John R. Traynor - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Opiod signal transductions, addiction
Website:
http://sitemaker.umich.edu/traynor.lab/home

217 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Henry S, Fernandez TM, Anand JP, Griggs N, Traynor JR, Mosberg HI. Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic µ-Opioid-Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability  . Journal of Medicinal Chemistry. PMID 30924650 DOI: 10.1021/acs.jmedchem.9b00219  0.76
2019 Nastase AF, Anand JP, Bender AM, Montgomery D, Griggs N, Fernandez TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. Journal of Medicinal Chemistry. PMID 30916966 DOI: 10.1021/acs.jmedchem.9b00378  0.76
2019 Stanczyk MA, Livingston KE, Chang L, Weinberg Z, Puthenveedu M, Traynor JR. The delta opioid receptor positive allosteric modulator BMS 986187 is a G protein biased allosteric agonist. British Journal of Pharmacology. PMID 30710458 DOI: 10.1111/bph.14602  0.36
2018 Senese NB, Oginsky M, Neubig RR, Ferrario C, Jutkiewicz EM, Traynor JR. Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein. Neuropharmacology. 141: 296-304. PMID 30189184 DOI: 10.1016/j.neuropharm.2018.09.002  0.52
2018 McPherson KB, Leff ER, Li MH, Meurice C, Tai S, Traynor JR, Ingram SL. Regulators of G protein Signaling (RGS) proteins promote receptor coupling to G protein-coupled inwardly-rectifying potassium (GIRK) channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30150362 DOI: 10.1523/JNEUROSCI.0516-18.2018  0.36
2018 Livingston KE, Mahoney JP, Manglik A, Sunahara R, Traynor JR. Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. Elife. 7. PMID 29932421 DOI: 10.7554/eLife.32499  0.36
2018 Nastase AF, Griggs NW, Anand JP, Fernandez TJ, Harland AA, Trask TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Synthesis and pharmacological evaluation of novel C-8 substituted tetrahydroquinolines as balanced-affinity mu/delta opioid ligands for the treatment of pain. Acs Chemical Neuroscience. PMID 29677442 DOI: 10.1021/acschemneuro.8b00139  0.76
2018 Anand JP, Kochan KE, Nastase AF, Montgomery D, Griggs NW, Traynor JR, Mosberg HI, Jutkiewicz EM. In Vivo Effects of μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Peptidomimetics Following Acute and Repeated Administration. British Journal of Pharmacology. PMID 29352503 DOI: 10.1111/bph.14148  0.76
2017 Dripps IJ, Boyer BT, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. Role of signaling molecules in behaviors mediated by the δ-receptor agonist SNC80. British Journal of Pharmacology. PMID 29278419 DOI: 10.1111/bph.14131  0.52
2017 Livingston KE, Stanczyk MA, Burford N, Alt A, Canals M, Traynor JR. Pharmacological Evidence for a Putative Conserved Allosteric Site on Opioid Receptors. Molecular Pharmacology. PMID 29233847 DOI: 10.1124/mol.117.109561  0.36
2017 Lamberts JT, Rosenthal LD, Jutkiewicz EM, Traynor JR. Role of the guanine nucleotide binding protein, Gαo, in the development of morphine tolerance and dependence. Psychopharmacology. PMID 28971229 DOI: 10.1007/s00213-017-4742-2  1
2017 Harland AA, Pogozheva ID, Griggs NW, Trask TJ, Traynor JR, Mosberg HI. Placement of hydroxy moiety on pendant of peptidomimetic scaffold modulates mu and kappa opioid receptor efficacy. Acs Chemical Neuroscience. PMID 28796483 DOI: 10.1021/acschemneuro.7b00284  0.76
2017 Livingston KE, Traynor JR. Allostery at opioid receptors: modulation with small molecule ligands. British Journal of Pharmacology. PMID 28419415 DOI: 10.1111/bph.13823  0.36
2016 Healy JR, Bezawada P, Griggs NW, Devereaux AL, Matsumoto RR, Traynor JR, Coop A, Cunningham CW. Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28011222 DOI: 10.1016/j.bmcl.2016.11.057  0.52
2016 Dripps IJ, Wang Q, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors. Psychopharmacology. PMID 27624599 DOI: 10.1007/s00213-016-4432-5  0.52
2016 Harland AA, Bender AM, Griggs NW, Gao C, Anand JP, Pogozheva ID, Traynor JR, Jutkiewicz EM, Mosberg HI. Effects of N-Substitutions on the Tetrahydroquinoline (THQ) core of Mixed-Efficacy μ-Opioid Receptor (MOR)/ δ-Opioid Receptor (DOR) Ligands. Journal of Medicinal Chemistry. PMID 27148755 DOI: 10.1021/acs.jmedchem.6b00308  1
2015 Bender AM, Griggs NW, Gao C, Trask TJ, Traynor JR, Mosberg HI. Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics. Acs Medicinal Chemistry Letters. 6: 1199-203. PMID 26713104 DOI: 10.1021/acsmedchemlett.5b00344  1
2015 Yao XQ, Malik R, Griggs NW, Skjaerven L, Traynor JR, Sivaramakrishnan S, Grant BJ. Dynamic coupling and allosteric networks in the alpha subunit of heterotrimeric G proteins. The Journal of Biological Chemistry. PMID 26703464 DOI: 10.1074/jbc.M115.702605  1
2015 Harland AA, Yeomans L, Griggs NW, Anand JP, Pogozheva ID, Jutkiewicz EM, Traynor JR, Mosberg HI. Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/ δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities. Journal of Medicinal Chemistry. PMID 26524472 DOI: 10.1021/acs.jmedchem.5b01270  1
2015 Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor. Journal of Chemical Information and Modeling. PMID 26347990 DOI: 10.1021/acs.jcim.5b00388  1
2015 Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, et al. Structural insights into µ-opioid receptor activation. Nature. 524: 315-21. PMID 26245379 DOI: 10.1038/nature14886  1
2015 Bender AM, Griggs NW, Anand JP, Traynor JR, Jutkiewicz EM, Mosberg HI. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands. Acs Chemical Neuroscience. 6: 1428-35. PMID 25938166 DOI: 10.1021/acschemneuro.5b00100  1
2015 Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, ... Traynor JR, et al. Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor. Journal of Medicinal Chemistry. 58: 4220-9. PMID 25901762 DOI: 10.1021/acs.jmedchem.5b00007  1
2015 Cueva JP, Roche C, Ostovar M, Kumar V, Clark MJ, Hillhouse TM, Lewis JW, Traynor JR, Husbands SM. C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors. Journal of Medicinal Chemistry. 58: 4242-9. PMID 25898137 DOI: 10.1021/acs.jmedchem.5b00130  1
