Roberta Diaz Brinton - Publications

Affiliations: 
University of Southern California, Los Angeles, CA, United States 

152 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Schneider LS, Hernandez G, Zhao L, Franke AA, Chen YL, Pawluczyk S, Mack WJ, Brinton RD. Safety and feasibility of estrogen receptor-β targeted phytoSERM formulation for menopausal symptoms: phase 1b/2a randomized clinical trial. Menopause (New York, N.Y.). PMID 30889096 DOI: 10.1097/GME.0000000000001325  1
2018 Karim R, Koc M, Rettberg JR, Hodis HN, Henderson VW, St John JA, Allayee H, Brinton RD, Mack WJ. Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease. Menopause (New York, N.Y.). PMID 29975287 DOI: 10.1097/GME.0000000000001160  1
2017 Hernandez G, Zhao L, Franke AA, Chen YL, Mack WJ, Brinton RD, Schneider LS. Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor β-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause (New York, N.Y.). PMID 28926513 DOI: 10.1097/GME.0000000000000984  1
2017 Yin F, Yao J, Brinton RD, Cadenas E. Editorial: The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration. Frontiers in Aging Neuroscience. 9: 209. PMID 28701949 DOI: 10.3389/fnagi.2017.00209  1
2016 Karim R, Dang H, Henderson VW, Hodis HN, St John J, Brinton RD, Mack WJ. Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life. Journal of the American Geriatrics Society. 64: 2448-2456. PMID 27996108 DOI: 10.1111/jgs.14658  0.76
2016 Wang Y, Brinton RD. Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex. Frontiers in Aging Neuroscience. 8: 232. PMID 27757081 DOI: 10.3389/fnagi.2016.00232  1
2016 Zhao L, Mao Z, Woody SK, Brinton RD. Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease. Neurobiology of Aging. 42: 69-79. PMID 27143423 DOI: 10.1016/j.neurobiolaging.2016.02.011  0.6
2016 Rettberg JR, Dang H, Hodis HN, Henderson VW, St John JA, Mack WJ, Brinton RD. Identifying postmenopausal women at risk for cognitive decline within a healthy cohort using a panel of clinical metabolic indicators: potential for detecting an at-Alzheimer's risk metabolic phenotype. Neurobiology of Aging. 40: 155-63. PMID 26973115 DOI: 10.1016/j.neurobiolaging.2016.01.011  1
2015 Klosinski LP, Yao J, Yin F, Fonteh AN, Harrington MG, Christensen TA, Trushina E, Brinton RD. White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease. Ebiomedicine. 2: 1888-904. PMID 26844268 DOI: 10.1016/j.ebiom.2015.11.002  1
2015 Espeland MA, Brinton RD, Hugenschmidt C, Manson JE, Craft S, Yaffe K, Weitlauf J, Vaughan L, Johnson KC, Padula CB, Jackson RD, Resnick SM. Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women. Diabetes Care. PMID 26486190 DOI: 10.2337/dc15-1385  0.6
2015 Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology. 85: 1131-8. PMID 26163429 DOI: 10.1212/WNL.0000000000001816  0.6
2015 Irwin RW, Solinsky CM, Loya CM, Salituro FG, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease. Plos One. 10: e0128313. PMID 26039057 DOI: 10.1371/journal.pone.0128313  1
2015 Brinton RD, Yao J, Yin F, Mack WJ, Cadenas E. Perimenopause as a neurological transition state. Nature Reviews. Endocrinology. 11: 393-405. PMID 26007613 DOI: 10.1038/nrendo.2015.82  1
2015 Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiology of Aging. 36: 2282-95. PMID 25921624 DOI: 10.1016/j.neurobiolaging.2015.03.013  1
2015 Caldwell CC, Yao J, Brinton RD. Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 66-80. PMID 25534394 DOI: 10.1007/s13311-014-0324-8  1
2015 Karim R, Stanczyk FZ, Brinton RD, Rettberg J, Hodis HN, Mack WJ. Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women. The Journal of Clinical Endocrinology and Metabolism. 100: 508-15. PMID 25405497 DOI: 10.1210/jc.2014-1839  1
2015 Klosinski LP, Yao J, Yin F, Fonteh AN, Harrington MG, Christensen TA, Trushina E, Brinton RD. White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease Ebiomedicine. DOI: 10.1016/j.ebiom.2015.11.002  0.6
