Roberta Diaz Brinton - Publications

Affiliations: 
University of Southern California, Los Angeles, CA, United States 

153 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hay M, Barnes C, Huentelman M, Brinton R, Ryan L. Hypertension and Age-Related Cognitive Impairment: Common Risk Factors and a Role for Precision Aging. Current Hypertension Reports. 22: 80. PMID 32880739 DOI: 10.1007/S11906-020-01090-W  0.318
2020 Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, Brinton RD, Carrero JJ, DeMeo DL, De Vries GJ, Epperson CN, Govindan R, Klein SL, Lonardo A, Maki PM, McCullough LD, Regitz-Zagrosek V, Regensteiner JG, et al. Sex and gender: modifiers of health, disease, and medicine. Lancet (London, England). 396: 565-582. PMID 32828189 DOI: 10.1016/S0140-6736(20)31561-0  0.31
2020 Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, Beal MF, Bergersen LH, Brinton RD, de la Monte S, Eckert A, Harvey J, Jeggo R, Jhamandas JH, Kann O, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nature Reviews. Drug Discovery. PMID 32709961 DOI: 10.1038/S41573-020-0072-X  0.371
2020 Chen S, Wang T, Yao J, Brinton RD. Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer's Disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 32632771 DOI: 10.1007/S13311-020-00874-X  0.535
2020 Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Annals of the New York Academy of Sciences. PMID 32472577 DOI: 10.1111/Nyas.14371  0.377
2020 Wang Y, Shang Y, Mishra A, Bacon E, Yin F, Brinton R. Midlife Chronological and Endocrinological Transitions in Brain Metabolism: System Biology Basis for Increased Alzheimer's Risk in Female Brain. Scientific Reports. 10: 8528. PMID 32444841 DOI: 10.1038/S41598-020-65402-5  0.408
2020 Mi Y, Qi G, Brinton RD, Yin F. Mitochondria Targeted Therapeutics for Alzheimer's Disease: The Good. The Bad. The Potential. Antioxidants & Redox Signaling. PMID 32143551 DOI: 10.1089/Ars.2020.8070  0.315
2020 Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, et al. Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome. Nature Communications. 11: 1148. PMID 32123170 DOI: 10.1038/S41467-020-14959-W  0.395
2020 Wang Y, Mishra A, Brinton RD. Transitions in metabolic and immune systems from pre-menopause to post-menopause: implications for age-associated neurodegenerative diseases. F1000research. 9. PMID 32047612 DOI: 10.12688/f1000research.21599.1  0.388
2020 Shang Y, Mishra A, Wang T, Wang Y, Desai M, Chen S, Mao Z, Do L, Bernstein AS, Trouard TP, Brinton RD. Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice. Plos One. 15: e0225392. PMID 31917799 DOI: 10.1371/Journal.Pone.0225392  0.367
2020 Galea LA, Brinton RD, Cameron HA, Conrad CD, Lupien SJ, Shansky RM, Woolley CS, Gould E. A Tribute to Bruce S. McEwen Trends in Neurosciences. 43: 127-130. DOI: 10.1016/J.Tins.2020.01.006  0.76
2019 Rahman A, Jackson H, Hristov H, Isaacson RS, Saif N, Shetty T, Etingin O, Henchcliffe C, Brinton RD, Mosconi L. Sex and Gender Driven Modifiers of Alzheimer's: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risks. Frontiers in Aging Neuroscience. 11: 315. PMID 31803046 DOI: 10.3389/fnagi.2019.00315  0.395
2019 Wang T, Yao J, Chen S, Mao Z, Brinton RD. Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31664643 DOI: 10.1007/S13311-019-00793-6  0.592
2019 Wang Y, Hernandez G, Mack WJ, Schneider LS, Yin F, Brinton RD. Retrospective analysis of phytoSERM for management of menopause-associated vasomotor symptoms and cognitive decline: a pilot study on pharmacogenomic effects of mitochondrial haplogroup and APOE genotype on therapeutic efficacy. Menopause (New York, N.Y.). PMID 31567873 DOI: 10.1097/Gme.0000000000001418  0.34
2019 Sriprasert I, Mack WJ, Hodis HN, Allayee H, Brinton RD, Karim R. Effect of ApoE4 Genotype on the Association Between Metabolic Phenotype and Subclinical Atherosclerosis in Postmenopausal Women. The American Journal of Cardiology. PMID 31362877 DOI: 10.1016/J.Amjcard.2019.06.022  0.321
2019 Schneider LS, Hernandez G, Zhao L, Franke AA, Chen YL, Pawluczyk S, Mack WJ, Brinton RD. Safety and feasibility of estrogen receptor-β targeted phytoSERM formulation for menopausal symptoms: phase 1b/2a randomized clinical trial. Menopause (New York, N.Y.). PMID 30889096 DOI: 10.1097/Gme.0000000000001325  0.313