2015 Blazer LL, Storaska AJ, Jutkiewicz EM, Turner EM, Calcagno M, Wade SM, Wang Q, Huang XP, Traynor JR, Husbands SM, Morari M, Neubig RR. Selectivity and Anti-Parkinson's Potential of Thiadiazolidinone RGS4 Inhibitors. Acs Chemical Neuroscience. 6: 911-9. PMID 25844489 DOI: 10.1021/acschemneuro.5b00063  1
2015 Christie MJ, Connor M, Traynor JR. Themed section. British Journal of Pharmacology. 172: 247-50. PMID 25537825 DOI: 10.1111/bph.13028  1
2015 Graves SM, Clark MJ, Traynor JR, Hu XT, Napier TC. Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism. Neuropharmacology. 89: 113-21. PMID 25229719 DOI: 10.1016/j.neuropharm.2014.09.001  1
2015 Cox BM, Christie MJ, Devi L, Toll L, Traynor JR. Challenges for opioid receptor nomenclature: IUPHAR Review 9. British Journal of Pharmacology. 172: 317-23. PMID 24528283 DOI: 10.1111/bph.12612  1
2015 Burford NT, Traynor JR, Alt A. Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications. British Journal of Pharmacology. 172: 277-86. PMID 24460691 DOI: 10.1111/bph.12599  1
2014 Livingston KE, Traynor JR. Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 111: 18369-74. PMID 25489080 DOI: 10.1073/pnas.1415013111  1
2014 Ben Haddou T, Malfacini D, Calo G, Aceto MD, Harris LS, Traynor JR, Coop A, Schmidhammer H, Spetea M. Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor. Molecular Pain. 10: 48. PMID 25059282 DOI: 10.1186/1744-8069-10-48  1
2014 Kumar V, Clark MJ, Traynor JR, Lewis JW, Husbands SM. Pyrrolo- and pyridomorphinans: non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists. Bioorganic & Medicinal Chemistry. 22: 4067-72. PMID 24973818 DOI: 10.1016/j.bmc.2014.05.065  1
2014 Wang Q, Terauchi A, Yee CH, Umemori H, Traynor JR. 5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19. Cellular Signalling. 26: 1846-52. PMID 24793302 DOI: 10.1016/j.cellsig.2014.04.017  1
2014 Kumar V, Ridzwan IE, Grivas K, Lewis JW, Clark MJ, Meurice C, Jimenez-Gomez C, Pogozheva I, Mosberg H, Traynor JR, Husbands SM. Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. Journal of Medicinal Chemistry. 57: 4049-57. PMID 24761755 DOI: 10.1021/jm401964y  1
2014 Mosberg HI, Yeomans L, Anand JP, Porter V, Sobczyk-Kojiro K, Traynor JR, Jutkiewicz EM. Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. Journal of Medicinal Chemistry. 57: 3148-53. PMID 24641190 DOI: 10.1021/jm5002088  1
2014 Anand JP, Porter-Barrus VR, Waldschmidt HV, Yeomans L, Pogozheva ID, Traynor JR, Mosberg HI. Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues. Biopolymers. 102: 107-14. PMID 24436042 DOI: 10.1002/bip.22437  1
2014 Casal-Dominguez JJ, Furkert D, Ostovar M, Teintang L, Clark MJ, Traynor JR, Husbands SM, Bailey SJ. Characterization of BU09059: a novel potent selective κ-receptor antagonist. Acs Chemical Neuroscience. 5: 177-84. PMID 24410326 DOI: 10.1021/cn4001507  1
2014 Bender AM, Clark MJ, Agius MP, Traynor JR, Mosberg HI. Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Bioorganic & Medicinal Chemistry Letters. 24: 548-51. PMID 24365161 DOI: 10.1016/j.bmcl.2013.12.021  1
2014 Bosse KE, Jutkiewicz EM, Schultz-Kuszak KN, Mabrouk OS, Kennedy RT, Gnegy ME, Traynor JR. Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism. Neuropharmacology. 77: 19-27. PMID 24035916 DOI: 10.1016/j.neuropharm.2013.08.027  1
2013 Burford NT, Clark MJ, Wehrman TS, Gerritz SW, Banks M, O'Connell J, Traynor JR, Alt A. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 110: 10830-5. PMID 23754417 DOI: 10.1073/pnas.1300393110  1
2013 Lamberts JT, Smith CE, Li MH, Ingram SL, Neubig RR, Traynor JR. Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4369-77. PMID 23467353 DOI: 10.1523/JNEUROSCI.5470-12.2013  1
2013 Lamberts JT, Traynor JR. Opioid receptor interacting proteins and the control of opioid signaling. Current Pharmaceutical Design. 19: 7333-47. PMID 23448476 DOI: 10.2174/138161281942140105160625  1
2013 Birdsong WT, Arttamangkul S, Clark MJ, Cheng K, Rice KC, Traynor JR, Williams JT. Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4118-27. PMID 23447620 DOI: 10.1523/JNEUROSCI.4187-12.2013  1
2013 Greedy BM, Bradbury F, Thomas MP, Grivas K, Cami-Kobeci G, Archambeau A, Bosse K, Clark MJ, Aceto M, Lewis JW, Traynor JR, Husbands SM. Orvinols with mixed kappa/mu opioid receptor agonist activity. Journal of Medicinal Chemistry. 56: 3207-16. PMID 23438330 DOI: 10.1021/jm301543e  1
2013 Mosberg HI, Yeomans L, Harland AA, Bender AM, Sobczyk-Kojiro K, Anand JP, Clark MJ, Jutkiewicz EM, Traynor JR. Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Journal of Medicinal Chemistry. 56: 2139-49. PMID 23419026 DOI: 10.1021/jm400050y  1
2013 Wang Q, Traynor JR. Modulation of μ-opioid receptor signaling by RGS19 in SH-SY5Y cells. Molecular Pharmacology. 83: 512-20. PMID 23197645 DOI: 10.1124/mol.112.081992  1
2013 Casal-Dominguez JJ, Clark M, Traynor JR, Husbands SM, Bailey SJ. In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor. Journal of Psychopharmacology (Oxford, England). 27: 192-202. PMID 23118019 DOI: 10.1177/0269881112464828  1
2012 Moynihan HA, Derrick I, Broadbear JH, Greedy BM, Aceto MD, Harris LS, Purington LC, Thomas MP, Woods JH, Traynor JR, Husbands SM, Lewis JW. Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversible μ opioid receptor antagonist effects. Journal of Medicinal Chemistry. 55: 9868-74. PMID 23043264 DOI: 10.1021/jm301096s  1
2012 Anand JP, Purington LC, Pogozheva ID, Traynor JR, Mosberg HI. Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models. Chemical Biology & Drug Design. 80: 763-70. PMID 22882801 DOI: 10.1111/cbdd.12014  1
2012 Traynor J. μ-Opioid receptors and regulators of G protein signaling (RGS) proteins: From a symposium on new concepts in mu-opioid pharmacology Drug and Alcohol Dependence. 121: 173-180. PMID 22129844 DOI: 10.1016/j.drugalcdep.2011.10.027  1
2011 Purington LC, Sobczyk-Kojiro K, Pogozheva ID, Traynor JR, Mosberg HI. Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide. Acs Chemical Biology. 6: 1375-81. PMID 21958158 DOI: 10.1021/cb200263q  1
2011 Roman DL, Traynor JR. Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction. Journal of Medicinal Chemistry. 54: 7433-40. PMID 21916427 DOI: 10.1021/jm101572n  1
