| Year |
Citation |
Score |
| 2023 |
Wang T, Chen S, Mao Z, Shang Y, Brinton RD. Allopregnanolone pleiotropic action in neurons and astrocytes: calcium signaling as a unifying mechanism. Frontiers in Endocrinology. 14: 1286931. PMID 38189047 DOI: 10.3389/fendo.2023.1286931 |
0.309 |
|
| 2020 |
Hay M, Barnes C, Huentelman M, Brinton R, Ryan L. Hypertension and Age-Related Cognitive Impairment: Common Risk Factors and a Role for Precision Aging. Current Hypertension Reports. 22: 80. PMID 32880739 DOI: 10.1007/S11906-020-01090-W |
0.317 |
|
| 2020 |
Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, Brinton RD, Carrero JJ, DeMeo DL, De Vries GJ, Epperson CN, Govindan R, Klein SL, Lonardo A, Maki PM, McCullough LD, Regitz-Zagrosek V, Regensteiner JG, et al. Sex and gender: modifiers of health, disease, and medicine. Lancet (London, England). 396: 565-582. PMID 32828189 DOI: 10.1016/S0140-6736(20)31561-0 |
0.31 |
|
| 2020 |
Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, Beal MF, Bergersen LH, Brinton RD, de la Monte S, Eckert A, Harvey J, Jeggo R, Jhamandas JH, Kann O, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nature Reviews. Drug Discovery. PMID 32709961 DOI: 10.1038/S41573-020-0072-X |
0.371 |
|
| 2020 |
Chen S, Wang T, Yao J, Brinton RD. Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer's Disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 32632771 DOI: 10.1007/S13311-020-00874-X |
0.526 |
|
| 2020 |
Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Annals of the New York Academy of Sciences. PMID 32472577 DOI: 10.1111/Nyas.14371 |
0.378 |
|
| 2020 |
Wang Y, Shang Y, Mishra A, Bacon E, Yin F, Brinton R. Midlife Chronological and Endocrinological Transitions in Brain Metabolism: System Biology Basis for Increased Alzheimer's Risk in Female Brain. Scientific Reports. 10: 8528. PMID 32444841 DOI: 10.1038/S41598-020-65402-5 |
0.408 |
|
| 2020 |
Mi Y, Qi G, Brinton RD, Yin F. Mitochondria Targeted Therapeutics for Alzheimer's Disease: The Good. The Bad. The Potential. Antioxidants & Redox Signaling. PMID 32143551 DOI: 10.1089/Ars.2020.8070 |
0.315 |
|
| 2020 |
Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, et al. Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome. Nature Communications. 11: 1148. PMID 32123170 DOI: 10.1038/S41467-020-14959-W |
0.394 |
|
| 2020 |
Wang Y, Mishra A, Brinton RD. Transitions in metabolic and immune systems from pre-menopause to post-menopause: implications for age-associated neurodegenerative diseases. F1000research. 9. PMID 32047612 DOI: 10.12688/f1000research.21599.1 |
0.388 |
|
| 2020 |
Shang Y, Mishra A, Wang T, Wang Y, Desai M, Chen S, Mao Z, Do L, Bernstein AS, Trouard TP, Brinton RD. Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice. Plos One. 15: e0225392. PMID 31917799 DOI: 10.1371/Journal.Pone.0225392 |
0.366 |
|
| 2020 |
Galea LA, Brinton RD, Cameron HA, Conrad CD, Lupien SJ, Shansky RM, Woolley CS, Gould E. A Tribute to Bruce S. McEwen Trends in Neurosciences. 43: 127-130. DOI: 10.1016/J.Tins.2020.01.006 |
0.76 |
|
| 2019 |
Rahman A, Jackson H, Hristov H, Isaacson RS, Saif N, Shetty T, Etingin O, Henchcliffe C, Brinton RD, Mosconi L. Sex and Gender Driven Modifiers of Alzheimer's: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risks. Frontiers in Aging Neuroscience. 11: 315. PMID 31803046 DOI: 10.3389/fnagi.2019.00315 |
0.397 |
|
| 2019 |
Wang T, Yao J, Chen S, Mao Z, Brinton RD. Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31664643 DOI: 10.1007/S13311-019-00793-6 |
0.582 |
|
| 2019 |
Wang Y, Hernandez G, Mack WJ, Schneider LS, Yin F, Brinton RD. Retrospective analysis of phytoSERM for management of menopause-associated vasomotor symptoms and cognitive decline: a pilot study on pharmacogenomic effects of mitochondrial haplogroup and APOE genotype on therapeutic efficacy. Menopause (New York, N.Y.). PMID 31567873 DOI: 10.1097/Gme.0000000000001418 |
0.343 |
|
| 2019 |
Sriprasert I, Mack WJ, Hodis HN, Allayee H, Brinton RD, Karim R. Effect of ApoE4 Genotype on the Association Between Metabolic Phenotype and Subclinical Atherosclerosis in Postmenopausal Women. The American Journal of Cardiology. PMID 31362877 DOI: 10.1016/J.Amjcard.2019.06.022 |
0.319 |
|
| 2019 |
Desai MK, Brinton RD. Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan. Frontiers in Endocrinology. 10: 265. PMID 31110493 DOI: 10.3389/fendo.2019.00265 |
0.303 |
|
| 2019 |
Schneider LS, Hernandez G, Zhao L, Franke AA, Chen YL, Pawluczyk S, Mack WJ, Brinton RD. Safety and feasibility of estrogen receptor-β targeted phytoSERM formulation for menopausal symptoms: phase 1b/2a randomized clinical trial. Menopause (New York, N.Y.). PMID 30889096 DOI: 10.1097/Gme.0000000000001325 |
0.32 |
|
| 2019 |
Mao Z, Shang Y, Berghout J, Lussier Y, Yin F, Brinton RD. P1-202: EMERGENCE OF AN ALZHEIMER'S DISEASE BIOENERGETIC ENDOPHENOTYPE IN MID-LIFE: PRECLINICAL MODEL Alzheimer's & Dementia. 15: P314-P314. DOI: 10.1016/J.Jalz.2019.06.757 |
0.365 |
|
| 2019 |
Qi G, Mi Y, Chen S, Brinton RD, Yin F. P1-195: APOE ISOFORMS DIFFERENTIATE NEURONAL AND ASTROCYTIC MITOCHONDRIAL BIOENERGETIC CAPACITY AND FUEL DEPENDENCY Alzheimer's & Dementia. 15: P311-P312. DOI: 10.1016/J.Jalz.2019.06.750 |
0.332 |
|
| 2019 |
Yin F, Shang Y, Wang Y, Mishra A, Desai MK, Mao Z, Brinton RD. P1-194: IMPACT OF APOE GENOTYPE ON THE SEX DIFFERENCES IN BIOENERGETICS AND ALZHEIMER'S RISKS IN THE AGING MOUSE BRAIN Alzheimer's & Dementia. 15: P311-P311. DOI: 10.1016/J.Jalz.2019.06.749 |
0.396 |
|
| 2019 |
Wang T, Chen S, Mao Z, Brinton RD. P3-061: ALLOPREGNANOLONE POTENTIATES BIOENERGETIC CAPACITY AND RESTRUCTURES MITOCHONDRIAL RETICULUM IN NEURONS AND ASTROCYTES Alzheimer's & Dementia. 15: P949-P949. DOI: 10.1016/j.jalz.2019.06.3088 |
0.327 |
|
| 2019 |
Chen S, Yao J, Wang T, Brinton RD. P3-060: ALLOPREGNANOLONE REVERSED OVARIECTOMY-INDUCED BIOENERGETIC DEFICITS IN FEMALE TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P948-P949. DOI: 10.1016/J.Jalz.2019.06.3087 |
0.536 |
|
| 2019 |
Wang Y, Solinsky CM, Hernandez GD, Schneider LS, Brinton RD. P3-032: COMBINING SEX, APOE GENOTYPE, AND MITOCHONDRIAL GENETIC VARIANCE AS PREDICTIVE RESPONDER IDENTIFIER TO REGENERATIVE THERAPEUTIC ALLOPREGNANOLONE FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P938-P938. DOI: 10.1016/J.Jalz.2019.06.3058 |
