometry : Rcm. 24: 3593-601. PMID 21080511 DOI: 10.1002/rcm.4817 |
0.302 |
|
| 2010 |
Weller HN, Ebinger K, Bullock W, Edinger KJ, Hermsmeier MA, Hoffman SL, Nirschl DS, Swann T, Zhao J, Kiplinger J, Lefebvre P. Orthogonality of SFC versus HPLC for small molecule library separation. Journal of Combinatorial Chemistry. 12: 877-82. PMID 20923153 DOI: 10.1021/cc100118y |
0.309 |
|
| 2010 |
Han Y, Ebinger K, Vandevier LE, Maloney JW, Nirschl DS, Weller HN. Efficient and library-friendly synthesis of furo- and thieno[2,3-d] pyrimidin-4-amine derivatives by microwave irradiation Tetrahedron Letters. 51: 629-632. DOI: 10.1016/j.tetlet.2009.11.071 |
0.254 |
|
| 2009 |
Kieltyka K, Zhang J, Li S, Vath M, Baglieri C, Ferraro C, Zvyaga TA, Drexler DM, Weller HN, Shou WZ. A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen. Rapid Communications in Mass Spectrometry : Rcm. 23: 1579-91. PMID 19399765 DOI: 10.1002/rcm.4037 |
0.312 |
|
| 2006 |
Weller HN, Nirschl DS, Petrillo EW, Poss MA, Andres CJ, Cavallaro CL, Echols MM, Grant-Young KA, Houston JG, Miller AV, Swann RT. Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis. Journal of Combinatorial Chemistry. 8: 664-9. PMID 16961404 DOI: 10.1021/cc050164h |
0.243 |
|
| 2005 |
Weller HN, Rubin EA, Moshiri B, Ruediger W, Li WJ, Allen J, Nolfo J, Bertok A, Rosso VW. Development and commercialization of the MiniBlock synthesizer family: A historical case study Jala - Journal of the Association For Laboratory Automation. 10: 59-71. DOI: 10.1016/j.jala.2004.07.002 |
0.219 |
|
| 1998 |
Weller HN. Purification of combinatorial libraries. Molecular Diversity. 4: 47-52. PMID 10320989 |
0.3 |
|
| 1997 |
Weller HN, Young MG, Michalczyk SJ, Reitnauer GH, Cooley RS, Rahn PC, Loyd DJ, Fiore D, Fischman SJ. High throughput analysis and purification in support of automated parallel synthesis. Molecular Diversity. 3: 61-70. PMID 9527477 |
0.318 |
|
| 1997 |
Neil W, Weller HN, Michael Lawrence R, Young MG. Adaptation of liquid handlers to the automation of combinatorial organic chemistry American Biotechnology Laboratory. 15: 48-49. |
0.205 |
|
| 1996 |
Leftheris K, Kline T, Vite GD, Cho YH, Bhide RS, Patel DV, Patel MM, Schmidt RJ, Weller HN, Andahazy ML, Carboni JM, Gullo-Brown JL, Lee FY, Ricca C, Rose WC, et al. Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. Journal of Medicinal Chemistry. 39: 224-36. PMID 8568812 DOI: 10.1021/Jm950642A |
0.368 |
|
| 1996 |
Lawrence RM, Fryszman OM, Poss MA, Biller SA, Weller HN. Automated preparation and purification of amides American Biotechnology Laboratory. 14: 10-15. |
0.285 |
|
| 1995 |
Patel DV, Gordon EM, Schmidt RJ, Weller HN, Young MG, Zahler R, Barbacid M, Carboni JM, Gullo-Brown JL, Hunihan L. Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase. Journal of Medicinal Chemistry. 38: 435-42. PMID 7853336 DOI: 10.1021/Jm00003A006 |
0.402 |
|
| 1994 |
Robl JA, Cimarusti MP, Simpkins LM, Weller HN, Pan YY, Malley M, DiMarco JD. Peptidomimetic synthesis: A novel, highly stereoselective route to substituted freidinger lactams Journal of the American Chemical Society. 116: 2348-2355. |
0.29 |
|
| 1993 |
Kim KS, Qian L, Bird JE, Dickinson KE, Moreland S, Schaeffer TR, Waldron TL, Delaney CL, Weller HN, Miller AV. Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships. Journal of Medicinal Chemistry. 36: 2335-42. PMID 8360878 |
0.317 |
|
| 1993 |
Poss MA, Reid JA, Free CA, Rogers WL, Weber H, Ryono DE, Dejneka T, DeForrest JM, Waldron TL, Brittain RJ, Weller HN, Cimarusti MP, Petrillo EW. Diol sulfonamides: A potent and novel class of inhibitors of human renin Bioorganic and Medicinal Chemistry Letters. 3: 2739-2744. DOI: 10.1016/S0960-894X(01)80755-1 |
0.268 |
|
| 1993 |
Weller HN, Miller AV, Dickinson KEJ, Hedberg SA, Delaney CL, Serafino RP, Moreland S. Synthesis of N-alkyl-1,2,4-oxadiazinones as angiotensin-II (at1) receptor antagonists Heterocycles. 36: 1027-1038. |
0.242 |
|
| 1992 |