2019 Mao Z, Shang Y, Berghout J, Lussier Y, Yin F, Brinton RD. P1-202: EMERGENCE OF AN ALZHEIMER'S DISEASE BIOENERGETIC ENDOPHENOTYPE IN MID-LIFE: PRECLINICAL MODEL Alzheimer's & Dementia. 15: P314-P314. DOI: 10.1016/J.Jalz.2019.06.757  0.367
2019 Yin F, Shang Y, Wang Y, Mishra A, Desai MK, Mao Z, Brinton RD. P1-194: IMPACT OF APOE GENOTYPE ON THE SEX DIFFERENCES IN BIOENERGETICS AND ALZHEIMER'S RISKS IN THE AGING MOUSE BRAIN Alzheimer's & Dementia. 15: P311-P311. DOI: 10.1016/J.Jalz.2019.06.749  0.398
2019 Chen S, Yao J, Wang T, Brinton RD. P3-060: ALLOPREGNANOLONE REVERSED OVARIECTOMY-INDUCED BIOENERGETIC DEFICITS IN FEMALE TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P948-P949. DOI: 10.1016/J.Jalz.2019.06.3087  0.549
2019 Shang Y, Hernandez GD, Lopez C, Yin F, Schneider LS, Brinton RD. P3-015: ALLOPREGNANOLONE SHOWS SIGNIFICANT EFFECT ON THE LIPID PATHWAYS FROM PLASMA METABOLOMIC ANALYSIS OF ALZHEIMER'S CLINICAL TRIAL Alzheimer's & Dementia. 15: P930-P930. DOI: 10.1016/J.Jalz.2019.06.3041  0.32
2018 Mosconi L, Rahman A, Diaz I, Wu X, Scheyer O, Hristov HW, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD. Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study. Plos One. 13: e0207885. PMID 30540774 DOI: 10.1371/journal.pone.0207885  0.422
2018 Karim R, Koc M, Rettberg JR, Hodis HN, Henderson VW, St John JA, Allayee H, Brinton RD, Mack WJ. Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease. Menopause (New York, N.Y.). PMID 29975287 DOI: 10.1097/Gme.0000000000001160  0.795
2018 Chen S, Kumar N, Mao Z, Sitruk-Ware R, Brinton RD. Therapeutic progestin segesterone acetate promotes neurogenesis: implications for sustaining regeneration in female brain. Menopause (New York, N.Y.). PMID 29846284 DOI: 10.1097/GME.0000000000001135  0.367
2017 Mosconi L, Berti V, Guyara-Quinn C, McHugh P, Petrongolo G, Osorio RS, Connaughty C, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Swerdlow RH, Brinton RD. Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. Plos One. 12: e0185926. PMID 29016679 DOI: 10.1371/Journal.Pone.0185926  0.428
2017 Hernandez G, Zhao L, Franke AA, Chen YL, Mack WJ, Brinton RD, Schneider LS. Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor β-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause (New York, N.Y.). PMID 28926513 DOI: 10.1097/Gme.0000000000000984  0.302
2017 Mosconi L, Berti V, Quinn C, McHugh P, Petrongolo G, Varsavsky I, Osorio RS, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD. Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging. Neurology. PMID 28855400 DOI: 10.1212/WNL.0000000000004425  0.389
2017 Wang JY, Trivedi AM, Carrillo NR, Yang J, Schneider A, Giulivi C, Adams P, Tassone F, Kim K, Rivera SM, Lubarr N, Wu CY, Irwin RW, Brinton RD, Olichney JM, et al. Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28707277 DOI: 10.1007/S13311-017-0555-6  0.616
2017 Yin F, Yao J, Brinton RD, Cadenas E. Editorial: The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration. Frontiers in Aging Neuroscience. 9: 209. PMID 28701949 DOI: 10.3389/Fnagi.2017.00209  0.495
2016 Wang Y, Brinton RD. Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex. Frontiers in Aging Neuroscience. 8: 232. PMID 27757081 DOI: 10.3389/fnagi.2016.00232  0.402
2016 Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC. Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27692800 DOI: 10.1016/J.Jalz.2016.08.004  0.378
2016 Zhao L, Mao Z, Woody SK, Brinton RD. Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease. Neurobiology of Aging. 42: 69-79. PMID 27143423 DOI: 10.1016/j.neurobiolaging.2016.02.011  0.396
2016 Rettberg JR, Dang H, Hodis HN, Henderson VW, St John JA, Mack WJ, Brinton RD. Identifying postmenopausal women at risk for cognitive decline within a healthy cohort using a panel of clinical metabolic indicators: potential for detecting an at-Alzheimer's risk metabolic phenotype. Neurobiology of Aging. 40: 155-63. PMID 26973115 DOI: 10.1016/J.Neurobiolaging.2016.01.011  0.798
2016 Riedel BC, Thompson PM, Brinton RD. Age, APOE and Sex: Triad of Risk of Alzheimer's Disease. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26969397 DOI: 10.1016/J.Jsbmb.2016.03.012  0.79
2016 Irwin RW, Solinsky CM, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. P1-072: Comparative Pharmacokinetic Assessment of Allopregnanolone to Develop a Regenerative Therapeutic for Mild Cognitive Impairment and Early Alzheimer’s Disease Alzheimer's & Dementia. 12: P430-P430. DOI: 10.1016/J.Jalz.2016.06.820  0.639