0.385 |
|
| 2019 |
Shang Y, Hernandez GD, Lopez C, Yin F, Schneider LS, Brinton RD. P3-015: ALLOPREGNANOLONE SHOWS SIGNIFICANT EFFECT ON THE LIPID PATHWAYS FROM PLASMA METABOLOMIC ANALYSIS OF ALZHEIMER'S CLINICAL TRIAL Alzheimer's & Dementia. 15: P930-P930. DOI: 10.1016/J.Jalz.2019.06.3041 |
0.318 |
|
| 2018 |
Mosconi L, Rahman A, Diaz I, Wu X, Scheyer O, Hristov HW, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD. Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study. Plos One. 13: e0207885. PMID 30540774 DOI: 10.1371/journal.pone.0207885 |
0.424 |
|
| 2018 |
Mishra A, Brinton RD. Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease. Frontiers in Aging Neuroscience. 10: 312. PMID 30356809 DOI: 10.3389/fnagi.2018.00312 |
0.335 |
|
| 2018 |
Mosconi L, Brinton RD. How would we combat menopause as an Alzheimer's risk factor? Expert Review of Neurotherapeutics. 18: 689-691. PMID 30091648 DOI: 10.1080/14737175.2018.1510320 |
0.327 |
|
| 2018 |
Karim R, Koc M, Rettberg JR, Hodis HN, Henderson VW, St John JA, Allayee H, Brinton RD, Mack WJ. Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease. Menopause (New York, N.Y.). PMID 29975287 DOI: 10.1097/Gme.0000000000001160 |
0.795 |
|
| 2018 |
Chen S, Kumar N, Mao Z, Sitruk-Ware R, Brinton RD. Therapeutic progestin segesterone acetate promotes neurogenesis: implications for sustaining regeneration in female brain. Menopause (New York, N.Y.). PMID 29846284 DOI: 10.1097/GME.0000000000001135 |
0.368 |
|
| 2018 |
Geifman N, Kennedy RE, Schneider LS, Buchan I, Brinton RD. Data-driven identification of endophenotypes of Alzheimer's disease progression: implications for clinical trials and therapeutic interventions. Alzheimer's Research & Therapy. 10: 4. PMID 29370871 DOI: 10.1186/S13195-017-0332-0 |
0.372 |
|
| 2018 |
Brinton RD. Neuroendocrinology: Oestrogen therapy affects brain structure but not function. Nature Reviews. Neurology. 12: 561-2. PMID 27677967 DOI: 10.1038/nrneurol.2016.147 |
0.342 |
|
| 2017 |
Mosconi L, Berti V, Guyara-Quinn C, McHugh P, Petrongolo G, Osorio RS, Connaughty C, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Swerdlow RH, Brinton RD. Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. Plos One. 12: e0185926. PMID 29016679 DOI: 10.1371/Journal.Pone.0185926 |
0.43 |
|
| 2017 |
Hernandez G, Zhao L, Franke AA, Chen YL, Mack WJ, Brinton RD, Schneider LS. Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor β-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause (New York, N.Y.). PMID 28926513 DOI: 10.1097/Gme.0000000000000984 |
0.309 |
|
| 2017 |
Mosconi L, Berti V, Quinn C, McHugh P, Petrongolo G, Varsavsky I, Osorio RS, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD. Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging. Neurology. PMID 28855400 DOI: 10.1212/WNL.0000000000004425 |
0.389 |
|
| 2017 |
Wang JY, Trivedi AM, Carrillo NR, Yang J, Schneider A, Giulivi C, Adams P, Tassone F, Kim K, Rivera SM, Lubarr N, Wu CY, Irwin RW, Brinton RD, Olichney JM, et al. Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28707277 DOI: 10.1007/S13311-017-0555-6 |
0.613 |
|
| 2017 |
Yin F, Yao J, Brinton RD, Cadenas E. Editorial: The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration. Frontiers in Aging Neuroscience. 9: 209. PMID 28701949 DOI: 10.3389/Fnagi.2017.00209 |
0.479 |
|
| 2017 |
Geifman N, Brinton RD, Kennedy RE, Schneider LS, Butte AJ. Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease. Alzheimer's Research & Therapy. 9: 10. PMID 28212683 DOI: 10.1186/S13195-017-0237-Y |
0.363 |
|
| 2016 |
Zissimopoulos JM, Barthold D, Brinton RD, Joyce G. Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease. Jama Neurology. PMID 27942728 DOI: 10.1001/jamaneurol.2016.3783 |
0.323 |
|
| 2016 |
Wang Y, Brinton RD. Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex. Frontiers in Aging Neuroscience. 8: 232. PMID 27757081 DOI: 10.3389/fnagi.2016.00232 |
0.401 |
|
| 2016 |
Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC. Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27692800 DOI: 10.1016/J.Jalz.2016.08.004 |
0.379 |
|
| 2016 |
Zhao L, Mao Z, Woody SK, Brinton RD. Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease. Neurobiology of Aging. 42: 69-79. PMID 27143423 DOI: 10.1016/j.neurobiolaging.2016.02.011 |
0.395 |
|
| 2016 |
Rettberg JR, Dang H, Hodis HN, Henderson VW, St John JA, Mack WJ, Brinton RD. Identifying postmenopausal women at risk for cognitive decline within a healthy cohort using a panel of clinical metabolic indicators: potential for detecting an at-Alzheimer's risk metabolic phenotype. Neurobiology of Aging. 40: 155-63. PMID 26973115 DOI: 10.1016/J.Neurobiolaging.2016.01.011 |
0.798 |
|
| 2016 |
Riedel BC, Thompson PM, Brinton RD. Age, APOE and Sex: Triad of Risk of Alzheimer's Disease. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26969397 DOI: 10.1016/J.Jsbmb.2016.03.012 |
0.789 |
|
| 2016 |
Irwin RW, Solinsky CM, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. P1-072: Comparative Pharmacokinetic Assessment of Allopregnanolone to Develop a Regenerative Therapeutic for Mild Cognitive Impairment and Early Alzheimer’s Disease Alzheimer's & Dementia. 12: P430-P430. DOI: 10.1016/J.Jalz.2016.06.820 |
0.636 |
|
| 2016 |
Brinton RD, Swanson HM, Irwin RW. P4-026: Allopregnanolone Promotes Cholesterol and Amyloid-Beta Clearance Mechanisms: Assessment of a Regenerative Therapeutic for Alzheimer’s Disease Alzheimer's & Dementia. 12: P1024-P1025. DOI: 10.1016/J.Jalz.2016.06.2115 |
0.626 |
|
| 2016 |
Klosinski L, Yao J, Fonteh A, Harrington M, Christensen T, Trushina E, Brinton RD. P2-117: Perimenopause in APOE4 Brain: Accelerated Myelin Catabolism for Fuel Alzheimer's & Dementia. 12: P656-P657. DOI: 10.1016/J.Jalz.2016.06.1487 |
0.461 |
|
| 2015 |
Klosinski LP, Yao J, Yin F, Fonteh AN, Harrington MG, Christensen TA, Trushina E, Brinton RD. White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease. Ebiomedicine. 2: 1888-904. PMID 26844268 DOI: 10.1016/J.Ebiom.2015.11.002 |
