Gal Bitan - Publications

Affiliations: 
Neurology University of California, Los Angeles, Los Angeles, CA 
Area:
Alzheimer's disease, Parkinson's disease, Drug development
Website:
http://dgsom.healthsciences.ucla.edu/research/institution/personnel?personnel%5fid=74903

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, ... ... Bitan G, et al. Major differences between the self-assembly and seeding behavior of heparin-induced- and in-vitro-phosphorylated tau and their modulation by potential inhibitors. Acs Chemical Biology. PMID 31046227 DOI: 10.1021/acschembio.9b00325  0.6
2019 Yan Z, Dutta S, Liu Z, Yu X, Mesgarzadeh N, Ji F, Bitan G, Xie YH. A Label-free Platform for Identification of Exosomes from Different Sources. Acs Sensors. PMID 30644736 DOI: 10.1021/acssensors.8b01564  0.44
2019 Malik R, Meng H, Wongkongkathep P, Corrales CI, Sepanj N, Atlasi RS, Klärner FG, Schrader T, Spencer MJ, Loo JA, Wiedau M, Bitan G. The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. The Journal of Biological Chemistry. PMID 30602569 DOI: 10.1074/jbc.RA118.005940  0.6
2018 Nshanian M, Lantz C, Wongkongkathep P, Schrader T, Klärner FG, Blümke A, Despres C, Ehrmann M, Smet-Nocca C, Bitan G, Loo JA. Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator. Journal of the American Society For Mass Spectrometry. PMID 30062477 DOI: 10.1007/s13361-018-2027-6  0.6
2018 Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. Preparation of Pure Populations of Amyloid β-Protein Oligomers of Defined Size. Methods in Molecular Biology (Clifton, N.J.). 1779: 3-12. PMID 29886523 DOI: 10.1007/978-1-4939-7816-8_1  0.84
2018 Malik R, Di J, Nair G, Attar A, Taylor K, Teng E, Klärner FG, Schrader T, Bitan G. Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins. Methods in Molecular Biology (Clifton, N.J.). 1777: 369-386. PMID 29744849 DOI: 10.1007/978-1-4939-7811-3_24  1
2018 Röcker AE, Müller JA, Dietzel E, Harms M, Krüger F, Heid C, Sowislok A, Riber CF, Kupke A, Lippold S, von Einem J, Beer J, Knöll B, Becker S, Schmidt-Chanasit J, ... ... Bitan G, et al. The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Research. 152: 26-35. PMID 29428508 DOI: 10.1016/j.antiviral.2018.02.003  0.6
2017 Xu N, Bitan G, Schrader T, Klärner FG, Osinska H, Robbins J. Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer. Journal of the American Heart Association. 6. PMID 28862927 DOI: 10.1161/JAHA.117.006182  0.6
2017 Richter F, Subramaniam SR, Magen I, Lee P, Hayes J, Attar A, Zhu C, Franich NR, Bove N, De La Rosa K, Kwong J, Klärner FG, Schrader T, Chesselet MF, Bitan G. A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28585223 DOI: 10.1007/s13311-017-0544-9  1
2017 Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, et al. Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. Journal of the American Chemical Society. PMID 28406616 DOI: 10.1021/jacs.6b11039  0.64
2016 Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes. Analytical Biochemistry. PMID 27810329 DOI: 10.1016/j.ab.2016.10.026  0.84
2016 Schrader T, Bitan G, Klärner FG. Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation. Chemical Communications (Cambridge, England). PMID 27546596 DOI: 10.1039/c6cc04640a  0.6
2016 Li H, Rahimi F, Bitan G. Modulation of amyloid β-protein (Aβ) assembly by homologous C-terminal fragments as a strategy for inhibiting Aβ toxicity. Acs Chemical Neuroscience. PMID 27322435 DOI: 10.1021/acschemneuro.6b00154  1
2016 Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. Neurotoxicity of the Parkinson's Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environmental Health Perspectives. PMID 27301718 DOI: 10.1289/EHP141  0.6
