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Gemma Casadesus, PhD, Tufts University - Publications

Affiliations: 
Neuroscience Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Neuroscience
Website:
http://www.frontiersin.org/people/gemmacasadesus/3621

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Grizzanti J, Corrigan R, Servizi S, Casadesus G. Amylin Signaling in Diabetes and Alzheimer's Disease: Therapy or Pathology? Journal of Neurology & Neuromedicine. 4: 12-16. PMID 31511851 DOI: 10.29245/2572.942X/2019/1.1212  0.32
2019 Patrick S, Corrigan R, Grizzani J, Mey M, Blair J, Pallas M, Camins A, Lee HG, Casadesus G. Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer's Disease Are Associated with Oxidative Stress Regulation Mechanisms. Journal of Alzheimer's Disease : Jad. PMID 30958347 DOI: 10.3233/JAD-180421  0.96
2019 Blair JA, Bhatta S, Casadesus G. CNS luteinizing hormone receptor activation rescues ovariectomy-related loss of spatial memory and neuronal plasticity. Neurobiology of Aging. 78: 111-120. PMID 30925299 DOI: 10.1016/j.neurobiolaging.2019.02.002  0.36
2018 Bhatta S, Blair JA, Casadesus G. Luteinizing Hormone Involvement in Aging Female Cognition: Not All Is Estrogen Loss. Frontiers in Endocrinology. 9: 544. PMID 30319538 DOI: 10.3389/fendo.2018.00544  0.36
2018 Grizzanti J, Corrigan R, Casadesus G. Neuroprotective Effects of Amylin Analogues on Alzheimer's Disease Pathogenesis and Cognition. Journal of Alzheimer's Disease : Jad. PMID 30282360 DOI: 10.3233/JAD-180433  0.32
2018 Ettcheto M, Sánchez-López E, Gómez-Mínguez Y, Cabrera H, Busquets O, Beas-Zarate C, García ML, Carro E, Casadesus G, Auladell C, Vázquez Carrera M, Folch J, Camins A. Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer's Disease. Molecular Neurobiology. PMID 29404958 DOI: 10.1007/s12035-018-0868-4  0.72
2017 Folch J, Busquets O, Sánchez-López ME, Pallàs M, Beas-Zarate C, Marin M, Casadesus G, Olloquequi J, Auladell C, Camins A. Experimental models for aging and their potential for novel drug discovery. Current Neuropharmacology. PMID 28685671 DOI: 10.2174/1570159X15666170707155345  0.72
2016 Grizzanti J, Lee HG, Camins A, Pallas M, Casadesus G. The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer disease. Nutrition Research (New York, N.Y.). PMID 27923524 DOI: 10.1016/j.nutres.2016.11.002  0.96
2016 Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG. Correction: Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. Plos One. 11: e0157209. PMID 27258001 DOI: 10.1371/journal.pone.0157209  1
2016 Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG. Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. Plos One. 11: e0151615. PMID 26982086 DOI: 10.1371/journal.pone.0151615  1
2015 Blair JA, Palm R, Chang J, McGee H, Zhu X, Wang X, Smith GC. Luteinizing hormone downregulation but not estrogen replacement improves ovariectomy-associated cognition and spine density loss independently of treatment onset timing. Hormones and Behavior. PMID 26497249 DOI: 10.1016/j.yhbeh.2015.10.013  1
2015 Blair JA, Bhatta S, McGee H, Casadesus G. Luteinizing hormone: Evidence for direct action in the CNS. Hormones and Behavior. PMID 26172857 DOI: 10.1016/j.yhbeh.2015.06.020  0.36
2015 Petrov D, Pedrós I, Artiach G, Sureda FX, Barroso E, Pallàs M, Casadesús G, Beas-Zarate C, Carro E, Ferrer I, Vazquez-Carrera M, Folch J, Camins A. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochimica Et Biophysica Acta. 1852: 1687-1699. PMID 26003667 DOI: 10.1016/j.bbadis.2015.05.004  1
2015 Blair JA, McGee H, Bhatta S, Palm R, Casadesus G. Hypothalamic-pituitary-gonadal axis involvement in learning and memory and Alzheimer's disease: more than "just" estrogen. Frontiers in Endocrinology. 6: 45. PMID 25859241 DOI: 10.3389/fendo.2015.00045  1
2015 Petersen RB, Lissemore FM, Appleby B, Aggarwal N, Boyatzis R, Casadesus G, Cummings J, Jack A, Perry G, Safar J, Sajatovic M, Surewicz W, Wang Y, Whitehouse P, Lerner A. From Neurodegeneration to Brain Health: An Integrated Approach. Journal of Alzheimer's Disease : Jad. PMID 25720413 DOI: 10.3233/JAD-150043  1