2016 Brinton RD, Swanson HM, Irwin RW. P4-026: Allopregnanolone Promotes Cholesterol and Amyloid-Beta Clearance Mechanisms: Assessment of a Regenerative Therapeutic for Alzheimer’s Disease Alzheimer's & Dementia. 12: P1024-P1025. DOI: 10.1016/J.Jalz.2016.06.2115  0.629
2016 Klosinski L, Yao J, Fonteh A, Harrington M, Christensen T, Trushina E, Brinton RD. P2-117: Perimenopause in APOE4 Brain: Accelerated Myelin Catabolism for Fuel Alzheimer's & Dementia. 12: P656-P657. DOI: 10.1016/J.Jalz.2016.06.1487  0.478
2015 Klosinski LP, Yao J, Yin F, Fonteh AN, Harrington MG, Christensen TA, Trushina E, Brinton RD. White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease. Ebiomedicine. 2: 1888-904. PMID 26844268 DOI: 10.1016/J.Ebiom.2015.11.002  0.577
2015 Irwin RW, Solinsky CM, Loya CM, Salituro FG, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease. Plos One. 10: e0128313. PMID 26039057 DOI: 10.1371/Journal.Pone.0128313  0.651
2015 Brinton RD, Yao J, Yin F, Mack WJ, Cadenas E. Perimenopause as a neurological transition state. Nature Reviews. Endocrinology. 11: 393-405. PMID 26007613 DOI: 10.1038/Nrendo.2015.82  0.521
2015 Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiology of Aging. 36: 2282-95. PMID 25921624 DOI: 10.1016/J.Neurobiolaging.2015.03.013  0.544
2015 Caldwell CC, Yao J, Brinton RD. Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 66-80. PMID 25534394 DOI: 10.1007/S13311-014-0324-8  0.546
2015 Karim R, Stanczyk FZ, Brinton RD, Rettberg J, Hodis HN, Mack WJ. Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women. The Journal of Clinical Endocrinology and Metabolism. 100: 508-15. PMID 25405497 DOI: 10.1210/Jc.2014-1839  0.774
2015 Irwin RW, Kim K, Green CE, Solinsky CM, Bauer G, Rogawski MA, Rodgers KE, Brinton RD. P1-303: Allopregnanolone chronic exposure using regenerative treatment regimen: Preclinical ind enabling toxicology indicating safety Alzheimer's & Dementia. 11: P472-P473. DOI: 10.1016/J.Jalz.2015.06.518  0.592
2015 Klosinski LP, Yao J, Yin F, Fonteh AN, Harrington MG, Christensen TA, Trushina E, Brinton RD. White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease Ebiomedicine. DOI: 10.1016/j.ebiom.2015.11.002  0.472
2014 Irwin RW, Solinsky CM, Brinton RD. Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders. Frontiers in Cellular Neuroscience. 8: 203. PMID 25126056 DOI: 10.3389/Fncel.2014.00203  0.685
2014 Irwin RW, Brinton RD. Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise. Progress in Neurobiology. 113: 40-55. PMID 24044981 DOI: 10.1016/J.Pneurobio.2013.08.004  0.681
2014 Rettberg JR, Yao J, Brinton RD. Estrogen: a master regulator of bioenergetic systems in the brain and body. Frontiers in Neuroendocrinology. 35: 8-30. PMID 23994581 DOI: 10.1016/J.Yfrne.2013.08.001  0.809
2014 Brinton RD, Zhao L, Yin F, Yao J, Cadenas E. P1-101: SEX DIFFERENCES IN BIOENERGETIC AGING OF THE BRAIN AND RISK OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P339-P339. DOI: 10.1016/J.Jalz.2014.05.338  0.561
2013 Ding F, Yao J, Rettberg JR, Chen S, Brinton RD. Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention. Plos One. 8: e79977. PMID 24244584 DOI: 10.1371/Journal.Pone.0079977  0.797
2013 Fuente-Martin E, Garcia-Caceres C, Morselli E, Clegg DJ, Chowen JA, Finan B, Brinton RD, Tschöp MH. Estrogen, astrocytes and the neuroendocrine control of metabolism. Reviews in Endocrine & Metabolic Disorders. 14: 331-8. PMID 24009071 DOI: 10.1007/S11154-013-9263-7  0.346
2013 Zhao L, Mao Z, Chen S, Schneider LS, Brinton RD. Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 37: 403-19. PMID 23948892 DOI: 10.3233/Jad-122341  0.415
2013 Sancheti H, Akopian G, Yin F, Brinton RD, Walsh JP, Cadenas E. Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. Plos One. 8: e69830. PMID 23875003 DOI: 10.1371/Journal.Pone.0069830  0.36
2013 Jiang T, Yin F, Yao J, Brinton RD, Cadenas E. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway. Aging Cell. 12: 1021-31. PMID 23815272 DOI: 10.1111/Acel.12127  0.52
2013 Singh M, Simpkins JW, Simpkins JW, Bimonte-Nelson HA, Bimonte-Nelson HA, Brinton RD, Brinton RD. Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease. Brain Research. 1514: 1-2. PMID 23726132 DOI: 10.1016/J.Brainres.2013.04.044  0.399
2013 Ding F, Yao J, Zhao L, Mao Z, Chen S, Brinton RD. Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's. Plos One. 8: e59825. PMID 23555795 DOI: 10.1371/Journal.Pone.0059825  0.662