0.566 |
|
| 2015 |
Irwin RW, Solinsky CM, Loya CM, Salituro FG, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease. Plos One. 10: e0128313. PMID 26039057 DOI: 10.1371/Journal.Pone.0128313 |
0.649 |
|
| 2015 |
Brinton RD, Yao J, Yin F, Mack WJ, Cadenas E. Perimenopause as a neurological transition state. Nature Reviews. Endocrinology. 11: 393-405. PMID 26007613 DOI: 10.1038/Nrendo.2015.82 |
0.512 |
|
| 2015 |
Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiology of Aging. 36: 2282-95. PMID 25921624 DOI: 10.1016/J.Neurobiolaging.2015.03.013 |
0.532 |
|
| 2015 |
Caldwell CC, Yao J, Brinton RD. Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 66-80. PMID 25534394 DOI: 10.1007/S13311-014-0324-8 |
0.534 |
|
| 2015 |
Karim R, Stanczyk FZ, Brinton RD, Rettberg J, Hodis HN, Mack WJ. Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women. The Journal of Clinical Endocrinology and Metabolism. 100: 508-15. PMID 25405497 DOI: 10.1210/Jc.2014-1839 |
0.775 |
|
| 2015 |
Irwin RW, Kim K, Green CE, Solinsky CM, Bauer G, Rogawski MA, Rodgers KE, Brinton RD. P1-303: Allopregnanolone chronic exposure using regenerative treatment regimen: Preclinical ind enabling toxicology indicating safety Alzheimer's & Dementia. 11: P472-P473. DOI: 10.1016/J.Jalz.2015.06.518 |
0.587 |
|
| 2015 |
Klosinski LP, Yao J, Yin F, Fonteh AN, Harrington MG, Christensen TA, Trushina E, Brinton RD. White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease Ebiomedicine. DOI: 10.1016/j.ebiom.2015.11.002 |
0.454 |
|
| 2014 |
Irwin RW, Solinsky CM, Brinton RD. Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders. Frontiers in Cellular Neuroscience. 8: 203. PMID 25126056 DOI: 10.3389/Fncel.2014.00203 |
0.685 |
|
| 2014 |
Irwin RW, Brinton RD. Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise. Progress in Neurobiology. 113: 40-55. PMID 24044981 DOI: 10.1016/J.Pneurobio.2013.08.004 |
0.68 |
|
| 2014 |
Rettberg JR, Yao J, Brinton RD. Estrogen: a master regulator of bioenergetic systems in the brain and body. Frontiers in Neuroendocrinology. 35: 8-30. PMID 23994581 DOI: 10.1016/J.Yfrne.2013.08.001 |
0.81 |
|
| 2014 |
Brinton RD, Zhao L, Yin F, Yao J, Cadenas E. P1-101: SEX DIFFERENCES IN BIOENERGETIC AGING OF THE BRAIN AND RISK OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P339-P339. DOI: 10.1016/J.Jalz.2014.05.338 |
0.549 |
|
| 2013 |
Ding F, Yao J, Rettberg JR, Chen S, Brinton RD. Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention. Plos One. 8: e79977. PMID 24244584 DOI: 10.1371/Journal.Pone.0079977 |
0.797 |
|
| 2013 |
Fuente-Martin E, Garcia-Caceres C, Morselli E, Clegg DJ, Chowen JA, Finan B, Brinton RD, Tschöp MH. Estrogen, astrocytes and the neuroendocrine control of metabolism. Reviews in Endocrine & Metabolic Disorders. 14: 331-8. PMID 24009071 DOI: 10.1007/S11154-013-9263-7 |
0.352 |
|
| 2013 |
Zhao L, Mao Z, Chen S, Schneider LS, Brinton RD. Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 37: 403-19. PMID 23948892 DOI: 10.3233/Jad-122341 |
0.421 |
|
| 2013 |
Sancheti H, Akopian G, Yin F, Brinton RD, Walsh JP, Cadenas E. Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. Plos One. 8: e69830. PMID 23875003 DOI: 10.1371/Journal.Pone.0069830 |
0.36 |
|
| 2013 |
Jiang T, Yin F, Yao J, Brinton RD, Cadenas E. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway. Aging Cell. 12: 1021-31. PMID 23815272 DOI: 10.1111/Acel.12127 |
0.507 |
|
| 2013 |
Singh M, Simpkins JW, Simpkins JW, Bimonte-Nelson HA, Bimonte-Nelson HA, Brinton RD, Brinton RD. Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease. Brain Research. 1514: 1-2. PMID 23726132 DOI: 10.1016/J.Brainres.2013.04.044 |
0.406 |
|
| 2013 |
Ding F, Yao J, Zhao L, Mao Z, Chen S, Brinton RD. Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's. Plos One. 8: e59825. PMID 23555795 DOI: 10.1371/Journal.Pone.0059825 |
0.645 |
|
| 2013 |
Brinton RD. Neurosteroids as regenerative agents in the brain: therapeutic implications. Nature Reviews. Endocrinology. 9: 241-50. PMID 23438839 DOI: 10.1038/nrendo.2013.31 |
0.391 |
|
| 2013 |
Yao J, Zhao L, Mao Z, Chen S, Wong KC, To J, Brinton RD. Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments. Brain Research. 1514: 128-41. PMID 23428542 DOI: 10.1016/J.Brainres.2013.02.021 |
0.564 |
|
| 2013 |
Mao Z, Brinton R, Schneider L, Zhao L. P2-015: Estrogen receptor-β regulation of insulin signaling and energy metabolism in APOE- ε2, ε3, ε4 brains Alzheimer's & Dementia. 9: P350-P350. DOI: 10.1016/J.Jalz.2013.05.657 |
0.337 |
|
| 2013 |
Zhao L, Yao J, Ding F, Chen S, Klosinski L, Rettberg J, Brinton R. P2-011: A bioenergetic trajectory of female brain aging and Alzheimer's disease 1: Implications for risk prevention and treatment Alzheimer's & Dementia. 9: P349-P349. DOI: 10.1016/J.Jalz.2013.05.653 |
0.791 |
|
| 2013 |
Rettberg J, Mack W, Hodis H, Dang H, Zhao L, Schneider L, Stanczyk F, Brinton R. P2-010: A bioenergetic trajectory of female brain aging and Alzheimer's disease 3: Development of metabolic and physiological biomarker profiles for early detection of women at risk for Alzheimer's disease Alzheimer's & Dementia. 9: P348-P349. DOI: 10.1016/J.Jalz.2013.05.652 |
0.82 |
|
| 2013 |
Klosinski L, Yao J, Chen S, Mao Z, Zhao L, Brinton R. P2-008: A bioenergetic trajectory of female brain aging and Alzheimer's disease 2: Mechanistic link between mitochondrial dysfunction and white matter degeneration in the normal mammalian aging female brain Alzheimer's & Dementia. 9: P348-P348. DOI: 10.1016/J.Jalz.2013.05.650 |
0.549 |
|
| 2013 |
Irwin R, Chen S, To J, Zhu M, Yao J, Rodgers K, Bolger M, Brinton R. P4-016: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 2: Bridging subcutaneous to intravenous formulations for clinical trials Alzheimer's & Dementia. 9: P710-P711. DOI: 10.1016/J.Jalz.2013.05.1404 |
0.695 |
|
| 2013 |
Chen S, Yao J, Wong K, Brinton R. P4-014: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 4: Impact on neuronal versus gliosis phenotypic differentiation Alzheimer's & Dementia. 9: P710-P710. DOI: 10.1016/J.Jalz.2013.05.1402 |
0.532 |
|
| 2013 |
