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James K. Chen - Publications

Affiliations: 
Chemical and Systems Biology Stanford University, Palo Alto, CA 
Area:
chemical biology, developmental biology
Website:
http://chen.stanford.edu
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92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhang M, Chapman M, Sarode BR, Xiong B, Liang H, Chen JK, Weerapana E, Morken JP. Catalytic asymmetric synthesis of meta benzene isosteres. Nature. PMID 39169193 DOI: 10.1038/s41586-024-07865-4  0.498
2022 Pattanayak S, Sarode BR, Deiters A, Chen JK. Bicyclic Caged Morpholino Oligonucleotides for Optical Gene Silencing. Chembiochem : a European Journal of Chemical Biology. PMID 36068175 DOI: 10.1002/cbic.202200374  0.769
2022 Feng Z, Hom ME, Bearrood TE, Rosenthal ZC, Fernández D, Ondrus AE, Gu Y, McCormick AK, Tomaske MG, Marshall CR, Kline T, Chen CH, Mochly-Rosen D, Kuo CJ, Chen JK. Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nature Chemical Biology. PMID 35788181 DOI: 10.1038/s41589-022-01048-w  0.708
2020 Chen J, Malone B, Llewellyn E, Grasso M, Shelton PMM, Olinares PDB, Maruthi K, Eng ET, Vatandaslar H, Chait BT, Kapoor TM, Darst SA, Campbell EA. Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell. PMID 32783916 DOI: 10.1016/J.Cell.2020.07.033  0.493
2020 Cho U, Chen JK. Lanthanide-Based Optical Probes of Biological Systems. Cell Chemical Biology. PMID 32735780 DOI: 10.1016/J.Chembiol.2020.07.009  0.765
2020 Chen J, Malone B, Llewellyn E, Grasso M, Shelton PMM, Olinares PDB, Maruthi K, Eng ET, Vatandaslar H, Chait B, Kapoor T, Darst SA, Campbell EA. Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex. Biorxiv : the Preprint Server For Biology. PMID 32676607 DOI: 10.1101/2020.07.08.194084  0.495
2020 Ciepla P, Cho U, Chen JK. trLRET microscopy: Ultrasensitive imaging of lanthanide luminophores. Methods in Enzymology. 640: 225-248. PMID 32560800 DOI: 10.1016/Bs.Mie.2020.04.030  0.767
2020 Mruk K, Ciepla P, Piza PA, Alnaqib MA, Chen JK. Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development (Cambridge, England). PMID 32414936 DOI: 10.1242/Dev.183640  0.764
2020 Chen JK, Hom ME, Ondrus AE, Sakata-Kato T, Rack PG. Bicyclic imidazolium inhibitors of Gli transcription factor activity. Chemmedchem. PMID 32268014 DOI: 10.1002/Cmdc.202000169  0.757
2020 Crapster JA, Rack PG, Hellmann ZJ, Le AD, Adams CM, Leib RD, Elias JE, Perrino J, Behr B, Li Y, Lin J, Zeng H, Chen JK. HIPK4 is essential for murine spermiogenesis. Elife. 9. PMID 32163033 DOI: 10.7554/Elife.50209  0.319
2019 Pattanayak S, Vázquez-Maldonado LA, Deiters A, Chen JK. Combinatorial control of gene function with wavelength-selective caged morpholinos. Methods in Enzymology. 624: 69-88. PMID 31370936 DOI: 10.1016/Bs.Mie.2019.04.007  0.781
2018 Gutzman JH, Graeden E, Brachmann I, Yamazoe S, Chen JK, Sive H. Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Biology Open. PMID 30305282 DOI: 10.1242/Bio.034520  0.383
2018 Hwang S, Mruk K, Rahighi S, Raub AG, Chen CH, Dorn LE, Horikoshi N, Wakatsuki S, Chen JK, Mochly-Rosen D. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nature Communications. 9: 4045. PMID 30279493 DOI: 10.1038/S41467-018-06447-Z  0.737
2018 Breslow DK, Hoogendoorn S, Kopp AR, Morgens DW, Vu BK, Kennedy MC, Han K, Li A, Hess GT, Bassik MC, Chen JK, Nachury MV. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Nature Genetics. PMID 29459677 DOI: 10.1038/S41588-018-0054-7  0.366
2017 Cho U, Riordan DP, Ciepla P, Kocherlakota KS, Chen JK, Harbury PB. Ultrasensitive optical imaging with lanthanide lumiphores. Nature Chemical Biology. PMID 29106397 DOI: 10.1038/Nchembio.2513  0.758
2017 Crapster JA, Hudgins L, Chen JK, Gomez-Ospina N. A novel missense variant in the GLI3 zinc finger domain in a family with digital anomalies. American Journal of Medical Genetics. Part A. PMID 28884880 DOI: 10.1002/Ajmg.A.38415  0.37