2013 Yao J, Zhao L, Mao Z, Chen S, Wong KC, To J, Brinton RD. Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments. Brain Research. 1514: 128-41. PMID 23428542 DOI: 10.1016/J.Brainres.2013.02.021  0.572
2013 Zhao L, Yao J, Ding F, Chen S, Klosinski L, Rettberg J, Brinton R. P2-011: A bioenergetic trajectory of female brain aging and Alzheimer's disease 1: Implications for risk prevention and treatment Alzheimer's & Dementia. 9: P349-P349. DOI: 10.1016/J.Jalz.2013.05.653  0.791
2013 Rettberg J, Mack W, Hodis H, Dang H, Zhao L, Schneider L, Stanczyk F, Brinton R. P2-010: A bioenergetic trajectory of female brain aging and Alzheimer's disease 3: Development of metabolic and physiological biomarker profiles for early detection of women at risk for Alzheimer's disease Alzheimer's & Dementia. 9: P348-P349. DOI: 10.1016/J.Jalz.2013.05.652  0.82
2013 Klosinski L, Yao J, Chen S, Mao Z, Zhao L, Brinton R. P2-008: A bioenergetic trajectory of female brain aging and Alzheimer's disease 2: Mechanistic link between mitochondrial dysfunction and white matter degeneration in the normal mammalian aging female brain Alzheimer's & Dementia. 9: P348-P348. DOI: 10.1016/J.Jalz.2013.05.650  0.563
2013 Irwin R, Chen S, To J, Zhu M, Yao J, Rodgers K, Bolger M, Brinton R. P4-016: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 2: Bridging subcutaneous to intravenous formulations for clinical trials Alzheimer's & Dementia. 9: P710-P711. DOI: 10.1016/J.Jalz.2013.05.1404  0.702
2013 Chen S, Yao J, Wong K, Brinton R. P4-014: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 4: Impact on neuronal versus gliosis phenotypic differentiation Alzheimer's & Dementia. 9: P710-P710. DOI: 10.1016/J.Jalz.2013.05.1402  0.545
2013 Yao J, Chen S, Wong K, Irwin R, Brinton R. P4-013: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 3: Evidence for potentiation of brain mitochondrial function Alzheimer's & Dementia. 9: P709-P710. DOI: 10.1016/J.Jalz.2013.05.1401  0.743
2013 Brinton R, Irwin R, Mack W, Rodgers K, Bauer G, Rogawski M, Schneider L. P4-012: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 1: From discovery to phase I multiple-ascending-dose clinical trial Alzheimer's & Dementia. 9: P709-P709. DOI: 10.1016/J.Jalz.2013.05.1400  0.639
2012 Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ. 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology. 153: 5467-79. PMID 22962256 DOI: 10.1210/En.2012-1464  0.398
2012 Yao J, Brinton RD. Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease. Advances in Pharmacology (San Diego, Calif.). 64: 327-71. PMID 22840752 DOI: 10.1016/B978-0-12-394816-8.00010-6  0.566
2012 Reiman EM, Brinton RD, Katz R, Petersen RC, Negash S, Mungas D, Aisen PS. Considerations in the design of clinical trials for cognitive aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 766-72. PMID 22573913 DOI: 10.1093/Gerona/Gls124  0.309
2012 Wang JM, Hou X, Adeosun S, Hill R, Henry S, Paul I, Irwin RW, Ou XM, Bigler S, Stockmeier C, Brinton RD, Gomez-Sanchez E. A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats. Plos One. 7: e33493. PMID 22428062 DOI: 10.1371/Journal.Pone.0033493  0.633
2012 Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. Plos One. 7: e31267. PMID 22393359 DOI: 10.1371/Journal.Pone.0031267  0.358
2012 Sun C, Ou X, Farley JM, Stockmeier C, Bigler S, Brinton RD, Wang JM. Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease. Current Alzheimer Research. 9: 473-80. PMID 22272610 DOI: 10.2174/156720512800492567  0.313
2012 Bali N, Arimoto JM, Iwata N, Lin SW, Zhao L, Brinton RD, Morgan TE, Finch CE. Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis. Endocrinology. 153: 759-69. PMID 22147012 DOI: 10.1210/En.2011-1699  0.328
2012 Irwin RW, Yao J, To J, Hamilton RT, Cadenas E, Brinton RD. Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function. Journal of Neuroendocrinology. 24: 236-48. PMID 22070562 DOI: 10.1111/J.1365-2826.2011.02251.X  0.716
2012 Singh C, Liu L, Wang JM, Irwin RW, Yao J, Chen S, Henry S, Thompson RF, Brinton RD. Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice. Neurobiology of Aging. 33: 1493-506. PMID 21803451 DOI: 10.1016/J.Neurobiolaging.2011.06.008  0.792
2012 Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, Brinton RD. Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid. Neurobiology of Aging. 33: 1507-21. PMID 21514693 DOI: 10.1016/J.Neurobiolaging.2011.03.001  0.734