2016 Fogerson SM, van Brummen AJ, Busch DJ, Allen SR, Roychaudhuri R, Banks SM, Klärner FG, Schrader T, Bitan G, Morgan JR. Reducing synuclein accumulation improves neuronal survival after spinal cord injury. Experimental Neurology. PMID 26854933 DOI: 10.1016/j.expneurol.2016.02.004  1
2015 Zheng X, Wu C, Liu D, Li H, Bitan G, Shea JE, Bowers MT. Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity? The Journal of Physical Chemistry. B. PMID 26439281 DOI: 10.1021/acs.jpcb.5b08177  1
2015 Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB. Role of species-specific primary structure differences in Aβ42 assembly and neurotoxicity. Acs Chemical Neuroscience. PMID 26421877 DOI: 10.1021/acschemneuro.5b00180  1
2015 Malishev R, Nandi S, Kolusheva S, Levi-Kalisman Y, Klärner FG, Schrader T, Bitan G, Jelinek R. Toxicity Inhibitors Protect Lipid Membranes from Disruption by Aβ42. Acs Chemical Neuroscience. PMID 26317327 DOI: 10.1021/acschemneuro.5b00200  1
2015 Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Bitan G, et al. A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 4. PMID 26284498 DOI: 10.7554/eLife.05397  0.6
2015 Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D. The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. Biochemistry. 54: 3729-38. PMID 26030124 DOI: 10.1021/bi501092p  1
2015 Lopes DH, Attar A, Nair G, Hayden EY, Du Z, McDaniel K, Dutt S, Bravo-Rodriguez K, Mittal S, Klärner FG, Wang C, Sanchez-Garcia E, Schrader T, Bitan G. Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism. Acs Chemical Biology. 10: 1555-69. PMID 25844890 DOI: 10.1021/acschembio.5b00146  1
2015 Zheng X, Liu D, Klärner FG, Schrader T, Bitan G, Bowers MT. Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03. The Journal of Physical Chemistry. B. 119: 4831-41. PMID 25751170 DOI: 10.1021/acs.jpcb.5b00692  1
2015 Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, Von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Bitan G, et al. A molecular tweezer antagonizes seminal amyloids and HIV infection Elife. 4. DOI: 10.7554/eLife.05397  1
2014 Aronovich D, Bitan G, Bartal G. Exact modeling of cylindrical metal-dielectric multilayers beyond the effective medium approximation. Optics Letters. 39: 6517-20. PMID 25490508 DOI: 10.1364/OL.39.006517  1
2014 Attar A, Chan WT, Klärner FG, Schrader T, Bitan G. Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity. Bmc Pharmacology & Toxicology. 15: 23. PMID 24735982 DOI: 10.1186/2050-6511-15-23  1
2014 Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ. Molecular basis for preventing α-synuclein aggregation by a molecular tweezer. The Journal of Biological Chemistry. 289: 10727-37. PMID 24567327 DOI: 10.1074/jbc.M113.524520  1
2014 Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR. Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 450-61. PMID 24459092 DOI: 10.1007/s13311-013-0256-8  1
2014 Attar A, Bitan G. Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models. Current Pharmaceutical Design. 20: 2469-83. PMID 23859557  1
2014 Rahimi F, Bitan G. Overview of fibrillar and oligomeric assemblies of amyloidogenic proteins Non-Fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. 2147483647: 1-36. DOI: 10.1007/978-94-007-2774-8_1  1
2014 Rahimi F, Bitan G. Preface Non-Fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. 2147483647: v-vi. DOI: 10.1007/978-94-007-2774-8  1
2013 Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G. A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease. Plos One. 8: e80355. PMID 24236177 DOI: 10.1371/journal.pone.0080355  1
2013 Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C. Tranilast binds to aβ monomers and promotes aβ fibrillation. Biochemistry. 52: 3995-4002. PMID 23679559 DOI: 10.1021/bi400426t  1