Yao J, Chen S, Wong K, Irwin R, Brinton R. P4-013: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 3: Evidence for potentiation of brain mitochondrial function Alzheimer's & Dementia. 9: P709-P710. DOI: 10.1016/J.Jalz.2013.05.1401 |
0.737 |
|
| 2013 |
Brinton R, Irwin R, Mack W, Rodgers K, Bauer G, Rogawski M, Schneider L. P4-012: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 1: From discovery to phase I multiple-ascending-dose clinical trial Alzheimer's & Dementia. 9: P709-P709. DOI: 10.1016/J.Jalz.2013.05.1400 |
0.636 |
|
| 2012 |
Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ. 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology. 153: 5467-79. PMID 22962256 DOI: 10.1210/En.2012-1464 |
0.404 |
|
| 2012 |
Yao J, Brinton RD. Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease. Advances in Pharmacology (San Diego, Calif.). 64: 327-71. PMID 22840752 DOI: 10.1016/B978-0-12-394816-8.00010-6 |
0.559 |
|
| 2012 |
Reiman EM, Brinton RD, Katz R, Petersen RC, Negash S, Mungas D, Aisen PS. Considerations in the design of clinical trials for cognitive aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 766-72. PMID 22573913 DOI: 10.1093/Gerona/Gls124 |
0.308 |
|
| 2012 |
Wang JM, Hou X, Adeosun S, Hill R, Henry S, Paul I, Irwin RW, Ou XM, Bigler S, Stockmeier C, Brinton RD, Gomez-Sanchez E. A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats. Plos One. 7: e33493. PMID 22428062 DOI: 10.1371/Journal.Pone.0033493 |
0.632 |
|
| 2012 |
Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. Plos One. 7: e31267. PMID 22393359 DOI: 10.1371/Journal.Pone.0031267 |
0.36 |
|
| 2012 |
Sun C, Ou X, Farley JM, Stockmeier C, Bigler S, Brinton RD, Wang JM. Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease. Current Alzheimer Research. 9: 473-80. PMID 22272610 DOI: 10.2174/156720512800492567 |
0.317 |
|
| 2012 |
Bali N, Arimoto JM, Iwata N, Lin SW, Zhao L, Brinton RD, Morgan TE, Finch CE. Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis. Endocrinology. 153: 759-69. PMID 22147012 DOI: 10.1210/En.2011-1699 |
0.334 |
|
| 2012 |
Irwin RW, Yao J, To J, Hamilton RT, Cadenas E, Brinton RD. Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function. Journal of Neuroendocrinology. 24: 236-48. PMID 22070562 DOI: 10.1111/J.1365-2826.2011.02251.X |
0.712 |
|
| 2012 |
Singh C, Liu L, Wang JM, Irwin RW, Yao J, Chen S, Henry S, Thompson RF, Brinton RD. Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice. Neurobiology of Aging. 33: 1493-506. PMID 21803451 DOI: 10.1016/J.Neurobiolaging.2011.06.008 |
0.792 |
|
| 2012 |
Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, Brinton RD. Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid. Neurobiology of Aging. 33: 1507-21. PMID 21514693 DOI: 10.1016/J.Neurobiolaging.2011.03.001 |
0.728 |
|
| 2012 |
Mao Z, Zhao L, Yao J, Ding F, Cadenas E, Brinton R. P2-129: Effects of age and reproductive status on gene expression in the female hippocampus Alzheimer's & Dementia. 8: P305-P305. DOI: 10.1016/J.Jalz.2012.05.834 |
0.587 |
|
| 2012 |
Rettberg J, Mack W, Hodis H, Zhao L, Stanczyk F, Brinton R. P2-053: Biomarkers of metabolic function for early detection of women at risk for Alzheimer's disease Alzheimer's & Dementia. 8: P281-P282. DOI: 10.1016/J.Jalz.2012.05.757 |
0.802 |
|
| 2012 |
Ding F, Luo J, Yao J, Mao Z, Chen S, Chen K, Reiman E, Brinton R. P1-135: Ovarian hormone loss induced decline in glucose availability and shift to alternative substrates in brain Alzheimer's & Dementia. 8: P153-P153. DOI: 10.1016/J.Jalz.2012.05.412 |
0.62 |
|
| 2012 |
Yao J, Ding F, Chen S, Mao Z, Cadenas E, Brinton R. P4-226: Shift in brain mitochondrial bioenergetics in aging and Alzheimer's: Implications for disease prevention and treatment Alzheimer's & Dementia. 8: P714-P714. DOI: 10.1016/J.Jalz.2012.05.1931 |
0.671 |
|
| 2012 |
Adeosun S, Hou X, Zheng B, Paul I, Irwin R, Brinton R, Wang J. Motor deficits in mouse models of Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1813 |
0.629 |
|
| 2012 |
Zhao L, Mao Z, Brinton R. P4-026: Activation of estrogen receptor beta promotes IRS/PI3K/AKT/GSK3B-mediated insulin signaling in the female brain: Implications for anti-aging and Alzheimer's prevention Alzheimer's & Dementia. 8: P645-P645. DOI: 10.1016/j.jalz.2012.05.1727 |
0.372 |
|
| 2012 |
Irwin R, Chen S, Zhu M, Hernandez E, Rodgers K, Wang J, Bolger M, Brinton R. P2-393: Allopregnanolone as a regenerative therapeutic for Alzheimer's: Formulation development for clinical trials Alzheimer's & Dementia. 8: P400-P400. DOI: 10.1016/J.Jalz.2012.05.1103 |
0.635 |
|
| 2012 |
Zhu M, Irwin R, Chen S, Brinton R. P2-386: Allopregnanolone as a regenerative drug candidate in a female mouse model of Alzheimer's disease Alzheimer's & Dementia. 8: P398-P398. DOI: 10.1016/J.Jalz.2012.05.1096 |
0.648 |
|
| 2011 |
Irwin RW, Wang JM, Chen S, Brinton RD. Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. Frontiers in Endocrinology. 2: 117. PMID 22654847 DOI: 10.3389/Fendo.2011.00117 |
0.67 |
|
| 2011 |
Yao J, Rettberg JR, Klosinski LP, Cadenas E, Brinton RD. Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Molecular Aspects of Medicine. 32: 247-57. PMID 22024249 DOI: 10.1016/J.Mam.2011.10.005 |
0.813 |
|
| 2011 |
Chen S, Wang JM, Irwin RW, Yao J, Liu L, Brinton RD. Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. Plos One. 6: e24293. PMID 21918687 DOI: 10.1371/Journal.Pone.0024293 |
0.781 |
|
| 2011 |
Yao J, Brinton RD. Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment. Current Pharmaceutical Design. 17: 3474-9. PMID 21902662 DOI: 10.2174/138161211798072517 |
0.58 |
|
| 2011 |
Yao J, Chen S, Mao Z, Cadenas E, Brinton RD. 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. Plos One. 6: e21788. PMID 21747957 DOI: 10.1371/Journal.Pone.0021788 |
0.575 |
|
| 2011 |
Zhao L, Mao Z, Schneider LS, Brinton RD. Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause. Menopause (New York, N.Y.). 18: 1131-42. PMID 21738079 DOI: 10.1097/Gme.0B013E3182175B66 |
0.34 |
|
| 2011 |
Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Research. 1379: 11-22. PMID 21241683 DOI: 10.1016/J.Brainres.2011.01.029 |
0.795 |
|
| 2011 |
Wu TW, Chen S, Brinton RD. Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons. Brain Research. 1379: 34-43. PMID 21241678 DOI: 10.1016/J.Brainres.2011.01.034 |