2015 Blair JA, Bhatta S, McGee H, Casadesus G. Luteinizing hormone: Evidence for direct action in the CNS Hormones and Behavior. DOI: 10.1016/j.yhbeh.2015.06.020  1
2014 Pedrós I, Petrov D, Allgaier M, Sureda F, Barroso E, Beas-Zarate C, Auladell C, Pallàs M, Vázquez-Carrera M, Casadesús G, Folch J, Camins A. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Biochimica Et Biophysica Acta. 1842: 1556-66. PMID 24887203 DOI: 10.1016/j.bbadis.2014.05.025  1
2014 Yu S, Levi L, Casadesus G, Kunos G, Noy N. Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain. The Journal of Biological Chemistry. 289: 12748-58. PMID 24644281 DOI: 10.1074/jbc.M114.559062  1
2014 Palm R, Chang J, Blair J, Garcia-Mesa Y, Lee HG, Castellani RJ, Smith MA, Zhu X, Casadesus G. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. Journal of Neurochemistry. 130: 115-25. PMID 24601954 DOI: 10.1111/jnc.12706  1
2014 Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Research. 11: 317-24. PMID 24597504 DOI: 10.2174/1567205011666140302200902  1
2014 Adler BL, Yarchoan M, Hwang HM, Louneva N, Blair JA, Palm R, Smith MA, Lee HG, Arnold SE, Casadesus G. Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition. Neurobiology of Aging. 35: 793-801. PMID 24239383 DOI: 10.1016/j.neurobiolaging.2013.10.076  1
2014 Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. Journal of Neurochemistry. 128: 162-72. PMID 23895348 DOI: 10.1111/jnc.12380  1
2013 Loria CJ, Stevens AM, Crummy E, Casadesus G, Jacono FJ, Dick TE, Siegel RE. Respiratory and behavioral dysfunction following loss of the GABAA receptor α4 subunit. Brain and Behavior. 3: 104-13. PMID 23533098 DOI: 10.1002/brb3.122  1
2013 Porquet D, Casadesús G, Bayod S, Vicente A, Canudas AM, Vilaplana J, Pelegrí C, Sanfeliu C, Camins A, Pallàs M, del Valle J. Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8. Age (Dordrecht, Netherlands). 35: 1851-65. PMID 23129026 DOI: 10.1007/s11357-012-9489-4  0.72
2013 Correia SC, Santos RX, Santos MS, Casadesus G, Lamanna JC, Perry G, Smith MA, Moreira PI. Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease. Current Alzheimer Research. 10: 406-19. PMID 23061885 DOI: 10.2174/1567205011310040006  1
2013 Joseph JA, Casadesus G, Smith MA, Perry G, Shukitt-Hale B. Nutrients and Food Constituents in Cognitive Decline and Neurodegenerative Disease Nutrition in the Prevention and Treatment of Disease. 373-390. DOI: 10.1016/B978-0-12-391884-0.00020-2  1
2013 Bonda DJ, Castellani RJ, Lee HG, Tabaton M, Casadesus G, Perry G, Zhu X, Smith MA. Down syndrome and Alzheimer disease: A "multi-hit" hypothesis based on multiple contributing factors resulting in pleotrophic consequences Alzheimer's Disease Research Compendium. 183-193.  1
2013 Bonda DJ, Castellani RJ, Lee HG, Tabaton M, Casadesus G, Perry G, Zhu X, Smith MA. Down syndrome and Alzheimer disease: A "multi-hit" hypothesis based on multiple contributing factors resulting in pleotrophic consequences Alzheimer's Disease Research Compendium. 183-193.  1
2012 Casadesús G, Gutierrez-Cuesta J, Lee HG, Jiménez A, Tajes M, Ortuño-Sahagún D, Camins A, Smith MA, Pallàs M. Neuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8). Journal of Alzheimer's Disease : Jad. 30: 573-83. PMID 22451322 DOI: 10.3233/JAD-2012-120112  1
2012 Palm R, Ayala-Fontanez N, Garcia Y, Lee HG, Smith MA, Casadesus G. Neuroendocrinology-based therapy for Alzheimer's disease. Biofactors (Oxford, England). 38: 123-32. PMID 22438197 DOI: 10.1002/biof.1011  1
2012 Lerner AJ, Gustaw-Rothenberg K, Smyth S, Casadesus G. Retinoids for treatment of Alzheimer's disease. Biofactors (Oxford, England). 38: 84-9. PMID 22419567 DOI: 10.1002/biof.196  1
2012 Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, et al. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metabolism. 15: 311-23. PMID 22405069 DOI: 10.1016/j.cmet.2012.01.020  1
2012 Wang X, Snape M, Klann E, Stone JG, Singh A, Petersen RB, Castellani RJ, Casadesus G, Smith MA, Zhu X. Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. Journal of Neurochemistry. 121: 672-9. PMID 22393900 DOI: 10.1111/j.1471-4159.2012.07722.x  1
2012 Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, Perry G, Casadesus G, Zhu X. LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Human Molecular Genetics. 21: 1931-44. PMID 22228096 DOI: 10.1093/hmg/dds003  1
2012 Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X. Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. Journal of Neurochemistry. 120: 419-29. PMID 22077634 DOI: 10.1111/j.1471-4159.2011.07581.x  1
2012 Chang J, Rimando A, Pallas M, Camins A, Porquet D, Reeves J, Shukitt-Hale B, Smith MA, Joseph JA, Casadesus G. Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiology of Aging. 33: 2062-71. PMID 21982274 DOI: 10.1016/j.neurobiolaging.2011.08.015  1
2011 Stone JG, Casadesus G, Gustaw-Rothenberg K, Siedlak SL, Wang X, Zhu X, Perry G, Castellani RJ, Smith MA. Frontiers in Alzheimer's disease therapeutics. Therapeutic Advances in Chronic Disease. 2: 9-23. PMID 21743833 DOI: 10.1177/2040622310382817  1
2011 Koubeissi MZ, Rashid S, Casadesus G, Xu K, Syed TU, Lüders H, Durand D. Transection of CA3 does not affect memory performance in rats. Epilepsy & Behavior : E&B. 21: 267-70. PMID 21576037 DOI: 10.1016/j.yebeh.2011.04.006  1
2011 Bonda DJ, Lee HG, Camins A, Pallàs M, Casadesus G, Smith MA, Zhu X. The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. The Lancet. Neurology. 10: 275-9. PMID 21349442 DOI: 10.1016/S1474-4422(11)70013-8  1
2011 Chang J, Pallas M, Zhu X, Kim HJ, Camins A, Lee HG, Perry G, Smith MA, Casadesus G. Unveiling "the switch" from aging to Alzheimer's disease with the senescence-accelerated mouse model (SAMP8) Advances in Alzheimer's Disease. 1: 39-48. DOI: 10.3233/978-1-60750-733-8-39  1
2010 Casadesus G, Arendash G, Laferla F, McDonald M. Animal models of Alzheimer's disease. International Journal of Alzheimer's Disease. 2010: 606357. PMID 21804934 DOI: 10.4061/2010/606357  1
2010 Clark TA, Lee HP, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Casadesus G, Smith MA, Lee HG, Perry G. Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease. International Journal of Biomedical Science : Ijbs. 6: 225-227. PMID 21765811  1
2010 Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES. Pet-1 is required across different stages of life to regulate serotonergic function. Nature Neuroscience. 13: 1190-8. PMID 20818386 DOI: 10.1038/nn.2623  1
2010 Casadesus G. Special issue on estrogen actions in the brain. Biochimica Et Biophysica Acta. 1800: 1029. PMID 20800763 DOI: 10.1016/j.bbagen.2010.08.002  1
2010 Moreira PI, Santos RX, Zhu X, Lee HG, Smith MA, Casadesus G, Perry G. Autophagy in Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1209-18. PMID 20586699 DOI: 10.1586/ern.10.84  1
2010 Lee HP, Zhu X, Casadesus G, Castellani RJ, Nunomura A, Smith MA, Lee HG, Perry G. Antioxidant approaches for the treatment of Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1201-8. PMID 20586698 DOI: 10.1586/ern.10.74  1
2010 Galindo MF, Ikuta I, Zhu X, Casadesus G, Jordán J. Mitochondrial biology in Alzheimer's disease pathogenesis. Journal of Neurochemistry. 114: 933-45. PMID 20492350 DOI: 10.1111/j.1471-4159.2010.06814.x  1
2010 Kim HJ, Casadesus G. Estrogen-mediated effects on cognition and synaptic plasticity: what do estrogen receptor knockout models tell us? Biochimica Et Biophysica Acta. 1800: 1090-3. PMID 20470868 DOI: 10.1016/j.bbagen.2010.05.001  1
2010 Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 1155-67. PMID 20308782 DOI: 10.3233/JAD-2010-1308  1
2010 Del Valle J, Duran-Vilaregut J, Manich G, Casadesús G, Smith MA, Camins A, Pallàs M, Pelegrí C, Vilaplana J. Early amyloid accumulation in the hippocampus of SAMP8 mice. Journal of Alzheimer's Disease : Jad. 19: 1303-15. PMID 20061609 DOI: 10.3233/JAD-2010-1321  1
2010 Bonda DJ, Bajić VP, Spremo-Potparevic B, Casadesus G, Zhu X, Smith MA, Lee HG. Review: cell cycle aberrations and neurodegeneration. Neuropathology and Applied Neurobiology. 36: 157-63. PMID 20059701 DOI: 10.1111/j.1365-2990.2010.01064.x  1
