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Nahum Sonenberg, PhD - Publications

Affiliations: 
Biochemistry McGill University, Montreal, QC, Canada 
Area:
translational control
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Year Citation  Score
2024 Huang Z, Wiebe S, Nagpal A, Choi J, Walters C, Mahmood N, Khoutorsky A, Lacaille JC, Sonenberg N. Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory. Learning & Memory (Cold Spring Harbor, N.Y.). 31. PMID 39467641 DOI: 10.1101/lm.054018.124  0.815
2024 Wang P, Li Z, Kim SH, Xu H, Huang H, Yang C, Snape A, Choi JH, Bermudez S, Boivin MN, Ferry N, Karamchandani J, Nagar B, Sonenberg N. PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation. Life Science Alliance. 7. PMID 39111820 DOI: 10.26508/lsa.202402755  0.438
2024 Mahmood N, Choi JH, Wu PY, Dooling SW, Watkins TA, Huang Z, Lipman J, Zhao H, Yang A, Silversmith J, Inglebert Y, Koumenis C, Sharma V, Lacaille JC, Sossin WS, ... ... Sonenberg N, et al. The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner. Proceedings of the National Academy of Sciences of the United States of America. 121: e2407472121. PMID 39047038 DOI: 10.1073/pnas.2407472121  0.621
2024 Choi JH, Luo J, Hesketh GG, Guo S, Pistofidis A, Ladak RJ, An Y, Naeli P, Alain T, Schmeing TM, Gingras AC, Duchaine T, Zhang X, Sonenberg N, Jafarnejad SM. Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction. Science Advances. 10: eadl5638. PMID 39018414 DOI: 10.1126/sciadv.adl5638  0.581
2024 Lister KC, Wong C, Uttam S, Parisien M, Stecum P, Brown N, Cai W, Hooshmandi M, Gu N, Amiri M, Beaudry F, Jafarnejad SM, Tavares-Ferreira D, Inturi NN, Mazhar K, ... ... Sonenberg N, et al. Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain. Biorxiv : the Preprint Server For Biology. PMID 38979173 DOI: 10.1101/2024.06.24.600539  0.752
2024 Cagnetta R, Lacaille JC, Sonenberg N. Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation. Molecular Brain. 17: 35. PMID 38858726 DOI: 10.1186/s13041-024-01100-x  0.779
2023 Sharma V, Oliveira MM, Sood R, Khlaifia A, Lou D, Hooshmandi M, Hung TY, Mahmood N, Reeves M, Ho-Tieng D, Cohen N, Cheng PC, Rahim MMA, Prager-Khoutorsky M, Kaufman RJ, ... ... Sonenberg N, et al. mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory. Proceedings of the National Academy of Sciences of the United States of America. 120: e2308671120. PMID 38015848 DOI: 10.1073/pnas.2308671120  0.632
2023 Pugsley L, Naineni SK, Amiri M, Yanagiya A, Cencic R, Sonenberg N, Pelletier J. C8ORF88: A Novel eIF4E-Binding Protein. Genes. 14. PMID 38003019 DOI: 10.3390/genes14112076  0.378
2023 Wong C, Tavares-Ferreira D, Thörn Perez C, Sharif B, Uttam S, Amiri M, Lister KC, Hooshmandi M, Nguyen V, Séguéla P, Sonenberg N, Price TJ, Gkogkas CG, Khoutorsky A. 4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling. Science Advances. 9: eadh9603. PMID 37922363 DOI: 10.1126/sciadv.adh9603  0.8
2023 Cagnetta R, Flanagan JG, Sonenberg N. Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 43: 7247-7263. PMID 37914402 DOI: 10.1523/JNEUROSCI.2240-22.2023  0.804
2023 Evans JF, McCormack FX, Sonenberg N, Krymskaya VP. Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis. European Respiratory Review : An Official Journal of the European Respiratory Society. 32. PMID 37758276 DOI: 10.1183/16000617.0100-2023  0.351
2023 Hooshmandi M, Sharma V, Thörn Perez C, Sood R, Krimbacher K, Wong C, Lister KC, Ureña Guzmán A, Bartley TD, Rocha C, Maussion G, Nadler E, Roque PM, Gantois I, Popic J, ... ... Sonenberg N, et al. Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome. Neuron. PMID 37473758 DOI: 10.1016/j.neuron.2023.06.017  0.778
2023 Kim SH, Choi JH, Marsal-García L, Amiri M, Yanagiya A, Sonenberg N. The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory. Proceedings of the National Academy of Sciences of the United States of America. 120: e2300008120. PMID 37307456 DOI: 10.1073/pnas.2300008120  0.309
2023 Stehn JR, Floyd SR, Wilker EW, Reinhardt HC, Clarke SM, Huang Q, Polakiewicz RD, Sonenberg N, Kong YW, Yaffe MB. MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach. Frontiers in Molecular Biosciences. 10: 1148933. PMID 37091863 DOI: 10.3389/fmolb.2023.1148933  0.304
2023 Wiebe S, Huang Z, Ladak RJ, Skalecka A, Cagnetta R, Lacaille JC, Aguilar-Valles A, Sonenberg N. Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP. Molecular Brain. 16: 9. PMID 36650535 DOI: 10.1186/s13041-023-00995-2  0.794
2022 Sonenberg N, Filipowicz W. Recollections - Dr. Yasuhiro Furuichi. Rna (New York, N.Y.). PMID 36617660 DOI: 10.1261/rna.079517.122  0.417
2022 Escós A, Martín-Gómez J, González-Romero D, Díaz-Mora E, Francisco-Velilla R, Santiago C, Cuezva JM, Domínguez-Zorita S, Martínez-Salas E, Sonenberg N, Sanz-Ezquerro JJ, Jafarnejad SM, Cuenda A. TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with mRNA. Proceedings of the National Academy of Sciences of the United States of America. 119: e2204752119. PMID 35994673 DOI: 10.1073/pnas.2204752119  0.369
2022 Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C, Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW, Giguère V, Oliveira RL, Constante M, ... ... Sonenberg N, et al. The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages. Proceedings of the National Academy of Sciences of the United States of America. 119: e2121251119. PMID 35994670 DOI: 10.1073/pnas.2121251119  0.625
2022 Xu Z, Choi JH, Dai DL, Luo J, Ladak RJ, Li Q, Wang Y, Zhang C, Wiebe S, Liu ACH, Ran X, Yang J, Naeli P, Garzia A, Zhou L, ... ... Sonenberg N, et al. SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation. Proceedings of the National Academy of Sciences of the United States of America. 119: e2204539119. PMID 35878012 DOI: 10.1073/pnas.2204539119  0.792
2021 Svitkin YV, Gingras AC, Sonenberg N. Membrane-dependent relief of translation elongation arrest on pseudouridine- and N1-methyl-pseudouridine-modified mRNAs. Nucleic Acids Research. PMID 34933339 DOI: 10.1093/nar/gkab1241  0.53
2021 Githaka JM, Tripathi N, Kirschenman R, Patel N, Pandya V, Kramer DA, Montpetit R, Zhu LF, Sonenberg N, Fahlman RP, Danial NN, Underhill DA, Goping IS. BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models. Nature Communications. 12: 2939. PMID 34011960 DOI: 10.1038/s41467-021-23269-8  0.33
2021 Hooshmandi M, Truong VT, Fields E, Thomas RE, Wong C, Sharma V, Gantois I, Soriano Roque P, Chalkiadaki K, Wu N, Chakraborty A, Tahmasebi S, Prager-Khoutorsky M, Sonenberg N, Suvrathan A, et al. 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. Cell Reports. 35: 109036. PMID 33910008 DOI: 10.1016/j.celrep.2021.109036  0.781
2021 Sharma V, Sood R, Lou D, Hung TY, Lévesque M, Han Y, Levett JY, Wang P, Murthy S, Tansley S, Wang S, Siddiqui N, Tahmasebi S, Rosenblum K, Avoli M, ... ... Sonenberg N, et al. 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33876772 DOI: 10.1073/pnas.2025522118  0.655
2021 Zhang X, Chapat C, Wang P, Choi JH, Li Q, Luo J, Wiebe S, Kim SH, Robichaud N, Karam IF, Dai D, Hackett AP, Lin R, Alain T, Yang L, ... ... Sonenberg N, et al. microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP. Molecular Cell. PMID 33581076 DOI: 10.1016/j.molcel.2021.01.030  0.568
2020 Kim SH, Choi JH, Wang P, Go CD, Hesketh GG, Gingras AC, Jafarnejad SM, Sonenberg N. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation. Molecular Cell. PMID 33340489 DOI: 10.1016/j.molcel.2020.11.036  0.443
2020 Pelletier J, Schmeing TM, Sonenberg N. The multifaceted eukaryotic cap structure. Wiley Interdisciplinary Reviews. Rna. e1636. PMID 33300197 DOI: 10.1002/wrna.1636  0.339
2020 Hernández G, García A, Sonenberg N, Lasko P. Unorthodox Mechanisms to Initiate Translation Open Novel Paths for Gene Expression. Journal of Molecular Biology. PMID 33166539 DOI: 10.1016/j.jmb.2020.10.035  0.378
2020 Sharma V, Sood R, Khlaifia A, Eslamizade MJ, Hung TY, Lou D, Asgarihafshejani A, Lalzar M, Kiniry SJ, Stokes MP, Cohen N, Nelson AJ, Abell K, Possemato AP, Gal-Ben-Ari S, ... ... Sonenberg N, et al. eIF2α controls memory consolidation via excitatory and somatostatin neurons. Nature. PMID 33029011 DOI: 10.1038/s41586-020-2805-8  0.638
2020 Steinberger J, Shen L, J Kiniry S, Naineni SK, Cencic R, Amiri M, Aboushawareb SAE, Chu J, Maïga RI, Yachnin BJ, Robert F, Sonenberg N, Baranov PV, Pelletier J. Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions. Nucleic Acids Research. PMID 32766783 DOI: 10.1093/Nar/Gkaa662  0.476
2020 Zu T, Guo S, Bardhi O, Ryskamp DA, Li J, Khoramian Tusi S, Engelbrecht A, Klippel K, Chakrabarty P, Nguyen L, Golde TE, Sonenberg N, Ranum LPW. Metformin inhibits RAN translation through PKR pathway and mitigates disease in ALS/FTD mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690681 DOI: 10.1073/Pnas.2005748117  0.414
2020 Dawson JE, Bah A, Zhang Z, Vernon RM, Lin H, Chong PA, Vanama M, Sonenberg N, Gradinaru CC, Forman-Kay JD. Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition. Nature Communications. 11: 3146. PMID 32561718 DOI: 10.1038/S41467-020-16783-8  0.424
2020 Wiebe S, Nagpal A, Sonenberg N. Dysregulated translational control in brain disorders: from genes to behavior. Current Opinion in Genetics & Development. 65: 34-41. PMID 32535350 DOI: 10.1016/J.Gde.2020.05.005  0.74
2020 Atlasi Y, Jafarnejad SM, Gkogkas CG, Vermeulen M, Sonenberg N, Stunnenberg HG. The translational landscape of ground state pluripotency. Nature Communications. 11: 1617. PMID 32238817 DOI: 10.1038/S41467-020-15449-9  0.727
2020 Pearl D, Katsumura S, Amiri M, Tabatabaei N, Zhang X, Vinette V, Pang X, Beug ST, Kim SH, Jones LM, Robichaud N, Ong SG, Jia JJ, Ali H, Tremblay ML, ... ... Sonenberg N, et al. 4E-BP-Dependent Translational Control of Mediates Adipose Tissue Macrophage Inflammatory Response. Journal of Immunology (Baltimore, Md. : 1950). PMID 32213561 DOI: 10.4049/Jimmunol.1900538  0.356
2020 Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, Sharma E, Quesnel-Vallières M, Permanyer J, Maier S, ... ... Sonenberg N, et al. Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions. Molecular Cell. PMID 31999954 DOI: 10.1016/J.Molcel.2020.01.006  0.552
2020 Muendlein HI, Sarhan J, Liu BC, Connolly WM, Schworer SA, Smirnova I, Tang AY, Ilyukha V, Pietruska J, Tahmasebi S, Sonenberg N, Degterev A, Poltorak A. Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation. Cell Reports. 30: 699-713.e4. PMID 31968247 DOI: 10.1016/J.Celrep.2019.12.073  0.382
2019 Starr CR, Nyankerh CNA, Qi X, Hu Y, Gorbatyuk OS, Sonenberg N, Boulton ME, Gorbatyuk MS. Role of Translational Attenuation in Inherited Retinal Degeneration. Investigative Ophthalmology & Visual Science. 60: 4849-4857. PMID 31747684 DOI: 10.1167/Iovs.19-27512  0.327
2019 Müller D, Shin S, Goullet de Rugy T, Samain R, Baer R, Strehaiano M, Masvidal-Sanz L, Guillermet-Guibert J, Jean C, Tsukumo Y, Sonenberg N, Marion F, Guilbaud N, Hoffmann JS, Larsson O, et al. eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer. Jci Insight. 4. PMID 31672935 DOI: 10.1172/Jci.Insight.121951  0.4
2019 Areal CC, Cao R, Sonenberg N, Mongrain V. Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2. Sleep. PMID 31553042 DOI: 10.1093/Sleep/Zsz210  0.471
2019 Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R. The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. Neuron. PMID 31522764 DOI: 10.1016/J.Neuron.2019.08.007  0.81
2019 Mohammad AH, Assadian S, Couture F, Lefebvre KJ, El-Assaad W, Barrès V, Ouellet V, Boulay PL, Yang J, Latour M, Furic L, Muller W, Sonenberg N, Mes-Masson AM, Saad F, et al. V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. Oncotarget. 10: 4923-4936. PMID 31452834 DOI: 10.18632/Oncotarget.27075  0.301
2019 Kim TH, Tsang B, Vernon RM, Sonenberg N, Kay LE, Forman-Kay JD. Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation. Science (New York, N.Y.). 365: 825-829. PMID 31439799 DOI: 10.1126/Science.Aax4240  0.366
2019 Wiebe S, Nagpal A, Truong VT, Park J, Skalecka A, He AJ, Gamache K, Khoutorsky A, Gantois I, Sonenberg N. Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2. Proceedings of the National Academy of Sciences of the United States of America. PMID 31427534 DOI: 10.1073/Pnas.1908126116  0.794
2019 Pelletier J, Sonenberg N. The Organizing Principles of Eukaryotic Ribosome Recruitment. Annual Review of Biochemistry. 88: 307-335. PMID 31220979 DOI: 10.1146/Annurev-Biochem-013118-111042  0.437
2019 Le Bacquer O, Combe K, Patrac V, Ingram B, Combaret L, Dardevet D, Montaurier C, Salles J, Giraudet C, Guillet C, Sonenberg N, Boirie Y, Walrand S. 4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia. Journal of Cachexia, Sarcopenia and Muscle. PMID 30927336 DOI: 10.1002/Jcsm.12412  0.346
2019 Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, ... ... Sonenberg N, et al. Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30926667 DOI: 10.1073/Pnas.1816023116  0.3
2019 Jeong SJ, Park S, Nguyen LT, Hwang J, Lee EY, Giong HK, Lee JS, Yoon I, Lee JH, Kim JH, Kim HK, Kim D, Yang WS, Kim SY, Lee CY, ... ... Sonenberg N, et al. A threonyl-tRNA synthetase-mediated translation initiation machinery. Nature Communications. 10: 1357. PMID 30902983 DOI: 10.1038/S41467-019-09086-0  0.461
2019 Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, ... Sonenberg N, et al. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Research. PMID 30894372 DOI: 10.1158/0008-5472.Can-18-1220  0.368
2019 Tsang B, Arsenault J, Vernon RM, Lin H, Sonenberg N, Wang LY, Bah A, Forman-Kay JD. Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30765518 DOI: 10.1073/Pnas.1814385116  0.436
2019 Sonenberg N. Decision letter: An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning Elife. DOI: 10.7554/Elife.48246.Sa1  0.364
2018 Tahmasebi S, Amiri M, Sonenberg N. Translational Control in Stem Cells. Frontiers in Genetics. 9: 709. PMID 30697227 DOI: 10.3389/Fgene.2018.00709  0.361
2018 Machida K, Shigeta T, Yamamoto Y, Ito T, Svitkin Y, Sonenberg N, Imataka H. Dynamic interaction of poly(A)-binding protein with the ribosome. Scientific Reports. 8: 17435. PMID 30487538 DOI: 10.1038/S41598-018-35753-1  0.468