2012 Mao Z, Zhao L, Yao J, Ding F, Cadenas E, Brinton R. P2-129: Effects of age and reproductive status on gene expression in the female hippocampus Alzheimer's & Dementia. 8: P305-P305. DOI: 10.1016/J.Jalz.2012.05.834  0.609
2012 Rettberg J, Mack W, Hodis H, Zhao L, Stanczyk F, Brinton R. P2-053: Biomarkers of metabolic function for early detection of women at risk for Alzheimer's disease Alzheimer's & Dementia. 8: P281-P282. DOI: 10.1016/J.Jalz.2012.05.757  0.802
2012 Ding F, Luo J, Yao J, Mao Z, Chen S, Chen K, Reiman E, Brinton R. P1-135: Ovarian hormone loss induced decline in glucose availability and shift to alternative substrates in brain Alzheimer's & Dementia. 8: P153-P153. DOI: 10.1016/J.Jalz.2012.05.412  0.639
2012 Yao J, Ding F, Chen S, Mao Z, Cadenas E, Brinton R. P4-226: Shift in brain mitochondrial bioenergetics in aging and Alzheimer's: Implications for disease prevention and treatment Alzheimer's & Dementia. 8: P714-P714. DOI: 10.1016/J.Jalz.2012.05.1931  0.687
2012 Adeosun S, Hou X, Zheng B, Paul I, Irwin R, Brinton R, Wang J. Motor deficits in mouse models of Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1813  0.633
2012 Irwin R, Chen S, Zhu M, Hernandez E, Rodgers K, Wang J, Bolger M, Brinton R. P2-393: Allopregnanolone as a regenerative therapeutic for Alzheimer's: Formulation development for clinical trials Alzheimer's & Dementia. 8: P400-P400. DOI: 10.1016/J.Jalz.2012.05.1103  0.639
2012 Zhu M, Irwin R, Chen S, Brinton R. P2-386: Allopregnanolone as a regenerative drug candidate in a female mouse model of Alzheimer's disease Alzheimer's & Dementia. 8: P398-P398. DOI: 10.1016/J.Jalz.2012.05.1096  0.651
2011 Irwin RW, Wang JM, Chen S, Brinton RD. Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. Frontiers in Endocrinology. 2: 117. PMID 22654847 DOI: 10.3389/Fendo.2011.00117  0.672
2011 Yao J, Rettberg JR, Klosinski LP, Cadenas E, Brinton RD. Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Molecular Aspects of Medicine. 32: 247-57. PMID 22024249 DOI: 10.1016/J.Mam.2011.10.005  0.813
2011 Chen S, Wang JM, Irwin RW, Yao J, Liu L, Brinton RD. Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. Plos One. 6: e24293. PMID 21918687 DOI: 10.1371/Journal.Pone.0024293  0.793
2011 Yao J, Brinton RD. Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment. Current Pharmaceutical Design. 17: 3474-9. PMID 21902662 DOI: 10.2174/138161211798072517  0.591
2011 Yao J, Chen S, Mao Z, Cadenas E, Brinton RD. 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. Plos One. 6: e21788. PMID 21747957 DOI: 10.1371/Journal.Pone.0021788  0.586
2011 Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Research. 1379: 11-22. PMID 21241683 DOI: 10.1016/J.Brainres.2011.01.029  0.795
2011 Wu TW, Chen S, Brinton RD. Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons. Brain Research. 1379: 34-43. PMID 21241678 DOI: 10.1016/J.Brainres.2011.01.034  0.495
2011 Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Research. 1379: 23-33. PMID 21238431 DOI: 10.1016/J.Brainres.2011.01.012  0.785
2011 Irwin RW, Yao J, Ahmed SS, Hamilton RT, Cadenas E, Brinton RD. Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology. 152: 556-67. PMID 21159850 DOI: 10.1210/En.2010-1061  0.724
2011 Yao J, Chen S, Cadenas E, Brinton RD. Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone. Brain Research. 1379: 2-10. PMID 21134358 DOI: 10.1016/J.Brainres.2010.11.090  0.532
2011 Zhao L, Yao J, Mao Z, Chen S, Wang Y, Brinton RD. 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiology of Aging. 32: 1949-63. PMID 20053478 DOI: 10.1016/J.Neurobiolaging.2009.12.010  0.562
2011 Yao J, Chen S, Irwin R, Mao Z, Cadenas E, Brinton R. P3-476: Preclinical efficacy of 2-Deoxyglucose to sustain mitochondrial metabolic function and delay progression of Alzheimer's pathology Alzheimer's & Dementia. 7: S667-S668. DOI: 10.1016/J.Jalz.2011.05.1921  0.729
2011 Wang J, Adeosun S, Jiao Y, Zheng B, Henry S, Hou X, Sun C, Pani A, Kyle P, Farley J, Paul I, Bigler S, Stockmeier C, Brinton R, Smeyne R. P3-473: The impact of a neurogenic agent, allopregnanolone, in rodent models of Alzheimer's and Parkinson's disease Alzheimer's & Dementia. 7: S667-S667. DOI: 10.1016/J.Jalz.2011.05.1918  0.365