2010 Tabaton M, Perry G, Zhu X, Lee HG, Casadesus G, Smith MA. Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease. The American Journal of Pathology. 176: 540-1. PMID 20019185 DOI: 10.2353/ajpath.2010.090856  1
2010 Bryan KJ, Mudd JC, Richardson SL, Chang J, Lee HG, Zhu X, Smith MA, Casadesus G. Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits. Journal of Neurochemistry. 112: 870-81. PMID 19943850 DOI: 10.1111/j.1471-4159.2009.06502.x  1
2010 Rodrigues R, Bonda DJ, Perry G, Castellani RJ, Casadesus G, Lee HG, Lee HP, Wang X, Zhu X, Petersen RB, Smith MA. Oxidative stress and neurodegeneration: An inevitable consequence of aging? Implications for therapy Brain Protection in Schizophrenia, Mood and Cognitive Disorders. 305-323. DOI: 10.1007/978-90-481-8553-5_10  1
2009 Cardoso S, Santos R, Correia S, Carvalho C, Zhu X, Lee HG, Casadesus G, Smith MA, Perry G, Moreira PI. Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets. Pharmaceuticals (Basel, Switzerland). 2: 250-286. PMID 27713238 DOI: 10.3390/ph2030250  1
2009 Friedlich AL, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA. Treatment advances in Alzheimer's disease based on the oxidative stress model. F1000 Medicine Reports. 1. PMID 20948726 DOI: 10.3410/M1-54  1
2009 Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. Chronic Leptin Supplementation Ameliorates Pathology and Improves Cognitive Performance in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 20009219 DOI: 10.3233/JAD-2009-1308  1
2009 Lee HP, Casadesus G, Zhu X, Lee HG, Perry G, Smith MA, Gustaw-Rothenberg K, Lerner A. All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. Expert Review of Neurotherapeutics. 9: 1615-21. PMID 19903021 DOI: 10.1586/ern.09.86  1
2009 Snape M, Lee HG, Casadesus G, Smith MA. Cell cycle aberrations in Alzheimer's disease: a novel therapeutic opportunity. Expert Review of Neurotherapeutics. 9: 1579-80. PMID 19903017 DOI: 10.1586/ern.09.113  1
2009 Smith MA, Casadesus G. Walking toward a convergence in aging research. Frontiers in Neuroscience. 3: 1. PMID 19753087 DOI: 10.3389/neuro.01.012.2009  1
2009 Bajić VP, Spremo-Potparević B, Zivković L, Bonda DJ, Siedlak SL, Casadesus G, Lee HG, Smith MA. The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging? Medical Hypotheses. 73: 917-20. PMID 19647374 DOI: 10.1016/j.mehy.2009.06.046  1
2009 Greco SJ, Sarkar S, Casadesus G, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neuroscience Letters. 455: 191-4. PMID 19429119 DOI: 10.1016/j.neulet.2009.03.066  1
2009 Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P. Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Investigative Ophthalmology & Visual Science. 50: 4368-78. PMID 19407008 DOI: 10.1167/iovs.09-3700  1
2009 Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 731-40. PMID 19387109 DOI: 10.3233/JAD-2009-1021  1
2009 Yeste-Velasco M, Folch J, Casadesús G, Smith MA, Pallàs M, Camins A. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience. 159: 1135-47. PMID 19356694 DOI: 10.1016/j.neuroscience.2009.01.035  1
2009 Pallàs M, Casadesús G, Smith MA, Coto-Montes A, Pelegri C, Vilaplana J, Camins A. Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection. Current Neurovascular Research. 6: 70-81. PMID 19355928  1
2009 Rajendran R, Minqin R, Ynsa MD, Casadesus G, Smith MA, Perry G, Halliwell B, Watt F. A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease. Biochemical and Biophysical Research Communications. 382: 91-5. PMID 19258010 DOI: 10.1016/j.bbrc.2009.02.136  1
2009 Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. The American Journal of Pathology. 174: 891-7. PMID 19164506 DOI: 10.2353/ajpath.2009.080583  1
2009 Tajes M, Yeste-Velasco M, Zhu X, Chou SP, Smith MA, Pallàs M, Camins A, Casadesús G. Activation of Akt by lithium: pro-survival pathways in aging. Mechanisms of Ageing and Development. 130: 253-61. PMID 19162061 DOI: 10.1016/j.mad.2008.12.006  1