2011 Lamberts JT, Jutkiewicz EM, Mortensen RM, Traynor JR. μ-Opioid receptor coupling to Gα(o) plays an important role in opioid antinociception. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2041-53. PMID 21654736 DOI: 10.1038/npp.2011.91  1
2011 Peckham EM, Graves SM, Jutkiewicz E, Becker JB, Traynor JR. Role of gonadal hormones on mu-opioid-stimulated [³⁵S]GTPγS binding and morphine-mediated antinociception in male and female Sprague-Dawley rats. Psychopharmacology. 218: 483-92. PMID 21607564 DOI: 10.1007/s00213-011-2335-z  1
2011 Wang Q, Traynor JR. Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk. The Journal of Biological Chemistry. 286: 7854-64. PMID 21209077 DOI: 10.1074/jbc.M110.160911  1
2011 Levitt ES, Purington LC, Traynor JR. Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot. Molecular Pharmacology. 79: 461-71. PMID 21098043 DOI: 10.1124/mol.110.064816  1
2010 Pichika R, Jewett DM, Sherman PS, Traynor JR, Husbands SM, Woods JH, Kilbourn MR. Synthesis and in vivo brain distribution of carbon-11-labeled δ-opioid receptor agonists. Nuclear Medicine and Biology. 37: 989-96. PMID 21055630 DOI: 10.1016/j.nucmedbio.2010.06.002  1
2010 Connor M, Traynor J. Constitutively active μ-opioid receptors. Methods in Enzymology. 484: 445-69. PMID 21036245 DOI: 10.1016/B978-0-12-381298-8.00022-8  1
2010 Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR. RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. 107: 11086-91. PMID 20534514 DOI: 10.1073/pnas.1000003107  1
2010 Traynor J. Regulator of G protein-signaling proteins and addictive drugs Annals of the New York Academy of Sciences. 1187: 341-352. PMID 20201861 DOI: 10.1111/j.1749-6632.2009.05150.x  1
2010 Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR. Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. Journal of Neurochemistry. 112: 1026-34. PMID 20002516 DOI: 10.1111/j.1471-4159.2009.06519.x  1
2009 Nieland NP, Rennison D, Broadbear JH, Purington L, Woods JH, Traynor JR, Lewis JW, Husbands SM. 14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible mu opioid receptor antagonists. Journal of Medicinal Chemistry. 52: 6926-30. PMID 19842669 DOI: 10.1021/jm901074a  1
2009 Purington LC, Pogozheva ID, Traynor JR, Mosberg HI. Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties. Journal of Medicinal Chemistry. 52: 7724-31. PMID 19788201 DOI: 10.1021/jm9007483  1
2009 Ingram SL, Traynor JR. Role of protein kinase C in functional selectivity for desensitization at the mu-opioid receptor: from pharmacological curiosity to therapeutic potential. British Journal of Pharmacology. 158: 154-6. PMID 19719778 DOI: 10.1111/j.1476-5381.2009.00198.x  1
2009 Levitt ES, Clark MJ, Jenkins PM, Martens JR, Traynor JR. Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: a parallel comparison of acute and chronic signaling to adenylyl cyclase. The Journal of Biological Chemistry. 284: 22108-22. PMID 19520863 DOI: 10.1074/jbc.M109.030411  1
2009 Wang Q, Liu-Chen LY, Traynor JR. Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. The Journal of Biological Chemistry. 284: 18357-67. PMID 19416973 DOI: 10.1074/jbc.M109.015453  1
2009 Bradbury FA, Zelnik JC, Traynor JR. G protein independent phosphorylation and internalization of the delta-opioid receptor. Journal of Neurochemistry. 109: 1526-35. PMID 19344370 DOI: 10.1111/j.1471-4159.2009.06082.x  1
2009 Moynihan H, Jales AR, Greedy BM, Rennison D, Broadbear JH, Purington L, Traynor JR, Woods JH, Lewis JW, Husbands SM. 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. Journal of Medicinal Chemistry. 52: 1553-7. PMID 19253983 DOI: 10.1021/jm8012272  1
2009 Cami-Kobeci G, Neal AP, Bradbury FA, Purington LC, Aceto MD, Harris LS, Lewis JW, Traynor JR, Husbands SM. Mixed kappa/mu opioid receptor agonists: the 6 beta-naltrexamines. Journal of Medicinal Chemistry. 52: 1546-52. PMID 19253970 DOI: 10.1021/jm8015552  1
2009 Divin MF, Bradbury FA, Carroll FI, Traynor JR. Neutral antagonist activity of naltrexone and 6beta-naltrexol in naïve and opioid-dependent C6 cells expressing a mu-opioid receptor. British Journal of Pharmacology. 156: 1044-53. PMID 19220294 DOI: 10.1111/j.1476-5381.2008.00035.x  1
2009 Traynor JR, Terzi D, Caldarone BJ, Zachariou V. RGS9-2: probing an intracellular modulator of behavior as a drug target. Trends in Pharmacological Sciences. 30: 105-11. PMID 19211160 DOI: 10.1016/j.tips.2008.11.006  1
2008 Brinkerhoff CJ, Traynor JR, Linderman JJ. Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results? Journal of Theoretical Biology. 255: 278-86. PMID 18761019 DOI: 10.1016/j.jtbi.2008.08.003  1
2008 Bosse KE, Jutkiewicz EM, Gnegy ME, Traynor JR. The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum. Neuropharmacology. 55: 755-62. PMID 18602932 DOI: 10.1016/j.neuropharm.2008.06.017  1
2008 Xie H, Woods JH, Traynor JR, Ko MC. The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies. Anesthesia and Analgesia. 106: 1873-81. PMID 18499626 DOI: 10.1213/ane.0b013e31817300be  1
2008 Cunningham CW, Mercer SL, Hassan HE, Traynor JR, Eddington ND, Coop A. Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. Journal of Medicinal Chemistry. 51: 2316-20. PMID 18311899 DOI: 10.1021/jm701457j  1
2008 Clark MJ, Linderman JJ, Traynor JR. Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model. Molecular Pharmacology. 73: 1538-48. PMID 18285510 DOI: 10.1124/mol.107.043547  1
2008 Divin MF, Holden Ko MC, Traynor JR. Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice. European Journal of Pharmacology. 583: 48-55. PMID 18275956 DOI: 10.1016/j.ejphar.2008.01.004  1
2008 Fantegrossi WE, Ciullo JR, Wakabayashi KT, De La Garza R, Traynor JR, Woods JH. A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse. Neuroscience. 151: 533-43. PMID 18082974 DOI: 10.1016/j.neuroscience.2007.11.007  1
2008 Mercer SL, Shaikh J, Traynor JR, Matsumoto RR, Coop A. Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands. European Journal of Medicinal Chemistry. 43: 1304-8. PMID 17988766 DOI: 10.1016/j.ejmech.2007.09.026  1