2017 Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, ... ... Chen JK, et al. Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action. Elife. 6. PMID 28524820 DOI: 10.7554/Elife.25174  0.77
2017 Kowalik L, Chen JK. Illuminating developmental biology through photochemistry. Nature Chemical Biology. 13: 587-598. PMID 28514427 DOI: 10.1038/Nchembio.2369  0.699
2017 Wong WT, Matrone G, Tian X, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP. Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. Elife. 6. PMID 28323620 DOI: 10.7554/Elife.23588  0.343
2017 Ouyang X, Panetta NJ, Talbott MD, Payumo AY, Halluin C, Longaker MT, Chen JK. Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. Plos One. 12: e0171898. PMID 28207787 DOI: 10.1371/Journal.Pone.0171898  0.756
2016 Lee JJ, Rothenberg ME, Seeley ES, Zimdahl B, Kawano S, Lu WJ, Shin K, Sakata-Kato T, Chen JK, Diehn M, Clarke MF, Beachy PA. Control of inflammation by stromal Hedgehog pathway activation restrains colitis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27815529 DOI: 10.1073/Pnas.1616447113  0.775
2016 Schmitt AM, Garcia JT, Hung T, Flynn RA, Shen Y, Qu K, Payumo AY, Peres-da-Silva A, Broz DK, Baum R, Guo S, Chen JK, Attardi LD, Chang HY. An inducible long noncoding RNA amplifies DNA damage signaling. Nature Genetics. PMID 27668660 DOI: 10.1038/Ng.3673  0.744
2016 Payumo AY, McQuade LE, Walker WJ, Yamazoe S, Chen JK. Tbx16 regulates hox gene activation in mesodermal progenitor cells. Nature Chemical Biology. PMID 27376691 DOI: 10.1038/Nchembio.2124  0.767
2016 Chen JK. I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs. Natural Product Reports. PMID 26787175 DOI: 10.1039/C5Np00153F  0.347
2015 Shen CR, Juang HH, Chen HS, Yang CJ, Wu CJ, Lee MH, Hwang YS, Kuo ML, Chen YS, Chen JK, Liu CL. The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma. International Journal of Molecular Sciences. 16: 27371-27377. PMID 26580611 DOI: 10.3390/ijms161126033  0.461
2015 See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury MV, Kapoor TM, Chen JK. Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity. Acs Chemical Biology. PMID 26555042 DOI: 10.1021/Acschembio.5B00895  0.599
2015 Mruk K, Chen JK. Thinking big with small molecules. The Journal of Cell Biology. 209: 7-9. PMID 25869661 DOI: 10.1083/Jcb.201501084  0.758
2015 Payumo AY, Walker WJ, McQuade LE, Yamazoe S, Chen JK. Optochemical Dissection of T-box Gene-Dependent Medial Floor Plate Development. Acs Chemical Biology. 10: 1466-75. PMID 25781211 DOI: 10.1021/Cb5010178  0.761
2014 Yamazoe S, Liu Q, McQuade LE, Deiters A, Chen JK. Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides. Angewandte Chemie (International Ed. in English). 53: 10114-8. PMID 25130695 DOI: 10.1002/Anie.201405355  0.326
2014 Yamazoe S, McQuade LE, Chen JK. Nitroreductase-activatable morpholino oligonucleotides for in vivo gene silencing. Acs Chemical Biology. 9: 1985-90. PMID 25069083 DOI: 10.1021/Cb500429U  0.369
2014 Mich JK, Payumo AY, Rack PG, Chen JK. In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter. Plos One. 9: e103661. PMID 25068273 DOI: 10.1371/Journal.Pone.0103661  0.798
2014 Rack PG, Ni J, Payumo AY, Nguyen V, Crapster JA, Hovestadt V, Kool M, Jones DT, Mich JK, Firestone AJ, Pfister SM, Cho YJ, Chen JK. Arhgap36-dependent activation of Gli transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 111: 11061-6. PMID 25024229 DOI: 10.1073/Pnas.1322362111  0.777
2014 Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, et al. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3091-100. PMID 25024225 DOI: 10.1073/Pnas.1411679111  0.619
2014 Sikirzhytski V, Magidson V, Steinman JB, He J, Le Berre M, Tikhonenko I, Ault JG, McEwen BF, Chen JK, Sui H, Piel M, Kapoor TM, Khodjakov A. Direct kinetochore-spindle pole connections are not required for chromosome segregation. The Journal of Cell Biology. 206: 231-43. PMID 25023516 DOI: 10.1083/Jcb.201401090  0.495