2014 Irwin RW, Solinsky CM, Brinton RD. Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders. Frontiers in Cellular Neuroscience. 8: 203. PMID 25126056 DOI: 10.3389/fncel.2014.00203  1
2014 Irwin RW, Brinton RD. Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise. Progress in Neurobiology. 113: 40-55. PMID 24044981 DOI: 10.1016/j.pneurobio.2013.08.004  1
2014 Rettberg JR, Yao J, Brinton RD. Estrogen: a master regulator of bioenergetic systems in the brain and body. Frontiers in Neuroendocrinology. 35: 8-30. PMID 23994581 DOI: 10.1016/j.yfrne.2013.08.001  1
2014 Sancheti H, Akopian G, Yin F, Brinton RD, Walsh JP. Correction: Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease Plos One. 9. DOI: 10.1371/journal.pone.0116442  1
2013 Ding F, Yao J, Rettberg JR, Chen S, Brinton RD. Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention. Plos One. 8: e79977. PMID 24244584 DOI: 10.1371/journal.pone.0079977  1
2013 Fuente-Martin E, Garcia-Caceres C, Morselli E, Clegg DJ, Chowen JA, Finan B, Brinton RD, Tschöp MH. Estrogen, astrocytes and the neuroendocrine control of metabolism. Reviews in Endocrine & Metabolic Disorders. 14: 331-8. PMID 24009071 DOI: 10.1007/s11154-013-9263-7  1
2013 Zhao L, Mao Z, Chen S, Schneider LS, Brinton RD. Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 37: 403-19. PMID 23948892 DOI: 10.3233/JAD-122341  1
2013 Sancheti H, Akopian G, Yin F, Brinton RD, Walsh JP, Cadenas E. Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. Plos One. 8: e69830. PMID 23875003 DOI: 10.1371/journal.pone.0069830  1
2013 Jiang T, Yin F, Yao J, Brinton RD, Cadenas E. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway. Aging Cell. 12: 1021-31. PMID 23815272 DOI: 10.1111/acel.12127  1
2013 Singh M, Simpkins JW, Simpkins JW, Bimonte-Nelson HA, Bimonte-Nelson HA, Brinton RD, Brinton RD. Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease. Brain Research. 1514: 1-2. PMID 23726132 DOI: 10.1016/j.brainres.2013.04.044  1
2013 Ding F, Yao J, Zhao L, Mao Z, Chen S, Brinton RD. Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's. Plos One. 8: e59825. PMID 23555795 DOI: 10.1371/journal.pone.0059825  1
2013 Brinton RD. Neurosteroids as regenerative agents in the brain: therapeutic implications. Nature Reviews. Endocrinology. 9: 241-50. PMID 23438839 DOI: 10.1038/nrendo.2013.31  1
2013 Yao J, Zhao L, Mao Z, Chen S, Wong KC, To J, Brinton RD. Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments. Brain Research. 1514: 128-41. PMID 23428542 DOI: 10.1016/j.brainres.2013.02.021  1
2012 Adeosun SO, Hou X, Jiao Y, Zheng B, Henry S, Hill R, He Z, Pani A, Kyle P, Ou X, Mosley T, Farley JM, Stockmeier C, Paul I, Bigler S, ... Brinton RD, et al. Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. Plos One. 7: e50040. PMID 23209637 DOI: 10.1371/journal.pone.0050040  1
2012 Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ. 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology. 153: 5467-79. PMID 22962256 DOI: 10.1210/en.2012-1464  1
2012 Yao J, Brinton RD. Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease. Advances in Pharmacology (San Diego, Calif.). 64: 327-71. PMID 22840752 DOI: 10.1016/B978-0-12-394816-8.00010-6  1
2012 Brinton RD. Minireview: Translational animal models of human menopause: Challenges and emerging opportunities Endocrinology. 153: 3571-3578. PMID 22778227 DOI: 10.1210/en.2012-1340  1
2012 Reiman EM, Brinton RD, Katz R, Petersen RC, Negash S, Mungas D, Aisen PS. Considerations in the design of clinical trials for cognitive aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 766-72. PMID 22573913 DOI: 10.1093/gerona/gls124  1