2018 Megat S, Ray PR, Moy JK, Lou TF, Barragan-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, et al. Nociceptor translational profiling reveals the Ragulator-Rag GTPase complex as a critical generator of neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30459229 DOI: 10.1523/Jneurosci.2661-18.2018  0.686
2018 Ratcliffe CDH, Siddiqui N, Coelho PP, Laterreur N, Cookey TN, Sonenberg N, Park M. HGF-induced migration depends on the PI(3,4,5)P-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1. The Journal of Cell Biology. PMID 30404949 DOI: 10.1083/Jcb.201804106  0.345
2018 Cerezo M, Guemiri R, Druillennec S, Girault I, Malka-Mahieu H, Shen S, Allard D, Martineau S, Welsch C, Agoussi S, Estrada C, Adam J, Libenciuc C, Routier E, Roy S, ... ... Sonenberg N, et al. Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma. Nature Medicine. PMID 30374200 DOI: 10.1038/S41591-018-0217-1  0.311
2018 Gantois I, Popic J, Khoutorsky A, Sonenberg N. Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders. Annual Review of Medicine. PMID 30365357 DOI: 10.1146/Annurev-Med-081117-041238  0.616
2018 Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, ... ... Sonenberg N, et al. Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. Plos Pathogens. 14: e1007264. PMID 30138450 DOI: 10.1371/Journal.Ppat.1007264  0.375
2018 Tahmasebi S, Sonenberg N, Hershey JWB, Mathews MB. Protein Synthesis and Translational Control: A Historical Perspective. Cold Spring Harbor Perspectives in Biology. PMID 30082466 DOI: 10.1101/Cshperspect.A035584  0.367
2018 Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N. Translation deregulation in human disease. Nature Reviews. Molecular Cell Biology. PMID 30038383 DOI: 10.1038/S41580-018-0034-X  0.687
2018 Hershey JWB, Sonenberg N, Mathews MB. Principles of Translational Control. Cold Spring Harbor Perspectives in Biology. PMID 29959195 DOI: 10.1101/Cshperspect.A032607  0.456
2018 Robichaud N, Sonenberg N, Ruggero D, Schneider RJ. Translational Control in Cancer. Cold Spring Harbor Perspectives in Biology. PMID 29959193 DOI: 10.1101/Cshperspect.A032896  0.37
2018 Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, ... ... Sonenberg N, et al. Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nature Communications. 9: 2459. PMID 29941989 DOI: 10.1038/S41467-018-04883-5  0.525
2018 Moon SL, Sonenberg N, Parker R. Neuronal Regulation of eIF2α Function in Health and Neurological Disorders. Trends in Molecular Medicine. PMID 29716790 DOI: 10.1016/J.Molmed.2018.04.001  0.36
2018 Chong Y, Saviuk N, Pie B, Basisty N, Quinn RK, Schilling B, Sonenberg N, Cooper E, Haghighi AP. Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity. Cell Reports. 23: 11-22. PMID 29617653 DOI: 10.1016/J.Celrep.2018.03.040  0.31
2018 Liu D, Stowie A, de Zavalia N, Leise T, Pathak SS, Drewes LR, Davidson AJ, Amir S, Sonenberg N, Cao R. mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction. Proceedings of the National Academy of Sciences of the United States of America. PMID 29555746 DOI: 10.1073/Pnas.1721578115  0.781
2018 Ramon Y Cajal S, Castellvi J, Hümmer S, Peg V, Pelletier J, Sonenberg N. Beyond molecular tumor heterogeneity: protein synthesis takes control. Oncogene. PMID 29463861 DOI: 10.1038/S41388-018-0152-0  0.304
2018 Robichaud N, Hsu BE, Istomine R, Alvarez F, Blagih J, Ma EH, Morales SV, Dai DL, Li G, Souleimanova M, Guo Q, Del Rincon SV, Miller WH, Ramón Y Cajal S, Park M, ... ... Sonenberg N, et al. Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463754 DOI: 10.1073/Pnas.1717439115  0.646
2018 Ding M, van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP, Koritzinsky M, Wouters BG. The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer. Molecular Cancer Research : McR. PMID 29453322 DOI: 10.1158/1541-7786.Mcr-17-0696  0.386
2018 Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas C, Stern-Ginossar N, ... ... Sonenberg N, et al. Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife. 7. PMID 29412140 DOI: 10.7554/Elife.35034  0.8
2018 Ruan H, Li X, Leibowitz B, Tong J, Lu X, Sonenberg N, Xu X, Zhang L, Yu J. Abstract 2417: eIF4E phosphorylation licenses Myc-driven metabolic and stress reprogramming Cancer Research. 78: 2417-2417. DOI: 10.1158/1538-7445.Am2018-2417  0.41
2018 Ebrahimian T, Dierick F, Simon D, Goncalves C, Sonenberg N, Del Rincon SV, Lehoux S. Inhibition of eIF4E Phosphorylation Regulates Plaque Composition Without Affecting Atherosclerosis Development Atherosclerosis Supplements. 32: 90. DOI: 10.1016/J.Atherosclerosissup.2018.04.275  0.319
2017 Cieplak-Rotowska MK, Tarnowski K, Rubin M, Fabian MR, Sonenberg N, Dadlez M, Niedzwiecka A. Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 29080206 DOI: 10.1007/S13361-017-1830-9  0.322
2017 Sonenberg N. Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078415 DOI: 10.1073/Pnas.1716203114  0.347
2017 Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, ... ... Sonenberg N, et al. mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Molecular Cell. PMID 28918902 DOI: 10.1016/J.Molcel.2017.08.013  0.341
2017 Bhat M, Yanagiya A, Graber T, Razumilava N, Bronk S, Zammit D, Zhao Y, Zakaria C, Metrakos P, Pollak M, Sonenberg N, Gores G, Jaramillo M, Morita M, Alain T. Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells. Oncotarget. 8: 50542-50556. PMID 28881582 DOI: 10.18632/Oncotarget.10671  0.376
2017 Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Cole T, Khuong TM, Mir E, Gibson DG, Wieskopf JS, ... ... Sonenberg N, et al. Epiregulin and EGFR interactions are involved in pain processing. The Journal of Clinical Investigation. PMID 28783046 DOI: 10.1172/Jci87406  0.758
2017 Araki K, Morita M, Bederman AG, Konieczny BT, Kissick HT, Sonenberg N, Ahmed R. Translation is actively regulated during the differentiation of CD8(+) effector T cells. Nature Immunology. PMID 28714979 DOI: 10.1038/Ni.3795  0.365
2017 Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nature Communications. 8: 16056. PMID 28685749 DOI: 10.1038/Ncomms16056  0.478
2017 Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, ... ... Sonenberg N, et al. The MNK - eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28674170 DOI: 10.1523/Jneurosci.0220-17.2017  0.791
2017 Robichaud N, Sonenberg N. Translational control and the cancer cell response to stress. Current Opinion in Cell Biology. 45: 102-109. PMID 28582681 DOI: 10.1016/J.Ceb.2017.05.007  0.326
2017 Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, ... ... Sonenberg N, et al. Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nature Medicine. PMID 28504725 DOI: 10.1038/Nm.4335  0.782
2017 Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. Cap-binding protein 4EHP effects translation silencing by microRNAs. Proceedings of the National Academy of Sciences of the United States of America. PMID 28487484 DOI: 10.1073/Pnas.1701488114  0.753
2017 Tuttle AH, Tansley S, Dossett K, Tohyama S, Khoutorsky A, Maldonado-Bouchard S, Stein L, Gerstein L, Crawhall-Duk H, Pearl R, Sukosd M, Leger P, Hardt OM, Yachnin D, Austin JS, ... ... Sonenberg N, et al. Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484016 DOI: 10.1073/Pnas.1703477114  0.747
2017 Svitkin YV, Cheng YM, Chakraborty T, Presnyak V, John M, Sonenberg N. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Research. PMID 28334758 DOI: 10.1093/Nar/Gkx135  0.45
2017 Wu E, Vashisht AA, Chapat C, Flamand MN, Cohen E, Sarov M, Tabach Y, Sonenberg N, Wohlschlegel J, Duchaine TF. A continuum of mRNP complexes in embryonic microRNA-mediated silencing. Nucleic Acids Research. 45: 2081-2098. PMID 28204614 DOI: 10.1093/Nar/Gkw872  0.372
2017 Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Ohlund D, Hammell M, Crawford H, Schmidt E, Thompson C, Pappin D, Sonenberg N, Tuveson D. Abstract PR03: NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Transcontrol16-Pr03  0.416
2017 Morita M, Prudent J, McBride H, Bergeron J, Sonenberg N. Abstract B06: Translational control of mitochondria through mTORC1/4E-BP signaling pathway Cancer Research. 77. DOI: 10.1158/1538-7445.Transcontrol16-B06  0.421
2016 Kauwe G, Tsurudome K, Penney J, Mori M, Gray L, Calderon MR, Elazouzzi F, Chicoine N, Sonenberg N, Haghighi AP. Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism. Neuron. PMID 27916456 DOI: 10.1016/J.Neuron.2016.10.063  0.364
2016 Siddiqui N, Sonenberg N. Proposing a mechanism of action for ataluren. Proceedings of the National Academy of Sciences of the United States of America. 113: 12353-12355. PMID 27791186 DOI: 10.1073/Pnas.1615548113  0.437
2016 Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, ... ... Sonenberg N, et al. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791185 DOI: 10.1073/Pnas.1615540113  0.816
2016 Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, ... Sonenberg N, et al. eIF2α phosphorylation controls thermal nociception. Proceedings of the National Academy of Sciences of the United States of America. PMID 27698114 DOI: 10.1073/Pnas.1614047113  0.789
2016 Tsukumo Y, Sonenberg N, Alain T. Transcriptional induction of 4E-BP3 prolongs translation repression. Cell Cycle (Georgetown, Tex.). 0. PMID 27565030 DOI: 10.1080/15384101.2016.1224786  0.383
2016 Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes & Development. PMID 27492367 DOI: 10.1101/Gad.282756.116  0.409
2016 Chio II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, ... ... Sonenberg N, et al. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell. PMID 27477511 DOI: 10.1016/J.Cell.2016.06.056  0.355
2016 Penney J, Tsurudome K, Liao EH, Kauwe G, Gray L, Yanagiya A, R Calderon M, Sonenberg N, Haghighi AP. LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Nature Communications. 7: 12188. PMID 27432119 DOI: 10.1038/Ncomms12188  0.303
2016 Zuberek J, Kuchta K, Hernández G, Sonenberg N, Ginalski K. Diverse cap-binding properties of Drosophila eIF4E isoforms. Biochimica Et Biophysica Acta. PMID 27374989 DOI: 10.1016/J.Bbapap.2016.06.015  0.433
2016 Tsukumo Y, Alain T, Fonseca BD, Nadon R, Sonenberg N. Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. Nature Communications. 7: 11776. PMID 27319316 DOI: 10.1038/Ncomms11776  0.415
2016 Hinnebusch AG, Ivanov IP, Sonenberg N. Translational control by 5'-untranslated regions of eukaryotic mRNAs. Science (New York, N.Y.). 352: 1413-6. PMID 27313038 DOI: 10.1126/Science.Aad9868  0.446
2016 So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA. The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Science Signaling. 9: ra57. PMID 27245614 DOI: 10.1126/Scisignal.Aad8463  0.381
2016 Blandino-Rosano M, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender AS, Yanagiya A, Liu M, Rui L, Sonenberg N, Bernal-Mizrachi E. 4E-BP2/SH2B1//IRS2 are part of a novel feedback loop that controls β-cell mass. Diabetes. PMID 27217487 DOI: 10.2337/Db15-1443  0.406
2016 Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, ... ... Sonenberg N, et al. S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3. Nature Immunology. 17: 514-522. PMID 27043414 DOI: 10.1038/Ni.3433  0.342
2016 Skałecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J. mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons. Developmental Neurobiology. PMID 27008592 DOI: 10.1002/Dneu.22392  0.758
2016 Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Rivera K, Öhlund D, Sangar V, Wright K, Fillippi D, Hao Y, Wilkinson JE, Tiriac H, Hammell M, Schmidt E, Park Y, Pappin D, ... Sonenberg N, et al. Abstract PR04: Nrf2 promotes mRNA translation in pancreatic cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-Pr04  0.416
2016 Signer R, Qi L, Zhao Z, Thompson D, Sigova A, Fan ZP, DeMartino G, Young R, Sonenberg N, Morrison S. The low rate of protein synthesis in hematopoietic stem cells is determined partly by hypophosphorylation of 4E-BPS Experimental Hematology. 44: S98. DOI: 10.1016/J.Exphem.2016.06.213  0.333
2015 Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, ... Sonenberg N, et al. Translational control of nociception via 4E-binding protein 1. Elife. 4. PMID 26678009 DOI: 10.7554/Elife.12002  0.805
2015 Siddiqui N, Sonenberg N. Signalling to eIF4E in cancer. Biochemical Society Transactions. 43: 763-72. PMID 26517881 DOI: 10.1042/Bst20150126  0.475
2015 Maity S, Rah S, Sonenberg N, Gkogkas CG, Nguyen PV. Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs. Learning & Memory (Cold Spring Harbor, N.Y.). 22: 499-508. PMID 26373828 DOI: 10.1101/Lm.039222.115  0.669
2015 Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11125-32. PMID 26245973 DOI: 10.1523/Jneurosci.4615-14.2015  0.805
2015 Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Müller C, Calkhoven CF. Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. Embo Reports. PMID 26113365 DOI: 10.15252/Embr.201439837  0.468
2015 Martínez A, Sesé M, Losa JH, Robichaud N, Sonenberg N, Aasen T, Ramón Y Cajal S. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. Plos One. 10: e0123352. PMID 25923732 DOI: 10.1371/Journal.Pone.0123352  0.379
2015 Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N. Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience. 18: 855-62. PMID 25915475 DOI: 10.1038/Nn.4010  0.79
2015 Aulas A, Caron G, Gkogkas CG, Mohamed NV, Destroismaisons L, Sonenberg N, Leclerc N, Parker JA, Vande Velde C. G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. The Journal of Cell Biology. 209: 73-84. PMID 25847539 DOI: 10.1083/Jcb.201408092  0.695
2015 Arulanandam R, Batenchuk C, Varette O, Zakaria C, Garcia V, Forbes NE, Davis C, Krishnan R, Karmacharya R, Cox J, Sinha A, Babawy A, Waite K, Weinstein E, Falls T, ... ... Sonenberg N, et al. Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing. Nature Communications. 6: 6410. PMID 25817275 DOI: 10.1038/Ncomms7410  0.327
2015 Filipowicz W, Sonenberg N. The long unfinished march towards understanding microRNA-mediated repression. Rna (New York, N.Y.). 21: 519-24. PMID 25780122 DOI: 10.1261/Rna.051219.115  0.54