2009 Siedlak SL, Casadesus G, Webber KM, Pappolla MA, Atwood CS, Smith MA, Perry G. Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease. Free Radical Research. 43: 156-64. PMID 19160110 DOI: 10.1080/10715760802644694  1
2009 Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochemistry International. 54: 84-8. PMID 19114068 DOI: 10.1016/j.neuint.2008.10.013  1
2009 Ramiro-Puig E, Casadesús G, Lee HG, Zhu X, McShea A, Perry G, Pérez-Cano FJ, Smith MA, Castell M. Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress. European Journal of Nutrition. 48: 54-61. PMID 19043659 DOI: 10.1007/s00394-008-0761-4  1
2009 Lee HG, Zhu X, Casadesus G, Pallàs M, Camins A, O'Neill MJ, Nakanishi S, Perry G, Smith MA. The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival. Brain Research. 1249: 244-50. PMID 19026996 DOI: 10.1016/j.brainres.2008.10.055  1
2009 Casadesus G, Bryan KJ, Perry G, Smith MA. Involvement of gonadotropins in cognitive function: Implications for Alzheimer's disease Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. 251-258. DOI: 10.1017/CBO9780511635700.027  1
2009 Marlatt MW, Moreira PI, Lee Hg, Casadesus G, Castellani RJ, Takeda A, Nunomura A, Zhu X, Perry G, Smith MA. Therapeutic opportunities in Alzheimer disease: Current concepts Frontiers in Medicinal Chemistry. 4: 767-788.  1
2008 Pallas M, Camins A, Smith MA, Perry G, Lee HG, Casadesus G. From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8). Journal of Alzheimer's Disease : Jad. 15: 615-24. PMID 19096160  1
2008 Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proceedings of the National Academy of Sciences of the United States of America. 105: 19318-23. PMID 19050078 DOI: 10.1073/pnas.0804871105  1
2008 McShea A, Ramiro-Puig E, Munro SB, Casadesus G, Castell M, Smith MA. Clinical benefit and preservation of flavonols in dark chocolate manufacturing. Nutrition Reviews. 66: 630-41. PMID 19019025 DOI: 10.1111/j.1753-4887.2008.00114.x  1
2008 Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G, Ashford JW, Smith MA, Tezapsidis N. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochemical and Biophysical Research Communications. 376: 536-41. PMID 18801339 DOI: 10.1016/j.bbrc.2008.09.026  1
2008 Bryan KJ, Zhu X, Harris PL, Perry G, Castellani RJ, Smith MA, Casadesus G. Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease. Molecular Neurodegeneration. 3: 13. PMID 18786268 DOI: 10.1186/1750-1326-3-13  1
2008 Thakur A, Siedlak SL, James SL, Bonda DJ, Rao A, Webber KM, Camins A, Pallàs M, Casadesus G, Lee HG, Bowser R, Raina AK, Perry G, Smith MA, Zhu X. Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. International Journal of Clinical and Experimental Pathology. 1: 134-46. PMID 18784806  1
2008 Tajes M, Gutierrez-Cuesta J, Folch J, Ferrer I, Caballero B, Smith MA, Casadesus G, Camins A, Pallás M. Lithium treatment decreases activities of tau kinases in a murine model of senescence. Journal of Neuropathology and Experimental Neurology. 67: 612-23. PMID 18520779 DOI: 10.1097/NEN.0b013e3181776293  1
2008 Casadesus G, Rolston RK, Webber KM, Atwood CS, Bowen RL, Perry G, Smith MA. Menopause, estrogen, and gonadotropins in Alzheimer's disease. Advances in Clinical Chemistry. 45: 139-53. PMID 18429496 DOI: 10.1016/S0065-2423(07)00006-6  1
2008 Pizarro JG, Yeste-Velasco M, Rimbau V, Casadesús G, Smith MA, Pallàs M, Folch J, Camins A. Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 26: 269-76. PMID 18342477 DOI: 10.1016/j.ijdevneu.2008.02.002  1
2008 Bryan K, Lee HG, Perry G, Castellani RJ, Smith MA, Casadesus G. Nonestrogen-based hormonal therapies for Alzheimer's disease Future Neurology. 3: 399-407. DOI: 10.2217/14796708.3.4.399  1
2007 Webber KM, Casadesus G, Bowen RL, Perry G, Smith MA. Evidence for the role of luteinizing hormone in Alzheimer disease. Endocrine, Metabolic & Immune Disorders Drug Targets. 7: 300-3. PMID 18220951 DOI: 10.2174/187153007782794326  1