2012 Wang JM, Hou X, Adeosun S, Hill R, Henry S, Paul I, Irwin RW, Ou XM, Bigler S, Stockmeier C, Brinton RD, Gomez-Sanchez E. A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats. Plos One. 7: e33493. PMID 22428062 DOI: 10.1371/journal.pone.0033493  1
2012 Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. Plos One. 7: e31267. PMID 22393359 DOI: 10.1371/journal.pone.0031267  1
2012 Sun C, Ou X, Farley JM, Stockmeier C, Bigler S, Brinton RD, Wang JM. Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease. Current Alzheimer Research. 9: 473-80. PMID 22272610  1
2012 Bali N, Arimoto JM, Iwata N, Lin SW, Zhao L, Brinton RD, Morgan TE, Finch CE. Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis. Endocrinology. 153: 759-69. PMID 22147012 DOI: 10.1210/en.2011-1699  1
2012 Irwin RW, Yao J, To J, Hamilton RT, Cadenas E, Brinton RD. Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function. Journal of Neuroendocrinology. 24: 236-48. PMID 22070562 DOI: 10.1111/j.1365-2826.2011.02251.x  1
2012 Singh C, Liu L, Wang JM, Irwin RW, Yao J, Chen S, Henry S, Thompson RF, Brinton RD. Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice. Neurobiology of Aging. 33: 1493-506. PMID 21803451 DOI: 10.1016/j.neurobiolaging.2011.06.008  1
2012 Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, Brinton RD. Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid. Neurobiology of Aging. 33: 1507-21. PMID 21514693 DOI: 10.1016/j.neurobiolaging.2011.03.001  1
2011 Irwin RW, Wang JM, Chen S, Brinton RD. Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. Frontiers in Endocrinology. 2: 117. PMID 22654847 DOI: 10.3389/fendo.2011.00117  1
2011 Yao J, Rettberg JR, Klosinski LP, Cadenas E, Brinton RD. Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Molecular Aspects of Medicine. 32: 247-57. PMID 22024249 DOI: 10.1016/j.mam.2011.10.005  1
2011 Chen S, Wang JM, Irwin RW, Yao J, Liu L, Brinton RD. Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. Plos One. 6: e24293. PMID 21918687 DOI: 10.1371/journal.pone.0024293  1
2011 Yao J, Brinton RD. Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment. Current Pharmaceutical Design. 17: 3474-9. PMID 21902662 DOI: 10.2174/138161211798072517  1
2011 Yao J, Chen S, Mao Z, Cadenas E, Brinton RD. 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. Plos One. 6: e21788. PMID 21747957 DOI: 10.1371/journal.pone.0021788  1
2011 Zhao L, Mao Z, Schneider LS, Brinton RD. Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause. Menopause (New York, N.Y.). 18: 1131-42. PMID 21738079 DOI: 10.1097/gme.0b013e3182175b66  1
2011 Clarkson TB, Utian WH, Barnes S, Gold EB, Basaria SS, Aso T, Kronenberg F, Frankenfeld CL, Cline JMA, Landgren BM, Gallagher JC, Weaver CM, Hodis HN, Brinton RD, Maki PM, et al. The role of soy isoflavones in menopausal health: Report of the North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010) Menopause. 18: 732-753. PMID 21685820 DOI: 10.1097/gme.0b013e31821fc8e0  1
2011 Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Research. 1379: 11-22. PMID 21241683 DOI: 10.1016/j.brainres.2011.01.029  1
2011 Wu TW, Chen S, Brinton RD. Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons. Brain Research. 1379: 34-43. PMID 21241678 DOI: 10.1016/j.brainres.2011.01.034  1
2011 Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Research. 1379: 23-33. PMID 21238431 DOI: 10.1016/j.brainres.2011.01.012  1
2011 Irwin RW, Yao J, Ahmed SS, Hamilton RT, Cadenas E, Brinton RD. Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology. 152: 556-67. PMID 21159850 DOI: 10.1210/en.2010-1061  1
2011 Yao J, Chen S, Cadenas E, Brinton RD. Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone. Brain Research. 1379: 2-10. PMID 21134358 DOI: 10.1016/j.brainres.2010.11.090  1
2011 Zhao L, Yao J, Mao Z, Chen S, Wang Y, Brinton RD. 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiology of Aging. 32: 1949-63. PMID 20053478 DOI: 10.1016/j.neurobiolaging.2009.12.010  1