2015 Liberman N, Gandin V, Svitkin YV, David M, Virgili G, Jaramillo M, Holcik M, Nagar B, Kimchi A, Sonenberg N. DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation. Nucleic Acids Research. 43: 3764-75. PMID 25779044 DOI: 10.1093/Nar/Gkv205  0.478
2015 Bhat M, Robichaud N, Hulea L, Sonenberg N, Pelletier J, Topisirovic I. Targeting the translation machinery in cancer. Nature Reviews. Drug Discovery. 14: 261-78. PMID 25743081 DOI: 10.1038/Nrd4505  0.373
2015 Sinvani H, Haimov O, Svitkin Y, Sonenberg N, Tamarkin-Ben-Harush A, Viollet B, Dikstein R. Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection. Cell Metabolism. 21: 479-92. PMID 25738462 DOI: 10.1016/J.Cmet.2015.02.010  0.344
2015 Pelletier J, Graff J, Ruggero D, Sonenberg N. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Research. 75: 250-63. PMID 25593033 DOI: 10.1158/0008-5472.Can-14-2789  0.419
2015 Bah A, Vernon RM, Siddiqui Z, Krzeminski M, Muhandiram R, Zhao C, Sonenberg N, Kay LE, Forman-Kay JD. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature. 519: 106-9. PMID 25533957 DOI: 10.1038/Nature13999  0.426
2015 Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, ... ... Sonenberg N, et al. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature. 517: 497-500. PMID 25383520 DOI: 10.1038/Nature13896  0.359
2015 Robichaud N, del Rincon SV, Huor B, Alain T, Petruccelli LA, Hearnden J, Goncalves C, Grotegut S, Spruck CH, Furic L, Larsson O, Muller WJ, Miller WH, Sonenberg N. Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3. Oncogene. 34: 2032-42. PMID 24909168 DOI: 10.1038/Onc.2014.146  0.416
2015 Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J. The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner. Oncogene. 34: 1729-35. PMID 24837366 DOI: 10.1038/Onc.2014.110  0.363
2015 Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, Koninck YD, Cervero F, Mogil JS, ... Sonenberg N, et al. Author response: Translational control of nociception via 4E-binding protein 1 Elife. DOI: 10.7554/Elife.12002.015  0.717
2015 Pyronnet S, Lasfargues C, Martineau Y, Müller D, Hess DA, DiRenzo D, Khoutorsky A, Baer R, Guillermet-Guibert J, Sonenberg N, Konieczny SF, Bousquet C. Translational regulation of exocrine cell function and survival by ATF4-dependent expression of 4E-BP1 Pancreatology. 15: S48. DOI: 10.1016/J.Pan.2015.05.196  0.347
2014 Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N. Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. Cell Reports. 9: 1742-55. PMID 25466251 DOI: 10.1016/J.Celrep.2014.10.064  0.807
2014 Fukao A, Mishima Y, Takizawa N, Oka S, Imataka H, Pelletier J, Sonenberg N, Thoma C, Fujiwara T. MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans. Molecular Cell. 56: 79-89. PMID 25280105 DOI: 10.1016/J.Molcel.2014.09.005  0.452
2014 Topisirovic I, Sonenberg N. Distinctive tRNA repertoires in proliferating versus differentiating cells. Cell. 158: 1238-9. PMID 25215483 DOI: 10.1016/J.Cell.2014.08.031  0.369
2014 Ramon Y Cajal S, De Mattos-Arruda L, Sonenberg N, Cortes J, Peg V. The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets. Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 16: 937-41. PMID 25060567 DOI: 10.1007/S12094-014-1203-9  0.31
2014 Rouya C, Siddiqui N, Morita M, Duchaine TF, Fabian MR, Sonenberg N. Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1. Rna (New York, N.Y.). 20: 1398-409. PMID 25035296 DOI: 10.1261/Rna.045302.114  0.378
2014 Sun Y, Atas E, Lindqvist LM, Sonenberg N, Pelletier J, Meller A. Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding. Structure (London, England : 1993). 22: 941-8. PMID 24909782 DOI: 10.1016/J.Str.2014.04.014  0.317
2014 Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, et al. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E2319-28. PMID 24843127 DOI: 10.1073/Pnas.1323066111  0.368
2014 Piccirillo CA, Bjur E, Topisirovic I, Sonenberg N, Larsson O. Translational control of immune responses: from transcripts to translatomes. Nature Immunology. 15: 503-11. PMID 24840981 DOI: 10.1038/Ni.2891  0.384
2014 Jung H, Gkogkas CG, Sonenberg N, Holt CE. Remote control of gene function by local translation. Cell. 157: 26-40. PMID 24679524 DOI: 10.1016/J.Cell.2014.03.005  0.77
2014 Yamamoto K, Gandin V, Sasaki M, McCracken S, Li W, Silvester JL, Elia AJ, Wang F, Wakutani Y, Alexandrova R, Oo YD, Mullen PJ, Inoue S, Itsumi M, Lapin V, ... ... Sonenberg N, et al. Largen: a molecular regulator of mammalian cell size control. Molecular Cell. 53: 904-15. PMID 24656129 DOI: 10.1016/J.Molcel.2014.02.028  0.327
2014 Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu-Baur JR, Teodoro JG, ... ... Sonenberg N, et al. Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell. 14: 606-16. PMID 24630793 DOI: 10.1016/J.Stem.2014.02.005  0.813
2014 Gigoux M, Lovato A, Leconte J, Leung J, Sonenberg N, Suh WK. Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation. Molecular Immunology. 59: 46-54. PMID 24486724 DOI: 10.1016/J.Molimm.2014.01.008  0.315
2014 Martineau Y, Wang X, Alain T, Petroulakis E, Shahbazian D, Fabre B, Bousquet-Dubouch MP, Monsarrat B, Pyronnet S, Sonenberg N. Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase. Molecular and Cellular Biology. 34: 1046-53. PMID 24396066 DOI: 10.1128/Mcb.01079-13  0.448
2014 Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Parallel measurement of dynamic changes in translation rates in single cells. Nature Methods. 11: 86-93. PMID 24213167 DOI: 10.1038/Nmeth.2729  0.429
2014 Hall C, Dumstorf C, Konicek B, Robichaud N, McNulty A, Parsons S, Pelltier J, Sonenberg N, Graff JR. Abstract LB-302: eIF4E phosphorylation is Mnk-dependent but does not require assembly of the eIF4F translation initiation complex Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-302  0.455
2014 Faller W, Jackson T, Ridgway R, Knight J, Jamieson T, Pende M, Ryazanov A, Sonenberg N, Meyuhas O, Bushell M, Hall M, Willis A, Sansom O. PWE-021 Mtorc1 Mediated Translational Elongation Is Limiting For Intestinal Tumour Initiation And Growth Gut. 63: A130.2-A131. DOI: 10.1136/Gutjnl-2014-307263.281  0.355
2013 Gkogkas CG, Sonenberg N. Translational control and autism-like behaviors. Cellular Logistics. 3: e24551. PMID 24516777 DOI: 10.4161/Cl.24551  0.697
2013 Lukhele S, Bah A, Lin H, Sonenberg N, Forman-Kay JD. Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface. Structure (London, England : 1993). 21: 2186-96. PMID 24207126 DOI: 10.1016/J.Str.2013.08.030  0.399
2013 Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, ... ... Sonenberg N, et al. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metabolism. 18: 698-711. PMID 24206664 DOI: 10.1016/J.Cmet.2013.10.001  0.438
2013 Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N. Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron. 79: 712-24. PMID 23972597 DOI: 10.1016/J.Neuron.2013.06.026  0.823
2013 Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, ... ... Sonenberg N, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2: e00498. PMID 23741617 DOI: 10.7554/Elife.00498  0.699
2013 Hernández G, Miron M, Han H, Liu N, Magescas J, Tettweiler G, Frank F, Siddiqui N, Sonenberg N, Lasko P. Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster. Molecular and Cellular Biology. 33: 2854-64. PMID 23716590 DOI: 10.1128/Mcb.01354-12  0.519
2013 Svitkin YV, Yanagiya A, Karetnikov AE, Alain T, Fabian MR, Khoutorsky A, Perreault S, Topisirovic I, Sonenberg N. Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. Plos Biology. 11: e1001564. PMID 23700384 DOI: 10.1371/Journal.Pbio.1001564  0.712
2013 Bjur E, Larsson O, Yurchenko E, Zheng L, Gandin V, Topisirovic I, Li S, Wagner CR, Sonenberg N, Piccirillo CA. Distinct translational control in CD4+ T cell subsets. Plos Genetics. 9: e1003494. PMID 23658533 DOI: 10.1371/Journal.Pgen.1003494  0.358
2013 Fabian MR, Frank F, Rouya C, Siddiqui N, Lai WS, Karetnikov A, Blackshear PJ, Nagar B, Sonenberg N. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nature Structural & Molecular Biology. 20: 735-9. PMID 23644599 DOI: 10.1038/Nsmb.2572  0.411
2013 Khoutorsky A, Yanagiya A, Gkogkas CG, Fabian MR, Prager-Khoutorsky M, Cao R, Gamache K, Bouthiette F, Parsyan A, Sorge RE, Mogil JS, Nader K, Lacaille JC, Sonenberg N. Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Neuron. 78: 298-311. PMID 23622065 DOI: 10.1016/J.Neuron.2013.02.025  0.812
2013 Gandin V, Gutierrez GJ, Brill LM, Varsano T, Feng Y, Aza-Blanc P, Au Q, McLaughlan S, Ferreira TA, Alain T, Sonenberg N, Topisirovic I, Ronai ZA. Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex. Molecular and Cellular Biology. 33: 2510-26. PMID 23608534 DOI: 10.1128/Mcb.01362-12  0.412
2013 Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. 154: 1080-91. PMID 23607966 DOI: 10.1016/J.Pain.2013.03.021  0.653
2013 Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V. Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver. Cell Metabolism. 17: 586-98. PMID 23562079 DOI: 10.1016/J.Cmet.2013.03.003  0.655
2013 Fournier MJ, Coudert L, Mellaoui S, Adjibade P, Gareau C, Côté MF, Sonenberg N, Gaudreault RC, Mazroui R. Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation. Molecular and Cellular Biology. 33: 2285-301. PMID 23547259 DOI: 10.1128/Mcb.01517-12  0.437
2013 Virgili G, Frank F, Feoktistova K, Sawicki M, Sonenberg N, Fraser CS, Nagar B. Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A. Structure (London, England : 1993). 21: 517-27. PMID 23478064 DOI: 10.1016/J.Str.2013.01.015  0.403
2013 Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa T, Nakayama H, Uno Y, Horie K, Nishida K, Sonenberg N, Shah AM, Takeda J, et al. Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period. The Journal of Biological Chemistry. 288: 10176-87. PMID 23426372 DOI: 10.1074/Jbc.M112.423640  0.317
2013 Bhat M, Sonenberg N, Gores GJ. The mTOR pathway in hepatic malignancies. Hepatology (Baltimore, Md.). 58: 810-8. PMID 23408390 DOI: 10.1002/Hep.26323  0.321
2013 Ran I, Gkogkas CG, Vasuta C, Tartas M, Khoutorsky A, Laplante I, Parsyan A, Nevarko T, Sonenberg N, Lacaille JC. Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1872-86. PMID 23365227 DOI: 10.1523/Jneurosci.3264-12.2013  0.809
2013 Larsson O, Tian B, Sonenberg N. Toward a genome-wide landscape of translational control. Cold Spring Harbor Perspectives in Biology. 5: a012302. PMID 23209130 DOI: 10.1101/Cshperspect.A012302  0.38
2013 Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, ... Sonenberg N, et al. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 493: 371-7. PMID 23172145 DOI: 10.1038/Nature11628  0.819
2013 Sonenberg N. Abstract IA7: Translational control of cancer via eIF4E/4E-BPs Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Ia7  0.448
2012 Alain T, Sonenberg N, Topisirovic I. mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio. Oncotarget. 3: 1491-2. PMID 23455427 DOI: 10.18632/Oncotarget.799  0.445
2012 Hershey JW, Sonenberg N, Mathews MB. Principles of translational control: an overview. Cold Spring Harbor Perspectives in Biology. 4. PMID 23209153 DOI: 10.1101/Cshperspect.A011528  0.386
2012 Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Marcus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N. eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer Research. 72: 6468-76. PMID 23100465 DOI: 10.1158/0008-5472.Can-12-2395  0.418
2012 Mohr I, Sonenberg N. Host translation at the nexus of infection and immunity. Cell Host & Microbe. 12: 470-83. PMID 23084916 DOI: 10.1016/J.Chom.2012.09.006  0.325
2012 Frank F, Hauver J, Sonenberg N, Nagar B. Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. The Embo Journal. 31: 3588-95. PMID 22850669 DOI: 10.1038/Emboj.2012.204  0.337
2012 Hernández G, Han H, Gandin V, Fabian L, Ferreira T, Zuberek J, Sonenberg N, Brill JA, Lasko P. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development (Cambridge, England). 139: 3211-20. PMID 22833128 DOI: 10.1242/Dev.073122  0.444
2012 Sonenberg N, Filipowicz W. Retrospective. Aaron Shatkin (1934-2012). Science (New York, N.Y.). 337: 309. PMID 22822142 DOI: 10.1126/Science.1226820  0.492
2012 Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, ... ... Sonenberg N, et al. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Molecular and Cellular Biology. 32: 3585-93. PMID 22751931 DOI: 10.1128/Mcb.00455-12  0.641
2012 Tettweiler G, Kowanda M, Lasko P, Sonenberg N, Hernández G. The Distribution of eIF4E-Family Members across Insecta. Comparative and Functional Genomics. 2012: 960420. PMID 22745595 DOI: 10.1155/2012/960420  0.337
2012 Fabian MR, Sonenberg N. The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nature Structural & Molecular Biology. 19: 586-93. PMID 22664986 DOI: 10.1038/Nsmb.2296  0.306
2012 Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ, Pollak M, Sonenberg N. Distinct perturbation of the translatome by the antidiabetic drug metformin. Proceedings of the National Academy of Sciences of the United States of America. 109: 8977-82. PMID 22611195 DOI: 10.1073/Pnas.1201689109  0.468
2012 Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N. Translational homeostasis via the mRNA cap-binding protein, eIF4E. Molecular Cell. 46: 847-58. PMID 22578813 DOI: 10.1016/J.Molcel.2012.04.004  0.495
2012 Herdy B, Jaramillo M, Svitkin YV, Rosenfeld AB, Kobayashi M, Walsh D, Alain T, Sean P, Robichaud N, Topisirovic I, Furic L, Dowling RJ, Sylvestre A, Rong L, Colina R, ... ... Sonenberg N, et al. Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E. Nature Immunology. 13: 543-50. PMID 22544393 DOI: 10.1038/Ni.2291  0.406
2012 Srivastava T, Fortin DA, Nygaard S, Kaech S, Sonenberg N, Edelman AM, Soderling TR. Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5620-30. PMID 22514323 DOI: 10.1523/Jneurosci.0030-12.2012  0.422
2012 Penney J, Tsurudome K, Liao EH, Elazzouzi F, Livingstone M, Gonzalez M, Sonenberg N, Haghighi AP. TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Neuron. 74: 166-78. PMID 22500638 DOI: 10.1016/J.Neuron.2012.01.030  0.379
2012 Sun Y, Atas E, Lindqvist L, Sonenberg N, Pelletier J, Meller A. The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase. Nucleic Acids Research. 40: 6199-207. PMID 22457067 DOI: 10.1093/Nar/Gks278  0.41