2008 Metcalf MD, Aceto MD, Harris LS, Woods JH, Traynor JR, Coop A, May EL. The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans. Bioorganic & Medicinal Chemistry. 16: 869-73. PMID 17962026 DOI: 10.1016/j.bmc.2007.10.030  1
2007 Li Y, Husbands SM, Mahon MF, Traynor JR, Rowan MG. Isolation and chemical modification of clerodane diterpenoids from Salvia species as potential agonists at the kappa-opioid receptor. Chemistry & Biodiversity. 4: 1586-93. PMID 17638340 DOI: 10.1002/cbdv.200790138  1
2007 Li JX, Becker GL, Traynor JR, Gong ZH, France CP. Thienorphine: receptor binding and behavioral effects in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 321: 227-36. PMID 17220427 DOI: 10.1124/jpet.106.113290  1
2007 Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/mol.106.028670  1
2006 Clark MJ, Traynor JR. Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3. Journal of Neurochemistry. 99: 1494-504. PMID 17230639 DOI: 10.1111/j.1471-4159.2006.04176.x  1
2006 Rennison D, Moynihan H, Traynor JR, Lewis JW, Husbands SM. Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring. Journal of Medicinal Chemistry. 49: 6104-10. PMID 17004724 DOI: 10.1021/jm060595u  1
2006 Nieland NP, Moynihan HA, Carrington S, Broadbear J, Woods JH, Traynor JR, Husbands SM, Lewis JW. Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones. Journal of Medicinal Chemistry. 49: 5333-8. PMID 16913723 DOI: 10.1021/jm0604777  1
2006 Lester PA, Traynor JR. Comparison of the in vitro efficacy of mu, delta, kappa and ORL1 receptor agonists and non-selective opioid agonists in dog brain membranes. Brain Research. 1073: 290-6. PMID 16443205 DOI: 10.1016/j.brainres.2005.12.066  1
2006 Clark MJ, Furman CA, Gilson TD, Traynor JR. Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation. The Journal of Pharmacology and Experimental Therapeutics. 317: 858-64. PMID 16436499 DOI: 10.1124/jpet.105.096818  1
2006 Czermak C, Lehofer M, Liebmann PM, Traynor J. [35S]GTPγS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine European Journal of Pharmacology. 531: 20-24. PMID 16423344 DOI: 10.1016/j.ejphar.2005.11.063  1
2006 Peckham EM, Traynor JR. Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 316: 1195-201. PMID 16291875 DOI: 10.1124/jpet.105.094276  1
2006 Ko MC, Divin MF, Lee H, Woods JH, Traynor JR. Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey. The Journal of Pharmacology and Experimental Therapeutics. 316: 772-9. PMID 16258020 DOI: 10.1124/jpet.105.094409  1
2006 González-Núñez V, Barrallo A, Traynor JR, Rodríguez RE. Characterization of opioid-binding sites in zebrafish brain. The Journal of Pharmacology and Experimental Therapeutics. 316: 900-4. PMID 16207834 DOI: 10.1124/jpet.105.093492  1
2005 Przydzial MJ, Pogozheva ID, Ho JC, Bosse KE, Sawyer E, Traynor JR, Mosberg HI. Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 66: 255-62. PMID 16218993 DOI: 10.1111/j.1399-3011.2005.00295.x  1
2005 Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats. Psychopharmacology. 182: 588-96. PMID 16163520 DOI: 10.1007/s00213-005-0138-9  1
2005 Peckham EM, Barkley LM, Divin MF, Cicero TJ, Traynor JR. Comparison of the antinociceptive effect of acute morphine in female and male Sprague-Dawley rats using the long-lasting mu-antagonist methocinnamox. Brain Research. 1058: 137-47. PMID 16139823 DOI: 10.1016/j.brainres.2005.07.060  1
2005 Jutkiewicz EM, Kaminsky ST, Rice KC, Traynor JR, Woods JH. Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 315: 414-22. PMID 16014751 DOI: 10.1124/jpet.105.088831  1
2005 Przydzial MJ, Pogozheva ID, Bosse KE, Andrews SM, Tharp TA, Traynor JR, Mosberg HI. Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the kappa-opioid receptor. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 333-42. PMID 15787963 DOI: 10.1111/j.1399-3011.2005.00220.x  1
2005 Chauvignac C, Miller CN, Srivastava SK, Lewis JW, Husbands SM, Traynor JR. Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist. Journal of Medicinal Chemistry. 48: 1676-9. PMID 15743210 DOI: 10.1021/jm049172n  1
2005 Traynor JR, Neubig RR. Regulators of G protein signaling & drugs of abuse. Molecular Interventions. 5: 30-41. PMID 15734717 DOI: 10.1124/mi.5.1.7  1
2005 Jutkiewicz EM, Walker NP, Folk JE, Rice KC, Portoghese PS, Woods JH, Traynor JR. Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 312: 1314-20. PMID 15574687 DOI: 10.1124/jpet.104.078741  1
2005 Clark MJ, Traynor JR. Endogenous regulator of g protein signaling proteins reduce {mu}-opioid receptor desensitization and down-regulation and adenylyl cyclase tolerance in C6 cells. The Journal of Pharmacology and Experimental Therapeutics. 312: 809-15. PMID 15383633 DOI: 10.1124/jpet.104.074641  1
2004 Srivastava SK, Shefali S, Miller CN, Aceto MD, Traynor JR, Lewis JW, Husbands SM. Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan. Journal of Medicinal Chemistry. 47: 6645-8. PMID 15588100 DOI: 10.1021/jm040817t  1
2004 Neilan CL, Husbands SM, Breeden S, Ko MC, Aceto MD, Lewis JW, Woods JH, Traynor JR. Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist. European Journal of Pharmacology. 499: 107-16. PMID 15363957 DOI: 10.1016/j.ejphar.2004.07.097  1
2004 Clark MJ, Traynor JR. Assays for G-protein-coupled receptor signaling using RGS-insensitive Galpha subunits. Methods in Enzymology. 389: 155-69. PMID 15313565 DOI: 10.1016/S0076-6879(04)89010-4  1
2004 Waller A, Sutton KL, Kinzer-Ursem TL, Absood A, Traynor JR, Linderman JJ, Omann GM. Receptor binding kinetics and cellular responses of six N-formyl peptide agonists in human neutrophils. Biochemistry. 43: 8204-16. PMID 15209517 DOI: 10.1021/bi035335i  1
2004 Romano MA, McNish R, Seymour EM, Traynor JR, Bolling SF. Differential effects of opioid peptides on myocardial ischemic tolerance. The Journal of Surgical Research. 119: 46-50. PMID 15126081 DOI: 10.1016/j.jss.2004.01.006  1
2004 Clark MJ, Neubig RR, Traynor JR. Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization. The Journal of Pharmacology and Experimental Therapeutics. 310: 215-22. PMID 15014136 DOI: 10.1124/jpet.103.064824  1