Atwal KS, Ahmed SZ, Bird JE, Delaney CL, Dickinson KEJ, Ferrara FN, Hedberg A, Miller AV, Moreland S, O'Reilly BC, Schaeffer TR, Waldron TL, Weller HN. Dihydropyrimidine angiotensin II receptor antagonists Journal of Medicinal Chemistry. 35: 4751-4763. PMID 1469703 DOI: 10.1021/jm00103a014 |
0.292 |
|
| 1992 |
Weller HN, Miller AV, Moquin RV, Dickinson KEJ, Hedberg SA, Moreland S, Cohen RB, Delaney CL, Skwish S, Williams S. Benzothiadiazine dioxides: A new class of potent angiotensin-II (AT1) receptor antagonists Bioorganic and Medicinal Chemistry Letters. 2: 1115-1120. DOI: 10.1016/S0960-894X(00)80630-7 |
0.235 |
|
| 1989 |
DeForrest JM, Waldron TL, Oehl RS, Scalese RJ, Free CA, Weller HN, Ryono DE. Pharmacology of novel imidazole alcohol inhibitors of primate renin. Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension. 7: S15-9. PMID 2666607 |
0.298 |
|
| 1988 |
Natarajan S, Gordon EM, Sabo EF, Godfrey JD, Weller HN, Pluscec J, Rom MB, Engebrecht J, Cushman DW, Deforrest JM. Ketomethylureas. A new class of angiotensin converting enzyme inhibitors. Journal of Enzyme Inhibition. 2: 91-7. PMID 3236070 DOI: 10.3109/14756368809040715 |
0.407 |
|
| 1988 |
Weller HN, Rom MB. Cyclic (hydroxyphosphinyl)acyl dipeptides: a new class of angiotensin converting enzyme inhibitors. Journal of Enzyme Inhibition. 2: 183-98. PMID 3071574 DOI: 10.3109/14756368809040725 |
0.39 |
|
| 1986 |
Gordon EM, Godfrey JD, Weller HN, Natarajan S, Pluščec J, Rom MB, Niemela K, Sabo EF, Cushman DW. Design of tripeptide modeled inhibitors of angiotensin-converting enzyme: Studies on the role of the N-terminal acylamino group Bioorganic Chemistry. 14: 148-156. DOI: 10.1016/0045-2068(86)90024-6 |
0.398 |
|
| 1984 |
Weller HN, Gordon EM, Rom MB, Pluscec J. Design of conformationally constrained angiotensin-converting enzyme inhibitors. Biochemical and Biophysical Research Communications. 125: 82-9. PMID 6095846 DOI: 10.1016/S0006-291X(84)80337-X |
0.393 |
|
| 1984 |
Gordon EM, Natarajan S, Pluscec J, Weller HN, Godfrey JD, Rom MB, Sabo EF, Engebrecht J, Cushman DW. Ketomethyldipeptides II. Effect of modifications of the alpha-aminoketone portion on inhibition of angiotensin converting enzyme. Biochemical and Biophysical Research Communications. 124: 148-55. PMID 6093783 DOI: 10.1016/0006-291X(84)90929-X |
0.395 |
|
| 1984 |
Natarajan S, Gordon EM, Sabo EF, Godfrey JD, Weller HN, Pluscec J, Rom MB, Cushman DW. Ketomethyldipeptides I. A new class of angiotensin converting enzyme inhibitors. Biochemical and Biophysical Research Communications. 124: 141-7. PMID 6093782 DOI: 10.1016/0006-291X(84)90928-8 |
0.402 |
|
| 1984 |
STEVENS RV, CHANG JH, LAPALME R, SCHOW S, SCHLAGETER MG, SHAPIRO R, WELLER HN. ChemInform Abstract: STUDIES ON THE SYNTHESIS OF VITAMIN B-12. 3 Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198414346 |
0.209 |
|
| 1982 |
Weller HN, Gordon EM. Absolute configuration of 2-amino-4-phenyl butyric acid The Journal of Organic Chemistry. 47: 4160-4161. DOI: 10.1021/Jo00142A030 |
0.329 |
|
| 1982 |
Weller HN, Gordon EM. Absolute configuration of 2-amino-4-phenylbutyric acid (homophenylalanine) Journal of Organic Chemistry. 47: 4160-4161. |
0.221 |
|
| 1980 |
Stevens RV, Chapman KT, Weller HN. Convenient and inexpensive procedure for oxidation of secondary alcohols to ketones Journal of Organic Chemistry. 45: 2030-2032. DOI: 10.1021/Jo01298A066 |
0.454 |
|
| 1978 |
Semmelhack MF, Weller HN, Clardy J. Rapid vinyl shifts in spiro[4.4]polyenes: Verification of the rate-determining step and the identity of the migrating group Journal of Organic Chemistry. 43: 3791-3792. DOI: 10.1021/Jo00413A042 |
0.489 |
|
| 1977 |
SEMMELHACK MF, WELLER HN, FOOS JS. ChemInform Abstract: THERMAL REARRANGEMENTS OF SPIRO(4.4)NONAPOLYENES. UNUSUALLY RAPID 1,5-VINYL MIGRATION Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/Chin.197714106 |
0.549 |
|
| 1977 |
Semmelhack MF, Weller HN, Foos JS. Thermal rearrangements of spiro[4.4]nonapolyenes. Unusually rapid 1,5-vinyl migration [34] Journal of the American Chemical Society. 99: 292-294. |
0.636 |
|
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