2012 Lin J, Fabian M, Sonenberg N, Meller A. Nanopore detachment kinetics of poly(A) binding proteins from RNA molecules reveals the critical role of C-terminus interactions. Biophysical Journal. 102: 1427-34. PMID 22455926 DOI: 10.1016/J.Bpj.2012.02.025  0.39
2012 Li Z, Miard S, Laplante M, Sonenberg N, Picard F. Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway. Molecular and Cellular Endocrinology. 358: 63-8. PMID 22410287 DOI: 10.1016/J.Mce.2012.02.022  0.346
2012 Kundu P, Fabian MR, Sonenberg N, Bhattacharyya SN, Filipowicz W. HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic Acids Research. 40: 5088-100. PMID 22362743 DOI: 10.1093/Nar/Gks148  0.593
2012 Nogueira V, Sundararajan D, Kwan JM, Peng XD, Sarvepalli N, Sonenberg N, Hay N. Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. The Embo Journal. 31: 1134-46. PMID 22307088 DOI: 10.1038/Emboj.2011.478  0.458
2012 Delbes G, Yanagiya A, Sonenberg N, Robaire B. PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse. Biology of Reproduction. 86: 95. PMID 22190698 DOI: 10.1095/Biolreprod.111.092619  0.39
2012 Fujiwara T, Fukao A, Sasano Y, Matsuzaki H, Kikkawa U, Imataka H, Inoue K, Endo S, Sonenberg N, Thoma C, Sakamoto H. Functional and direct interaction between the RNA binding protein HuD and active Akt1. Nucleic Acids Research. 40: 1944-53. PMID 22075994 DOI: 10.1093/Nar/Gkr979  0.446
2012 Pons B, Armengol G, Livingstone M, López L, Coch L, Sonenberg N, Ramón y Cajal S. Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells. Oncology Reports. 27: 225-31. PMID 21922152 DOI: 10.3892/Or.2011.1462  0.43
2011 Marcet-Palacios M, Duggan BL, Shostak I, Barry M, Geskes T, Wilkins JA, Yanagiya A, Sonenberg N, Bleackley RC. Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3. Plos Pathogens. 7: e1002447. PMID 22194691 DOI: 10.1371/Journal.Ppat.1002447  0.372
2011 Topisirovic I, Sonenberg N. mRNA translation and energy metabolism in cancer: the role of the MAPK and mTORC1 pathways. Cold Spring Harbor Symposia On Quantitative Biology. 76: 355-67. PMID 22123850 DOI: 10.1101/Sqb.2011.76.010785  0.441
2011 Vosler PS, Gao Y, Brennan CS, Yanagiya A, Gan Y, Cao G, Zhang F, Morley SJ, Sonenberg N, Bennett MV, Chen J. Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death. Proceedings of the National Academy of Sciences of the United States of America. 108: 18102-7. PMID 22006312 DOI: 10.1073/Pnas.1112635108  0.363
2011 Fabian MR, Cieplak MK, Frank F, Morita M, Green J, Srikumar T, Nagar B, Yamamoto T, Raught B, Duchaine TF, Sonenberg N. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nature Structural & Molecular Biology. 18: 1211-7. PMID 21984185 DOI: 10.1038/Nsmb.2149  0.749
2011 Topisirovic I, Svitkin YV, Sonenberg N, Shatkin AJ. Cap and cap-binding proteins in the control of gene expression. Wiley Interdisciplinary Reviews. Rna. 2: 277-98. PMID 21957010 DOI: 10.1002/Wrna.52  0.677
2011 Melemedjian OK, Asiedu MN, Tillu DV, Sanoja R, Yan J, Lark A, Khoutorsky A, Johnson J, Peebles KA, Lepow T, Sonenberg N, Dussor G, Price TJ. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Molecular Pain. 7: 70. PMID 21936900 DOI: 10.1186/1744-8069-7-70  0.679
2011 Burley SK, Sonenberg N. Gimme phospho-serine five! Capping enzyme guanylyltransferase recognition of the RNA polymerase II CTD. Molecular Cell. 43: 163-5. PMID 21777807 DOI: 10.1016/J.Molcel.2011.07.003  0.31
2011 Elfakess R, Sinvani H, Haimov O, Svitkin Y, Sonenberg N, Dikstein R. Unique translation initiation of mRNAs-containing TISU element. Nucleic Acids Research. 39: 7598-609. PMID 21705780 DOI: 10.1093/Nar/Gkr484  0.362
2011 Burke JD, Sonenberg N, Platanias LC, Fish EN. Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3. Antiviral Therapy. 16: 577-84. PMID 21685545 DOI: 10.3851/Imp1752  0.333
2011 Topisirovic I, Sonenberg N. Translational control by the eukaryotic ribosome. Cell. 145: 333-4. PMID 21529706 DOI: 10.1016/J.Cell.2011.04.006  0.417
2011 Jaramillo M, Gomez MA, Larsson O, Shio MT, Topisirovic I, Contreras I, Luxenburg R, Rosenfeld A, Colina R, McMaster RW, Olivier M, Costa-Mattioli M, Sonenberg N. Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host & Microbe. 9: 331-41. PMID 21501832 DOI: 10.1016/J.Chom.2011.03.008  0.379
2011 Frank F, Fabian MR, Stepinski J, Jemielity J, Darzynkiewicz E, Sonenberg N, Nagar B. Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain. Embo Reports. 12: 415-20. PMID 21475248 DOI: 10.1038/Embor.2011.48  0.415
2011 Parsyan A, Svitkin Y, Shahbazian D, Gkogkas C, Lasko P, Merrick WC, Sonenberg N. mRNA helicases: the tacticians of translational control. Nature Reviews. Molecular Cell Biology. 12: 235-45. PMID 21427765 DOI: 10.1038/Nrm3083  0.741
2011 Larsson O, Sonenberg N, Nadon R. anota: Analysis of differential translation in genome-wide studies. Bioinformatics (Oxford, England). 27: 1440-1. PMID 21422072 DOI: 10.1093/Bioinformatics/Btr146  0.382
2011 Konicek BW, Stephens JR, McNulty AM, Robichaud N, Peery RB, Dumstorf CA, Dowless MS, Iversen PW, Parsons S, Ellis KE, McCann DJ, Pelletier J, Furic L, Yingling JM, Stancato LF, ... Sonenberg N, et al. Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Research. 71: 1849-57. PMID 21233335 DOI: 10.1158/0008-5472.Can-10-3298  0.378
2011 Alvarez-Saavedra M, Antoun G, Yanagiya A, Oliva-Hernandez R, Cornejo-Palma D, Perez-Iratxeta C, Sonenberg N, Cheng HY. miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock. Human Molecular Genetics. 20: 731-51. PMID 21118894 DOI: 10.1093/Hmg/Ddq519  0.321
2011 Sun Y, Atas E, Lindqvist L, Pelletier J, Sonenberg N, Meller A. Single-Molecule Studies of the Effects of Small Compounds on the Activity of Translation Initiation Factor eIF4A Biophysical Journal. 100: 192a. DOI: 10.1016/J.Bpj.2010.12.1266  0.409
2010 Larsson O, Sonenberg N, Nadon R. Identification of differential translation in genome wide studies. Proceedings of the National Academy of Sciences of the United States of America. 107: 21487-92. PMID 21115840 DOI: 10.1073/Pnas.1006821107  0.366
2010 Dumstorf CA, Konicek BW, McNulty AM, Parsons SH, Furic L, Sonenberg N, Graff JR. Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis. Molecular Cancer Therapeutics. 9: 3158-63. PMID 20971826 DOI: 10.1158/1535-7163.Mct-10-0413  0.408
2010 Shahbazian D, Parsyan A, Petroulakis E, Hershey J, Sonenberg N. eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways. Cell Cycle (Georgetown, Tex.). 9: 4106-9. PMID 20948310 DOI: 10.4161/Cc.9.20.13630  0.475
2010 Yanagiya A, Delbes G, Svitkin YV, Robaire B, Sonenberg N. The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice. The Journal of Clinical Investigation. 120: 3389-400. PMID 20739757 DOI: 10.1172/Jci43350  0.455
2010 Gkogkas C, Sonenberg N, Costa-Mattioli M. Translational control mechanisms in long-lasting synaptic plasticity and memory. The Journal of Biological Chemistry. 285: 31913-7. PMID 20693284 DOI: 10.1074/Jbc.R110.154476  0.68
2010 Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 107: 14134-9. PMID 20679199 DOI: 10.1073/Pnas.1005320107  0.398
2010 Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, ... ... Sonenberg N, et al. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. The Journal of Clinical Investigation. 120: 2805-16. PMID 20644257 DOI: 10.1172/Jci43008  0.371
2010 Schrufer TL, Antonetti DA, Sonenberg N, Kimball SR, Gardner TW, Jefferson LS. Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes. 59: 2107-16. PMID 20547975 DOI: 10.2337/Db10-0148  0.373
2010 Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annual Review of Biochemistry. 79: 351-79. PMID 20533884 DOI: 10.1146/Annurev-Biochem-060308-103103  0.575
2010 Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (New York, N.Y.). 328: 1172-6. PMID 20508131 DOI: 10.1126/Science.1187532  0.373
2010 Frank F, Sonenberg N, Nagar B. Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature. 465: 818-22. PMID 20505670 DOI: 10.1038/Nature09039  0.332
2010 Livingstone M, Atas E, Meller A, Sonenberg N. Mechanisms governing the control of mRNA translation. Physical Biology. 7: 021001. PMID 20463379 DOI: 10.1088/1478-3975/7/2/021001  0.435
2010 Sadovski O, Jaikaran AS, Samanta S, Fabian MR, Dowling RJ, Sonenberg N, Woolley GA. A collection of caged compounds for probing roles of local translation in neurobiology. Bioorganic & Medicinal Chemistry. 18: 7746-52. PMID 20427189 DOI: 10.1016/J.Bmc.2010.04.005  0.351
2010 Bidinosti M, Martineau Y, Frank F, Sonenberg N. Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain. The Journal of Biological Chemistry. 285: 19402-8. PMID 20424163 DOI: 10.1074/Jbc.M110.120774  0.417
2010 Bidinosti M, Ran I, Sanchez-Carbente MR, Martineau Y, Gingras AC, Gkogkas C, Raught B, Bramham CR, Sossin WS, Costa-Mattioli M, DesGroseillers L, Lacaille JC, Sonenberg N. Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Molecular Cell. 37: 797-808. PMID 20347422 DOI: 10.1016/J.Molcel.2010.02.022  0.807
2010 Topisirovic I, Sonenberg N. Cell biology. Burn out or fade away? Science (New York, N.Y.). 327: 1210-1. PMID 20203039 DOI: 10.1126/Science.1187497  0.329
2010 Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N, Lotan R. Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prevention Research (Philadelphia, Pa.). 3: 331-8. PMID 20145189 DOI: 10.1158/1940-6207.Capr-09-0076  0.375
2010 Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell. 140: 338-48. PMID 20144759 DOI: 10.1016/J.Cell.2010.01.001  0.32
2010 Jinek M, Fabian MR, Coyle SM, Sonenberg N, Doudna JA. Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nature Structural & Molecular Biology. 17: 238-40. PMID 20098421 DOI: 10.1038/Nsmb.1768  0.403
2010 Shahbazian D, Parsyan A, Petroulakis E, Topisirovic I, Martineau Y, Gibbs BF, Svitkin Y, Sonenberg N. Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B. Molecular and Cellular Biology. 30: 1478-85. PMID 20086100 DOI: 10.1128/Mcb.01218-09  0.43
2010 Frank F, Virgili G, Sonenberg N, Nagar B. Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 15-9. PMID 20057060 DOI: 10.1107/S1744309109044315  0.361
2010 Sukarieh R, Sonenberg N, Pelletier J. Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. The Journal of General Virology. 91: 1224-8. PMID 20053821 DOI: 10.1099/Vir.0.018069-0  0.466
2010 Dowling RJ, Topisirovic I, Fonseca BD, Sonenberg N. Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochimica Et Biophysica Acta. 1804: 433-9. PMID 20005306 DOI: 10.1016/J.Bbapap.2009.12.001  0.339
2010 Delbes G, Yanagiya A, Sonenberg N, Robaire B. PABP Interacting Protein 2 (Paip2) Regulates the Translation of Key Proteins Involved inSpermiogenesis. Biology of Reproduction. 83: 137-137. DOI: 10.1093/Biolreprod/83.S1.137  0.408
2010 Burke D, Sonenberg N, Platanias LC, Fish EN. PS2-77 IFN-mediated regulation of protein translation and its role in an antiviral immune response Cytokine. 52: 66. DOI: 10.1016/J.Cyto.2010.07.282  0.347
2009 Costa-Mattioli M, Sonenberg N, Richter JD. Translational regulatory mechanisms in synaptic plasticity and memory storage. Progress in Molecular Biology and Translational Science. 90: 293-311. PMID 20374745 DOI: 10.1016/S1877-1173(09)90008-4  0.341
2009 Fukao A, Sasano Y, Imataka H, Inoue K, Sakamoto H, Sonenberg N, Thoma C, Fujiwara T. The ELAV protein HuD stimulates cap-dependent translation in a Poly(A)- and eIF4A-dependent manner. Molecular Cell. 36: 1007-17. PMID 20064466 DOI: 10.1016/J.Molcel.2009.11.013  0.469
2009 Livingstone M, Larsson O, Sukarieh R, Pelletier J, Sonenberg N. A chemical genetic screen for mTOR pathway inhibitors based on 4E-BP-dependent nuclear accumulation of eIF4E. Chemistry & Biology. 16: 1240-9. PMID 20064434 DOI: 10.1016/J.Chembiol.2009.11.010  0.312
2009 Parsyan A, Shahbazian D, Martineau Y, Petroulakis E, Alain T, Larsson O, Mathonnet G, Tettweiler G, Hellen CU, Pestova TV, Svitkin YV, Sonenberg N. The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 22217-22. PMID 20018725 DOI: 10.1073/Pnas.0909773106  0.443
2009 Petroulakis E, Parsyan A, Dowling RJ, LeBacquer O, Martineau Y, Bidinosti M, Larsson O, Alain T, Rong L, Mamane Y, Paquet M, Furic L, Topisirovic I, Shahbazian D, Livingstone M, ... ... Sonenberg N, et al. p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell. 16: 439-46. PMID 19878875 DOI: 10.1016/J.Ccr.2009.09.025  0.405
2009 Kanaan AS, Frank F, Maedler-Kron C, Verma K, Sonenberg N, Nagar B. Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 1060-4. PMID 19851022 DOI: 10.1107/S1744309109036513  0.301
2009 Panja D, Dagyte G, Bidinosti M, Wibrand K, Kristiansen AM, Sonenberg N, Bramham CR. Novel translational control in Arc-dependent long term potentiation consolidation in vivo. The Journal of Biological Chemistry. 284: 31498-511. PMID 19755425 DOI: 10.1074/Jbc.M109.056077  0.688
2009 Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR, Hannon GJ, Filipowicz W, ... ... Sonenberg N, et al. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Molecular Cell. 35: 868-80. PMID 19716330 DOI: 10.1016/J.Molcel.2009.08.004  0.569
2009 Ran I, Laplante I, Bourgeois C, Pépin J, Lacaille P, Costa-Mattioli M, Pelletier J, Sonenberg N, Lacaille JC. Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5605-15. PMID 19403827 DOI: 10.1523/Jneurosci.5355-08.2009  0.787
2009 Santhanam AN, Bindewald E, Rajasekhar VK, Larsson O, Sonenberg N, Colburn NH, Shapiro BA. Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference. Plos One. 4: e4868. PMID 19290046 DOI: 10.1371/Journal.Pone.0004868  0.467
2009 Sukarieh R, Sonenberg N, Pelletier J. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. American Journal of Physiology. Cell Physiology. 296: C1207-17. PMID 19244480 DOI: 10.1152/ajpcell.00511.2008  0.348
2009 Sonenberg N, Hinnebusch AG. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell. 136: 731-45. PMID 19239892 DOI: 10.1016/J.Cell.2009.01.042  0.364
2009 Marintchev A, Edmonds KA, Marintcheva B, Hendrickson E, Oberer M, Suzuki C, Herdy B, Sonenberg N, Wagner G. Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell. 136: 447-60. PMID 19203580 DOI: 10.1016/J.Cell.2009.01.014  0.42