2013 Ripoli C, Piacentini R, Riccardi E, Leone L, Li Puma DD, Bitan G, Grassi C. Effects of different amyloid β-protein analogues on synaptic function. Neurobiology of Aging. 34: 1032-44. PMID 23046860 DOI: 10.1016/j.neurobiolaging.2012.06.027  1
2013 Attar A, Rahimi F, Bitan G. Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01 Translational Neuroscience. 4: 385-409. DOI: 10.2478/s13380-013-0137-y  1
2013 Attar A, Meral D, Urbanc B, Bitan G. Assembly of Amyloid β-Protein Variants Containing Familial Alzheimer's Disease-Linked Amino Acid Substitutions Bio-Nanoimaging: Protein Misfolding and Aggregation. 429-442. DOI: 10.1016/B978-0-12-394431-3.00038-9  1
2012 Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, ... ... Bitan G, et al. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain : a Journal of Neurology. 135: 3735-48. PMID 23183235 DOI: 10.1093/brain/aws289  1
2012 Sinha S, Lopes DH, Bitan G. A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity. Acs Chemical Neuroscience. 3: 473-81. PMID 22860216 DOI: 10.1021/cn3000247  1
2012 Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. Acs Chemical Neuroscience. 3: 451-8. PMID 22860214 DOI: 10.1021/cn200133x  1
2012 Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G. Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dementia and Geriatric Cognitive Disorders. 33: 219-25. PMID 22584618 DOI: 10.1159/000338546  1
2012 Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I. Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons. The Journal of Biological Chemistry. 287: 20555-64. PMID 22528492 DOI: 10.1074/jbc.M112.344036  1
2012 Rosensweig C, Ono K, Murakami K, Lowenstein DK, Bitan G, Teplow DB. Preparation of stable amyloid β-protein oligomers of defined assembly order. Methods in Molecular Biology (Clifton, N.J.). 849: 23-31. PMID 22528081 DOI: 10.1007/978-1-61779-551-0_3  1
2012 Lopes DH, Sinha S, Rosensweig C, Bitan G. Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins. Methods in Molecular Biology (Clifton, N.J.). 849: 11-21. PMID 22528080 DOI: 10.1007/978-1-61779-551-0_2  1
2012 Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS. Design of β-amyloid aggregation inhibitors from a predicted structural motif. Journal of Medicinal Chemistry. 55: 3002-10. PMID 22420626 DOI: 10.1021/jm201332p  1
2012 Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 9: 464-76. PMID 22373667 DOI: 10.1007/s13311-012-0105-1  1
2012 Liu T, Bitan G. Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms. Chemmedchem. 7: 359-74. PMID 22323134 DOI: 10.1002/cmdc.201100585  1
2012 Li H, Zemel R, Lopes DH, Monien BH, Bitan G. A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors. Chemmedchem. 7: 515-22. PMID 22307963 DOI: 10.1002/cmdc.201100584  1
2012 Gessel MM, Wu C, Li H, Bitan G, Shea JE, Bowers MT. Aβ(39-42) modulates Aβ oligomerization but not fibril formation. Biochemistry. 51: 108-17. PMID 22129303 DOI: 10.1021/bi201520b  1
2011 Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G. C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42. Journal of Medicinal Chemistry. 54: 8451-60. PMID 22087474 DOI: 10.1021/jm200982p  1
2011 Moskovitz J, Maiti P, Lopes DH, Oien DB, Attar A, Liu T, Mittal S, Hayes J, Bitan G. Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo. Biochemistry. 50: 10687-97. PMID 22059533 DOI: 10.1021/bi201426b  1
2011 Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, ... ... Bitan G, et al. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. Journal of the American Chemical Society. 133: 16958-69. PMID 21916458 DOI: 10.1021/ja206279b  1
2011 Urbanc B, Betnel M, Cruz L, Li H, Fradinger EA, Monien BH, Bitan G. Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study. Journal of Molecular Biology. 410: 316-28. PMID 21621545 DOI: 10.1016/j.jmb.2011.05.021  1