2004 Jutkiewicz EM, Eller EB, Folk JE, Rice KC, Traynor JR, Woods JH. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 309: 173-81. PMID 14722329 DOI: 10.1124/jpet.103.061242  1
2003 Black SL, Chauvignac C, Grundt P, Miller CN, Wood S, Traynor JR, Lewis JW, Husbands SM. Guanidino N-substituted and N,N-disubstituted derivatives of the kappa-opioid antagonist GNTI. Journal of Medicinal Chemistry. 46: 5505-11. PMID 14640558 DOI: 10.1021/jm0309203  1
2003 Seymour EM, Wu SY, Kovach MA, Romano MA, Traynor JR, Claycomb WC, Bolling SF. HL-1 myocytes exhibit PKC and K(ATP) channel-dependent delta opioid preconditioning. The Journal of Surgical Research. 114: 187-94. PMID 14559445 DOI: 10.1016/S0022-4804(03)00248-8  1
2003 Heyl DL, Schullery SE, Renganathan K, Jayamaha MN, Rodgers DW, Traynor JR. pKa and volume of residue one influence delta/mu opioid binding: QSAR analysis of tyrosine replacement in a nonselective deltorphin analogue. Bioorganic & Medicinal Chemistry. 11: 3761-8. PMID 12901921 DOI: 10.1016/S0968-0896(03)00329-8  1
2003 Greiner E, Spetea M, Krassnig R, Schüllner F, Aceto M, Harris LS, Traynor JR, Woods JH, Coop A, Schmidhammer H. Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships. Journal of Medicinal Chemistry. 46: 1758-63. PMID 12699394 DOI: 10.1021/jm021118o  1
2003 Ko MC, Lee H, Harrison C, Clark MJ, Song HF, Naughton NN, Woods JH, Traynor JR. Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys. The Journal of Pharmacology and Experimental Therapeutics. 306: 179-86. PMID 12676881 DOI: 10.1124/jpet.103.050625  1
2003 Grundt P, Jales AR, Traynor JR, Lewis JW, Husbands SM. 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. Journal of Medicinal Chemistry. 46: 1563-6. PMID 12672258 DOI: 10.1021/jm021073r  1
2003 Clark MJ, Harrison C, Zhong H, Neubig RR, Traynor JR. Endogenous RGS protein action modulates mu-opioid signaling through Galphao. Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways. The Journal of Biological Chemistry. 278: 9418-25. PMID 12524446 DOI: 10.1074/jbc.M208885200  1
2003 May EL, Coop A, Woods JH, Aceto MD, Bowman ER, Harris LS, Traynor JR. N-(trifluoromethyl)benzyl substituted N-normetazocines and N-norketobemidones. Bioorganic & Medicinal Chemistry. 11: 31-3. PMID 12467704 DOI: 10.1016/S0968-0896(02)00435-2  1
2003 Zhong H, Wade SM, Woolf PJ, Linderman JJ, Traynor JR, Neubig RR. A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding. The Journal of Biological Chemistry. 278: 7278-84. PMID 12446706 DOI: 10.1074/jbc.M208819200  1
2003 Harrison C, Traynor JR. The [35S]GTPγS binding assay: Approaches and applications in pharmacology Life Sciences. 74: 489-508. DOI: 10.1016/j.lfs.2003.07.005  1
2002 Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Behavioral effects of delta-opioid receptor agonists: potential antidepressants? Japanese Journal of Pharmacology. 90: 1-6. PMID 12396021 DOI: 10.1254/jjp.90.1  1
2002 Broom DC, Nitsche JF, Pintar JE, Rice KC, Woods JH, Traynor JR. Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 303: 723-9. PMID 12388657 DOI: 10.1124/jpet.102.036525  1
2002 Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH. Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats. Psychopharmacology. 164: 42-8. PMID 12373418 DOI: 10.1007/s00213-002-1179-y  1
2002 Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH. Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 744-55. PMID 12007745 DOI: 10.1016/S0893-133X(01)00413-4  1
2002 Ko MC, Naughton NN, Traynor JR, Song MS, Woods JH, Rice KC, McKnight AT. Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors. British Journal of Pharmacology. 135: 943-50. PMID 11861322 DOI: 10.1038/sj.bjp.0704535  1
2002 Alt A, Clark MJ, Woods JH, Traynor JR. Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells. British Journal of Pharmacology. 135: 217-25. PMID 11786497 DOI: 10.1038/sj.bjp.0704430  1
2002 Srivastava SK, Husbands SM, Aceto MD, Miller CN, Traynor JR, Lewis JW. 4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity. Journal of Medicinal Chemistry. 45: 537-40. PMID 11784158 DOI: 10.1021/jm010841w  1
2002 Traynor JR, Clark MJ, Remmers AE. Relationship between rate and extent of G protein activation: comparison between full and partial opioid agonists. The Journal of Pharmacology and Experimental Therapeutics. 300: 157-61. PMID 11752111 DOI: 10.1124/jpet.300.1.157  1
2001 Butelman ER, Ko MC, Traynor JR, Vivian JA, Kreek MJ, Woods JH. GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 298: 1049-59. PMID 11504802  1
2001 Alt A, McFadyen IJ, Fan CD, Woods JH, Traynor JR. Stimulation of guanosine-5'-o-(3-[35S]thio)triphosphate binding in digitonin-permeabilized C6 rat glioma cells: evidence for an organized association of mu-opioid receptors and G protein. The Journal of Pharmacology and Experimental Therapeutics. 298: 116-21. PMID 11408532  1
2000 May EL, Jacobson AE, Mattson MV, Traynor JR, Woods JH, Harris LS, Bowman ER, Aceto MD. Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. Journal of Medicinal Chemistry. 43: 5030-6. PMID 11150174 DOI: 10.1021/jm000317+  1
2000 Neilan CL, Kenyon E, Kovach MA, Bowden K, Claycomb WC, Traynor JR, Bolling SF. An immortalized myocyte cell line, HL-1, expresses a functional delta -opioid receptor. Journal of Molecular and Cellular Cardiology. 32: 2187-93. PMID 11112994 DOI: 10.1006/jmcc.2000.1241  1
2000 McFadyen IJ, Sobczyk-Kojiro K, Schaefer MJ, Ho JC, Omnaas JR, Mosberg HI, Traynor JR. Tetrapeptide derivatives of [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE) lacking an N-terminal tyrosine residue are agonists at the mu-opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 295: 960-6. PMID 11082429  1
2000 Coop A, Jacobson AE, Aceto MD, Harris LS, Traynor JR, Woods JH, Rice KC. N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. Bioorganic & Medicinal Chemistry Letters. 10: 2449-51. PMID 11078198  1
2000 McFadyen IJ, Houshyar H, Liu-Chen LY, Woods JH, Traynor JR. The steroid 17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3, 5-dien-20-one (SC17599) is a selective mu-opioid agonist: implications for the mu-opioid pharmacophore. Molecular Pharmacology. 58: 669-76. PMID 10999935  1