2009 Olson KE, Booth GC, Poulin F, Sonenberg N, Beretta L. Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2. Immunology. 128: e376-84. PMID 19175792 DOI: 10.1111/J.1365-2567.2008.02981.X  0.601
2009 Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. Translational control of long-lasting synaptic plasticity and memory. Neuron. 61: 10-26. PMID 19146809 DOI: 10.1016/J.Neuron.2008.10.055  0.352
2009 Yanagiya A, Svitkin YV, Shibata S, Mikami S, Imataka H, Sonenberg N. Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap. Molecular and Cellular Biology. 29: 1661-9. PMID 19114555 DOI: 10.1128/Mcb.01187-08  0.459
2009 Svitkin YV, Evdokimova VM, Brasey A, Pestova TV, Fantus D, Yanagiya A, Imataka H, Skabkin MA, Ovchinnikov LP, Merrick WC, Sonenberg N. General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. The Embo Journal. 28: 58-68. PMID 19078965 DOI: 10.1038/Emboj.2008.259  0.478
2009 Brenet F, Socci ND, Sonenberg N, Holland EC. Akt phosphorylation of La regulates specific mRNA translation in glial progenitors. Oncogene. 28: 128-39. PMID 18836485 DOI: 10.1038/Onc.2008.376  0.486
2009 Santhanam AN, Bindewald E, Rajasekhar VK, Larsson O, Sonenberg N, Colburn NH, Shapiro BA. Correction: Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference Plos One. 4. DOI: 10.1371/Annotation/6A44204E-5D20-45Bf-Bbce-358Dc9E2De27  0.308
2009 Delbes G, Yanagiya A, Sonenberg N, Robaire B. PABP Interacting Protein 2 (Paip2) Is a Major Translational Regulator Involved in the Maturation of Male Germ Cells and Male Fertility. Biology of Reproduction. 81: 167-167. DOI: 10.1093/Biolreprod/81.S1.167  0.333
2008 Zakikhani M, Dowling RJ, Sonenberg N, Pollak MN. The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prevention Research (Philadelphia, Pa.). 1: 369-75. PMID 19138981 DOI: 10.1158/1940-6207.Capr-08-0081  0.315
2008 Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 134: 1042-54. PMID 18805096 DOI: 10.1016/J.Cell.2008.07.031  0.49
2008 Martineau Y, Derry MC, Wang X, Yanagiya A, Berlanga JJ, Shyu AB, Imataka H, Gehring K, Sonenberg N. Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. Molecular and Cellular Biology. 28: 6658-67. PMID 18725400 DOI: 10.1128/MCB.00738-08  0.399
2008 Aizer A, Brody Y, Ler LW, Sonenberg N, Singer RH, Shav-Tal Y. The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Molecular Biology of the Cell. 19: 4154-66. PMID 18653466 DOI: 10.1091/Mbc.E08-05-0513  0.317
2008 Rong L, Livingstone M, Sukarieh R, Petroulakis E, Gingras AC, Crosby K, Smith B, Polakiewicz RD, Pelletier J, Ferraiuolo MA, Sonenberg N. Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. Rna (New York, N.Y.). 14: 1318-27. PMID 18515545 DOI: 10.1261/Rna.950608  0.608
2008 Sonenberg N. eIF4E, the mRNA cap-binding protein: from basic discovery to translational research. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 86: 178-83. PMID 18443631 DOI: 10.1139/O08-034  0.357
2008 Oliere S, Arguello M, Mesplede T, Tumilasci V, Nakhaei P, Stojdl D, Sonenberg N, Bell J, Hiscott J. Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation. Journal of Virology. 82: 5735-49. PMID 18417567 DOI: 10.1128/Jvi.02601-07  0.327
2008 Costa-Mattioli M, Sonenberg N. Translational control of gene expression: a molecular switch for memory storage. Progress in Brain Research. 169: 81-95. PMID 18394469 DOI: 10.1016/S0079-6123(07)00005-2  0.36
2008 Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y. ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metabolism. 7: 269-76. PMID 18316032 DOI: 10.1016/J.Cmet.2008.01.008  0.321
2008 Colina R, Costa-Mattioli M, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ, Martineau Y, Larsson O, Rong L, Svitkin YV, Makrigiannis AP, Bell JC, Sonenberg N. Translational control of the innate immune response through IRF-7. Nature. 452: 323-8. PMID 18272964 DOI: 10.1038/Nature06730  0.339
2008 Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature Reviews. Genetics. 9: 102-14. PMID 18197166 DOI: 10.1038/Nrg2290  0.623
2008 Burke D, Sonenberg N, Platanias LC, Fish EN. 193 IFN-mediated inactivation of the 4E-BP1 repressor of mRNA translation influences an antiviral response Cytokine. 43: 285. DOI: 10.1016/J.Cyto.2008.07.255  0.402
2007 Sonenberg N, Hinnebusch AG. New modes of translational control in development, behavior, and disease. Molecular Cell. 28: 721-9. PMID 18082597 DOI: 10.1016/J.Molcel.2007.11.018  0.351
2007 Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Research. 67: 10804-12. PMID 18006825 DOI: 10.1158/0008-5472.Can-07-2310  0.423
2007 Svitkin YV, Costa-Mattioli M, Herdy B, Perreault S, Sonenberg N. Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP). Rna (New York, N.Y.). 13: 2330-40. PMID 17942745 DOI: 10.1261/Rna.606407  0.39
2007 Svitkin YV, Sonenberg N. A highly efficient and robust in vitro translation system for expression of picornavirus and hepatitis C virus RNA genomes. Methods in Enzymology. 429: 53-82. PMID 17913619 DOI: 10.1016/S0076-6879(07)29004-4  0.323
2007 Burgui I, Yángüez E, Sonenberg N, Nieto A. Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation? Journal of Virology. 81: 12427-38. PMID 17855553 DOI: 10.1128/Jvi.01105-07  0.404
2007 Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E, Pillai RS, Filipowicz W, Duchaine TF, Sonenberg N. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (New York, N.Y.). 317: 1764-7. PMID 17656684 DOI: 10.1126/Science.1146067  0.61
2007 Gelinas JN, Banko JL, Hou L, Sonenberg N, Weeber EJ, Klann E, Nguyen PV. ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation. The Journal of Biological Chemistry. 282: 27527-35. PMID 17635924 DOI: 10.1074/Jbc.M701077200  0.337
2007 Masutani M, Sonenberg N, Yokoyama S, Imataka H. Reconstitution reveals the functional core of mammalian eIF3. The Embo Journal. 26: 3373-83. PMID 17581632 DOI: 10.1038/Sj.Emboj.7601765  0.373
2007 Hu J, Straub J, Xiao D, Singh SV, Yang HS, Sonenberg N, Vatsyayan J. Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1. Cancer Research. 67: 3569-73. PMID 17440067 DOI: 10.1158/0008-5472.Can-07-0392  0.438
2007 Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjević K, Lacaille JC, Nader K, Sonenberg N. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 129: 195-206. PMID 17418795 DOI: 10.1016/J.Cell.2007.01.050  0.33
2007 Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, Darzynkiewicz E. Weak binding affinity of human 4EHP for mRNA cap analogs. Rna (New York, N.Y.). 13: 691-7. PMID 17369309 DOI: 10.1261/Rna.453107  0.462
2007 Wilker EW, van Vugt MA, Artim SA, Huang PH, Petersen CP, Reinhardt HC, Feng Y, Sharp PA, Sonenberg N, White FM, Yaffe MB. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature. 446: 329-32. PMID 17361185 DOI: 10.1038/Nature05584  0.433
2007 Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. The Journal of Biological Chemistry. 282: 14056-64. PMID 17360704 DOI: 10.1074/Jbc.M700906200  0.369
2007 Mamane Y, Petroulakis E, Martineau Y, Sato TA, Larsson O, Rajasekhar VK, Sonenberg N. Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. Plos One. 2: e242. PMID 17311107 DOI: 10.1371/Journal.Pone.0000242  0.468
2007 Lasko P, Sonenberg N. Coordinated transcriptional and translational control in metabolic homeostasis in flies. Genes & Development. 21: 235-7. PMID 17289913 DOI: 10.1101/Gad.1524707  0.305
2007 Le Bacquer O, Petroulakis E, Paglialunga S, Poulin F, Richard D, Cianflone K, Sonenberg N. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. The Journal of Clinical Investigation. 117: 387-96. PMID 17273556 DOI: 10.1172/Jci29528  0.616
2007 Kaur S, Lal L, Sassano A, Majchrzak-Kita B, Srikanth M, Baker DP, Petroulakis E, Hay N, Sonenberg N, Fish EN, Platanias LC. Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. The Journal of Biological Chemistry. 282: 1757-68. PMID 17114181 DOI: 10.1074/Jbc.M607365200  0.443
2007 Banko JL, Merhav M, Stern E, Sonenberg N, Rosenblum K, Klann E. Behavioral alterations in mice lacking the translation repressor 4E-BP2. Neurobiology of Learning and Memory. 87: 248-56. PMID 17029989 DOI: 10.1016/J.Nlm.2006.08.012  0.38
2007 Schneider RJ, Sonenberg N. 15 Translational Control in Cancer Development and Progression Cold Spring Harbor Monograph Archive. 48: 401-431. DOI: 10.1101/087969767.48.401  0.442
2007 Mathews MB, Sonenberg N, Hershey JWB. 1 Origins and Principles of Translational Control Cold Spring Harbor Monograph Archive. 48: 1-40. DOI: 10.1101/087969767.48.1  0.332
2007 Sonenberg N. Control Of Translation From The mRNA 3′ End The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A45-C  0.376
2006 Khanam T, Muddashetty RS, Kahvejian A, Sonenberg N, Brosius J. Poly(A)-binding protein binds to A-rich sequences via RNA-binding domains 1+2 and 3+4. Rna Biology. 3: 170-7. PMID 17387282 DOI: 10.4161/Rna.3.4.4075  0.79
2006 Derry MC, Yanagiya A, Martineau Y, Sonenberg N. Regulation of poly(A)-binding protein through PABP-interacting proteins. Cold Spring Harbor Symposia On Quantitative Biology. 71: 537-43. PMID 17381337 DOI: 10.1101/Sqb.2006.71.061  0.495
2006 Kanhema T, Dagestad G, Panja D, Tiron A, Messaoudi E, Håvik B, Ying SW, Nairn AC, Sonenberg N, Bramham CR. Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. Journal of Neurochemistry. 99: 1328-37. PMID 17064361 DOI: 10.1111/J.1471-4159.2006.04158.X  0.666
2006 Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Research. 66: 10269-73. PMID 17062558 DOI: 10.1158/0008-5472.Can-06-1500  0.321
2006 Cho PF, Gamberi C, Cho-Park YA, Cho-Park IB, Lasko P, Sonenberg N. Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Current Biology : Cb. 16: 2035-41. PMID 17055983 DOI: 10.1016/J.Cub.2006.08.093  0.463
2006 Sonenberg N, Pause A. Signal transduction. Protein synthesis and oncogenesis meet again. Science (New York, N.Y.). 314: 428-9. PMID 17053135 DOI: 10.1126/Science.1134031  0.374
2006 Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N. mTOR, translation initiation and cancer. Oncogene. 25: 6416-22. PMID 17041626 DOI: 10.1038/Sj.Onc.1209888  0.419
2006 Miyakawa S, Oguro A, Ohtsu T, Imataka H, Sonenberg N, Nakamura Y. RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes. Rna (New York, N.Y.). 12: 1825-34. PMID 16940549 DOI: 10.1261/Rna.2169406  0.489
2006 Svitkin YV, Sonenberg N. [Translational control by the poly(A) binding protein: a check for mRNA integrity]. Molekuliarnaia Biologiia. 40: 684-93. PMID 16913227 DOI: 10.1134/S0026893306040133  0.5
2006 Berlanga JJ, Baass A, Sonenberg N. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. Rna (New York, N.Y.). 12: 1556-68. PMID 16804161 DOI: 10.1261/rna.106506  0.42
2006 Karim MM, Svitkin YV, Kahvejian A, De Crescenzo G, Costa-Mattioli M, Sonenberg N. A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding. Proceedings of the National Academy of Sciences of the United States of America. 103: 9494-9. PMID 16772376 DOI: 10.1073/Pnas.0603701103  0.825
2006 Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The Embo Journal. 25: 2781-91. PMID 16763566 DOI: 10.1038/Sj.Emboj.7601166  0.616
2006 Broxmeyer HE, Ginras AC, Sonenberg N, Cooper S. Retraction. Macrophage inflammatory protein-1alpha and interferon-inducible protein 10 inhibit synergistically induced growth factor stimulation of MAP kinase activity and suppress phosphorylation of eukaryotic initiation factor 4E and 4E binding protein 1. Blood. 107: 4713. PMID 16754774 DOI: 10.1182/Blood-2006-04-019281  0.402
2006 Bellsolell L, Cho-Park PF, Poulin F, Sonenberg N, Burley SK. Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. Structure (London, England : 1993). 14: 913-23. PMID 16698552 DOI: 10.1016/J.Str.2006.03.012  0.638
2006 Berlanga JJ, Ventoso I, Harding HP, Deng J, Ron D, Sonenberg N, Carrasco L, de Haro C. Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. The Embo Journal. 25: 1730-40. PMID 16601681 DOI: 10.1038/Sj.Emboj.7601073  0.396
2006 Yoshida M, Yoshida K, Kozlov G, Lim NS, De Crescenzo G, Pang Z, Berlanga JJ, Kahvejian A, Gehring K, Wing SS, Sonenberg N. Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. The Embo Journal. 25: 1934-44. PMID 16601676 DOI: 10.1038/Sj.Emboj.7601079  0.836
2006 Banko JL, Hou L, Poulin F, Sonenberg N, Klann E. Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2167-73. PMID 16495443 DOI: 10.1523/Jneurosci.5196-05.2006  0.627
2006 Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. The Embo Journal. 25: 1114-25. PMID 16467844 DOI: 10.1038/Sj.Emboj.7600998  0.715
2006 Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D, Sonenberg N. mTOR signaling: implications for cancer and anticancer therapy. British Journal of Cancer. 94: 195-9. PMID 16404421 DOI: 10.1038/Sj.Bjc.6602902  0.38
2006 Evdokimova V, Ruzanov P, Anglesio MS, Sorokin AV, Ovchinnikov LP, Buckley J, Triche TJ, Sonenberg N, Sorensen PH. Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Molecular and Cellular Biology. 26: 277-92. PMID 16354698 DOI: 10.1128/Mcb.26.1.277-292.2006  0.509
2006 Mikami S, Masutani M, Sonenberg N, Yokoyama S, Imataka H. An efficient mammalian cell-free translation system supplemented with translation factors. Protein Expression and Purification. 46: 348-57. PMID 16289705 DOI: 10.1016/J.Pep.2005.09.021  0.452
2006 Svitkin YV, Sonenberg N. Translational control by the poly(A) binding protein: A check for mRNA integrity Molecular Biology. 40: 611-619. DOI: 10.1134/S0026893306040133  0.342
2005 Ruggero D, Sonenberg N. The Akt of translational control. Oncogene. 24: 7426-34. PMID 16288289 DOI: 10.1038/Sj.Onc.1209098  0.458
2005 Svitkin YV, Herdy B, Costa-Mattioli M, Gingras AC, Raught B, Sonenberg N. Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Molecular and Cellular Biology. 25: 10556-65. PMID 16287867 DOI: 10.1128/Mcb.25.23.10556-10565.2005  0.724
2005 Lasko P, Cho P, Poulin F, Sonenberg N. Contrasting mechanisms of regulating translation of specific Drosophila germline mRNAs at the level of 5'-cap structure binding. Biochemical Society Transactions. 33: 1544-6. PMID 16246166 DOI: 10.1042/Bst0331544  0.702
2005 Banko JL, Poulin F, Hou L, DeMaria CT, Sonenberg N, Klann E. The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9581-90. PMID 16237163 DOI: 10.1523/Jneurosci.2423-05.2005  0.612