0.5 |
|
| 2011 |
Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Research. 1379: 23-33. PMID 21238431 DOI: 10.1016/J.Brainres.2011.01.012 |
0.785 |
|
| 2011 |
Irwin RW, Yao J, Ahmed SS, Hamilton RT, Cadenas E, Brinton RD. Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology. 152: 556-67. PMID 21159850 DOI: 10.1210/En.2010-1061 |
0.719 |
|
| 2011 |
Yao J, Chen S, Cadenas E, Brinton RD. Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone. Brain Research. 1379: 2-10. PMID 21134358 DOI: 10.1016/J.Brainres.2010.11.090 |
0.521 |
|
| 2011 |
Zhao L, Yao J, Mao Z, Chen S, Wang Y, Brinton RD. 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiology of Aging. 32: 1949-63. PMID 20053478 DOI: 10.1016/J.Neurobiolaging.2009.12.010 |
0.553 |
|
| 2011 |
Zhao L, Mao Z, Schneider L, Brinton R. P3-480: Phyto-beta-SERM formulation for menopause and Alzheimer's disease: From bench to bedside Alzheimer's & Dementia. 7: S669-S669. DOI: 10.1016/J.Jalz.2011.05.1925 |
0.374 |
|
| 2011 |
Yao J, Chen S, Irwin R, Mao Z, Cadenas E, Brinton R. P3-476: Preclinical efficacy of 2-Deoxyglucose to sustain mitochondrial metabolic function and delay progression of Alzheimer's pathology Alzheimer's & Dementia. 7: S667-S668. DOI: 10.1016/J.Jalz.2011.05.1921 |
0.722 |
|
| 2011 |
Wang J, Adeosun S, Jiao Y, Zheng B, Henry S, Hou X, Sun C, Pani A, Kyle P, Farley J, Paul I, Bigler S, Stockmeier C, Brinton R, Smeyne R. P3-473: The impact of a neurogenic agent, allopregnanolone, in rodent models of Alzheimer's and Parkinson's disease Alzheimer's & Dementia. 7: S667-S667. DOI: 10.1016/J.Jalz.2011.05.1918 |
0.364 |
|
| 2011 |
She H, Chen S, Wang J, Bortolato M, Singh C, Foy M, Brinton R. P2-517: Preclinical development of allopregnanolone to restore cognitive function in a mouse model of Alzheimer's disease: transdermal and intranasal drug delivery Alzheimer's & Dementia. 7: S477-S478. DOI: 10.1016/J.Jalz.2011.05.1388 |
0.36 |
|
| 2011 |
Liu L, Brinton RD. Gonadal Hormones, Neurosteroids, and Clinical Progestins as Neurogenic Regenerative Agents: Therapeutic Implications Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis. 281-303. DOI: 10.1002/9783527633968.ch17 |
0.539 |
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| 2010 |
Liu L, Zhao L, She H, Chen S, Wang JM, Wong C, McClure K, Sitruk-Ware R, Brinton RD. Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo. Endocrinology. 151: 5782-94. PMID 20943809 DOI: 10.1210/En.2010-0005 |
0.635 |
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| 2010 |
Henderson VW, Brinton RD. Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy. Progress in Brain Research. 182: 77-96. PMID 20541661 DOI: 10.1016/S0079-6123(10)82003-5 |
0.445 |
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| 2010 |
Yao J, Hamilton RT, Cadenas E, Brinton RD. Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Biochimica Et Biophysica Acta. 1800: 1121-6. PMID 20538040 DOI: 10.1016/J.Bbagen.2010.06.002 |
0.562 |
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| 2010 |
Wang JM, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 6498-503. PMID 20231471 DOI: 10.1073/Pnas.1001422107 |
0.769 |
|
| 2010 |
Wang M, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 14, (6498-6503) DOI: 10.1073/pnas. 1001422107) Proceedings of the National Academy of Sciences of the United States of America. 107: 11145. DOI: 10.1073/pnas.1006236107 |
0.67 |
|
| 2010 |
Irwin RW, Singh C, Liu L, Wang J, Yao J, Chen S, Henry S, Thompson RF, Brinton RD. P3-369: Allopregnanolone promotes neurogenesis, restores cognitive function and reduces Alzheimer's pathology in adult triple transgenic Alzheimer's mice: Preclinical development and formulation Alzheimer's & Dementia. 6: S560-S560. DOI: 10.1016/J.Jalz.2010.05.1911 |
0.78 |
|
| 2010 |
Yao J, Irwin R, Chen S, Brinton RD. P3-365: Deficits in mitochondrial bioenergetics and mitochondrial beta-amyloid deposition in brain are associated with reproductive senescence and loss of ovarian hormones: Prevention by estradiol Alzheimer's & Dementia. 6: S559-S559. DOI: 10.1016/J.Jalz.2010.05.1907 |
0.707 |
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| 2010 |
Brinton RD, Gore AC, Schmidt PJ, Morrison JH. Reproductive aging of females: Neural systems Hormones, Brain and Behavior Online. 2199-2224. DOI: 10.1016/B978-008088783-8.00068-1 |
0.327 |
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| 2009 |
Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 14670-5. PMID 19667196 DOI: 10.1073/Pnas.0903563106 |
0.787 |
|
| 2009 |
Liu L, Wang J, Zhao L, Nilsen J, McClure K, Wong K, Brinton RD. Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2. Endocrinology. 150: 3186-96. PMID 19359388 DOI: 10.1210/En.2008-1447 |
0.714 |
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| 2009 |
Brinton RD. Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends in Pharmacological Sciences. 30: 212-22. PMID 19299024 DOI: 10.1016/j.tips.2008.12.006 |
0.378 |
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| 2009 |
Asthana S, Brinton RD, Henderson VW, McEwen BS, Morrison JH, Schmidt PJ. Frontiers proposal. National Institute on Aging "bench to bedside: estrogen as a case study". Age (Dordrecht, Netherlands). 31: 199-210. PMID 19277902 DOI: 10.1007/s11357-009-9087-2 |
0.503 |
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| 2009 |
Zhao L, Mao Z, Brinton RD. A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. Endocrinology. 150: 770-83. PMID 18818291 DOI: 10.1210/en.2008-0715 |
0.359 |
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| 2008 |
Brinton RD. The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications. Trends in Neurosciences. 31: 529-37. PMID 18774188 DOI: 10.1016/j.tins.2008.07.003 |
0.403 |
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| 2008 |
Brinton RD. Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease. Advanced Drug Delivery Reviews. 60: 1504-11. PMID 18647624 DOI: 10.1016/j.addr.2008.06.003 |
0.469 |
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| 2008 |
Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J. Progesterone receptors: form and function in brain. Frontiers in Neuroendocrinology. 29: 313-39. PMID 18374402 DOI: 10.1016/J.Yfrne.2008.02.001 |
0.634 |
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| 2008 |
Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology. 149: 3167-75. PMID 18292191 DOI: 10.1210/En.2007-1227 |
0.787 |
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| 2008 |
Wang JM, Liu L, Brinton RD. Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway. Endocrinology. 149: 208-18. PMID 17962344 DOI: 10.1210/En.2007-1155 |
0.62 |
|
| 2008 |
Wang JM, Liu L, Irwin RW, Chen S, Brinton RD. Regenerative potential of allopregnanolone. Brain Research Reviews. 57: 398-409. PMID 17931704 DOI: 10.1016/J.Brainresrev.2007.08.010 |
0.773 |
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| 2007 |
Wang JM, Irwin RW, Liu L, Chen S, Brinton RD. Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent. Current Alzheimer Research. 4: 510-7. PMID 18220513 DOI: 10.2174/156720507783018262 |
0.776 |
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| 2007 |
Nilsen J, Irwin RW, Gallaher TK, Brinton RD. Estradiol in vivo regulation of brain mitochondrial proteome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14069-77. PMID 18094246 DOI: 10.1523/Jneurosci.4391-07.2007 |
0.754 |
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| 2007 |
Zhao L, Brinton RD. WHI and WHIMS follow-up and human studies of soy isoflavones on cognition. Expert Review of Neurotherapeutics. 7: 1549-64. PMID 17997703 DOI: 10.1586/14737175.7.11.1549 |
0.366 |
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| 2007 |
Zhao L, Brinton RD. Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons. Brain Research. 1172: 48-59. PMID 17803971 DOI: 10.1016/j.brainres.2007.06.092 |
0.342 |
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| 2007 |
Zhao L, Jin C, Mao Z, Gopinathan MB, Rehder K, Brinton RD. Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons. Journal of Medicinal Chemistry. 50: 4471-81. PMID 17696335 DOI: 10.1021/Jm070546X |
0.364 |
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| 2007 |
Zhao L, Brinton RD. P-078: Preclinical investigation of combined use of select ERβ-selective phytoserms as a potential estrogen alternative strategy for prevention of Alzheimer's disease in women Alzheimer's & Dementia. 3: S123-S124. DOI: 10.1016/j.jalz.2007.04.331 |
0.371 |
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| 2007 |
Wang JM, Liu L, Irwin RW, Chen S, Chung EJ, Seligman E, Brinton RD. P-076: Estrogen receptor-selective ligands regulate ApoE expression and neurogenesis in 3xTgAD mouse hippocampus Alzheimer's & Dementia. 3: S123-S123. DOI: 10.1016/J.Jalz.2007.04.329 |
0.73 |
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| 2007 |
Nilsen J, Irwin RW, Yao J, Brinton RD. P-073: Prevention of Alzheimer's pathology: Estrogen targeting of mitochondrial function Alzheimer's & Dementia. 3: S122-S122. DOI: 10.1016/J.Jalz.2007.04.326 |
0.783 |
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| 2007 |
Wang JM, Singh C, Irwin RW, Liu L, Chen S, Thompson RF, Brinton RD. O2-04-07: Allopregnanolone reverses the neurogenic and cognitive deficits of triple transgenic Alzheimer mice Alzheimer's & Dementia. 3: S194-S194. DOI: 10.1016/J.Jalz.2007.04.302 |
0.721 |
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| 2006 |
Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. Bmc Neuroscience. 7: 74. PMID 17083736 DOI: 10.1186/1471-2202-7-74 |
0.744 |
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| 2006 |
Wang JM, Irwin RW, Brinton RD. Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 16983-8. PMID 17077142 DOI: 10.1073/Pnas.0608128103 |
0.663 |
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| 2006 |
Morrison JH, Brinton RD, Schmidt PJ, Gore AC. Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10332-48. PMID 17035515 DOI: 10.1523/Jneurosci.3369-06.2006 |
0.319 |
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| 2006 |
Zhao L, O'Neill K, Brinton RD. Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. The Journal of Pharmacology and Experimental Therapeutics. 319: 1124-32. PMID 16951259 DOI: 10.1124/jpet.106.109504 |
0.372 |
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| 2006 |
Chen S, Nilsen J, Brinton RD. Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications. Endocrinology. 147: 5303-13. PMID 16916950 DOI: 10.1210/en.2006-0495 |
0.602 |
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| 2006 |
Nilsen J, Morales A, Brinton RD. Medroxyprogesterone acetate exacerbates glutamate excitotoxicity. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology. 22: 355-61. PMID 16864144 DOI: 10.1080/09513590600863337 |
0.594 |
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| 2006 |
Brinton RD, Wang JM. Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent. Current Alzheimer Research. 3: 185-90. PMID 16842093 DOI: 10.2174/156720506777632817 |
0.378 |
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| 2006 |
Kim MT, Soussou W, Gholmieh G, Ahuja A, Tanguay A, Berger TW, Brinton RD. 17beta-Estradiol potentiates field excitatory postsynaptic potentials within each subfield of the hippocampus with greatest potentiation of the associational/commissural afferents of CA3. Neuroscience. 141: 391-406. PMID 16725270 DOI: 10.1016/J.Neuroscience.2006.03.075 |
0.475 |
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| 2006 |
Zhao L, Brinton RD. Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease. Bmc Neuroscience. 7: 24. PMID 16533397 DOI: 10.1186/1471-2202-7-24 |
0.387 |
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| 2006 |
Brinton RD, Wang JM. Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease. Current Alzheimer Research. 3: 11-7. PMID 16472197 DOI: 10.2174/156720506775697160 |
0.389 |
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| 2006 |
Mishra A, Yin F, Mao Z, Shang Y, Do L, Trouard TP, Brinton RD. P2-204: SEX DIFFERENCES IN METABOLIC AND INFLAMMATORY AGING OF THE BRAIN IN HUMANIZED APOE-ε4 KNOCK-IN RATS Alzheimer's & Dementia. 14: P746-P747. DOI: 10.1016/J.Jalz.2018.06.892 |
0.345 |
