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Morgan A. Huse, Ph.D. - Publications

Affiliations: 
2001 Rockefeller University, New York, NY, United States 
Area:
Structural Biology of Cellular Signal Transduction and DNA Replication
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41/69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sanchez EE, Tello-Lafoz M, Guo AJ, de Jesus M, Elbanna YA, Winer BY, Budhu S, Chan E, Rosiek E, Kondo T, DuSold J, Taylor N, Altan-Bonnet G, Olson MF, Huse M. Apoptotic contraction drives target cell release by cytotoxic T cells. Nature Immunology. PMID 37500886 DOI: 10.1038/s41590-023-01572-4  0.602
2023 de Jesus M, Settle AH, Vorselen D, Gaetjens TK, Galiano M, Wong YY, Fu TM, Santosa E, Winer BY, Tamzalit F, Wang MS, Bao Z, Sun JC, Shah P, Theriot JA, ... ... Huse M, et al. Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis. Biorxiv : the Preprint Server For Biology. PMID 37131635 DOI: 10.1101/2023.04.16.537078  0.307
2022 Mansilla-Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, Paillon N, Zucchetti AE, Li Z, Sjöstrand M, Lindenbergh PL, Saetersmoen M, Dobrin A, Maurin M, Iyer A, Garcia Angus A, ... ... Huse M, et al. HLA-independent T cell receptors for targeting tumors with low antigen density. Nature Medicine. PMID 35027758 DOI: 10.1038/s41591-021-01621-1  0.321
2020 Chaudhuri PK, Wang MS, Black CT, Huse M, Kam LC. Modulating T Cell Activation Using Depth Sensing Topographic Cues. Advanced Biosystems. e2000143. PMID 32744809 DOI: 10.1002/adbi.202000143  0.372
2020 Tamzalit F, Tran D, Jin W, Boyko V, Bazzi H, Kepecs A, Kam LC, Anderson KV, Huse M. Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing. Proceedings of the National Academy of Sciences of the United States of America. PMID 32041868 DOI: 10.1073/pnas.1913220117  0.308
2019 Jin W, Tamzalit F, Chaudhuri PK, Black CT, Huse M, Kam LC. T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces. Proceedings of the National Academy of Sciences of the United States of America. PMID 31527238 DOI: 10.1073/Pnas.1906986116  0.343
2019 Sanchez E, Liu X, Huse M. Actin clearance promotes polarized dynein accumulation at the immunological synapse. Plos One. 14: e0210377. PMID 31269031 DOI: 10.1371/journal.pone.0210377  0.348
2019 Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, Mansilla-Soto J, Eyquem J, Zhao Z, Whitlock BM, Miele MM, Li Z, Cunanan KM, Huse M, Hendrickson RC, Wang X, et al. CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. Nature. PMID 30918399 DOI: 10.1038/S41586-019-1054-1  0.35
2019 Tamzalit F, Wang MS, Jin W, Tello-Lafoz M, Boyko V, Heddleston JM, Black CT, Kam LC, Huse M. Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells. Science Immunology. 4. PMID 30902904 DOI: 10.1126/Sciimmunol.Aav5445  0.323
2018 Sanchez E, Huse M. Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist. Journal of Visualized Experiments : Jove. PMID 29757266 DOI: 10.3791/56655  0.364
2017 Tello-Lafoz M, Martínez-Martínez G, Rodríguez-Rodríguez C, Albar JP, Huse M, Gharbi S, Merida I. Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse. Traffic (Copenhagen, Denmark). 18: 491-504. PMID 28477369 DOI: 10.1111/tra.12492  0.358
2017 Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity. PMID 28389069 DOI: 10.1016/J.Immuni.2017.03.011  0.559
2017 Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M. Correction: Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. The Journal of Experimental Medicine. PMID 28292823 DOI: 10.1084/Jem.2013132403102017C  0.543
2016 Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, Toure A, Pritykin Y, Huse M, Leslie CS, Li MO. Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell. PMID 26806130 DOI: 10.1016/J.Cell.2016.01.002  0.306