2014 Bonger KM, Rakhit R, Payumo AY, Chen JK, Wandless TJ. General method for regulating protein stability with light. Acs Chemical Biology. 9: 111-5. PMID 24180414 DOI: 10.1021/Cb400755B  0.772
2013 Chen JK, Du Bois J, Glenn J, Herschlag D, Khosla C. The Stanford Institute for Chemical Biology. Acs Chemical Biology. 8: 1860-1. PMID 24053754 DOI: 10.1021/Cb400641U  0.548
2013 Moore JC, Sheppard-Tindell S, Shestopalov IA, Yamazoe S, Chen JK, Lawson ND. Post-transcriptional mechanisms contribute to Etv2 repression during vascular development. Developmental Biology. 384: 128-40. PMID 24036310 DOI: 10.1016/J.Ydbio.2013.08.028  0.331
2013 Yi J, Wu X, Chung AH, Chen JK, Kapoor TM, Hammer JA. Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage. The Journal of Cell Biology. 202: 779-92. PMID 23979719 DOI: 10.1083/Jcb.201301004  0.561
2013 Liu X, Kapoor TM, Chen JK, Huse M. Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II. Proceedings of the National Academy of Sciences of the United States of America. 110: 11976-81. PMID 23818610 DOI: 10.1073/Pnas.1306180110  0.562
2013 Cho YS, Jung HJ, Seok SH, Payumo AY, Chen JK, Kwon HJ. Functional inhibition of UQCRB suppresses angiogenesis in zebrafish. Biochemical and Biophysical Research Communications. 433: 396-400. PMID 23454382 DOI: 10.1016/J.Bbrc.2013.02.082  0.738
2013 Schmitt A, Hung T, Flynn R, Payumo A, Peres-da-Silva A, Kenzelmann Broz D, Attardi L, Chen J, Chang H. Regulation of the DNA Damage Response by an Inducible Long Noncoding RNA International Journal of Radiation Oncology*Biology*Physics. 87: S19. DOI: 10.1016/J.Ijrobp.2013.06.055  0.716
2012 Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. Plos One. 7: e41831. PMID 22848625 DOI: 10.1371/Journal.Pone.0041831  0.303
2012 Yamazoe S, Shestopalov IA, Provost E, Leach SD, Chen JK. Cyclic caged morpholinos: conformationally gated probes of embryonic gene function. Angewandte Chemie (International Ed. in English). 51: 6908-11. PMID 22689470 DOI: 10.1002/Anie.201201690  0.345
2012 Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 484: 125-9. PMID 22425997 DOI: 10.1038/Nature10936  0.767
2012 Shestopalov IA, Pitt CL, Chen JK. Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development. Nature Chemical Biology. 8: 270-6. PMID 22286130 DOI: 10.1038/Nchembio.772  0.388
2012 Chen JK. Abstract IA19: Small-molecule modulators of the Hedgehog signaling pathway Cancer Research. 72. DOI: 10.1158/1538-7445.Csb12-Ia19  0.435
2011 England S, Batista MF, Mich JK, Chen JK, Lewis KE. Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons. Development (Cambridge, England). 138: 5121-34. PMID 22069186 DOI: 10.1242/Dev.066159  0.734
2011 Mich JK, Chen JK. Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish. Development (Cambridge, England). 138: 5113-9. PMID 22069185 DOI: 10.1242/Dev.066225  0.751
2011 Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP. Neuropilins are positive regulators of Hedgehog signal transduction. Genes & Development. 25: 2333-46. PMID 22051878 DOI: 10.1101/Gad.173054.111  0.412
2011 Heine VM, Griveau A, Chapin C, Ballard PL, Chen JK, Rowitch DH. A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Science Translational Medicine. 3: 105ra104. PMID 22013124 DOI: 10.1126/Scitranslmed.3002731  0.309
2011 Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, ... ... Chen JK, et al. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nature Medicine. 17: 1504-8. PMID 21983857 DOI: 10.1038/Nm.2473  0.33
2011 Shestopalov IA, Chen JK. Spatiotemporal control of embryonic gene expression using caged morpholinos. Methods in Cell Biology. 104: 151-72. PMID 21924162 DOI: 10.1016/B978-0-12-374814-0.00009-4  0.354