2011 Foy MR, Baudry M, Brinton RD, Thompson RF. Estrogen, progesterone and hippocampal plasticity in rodent models Advances in Alzheimer's Disease. 1: 109-127. DOI: 10.3233/978-1-60750-733-8-109  1
2011 Liu L, Brinton RD. Gonadal Hormones, Neurosteroids, and Clinical Progestins as Neurogenic Regenerative Agents: Therapeutic Implications Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis. 281-303. DOI: 10.1002/9783527633968.ch17  1
2010 Liu L, Zhao L, She H, Chen S, Wang JM, Wong C, McClure K, Sitruk-Ware R, Brinton RD. Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo. Endocrinology. 151: 5782-94. PMID 20943809 DOI: 10.1210/en.2010-0005  1
2010 Henderson VW, Brinton RD. Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy. Progress in Brain Research. 182: 77-96. PMID 20541661 DOI: 10.1016/S0079-6123(10)82003-5  1
2010 Yao J, Hamilton RT, Cadenas E, Brinton RD. Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Biochimica Et Biophysica Acta. 1800: 1121-6. PMID 20538040 DOI: 10.1016/j.bbagen.2010.06.002  1
2010 Wang JM, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 6498-503. PMID 20231471 DOI: 10.1073/pnas.1001422107  1
2010 Wang M, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 14, (6498-6503) DOI: 10.1073/pnas. 1001422107) Proceedings of the National Academy of Sciences of the United States of America. 107: 11145. DOI: 10.1073/pnas.1006236107  1
2010 Brinton RD. Neuroendocrinology of Aging Brocklehurst's Textbook of Geriatric Medicine and Gerontology. 163-169. DOI: 10.1016/B978-1-4160-6231-8.10027-3  1
2010 Brinton RD, Gore AC, Schmidt PJ, Morrison JH. Reproductive aging of females: Neural systems Hormones, Brain and Behavior Online. 2199-2224. DOI: 10.1016/B978-008088783-8.00068-1  1
2009 Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 14670-5. PMID 19667196 DOI: 10.1073/pnas.0903563106  1
2009 Liu L, Wang J, Zhao L, Nilsen J, McClure K, Wong K, Brinton RD. Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2. Endocrinology. 150: 3186-96. PMID 19359388 DOI: 10.1210/en.2008-1447  1
2009 Brinton RD. Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends in Pharmacological Sciences. 30: 212-22. PMID 19299024 DOI: 10.1016/j.tips.2008.12.006  1
2009 Asthana S, Brinton RD, Henderson VW, McEwen BS, Morrison JH, Schmidt PJ. Frontiers proposal. National Institute on Aging "bench to bedside: estrogen as a case study". Age (Dordrecht, Netherlands). 31: 199-210. PMID 19277902 DOI: 10.1007/s11357-009-9087-2  1
2009 Zhao L, Mao Z, Brinton RD. A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. Endocrinology. 150: 770-83. PMID 18818291 DOI: 10.1210/en.2008-0715  1
2009 Hogervorst E, Henderson VW, Gibbs RB, Brinton RD. Concluding remarks Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. 271-274. DOI: 10.1017/CBO9780511635700.030  1
2009 Zhao L, Brinton RD. In search of estrogen alternatives for the brain Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. 93-100. DOI: 10.1017/CBO9780511635700.011  1
2009 Brinton RD. The healthy cell bias of estrogen action through regulating glucose metabolism and mitochondrial function: Implications for prevention of Alzheimer's disease Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. 55-64. DOI: 10.1017/CBO9780511635700.007  1
2009 Hogervorst E, Henderson VW, Gibbs RB, Brinton RD. Hormones, Cognition and Dementia: State of the art and emergent therapeutic strategies Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. 1-282. DOI: 10.1017/CBO9780511635700  1
2008 Wang JM, Brinton RD. Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential. Bmc Neuroscience. 9: S11. PMID 19090984 DOI: 10.1186/1471-2202-9-S2-S11  1
2008 Brinton RD. The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications. Trends in Neurosciences. 31: 529-37. PMID 18774188 DOI: 10.1016/j.tins.2008.07.003  1