2011 Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T. Rational design of β-sheet ligands against Aβ42-induced toxicity. Journal of the American Chemical Society. 133: 4348-58. PMID 21381732 DOI: 10.1021/ja107675n  1
2011 Maiti P, Piacentini R, Ripoli C, Grassi C, Bitan G. Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone. The Biochemical Journal. 433: 323-32. PMID 21044048 DOI: 10.1042/BJ20101391  1
2010 Rahimi F, Bitan G. Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease. Journal of Visualized Experiments : Jove. PMID 20616783 DOI: 10.3791/1955  1
2010 Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry. 49: 6358-64. PMID 20568734 DOI: 10.1021/bi100773g  1
2010 Maiti P, Lomakin A, Benedek GB, Bitan G. Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity. Journal of Neurochemistry. 113: 1252-62. PMID 20345758 DOI: 10.1111/j.1471-4159.2010.06692.x  1
2010 Urbanc B, Betnel M, Cruz L, Bitan G, Teplow DB. Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study. Journal of the American Chemical Society. 132: 4266-80. PMID 20218566 DOI: 10.1021/ja9096303  1
2010 Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G. Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry. 49: 1259-67. PMID 20050679 DOI: 10.1021/bi902075h  1
2009 Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT. Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nature Chemistry. 1: 326-31. PMID 20703363 DOI: 10.1038/nchem.247  1
2009 Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G. RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. Plos One. 4: e7694. PMID 19901993 DOI: 10.1371/journal.pone.0007694  1
2009 Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB. Amino acid position-specific contributions to amyloid beta-protein oligomerization. The Journal of Biological Chemistry. 284: 23580-91. PMID 19567875 DOI: 10.1074/jbc.M109.038133  1
2009 Wu C, Murray MM, Bernstein SL, Condron MM, Bitan G, Shea JE, Bowers MT. The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. Journal of Molecular Biology. 387: 492-501. PMID 19356595 DOI: 10.1016/j.jmb.2009.01.029  1
2009 Rahimi F, Maiti P, Bitan G. Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. Journal of Visualized Experiments : Jove. PMID 19229175 DOI: 10.3791/1071  1
2008 Condron MM, Monien BH, Bitan G. Synthesis and Purification of Highly Hydrophobic Peptides Derived from the C-Terminus of Amyloid β-Protein. The Open Biotechnology Journal. 2: 87-93. PMID 19898686 DOI: 10.2174/1874070700802010087  0.76
2008 Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 14175-80. PMID 18779585 DOI: 10.1073/pnas.0807163105  1
2008 Rahimi F, Shanmugam A, Bitan G. Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Current Alzheimer Research. 5: 319-41. PMID 18537546 DOI: 10.2174/156720508784533358  1
2008 Feigenbaum E, Afriat G, Bitan G, Orenstein M. "Effective Index Method"- Is it valid for nano-circuitry based on Plasmonic gaps? Conference On Quantum Electronics and Laser Science (Qels) - Technical Digest Series. DOI: 10.1109/QELS.2008.4553018  1
2008 Lazo ND, Maji SK, Fradinger EA, Bitan G, Teplow DB. The Amyloid β Protein Amyloid Proteins: the Beta Sheet Conformation and Disease. 2: 384-491. DOI: 10.1002/9783527619344.ch17  1
2007 Yun S, Urbanc B, Cruz L, Bitan G, Teplow DB, Stanley HE. Role of electrostatic interactions in amyloid beta-protein (A beta) oligomer formation: a discrete molecular dynamics study. Biophysical Journal. 92: 4064-77. PMID 17307823 DOI: 10.1529/biophysj.106.097766  1
2007 Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA. Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiology of Aging. 28: 813-23. PMID 16725229 DOI: 10.1016/j.neurobiolaging.2006.04.007  1