2011 Clanton JA, Shestopalov I, Chen JK, Gamse JT. Lineage labeling of zebrafish cells with laser uncagable fluorescein dextran. Journal of Visualized Experiments : Jove. PMID 21559005 DOI: 10.3791/2672  0.306
2011 Sakata T, Chen JK. Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways. Chemical Society Reviews. 40: 4318-31. PMID 21505654 DOI: 10.1039/C1Cs15019G  0.375
2011 Spencer VA, Costes S, Inman JL, Xu R, Chen J, Hendzel MJ, Bissell MJ. Depletion of nuclear actin is a key mediator of quiescence in epithelial cells. Journal of Cell Science. 124: 123-32. PMID 21172822 DOI: 10.1242/Jcs.073197  0.342
2011 Spencer VA, Costes S, Inman JL, Xu R, Chen J, Hendzel MJ, Bissell MJ. Depletion of nuclear actin is a key mediator of quiescence in epithelial cells Development. 138. DOI: 10.1242/Dev.063131  0.305
2010 Ouyang X, Chen JK. Synthetic strategies for studying embryonic development. Chemistry & Biology. 17: 590-606. PMID 20609409 DOI: 10.1016/J.Chembiol.2010.04.013  0.328
2010 Shestopalov IA, Chen JK. Oligonucleotide-based tools for studying zebrafish development. Zebrafish. 7: 31-40. PMID 20392138 DOI: 10.1089/Zeb.2010.0650  0.32
2010 Firestone AJ, Chen JK. Controlling destiny through chemistry: small-molecule regulators of cell fate. Acs Chemical Biology. 5: 15-34. PMID 20000447 DOI: 10.1021/Cb900249Y  0.732
2010 CHEN JK, SCHREIBER SL. ChemInform Abstract: Combinatorial Synthesis and Multi-Dimensional NMR Spectroscopy - An Understanding of Protein-Ligand Interactions Cheminform. 26: no-no. DOI: 10.1002/chin.199535318  0.333
2009 Ouyang X, Shestopalov IA, Sinha S, Zheng G, Pitt CL, Li WH, Olson AJ, Chen JK. Versatile synthesis and rational design of caged morpholinos. Journal of the American Chemical Society. 131: 13255-69. PMID 19708646 DOI: 10.1021/Ja809933H  0.732
2009 Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences of the United States of America. 106: 14132-7. PMID 19666565 DOI: 10.1073/Pnas.0907134106  0.801
2009 Mich JK, Blaser H, Thomas NA, Firestone AJ, Yelon D, Raz E, Chen JK. Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental Biology. 328: 342-54. PMID 19389352 DOI: 10.1016/J.Ydbio.2009.01.036  0.789
2009 Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Li S, Jiang J, Chen JK, Yang Z, Lin S. Converse conformational control of smoothened activity by structurally related small molecules. The Journal of Biological Chemistry. 284: 20876-84. PMID 19366682 DOI: 10.1074/Jbc.M807648200  0.405
2009 Cupido T, Rack PG, Firestone AJ, Hyman JM, Han K, Sinha S, Ocasio CA, Chen JK. The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angewandte Chemie (International Ed. in English). 48: 2321-4. PMID 19222062 DOI: 10.1002/Anie.200805666  0.798
2009 Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nature Chemical Biology. 5: 154-6. PMID 19151731 DOI: 10.1038/Nchembio.142  0.732
2008 Chen JK, Hurlstone AF. Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics. Zebrafish. 5: 193-195. PMID 20798783 DOI: 10.1089/Zeb.2008.0543  0.353
2008 Low WC, Wang C, Pan Y, Huang XY, Chen JK, Wang B. The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Developmental Biology. 321: 188-96. PMID 18590719 DOI: 10.1016/J.Ydbio.2008.06.014  0.392
2008 Shestopalov IA, Chen JK. Chemical technologies for probing embryonic development. Chemical Society Reviews. 37: 1294-307. PMID 18568156 DOI: 10.1039/B703023C  0.333
2008 Chen JK. Fish 'n clicks. Nature Chemical Biology. 4: 391-2. PMID 18560429 DOI: 10.1038/Nchembio0708-391  0.315
2008 Esengil H, Chen JK. Gene regulation technologies in zebrafish. Molecular Biosystems. 4: 300-8. PMID 18354783 DOI: 10.1039/B718447F  0.312
2008 Panetta NJ, Ouyang S, Quarto N, Chen JK, Longaker MT. Zebrafish maintain regenerative capacity with age Journal of the American College of Surgeons. 207. DOI: 10.1016/J.Jamcollsurg.2008.06.161  0.754
2007 Shestopalov IA, Sinha S, Chen JK. Light-controlled gene silencing in zebrafish embryos. Nature Chemical Biology. 3: 650-1. PMID 17717538 DOI: 10.1038/Nchembio.2007.30  0.736