2007 Webber KM, Perry G, Smith MA, Casadesus G. The contribution of luteinizing hormone to Alzheimer disease pathogenesis. Clinical Medicine & Research. 5: 177-83. PMID 18056027 DOI: 10.3121/cmr.2007.741  1
2007 Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. The Journal of Biological Chemistry. 282: 32844-55. PMID 17716967 DOI: 10.1074/jbc.M706127200  1
2007 Pelegrí C, Canudas AM, del Valle J, Casadesus G, Smith MA, Camins A, Pallàs M, Vilaplana J. Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence. Mechanisms of Ageing and Development. 128: 522-8. PMID 17697702 DOI: 10.1016/j.mad.2007.07.002  1
2007 Alvira D, Yeste-Velasco M, Folch J, Casadesús G, Smith MA, Pallàs M, Camins A. Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons. Journal of Neuroscience Research. 85: 3079-88. PMID 17638302 DOI: 10.1002/jnr.21427  1
2007 Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA, Zhu X. Signal transduction cascades associated with oxidative stress in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 11: 143-52. PMID 17522439  1
2007 Casadesus G, Milliken EL, Webber KM, Bowen RL, Lei Z, Rao CV, Perry G, Keri RA, Smith MA. Increases in luteinizing hormone are associated with declines in cognitive performance. Molecular and Cellular Endocrinology. 269: 107-11. PMID 17376589 DOI: 10.1016/j.mce.2006.06.013  1
2007 Casadesus G, Moreira PI, Nunomura A, Siedlak SL, Bligh-Glover W, Balraj E, Petot G, Smith MA, Perry G. Indices of metabolic dysfunction and oxidative stress. Neurochemical Research. 32: 717-22. PMID 17342408 DOI: 10.1007/s11064-007-9296-y  1
2007 Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadesus G, Harris PL, Siedlak SL, Perry G. Vascular oxidative stress in Alzheimer disease. Journal of the Neurological Sciences. 257: 240-6. PMID 17337008 DOI: 10.1016/j.jns.2007.01.039  1
2007 Casadesus G, Smith MA, Basu S, Hua J, Capobianco DE, Siedlak SL, Zhu X, Perry G. Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. Molecular Neurodegeneration. 2: 2. PMID 17241462 DOI: 10.1186/1750-1326-2-2  1
2007 McShea A, Lee HG, Petersen RB, Casadesus G, Vincent I, Linford NJ, Funk JO, Shapiro RA, Smith MA. Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochimica Et Biophysica Acta. 1772: 467-72. PMID 17095196 DOI: 10.1016/j.bbadis.2006.09.010  1
2007 Webber KM, Casadesus G, Atwood CS, Bowen RL, Perry G, Smith MA. Gonadotropins: a cohesive gender-based etiology of Alzheimer disease. Molecular and Cellular Endocrinology. 260: 271-5. PMID 17052835 DOI: 10.1016/j.mce.2006.01.018  1
2007 Shukitt-Hale B, Casadesus G, Carey AN, Rabin BM, Joseph JA. Exposure to 56Fe irradiation accelerates normal brain aging and produces deficits in spatial learning and memory Advances in Space Research. 39: 1087-1092. DOI: 10.1016/j.asr.2006.11.005  1
2007 Moreira PI, Nunomura A, Honda K, Aliev G, Casadesus G, Zhu X, Smith MA, Perry G. The key role of oxidative stress in alzheimer's disease Oxidative Stress and Neurodegenerative Disorders. 267-281. DOI: 10.1016/B978-044452809-4/50153-8  1
2006 Casadesus G, Puig ER, Webber KM, Atwood CS, Escuer MC, Bowen RL, Perry G, Smith MA. Targeting gonadotropins: an alternative option for Alzheimer disease treatment. Journal of Biomedicine & Biotechnology. 2006: 39508. PMID 17047306 DOI: 10.1155/JBB/2006/39508  1
2006 Webber KM, Stocco DM, Casadesus G, Bowen RL, Atwood CS, Previll LA, Harris PL, Zhu X, Perry G, Smith MA. Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease. Molecular Neurodegeneration. 1: 14. PMID 17018137 DOI: 10.1186/1750-1326-1-14  1
2006 Forero DA, Casadesus G, Perry G, Arboleda H. Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. Journal of Cellular and Molecular Medicine. 10: 796-805. PMID 16989739 DOI: 10.1111/j.1582-4934.2006.tb00439.x  1
2006 Casadesus G, Garrett MR, Webber KM, Hartzler AW, Atwood CS, Perry G, Bowen RL, Smith MA. The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease. Drugs in R&D. 7: 187-93. PMID 16752944 DOI: 10.2165/00126839-200607030-00004  1
2006 Casadesus G, Webber KM, Atwood CS, Pappolla MA, Perry G, Bowen RL, Smith MA. Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice. Biochimica Et Biophysica Acta. 1762: 447-52. PMID 16503402 DOI: 10.1016/j.bbadis.2006.01.008  1
