| Year |
Citation |
Score |
| 2024 |
Lizcano-Perret B, Vertommen D, Herinckx G, Calabrese V, Gatto L, Roux PP, Michiels T. Identification of RSK substrates using an analog-sensitive kinase approach. The Journal of Biological Chemistry. 105739. PMID 38342435 DOI: 10.1016/j.jbc.2024.105739 |
0.371 |
|
| 2022 |
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean É, Guérin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP. CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma. Nature Communications. 13: 6457. PMID 36309522 DOI: 10.1038/s41467-022-34179-8 |
0.788 |
|
| 2022 |
Vadnjal N, Nourreddine S, Lavoie G, Serres M, Roux PP, Paluch EK. Proteomic analysis of the actin cortex in interphase and mitosis. Journal of Cell Science. PMID 35892282 DOI: 10.1242/jcs.259993 |
0.753 |
|
| 2022 |
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb. Current Biology : Cb. 32: 733-734. PMID 35134350 DOI: 10.1016/j.cub.2022.01.027 |
0.505 |
|
| 2021 |
Cerezo EL, Houles T, Lié O, Sarthou MK, Audoynaud C, Lavoie G, Halladjian M, Cantaloube S, Froment C, Burlet-Schiltz O, Henry Y, Roux PP, Henras AK, Romeo Y. RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit. Plos Genetics. 17: e1009583. PMID 34125833 DOI: 10.1371/journal.pgen.1009583 |
0.351 |
|
| 2020 |
Méant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP. Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion. Molecular & Cellular Proteomics : McP. 19: 50-64. PMID 33451558 DOI: 10.1074/mcp.RA119.001811 |
0.456 |
|
| 2020 |
De Jamblinne CV, Decelle B, Dehghani M, Joseph M, Sriskandarajah N, Leguay K, Rambaud B, Lemieux S, Roux PP, Hipfner DR, Carréno S. STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity. The Journal of Cell Biology. 219. PMID 32960945 DOI: 10.1083/jcb.201911035 |
0.369 |
|
| 2020 |
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, ... ... Roux PP, et al. Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer. Nature Communications. 11: 3701. PMID 32709883 DOI: 10.1038/S41467-020-17549-Y |
0.753 |
|
| 2020 |
Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Méant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carreno S, Roux PP. NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. Cell Reports. 31: 107660. PMID 32433969 DOI: 10.1016/J.Celrep.2020.107660 |
0.754 |
|
| 2020 |
Berman AJ, Thoreen CC, Dedeic Z, Chettle J, Roux PP, Sarah BP. Controversies around the function of LARP1. Rna Biology. 1-11. PMID 32233986 DOI: 10.1080/15476286.2020.1733787 |
0.349 |
|
| 2020 |
Layoun A, Goldberg AA, Baig A, Eng M, Attias O, Nelson K, Carella A, Amberber N, Fielhaber JA, Joung KB, Schmeing TM, Han Y, Downey J, Divangahi M, Roux PP, et al. Publisher Correction: Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1. Scientific Reports. 10: 3337. PMID 32075988 DOI: 10.1038/S41598-020-58962-Z |
0.399 |
|
| 2020 |
Serres MP, Samwer M, Truong Quang BA, Lavoie G, Perera U, Görlich D, Charras G, Petronczki M, Roux PP, Paluch EK. F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis. Developmental Cell. PMID 31928973 DOI: 10.1016/J.Devcel.2019.12.011 |
0.338 |
|
| 2019 |
Layoun A, Goldberg AA, Baig A, Eng M, Attias O, Nelson K, Carella A, Amberber N, Fielhaber JA, Joung KB, Martin Schmeing T, Han Y, Downey J, Divangahi M, Roux PP, et al. Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1. Scientific Reports. 9: 17620. PMID 31772273 DOI: 10.1038/S41598-019-53909-5 |
0.474 |
|
| 2019 |
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, ... ... Roux PP, et al. Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities. Blood Advances. 3: 3307-3321. PMID 31698461 DOI: 10.1182/Bloodadvances.2019030981 |
0.313 |
|
| 2019 |
Meant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP. Proteomic analysis reveals a role for RSK in p120-catenin phosphorylation and melanoma cell-cell adhesion. Molecular & Cellular Proteomics : McP. PMID 31678930 DOI: 10.1074/Mcp.Ra119.001811 |
0.806 |
|
| 2019 |
Plutoni C, Keil S, Zeledon C, Delsin LEA, Decelle B, Roux PP, Carréno S, Emery G. Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration. Nature Communications. 10: 3940. PMID 31477736 DOI: 10.1038/S41467-019-11963-7 |
0.37 |
|
| 2019 |
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, ... ... Roux PP, et al. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia. Cancer Cell. 36: 84-99.e8. PMID 31287994 DOI: 10.1016/J.Ccell.2019.06.003 |
0.336 |
|
| 2019 |
de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, ... Roux PP, et al. Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children. Genes, Chromosomes & Cancer. PMID 31102422 DOI: 10.1002/Gcc.22765 |
0.335 |
|
| 2019 |
Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO. ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30728292 DOI: 10.1073/Pnas.1811923116 |
0.632 |
|
| 2019 |
Cao L, Yonis A, Vaghela M, Chugh P, Bohec P, Smith M, Lavoie G, Paluch EK, Roux P, Jegou AG, Charras G, Romet-Lemonne G. Nckipsd Coordinates Arp2/3 and Formin Nucleation of Actin Filaments in the Cell Cortex Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1379 |
0.303 |
|
| 2018 |
Roux PP, Topisirovic I. Signaling pathways involved in the regulation of mRNA translation. Molecular and Cellular Biology. PMID 29610153 DOI: 10.1128/Mcb.00070-18 |
0.467 |
|
| 2018 |
Ouadda ABD, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N. CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein. Oncotarget. 9: 11646-11664. PMID 29545927 DOI: 10.18632/Oncotarget.24126 |
0.458 |
|
| 2018 |
Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP. RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma. Cancer Research. PMID 29440170 DOI: 10.1158/0008-5472.Can-17-2215 |
0.438 |
|
| 2018 |
Baccelli I, Gareau Y, Lehnertz B, Stephane G, Spinella J, Beautrait A, Corneau S, Mayotte N, Boivin I, Girard S, MacRae T, Frechette M, Leveille K, Krosl J, Thiollier C, ... ... Roux PP, et al. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia Blood. 132: 910-910. DOI: 10.1182/Blood-2018-99-114525 |
0.382 |
|
| 2018 |
Chagraoui J, Tomellini E, Aubert L, Fares I, Spinella J, Girard S, Mayotte N, Roux PP, Sauvageau G. Coordination of Pro- and Anti-Inflammatory Signals Determine Human Hematopoietic Stem and Progenitor Cell Expansion Blood. 132: 2555-2555. DOI: 10.1182/Blood-2018-99-111917 |
0.329 |
|
| 2018 |
Bosoi CR, Daniel N, Bellmann K, Houde VP, Schwab M, Kumar A, Roux PP, Laplante M, Marette A. P90 Ribosomal S6 Kinase is a Potential Diabetes Therapeutic Target Canadian Journal of Diabetes. 42: S57. DOI: 10.1016/J.Jcjd.2018.08.174 |
0.32 |
|
| 2017 |
Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular Cell. PMID 28757207 DOI: 10.1016/J.Molcel.2017.06.033 |
0.663 |
|
| 2017 |
Chugh P, Clark AG, Smith MB, Cassani DAD, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch EK. Actin cortex architecture regulates cell surface tension. Nature Cell Biology. PMID 28530659 DOI: 10.1038/Ncb3525 |
0.347 |
|
| 2017 |
Houles T, Roux PP. Defining the role of the RSK isoforms in cancer. Seminars in Cancer Biology. PMID 28476656 DOI: 10.1016/J.Semcancer.2017.04.016 |
0.477 |
|
| 2017 |
Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G. EPCR expression marks UM171-expanded CD34(+) cord blood stem cells. Blood. PMID 28408459 DOI: 10.1182/Blood-2016-11-750729 |
0.307 |
|
| 2017 |
Zhang X, Lavoie G, Méant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP. ERK1/2 phosphorylate Gab2 to promote a negative feedback loop that attenuates PI3K/Akt signaling. Molecular and Cellular Biology. PMID 28096188 DOI: 10.1128/Mcb.00357-16 |
0.497 |
|
| 2016 |
Laflamme C, Galan JA, Ben El Kadhi K, Méant A, Zeledon C, Carréno S, Roux PP, Emery G. Proteomics screen identifies class I Rab11-FIPs as key regulators of cytokinesis. Molecular and Cellular Biology. PMID 27872148 DOI: 10.1128/Mcb.00278-16 |
0.384 |
|
| 2016 |
Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, ... ... Roux PP, et al. High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells. The Journal of Clinical Investigation. PMID 27797342 DOI: 10.1172/Jci86489 |
0.756 |
|
| 2016 |
Gerby B, Veiga DF, Krosl J, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox P, Chagraoui J, ... ... Roux PP, et al. Targeting Pre-Leukemic Stem Cells in T-Acute Lymphoblastic Leukemia Blood. 128: 527-527. DOI: 10.1182/Blood.V128.22.527.527 |
0.383 |
|
| 2015 |
Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M. Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression. Proceedings of the National Academy of Sciences of the United States of America. 112: E5160-8. PMID 26324936 DOI: 10.1073/Pnas.1508836112 |
0.413 |
|
| 2015 |
Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi R. Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice. Plos One. 10: e0119387. PMID 25803847 DOI: 10.1371/Journal.Pone.0119387 |
0.43 |
|
| 2015 |
Cargnello M, Tcherkezian J, Roux PP. The expanding role of mTOR in cancer cell growth and proliferation. Mutagenesis. 30: 169-76. PMID 25688110 DOI: 10.1093/Mutage/Geu045 |
0.47 |
|
| 2015 |
Gao B, Roux PP. Translational control by oncogenic signaling pathways. Biochimica Et Biophysica Acta. 1849: 753-765. PMID 25477072 DOI: 10.1016/J.Bbagrm.2014.11.006 |
0.459 |
|
| 2014 |
Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MG. A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells. Nature Communications. 5: 4431. PMID 25028204 DOI: 10.1038/Ncomms5431 |
0.435 |
|
| 2014 |
Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Roux PP, Paluch EK, et al. Cellular control of cortical actin nucleation. Current Biology : Cb. 24: 1628-35. PMID 25017211 DOI: 10.1016/J.Cub.2014.05.069 |
0.332 |
|
| 2014 |
Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP. Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proceedings of the National Academy of Sciences of the United States of America. 111: E2918-27. PMID 25002506 DOI: 10.1073/Pnas.1405601111 |
0.664 |
|
| 2014 |
Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi R. Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice. Molecular Reproduction and Development. 81: 655-65. PMID 24753052 DOI: 10.1002/Mrd.22333 |
0.503 |
|
| 2014 |
Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PP. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Genes & Development. 28: 357-71. PMID 24532714 DOI: 10.1101/Gad.231407.113 |
0.391 |
|
| 2014 |
Shin S, Wolgamott L, Roux PP, Yoon SO. Casein kinase 1ε promotes cell proliferation by regulating mRNA translation. Cancer Research. 74: 201-11. PMID 24247720 DOI: 10.1158/0008-5472.Can-13-1175 |
0.405 |
|
| 2014 |
Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SO. Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1. Oncogene. 33: 1690-9. PMID 23584478 DOI: 10.1038/Onc.2013.113 |
0.441 |
|
| 2013 |
Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch EK. Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging. Cytoskeleton (Hoboken, N.J.). 70: 741-54. PMID 24136886 DOI: 10.1002/Cm.21142 |
0.314 |
|
| 2013 |
Yoon SO, Roux PP. Rapamycin resistance: mTORC1 substrates hold some of the answers. Current Biology : Cb. 23: R880-3. PMID 24112984 DOI: 10.1016/J.Cub.2013.08.030 |
0.345 |
|
| 2013 |
Roux PP, Thibault P. The coming of age of phosphoproteomics--from large data sets to inference of protein functions. Molecular & Cellular Proteomics : McP. 12: 3453-64. PMID 24037665 DOI: 10.1074/Mcp.R113.032862 |
0.425 |
|
| 2013 |
Smadja-Lamère N, Shum M, Déléris P, Roux PP, Abe J, Marette A. Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism. The Journal of Biological Chemistry. 288: 31165-76. PMID 24036112 DOI: 10.1074/Jbc.M113.474148 |
0.361 |
|
| 2013 |
Wang P, Galan JA, Normandin K, Bonneil É, Hickson GR, Roux PP, Thibault P, Archambault V. Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression. The Journal of Cell Biology. 202: 277-93. PMID 23857770 DOI: 10.1083/Jcb.201211141 |
0.472 |
|
| 2013 |
Capo-Chichi JM, Tcherkezian J, Hamdan FF, Décarie JC, Dobrzeniecka S, Patry L, Nadon MA, Mucha BE, Major P, Shevell M, Bencheikh BO, Joober R, Samuels ME, Rouleau GA, Roux PP, et al. Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly. Journal of Medical Genetics. 50: 740-4. PMID 23687350 DOI: 10.1136/Jmedgenet-2013-101680 |
0.376 |
|
| 2013 |
Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PP. Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility. Molecular and Cellular Biology. 33: 1657-70. PMID 23401857 DOI: 10.1128/Mcb.01353-12 |
0.541 |
|
| 2013 |
Ray-David H, Romeo Y, Lavoie G, Déléris P, Tcherkezian J, Galan JA, Roux PP. RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance. Oncogene. 32: 4480-9. PMID 23108403 DOI: 10.1038/Onc.2012.472 |
0.434 |
|
| 2013 |
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KLB, Meloche S, Roux PP. RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth Oncogene. 32: 2917-2926. PMID 22797077 DOI: 10.1038/Onc.2012.312 |
0.517 |
|
| 2013 |
Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PP. Abstract 5191: Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility. Cancer Research. 73: 5191-5191. DOI: 10.1158/1538-7445.Am2013-5191 |
0.528 |
|
| 2012 |
Cargnello M, Tcherkezian J, Dorn JF, Huttlin EL, Maddox PS, Gygi SP, Roux PP. Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly. Molecular and Cellular Biology. 32: 4572-84. PMID 22966201 DOI: 10.1128/Mcb.00544-12 |
0.335 |
|
| 2012 |
Roux PP, Topisirovic I. Regulation of mRNA translation by signaling pathways. Cold Spring Harbor Perspectives in Biology. 4. PMID 22888049 DOI: 10.1101/Cshperspect.A012252 |
0.476 |
|
| 2012 |
Saha M, Carriere A, Cheerathodi M, Zhang X, Lavoie G, Rush J, Roux PP, Ballif BA. RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. The Biochemical Journal. 447: 159-66. PMID 22827337 DOI: 10.1042/Bj20120938 |
0.473 |
|
| 2012 |
Meloche S, Roux PP. F-box proteins elongate translation during stress recovery. Science Signaling. 5: pe25. PMID 22669843 DOI: 10.1126/Scisignal.2003163 |
0.415 |
|
| 2012 |
Fielhaber JA, Tan J, Joung KB, Attias O, Huegel S, Bader M, Roux PP, Kristof AS. Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin. The Journal of Biological Chemistry. 287: 14325-35. PMID 22399302 DOI: 10.1074/Jbc.M111.246785 |
0.433 |
|
| 2012 |
Romeo Y, Zhang X, Roux PP. Regulation and function of the RSK family of protein kinases. The Biochemical Journal. 441: 553-69. PMID 22187936 DOI: 10.1042/Bj20110289 |
0.467 |
|
| 2011 |
Caron E, Vincent K, Fortier MH, Laverdure JP, Bramoullé A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P, Perreault C. The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation. Molecular Systems Biology. 7: 533. PMID 21952136 DOI: 10.1038/Msb.2011.68 |
0.324 |
|
| 2011 |
Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiology and Molecular Biology Reviews : Mmbr. 75: 50-83. PMID 21372320 DOI: 10.1128/Mmbr.00031-10 |
0.495 |
|
| 2011 |
Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PP. ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). The Journal of Biological Chemistry. 286: 567-77. PMID 21071439 DOI: 10.1074/Jbc.M110.159046 |
0.499 |
|
| 2011 |
Romeo Y, Roux PP. Paving the way for targeting RSK in cancer. Expert Opinion On Therapeutic Targets. 15: 5-9. PMID 20958120 DOI: 10.1517/14728222.2010.531014 |
0.501 |
|
| 2010 |
Julien LA, Roux PP. [mTOR, the mammalian target of rapamycin]. MéDecine Sciences : M/S. 26: 1056-60. PMID 21187044 DOI: 10.1051/Medsci/201026121056 |
0.465 |
|
| 2010 |
Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano H. A comprehensive map of the mTOR signaling network. Molecular Systems Biology. 6: 453. PMID 21179025 DOI: 10.1038/Msb.2010.108 |
0.331 |
|
| 2010 |
Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. The Embo Journal. 29: 3939-51. PMID 21045808 DOI: 10.1038/Emboj.2010.271 |
0.43 |
|
| 2010 |
Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JG. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell. 141: 632-44. PMID 20434207 DOI: 10.1016/J.Cell.2010.04.008 |
0.403 |
|
| 2010 |
Julien LA, Carriere A, Moreau J, Roux PP. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Molecular and Cellular Biology. 30: 908-21. PMID 19995915 DOI: 10.1128/Mcb.00601-09 |
0.501 |
|
| 2010 |
Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. The Journal of Biological Chemistry. 285: 80-94. PMID 19864431 DOI: 10.1074/Jbc.M109.029637 |
0.447 |
|
| 2008 |
Stratford AL, Fry CJ, Desilets C, Davies AH, Cho YY, Li Y, Dong Z, Berquin IM, Roux PP, Dunn SE. Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells. Breast Cancer Research : Bcr. 10: R99. PMID 19036157 DOI: 10.1186/Bcr2202 |
0.478 |
|
| 2008 |
Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proceedings of the National Academy of Sciences of the United States of America. 105: 17414-9. PMID 18955708 DOI: 10.1073/Pnas.0809136105 |
0.605 |
|
| 2008 |
Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, Roux PP. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Current Biology : Cb. 18: 1269-77. PMID 18722121 DOI: 10.1016/J.Cub.2008.07.078 |
0.494 |
|
| 2008 |
Carriere A, Ray H, Blenis J, Roux PP. The RSK factors of activating the Ras/MAPK signaling cascade. Frontiers in Bioscience : a Journal and Virtual Library. 13: 4258-75. PMID 18508509 DOI: 10.2741/3003 |
0.683 |
|
| 2007 |
Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. The Journal of Biological Chemistry. 282: 14056-64. PMID 17360704 DOI: 10.1074/Jbc.M700906200 |
0.652 |
|
| 2007 |
Roux PP, Blenis J. MAPK signaling in human diseases Apoptosis, Cell Signaling, and Human Diseases. 2: 135-149. DOI: 10.1007/978-1-59745-199-4_6 |
0.471 |
|
| 2006 |
Choo AY, Roux PP, Blenis J. Mind the GAP: Wnt steps onto the mTORC1 train. Cell. 126: 834-6. PMID 16959561 DOI: 10.1016/J.Cell.2006.08.025 |
0.636 |
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| 2006 |
Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The Embo Journal. 25: 2781-91. PMID 16763566 DOI: 10.1038/Sj.Emboj.7601166 |
0.642 |
|
| 2005 |
Anjum R, Roux PP, Ballif BA, Gygi SP, Blenis J. The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Current Biology : Cb. 15: 1762-7. PMID 16213824 DOI: 10.1016/J.Cub.2005.08.050 |
0.687 |
|
| 2005 |
Ballif BA, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proceedings of the National Academy of Sciences of the United States of America. 102: 667-72. PMID 15647351 DOI: 10.1073/Pnas.0409143102 |
0.8 |
|
| 2004 |
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proceedings of the National Academy of Sciences of the United States of America. 101: 13489-94. PMID 15342917 DOI: 10.1073/Pnas.0405659101 |
0.653 |
|
| 2004 |
Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiology and Molecular Biology Reviews : Mmbr. 68: 320-44. PMID 15187187 DOI: 10.1128/Mmbr.68.2.320-344.2004 |
0.654 |
|
| 2004 |
Bouchard JF, Moore SW, Tritsch NX, Roux PP, Shekarabi M, Barker PA, Kennedy TE. Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3040-50. PMID 15044543 DOI: 10.1523/Jneurosci.4934-03.2004 |
0.735 |
|
| 2003 |
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current Biology : Cb. 13: 1259-68. PMID 12906785 DOI: 10.1016/S0960-9822(03)00506-2 |
0.57 |
|
| 2003 |
Roux PP, Richards SA, Blenis J. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Molecular and Cellular Biology. 23: 4796-804. PMID 12832467 DOI: 10.1128/Mcb.23.14.4796-4804.2003 |
0.665 |
|
| 2002 |
Roux PP, Dorval G, Boudreau M, Angers-Loustau A, Morris SJ, Makkerh J, Barker PA. K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. The Journal of Biological Chemistry. 277: 49473-80. PMID 12388555 DOI: 10.1074/Jbc.M203428200 |
0.597 |
|
| 2002 |
Roux PP, Barker PA. Neurotrophin signaling through the p75 neurotrophin receptor. Progress in Neurobiology. 67: 203-33. PMID 12169297 DOI: 10.1016/S0301-0082(02)00016-3 |
0.566 |
|
| 2001 |
Roux PP, Bhakar AL, Kennedy TE, Barker PA. The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. The Journal of Biological Chemistry. 276: 23097-104. PMID 11312266 DOI: 10.1074/Jbc.M011520200 |
0.729 |
|
| 2000 |
Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. Neuron. 27: 279-88. PMID 10985348 DOI: 10.1016/S0896-6273(00)00036-2 |
0.541 |
|
| 1999 |
Roux PP, Colicos MA, Barker PA, Kennedy TE. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6887-96. PMID 10436046 DOI: 10.1523/Jneurosci.19-16-06887.1999 |
0.751 |
|
| 1999 |
Bhakar AL, Roux PP, Lachance C, Kryl D, Zeindler C, Barker PA. The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress. The Journal of Biological Chemistry. 274: 21443-9. PMID 10409708 DOI: 10.1074/Jbc.274.30.21443 |
0.527 |
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