2014 Le Floc'h A, Huse M. Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse. Cellular and Molecular Life Sciences : Cmls. 72: 537-556. PMID 25355055 DOI: 10.1007/s00018-014-1760-7  0.347
2014 Chauveau A, Le Floc'h A, Bantilan NS, Koretzky GA, Huse M. Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse. Science Signaling. 7: ra82. PMID 25161317 DOI: 10.1126/Scisignal.2005287  0.354
2014 Huse M, Le Floc'h A, Liu X. From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells. Immunological Reviews. 256: 95-106. PMID 24117815 DOI: 10.1111/imr.12116  0.331
2013 Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M. Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. The Journal of Experimental Medicine. 210: 2721-37. PMID 24190432 DOI: 10.1085/Jgp.1426Oia47  0.625
2013 Liu X, Kapoor TM, Chen JK, Huse M. Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II. Proceedings of the National Academy of Sciences of the United States of America. 110: 11976-81. PMID 23818610 DOI: 10.1073/Pnas.1306180110  0.372
2013 Gasteiger G, Hemmers S, Firth MA, Le Floc'h A, Huse M, Sun JC, Rudensky AY. IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. The Journal of Experimental Medicine. 210: 1167-78. PMID 23650441 DOI: 10.1084/Jem.20122462  0.313
2012 Ouyang W, Liao W, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ, et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 491: 554-9. PMID 23135404 DOI: 10.1038/Nature11581  0.353
2012 Merino E, Abeyweera TP, Firth MA, Zawislak CL, Basu R, Liu X, Sun JC, Huse M. Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells. Journal of Immunology (Baltimore, Md. : 1950). 189: 4859-69. PMID 23077238 DOI: 10.4049/jimmunol.1200825  0.329
2012 Huse M. Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond. Frontiers in Immunology. 3: 235. PMID 23060874 DOI: 10.3389/fimmu.2012.00235  0.38
2011 Huse M. Lymphocyte polarity, the immunological synapse and the scope of biological analogy. Bioarchitecture. 1: 180-185. PMID 22069511 DOI: 10.4161/bioa.1.4.17594  0.326
2011 Quann EJ, Liu X, Altan-Bonnet G, Huse M. A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells. Nature Immunology. 12: 647-54. PMID 21602810 DOI: 10.1038/Ni.2033  0.643
2010 Huse M. Photochemical approaches to T-cell activation. Immunology. 130: 151-7. PMID 20406301 DOI: 10.1111/j.1365-2567.2010.03267.x  0.341
2010 Kuhns MS, Girvin AT, Klein LO, Chen R, Jensen KD, Newell EW, Huppa JB, Lillemeier BF, Huse M, Chien YH, Garcia KC, Davis MM. Evidence for a functional sidedness to the alphabetaTCR. Proceedings of the National Academy of Sciences of the United States of America. 107: 5094-9. PMID 20202921 DOI: 10.1073/Pnas.1000925107  0.518
2009 Quann EJ, Merino E, Furuta T, Huse M. Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells. Nature Immunology. 10: 627-35. PMID 19430478 DOI: 10.1038/ni.1734  0.323
2008 Huse M, Quann EJ, Davis MM. Shouts, whispers and the kiss of death: directional secretion in T cells. Nature Immunology. 9: 1105-11. PMID 18800163 DOI: 10.1038/Ni.F.215  0.517
2007 Huse M, Klein LO, Girvin AT, Faraj JM, Li QJ, Kuhns MS, Davis MM. Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity. 27: 76-88. PMID 17629516 DOI: 10.1016/J.Immuni.2007.05.017  0.553
2007 Davis MM, Krogsgaard M, Huse M, Huppa J, Lillemeier BF, Li QJ. T cells as a self-referential, sensory organ. Annual Review of Immunology. 25: 681-95. PMID 17291190 DOI: 10.1146/Annurev.Immunol.24.021605.090600  0.488
2006 Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. T cells use two directionally distinct pathways for cytokine secretion. Nature Immunology. 7: 247-55. PMID 16444260 DOI: 10.1038/Ni1304  0.595
2005 Krogsgaard M, Li QJ, Sumen C, Huppa JB, Huse M, Davis MM. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature. 434: 238-43. PMID 15724150 DOI: 10.1038/Nature03391  0.674
2004 Ottesen JJ, Huse M, Sekedat MD, Muir TW. Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase. Biochemistry. 43: 5698-706. PMID 15134444 DOI: 10.1021/Bi0498407  0.384