2000 Derrick I, Neilan CL, Andes J, Husbands SM, Woods JH, Traynor JR, Lewis JW. 3-Deoxyclocinnamox: the first high-affinity, nonpeptide mu-opioid antagonist lacking a phenolic hydroxyl group. Journal of Medicinal Chemistry. 43: 3348-50. PMID 10966754 DOI: 10.1021/jm0009641  1
2000 Broom DC, Guo L, Coop A, Husbands SM, Lewis JW, Woods JH, Traynor JR. BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 294: 1195-200. PMID 10945877  1
2000 Broadbear JH, Sumpter TL, Burke TF, Husbands SM, Lewis JW, Woods JH, Traynor JR. Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine. The Journal of Pharmacology and Experimental Therapeutics. 294: 933-40. PMID 10945843  1
2000 Rodriguez RE, Barrallo A, Garcia-Malvar F, McFadyen IJ, Gonzalez-Sarmiento R, Traynor JR. Characterization of ZFOR1, a putative delta-opioid receptor from the teleost zebrafish (Danio rerio). Neuroscience Letters. 288: 207-10. PMID 10889344 DOI: 10.1016/S0304-3940(00)01239-8  1
2000 Remmers AE, Clark MJ, Alt A, Medzihradsky F, Woods JH, Traynor JR. Activation of G protein by opioid receptors: role of receptor number and G-protein concentration. European Journal of Pharmacology. 396: 67-75. PMID 10822058 DOI: 10.1016/S0014-2999(00)00212-0  1
2000 Houshyar H, Mc Fadyen IJ, Woods JH, Traynor JR. Antinociceptive and other behavioral effects of the steroid SC17599 are mediated by the mu-opioid receptor. European Journal of Pharmacology. 395: 121-8. PMID 10794817 DOI: 10.1016/S0014-2999(00)00176-X  1
2000 McFadyen IJ, Ho JC, Mosberg HI, Traynor JR. Modifications of the cyclic mu receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et): effects on opioid receptor binding and activation. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 255-61. PMID 10727108 DOI: 10.1034/j.1399-3011.2000.00177.x  1
2000 Derrick I, Husbands SM, Broadbear J, Traynor JR, Woods JH, Lewis JW. Cinnamoyl derivatives of 7a-amino- and 7a-(aminomethyl)- N-(cyclopropylmethyl)-6,14-endo-ethanotetrahydronororipavines are high-potency opioid antagonists Helvetica Chimica Acta. 83: 3122-3130. DOI: 10.1002/1522-2675(20001220)83:12<3122::AID-HLCA3122>3.0.CO;2-2  1
2000 Coop A, Berzetei-Gurske I, Burnside J, Toll L, Traynor JR, Husbands SM, Lewis JW. Structural determinants of opioid activity in the orvinols and related structures. Ethers of 7,8-cyclopenta-fused analogs of buprenorphine Helvetica Chimica Acta. 83: 687-693. DOI: 10.1002/(SICI)1522-2675(20000412)83:4<687::AID-HLCA687>3.0.CO;2-W  1
2000 May EL, Aceto MD, Bowman ER, Traynor JR, Woods JH, Jacobson AE, Harris LS. Enantiomeric (-)-(1R,5R,9R) and (+)-(1S,5S,9S) heterocyclic N-substituted-normetazocines: Synthesis of potent and selective antinociceptives and opioid antagonists through N-substituent modification Medicinal Chemistry Research. 10: 178-185.  1
1999 Márki A, Monory K, Otvös F, Tóth G, Krassnig R, Schmidhammer H, Traynor JR, Roques BP, Maldonado R, Borsodi A. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. European Journal of Pharmacology. 383: 209-14. PMID 10585536 DOI: 10.1016/S0014-2999(99)00610-X  1
1999 Traynor JR, Guo L, Coop A, Lewis JW, Woods JH. Ring-constrained orvinols as analogs of buprenorphine: differences in opioid activity related to configuration of C(20) hydroxyl group. The Journal of Pharmacology and Experimental Therapeutics. 291: 1093-9. PMID 10565829  1
1999 Neilan CL, Akil H, Woods JH, Traynor JR. Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. British Journal of Pharmacology. 128: 556-62. PMID 10516632 DOI: 10.1038/sj.bjp.0702816  1
1999 Lee KO, Akil H, Woods JH, Traynor JR. Differential binding properties of oripavines at cloned mu- and delta-opioid receptors. European Journal of Pharmacology. 378: 323-30. PMID 10493109 DOI: 10.1016/S0014-2999(99)00460-4  1
1999 Johnson MD, Ko M, Choo KS, Traynor JR, Mosberg HI, Naughton NN, Woods JH. The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats. Brain Research. 839: 194-8. PMID 10482814 DOI: 10.1016/S0006-8993(99)01708-4  1
1999 Vivian JA, DeYoung MB, Sumpter TL, Traynor JR, Lewis JW, Woods JH. kappa-Opioid receptor effects of butorphanol in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 290: 259-65. PMID 10381785  1
1998 Barrallo A, Malvar FG, Gonzalez R, Rodriguez RE, Traynor JR. Cloning and characterization of a delta opioid receptor from zebrafish. Biochemical Society Transactions. 26: S360. PMID 10047874  1
1998 Wang C, McFadyen IJ, Traynor JR, Mosberg HI. Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models. Bioorganic & Medicinal Chemistry Letters. 8: 2685-8. PMID 9873603 DOI: 10.1016/S0960-894X(98)00472-7  1
1998 Traynor JR. Epibatidine and pain. British Journal of Anaesthesia. 81: 69-76. PMID 9771274  1
1998 Husbands SM, Sadd J, Broadbear JH, Woods JH, Martin J, Traynor JR, Aceto MD, Bowman ER, Harris LS, Lewis JW. 3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy. Journal of Medicinal Chemistry. 41: 3493-8. PMID 9719602 DOI: 10.1021/jm9810248  1
1998 Woods JH, Medzihradsky F, Smith CB, Winger G, Traynor JR. Evaluation of new compounds for opioid activity (1997). Nida Research Monograph. 178: 408-28. PMID 9686405  1
1998 Bell KM, Traynor JR. Dynorphin A(1-8): stability and implications for in vitro opioid activity. Canadian Journal of Physiology and Pharmacology. 76: 325-33. PMID 9673796 DOI: 10.1139/cjpp-76-3-325  1
1998 Alt A, Mansour A, Akil H, Medzihradsky F, Traynor JR, Woods JH. Stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding by endogenous opioids acting at a cloned mu receptor. The Journal of Pharmacology and Experimental Therapeutics. 286: 282-8. PMID 9655870  1
1998 Ko MC, Butelman ER, Traynor JR, Woods JH. Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 285: 518-26. PMID 9580592  1
1998 May EL, Jacobson AE, Mattson MV, Coop A, Aceto MD, Bowman ER, Traynor JR, Woods JH, Harris LS. Synthesis, in vitro, and in vivo activity of N-p-substituted-benzyl- (- )- and (+)-N-normetazocines, (-)- and (+)-N-normorphinans, N- norketobemidones, and (-)-N-nor-4,5-epoxymorphinans Medicinal Chemistry Research. 8: 311-321.  1