2011 Liu L, Brinton RD. Gonadal Hormones, Neurosteroids, and Clinical Progestins as Neurogenic Regenerative Agents: Therapeutic Implications Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis. 281-303. DOI: 10.1002/9783527633968.ch17  0.582
2010 Liu L, Zhao L, She H, Chen S, Wang JM, Wong C, McClure K, Sitruk-Ware R, Brinton RD. Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo. Endocrinology. 151: 5782-94. PMID 20943809 DOI: 10.1210/En.2010-0005  0.665
2010 Henderson VW, Brinton RD. Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy. Progress in Brain Research. 182: 77-96. PMID 20541661 DOI: 10.1016/S0079-6123(10)82003-5  0.439
2010 Yao J, Hamilton RT, Cadenas E, Brinton RD. Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Biochimica Et Biophysica Acta. 1800: 1121-6. PMID 20538040 DOI: 10.1016/J.Bbagen.2010.06.002  0.574
2010 Wang JM, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 6498-503. PMID 20231471 DOI: 10.1073/Pnas.1001422107  0.781
2010 Wang M, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 14, (6498-6503) DOI: 10.1073/pnas. 1001422107) Proceedings of the National Academy of Sciences of the United States of America. 107: 11145. DOI: 10.1073/pnas.1006236107  0.673
2010 Irwin RW, Singh C, Liu L, Wang J, Yao J, Chen S, Henry S, Thompson RF, Brinton RD. P3-369: Allopregnanolone promotes neurogenesis, restores cognitive function and reduces Alzheimer's pathology in adult triple transgenic Alzheimer's mice: Preclinical development and formulation Alzheimer's & Dementia. 6: S560-S560. DOI: 10.1016/J.Jalz.2010.05.1911  0.794
2010 Yao J, Irwin R, Chen S, Brinton RD. P3-365: Deficits in mitochondrial bioenergetics and mitochondrial beta-amyloid deposition in brain are associated with reproductive senescence and loss of ovarian hormones: Prevention by estradiol Alzheimer's & Dementia. 6: S559-S559. DOI: 10.1016/J.Jalz.2010.05.1907  0.714
2010 Brinton RD, Gore AC, Schmidt PJ, Morrison JH. Reproductive aging of females: Neural systems Hormones, Brain and Behavior Online. 2199-2224. DOI: 10.1016/B978-008088783-8.00068-1  0.326
2009 Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 14670-5. PMID 19667196 DOI: 10.1073/Pnas.0903563106  0.79
2009 Liu L, Wang J, Zhao L, Nilsen J, McClure K, Wong K, Brinton RD. Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2. Endocrinology. 150: 3186-96. PMID 19359388 DOI: 10.1210/En.2008-1447  0.73
2009 Asthana S, Brinton RD, Henderson VW, McEwen BS, Morrison JH, Schmidt PJ. Frontiers proposal. National Institute on Aging "bench to bedside: estrogen as a case study". Age (Dordrecht, Netherlands). 31: 199-210. PMID 19277902 DOI: 10.1007/s11357-009-9087-2  0.5
2008 Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J. Progesterone receptors: form and function in brain. Frontiers in Neuroendocrinology. 29: 313-39. PMID 18374402 DOI: 10.1016/J.Yfrne.2008.02.001  0.63
2008 Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology. 149: 3167-75. PMID 18292191 DOI: 10.1210/En.2007-1227  0.789
2008 Wang JM, Liu L, Brinton RD. Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway. Endocrinology. 149: 208-18. PMID 17962344 DOI: 10.1210/En.2007-1155  0.649
2008 Wang JM, Liu L, Irwin RW, Chen S, Brinton RD. Regenerative potential of allopregnanolone. Brain Research Reviews. 57: 398-409. PMID 17931704 DOI: 10.1016/J.Brainresrev.2007.08.010  0.786
2007 Wang JM, Irwin RW, Liu L, Chen S, Brinton RD. Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent. Current Alzheimer Research. 4: 510-7. PMID 18220513 DOI: 10.2174/156720507783018262  0.787
2007 Nilsen J, Irwin RW, Gallaher TK, Brinton RD. Estradiol in vivo regulation of brain mitochondrial proteome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14069-77. PMID 18094246 DOI: 10.1523/Jneurosci.4391-07.2007  0.756
2007 Zhao L, Jin C, Mao Z, Gopinathan MB, Rehder K, Brinton RD. Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons. Journal of Medicinal Chemistry. 50: 4471-81. PMID 17696335 DOI: 10.1021/Jm070546X  0.35
2007 Wang JM, Liu L, Irwin RW, Chen S, Chung EJ, Seligman E, Brinton RD. P-076: Estrogen receptor-selective ligands regulate ApoE expression and neurogenesis in 3xTgAD mouse hippocampus Alzheimer's & Dementia. 3: S123-S123. DOI: 10.1016/J.Jalz.2007.04.329  0.744
2007 Nilsen J, Irwin RW, Yao J, Brinton RD. P-073: Prevention of Alzheimer's pathology: Estrogen targeting of mitochondrial function Alzheimer's & Dementia. 3: S122-S122. DOI: 10.1016/J.Jalz.2007.04.326  0.787