2008 Brinton RD. Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease. Advanced Drug Delivery Reviews. 60: 1504-11. PMID 18647624 DOI: 10.1016/j.addr.2008.06.003  1
2008 Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J. Progesterone receptors: form and function in brain. Frontiers in Neuroendocrinology. 29: 313-39. PMID 18374402 DOI: 10.1016/j.yfrne.2008.02.001  1
2008 Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology. 149: 3167-75. PMID 18292191 DOI: 10.1210/en.2007-1227  1
2008 Wang JM, Liu L, Brinton RD. Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway. Endocrinology. 149: 208-18. PMID 17962344 DOI: 10.1210/en.2007-1155  1
2008 Wang JM, Liu L, Irwin RW, Chen S, Brinton RD. Regenerative potential of allopregnanolone. Brain Research Reviews. 57: 398-409. PMID 17931704 DOI: 10.1016/j.brainresrev.2007.08.010  1
2007 Wang JM, Irwin RW, Liu L, Chen S, Brinton RD. Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent. Current Alzheimer Research. 4: 510-7. PMID 18220513 DOI: 10.2174/156720507783018262  1
2007 Nilsen J, Irwin RW, Gallaher TK, Brinton RD. Estradiol in vivo regulation of brain mitochondrial proteome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14069-77. PMID 18094246 DOI: 10.1523/JNEUROSCI.4391-07.2007  1
2007 Zhao L, Brinton RD. WHI and WHIMS follow-up and human studies of soy isoflavones on cognition. Expert Review of Neurotherapeutics. 7: 1549-64. PMID 17997703 DOI: 10.1586/14737175.7.11.1549  1
2007 Brinton RD. Building a neuroscience legacy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11163-6. PMID 17942709 DOI: 10.1523/JNEUROSCI.4208-07.2007  1
2007 Zhao L, Brinton RD. Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons. Brain Research. 1172: 48-59. PMID 17803971 DOI: 10.1016/j.brainres.2007.06.092  1
2007 Zhao L, Jin C, Mao Z, Gopinathan MB, Rehder K, Brinton RD. Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons. Journal of Medicinal Chemistry. 50: 4471-81. PMID 17696335 DOI: 10.1021/jm070546x  1
2007 Soussou WV, Yoon GJ, Brinton RD, Berger TW. Neuronal network morphology and electrophysiologyof hippocampal neurons cultured on surface-treated multielectrode arrays. Ieee Transactions On Bio-Medical Engineering. 54: 1309-20. PMID 17605362 DOI: 10.1109/TBME.2006.889195  1
2006 Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. Bmc Neuroscience. 7: 74. PMID 17083736 DOI: 10.1186/1471-2202-7-74  1
2006 Wang JM, Irwin RW, Brinton RD. Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 16983-8. PMID 17077142 DOI: 10.1073/pnas.0608128103  1
2006 Morrison JH, Brinton RD, Schmidt PJ, Gore AC. Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10332-48. PMID 17035515 DOI: 10.1523/JNEUROSCI.3369-06.2006  1
2006 Mannella P, Brinton RD. Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9439-47. PMID 16971528 DOI: 10.1523/JNEUROSCI.1443-06.2006  1
2006 Zhao L, O'Neill K, Brinton RD. Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. The Journal of Pharmacology and Experimental Therapeutics. 319: 1124-32. PMID 16951259 DOI: 10.1124/jpet.106.109504  1
2006 Chen S, Nilsen J, Brinton RD. Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications. Endocrinology. 147: 5303-13. PMID 16916950 DOI: 10.1210/en.2006-0495  1
2006 Nilsen J, Morales A, Brinton RD. Medroxyprogesterone acetate exacerbates glutamate excitotoxicity. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology. 22: 355-61. PMID 16864144 DOI: 10.1080/09513590600863337  1
2006 Brinton RD, Wang JM. Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent. Current Alzheimer Research. 3: 185-90. PMID 16842093 DOI: 10.2174/156720506777632817  1
2006 Kim MT, Soussou W, Gholmieh G, Ahuja A, Tanguay A, Berger TW, Brinton RD. 17beta-Estradiol potentiates field excitatory postsynaptic potentials within each subfield of the hippocampus with greatest potentiation of the associational/commissural afferents of CA3. Neuroscience. 141: 391-406. PMID 16725270 DOI: 10.1016/j.neuroscience.2006.03.075  1