2006 Bitan G. Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins. Methods in Enzymology. 413: 217-36. PMID 17046399 DOI: 10.1016/S0076-6879(06)13012-8  1
2006 Monien BH, Apostolova LG, Bitan G. Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there? Expert Review of Neurotherapeutics. 6: 1293-306. PMID 17009917 DOI: 10.1586/14737175.6.9.1293  1
2006 Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea JE, Urbanc B, Cruz L, Borreguero J, Stanley HE. Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Accounts of Chemical Research. 39: 635-45. PMID 16981680 DOI: 10.1021/ar050063s  1
2006 Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, Shea JE. Amyloid beta-protein monomer structure: a computational and experimental study. Protein Science : a Publication of the Protein Society. 15: 420-8. PMID 16501222 DOI: 10.1110/ps.051762406  1
2005 Fradinger EA, Bitan G. En route to early diagnosis of Alzheimer's disease--are we there yet? Trends in Biotechnology. 23: 531-3. PMID 16165236 DOI: 10.1016/j.tibtech.2005.09.002  1
2005 Bitan G, Fradinger EA, Spring SM, Teplow DB. Neurotoxic protein oligomers--what you see is not always what you get. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 12: 88-95. PMID 16011984 DOI: 10.1080/13506120500106958  1
2005 Vollers SS, Teplow DB, Bitan G. Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods in Molecular Biology (Clifton, N.J.). 299: 11-8. PMID 15980592  1
2005 Bitan G, Teplow DB. Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods in Molecular Biology (Clifton, N.J.). 299: 3-9. PMID 15980591  1
2005 Bernstein SL, Wyttenbach T, Baumketner A, Shea JE, Bitan G, Teplow DB, Bowers MT. Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. Journal of the American Chemical Society. 127: 2075-84. PMID 15713083 DOI: 10.1021/ja044531p  1
2004 Urbanc B, Cruz L, Yun S, Buldyrev SV, Bitan G, Teplow DB, Stanley HE. In silico study of amyloid beta-protein folding and oligomerization. Proceedings of the National Academy of Sciences of the United States of America. 101: 17345-50. PMID 15583128 DOI: 10.1073/pnas.0408153101  1
2004 Bitan G, Teplow DB. Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Accounts of Chemical Research. 37: 357-64. PMID 15196045 DOI: 10.1021/ar000214l  1
2003 Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, Teplow DB. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. Journal of the American Chemical Society. 125: 15359-65. PMID 14664580 DOI: 10.1021/ja0349296  1
2003 Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of Clinical Investigation. 112: 415-22. PMID 12897209 DOI: 10.1172/JCI18104  1
2003 Bitan G, Vollers SS, Teplow DB. Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. The Journal of Biological Chemistry. 278: 34882-9. PMID 12840029 DOI: 10.1074/jbc.M300825200  1
2003 Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB. Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proceedings of the National Academy of Sciences of the United States of America. 100: 330-5. PMID 12506200 DOI: 10.1073/pnas.222681699  1
2002 Sun B, Fan W, Balciunas A, Cooper JK, Bitan G, Steavenson S, Denis PE, Young Y, Adler B, Daugherty L, Manoukian R, Elliott G, Shen W, Talvenheimo J, Teplow DB, et al. Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiology of Disease. 11: 111-22. PMID 12460551 DOI: 10.1006/nbdi.2002.0539  1
2002 Kirkitadze MD, Bitan G, Teplow DB. Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. Journal of Neuroscience Research. 69: 567-77. PMID 12210822 DOI: 10.1002/jnr.10328  1
2001 Scheibler L, Mierke DF, Bitan G, Rosenblatt M, Chorev M. Identification of a contact domain between echistatin and the integrin alpha(v)beta(3) by photoaffinity cross-linking. Biochemistry. 40: 15117-26. PMID 11735394 DOI: 10.1021/bi0109156  1