2007 Esengil H, Chang V, Mich JK, Chen JK. Small-molecule regulation of zebrafish gene expression. Nature Chemical Biology. 3: 154-5. PMID 17237798 DOI: 10.1038/Nchembio858  0.753
2006 Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Molecular and Cellular Biology. 26: 7550-60. PMID 16908539 DOI: 10.1128/Mcb.00546-06  0.378
2006 Sinha S, Chen JK. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nature Chemical Biology. 2: 29-30. PMID 16408088 DOI: 10.1038/Nchembio753  0.747
2004 Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (New York, N.Y.). 306: 2257-60. PMID 15618519 DOI: 10.1126/Science.1104135  0.588
2002 Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes & Development. 16: 2743-8. PMID 12414725 DOI: 10.1101/Gad.1025302  0.625
2002 Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of Smoothened activity. Proceedings of the National Academy of Sciences of the United States of America. 99: 14071-6. PMID 12391318 DOI: 10.1073/Pnas.182542899  0.647
2002 Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (New York, N.Y.). 297: 1559-61. PMID 12202832 DOI: 10.1126/Science.1073733  0.59
2000 Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 406: 1005-9. PMID 10984056 DOI: 10.1038/35023008  0.591
1999 Chen JK, Lane WS, Schreiber SL. The identification of myriocin-binding proteins. Chemistry & Biology. 6: 221-35. PMID 10099133 DOI: 10.1016/S1074-5521(99)80038-6  0.473
1996 Choi J, Chen J, Schreiber SL, Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (New York, N.Y.). 273: 239-42. PMID 8662507 DOI: 10.1126/Science.273.5272.239  0.387
1996 Combs AP, Kapoor TM, Feng S, Chen JK, Daudé-Snow LF, Schreiber SL. Protein structure-based combinatorial chemistry: Discovery of non-peptide binding elements to Src SH3 domain Journal of the American Chemical Society. 118: 287-288. DOI: 10.1021/Ja953750V  0.618
1995 Chen JK, Schreiber SL. Combinatorial Synthesis and Multidimensional NMR Spectroscopy: An Approach to Understanding Protein–Ligand Interactions Angewandte Chemie International Edition in English. 34: 953-969. DOI: 10.1002/Anie.199509531  0.481
1995 Chen JK, Schreiber SL. Kombinatorische Synthese und mehrdimensionale NMR-Spektroskopie: ein Beitrag zum Verständnis von Protein-Ligand-Wechselwirkungen Angewandte Chemie. 107: 1041-1058. DOI: 10.1002/Ange.19951070904  0.401
1994 Feng S, Chen JK, Yu H, Simon JA, Schreiber SL. Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science (New York, N.Y.). 266: 1241-7. PMID 7526465 DOI: 10.1126/Science.7526465  0.407
1994 Yu H, Chen JK, Feng S, Dalgarno DC, Brauer AW, Schreiber SL. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell. 76: 933-45. PMID 7510218 DOI: 10.1016/0092-8674(94)90367-0  0.42
1994 Gomez FA, Chen JK, Tanaka A, Schreiber SL, Whitesides GM. Affinity Capillary Electrophoresis: Insights into the Binding of SH3 Domains by Peptides Derived from an SH3-Binding Protein The Journal of Organic Chemistry. 59: 2885-2886. DOI: 10.1021/Jo00089A038  0.491
1994 Chen JK, Schreiber SL. SH3 domain-mediated dimerization of an n-terminal fragment of the phosphatidylinositol 3-kinase p85 subunit Bioorganic & Medicinal Chemistry Letters. 4: 1755-1760. DOI: 10.1016/S0960-894X(00)80375-3  0.412
1993 Chu YH, Chen JK, Whitesides GM. Affinity electrophoresis in multisectional polyacrylamide slab gels is a useful and convenient technique for measuring binding constants of aryl sulfonamides to bovine carbonic anhydrase B. Analytical Chemistry. 65: 1314-22. PMID 8517543 DOI: 10.1021/Ac00058A004  0.369
1993 Chen JK, Lane WS, Brauer AW, Tanaka A, Schreiber SL. Biased combinatorial libraries: novel ligands for the SH3 domain of phosphatidylinositol 3-kinase Journal of the American Chemical Society. 115: 12591-12592. DOI: 10.1021/Ja00079A051  0.408
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