2002 Huse M, Kuriyan J. The conformational plasticity of protein kinases. Cell. 109: 275-82. PMID 12015977 DOI: 10.1016/S0092-8674(02)00741-9  0.559
2002 Flavell RR, Huse M, Goger M, Trester-Zedlitz M, Kuriyan J, Muir TW. Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor. Organic Letters. 4: 165-8. PMID 11796041 DOI: 10.1021/Ol016859I  0.529
2001 Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massagué J, Shi Y. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Molecular Cell. 8: 1277-89. PMID 11779503 DOI: 10.1016/S1097-2765(01)00421-X  0.395
2001 Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massagué J. The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Molecular Cell. 8: 671-82. PMID 11583628 DOI: 10.1016/S1097-2765(01)00332-X  0.55
2000 Huse M, Holford MN, Kuriyan J, Muir TW. Semisynthesis of hyperphosphorylated type I TGFβ receptor: Addressing the mechanism of kinase activation [20] Journal of the American Chemical Society. 122: 8337-8338. DOI: 10.1021/Ja001763P  0.543
1999 Huse M, Chen YG, Massagué J, Kuriyan J. Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell. 96: 425-36. PMID 10025408 DOI: 10.1016/S0092-8674(00)80555-3  0.566
1997 Moarefi I, LaFevre-Bernt M, Sicheri F, Huse M, Lee CH, Kuriyan J, Miller WT. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement Nature. 385: 650-653. PMID 9024665 DOI: 10.1038/385650A0  0.638
Low-probability matches (unlikely to be authored by this person)
2014 Basu R, Chen Y, Quann EJ, Huse M. The variable hinge region of novel PKCs determines localization to distinct regions of the immunological synapse. Plos One. 9: e95531. PMID 24751783 DOI: 10.1371/journal.pone.0095531  0.297
2014 Bashour KT, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC. CD28 and CD3 have complementary roles in T-cell traction forces. Proceedings of the National Academy of Sciences of the United States of America. 111: 2241-6. PMID 24469820 DOI: 10.1073/Pnas.1315606111  0.296
2022 Shakiba M, Zumbo P, Espinosa-Carrasco G, Menocal L, Dündar F, Carson SE, Bruno EM, Sanchez-Rivera FJ, Lowe SW, Camara S, Koche RP, Reuter VP, Socci ND, Whitlock B, Tamzalit F, ... Huse M, et al. TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion. The Journal of Experimental Medicine. 219. PMID 34935874 DOI: 10.1084/jem.20201966  0.288
2020 Santich BH, Park JA, Tran H, Guo HF, Huse M, Cheung NV. Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies. Science Translational Medicine. 12. PMID 32161106 DOI: 10.1126/Scitranslmed.Aax1315  0.287
2022 Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, ... Huse M, et al. Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity. Nature Communications. 13: 3222. PMID 35680882 DOI: 10.1038/s41467-022-30809-3  0.272
2016 Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. PMID 26924577 DOI: 10.1016/J.Cell.2016.01.021  0.267
2009 Huse M. The T-cell-receptor signaling network. Journal of Cell Science. 122: 1269-73. PMID 19386893 DOI: 10.1242/jcs.042762  0.266
2015 Xu H, Cheng M, Guo H, Chen Y, Huse M, Cheung NK. Retargeting T cells to GD2 pentasaccharide on human tumors using Bispecific humanized antibody. Cancer Immunology Research. 3: 266-77. PMID 25542634 DOI: 10.1158/2326-6066.Cir-14-0230-T  0.266
2015 Huse M. Lipid-based patterning of the immunological synapse. Biochemical Society Transactions. 42: 1506-11. PMID 25399561 DOI: 10.1042/BST20140191  0.261
2022 Wang MS, Huse M. Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse. The Journal of Cell Biology. 221. PMID 35969858 DOI: 10.1083/jcb.202208015  0.246
2017 Huse M. Mechanical forces in the immune system. Nature Reviews. Immunology. 17: 679-690. PMID 28757604 DOI: 10.1038/nri.2017.74  0.242