2006 Webber KM, Casadesus G, Zhu X, Obrenovich ME, Atwood CS, Perry G, Bowen RL, Smith MA. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Current Pharmaceutical Design. 12: 691-7. PMID 16472159 DOI: 10.2174/138161206775474305  1
2006 Moreira PI, Honda K, Zhu X, Nunomura A, Casadesus G, Smith MA, Perry G. Brain and brawn: parallels in oxidative strength. Neurology. 66: S97-101. PMID 16432155 DOI: 10.1212/01.wnl.0000192307.15103.83  1
2006 Castellani RJ, Zhu X, Lee HG, Perry G, Smith MA, Casadesus G. Neurogenesis in human hippocampus: Implications for Alzheimer disease pathogenesis Neuroembryology and Aging. 4: 175-182. DOI: 10.1159/000118927  1
2006 Raina AK, Garrett MR, Previll LA, Obrenovich ME, Hartzler AW, Webber KM, Casadesus G, Lee HG, Perry G, Zhu X, Smith MA. Oncogenic parallels in Alzheimer disease International Journal of Neuroprotection and Neuroregeneration. 2: 80-85.  1
2005 Casadesus G, Smith MA, Perry G. Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, and Luigi Puglielli. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 51-2. PMID 19595817 DOI: 10.1016/j.jalz.2005.06.011  1
2005 Joseph JA, Shukitt-Hale B, Casadesus G, Fisher D. Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochemical Research. 30: 927-35. PMID 16187227 DOI: 10.1007/s11064-005-6967-4  1
2005 Webber KM, Casadesus G, Marlatt MW, Perry G, Hamlin CR, Atwood CS, Bowen RL, Smith MA. Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis. Annals of the New York Academy of Sciences. 1052: 201-9. PMID 16024763 DOI: 10.1196/annals.1347.020  1
2005 Zhu X, Lee HG, Casadesus G, Avila J, Drew K, Perry G, Smith MA. Oxidative imbalance in Alzheimer's disease. Molecular Neurobiology. 31: 205-17. PMID 15953822 DOI: 10.1385/MN:31:1-3:205  1
2005 Webber KM, Casadesus G, Perry G, Atwood CS, Bowen R, Smith MA. Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis. Alzheimer Disease and Associated Disorders. 19: 95-9. PMID 15942328 DOI: 10.1097/01.wad.0000165512.90864.3f  1
2005 Webber KM, Raina AK, Marlatt MW, Zhu X, Prat MI, Morelli L, Casadesus G, Perry G, Smith MA. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mechanisms of Ageing and Development. 126: 1019-25. PMID 15936057 DOI: 10.1016/j.mad.2005.03.024  1
2005 Marlatt MW, Webber KM, Moreira PI, Lee HG, Casadesus G, Honda K, Zhu X, Perry G, Smith MA. Therapeutic opportunities in Alzheimer disease: one for all or all for one? Current Medicinal Chemistry. 12: 1137-47. PMID 15892629 DOI: 10.2174/0929867053764644  1
2005 Casadesus G, Shukitt-Hale B, Stellwagen HM, Smith MA, Rabin BM, Joseph JA. Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats. Experimental Gerontology. 40: 249-54. PMID 15763403 DOI: 10.1016/j.exger.2004.09.007  1
2005 Casadesus G, Atwood CS, Zhu X, Hartzler AW, Webber KM, Perry G, Bowen RL, Smith MA. Evidence for the role of gonadotropin hormones in the development of Alzheimer disease. Cellular and Molecular Life Sciences : Cmls. 62: 293-8. PMID 15723165 DOI: 10.1007/s00018-004-4384-0  1
2005 Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. The American Journal of Clinical Nutrition. 81: 313S-316S. PMID 15640496  1
2005 Rajendran R, Ren M, Casadesus G, Smith MA, Perry G, Huang E, Ong WY, Halliwell B, Watt F. Nuclear microscopy of diffuse plaques in the brains of transgenic mice Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions With Materials and Atoms. 231: 326-332. DOI: 10.1016/j.nimb.2005.01.078  1
2004 Casadesus G, Shukitt-Hale B, Cantuti-Castelvetri I, Rabin BM, Joseph JA. The effects of heavy particle irradiation on exploration and response to environmental change. Advances in Space Research : the Official Journal of the Committee On Space Research (Cospar). 33: 1340-6. PMID 15803625 DOI: 10.1016/j.asr.2003.12.011  1
2004 Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, Joseph JA. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutritional Neuroscience. 7: 309-16. PMID 15682927 DOI: 10.1080/10284150400020482  1