1998 Schmidhammer H, Krassnig R, Greiner E, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans. 16.1 14-0-alkyl derivatives of the μ opioid receptor antagonist cyprodime Heterocycles. 49: 489-497.  1
1997 Szekeres PG, Traynor JR. Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects. The Journal of Pharmacology and Experimental Therapeutics. 283: 1276-84. PMID 9400003  1
1997 Elliott J, Guo L, Traynor JR. Tolerance to mu-opioid agonists in human neuroblastoma SH-SY5Y cells as determined by changes in guanosine-5'-O-(3-[35S]-thio)triphosphate binding. British Journal of Pharmacology. 121: 1422-8. PMID 9257923 DOI: 10.1038/sj.bjp.0701253  1
1997 Schmidhammer H, Daurer D, Wieser M, Monory K, Borsodi A, Elliott J, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans. XIV. 14-Ethoxy-5-methyl substituted indolomorphinans with δ opioid receptor selectivity Bioorganic and Medicinal Chemistry Letters. 7: 151-156. DOI: 10.1016/S0960-894X(96)00599-9  1
1996 Traynor JR. The μ-opioid receptor Pain Reviews. 3: 221-248.  1
1995 Elliott J, Traynor JR. Evidence for lack of modulation of mu-opioid agonist action by delta-opioid agonists in the mouse vas deferens and guinea-pig ileum. British Journal of Pharmacology. 114: 1064-8. PMID 7780641  1
1995 Traynor JR, Nahorski SR. Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Molecular Pharmacology. 47: 848-54. PMID 7723747  1
1995 Schmidhammer H, Jennewein HK, Krassnig R, Traynor JR, Patel D, Bell K, Froschauer G, Mattersberger K, Jachs-Ewinger C, Jura P. Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. Journal of Medicinal Chemistry. 38: 3071-7. PMID 7636870  1
1995 Schmidhammer H, Stangl A, Fürst Z, Szabó E, Borsodi A, Patel D, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans.12.1 A phenethyl analogue of the μ-selective opioid receptor antagonist cyprodime Bioorganic and Medicinal Chemistry Letters. 5: 1923-1926. DOI: 10.1016/0960-894X(95)00325-N  1
1994 Wilcox RA, Challiss RA, Traynor JR, Fauq AH, Ognayanov VI, Kozikowski AP, Nahorski SR. Molecular recognition at the myo-inositol 1,4,5-trisphosphate receptor. 3-position substituted myo-inositol 1,4,5-trisphosphate analogues reveal the binding and Ca2+ release requirements for high affinity interaction with the myo-inositol 1,4,5-trisphosphate receptor. The Journal of Biological Chemistry. 269: 26815-21. PMID 7929418  1
1994 Rupniak NM, Patel S, Marwood R, Webb J, Traynor JR, Elliott J, Freedman SB, Fletcher SR, Hill RG. Antinociceptive and toxic effects of (+)-epibatidine oxalate attributable to nicotinic agonist activity. British Journal of Pharmacology. 113: 1487-93. PMID 7889306  1
1994 Elliott J, Smart D, Lambert DG, Traynor JR. Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine. European Journal of Pharmacology. 268: 447-50. PMID 7805771 DOI: 10.1016/0922-4106(94)90072-8  1
1994 Traynor JR. Opioid receptors and their subtypes: focus on peripheral isolated tissue preparations. Neurochemistry International. 24: 427-32. PMID 7647697 DOI: 10.1016/0197-0186(94)90090-6  1
1994 Bell K, Patel D, Traynor JR. Conformational studies and stabilities of small dynorphin peptides Regulatory Peptides. 53: S133-S134. DOI: 10.1016/0167-0115(94)90277-1  1
1994 Elliott J, Traynor JR. Lack of modulation of μ-opioid agonists by δ-opioid agonists in isolated tissue bioassay preparations Regulatory Peptides. 53: S41-S42. DOI: 10.1016/0167-0115(94)90231-3  1
1994 Schmidhammer H, Jennewein HK, Bell K, Patel D, Traynor JR. 3-Hydroxy analogues of the μ-selective opioid antagonist cyprodime Regulatory Peptides. 53: S37-S38. DOI: 10.1016/0167-0115(94)90229-1  1
1994 Schmidhammer H, Nussbaumer C, Patel D, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans. Part 10. 14-O-methyl derivatives of 5-methylnaltrexone and 5-methylnaloxone Helvetica Chimica Acta. 77: 1585-1589.  1
1993 Traynor JR, Elliott J. delta-Opioid receptor subtypes and cross-talk with mu-receptors. Trends in Pharmacological Sciences. 14: 84-6. PMID 8387705 DOI: 10.1016/0165-6147(93)90068-U  1
1993 Elliott J, Smart D, Traynor JR, Lambert DG. Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine. Biochemical Society Transactions. 21: 469S. PMID 8132037  1
1993 Dixon DM, Traynor JR. Conversion of dynorphin A(1-8) to [Leu5]-enkephalin in rat central nervous tissue during development. Neuropeptides. 25: 121-5. PMID 8105413 DOI: 10.1016/0143-4179(93)90091-N  1
1993 Schmidhammer H, Schratz A, Schmidt C, Patel D, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans. Part 9. 14-O-ethyl-5-methylnaltrexone, an opioid antagonist with unusual selectivity Helvetica Chimica Acta. 76: 476-480. DOI: 10.1002/hlca.19930760131  1
1992 Rodriguez FD, Bardaji E, Traynor JR. Differential effects of Mg2+ and other divalent cations on the binding of tritiated opioid ligands. Journal of Neurochemistry. 59: 467-72. PMID 1321228  1
1992 Franklin TG, Traynor JR. Alkylation of the μ-opioid receptor by N-ethylmaleimide and phenoxybenzamine: Differentiation of μ-opioid ligands by protection experiments Molecular Neuropharmacology. 1: 187-193.  1
1991 Franklin TG, Traynor JR. Alkylation with beta-funaltrexamine suggests differences between mu-opioid receptor systems in guinea-pig brain and myenteric-plexus. British Journal of Pharmacology. 102: 718-22. PMID 1364844  1
1990 Traynor JR, Hunter JC, Rodriguez RE, Hill RG, Hughes J. Delta-opioid receptor binding sites in rodent spinal cord. British Journal of Pharmacology. 100: 319-23. PMID 2165837  1
1990 Dixon DM, Traynor JR. Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin. British Journal of Pharmacology. 101: 674-8. PMID 1981690  1
1990 Rogers H, Hayes AG, Birch PJ, Traynor JR, Lawrence AJ. The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors. The Journal of Pharmacy and Pharmacology. 42: 358-9. PMID 1976787  1
1990 Dixon DM, Traynor JR. Formation of [Leu5]enkephalin from dynorphin A(1-8) by rat central nervous tissue in vitro. Journal of Neurochemistry. 54: 1379-85. PMID 1968961  1
