Philip W. Landfield - Publications

Affiliations: 
Molecular and Biomedical Pharmacology University of Kentucky, Lexington, KY 

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Gant JC, Kadish I, Chen KC, Thibault O, Blalock EM, Porter NM, Landfield PW. Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear. Journal of Alzheimer's Disease : Jad. PMID 30412490 DOI: 10.3233/JAD-180618  1
2017 Gant JC, Blalock EM, Chen KC, Kadish I, Thibault O, Porter NM, Landfield PW. FK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+], rescues memory and restores genomic regulation in the hippocampus of aging rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29255009 DOI: 10.1523/JNEUROSCI.2234-17.2017  1
2015 Gant JC, Chen KC, Kadish I, Blalock EM, Thibault O, Porter NM, Landfield PW. Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10878-87. PMID 26224869 DOI: 10.1523/JNEUROSCI.1248-15.2015  1
2014 Latimer CS, Brewer LD, Searcy JL, Chen KC, Popovi? J, Kraner SD, Thibault O, Blalock EM, Landfield PW, Porter NM. Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats. Proceedings of the National Academy of Sciences of the United States of America. 111: E4359-66. PMID 25267625 DOI: 10.1073/pnas.1404477111  1
2014 Gant JC, Blalock EM, Chen KC, Kadish I, Porter NM, Norris CM, Thibault O, Landfield PW. FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? European Journal of Pharmacology. 739: 74-82. PMID 24291098 DOI: 10.1016/j.ejphar.2013.10.070  1
2013 Thibault O, Anderson KL, DeMoll C, Brewer LD, Landfield PW, Porter NM. Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. European Journal of Pharmacology. 719: 34-43. PMID 23872402 DOI: 10.1016/j.ejphar.2013.07.024  1
2013 Chen KC, Blalock EM, Curran-Rauhut MA, Kadish I, Blalock SJ, Brewer L, Porter NM, Landfield PW. Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging. Endocrinology. 154: 2807-20. PMID 23736296 DOI: 10.1210/en.2013-1139  1
2013 Pancani T, Anderson KL, Brewer LD, Kadish I, DeMoll C, Landfield PW, Blalock EM, Porter NM, Thibault O. Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats. Neurobiology of Aging. 34: 1977-87. PMID 23545425 DOI: 10.1016/j.neurobiolaging.2013.02.019  1
2012 Craft S, Foster TC, Landfield PW, Maier SF, Resnick SM, Yaffe K. Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 754-9. PMID 22570133 DOI: 10.1093/gerona/gls112  1
2012 Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O. Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 30: 943-61. PMID 22495349 DOI: 10.3233/JAD-2012-111661  1
2012 Thibault O, Pancani T, Landfield PW, Norris CM. Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease. Biochimica Et Biophysica Acta. 1822: 546-9. PMID 22265986 DOI: 10.1016/j.bbadis.2012.01.004  1
2011 Latimer CS, Searcy JL, Bridges MT, Brewer LD, Popovi? J, Blalock EM, Landfield PW, Thibault O, Porter NM. Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. Plos One. 6: e26812. PMID 22046366 DOI: 10.1371/journal.pone.0026812  1
2011 Blalock EM, Buechel HM, Popovic J, Geddes JW, Landfield PW. Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease. Journal of Chemical Neuroanatomy. 42: 118-26. PMID 21756998 DOI: 10.1016/j.jchemneu.2011.06.007  1
2011 Gant JC, Chen KC, Norris CM, Kadish I, Thibault O, Blalock EM, Porter NM, Landfield PW. Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1693-703. PMID 21289178 DOI: 10.1523/JNEUROSCI.4805-10.2011  1
2010 Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW. Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6058-71. PMID 20427664 DOI: 10.1523/JNEUROSCI.3956-09.2010  1
2010 Norris CM, Blalock EM, Chen KC, Porter NM, Thibault O, Kraner SD, Landfield PW. Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging. Neurobiology of Aging. 31: 328-38. PMID 18471936 DOI: 10.1016/j.neurobiolaging.2008.03.026  1
2009 Brewer LD, Dowling AL, Curran-Rauhut MA, Landfield PW, Porter NM, Blalock EM. Estradiol reverses a calcium-related biomarker of brain aging in female rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6058-67. PMID 19439583 DOI: 10.1523/JNEUROSCI.5253-08.2009  1
2009 Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, Landfield PW. Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1805-16. PMID 19211887 DOI: 10.1523/JNEUROSCI.4599-08.2009  1
2007 Thibault O, Gant JC, Landfield PW. Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell. 6: 307-17. PMID 17465978 DOI: 10.1111/j.1474-9726.2007.00295.x  1
2007 Brewer LD, Thibault O, Staton J, Thibault V, Rogers JT, Garcia-Ramos G, Kraner S, Landfield PW, Porter NM. Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels. Brain Research. 1151: 20-31. PMID 17433272 DOI: 10.1016/j.brainres.2007.03.020  1
2007 Landfield PW, Blalock EM, Chen KC, Porter NM. A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease. