Philippe P. Roux, Ph.D. - Publications

Affiliations: 
1997-2002 Neurology and Neurosurgery McGill (Montreal Neurological Institute) 

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO. ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30728292 DOI: 10.1073/pnas.1811923116  1
2018 Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP. RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma. Cancer Research. PMID 29440170 DOI: 10.1158/0008-5472.CAN-17-2215  0.32
2017 Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular Cell. PMID 28757207 DOI: 10.1016/j.molcel.2017.06.033  1
2015 Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M. Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression. Proceedings of the National Academy of Sciences of the United States of America. 112: E5160-8. PMID 26324936 DOI: 10.1073/pnas.1508836112  1
2015 Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi R. Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice. Plos One. 10: e0119387. PMID 25803847 DOI: 10.1371/journal.pone.0119387  1
2015 Cargnello M, Tcherkezian J, Roux PP. The expanding role of mTOR in cancer cell growth and proliferation. Mutagenesis. 30: 169-76. PMID 25688110 DOI: 10.1093/mutage/geu045  1
2015 Gao B, Roux PP. Translational control by oncogenic signaling pathways. Biochimica Et Biophysica Acta. 1849: 753-765. PMID 25477072 DOI: 10.1016/j.bbagrm.2014.11.006  1
2014 Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MG. A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells. Nature Communications. 5: 4431. PMID 25028204 DOI: 10.1038/ncomms5431  1
2014 Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Roux PP, Paluch EK, et al. Cellular control of cortical actin nucleation. Current Biology : Cb. 24: 1628-35. PMID 25017211 DOI: 10.1016/j.cub.2014.05.069  1
2014 Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP. Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proceedings of the National Academy of Sciences of the United States of America. 111: E2918-27. PMID 25002506 DOI: 10.1073/pnas.1405601111  1
2014 Perrault I, Hamdan FF, Rio M, Capo-Chichi JM, Boddaert N, Décarie JC, Maranda B, Nabbout R, Sylvain M, Lortie A, Roux PP, Rossignol E, Gérard X, Barcia G, Berquin P, et al. Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness. American Journal of Human Genetics. 94: 891-7. PMID 24814191 DOI: 10.1016/j.ajhg.2014.04.012  1
2014 Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi R. Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice. Molecular Reproduction and Development. 81: 655-65. PMID 24753052 DOI: 10.1002/mrd.22333  1
2014 Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PP. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Genes & Development. 28: 357-71. PMID 24532714 DOI: 10.1101/gad.231407.113  1
2014 Shin S, Wolgamott L, Roux PP, Yoon SO. Casein kinase 1ε promotes cell proliferation by regulating mRNA translation. Cancer Research. 74: 201-11. PMID 24247720 DOI: 10.1158/0008-5472.CAN-13-1175  1
2014 Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SO. Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1. Oncogene. 33: 1690-9. PMID 23584478 DOI: 10.1038/onc.2013.113  1
2013 Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch EK. Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging. Cytoskeleton (Hoboken, N.J.). 70: 741-54. PMID 24136886 DOI: 10.1002/cm.21142  1
2013 Yoon SO, Roux PP. Rapamycin resistance: mTORC1 substrates hold some of the answers. Current Biology : Cb. 23: R880-3. PMID 24112984 DOI: 10.1016/j.cub.2013.08.030  1
2013 Roux PP, Thibault P. The coming of age of phosphoproteomics--from large data sets to inference of protein functions. Molecular & Cellular Proteomics : McP. 12: 3453-64. PMID 24037665 DOI: 10.1074/mcp.R113.032862  1
2013 Smadja-Lamère N, Shum M, Déléris P, Roux PP, Abe J, Marette A. Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism. The Journal of Biological Chemistry. 288: 31165-76. PMID 24036112 DOI: 10.1074/jbc.M113.474148  1
2013 Wang P, Galan JA, Normandin K, Bonneil É, Hickson GR, Roux PP, Thibault P, Archambault V. Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression. The Journal of Cell Biology. 202: 277-93. PMID 23857770 DOI: 10.1083/jcb.201211141  1
2013 Capo-Chichi JM, Tcherkezian J, Hamdan FF, Décarie JC, Dobrzeniecka S, Patry L, Nadon MA, Mucha BE, Major P, Shevell M, Bencheikh BO, Joober R, Samuels ME, Rouleau GA, Roux PP, et al. Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly. Journal of Medical Genetics. 50: 740-4. PMID 23687350 DOI: 10.1136/jmedgenet-2013-101680  1
2013 Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PP. Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility. Molecular and Cellular Biology. 33: 1657-70. PMID 23401857 DOI: 10.1128/MCB.01353-12  1
2013 Ray-David H, Romeo Y, Lavoie G, Déléris P, Tcherkezian J, Galan JA, Roux PP. RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance. Oncogene. 32: 4480-9. PMID 23108403 DOI: 10.1038/onc.2012.472  1
2013 Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KLB, Meloche S, Roux PP. RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth Oncogene. 32: 2917-2926. PMID 22797077 DOI: 10.1038/onc.2012.312  1
2012 Cargnello M, Tcherkezian J, Dorn JF, Huttlin EL, Maddox PS, Gygi SP, Roux PP. Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly. Molecular and Cellular Biology. 32: 4572-84. PMID 22966201 DOI: 10.1128/MCB.00544-12  1
2012 Roux PP, Topisirovic I. Regulation of mRNA translation by signaling pathways. Cold Spring Harbor Perspectives in Biology. 4. PMID 22888049 DOI: 10.1101/cshperspect.a012252  1
2012 Saha M, Carriere A, Cheerathodi M, Zhang X, Lavoie G, Rush J, Roux PP, Ballif BA. RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. The Biochemical Journal. 447: 159-66. PMID 22827337 DOI: 10.1042/BJ20120938  1
2012 Meloche S, Roux PP. F-box proteins elongate translation during stress recovery. Science Signaling. 5: pe25. PMID 22669843 DOI: 10.1126/scisignal.2003163  1
2012 Fielhaber JA, Tan J, Joung KB, Attias O, Huegel S, Bader M, Roux PP, Kristof AS. Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin. The Journal of Biological Chemistry. 287: 14325-35. PMID 22399302 DOI: 10.1074/jbc.M111.246785  1
2012 Romeo Y, Zhang X, Roux PP. Regulation and function of the RSK family of protein kinases. The Biochemical Journal. 441: 553-69. PMID 22187936 DOI: 10.1042/BJ20110289  1
2012 Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases (Microbiology and Molecular Biology Reviews (2011) 75, 1, (50-83)) Microbiology and Molecular Biology Reviews. 76: 496. DOI: 10.1128/MMBR.00013-12  1
2011 Caron E, Vincent K, Fortier MH, Laverdure JP, Bramoullé A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P, Perreault C. The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation. Molecular Systems Biology. 7: 533. PMID 21952136 DOI: 10.1038/msb.2011.68  1
2011 Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiology and Molecular Biology Reviews : Mmbr. 75: 50-83. PMID 21372320 DOI: 10.1128/MMBR.00031-10  1
2011 Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PP. ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). The Journal of Biological Chemistry. 286: 567-77. PMID 21071439 DOI: 10.1074/jbc.M110.159046  1
2011 Romeo Y, Roux PP. Paving the way for targeting RSK in cancer. Expert Opinion On Therapeutic Targets. 15: 5-9. PMID 20958120 DOI: 10.1517/14728222.2010.531014  1
2010 Julien LA, Roux PP. [mTOR, the mammalian target of rapamycin]. MéDecine Sciences : M/S. 26: 1056-60. PMID 21187044 DOI: 10.1051/medsci/201026121056  1
2010 Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano H. A comprehensive map of the mTOR signaling network. Molecular Systems Biology. 6: 453. PMID 21179025 DOI: 10.1038/msb.2010.108  1
2010 Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. The Embo Journal. 29: 3939-51. PMID 21045808 DOI: 10.1038/emboj.2010.271  1
2010 Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JG. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell. 141: 632-44. PMID 20434207 DOI: 10.1016/j.cell.2010.04.008  1
2010 Julien LA, Carriere A, Moreau J, Roux PP. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Molecular and Cellular Biology. 30: 908-21. PMID 19995915 DOI: 10.1128/MCB.00601-09  1
2010 Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. The Journal of Biological Chemistry. 285: 80-94. PMID 19864431 DOI: 10.1074/jbc.M109.029637  1
2008 Stratford AL, Fry CJ, Desilets C, Davies AH, Cho YY, Li Y, Dong Z, Berquin IM, Roux PP, Dunn SE. Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells. Breast Cancer Research : Bcr. 10: R99. PMID 19036157 DOI: 10.1186/bcr2202  1
2008 Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proceedings of the National Academy of Sciences of the United States of America. 105: 17414-9. PMID 18955708 DOI: 10.1073/pnas.0809136105  1
2008 Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, Roux PP. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Current Biology : Cb. 18: 1269-77. PMID 18722121 DOI: 10.1016/j.cub.2008.07.078  1
2008 Carriere A, Ray H, Blenis J, Roux PP. The RSK factors of activating the Ras/MAPK signaling cascade. Frontiers in Bioscience : a Journal and Virtual Library. 13: 4258-75. PMID 18508509 DOI: 10.2741/3003  1
2007 Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. The Journal of Biological Chemistry. 282: 14056-64. PMID 17360704 DOI: 10.1074/jbc.M700906200  1
2007 Roux PP, Blenis J. MAPK signaling in human diseases Apoptosis, Cell Signaling, and Human Diseases. 2: 135-149. DOI: 10.1007/978-1-59745-199-4_6  1
2006 Choo AY, Roux PP, Blenis J. Mind the GAP: Wnt steps onto the mTORC1 train. Cell. 126: 834-6. PMID 16959561 DOI: 10.1016/j.cell.2006.08.025  1
2006 Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The Embo Journal. 25: 2781-91. PMID 16763566 DOI: 10.1038/sj.emboj.7601166  1
2005 Anjum R, Roux PP, Ballif BA, Gygi SP, Blenis J. The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Current Biology : Cb. 15: 1762-7. PMID 16213824 DOI: 10.1016/j.cub.2005.08.050  1
2005 Ballif BA, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proceedings of the National Academy of Sciences of the United States of America. 102: 667-72. PMID 15647351 DOI: 10.1073/pnas.0409143102  1
2004 Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proceedings of the National Academy of Sciences of the United States of America. 101: 13489-94. PMID 15342917 DOI: 10.1073/pnas.0405659101  1
2004 Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiology and Molecular Biology Reviews : Mmbr. 68: 320-44. PMID 15187187 DOI: 10.1128/MMBR.68.2.320-344.2004  1
2004 Bouchard JF, Moore SW, Tritsch NX, Roux PP, Shekarabi M, Barker PA, Kennedy TE. Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3040-50. PMID 15044543 DOI: 10.1523/JNEUROSCI.4934-03.2004  1
2003 Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current Biology : Cb. 13: 1259-68. PMID 12906785 DOI: 10.1016/S0960-9822(03)00506-2  1
2003 Roux PP, Richards SA, Blenis J. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Molecular and Cellular Biology. 23: 4796-804. PMID 12832467 DOI: 10.1128/MCB.23.14.4796-4804.2003  1
2002 Roux PP, Dorval G, Boudreau M, Angers-Loustau A, Morris SJ, Makkerh J, Barker PA. K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. The Journal of Biological Chemistry. 277: 49473-80. PMID 12388555 DOI: 10.1074/jbc.M203428200  1
2002 Roux PP, Barker PA. Neurotrophin signaling through the p75 neurotrophin receptor. Progress in Neurobiology. 67: 203-33. PMID 12169297 DOI: 10.1016/S0301-0082(02)00016-3  1
2001 Roux PP, Bhakar AL, Kennedy TE, Barker PA. The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. The Journal of Biological Chemistry. 276: 23097-104. PMID 11312266 DOI: 10.1074/jbc.M011520200  1
2000 Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. Neuron. 27: 279-88. PMID 10985348  1
2000 Roux P, Alfieri C, Hrimech M, Cohen EA, Tanner JE. Activation of transcription factors NF-κB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression Journal of Virology. 74: 4658-4665. PMID 10775602 DOI: 10.1128/JVI.74.10.4658-4665.2000  1
1999 Roux PP, Colicos MA, Barker PA, Kennedy TE. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6887-96. PMID 10436046  1
1999 Bhakar AL, Roux PP, Lachance C, Kryl D, Zeindler C, Barker PA. The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress. The Journal of Biological Chemistry. 274: 21443-9. PMID 10409708 DOI: 10.1074/jbc.274.30.21443  1
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