2007 Wang JM, Singh C, Irwin RW, Liu L, Chen S, Thompson RF, Brinton RD. O2-04-07: Allopregnanolone reverses the neurogenic and cognitive deficits of triple transgenic Alzheimer mice Alzheimer's & Dementia. 3: S194-S194. DOI: 10.1016/J.Jalz.2007.04.302  0.739
2006 Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. Bmc Neuroscience. 7: 74. PMID 17083736 DOI: 10.1186/1471-2202-7-74  0.742
2006 Wang JM, Irwin RW, Brinton RD. Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 16983-8. PMID 17077142 DOI: 10.1073/Pnas.0608128103  0.661
2006 Morrison JH, Brinton RD, Schmidt PJ, Gore AC. Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10332-48. PMID 17035515 DOI: 10.1523/Jneurosci.3369-06.2006  0.316
2006 Chen S, Nilsen J, Brinton RD. Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications. Endocrinology. 147: 5303-13. PMID 16916950 DOI: 10.1210/en.2006-0495  0.598
2006 Nilsen J, Morales A, Brinton RD. Medroxyprogesterone acetate exacerbates glutamate excitotoxicity. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology. 22: 355-61. PMID 16864144 DOI: 10.1080/09513590600863337  0.589
2006 Brinton RD, Wang JM. Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent. Current Alzheimer Research. 3: 185-90. PMID 16842093 DOI: 10.2174/156720506777632817  0.376
2006 Kim MT, Soussou W, Gholmieh G, Ahuja A, Tanguay A, Berger TW, Brinton RD. 17beta-Estradiol potentiates field excitatory postsynaptic potentials within each subfield of the hippocampus with greatest potentiation of the associational/commissural afferents of CA3. Neuroscience. 141: 391-406. PMID 16725270 DOI: 10.1016/J.Neuroscience.2006.03.075  0.49
2006 Brinton RD, Wang JM. Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease. Current Alzheimer Research. 3: 11-7. PMID 16472197 DOI: 10.2174/156720506775697160  0.378
2006 Mishra A, Yin F, Mao Z, Shang Y, Do L, Trouard TP, Brinton RD. P2-204: SEX DIFFERENCES IN METABOLIC AND INFLAMMATORY AGING OF THE BRAIN IN HUMANIZED APOE-ε4 KNOCK-IN RATS Alzheimer's & Dementia. 14: P746-P747. DOI: 10.1016/J.Jalz.2018.06.892  0.348
2006 Chen S, Kumar N, Mao Z, Wang T, Sitruk-Ware R, Brinton RD. P2-165: THERAPEUTIC PROGESTIN NESTORONE PROMOTES NEUROGENESIS: IMPLICATIONS FOR SUSTAINING REGENERATION IN FEMALE BRAIN Alzheimer's & Dementia. 14: P732-P732. DOI: 10.1016/j.jalz.2018.06.852  0.344
2006 Desai MK, Irwin RW, Prajapati M, Pathak KV, McGilvrey M, Pirrotte P, Brinton RD. P2-129: ALLOPREGNANOLONE RESTORES COGNITIVE FUNCTION IN APOE4+ FEMALES AND MALES AND PROMOTES METABOLISM OF FUELS REQUIRED FOR ATP GENERATION Alzheimer's & Dementia. 14: P717-P718. DOI: 10.1016/J.Jalz.2018.06.815  0.636
2006 Mao Z, Yin F, Yao J, Brinton RD. P3-147: RESPONSE TO HORMONAL INTERVENTION IN AGING FEMALE BRAIN IS ENDOCRINE STATUS DEPENDENT: IMPLICATIONS FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1124-P1124. DOI: 10.1016/J.Jalz.2018.06.1504  0.558
2006 Yin F, Shang Y, Berghout J, Lussier Y, Brinton RD. P3-133: A BIOENERGETIC-INFLAMMATORY TRANSITION STATE CHARACTERIZES PERIMENOPAUSAL AGING BRAIN AND INDICATES ALZHEIMER'S VULNERABILITY Alzheimer's & Dementia. 14: P1118-P1119. DOI: 10.1016/J.Jalz.2018.06.1490  0.367
2006 Hernandez GD, Lopez C, Desai MK, Kono N, Irwin RW, Rodgers KE, Mack WJ, Rogawski MA, Schneider LS, Brinton RD. P1-053: PHARMACOKINETICS AND SAFETY PROFILE OF INTRAVENOUS ADMINISTRATION OF ALLOPREGNANOLONE IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P288-P288. DOI: 10.1016/J.Jalz.2018.06.055  0.65
2006 Nilsen J, Irwin RW, Brinton RD. P4-390: Brain mitochondria as therapeutic target for the prevention of Alzheimers pathology Alzheimer's & Dementia. 2: S632-S633. DOI: 10.1016/J.Jalz.2006.05.2131  0.757
2006 Brinton RD, Wang JM, Irwin R, Liu L, Chen S, Wu T. P4-350: Promotion of neurogenesis in the triple transgenic Alzheimer's mouse dentate gyrus and subventricular zone by the neurosteroid allopregnanolone Alzheimer's & Dementia. 2: S620-S620. DOI: 10.1016/J.Jalz.2006.05.2091  0.794
2005 Nilsen J, Deng J, Brinton RD. Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involved. Drug News & Perspectives. 18: 545-53. PMID 16421627 DOI: 10.1358/dnp.2005.18.9.948450  0.617
2005 Wu TW, Wang JM, Chen S, Brinton RD. 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Neuroscience. 135: 59-72. PMID 16084662 DOI: 10.1016/j.neuroscience.2004.12.027  0.507