2005 Ferraiuolo MA, Basak S, Dostie J, Murray EL, Schoenberg DR, Sonenberg N. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. The Journal of Cell Biology. 170: 913-24. PMID 16157702 DOI: 10.1083/Jcb.200504039  0.709
2005 Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M, Imataka H, Cuello AC, Seidah N, Sossin W, Lacaille JC, ... ... Sonenberg N, et al. Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature. 436: 1166-73. PMID 16121183 DOI: 10.1038/Nature03897  0.393
2005 Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Molecular & Cellular Proteomics : McP. 4: 1725-40. PMID 16085932 DOI: 10.1074/Mcp.M500231-Mcp200  0.689
2005 Tettweiler G, Miron M, Jenkins M, Sonenberg N, Lasko PF. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes & Development. 19: 1840-3. PMID 16055649 DOI: 10.1101/Gad.1311805  0.41
2005 Bordeleau ME, Matthews J, Wojnar JM, Lindqvist L, Novac O, Jankowsky E, Sonenberg N, Northcote P, Teesdale-Spittle P, Pelletier J. Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proceedings of the National Academy of Sciences of the United States of America. 102: 10460-5. PMID 16030146 DOI: 10.1073/Pnas.0504249102  0.397
2005 Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. The Journal of Biological Chemistry. 280: 32081-9. PMID 16027121 DOI: 10.1074/Jbc.M502876200  0.346
2005 Gorrini C, Loreni F, Gandin V, Sala LA, Sonenberg N, Marchisio PC, Biffo S. Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways. Proceedings of the National Academy of Sciences of the United States of America. 102: 9200-5. PMID 15961545 DOI: 10.1073/Pnas.0409513102  0.453
2005 Pyronnet S, Pradayrol L, Sonenberg N. Alternative splicing facilitates internal ribosome entry on the ornithine decarboxylase mRNA. Cellular and Molecular Life Sciences : Cmls. 62: 1267-74. PMID 15905964 DOI: 10.1007/S00018-005-5020-8  0.427
2005 Svitkin YV, Pause A, Lopez-Lastra M, Perreault S, Sonenberg N. Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3. Journal of Virology. 79: 6868-81. PMID 15890926 DOI: 10.1128/Jvi.79.11.6868-6881.2005  0.375
2005 Cho PF, Poulin F, Cho-Park YA, Cho-Park IB, Chicoine JD, Lasko P, Sonenberg N. A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell. 121: 411-23. PMID 15882623 DOI: 10.1016/J.Cell.2005.02.024  0.693
2005 Holcik M, Sonenberg N. Translational control in stress and apoptosis. Nature Reviews. Molecular Cell Biology. 6: 318-27. PMID 15803138 DOI: 10.1038/Nrm1618  0.357
2005 Salaün P, Boulben S, Mulner-Lorillon O, Bellé R, Sonenberg N, Morales J, Cormier P. Embryonic-stage-dependent changes in the level of eIF4E-binding proteins during early development of sea urchin embryos. Journal of Cell Science. 118: 1385-94. PMID 15769855 DOI: 10.1242/Jcs.01716  0.402
2005 Ohanna M, Sobering AK, Lapointe T, Lorenzo L, Praud C, Petroulakis E, Sonenberg N, Kelly PA, Sotiropoulos A, Pende M. Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nature Cell Biology. 7: 286-94. PMID 15723049 DOI: 10.1038/Ncb1231  0.31
2005 Richter JD, Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature. 433: 477-80. PMID 15690031 DOI: 10.1038/Nature03205  0.479
2005 Kahvejian A, Svitkin YV, Sukarieh R, M'Boutchou MN, Sonenberg N. Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes & Development. 19: 104-13. PMID 15630022 DOI: 10.1101/Gad.1262905  0.825
2005 Malina A, Khan S, Carlson CB, Svitkin Y, Harvey I, Sonenberg N, Beal PA, Pelletier J. Inhibitory properties of nucleic acid-binding ligands on protein synthesis. Febs Letters. 579: 79-89. PMID 15620694 DOI: 10.1016/J.Febslet.2004.06.103  0.398
2005 Mochizuki K, Oguro A, Ohtsu T, Sonenberg N, Nakamura Y. High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation. Rna (New York, N.Y.). 11: 77-89. PMID 15611299 DOI: 10.1261/Rna.7108205  0.492
2005 Ferraiuolo MA, Basak S, Dostie J, Murray EL, Schoenberg DR, Sonenberg N. Correction: A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay Journal of Cell Biology. 171: 175-175. DOI: 10.1083/Jcb.200504039091905C  0.707
2004 Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Molecular and Cellular Biology. 24: 10161-8. PMID 15542827 DOI: 10.1128/Mcb.24.23.10161-10168.2004  0.357
2004 Baltzis D, Qu LK, Papadopoulou S, Blais JD, Bell JC, Sonenberg N, Koromilas AE. Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. Journal of Virology. 78: 12747-61. PMID 15542627 DOI: 10.1128/Jvi.78.23.12747-12761.2004  0.343
2004 Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, Lee AH, Qian SB, Zhao H, Yu X, Yang L, Tan BK, Rosenwald A, Hurt EM, Petroulakis E, Sonenberg N, Yewdell JW, Calame K, et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity. 21: 81-93. PMID 15345222 DOI: 10.1016/J.Immuni.2004.06.010  0.315
2004 Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB. UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. Genes & Development. 18: 2010-23. PMID 15314026 DOI: 10.1101/Gad.1219104  0.812
2004 Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes & Development. 18: 1926-45. PMID 15314020 DOI: 10.1101/Gad.1212704  0.406
2004 Costa-Mattioli M, Svitkin Y, Sonenberg N. La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro. Molecular and Cellular Biology. 24: 6861-70. PMID 15254251 DOI: 10.1128/Mcb.24.15.6861-6870.2004  0.356
2004 Orton KC, Ling J, Waskiewicz AJ, Cooper JA, Merrick WC, Korneeva NL, Rhoads RE, Sonenberg N, Traugh JA. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. The Journal of Biological Chemistry. 279: 38649-57. PMID 15234964 DOI: 10.1074/Jbc.M407337200  0.351
2004 Avdulov S, Li S, Michalek V, Burrichter D, Peterson M, Perlman DM, Manivel JC, Sonenberg N, Yee D, Bitterman PB, Polunovsky VA. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell. 5: 553-63. PMID 15193258 DOI: 10.1016/J.Ccr.2004.05.024  0.374
2004 Caron S, Charon M, Cramer E, Sonenberg N, Dusanter-Fourt I. Selective modification of eukaryotic initiation factor 4F (eIF4F) at the onset of cell differentiation: recruitment of eIF4GII and long-lasting phosphorylation of eIF4E. Molecular and Cellular Biology. 24: 4920-8. PMID 15143184 DOI: 10.1128/Mcb.24.11.4920-4928.2004  0.464
2004 Mamane Y, Petroulakis E, Rong L, Yoshida K, Ler LW, Sonenberg N. eIF4E--from translation to transformation. Oncogene. 23: 3172-9. PMID 15094766 DOI: 10.1038/Sj.Onc.1207549  0.442
2004 Holland EC, Sonenberg N, Pandolfi PP, Thomas G. Signaling control of mRNA translation in cancer pathogenesis. Oncogene. 23: 3138-44. PMID 15094763 DOI: 10.1038/Sj.Onc.1207590  0.406
2004 Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH. A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Molecular and Cellular Biology. 24: 3894-906. PMID 15082783 DOI: 10.1128/Mcb.24.9.3894-3906.2004  0.349
2004 Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. The Embo Journal. 23: 1761-9. PMID 15071500 DOI: 10.1038/Sj.Emboj.7600193  0.698
2004 van Breukelen F, Sonenberg N, Martin SL. Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: implications for the control of translation during torpor. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 287: R349-53. PMID 15059792 DOI: 10.1152/Ajpregu.00728.2003  0.35
2004 Shibuya T, Tange TØ, Sonenberg N, Moore MJ. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nature Structural & Molecular Biology. 11: 346-51. PMID 15034551 DOI: 10.1038/Nsmb750  0.473
2004 Ferraiuolo MA, Lee CS, Ler LW, Hsu JL, Costa-Mattioli M, Luo MJ, Reed R, Sonenberg N. A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proceedings of the National Academy of Sciences of the United States of America. 101: 4118-23. PMID 15024115 DOI: 10.1073/Pnas.0400933101  0.434
2004 Gradi A, Foeger N, Strong R, Svitkin YV, Sonenberg N, Skern T, Belsham GJ. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. Journal of Virology. 78: 3271-8. PMID 15016848 DOI: 10.1128/Jvi.78.7.3271-3278.2004  0.786
2004 Svitkin YV, Sonenberg N. An efficient system for cap- and poly(A)-dependent translation in vitro. Methods in Molecular Biology (Clifton, N.J.). 257: 155-70. PMID 14770004 DOI: 10.1385/1-59259-750-5:155  0.471
2004 Donzé O, Deng J, Curran J, Sladek R, Picard D, Sonenberg N. The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. The Embo Journal. 23: 564-71. PMID 14749731 DOI: 10.1038/Sj.Emboj.7600078  0.333
2004 Roy G, Miron M, Khaleghpour K, Lasko P, Sonenberg N. The Drosophila poly(A) binding protein-interacting protein, dPaip2, is a novel effector of cell growth. Molecular and Cellular Biology. 24: 1143-54. PMID 14729960 DOI: 10.1128/Mcb.24.3.1143-1154.2004  0.825
2004 Kozlov G, De Crescenzo G, Lim NS, Siddiqui N, Fantus D, Kahvejian A, Trempe JF, Elias D, Ekiel I, Sonenberg N, O'Connor-McCourt M, Gehring K. Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. The Embo Journal. 23: 272-81. PMID 14685257 DOI: 10.1038/Sj.Emboj.7600048  0.771
2004 Gingras AC, Raught B, Sonenberg N. mTOR signaling to translation. Current Topics in Microbiology and Immunology. 279: 169-97. PMID 14560958 DOI: 10.1007/978-3-642-18930-2_11  0.701
2004 Petroulakis E, Sonenberg N. 10 Translation Initiation and Cell Growth Control Cold Spring Harbor Monograph Archive. 42: 299-328. DOI: 10.1101/087969672.42.299  0.384
2003 Miron M, Lasko P, Sonenberg N. Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Molecular and Cellular Biology. 23: 9117-26. PMID 14645523 DOI: 10.1128/Mcb.23.24.9117-9126.2003  0.399
2003 Cormier P, Pyronnet S, Salaün P, Mulner-Lorillon O, Sonenberg N. Cap-dependent translation and control of the cell cycle. Progress in Cell Cycle Research. 5: 469-75. PMID 14593742  0.318
2003 Poulin F, Brueschke A, Sonenberg N. Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. The Journal of Biological Chemistry. 278: 52290-7. PMID 14557257 DOI: 10.1074/Jbc.M310761200  0.669
2003 Qin H, Raught B, Sonenberg N, Goldstein EG, Edelman AM. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. The Journal of Biological Chemistry. 278: 48570-9. PMID 14507913 DOI: 10.1074/Jbc.M308781200  0.585
2003 Lekmine F, Uddin S, Sassano A, Parmar S, Brachmann SM, Majchrzak B, Sonenberg N, Hay N, Fish EN, Platanias LC. Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. The Journal of Biological Chemistry. 278: 27772-80. PMID 12759354 DOI: 10.1074/Jbc.M301364200  0.404
2003 Svitkin YV, Sonenberg N. Cell-free synthesis of encephalomyocarditis virus. Journal of Virology. 77: 6551-5. PMID 12743313 DOI: 10.1128/Jvi.77.11.6551-6555.2003  0.318
2003 Gradi A, Svitkin YV, Sommergruber W, Imataka H, Morino S, Skern T, Sonenberg N. Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. Journal of Virology. 77: 5026-9. PMID 12663812 DOI: 10.1128/Jvi.77.8.5026-5029.2003  0.793
2003 Oguro A, Ohtsu T, Svitkin YV, Sonenberg N, Nakamura Y. RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis. Rna (New York, N.Y.). 9: 394-407. PMID 12649492 DOI: 10.1261/Rna.2161303  0.361
2003 Salaün P, Pyronnet S, Morales J, Mulner-Lorillon O, Bellé R, Sonenberg N, Cormier P. eIF4E/4E-BP dissociation and 4E-BP degradation in the first mitotic division of the sea urchin embryo. Developmental Biology. 255: 428-39. PMID 12648502 DOI: 10.1016/S0012-1606(02)00099-4  0.446
2003 Brasey A, Lopez-Lastra M, Ohlmann T, Beerens N, Berkhout B, Darlix JL, Sonenberg N. The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle. Journal of Virology. 77: 3939-49. PMID 12634354 DOI: 10.1128/Jvi.77.7.3939-3949.2003  0.336
2003 Shi Y, Taylor SI, Tan SL, Sonenberg N. When translation meets metabolism: multiple links to diabetes. Endocrine Reviews. 24: 91-101. PMID 12588811 DOI: 10.1210/Er.2002-0018  0.329
2003 Sonenberg N, Dever TE. Eukaryotic translation initiation factors and regulators. Current Opinion in Structural Biology. 13: 56-63. PMID 12581660 DOI: 10.1016/S0959-440X(03)00009-5  0.432
2003 Zuberek J, Wyslouch-Cieszynska A, Niedzwiecka A, Dadlez M, Stepinski J, Augustyniak W, Gingras AC, Zhang Z, Burley SK, Sonenberg N, Stolarski R, Darzynkiewicz E. Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein. Rna (New York, N.Y.). 9: 52-61. PMID 12554876 DOI: 10.1261/Rna.2133403  0.605
2003 Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NH. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Molecular and Cellular Biology. 23: 26-37. PMID 12482958 DOI: 10.1128/Mcb.23.1.26-37.2003  0.45
2002 Wang H, Iacoangeli A, Popp S, Muslimov IA, Imataka H, Sonenberg N, Lomakin IB, Tiedge H. Dendritic BC1 RNA: functional role in regulation of translation initiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10232-41. PMID 12451124 DOI: 10.1523/Jneurosci.22-23-10232.2002  0.442
2002 Senthil D, Choudhury GG, Abboud HE, Sonenberg N, Kasinath BS. Regulation of protein synthesis by IGF-I in proximal tubular epithelial cells. American Journal of Physiology. Renal Physiology. 283: F1226-36. PMID 12388420 DOI: 10.1152/Ajprenal.00109.2002  0.478
2002 Uchida N, Hoshino S, Imataka H, Sonenberg N, Katada T. A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation. The Journal of Biological Chemistry. 277: 50286-92. PMID 12381739 DOI: 10.1074/Jbc.M203029200  0.45
2002 Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Molecular and Cellular Biology. 22: 7405-16. PMID 12370288 DOI: 10.1128/Mcb.22.21.7405-7416.2002  0.412
2002 Niedzwiecka A, Stepinski J, Darzynkiewicz E, Sonenberg N, Stolarski R. Positive heat capacity change upon specific binding of translation initiation factor eIF4E to mRNA 5' cap. Biochemistry. 41: 12140-8. PMID 12356315 DOI: 10.1021/Bi0258142  0.363
2002 Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N. Activation of GCN2 in UV-irradiated cells inhibits translation. Current Biology : Cb. 12: 1279-86. PMID 12176355 DOI: 10.1016/S0960-9822(02)01037-0  0.698
2002 West N, Roy-Engel AM, Imataka H, Sonenberg N, Deininger P. Shared protein components of SINE RNPs. Journal of Molecular Biology. 321: 423-32. PMID 12162956 DOI: 10.1016/S0022-2836(02)00542-9  0.389
2002 Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM. A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. The Journal of Clinical Investigation. 110: 119-26. PMID 12093895 DOI: 10.1172/Jci15336  0.379