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| 2006 |
Chen S, Kumar N, Mao Z, Wang T, Sitruk-Ware R, Brinton RD. P2-165: THERAPEUTIC PROGESTIN NESTORONE PROMOTES NEUROGENESIS: IMPLICATIONS FOR SUSTAINING REGENERATION IN FEMALE BRAIN Alzheimer's & Dementia. 14: P732-P732. DOI: 10.1016/j.jalz.2018.06.852 |
0.342 |
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| 2006 |
Desai MK, Irwin RW, Prajapati M, Pathak KV, McGilvrey M, Pirrotte P, Brinton RD. P2-129: ALLOPREGNANOLONE RESTORES COGNITIVE FUNCTION IN APOE4+ FEMALES AND MALES AND PROMOTES METABOLISM OF FUELS REQUIRED FOR ATP GENERATION Alzheimer's & Dementia. 14: P717-P718. DOI: 10.1016/J.Jalz.2018.06.815 |
0.631 |
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| 2006 |
Brinton RD, Yin F, Mosconi L. F2-01-01: TRANSITIONS OF THE AGING FEMALE BRAIN: WINDOW INTO UNDERLYING MECHANISMS OF LATE ONSET ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P601-P602. DOI: 10.1016/J.Jalz.2018.06.2611 |
0.369 |
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| 2006 |
Mao Z, Yin F, Yao J, Brinton RD. P3-147: RESPONSE TO HORMONAL INTERVENTION IN AGING FEMALE BRAIN IS ENDOCRINE STATUS DEPENDENT: IMPLICATIONS FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1124-P1124. DOI: 10.1016/J.Jalz.2018.06.1504 |
0.547 |
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| 2006 |
Yin F, Shang Y, Berghout J, Lussier Y, Brinton RD. P3-133: A BIOENERGETIC-INFLAMMATORY TRANSITION STATE CHARACTERIZES PERIMENOPAUSAL AGING BRAIN AND INDICATES ALZHEIMER'S VULNERABILITY Alzheimer's & Dementia. 14: P1118-P1119. DOI: 10.1016/J.Jalz.2018.06.1490 |
0.365 |
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| 2006 |
Hernandez GD, Lopez C, Desai MK, Kono N, Irwin RW, Rodgers KE, Mack WJ, Rogawski MA, Schneider LS, Brinton RD. P1-053: PHARMACOKINETICS AND SAFETY PROFILE OF INTRAVENOUS ADMINISTRATION OF ALLOPREGNANOLONE IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P288-P288. DOI: 10.1016/J.Jalz.2018.06.055 |
0.647 |
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| 2006 |
Wang Y, Solinsky CM, Hernandez GD, Schneider LS, Brinton RD. P1-018: MITOCHONDRIAL HAPLOGROUP IN COMBINATION WITH APOE GENOTYPE AS POTENTIAL PREDICTIVE BIOMARKER TO IDENTIFY RESPONDERS TO REGENERATIVE THERAPEUTIC ALLOPREGNANOLONE FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P271-P272. DOI: 10.1016/J.Jalz.2018.06.019 |
0.396 |
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| 2006 |
Zhao L, Brinton RD. P4-414: Impact of ERβ-selective phytoserm formulations on neuronal survival and morphogenesis: Promise as an estrogen alternative replacement therapy for prevention of Alzheimer's disease and related neurological disorders Alzheimer's & Dementia. 2: S639-S640. DOI: 10.1016/j.jalz.2006.05.2156 |
0.361 |
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| 2006 |
Nilsen J, Irwin RW, Brinton RD. P4-390: Brain mitochondria as therapeutic target for the prevention of Alzheimers pathology Alzheimer's & Dementia. 2: S632-S633. DOI: 10.1016/J.Jalz.2006.05.2131 |
0.756 |
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| 2006 |
Brinton RD, Wang JM, Irwin R, Liu L, Chen S, Wu T. P4-350: Promotion of neurogenesis in the triple transgenic Alzheimer's mouse dentate gyrus and subventricular zone by the neurosteroid allopregnanolone Alzheimer's & Dementia. 2: S620-S620. DOI: 10.1016/J.Jalz.2006.05.2091 |
0.782 |
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| 2005 |
Nilsen J, Deng J, Brinton RD. Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involved. Drug News & Perspectives. 18: 545-53. PMID 16421627 DOI: 10.1358/dnp.2005.18.9.948450 |
0.622 |
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| 2005 |
Wu TW, Wang JM, Chen S, Brinton RD. 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Neuroscience. 135: 59-72. PMID 16084662 DOI: 10.1016/j.neuroscience.2004.12.027 |
0.512 |
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| 2005 |
Brinton RD. Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action. Annals of the New York Academy of Sciences. 1052: 57-74. PMID 16024751 DOI: 10.1196/annals.1347.005 |
0.401 |
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| 2005 |
Wang JM, Johnston PB, Ball BG, Brinton RD. The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4706-18. PMID 15888646 DOI: 10.1523/JNEUROSCI.4520-04.2005 |
0.307 |
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| 2005 |
Lowell J, Vazquez MC, Swerdlow R, Khan S, Fagan T, David D, Nilsen J, Smigrodzki R, Reddy PH, Leski M, Brinton RD, Pugh M. Alzheimer Research Forum Live Discussion: A "Mitochondrial Cascade Hypothesis" for sporadic Alzheimer's disease Journal of Alzheimer's Disease. 8: 311-315. DOI: 10.3233/Jad-2005-8310 |
0.64 |
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| 2005 |
Ming Wang J, Brinton RD. [P-189]: Differential regulation of apolipoprotein E expression by estrogen receptor A and B isoform-selective ligands: Estrogen receptor selective hormone therapy Alzheimer's & Dementia. 1: S68-S68. DOI: 10.1016/j.jalz.2005.06.248 |
0.303 |
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| 2005 |
Zhao L, Brinton RD. Estrogen receptor β as a therapeutic target for promoting neurogenesis and preventing neurodegeneration Drug Development Research. 66: 103-117. DOI: 10.1002/ddr.20049 |
0.374 |
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| 2004 |
Brinton RD. Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERM. Journal of Alzheimer's Disease : Jad. 6: S27-35. PMID 15665410 DOI: 10.3233/Jad-2004-6S607 |
0.428 |
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| 2004 |
Nilsen J, Brinton RD. Mitochondria as therapeutic targets of estrogen action in the central nervous system. Current Drug Targets. Cns and Neurological Disorders. 3: 297-313. PMID 15379606 DOI: 10.2174/1568007043337193 |
0.652 |
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| 2004 |
Brinton RD. Impact of estrogen therapy on Alzheimer's disease: a fork in the road? Cns Drugs. 18: 405-22. PMID 15139797 DOI: 10.2165/00023210-200418070-00001 |
0.406 |
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| 2004 |