2001 Bitan G, Lomakin A, Teplow DB. Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins. The Journal of Biological Chemistry. 276: 35176-84. PMID 11441003 DOI: 10.1074/jbc.M102223200  1
2000 Bitan G, Scheibler L, Mierke DF, Rosenblatt M, Chorev M. Ligand-integrin alpha v beta 3 interaction determined by photoaffinity cross-linking: a challenge to the prevailing model. Biochemistry. 39: 11014-23. PMID 10998238 DOI: 10.1021/bi000877a  1
2000 Bitan G, Scheibler L, Teng H, Rosenblatt M, Chorev M. Design and evaluation of benzophenone-containing conformationally constrained ligands as tools for photoaffinity scanning of the integrin alphaVbeta3-ligand bimolecular interaction. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 181-94. PMID 10727100 DOI: 10.1034/j.1399-3011.2000.00155.x  1
2000 Behar V, Bisello A, Bitan G, Rosenblatt M, Chorev M. Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor. The Journal of Biological Chemistry. 275: 9-17. PMID 10617579 DOI: 10.1074/jbc.275.1.9  1
1999 Bitan G, Scheibler L, Greenberg Z, Rosenblatt M, Chorev M. Mapping the integrin alpha V beta 3-ligand interface by photoaffinity cross-linking. Biochemistry. 38: 3414-20. PMID 10079087 DOI: 10.1021/bi981946c  1
1998 Kasher R, Bitan G, Halloun C, Gilon C. Synthesis of a bicyclic BPTI mimetic containing 4-thioproline replacing Cys38 Letters in Peptide Science. 5: 101-103.  1
1997 Muller D, Zeltser I, Bitan G, Gilon C. Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N(alpha)-(omega-Aminoalkyl)amino Acids and N(alpha)-(omega-Carboxyalkyl)amino Acids. The Journal of Organic Chemistry. 62: 411-416. PMID 11671417  0.84
1997 Bitan G, Sukhotinsky I, Mashriki Y, Hanani M, Selinger Z, Gilon C. Synthesis and biological activity of novel backbone-bicyclic substance-P analogs containing lactam and disulfide bridges. The Journal of Peptide Research : Official Journal of the American Peptide Society. 49: 421-6. PMID 9211223  1
1997 Muller D, Zeltser I, Bitan G, Gilon C. Building units for N-backbone cyclic peptides. 3. Synthesis of protected N(α)-(ω-aminoalkyl)amino acids and N(α)-(ω-carboxyalkyl)amino acids Journal of Organic Chemistry. 62: 411-416. DOI: 10.1021/jo961580e  1
1997 Bitan G, Muller D, Kasher R, Gluhov EV, Gilon C. Building units for N-backbone cyclic peptides. Part 4. Synthesis of protected Nα-functionalized alkyl amino acids by reductive alkylation of natural amino acids Journal of the Chemical Society - Perkin Transactions 1. 1501-1510.  1
1996 Bitan G, Zeltser I, Byk G, Halle D, Mashriki Y, Gluhov EV, Sukhotinsky I, Hanani M, Selinger Z, Gilon C. Backbone cyclization of the C-terminal part of substance P. Part 1: The important role of the sulphur in position 11. Journal of Peptide Science : An Official Publication of the European Peptide Society. 2: 261-9. PMID 9231334 DOI: 10.1002/psc.76  1
1996 Behrens S, Mathä B, Bitan G, Gilon C, Kessler H. Structure-activity relationship of the ring portion in backbone-cyclic C-terminal hexapeptide analogs of substance P. NMR and molecular dynamics. International Journal of Peptide and Protein Research. 48: 569-79. PMID 8985790  1
1996 Byk G, Halle D, Zeltser I, Bitan G, Selinger Z, Gilon C. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. Journal of Medicinal Chemistry. 39: 3174-8. PMID 8759639 DOI: 10.1021/jm960154i  1
1995 Bitan G, Behrens S, Mathä B, Mashriki Y, Hanani M, Kessler H, Gilon C. New backbone cyclic substance P analogs Letters in Peptide Science. 2: 121-124. DOI: 10.1007/BF00119137  1
1991 Blum J, Bitan G, Marx S, Vollhardt KPC. Transfer hydrogenation of diarylacetylenes by polymethylhydrosiloxane in the presence of the RhCl3-Aliquat 336 catalyst Journal of Molecular Catalysis. 66: 313-319. DOI: 10.1016/0304-5102(91)80023-V  1
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