2006 Zhao L, Brinton RD. Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease. Bmc Neuroscience. 7: 24. PMID 16533397 DOI: 10.1186/1471-2202-7-24  1
2006 Brinton RD, Wang JM. Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease. Current Alzheimer Research. 3: 11-7. PMID 16472197 DOI: 10.2174/156720506775697160  1
2006 Brewer GJ, Reichensperger JD, Brinton RD. Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. Neurobiology of Aging. 27: 306-17. PMID 15961189 DOI: 10.1016/j.neurobiolaging.2005.01.019  1
2006 Brinton RD, Zhao L. Preclinical efforts to develop effective NeuroSERMs for the Brain The Effects of Estrogen On Brain Function. 116-143.  1
2005 Nilsen J, Deng J, Brinton RD. Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involved. Drug News & Perspectives. 18: 545-53. PMID 16421627 DOI: 10.1358/dnp.2005.18.9.948450  1
2005 Cocozza JD, Brinton RD. Turning students into science stars. Ieee Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society. 24: 82-91. PMID 16248121 DOI: 10.1109/MEMB.2005.1511504  1
2005 Wu TW, Wang JM, Chen S, Brinton RD. 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Neuroscience. 135: 59-72. PMID 16084662 DOI: 10.1016/j.neuroscience.2004.12.027  1
2005 Brinton RD. Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action. Annals of the New York Academy of Sciences. 1052: 57-74. PMID 16024751 DOI: 10.1196/annals.1347.005  1
2005 Wang JM, Johnston PB, Ball BG, Brinton RD. The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4706-18. PMID 15888646 DOI: 10.1523/JNEUROSCI.4520-04.2005  1
2005 Zhao L, Brinton RD. Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. Journal of Medicinal Chemistry. 48: 3463-6. PMID 15887952 DOI: 10.1021/jm0490538  1
2005 Zhao L, Chen S, Ming Wang J, Brinton RD. 17beta-estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: a potential initiation mechanism for estrogen neurotrophism. Neuroscience. 132: 299-311. PMID 15802184 DOI: 10.1016/j.neuroscience.2004.11.054  1
2005 Zhao L, Brinton RD. Estrogen receptor β as a therapeutic target for promoting neurogenesis and preventing neurodegeneration Drug Development Research. 66: 103-117. DOI: 10.1002/ddr.20049  1
2005 Lowell J, Vazquez MC, Swerdlow R, Khan S, Fagan T, David D, Nilsen J, Smigrodzki R, Reddy PH, Leski M, Brinton RD, Pugh M. Alzheimer Research Forum Live Discussion: A "Mitochondrial Cascade Hypothesis" for sporadic Alzheimer's disease Journal of Alzheimer's Disease. 8: 311-315.  1
2004 Brinton RD. Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERM. Journal of Alzheimer's Disease : Jad. 6: S27-35. PMID 15665410  1
2004 Nilsen J, Brinton RD. Mitochondria as therapeutic targets of estrogen action in the central nervous system. Current Drug Targets. Cns and Neurological Disorders. 3: 297-313. PMID 15379606 DOI: 10.2174/1568007043337193  1
2004 O'Neill K, Chen S, Diaz Brinton R. Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease. Experimental Neurology. 188: 268-78. PMID 15246826 DOI: 10.1016/j.expneurol.2004.01.014  1
2004 Brinton RD. Impact of estrogen therapy on Alzheimer's disease: a fork in the road? Cns Drugs. 18: 405-22. PMID 15139797 DOI: 10.2165/00023210-200418070-00001  1
2004 Zhao L, Wu TW, Brinton RD. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Brain Research. 1010: 22-34. PMID 15126114 DOI: 10.1016/j.brainres.2004.02.066  1
2004 Zhao L, Brinton RD. Suppression of proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha in astrocytes by a V1 vasopressin receptor agonist: a cAMP response element-binding protein-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2226-35. PMID 14999073 DOI: 10.1523/JNEUROSCI.4922-03.2004  1