2013 Huse M, Catherine Milanoski S, Abeyweera TP. Building tolerance by dismantling synapses: inhibitory receptor signaling in natural killer cells. Immunological Reviews. 251: 143-53. PMID 23278746 DOI: 10.1111/imr.12014  0.238
2013 Abeyweera TP, Kaissar M, Huse M. Inhibitory receptor signaling destabilizes immunological synapse formation in primary NK cells. Frontiers in Immunology. 4: 410. PMID 24348477 DOI: 10.3389/fimmu.2013.00410  0.237
2021 Tello-Lafoz M, Srpan K, Sanchez EE, Hu J, Remsik J, Romin Y, Calò A, Hoen D, Bhanot U, Morris L, Boire A, Hsu KC, Massagué J, Huse M, Er EE. Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. Immunity. PMID 33756102 DOI: 10.1016/j.immuni.2021.02.020  0.228
2019 Adams NM, Geary CD, Santosa EK, Lumaquin D, Le Luduec JB, Sottile R, van der Ploeg K, Hsu J, Whitlock BM, Jackson BT, Weizman OE, Huse M, Hsu KC, Sun JC. Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells. Immunity. PMID 31103381 DOI: 10.1016/j.immuni.2019.04.009  0.226
2011 Abeyweera TP, Merino E, Huse M. Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells. The Journal of Cell Biology. 192: 675-90. PMID 21339333 DOI: 10.1083/jcb.201009135  0.213
2021 Zhang M, Zhao Z, Pritykin Y, Hannum M, Scott AC, Kuo F, Sanghvi V, Chan TA, Seshan V, Wendel HG, Schietinger A, Sadelain M, Huse M. Ectopic activation of the miR-200c-EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy. Science Translational Medicine. 13: eabg4328. PMID 34524864 DOI: 10.1126/scitranslmed.abg4328  0.211
2002 Huse M. Structural biology: alive and skiing. Structure. 10: 137-138. PMID 11839298 DOI: 10.1016/S0969-2126(02)00714-1  0.206
2016 Basu R, Huse M. Mechanical Communication at the Immunological Synapse. Trends in Cell Biology. PMID 27986534 DOI: 10.1016/j.tcb.2016.10.005  0.204
2023 Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, ... Huse M, et al. Author Correction: Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity. Nature Communications. 14: 8401. PMID 38110360 DOI: 10.1038/s41467-023-44258-z  0.199
2015 Duc TN, Huse M. A Generalizable Platform for the Photoactivation of Cell Surface Receptors. Acs Chemical Biology. 10: 2435-40. PMID 26295186 DOI: 10.1021/acschembio.5b00372  0.199
2021 Tello-Lafoz M, de Jesus MM, Huse M. Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert. Trends in Immunology. 43: 96-105. PMID 34973924 DOI: 10.1016/j.it.2021.12.003  0.197
2016 Cheng M, Santich BH, Xu H, Ahmed M, Huse M, Cheung NK. Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors. Oncoimmunology. 5: e1168557. PMID 27471647 DOI: 10.1080/2162402X.2016.1168557  0.189
2022 Er EE, Tello-Lafoz M, Huse M. Mechanoregulation of Metastasis Beyond The Matrix. Cancer Research. PMID 35877197 DOI: 10.1158/0008-5472.CAN-22-0419  0.178
2013 Pittari G, Liu XR, Selvakumar A, Zhao Z, Merino E, Huse M, Chewning JH, Hsu KC, Dupont B. NK cell tolerance of self-specific activating receptor KIR2DS1 in individuals with cognate HLA-C2 ligand. Journal of Immunology (Baltimore, Md. : 1950). 190: 4650-60. PMID 23554313 DOI: 10.4049/jimmunol.1202120  0.176
2017 Jin W, Black CT, Kam LC, Huse M. Probing Synaptic Biomechanics Using Micropillar Arrays. Methods in Molecular Biology (Clifton, N.J.). 1584: 333-346. PMID 28255710 DOI: 10.1007/978-1-4939-6881-7_19  0.167
2023 Winer BY, Settle AH, Yakimov AM, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh A, Sepp AL, Galiano M, Wong YY, Perry JSA, Geissmann F, Cross J, Zhou T, ... ... Huse M, et al. Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells. Biorxiv : the Preprint Server For Biology. PMID 37745515 DOI: 10.1101/2023.09.12.556572  0.141
2020 Vorselen D, Wang Y, de Jesus MM, Shah PK, Footer MJ, Huse M, Cai W, Theriot JA. Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell-target interactions. Nature Communications. 11: 20. PMID 31911639 DOI: 10.1038/S41467-019-13804-Z  0.097
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