2002 Niedzwiecka A, Marcotrigiano J, Stepinski J, Jankowska-Anyszka M, Wyslouch-Cieszynska A, Dadlez M, Gingras AC, Mak P, Darzynkiewicz E, Sonenberg N, Burley SK, Stolarski R. Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. Journal of Molecular Biology. 319: 615-35. PMID 12054859 DOI: 10.1016/S0022-2836(02)00328-5  0.571
2002 Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N. Paip1 interacts with poly(A) binding protein through two independent binding motifs. Molecular and Cellular Biology. 22: 3769-82. PMID 11997512 DOI: 10.1128/Mcb.22.11.3769-3782.2002  0.821
2002 Li S, Sonenberg N, Gingras AC, Peterson M, Avdulov S, Polunovsky VA, Bitterman PB. Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency. Molecular and Cellular Biology. 22: 2853-61. PMID 11909977 DOI: 10.1128/Mcb.22.8.2853-2861.2002  0.595
2002 Lachance PE, Miron M, Raught B, Sonenberg N, Lasko P. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Molecular and Cellular Biology. 22: 1656-63. PMID 11865045 DOI: 10.1128/Mcb.22.6.1656-1663.2002  0.64
2002 Maeshima Y, Sudhakar A, Lively JC, Ueki K, Kharbanda S, Kahn CR, Sonenberg N, Hynes RO, Kalluri R. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (New York, N.Y.). 295: 140-3. PMID 11778052 DOI: 10.1126/Science.1065298  0.321
2002 Tang SJ, Reis G, Kang H, Gingras AC, Sonenberg N, Schuman EM. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 99: 467-72. PMID 11756682 DOI: 10.1073/pnas.012605299  0.517
2002 Niedzwiecka A, Marcotrigiano J, Stepinski J, Jankowska-Anyszka M, Wyslouch-Cieszynska A, Dadlez M, Gingras A-, Mak P, Darzynkiewicz E, Sonenberg N. Cocrystal Structure of the Messenger RNA 5' Cap-binding Protein (eIF4E) bound to 7-methylGpppG Cell. 89: 951-961. DOI: 10.2210/Pdb1L8B/Pdb  0.389
2001 Kahvejian A, Roy G, Sonenberg N. The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation. Cold Spring Harbor Symposia On Quantitative Biology. 66: 293-300. PMID 12762031 DOI: 10.1101/Sqb.2001.66.293  0.822
2001 Svitkin YV, Imataka H, Khaleghpour K, Kahvejian A, Liebig HD, Sonenberg N. Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation. Rna (New York, N.Y.). 7: 1743-52. PMID 11780631  0.83
2001 Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, ... ... Sonenberg N, et al. New ways of initiating translation in eukaryotes. Molecular and Cellular Biology. 21: 8238-46. PMID 11710333 DOI: 10.1128/Mcb.21.23.8238-8246.2001  0.521
2001 Hentges KE, Sirry B, Gingeras AC, Sarbassov D, Sonenberg N, Sabatini D, Peterson AS. FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 98: 13796-801. PMID 11707573 DOI: 10.1073/Pnas.241184198  0.39
2001 Miron M, Sonenberg N. Regulation of translation via TOR signaling: insights from Drosophila melanogaster. The Journal of Nutrition. 131: 2988S-93S. PMID 11694634 DOI: 10.1093/Jn/131.11.2988S  0.347
2001 Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, Polakiewicz RD, Wyslouch-Cieszynska A, Aebersold R, Sonenberg N. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes & Development. 15: 2852-64. PMID 11691836 DOI: 10.1101/Gad.912401  0.752
2001 Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML, Sonenberg N. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nature Medicine. 7: 1128-32. PMID 11590436 DOI: 10.1038/Nm1001-1128  0.723
2001 Gingras AC, Raught B, Sonenberg N. Control of translation by the target of rapamycin proteins. Progress in Molecular and Subcellular Biology. 27: 143-74. PMID 11575159 DOI: 10.1007/978-3-662-09889-9_6  0.738
2001 Evdokimova V, Ruzanov P, Imataka H, Raught B, Svitkin Y, Ovchinnikov LP, Sonenberg N. The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer. The Embo Journal. 20: 5491-502. PMID 11574481 DOI: 10.1093/Emboj/20.19.5491  0.644
2001 Mazumder B, Seshadri V, Imataka H, Sonenberg N, Fox PL. Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G. Molecular and Cellular Biology. 21: 6440-9. PMID 11533233 DOI: 10.1128/Mcb.21.19.6440-6449.2001  0.492
2001 Pyronnet S, Dostie J, Sonenberg N. Suppression of cap-dependent translation in mitosis. Genes & Development. 15: 2083-93. PMID 11511540 DOI: 10.1101/Gad.889201  0.744
2001 Sonenberg N, Newgard CB. Protein synthesis. The perks of balancing glucose. Science (New York, N.Y.). 293: 818-9. PMID 11486079 DOI: 10.1126/Science.1062937  0.348
2001 Khaleghpour K, Kahvejian A, De Crescenzo G, Roy G, Svitkin YV, Imataka H, O'Connor-McCourt M, Sonenberg N. Dual interactions of the translational repressor Paip2 with poly(A) binding protein. Molecular and Cellular Biology. 21: 5200-13. PMID 11438674 DOI: 10.1128/Mcb.21.15.5200-5213.2001  0.823
2001 Raught B, Gingras AC, Sonenberg N. The target of rapamycin (TOR) proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 7037-44. PMID 11416184 DOI: 10.1073/Pnas.121145898  0.697
2001 Cormier P, Pyronnet S, Morales J, Mulner-Lorillon O, Sonenberg N, Bellé R. eIF4E association with 4E-BP decreases rapidly following fertilization in sea urchin. Developmental Biology. 232: 275-83. PMID 11401391 DOI: 10.1006/Dbio.2001.0206  0.46
2001 Miron M, Verdú J, Lachance PE, Birnbaum MJ, Lasko PF, Sonenberg N. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nature Cell Biology. 3: 596-601. PMID 11389445 DOI: 10.1038/35078571  0.436
2001 Svitkin YV, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham GJ, Sonenberg N. The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. Rna (New York, N.Y.). 7: 382-94. PMID 11333019 DOI: 10.1017/S135583820100108X  0.449
2001 Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes & Development. 15: 807-26. PMID 11297505 DOI: 10.1101/Gad.887201  0.695
2001 Deo RC, Sonenberg N, Burley SK. X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 98: 4414-9. PMID 11287654 DOI: 10.1073/Pnas.071552198  0.42
2001 Bhandari BK, Feliers D, Duraisamy S, Stewart JL, Gingras AC, Abboud HE, Choudhury GG, Sonenberg N, Kasinath BS. Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells. Kidney International. 59: 866-75. PMID 11231341 DOI: 10.1046/J.1523-1755.2001.059003866.X  0.538
2001 Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N. Translational repression by a novel partner of human poly(A) binding protein, Paip2. Molecular Cell. 7: 205-16. PMID 11172725 DOI: 10.1016/S1097-2765(01)00168-X  0.844
2001 Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Molecular Cell. 7: 193-203. PMID 11172724 DOI: 10.1016/S1097-2765(01)00167-8  0.365
2000 Marissen WE, Gradi A, Sonenberg N, Lloyd RE. Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis. Cell Death and Differentiation. 7: 1234-43. PMID 11175261 DOI: 10.1038/sj.cdd.4400750  0.802
2000 Holcik M, Sonenberg N, Korneluk RG. Internal ribosome initiation of translation and the control of cell death. Trends in Genetics : Tig. 16: 469-73. PMID 11050335 DOI: 10.1016/S0168-9525(00)02106-5  0.436
2000 Stojdl DF, Abraham N, Knowles S, Marius R, Brasey A, Lichty BD, Brown EG, Sonenberg N, Bell JC. The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus. Journal of Virology. 74: 9580-5. PMID 11000229 DOI: 10.1128/Jvi.74.20.9580-9585.2000  0.301
2000 Wakiyama M, Imataka H, Sonenberg N. Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation. Current Biology : Cb. 10: 1147-50. PMID 10996799 DOI: 10.1016/S0960-9822(00)00701-6  0.478
2000 Pyronnet S, Pradayrol L, Sonenberg N. A cell cycle-dependent internal ribosome entry site. Molecular Cell. 5: 607-16. PMID 10882097 DOI: 10.1016/S1097-2765(00)80240-3  0.428
2000 Belsham GJ, Sonenberg N. Picornavirus RNA translation: roles for cellular proteins. Trends in Microbiology. 8: 330-5. PMID 10878768 DOI: 10.1016/S0966-842X(00)01788-1  0.41
2000 Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. The Embo Journal. 19: 3142-56. PMID 10856257 DOI: 10.1093/Emboj/19.12.3142  0.729
2000 Cosentino GP, Schmelzle T, Haghighat A, Helliwell SB, Hall MN, Sonenberg N. Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Molecular and Cellular Biology. 20: 4604-13. PMID 10848587 DOI: 10.1128/Mcb.20.13.4604-4613.2000  0.846
2000 Polunovsky VA, Gingras AC, Sonenberg N, Peterson M, Tan A, Rubins JB, Manivel JC, Bitterman PB. Translational control of the antiapoptotic function of Ras. The Journal of Biological Chemistry. 275: 24776-80. PMID 10811643 DOI: 10.1074/Jbc.M001938200  0.497
2000 Gregorieff A, Pyronnet S, Sonenberg N, Veillette A. Regulation of SOCS-1 expression by translational repression. The Journal of Biological Chemistry. 275: 21596-604. PMID 10764816 DOI: 10.1074/Jbc.M910087199  0.4
2000 Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. The Journal of Biological Chemistry. 275: 10779-87. PMID 10753870 DOI: 10.1074/Jbc.275.15.10779  0.54
2000 Tan A, Bitterman P, Sonenberg N, Peterson M, Polunovsky V. Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1. Oncogene. 19: 1437-47. PMID 10723135 DOI: 10.1038/Sj.Onc.1203446  0.327
2000 Raught B, Gingras AC, Gygi SP, Imataka H, Morino S, Gradi A, Aebersold R, Sonenberg N. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. The Embo Journal. 19: 434-44. PMID 10654941 DOI: 10.1093/Emboj/19.3.434  0.808
2000 Goldstaub D, Gradi A, Bercovitch Z, Grosmann Z, Nophar Y, Luria S, Sonenberg N, Kahana C. Poliovirus 2A protease induces apoptotic cell death. Molecular and Cellular Biology. 20: 1271-7. PMID 10648613 DOI: 10.1128/Mcb.20.4.1271-1277.2000  0.795
2000 Dostie J, Lejbkowicz F, Sonenberg N. Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles. The Journal of Cell Biology. 148: 239-47. PMID 10648556 DOI: 10.1083/Jcb.148.2.239  0.723
2000 Morino S, Imataka H, Svitkin YV, Pestova TV, Sonenberg N. Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Molecular and Cellular Biology. 20: 468-77. PMID 10611225 DOI: 10.1128/Mcb.20.2.468-477.2000  0.425
2000 Taha C, Liu Z, Jin J, Al-Hasani H, Sonenberg N, Klip A. Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation. The Journal of Biological Chemistry. 274: 33085-91. PMID 10551878 DOI: 10.1074/Jbc.274.46.33085  0.435
2000 Raught B, Gingras A, Sonenberg N. 6 Regulation of Ribosomal Recruitment in Eukaryotes Cold Spring Harbor Monograph Archive. 39: 245-293. DOI: 10.1101/087969618.39.245  0.73
2000 Pyronnet S, Pradayrol L, Sonenberg N. A cell cycle-dependent internal ribosome entry site Biochemical Society Transactions. 28: A369-A369. DOI: 10.1042/Bst028A369A  0.3
1999 Gingras AC, Raught B, Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annual Review of Biochemistry. 68: 913-63. PMID 10872469 DOI: 10.1146/Annurev.Biochem.68.1.913  0.753
1999 Li Q, Imataka H, Morino S, Rogers GW, Richter-Cook NJ, Merrick WC, Sonenberg N. Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII Molecular and Cellular Biology. 19: 7336-7346. PMID 10523622 DOI: 10.1128/Mcb.19.11.7336  0.429
1999 Deo RC, Bonanno JB, Sonenberg N, Burley SK. Recognition of polyadenylate RNA by the poly(A)-binding protein Cell. 98: 835-845. PMID 10499800 DOI: 10.1016/S0092-8674(00)81517-2  0.332
1999 Takata M, Ogawa W, Kitamura T, Hino Y, Kuroda S, Kotani K, Klip A, Gingras AC, Sonenberg N, Kasuga M. Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1). The Journal of Biological Chemistry. 274: 20611-8. PMID 10400692 DOI: 10.1074/Jbc.274.29.20611  0.51
1999 Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Molecular Cell. 3: 707-16. PMID 10394359 DOI: 10.1016/S1097-2765(01)80003-4  0.565
1999 Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes & Development. 13: 1422-37. PMID 10364159 DOI: 10.1101/Gad.13.11.1422  0.739
1999 Khaleghpour K, Pyronnet S, Gingras AC, Sonenberg N. Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities. Molecular and Cellular Biology. 19: 4302-10. PMID 10330171 DOI: 10.1128/Mcb.19.6.4302  0.837
1999 Rao GN, Madamanchi NR, Lele M, Gadiparthi L, Gingras AC, Eling TE, Sonenberg N. A potential role for extracellular signal-regulated kinases in prostaglandin F2alpha-induced protein synthesis in smooth muscle cells. The Journal of Biological Chemistry. 274: 12925-32. PMID 10212283 DOI: 10.1074/Jbc.274.18.12925  0.57
1999 Gygi SP, Han DK, Gingras AC, Sonenberg N, Aebersold R. Protein analysis by mass spectrometry and sequence database searching: tools for cancer research in the post-genomic era. Electrophoresis. 20: 310-9. PMID 10197438 DOI: 10.1002/(Sici)1522-2683(19990201)20:2<310::Aid-Elps310>3.0.Co;2-M  0.615
1999 Donzé O, Dostie J, Sonenberg N. Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression. Virology. 256: 322-9. PMID 10191197 DOI: 10.1006/Viro.1999.9618  0.672
1999 Svitkin YV, Gradi A, Imataka H, Morino S, Sonenberg N. Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection. Journal of Virology. 73: 3467-72. PMID 10074204 DOI: 10.1128/Jvi.73.4.3467-3472.1999  0.794
1999 Abraham N, Stojdl DF, Duncan PI, Méthot N, Ishii T, Dubé M, Vanderhyden BC, Atkins HL, Gray DA, McBurney MW, Koromilas AE, Brown EG, Sonenberg N, Bell JC. Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR Journal of Biological Chemistry. 274: 5953-5962. PMID 10026221 DOI: 10.1074/Jbc.274.9.5953  0.369
1999 Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. The Embo Journal. 18: 270-9. PMID 9878069 DOI: 10.1093/Emboj/18.1.270  0.628
1999 Dostie J, Lejbkowicz F, Sonenberg N. eIF4E interacts with a shuttling protein Biochemistry and Cell Biology. 77: 391. DOI: 10.1139/O99-903G  0.668
1998 Imataka H, Gradi A, Sonenberg N. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. The Embo Journal. 17: 7480-9. PMID 9857202 DOI: 10.1093/Emboj/17.24.7480  0.808
1998 Gradi A, Svitkin YV, Imataka H, Sonenberg N. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proceedings of the National Academy of Sciences of the United States of America. 95: 11089-94. PMID 9736694 DOI: 10.1073/Pnas.95.19.11089  0.809
1998 Polakiewicz RD, Schieferl SM, Gingras AC, Sonenberg N, Comb MJ. mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control. The Journal of Biological Chemistry. 273: 23534-41. PMID 9722592 DOI: 10.1074/Jbc.273.36.23534  0.53
1998 Svitkin YV, Hahn H, Gingras AC, Palmenberg AC, Sonenberg N. Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus. Journal of Virology. 72: 5811-9. PMID 9621041 DOI: 10.1128/Jvi.72.7.5811-5819.1998  0.567