2004 Casadesus G, Zhu X, Atwood CS, Webber KM, Perry G, Bowen RL, Smith MA. Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease. Current Drug Targets. Cns and Neurological Disorders. 3: 281-5. PMID 15379604 DOI: 10.2174/1568007043337265  1
2004 Zhu X, Webber KM, Casadesus G, Raina AK, Lee HG, Marlatt M, Hartzler A, Atwood CS, Perry G, Smith MA. Mitotic and gender parallels in Alzheimer disease: therapeutic opportunities. Current Drug Targets. 5: 559-63. PMID 15270202 DOI: 10.2174/1389450043345317  1
2004 Lee HG, Casadesus G, Zhu X, Takeda A, Perry G, Smith MA. Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Annals of the New York Academy of Sciences. 1019: 1-4. PMID 15246983 DOI: 10.1196/annals.1297.001  1
2004 Webber KM, Bowen R, Casadesus G, Perry G, Atwood CS, Smith MA. Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotection. Acta Neurobiologiae Experimentalis. 64: 113-8. PMID 15190686  1
2004 Lee HG, Zhu X, O'Neill MJ, Webber K, Casadesus G, Marlatt M, Raina AK, Perry G, Smith MA. The role of metabotropic glutamate receptors in Alzheimer's disease. Acta Neurobiologiae Experimentalis. 64: 89-98. PMID 15190683  1
2004 Honda K, Casadesus G, Petersen RB, Perry G, Smith MA. Oxidative stress and redox-active iron in Alzheimer's disease. Annals of the New York Academy of Sciences. 1012: 179-82. PMID 15105265 DOI: 10.1196/annals.1306.015  1
2004 Casadesus G, Smith MA, Zhu X, Aliev G, Cash AD, Honda K, Petersen RB, Perry G. Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. Journal of Alzheimer's Disease : Jad. 6: 165-9. PMID 15096700  1
2004 Lee HG, Casadesus G, Zhu X, Joseph JA, Perry G, Smith MA. Perspectives on the amyloid-beta cascade hypothesis. Journal of Alzheimer's Disease : Jad. 6: 137-45. PMID 15096697  1
2004 Zhu X, Raina AK, Lee HG, Casadesus G, Smith MA, Perry G. Oxidative stress signalling in Alzheimer's disease. Brain Research. 1000: 32-9. PMID 15053949 DOI: 10.1016/j.brainres.2004.01.012  1
2003 Perry G, Nunomura A, Raina AK, Aliev G, Siedlak SL, Harris PL, Casadesus G, Petersen RB, Bligh-Glover W, Balraj E, Petot GJ, Smith MA. A metabolic basis for Alzheimer disease. Neurochemical Research. 28: 1549-52. PMID 14570400 DOI: 10.1023/A:1025678510480  1
2003 Shukitt-Hale B, Casadesus G, Cantuti-Castelvetri I, Rabin BM, Joseph JA. Cognitive deficits induced by 56Fe radiation exposure. Advances in Space Research : the Official Journal of the Committee On Space Research (Cospar). 31: 119-26. PMID 12577981 DOI: 10.1016/S0273-1177(02)00878-5  1
2003 Perry G, Ávila J, Casadesus G, Nunomura A, Tabaton M, Cash A, Aliev G, Wataya T, Shimohama S, Drew K, Atwood C, Smith M. The role of oxidative stress in the pathogenesis of Alzheimer's disease | La función del estrés oxidativo en la patogénesis de la enfermedad de Alzheimer Revista Chilena De Neuro-Psiquiatria. 41: 47-52.  1
2002 Smith MA, Casadesus G, Joseph JA, Perry G. Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radical Biology & Medicine. 33: 1194-9. PMID 12398927 DOI: 10.1016/S0891-5849(02)01021-3  1
2002 Casadesus G, Shukitt-Hale B, Joseph JA. Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging? Neurobiology of Aging. 23: 747-69. PMID 12392779 DOI: 10.1016/S0197-4580(02)00079-9  1
2001 Shukitt-Hale B, Casadesus G, Cantuti-Castelvetri I, Joseph JA. Effect of age on object exploration, habituation, and response to spatial and nonspatial change. Behavioral Neuroscience. 115: 1059-64. PMID 11584918 DOI: 10.1037/0735-7044.115.5.1059  1
2001 Casadesus G, Shukitt-Hale B, Joseph JA. Automated measurement of age-related changes in the locomotor response to environmental novelty and home-cage activity. Mechanisms of Ageing and Development. 122: 1887-97. PMID 11557287 DOI: 10.1016/S0047-6374(01)00324-4  1
2000 Shukitt-Hale B, Casadesus G, McEwen JJ, Rabin BM, Joseph JA. Spatial learning and memory deficits induced by exposure to iron-56-particle radiation. Radiation Research. 154: 28-33. PMID 10856962  1
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