2005 Lowell J, Vazquez MC, Swerdlow R, Khan S, Fagan T, David D, Nilsen J, Smigrodzki R, Reddy PH, Leski M, Brinton RD, Pugh M. Alzheimer Research Forum Live Discussion: A "Mitochondrial Cascade Hypothesis" for sporadic Alzheimer's disease Journal of Alzheimer's Disease. 8: 311-315. DOI: 10.3233/Jad-2005-8310  0.641
2004 Nilsen J, Brinton RD. Mitochondria as therapeutic targets of estrogen action in the central nervous system. Current Drug Targets. Cns and Neurological Disorders. 3: 297-313. PMID 15379606 DOI: 10.2174/1568007043337193  0.648
2004 Zhao L, Wu TW, Brinton RD. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Brain Research. 1010: 22-34. PMID 15126114 DOI: 10.1016/J.Brainres.2004.02.066  0.537
2004 Zhao L, Brinton RD. Suppression of proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha in astrocytes by a V1 vasopressin receptor agonist: a cAMP response element-binding protein-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2226-35. PMID 14999073 DOI: 10.1523/Jneurosci.4922-03.2004  0.514
2004 O'Neill K, Chen S, Brinton RD. Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease. Experimental Neurology. 185: 63-80. PMID 14697319 DOI: 10.1016/j.expneurol.2003.09.005  0.313
2004 Brinton RD, Nilsen J. P1-426 Divergent impact of progestins in vitro predicts Alzheimer's disease risk in women using hormone therapy Neurobiology of Aging. 25: S220. DOI: 10.1016/S0197-4580(04)80738-3  0.631
2004 Nilsen J, Brinton RD. P1-355 Estrogen regulates mitochondrial function: mechanisms for protection against degenerative insults Neurobiology of Aging. 25: S199. DOI: 10.1016/S0197-4580(04)80667-5  0.618
2003 Alt J, Angst J, Backstrom T, Baulieu EE, Berga S, Birkhaeuser MH, Bixler EO, Brincat M, Brinton RD, Bryant H, Canonico P, Cassano GB, Da Silva I, Dell'Osso L, Drago F, et al. Hormone replacement therapy in climacteric and aging brain Gynecological Endocrinology. 17: 363-378. PMID 14710584 DOI: 10.1080/09513590312331290258  0.414
2003 Brinton RD, Nilsen J. Effects of estrogen plus progestin on risk of dementia. Jama. 290: 1706; author reply 1. PMID 14519699 DOI: 10.1001/Jama.290.13.1706-A  0.587
2003 Nilsen J, Brinton RD. Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 100: 10506-11. PMID 12925744 DOI: 10.1073/pnas.1334098100  0.609
2003 Zhao L, Chen S, Brinton RD. An estrogen replacement therapy containing nine synthetic plant-based conjugated estrogens promotes neuronal survival. Experimental Biology and Medicine (Maywood, N.J.). 228: 823-35. PMID 12876302 DOI: 10.1177/15353702-0322807-08  0.581
2003 Zhao L, Brinton RD. Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4228-39. PMID 12764111 DOI: 10.1523/Jneurosci.23-10-04228.2003  0.501
2002 Zhao L, Brinton RD. Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes. Brain Research. 943: 117-31. PMID 12088846 DOI: 10.1016/S0006-8993(02)02484-8  0.499
2002 Nilsen J, Brinton RD. Impact of progestins on estradiol potentiation of the glutamate calcium response. Neuroreport. 13: 825-30. PMID 11997695 DOI: 10.1097/00001756-200205070-00018  0.601
2002 Nilsen J, Chen S, Brinton RD. Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway. Brain Research. 930: 216-34. PMID 11879813 DOI: 10.1016/S0006-8993(02)02254-0  0.591
2002 Nilsen J, Brinton RD. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology. 143: 205-12. PMID 11751611 DOI: 10.1210/endo.143.1.8582  0.643
2001 Son MC, Brinton RD. Regulation and mechanism of L-type calcium channel activation via V1a vasopressin receptor activation in cultured cortical neurons. Neurobiology of Learning and Memory. 76: 388-402. PMID 11726244 DOI: 10.1006/Nlme.2001.4020  0.577
1998 Son MC, Brinton RD. Vasopressin-induced calcium signaling in cultured cortical neurons. Brain Research. 793: 244-54. PMID 9630655 DOI: 10.1016/S0006-8993(98)00185-1  0.596
1998 Brinton RD, Yamazaki R, Gonzalez CM, O'Neill K, Schreiber SS. Vasopressin-induction of the immediate early gene, NGFI-A, in cultured hippocampal glial cells. Brain Research. Molecular Brain Research. 57: 73-85. PMID 9630527 DOI: 10.1016/S0169-328X(98)00069-2  0.313
1988 McEwen B, Chao H, Spencer R, Brinton R, Macisaac L, Harrelson A. Corticosteroid receptors in brain: relationship of receptors to effects in stress and aging. Annals of the New York Academy of Sciences. 512: 394-401. PMID 3327425 DOI: 10.1111/J.1749-6632.1987.Tb24975.X  0.609
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