1998 Pyronnet S, Gingras AC, Bouisson M, Kowalski-Chauvel A, Seva C, Vaysse N, Sonenberg N, Pradayrol L. Gastrin induces phosphorylation of eIF4E binding protein 1 and translation initiation of ornithine decarboxylase mRNA. Oncogene. 16: 2219-27. PMID 9619831 DOI: 10.1038/Sj.Onc.1201748  0.661
1998 Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. The Journal of Biological Chemistry. 273: 14002-7. PMID 9593750 DOI: 10.1074/Jbc.273.22.14002  0.731
1998 Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK, Sonenberg N. Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. The Journal of Biological Chemistry. 273: 13104-9. PMID 9582349 DOI: 10.1074/Jbc.273.21.13104  0.637
1998 Sonenberg N, Gingras AC. The mRNA 5' cap-binding protein eIF4E and control of cell growth. Current Opinion in Cell Biology. 10: 268-75. PMID 9561852 DOI: 10.1016/S0955-0674(98)80150-6  0.607
1998 Craig AW, Haghighat A, Yu AT, Sonenberg N. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature. 392: 520-3. PMID 9548260 DOI: 10.1038/33198  0.379
1998 Sonenberg N, Burley SK, Gingras AC. RNA chiropractics. Nature Structural Biology. 5: 172-4. PMID 9501904 DOI: 10.1038/nsb0398-172  0.393
1998 Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway Genes and Development. 12: 502-513. PMID 9472019 DOI: 10.1101/Gad.12.4.502  0.384
1998 Fletcher CM, McGuire AM, Gingras AC, Li H, Matsuo H, Sonenberg N, Wagner G. 4E binding proteins inhibit the translation factor eIF4E without folded structure. Biochemistry. 37: 9-15. PMID 9453748 DOI: 10.1021/Bi972494R  0.444
1998 Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N. A novel functional human eukaryotic translation initiation factor 4G. Molecular and Cellular Biology. 18: 334-42. PMID 9418880 DOI: 10.1128/Mcb.18.1.334  0.822
1997 Imataka H, Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Molecular and Cellular Biology. 17: 6940-7. PMID 9372926 DOI: 10.1128/Mcb.17.12.6940  0.38
1997 Gingras AC, Sonenberg N. Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2. Virology. 237: 182-6. PMID 9344920 DOI: 10.1006/Viro.1997.8757  0.563
1997 Matsuo H, Li H, McGuire AM, Fletcher CM, Gingras AC, Sonenberg N, Wagner G. Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nature Structural Biology. 4: 717-24. PMID 9302999 DOI: 10.1038/nsb0997-717  0.532
1997 von Manteuffel SR, Dennis PB, Pullen N, Gingras AC, Sonenberg N, Thomas G. The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Molecular and Cellular Biology. 17: 5426-36. PMID 9271419 DOI: 10.1128/Mcb.17.9.5426  0.397
1997 Haghighat A, Sonenberg N. eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure. The Journal of Biological Chemistry. 272: 21677-80. PMID 9268293 DOI: 10.1074/Jbc.272.35.21677  0.464
1997 Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK. Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell. 89: 951-61. PMID 9200613 DOI: 10.1016/S0092-8674(00)80280-9  0.563
1997 Merrick WC, Sonenberg N. Assays for eukaryotic translation factors that bind mRNA Methods: a Companion to Methods in Enzymology. 11: 333-342. PMID 9126548 DOI: 10.1006/Meth.1996.0431  0.44
1997 Imataka H, Olsen HS, Sonenberg N. A new translational regulator with homology to eukaryotic translation initiation factor 4G Embo Journal. 16: 817-825. PMID 9049310 DOI: 10.1093/Emboj/16.4.817  0.473
1997 Fleurent M, Gingras AC, Sonenberg N, Meloche S. Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanism. The Journal of Biological Chemistry. 272: 4006-12. PMID 9020107 DOI: 10.1074/Jbc.272.7.4006  0.57
1997 Nagai K, Wong AH, Li S, Tam WN, Cuddihy AR, Sonenberg N, Mathews MB, Hiscott J, Wainberg MA, Koromilas AE. Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR. Journal of Virology. 71: 1718-25. PMID 8995707 DOI: 10.1128/Jvi.71.2.1718-1725.1997  0.33
1997 Méthot N, Rom E, Olsen H, Sonenberg N. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. The Journal of Biological Chemistry. 272: 1110-6. PMID 8995410 DOI: 10.1074/Jbc.272.2.1110  0.37
1997 Tsukiyama-Kohara K, Vidal SM, Gingras AC, Glover TW, Hanash SM, Heng H, Sonenberg N. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Genomics. 38: 353-63. PMID 8975712 DOI: 10.1006/Geno.1996.0638  0.34
1997 Craig AW, Svitkin YV, Lee HS, Belsham GJ, Sonenberg N. The La autoantigen contains a dimerization domain that is essential for enhancing translation. Molecular and Cellular Biology. 17: 163-9. PMID 8972196 DOI: 10.1128/Mcb.17.1.163  0.414
1997 Beretta L, Svitkin YV, Sonenberg N. Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection. Journal of Virology. 70: 8993-6. PMID 8971030 DOI: 10.1128/Jvi.70.12.8993-8996.1996  0.467
1997 Haghighat A, Svitkin Y, Novoa I, Kuechler E, Skern T, Sonenberg N. The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. Journal of Virology. 70: 8444-50. PMID 8970966 DOI: 10.1128/Jvi.70.12.8444-8450.1996  0.39
1996 Clark BFC, Grunberg-Manago M, Gupta NK, Hershey JWB, Hinnebusch AG, Jackson RJ, Maitra U, Mathews MB, Merrick WC, Rhoads RE, Sonenberg N, Spremulli LL, Trachsel H, Voorma HO. Prokaryotic and eukaryotic translation factors Biochimie. 78: 1119-1122. PMID 9150893 DOI: 10.1016/S0300-9084(97)86738-7  0.33
1996 Svitkin YV, Ovchinnikov LP, Dreyfuss G, Sonenberg N. General RNA binding proteins render translation cap dependent. The Embo Journal. 15: 7147-55. PMID 9003790 DOI: 10.1002/J.1460-2075.1996.Tb01106.X  0.504
1996 Méthot N, Song MS, Sonenberg N. A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3. Molecular and Cellular Biology. 16: 5328-34. PMID 8816444 DOI: 10.1128/Mcb.16.10.5328  0.473
1996 Raveh T, Hovanessian AG, Meurs EF, Sonenberg N, Kimchi A. Double-stranded RNA-dependent protein kinase mediates c-Myc suppression induced by type I interferons. The Journal of Biological Chemistry. 271: 25479-84. PMID 8810318 DOI: 10.1074/Jbc.271.41.25479  0.354
1996 Craig AW, Cosentino GP, Donzé O, Sonenberg N. The kinase insert domain of interferon-induced protein kinase PKR is required for activity but not for interaction with the pseudosubstrate K3L. The Journal of Biological Chemistry. 271: 24526-33. PMID 8798713 DOI: 10.1074/Jbc.271.40.24526  0.794
1996 Lavoie CA, Lachance PE, Sonenberg N, Lasko P. Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins. The Journal of Biological Chemistry. 271: 16393-8. PMID 8663200 DOI: 10.1074/Jbc.271.27.16393  0.478
1996 Whalen SG, Gingras AC, Amankwa L, Mader S, Branton PE, Aebersold R, Sonenberg N. Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressers, 4E-binding proteins Journal of Biological Chemistry. 271: 11831-11837. PMID 8662663 DOI: 10.1074/Jbc.271.20.11831  0.655
1996 Gingras AC, Svitkin Y, Belsham GJ, Pause A, Sonenberg N. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proceedings of the National Academy of Sciences of the United States of America. 93: 5578-83. PMID 8643618 DOI: 10.1073/Pnas.93.11.5578  0.611
1996 Rousseau D, Kaspar R, Rosenwald I, Gehrke L, Sonenberg N. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E Proceedings of the National Academy of Sciences of the United States of America. 93: 1065-1070. PMID 8577715 DOI: 10.1073/Pnas.93.3.1065  0.447
1996 Belsham GJ, Sonenberg N. RNA-protein interactions in regulation of picornavirus RNA translation. Microbiological Reviews. 60: 499-511. DOI: 10.1128/Mmbr.60.3.499-511.1996  0.442
1996 Sonenberg N. 8 mRNA 5′ Cap-binding Protein elF4E and Control of Cell Growth Cold Spring Harbor Monograph Archive. 30: 245-269. DOI: 10.1101/087969458.30.245  0.414
1996 Mathews MB, Sonenberg N, Hershey JWB. 1 Origins and Targets of Translational Control Cold Spring Harbor Monograph Archive. 30: 1-29. DOI: 10.1101/087969458.30.1  0.447
1996 ROUSSEAU D, GINGRAS A, PAUSE A, SONENBERG N. IDENTIFICATION OF POTENTIAL ANTI-ONCOGENIC PROPERTIES OF elF-4E BINDING PROTEINS 1 AND 2 Biology of the Cell. 88: 69-69. DOI: 10.1016/S0248-4900(97)86843-8  0.545
1996 Svitkin YV, Ovchinnikov LP, Dreyfuss G, Sonenberg N. General RNA binding proteins render translation cap dependent. The Embo Journal. 15: 7147-7155. DOI: 10.1002/j.1460-2075.1996.tb01106.x  0.307
1996 Beretta L, Gingras AC, Svitkin YV, Hall MN, Sonenberg N. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. The Embo Journal. 15: 658-664. DOI: 10.1002/J.1460-2075.1996.Tb00398.X  0.469
1995 Haghighat A, Mader S, Pause A, Sonenberg N. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. The Embo Journal. 14: 5701-9. PMID 8521827 DOI: 10.1002/J.1460-2075.1995.Tb00257.X  0.473
1995 Sonenberg N. Regulation of translation and cell growth by eIF-4E. Biochimie. 76: 839-46. PMID 7880900 DOI: 10.1016/0300-9084(94)90185-6  0.474
1995 Edery I, Chu LL, Sonenberg N, Pelletier J. An efficient strategy to isolate full-length cDNAs based on an mRNA cap retention procedure (CAPture). Molecular and Cellular Biology. 15: 3363-71. PMID 7760832 DOI: 10.1128/Mcb.15.6.3363  0.677
1995 Masison DC, Blanc A, Ribas JC, Carroll K, Sonenberg N, Wickner RB. Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system Molecular and Cellular Biology. 15: 2763-2771. PMID 7739557 DOI: 10.1128/Mcb.15.5.2763  0.303
1995 Silveira Carneiro J, Equestre M, Pagnotti P, Gradi A, Sonenberg N, Perez Bercoff R. 5' UTR of hepatitis A virus RNA: mutations in the 5'-most pyrimidine-rich tract reduce its ability to direct internal initiation of translation. The Journal of General Virology. 76: 1189-96. PMID 7730803 DOI: 10.1099/0022-1317-76-5-1189  0.783
1995 Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV, Sonenberg N, London IM. Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. The Journal of Biological Chemistry. 270: 21176-80. PMID 7673150 DOI: 10.1074/Jbc.270.36.21176  0.406
1995 Mader S, Lee H, Pause A, Sonenberg N. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Molecular and Cellular Biology. 15: 4990-7. PMID 7651417 DOI: 10.1128/Mcb.15.9.4990  0.445
1995 Mader S, Sonenberg N. Cap binding complexes and cellular growth control. Biochimie. 77: 40-4. PMID 7599274 DOI: 10.1016/0300-9084(96)88102-8  0.414
1995 Koromilas AE, Cantin C, Craig AW, Jagus R, Hiscott J, Sonenberg N. The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene. The Journal of Biological Chemistry. 270: 25426-34. PMID 7592710 DOI: 10.1074/Jbc.270.43.25426  0.405
1995 Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N. Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. Proceedings of the National Academy of Sciences of the United States of America. 92: 9445-9. PMID 7568151 DOI: 10.1073/Pnas.92.21.9445  0.821
1995 Belsham GJ, Sonenberg N, Svitkin YV. The role of the La autoantigen in internal initiation. Current Topics in Microbiology and Immunology. 203: 85-98. PMID 7555092 DOI: 10.1007/978-3-642-79663-0_4  0.386
1995 Donzé O, Jagus R, Koromilas AE, Hershey JW, Sonenberg N. Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. The Embo Journal. 14: 3828-3834. DOI: 10.1002/J.1460-2075.1995.Tb00052.X  0.329
1994 Le SY, Sonenberg N, Maizel JV. Distinct structural elements and internal entry of ribosomes in mRNA3 encoded by infectious bronchitis virus. Virology. 198: 405-11. PMID 8259681 DOI: 10.1006/Viro.1994.1051  0.419
1994 Blanc A, Ribas JC, Wickner RB, Sonenberg N. His-154 is involved in the linkage of the Saccharomyces cerevisiae L-A double-stranded RNA virus Gag protein to the cap structure of mRNAs and is essential for M1 satellite virus expression Molecular and Cellular Biology. 14: 2664-2674. PMID 8139566 DOI: 10.1128/Mcb.14.4.2664  0.359
1994 Méthot N, Pause A, Hershey JW, Sonenberg N. The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence. Molecular and Cellular Biology. 14: 2307-16. PMID 8139536 DOI: 10.1128/Mcb.14.4.2307  0.375
1994 Pause A, Méthot N, Svitkin Y, Merrick WC, Sonenberg N. Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. The Embo Journal. 13: 1205-15. PMID 8131750 DOI: 10.1002/J.1460-2075.1994.Tb06370.X  0.396
1994 Svitkin YV, Meerovitch K, Lee HS, Dholakia JN, Kenan DJ, Agol VI, Sonenberg N. Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro. Journal of Virology. 68: 1544-50. PMID 8107217 DOI: 10.1128/Jvi.68.3.1544-1550.1994  0.421
1994 Sonenberg N. mRNA translation: influence of the 5' and 3' untranslated regions. Current Opinion in Genetics & Development. 4: 310-5. PMID 8032210 DOI: 10.1016/S0959-437X(05)80059-0  0.46
1994 Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N, Lawrence JC. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science (New York, N.Y.). 266: 653-6. PMID 7939721 DOI: 10.1126/Science.7939721  0.412
1994 Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature. 371: 762-7. PMID 7935836 DOI: 10.1038/371762A0  0.61
1994 Svitkin YV, Pause A, Sonenberg N. La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA. Journal of Virology. 68: 7001-7. PMID 7933082 DOI: 10.1128/Jvi.68.11.7001-7007.1994  0.448
1994 Sonenberg N. Translation factors as effectors of cell growth and tumorigenesis. Current Opinion in Cell Biology. 5: 955-60. PMID 7907492 DOI: 10.1016/0955-0674(93)90076-3  0.34
1993 Boal TR, Chiorini JA, Cohen RB, Miyamoto S, Frederickson RM, Sonenberg N, Safer B. Regulation of eukaryotic translation initiation factor expression during T-cell activation Bba - Molecular Cell Research. 1176: 257-264. PMID 8471627 DOI: 10.1016/0167-4889(93)90053-R  0.379
1993 Barnett RW, Delling U, Kuperman R, Sonenberg N, Sumner-Smith M. Rotational symmetry in ribonucleotide strand requirements for binding of HIV-1 Tat protein to TAR RNA. Nucleic Acids Research. 21: 151-4. PMID 8441609 DOI: 10.1093/Nar/21.1.151  0.375
1993 Pause A, Méthot N, Sonenberg N. The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Molecular and Cellular Biology. 13: 6789-98. PMID 8413273 DOI: 10.1128/Mcb.13.11.6789  0.364
1993 Meerovitch K, Svitkin YV, Lee HS, Lejbkowicz F, Kenan DJ, Chan EK, Agol VI, Keene JD, Sonenberg N. La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. Journal of Virology. 67: 3798-807. PMID 8389906 DOI: 10.1128/Jvi.67.7.3798-3807.1993  0.419
1993 Le SY, Chen JH, Sonenberg N, Maizel JV. Conserved tertiary structural elements in the 5' nontranslated region of cardiovirus, aphthovirus and hepatitis A virus RNAs. Nucleic Acids Research. 21: 2445-51. PMID 8389442 DOI: 10.1093/Nar/21.10.2445  0.306
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