2004 O'Neill K, Chen S, Brinton RD. Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease. Experimental Neurology. 185: 63-80. PMID 14697319 DOI: 10.1016/j.expneurol.2003.09.005  1
2003 Alt J, Angst J, Backstrom T, Baulieu EE, Berga S, Birkhaeuser MH, Bixler EO, Brincat M, Brinton RD, Bryant H, Canonico P, Cassano GB, Da Silva I, Dell'Osso L, Drago F, et al. Hormone replacement therapy in climacteric and aging brain Gynecological Endocrinology. 17: 363-378. PMID 14710584 DOI: 10.1080/09513590312331290258  1
2003 Brinton RD, Nilsen J. Effects of estrogen plus progestin on risk of dementia. Jama. 290: 1706; author reply 1. PMID 14519699 DOI: 10.1001/jama.290.13.1706-a  1
2003 Nilsen J, Brinton RD. Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 100: 10506-11. PMID 12925744 DOI: 10.1073/pnas.1334098100  1
2003 Zhao L, Chen S, Brinton RD. An estrogen replacement therapy containing nine synthetic plant-based conjugated estrogens promotes neuronal survival. Experimental Biology and Medicine (Maywood, N.J.). 228: 823-35. PMID 12876302  1
2003 Zhao L, Brinton RD. Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4228-39. PMID 12764111  1
2003 Nilsen J, Diaz Brinton R. Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression. Proceedings of the National Academy of Sciences of the United States of America. 100: 2842-7. PMID 12604781 DOI: 10.1073/pnas.0438041100  1
2002 Brownson EA, Brinton RD, Chambers KC. Vasopressin content in select brain regions during extinction of a conditioned taste aversion. Brain Research Bulletin. 59: 125-34. PMID 12379443 DOI: 10.1016/S0361-9230(02)00861-4  1
2002 Zhao L, Chen Q, Diaz Brinton R. Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Experimental Biology and Medicine (Maywood, N.J.). 227: 509-19. PMID 12094016  1
2002 Zhao L, Brinton RD. Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes. Brain Research. 943: 117-31. PMID 12088846 DOI: 10.1016/S0006-8993(02)02484-8  1
2002 Nilsen J, Brinton RD. Impact of progestins on estradiol potentiation of the glutamate calcium response. Neuroreport. 13: 825-30. PMID 11997695  1
2002 Nilsen J, Chen S, Brinton RD. Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway. Brain Research. 930: 216-34. PMID 11879813 DOI: 10.1016/S0006-8993(02)02254-0  1
2002 Nilsen J, Brinton RD. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology. 143: 205-12. PMID 11751611 DOI: 10.1210/endo.143.1.8582  1
2002 Brinton RD. Selective estrogen receptor modulators (SERM) for the brain: Recent advances and remaining challenges for developing a NeuroSERM™ Drug Development Research. 56: 380-392. DOI: 10.1002/ddr.10090  1
2001 Son MC, Brinton RD. Regulation and mechanism of L-type calcium channel activation via V1a vasopressin receptor activation in cultured cortical neurons. Neurobiology of Learning and Memory. 76: 388-402. PMID 11726244 DOI: 10.1006/nlme.2001.4020  1
2001 Brinton RD. Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges. Learning & Memory (Cold Spring Harbor, N.Y.). 8: 121-33. PMID 11390632 DOI: 10.1101/lm.39601  1
2000 Chen Q, Patel R, Sales A, Oji G, Kim J, Monreal AW, Brinton RD. Vasopressin-induced neurotrophism in cultured neurons of the cerebral cortex: dependency on calcium signaling and protein kinase C activity. Neuroscience. 101: 19-26. PMID 11068133 DOI: 10.1016/S0306-4522(00)00323-7  1
2000 Brinton RD, Thompson RH, Brownson EA. Spatial, cellular and temporal basis of vasopressin potentiation of norepinephrine-induced cAMP formation. European Journal of Pharmacology. 405: 73-88. PMID 11033316 DOI: 10.1016/S0014-2999(00)00543-4  1
2000 Chen Q, Schreiber SS, Brinton RD. Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Neuropeptides. 34: 173-80. PMID 11021977 DOI: 10.1054/npep.2000.0809  1
2000 Brinton RD, Chen S, Montoya M, Hsieh D, Minaya J. The estrogen replacement therapy of the Women's Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer's disease. Maturitas. 34: S35-52. PMID 10915920 DOI: 10.1016/S0378-5122(00)00107-9  1
1999 Brinton RD. A women's health issue: Alzheimer's disease and strategies for maintaining cognitive health. International Journal of Fertility and Women's Medicine. 44: 174-85. PMID 10499738  1
1999 Davies DL, Bolger MB, Brinton RD, Finn DA, Alkana RL. In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol. Psychopharmacology. 141: 339-50. PMID 10090641 DOI: 10.1007/s002130050843  1
1999 Foy MR, Xu J, Xie X, Brinton RD, Thompson RF, Berger TW. 17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. Journal of Neurophysiology. 81: 925-9. PMID 10036289  1
1998 Brinton RD, Yamazaki RS, Chen Q, Son M. Vasopressin action in the mammalian cerebral cortex. Advances in Experimental Medicine and Biology. 449: 211-3. PMID 10026807  1
1998 Son MC, Brinton RD. Vasopressin-induced calcium signaling in cultured cortical neurons. Brain Research. 793: 244-54. PMID 9630655 DOI: 10.1016/S0006-8993(98)00185-1  1
1998 Brinton RD, Yamazaki R, Gonzalez CM, O'Neill K, Schreiber SS. Vasopressin-induction of the immediate early gene, NGFI-A, in cultured hippocampal glial cells. Brain Research. Molecular Brain Research. 57: 73-85. PMID 9630527 DOI: 10.1016/S0169-328X(98)00069-2  1
1998 Brinton RD, Yamazaki RS. Advances and challenges in the prevention and treatment of Alzheimer's disease Pharmaceutical Research. 15: 386-398. PMID 9563067 DOI: 10.1023/A:1011963929012  1
1998 Brinton RD, Chen S, Zhang S, Lorient V, Manaya J, Kim J, Oji G. Comparative analysis of conjugated equine estrogens and the serm raloxifene on outgrowth and survival of neurons critical to memory function and adversely affected in alzheimer's disease International Journal of Fertility and Menopausal Studies. 43: 223.  1
1997 Brinton RD, Tran J, Proffitt P, Montoya M. 17 beta-Estradiol enhances the outgrowth and survival of neocortical neurons in culture. Neurochemical Research. 22: 1339-51. PMID 9355106 DOI: 10.1023/A:1022015005508  1
1997 Brinton RD, Proffitt P, Tran J, Luu R. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Experimental Neurology. 147: 211-20. PMID 9344546 DOI: 10.1006/exnr.1997.6619  1
1997 Yamazaki RS, Chen Q, Schreiber SS, Brinton RD. Localization of V1a vasopressin receptor mRNA expression in cultured neurons, astroglia, and oligodendroglia of rat cerebral cortex. Brain Research. Molecular Brain Research. 45: 138-40. PMID 9105680 DOI: 10.1016/S0169-328X(96)00285-9  1
1996 Davies DL, Bejanian M, Parker ES, Mørland J, Bolger MB, Brinton RD, Alkana RL. Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice. The Journal of Pharmacology and Experimental Therapeutics. 276: 667-75. PMID 8632335  1
1994 Brinton RD, Monreal AW, Fernandez JG. Vasopressin-induced neurotrophism in cultured hippocampal neurons via V1 receptor activation. Journal of Neurobiology. 25: 380-94. PMID 8077964 DOI: 10.1002/neu.480250404  1
1994 Brinton RD, Gonzalez TM, Cheung WS. Vasopressin-induced calcium signaling in cultured hippocampal neurons. Brain Research. 667: 151-9. PMID 7895079 DOI: 10.1016/0006-8993(94)91728-0  1
1993 Brinton RD. 17beta-Estradiol Induction of Filopodial Growth in Cultured Hippocampal Neurons within Minutes of Exposure. Molecular and Cellular Neurosciences. 4: 36-46. PMID 19912906 DOI: 10.1006/mcne.1993.1005  1
1993 Chen C, Díaz Brinton RD, Shors TJ, Thompson RF. Vasopressin induction of long-lasting potentiation of synaptic transmission in the dentate gyrus. Hippocampus. 3: 193-203. PMID 8394770 DOI: 10.1002/hipo.450030211  1
1993 Brinton RD, Brownson EA. Vasopressin-induction of cyclic AMP in cultured hippocampal neurons Developmental Brain Research. 71: 101-105. PMID 8381727 DOI: 10.1016/0165-3806(93)90110-V  1
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