1990 Lawrence AJ, Traynor JR. Characterisation of opioid binding sites using selective antagonists. Progress in Clinical and Biological Research. 328: 121-4. PMID 1968257  1
1989 Gill JC, Khan SE, Lockey PM, Marples BA, Traynor JR. Estrogen receptor binding and alkylating properties of A-ring aromatic 17,20- and 20,21-epoxy-norpregnanediols: potential target selective antitumour agents. Journal of Chemotherapy (Florence, Italy). 1: 1123-4. PMID 16312801  1
1989 Wood MS, Rodriguez FD, Traynor JR. Characterisation of kappa-opioid binding sites in rat and guinea-pig spinal cord. Neuropharmacology. 28: 1041-6. PMID 2572992 DOI: 10.1016/0028-3908(89)90115-9  1
1989 Wood MS, Traynor JR. [3H]diprenorphine binding to kappa-sites in guinea-pig and rat brain: evidence for apparent heterogeneity. Journal of Neurochemistry. 53: 173-8. PMID 2542456 DOI: 10.1111/j.1471-4159.1989.tb07310.x  1
1989 Gill JC, Marples BA, Traynor JR. Improved Preparation of 3,17 S-Dihydroxyoestra-1,3,5(10), 6-TETRAENE Synthetic Communications. 19: 155-158. DOI: 10.1080/00397918908050964  1
1989 Chagonda L, Lockey PM, Marples BA, Salt WG, Traynor JR. Cytotoxic action of alpha-methylene lactones towards HeLa cells in culture Phytotherapy Research. 3: 196-200.  1
1987 Traynor JR, Corbett AD, Kosterlitz HW. Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum. European Journal of Pharmacology. 137: 85-9. PMID 3038579 DOI: 10.1016/0014-2999(87)90185-3  1
1987 Kosterlitz HW, Paterson SJ, Robson LE, Traynor JR. Effects of cations on binding, in membrane suspensions, of various opioids at mu-sites of rabbit cerebellum and kappa-sites of guinea-pig cerebellum. British Journal of Pharmacology. 91: 431-7. PMID 3038237  1
1987 Traynor JR, Wood MS. Distribution of opioid binding sites in spinal cord. Neuropeptides. 10: 313-20. PMID 2829051 DOI: 10.1016/S0143-4179(87)90065-5  1
1987 Gill JC, Marples BA, Traynor JR. Regioselective 2-hydroxylation of 3-methoxyoestra-1,3,5(10)-trienes via chromium carbonyl complexes Tetrahedron Letters. 28: 2643-2644. DOI: 10.1016/S0040-4039(00)96170-7  1
1987 Traynor JR. Prodynorphin as a source of [Leu] enkephalin Trends in Pharmacological Sciences. 8: 47-48. DOI: 10.1016/0165-6147(87)90004-6  1
1986 Gill JC, Lockey PM, Marples BA, Traynor JR. 3,17 beta-Dihydroxy-20,21-epoxy-19-norpregna-1,3,5(10)-trienes: synthesis, rearrangement, cytotoxicity, and estrogen-receptor binding. Journal of Medicinal Chemistry. 29: 1537-40. PMID 3735321  1
1986 Stocker JF, Traynor JR. The action of various venoms on Escherichia coli. The Journal of Applied Bacteriology. 61: 383-8. PMID 3542922 DOI: 10.1111/j.1365-2672.1986.tb04300.x  1
1986 Appelmans N, Carroll JA, Rance MJ, Simon EJ, Traynor JR. Sodium ions increase the binding of the antagonist peptide ICI 174864 to the delta-opiate receptor. Neuropeptides. 7: 139-43. PMID 3010168 DOI: 10.1016/0143-4179(86)90089-2  1
1986 Traynor JR, Wood MS, Carroll JA, Rance MJ. Kappa opioid binding sites in rat spinal cord. Nida Research Monograph. 75: 73-6. PMID 2829011  1
1986 Marples BA, Saint CG, Traynor JR. Regiochemistry of nucleophilic opening of β-substituted styrene oxides with thiolate anions: Model experiments in the synthesis of leukotriene analogues Journal of the Chemical Society, Perkin Transactions 1. 567-574.  1
1985 Miller L, Rance MJ, Shaw JS, Traynor JR. Conversion of dynorphin-(1-9) to [Leu5]enkephalin by the mouse vas deferens in vitro. European Journal of Pharmacology. 116: 159-63. PMID 2865158 DOI: 10.1016/0014-2999(85)90197-9  1
1984 Chagonda LS, Lockey PM, Marples BA, Traynor JR. Synthesis and cytotoxic activity of estrogen alpha-methylene-delta-lactones. Steroids. 43: 283-92. PMID 6523545 DOI: 10.1016/0039-128X(84)90046-1  1
1984 Traynor JR, Rance MJ. Opiate binding in the rat spinal cord: evidence for mu and delta sites. Neuropeptides. 5: 81-4. PMID 6099519 DOI: 10.1016/0143-4179(84)90032-5  1
1984 Traynor JR. Opioid binding sites in the spinal cord Trends in Pharmacological Sciences. 5: 495-496. DOI: 10.1016/0165-6147(84)90523-6  1
1982 Authi KS, Solanky A, Traynor JR. Inhibition of an inflammatory exudate phospholipase A2 by an endogenous inhibitor of polymorphonuclear leucocytes. Pharmacological Research Communications. 14: 401-7. PMID 7111357 DOI: 10.1016/S0031-6989(82)80068-4  1
1982 Authi KS, Traynor JR. Stimulation of polymorphonuclear leucocyte phospholipase A2 activity by chloroquine and mepacrine. The Journal of Pharmacy and Pharmacology. 34: 736-8. PMID 6129307  1
1982 Traynor JR, Kelly PD, Rance MJ. Multiple opiate binding sites in rat spinal cord. Life Sciences. 31: 1377-80. PMID 6128660 DOI: 10.1016/0024-3205(82)90385-X  1
1982 Traynor JR, Kelly PD. Effects of narcotic analgesics on lipase activity in vitro. Pharmacological Research Communications. 14: 327-39. PMID 6124979 DOI: 10.1016/S0031-6989(82)80102-1  1
1982 Kelly PD, Rance MJ, Traynor JR. Properties of opiate binding in the rat spinal cord Neuropeptides. 2: 319-324. DOI: 10.1016/0143-4179(82)90069-5  1
1981 Traynor JR, Authi KS. Phospholipase A2 activity of lysosomal origin secreted by polymorphonuclear leucocytes during phagocytosis or on treatment with calcium. Biochimica Et Biophysica Acta. 665: 571-7. PMID 7295751 DOI: 10.1016/0005-2760(81)90272-1  1
1980 Dehal SS, Marples BA, Stretton RJ, Traynor JR. Steroidal alpha-methylene delta-lactones as potential antitumor agents. Journal of Medicinal Chemistry. 23: 90-2. PMID 7359520  1
1980 Authi KS, Traynor JR. Release of lysosomal phospholipase A from rabbit neutrophil leucocytes [proceedings]. British Journal of Pharmacology. 68: 125P. PMID 7357143  1
1980 Horne JA, Percival JE, Traynor JR. Aspirin and human sleep. Electroencephalography and Clinical Neurophysiology. 49: 409-13. PMID 6158420  1
1980 Kelly PD, Lane AC, Rance MJ, Traynor JR. Opiate receptors in rat spinal cord British Journal of Pharmacology. 70: 153p-154p.  1
1979 Salt WG, Traynor JR. Interactions between amethocaine (tetracaine) and non-growing cultures of Escherichia coli. The Journal of Pharmacy and Pharmacology. 31: 41-2. PMID 32365  1
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