Zhao L, Wu TW, Brinton RD. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Brain Research. 1010: 22-34. PMID 15126114 DOI: 10.1016/J.Brainres.2004.02.066 |
0.544 |
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| 2004 |
Zhao L, Brinton RD. Suppression of proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha in astrocytes by a V1 vasopressin receptor agonist: a cAMP response element-binding protein-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2226-35. PMID 14999073 DOI: 10.1523/Jneurosci.4922-03.2004 |
0.477 |
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| 2004 |
O'Neill K, Chen S, Brinton RD. Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease. Experimental Neurology. 185: 63-80. PMID 14697319 DOI: 10.1016/j.expneurol.2003.09.005 |
0.324 |
|
| 2004 |
Brinton RD, Nilsen J. P1-426 Divergent impact of progestins in vitro predicts Alzheimer's disease risk in women using hormone therapy Neurobiology of Aging. 25: S220. DOI: 10.1016/S0197-4580(04)80738-3 |
0.633 |
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| 2004 |
Nilsen J, Brinton RD. P1-355 Estrogen regulates mitochondrial function: mechanisms for protection against degenerative insults Neurobiology of Aging. 25: S199. DOI: 10.1016/S0197-4580(04)80667-5 |
0.618 |
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| 2003 |
Alt J, Angst J, Backstrom T, Baulieu EE, Berga S, Birkhaeuser MH, Bixler EO, Brincat M, Brinton RD, Bryant H, Canonico P, Cassano GB, Da Silva I, Dell'Osso L, Drago F, et al. Hormone replacement therapy in climacteric and aging brain Gynecological Endocrinology. 17: 363-378. PMID 14710584 DOI: 10.1080/09513590312331290258 |
0.412 |
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| 2003 |
Brinton RD, Nilsen J. Effects of estrogen plus progestin on risk of dementia. Jama. 290: 1706; author reply 1. PMID 14519699 DOI: 10.1001/Jama.290.13.1706-A |
0.587 |
|
| 2003 |
Nilsen J, Brinton RD. Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 100: 10506-11. PMID 12925744 DOI: 10.1073/pnas.1334098100 |
0.617 |
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| 2003 |
Zhao L, Chen S, Brinton RD. An estrogen replacement therapy containing nine synthetic plant-based conjugated estrogens promotes neuronal survival. Experimental Biology and Medicine (Maywood, N.J.). 228: 823-35. PMID 12876302 DOI: 10.1177/15353702-0322807-08 |
0.554 |
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| 2003 |
Zhao L, Brinton RD. Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4228-39. PMID 12764111 DOI: 10.1523/Jneurosci.23-10-04228.2003 |
0.464 |
|
| 2002 |
Zhao L, Brinton RD. Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes. Brain Research. 943: 117-31. PMID 12088846 DOI: 10.1016/S0006-8993(02)02484-8 |
0.468 |
|
| 2002 |
Nilsen J, Brinton RD. Impact of progestins on estradiol potentiation of the glutamate calcium response. Neuroreport. 13: 825-30. PMID 11997695 DOI: 10.1097/00001756-200205070-00018 |
0.608 |
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| 2002 |
Nilsen J, Chen S, Brinton RD. Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway. Brain Research. 930: 216-34. PMID 11879813 DOI: 10.1016/S0006-8993(02)02254-0 |
0.6 |
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| 2002 |
Nilsen J, Brinton RD. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology. 143: 205-12. PMID 11751611 DOI: 10.1210/endo.143.1.8582 |
0.648 |
|
| 2002 |
Brinton RD. Selective estrogen receptor modulators (SERM) for the brain: Recent advances and remaining challenges for developing a NeuroSERM™ Drug Development Research. 56: 380-392. DOI: 10.1002/ddr.10090 |
0.409 |
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| 2001 |
Son MC, Brinton RD. Regulation and mechanism of L-type calcium channel activation via V1a vasopressin receptor activation in cultured cortical neurons. Neurobiology of Learning and Memory. 76: 388-402. PMID 11726244 DOI: 10.1006/Nlme.2001.4020 |
0.76 |
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| 2001 |
Brinton RD. Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges. Learning & Memory (Cold Spring Harbor, N.Y.). 8: 121-33. PMID 11390632 DOI: 10.1101/lm.39601 |
0.395 |
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| 2000 |
Chen Q, Patel R, Sales A, Oji G, Kim J, Monreal AW, Brinton RD. Vasopressin-induced neurotrophism in cultured neurons of the cerebral cortex: dependency on calcium signaling and protein kinase C activity. Neuroscience. 101: 19-26. PMID 11068133 DOI: 10.1016/S0306-4522(00)00323-7 |
0.317 |
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| 2000 |
Brinton RD, Chen S, Montoya M, Hsieh D, Minaya J. The estrogen replacement therapy of the Women's Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer's disease. Maturitas. 34: S35-52. PMID 10915920 DOI: 10.1016/S0378-5122(00)00107-9 |
0.413 |
|
| 1998 |
Son MC, Brinton RD. Vasopressin-induced calcium signaling in cultured cortical neurons. Brain Research. 793: 244-54. PMID 9630655 DOI: 10.1016/S0006-8993(98)00185-1 |
0.77 |
|
| 1998 |
Brinton RD, Yamazaki R, Gonzalez CM, O'Neill K, Schreiber SS. Vasopressin-induction of the immediate early gene, NGFI-A, in cultured hippocampal glial cells. Brain Research. Molecular Brain Research. 57: 73-85. PMID 9630527 DOI: 10.1016/S0169-328X(98)00069-2 |
0.323 |
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| 1998 |
Brinton RD, Yamazaki RS. Advances and challenges in the prevention and treatment of Alzheimer's disease Pharmaceutical Research. 15: 386-398. PMID 9563067 DOI: 10.1023/A:1011963929012 |
0.366 |
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| 1997 |
Brinton RD, Proffitt P, Tran J, Luu R. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Experimental Neurology. 147: 211-20. PMID 9344546 DOI: 10.1006/exnr.1997.6619 |
0.358 |
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| 1988 |
McEwen B, Chao H, Spencer R, Brinton R, Macisaac L, Harrelson A. Corticosteroid receptors in brain: relationship of receptors to effects in stress and aging. Annals of the New York Academy of Sciences. 512: 394-401. PMID 3327425 DOI: 10.1111/J.1749-6632.1987.Tb24975.X |
0.611 |
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