Martin J. Lohse
Affiliations: | 1993-2022 | Pharmacology | University of Würzburg, Würzburg, Bayern, Germany |
| 2016-2021 | Max Delbrück Center Berlin | ||
| 2020- | ISAR Bioscience Institute, Planegg/Munich |
Area:
Pharmacology; Receptors; Cell SignalingWebsite:
https://www.isarbioscience.de/en/team/prof-martin-lohse-md/Google:
"Martin Lohse"Bio:
Born in Mainz, Germany, August 26th, 1956
Studied medicine and philosophy at the universities of Göttingen, Germany, London, UK, and Paris, France.
State exam in medicine, Göttingen 1981; MD Göttingen 1981
Postdoc in pharmacology with Ulrich Schwabe, Bonn 1983, Heidelberg, Germany, 1983-1988
Research Associate and Assistant Professor with Robert J. Lefkowitz, Duke University 1988-1990
Group leader, Gene Center, Munich-Martinried, Germany, 1990-1993
Professor of Pharmacology, University of Würzburg, Germany, 1993-2022 (retired)
Chairman, Rudolf Virchow Center, University of Würzburg, 2001-2016
Director, Graduate Schools, University of Würzburg, 2003-2016
Vice President for Research, University of Würzburg, Germany, 2009-2015
Vice President, Leopoldina National Academy of Sciences, Germany, 2009-2019
Scientific Director and Chair of the Board of Directors Max Delbrück Center Berlin 2016-2019
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Mean distance: 12.82 (cluster 6) | S | N | B | C | P |
Parents
Sign in to add mentor| Otto D. Creutzfeldt | grad student | 1978-1980 | Max-Planck-Institut für biophysikalische Chemie |
| Ulrich Schwabe | post-doc | 1983-1988 | University of Heidelberg, Germany |
| Robert J. Lefkowitz | research scientist | 1988-1990 | Duke University / HHMI |
| Ernst-Ludwig Winnacker | research scientist | 1990-1993 | University of Munich, Germany |
Children
Sign in to add traineeCollaborators
Sign in to add collaborator| Michel Bouvier | collaborator | Université de Montréal | |
| Brian K. Kobilka | collaborator | Stanford | |
| Jean-Philippe Pin | collaborator | Institute de Genomique Fonctionelle |
Publications
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| Pan KS, Wang Z, Pfeil C, et al. (2025) Pharmacological characterization of a clinical candidate, TG-0054, a small molecule inverse agonist targeting CXCR4. Molecular Pharmacology. 107: 100015 |
| Sirbu A, Bathe-Peters M, Kumar JLM, et al. (2024) Cell swelling enhances ligand-driven β-adrenergic signaling. Nature Communications. 15: 7822 |
| Fasciani I, Petragnano F, Wang Z, et al. (2024) The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions. Plos Biology. 22: e3002582 |
| Aydin A, Klenk C, Nemec K, et al. (2024) ADAM19 cleaves the PTH receptor and associates with brachydactyly type E. Life Science Alliance. 7 |
| Lohse MJ, Bock A, Zaccolo M. (2023) G Protein-Coupled Receptor Signaling: New Insights Define Cellular Nanodomains. Annual Review of Pharmacology and Toxicology |
| Nemec K, Schihada H, Kleinau G, et al. (2022) Functional modulation of PTH1R activation and signaling by RAMP2. Proceedings of the National Academy of Sciences of the United States of America. 119: e2122037119 |
| Rodríguez-Soacha DA, Steinmüller SAM, Işbilir A, et al. (2022) Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CBR) "Cis-On" Agonist. Acs Chemical Neuroscience. 13: 2410-2435 |
| Anton SE, Kayser C, Maiellaro I, et al. (2022) Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell. 185: 1130-1142.e11 |
| Kayser C, Lohse MJ, Bock A. (2022) Real-Time Measurements of Intracellular cAMP Gradients Using FRET-Based cAMP Nanorulers. Methods in Molecular Biology (Clifton, N.J.). 2483: 1-13 |
| Klenk C, Hommers L, Lohse MJ. (2022) Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor. Frontiers in Endocrinology. 13: 839351 |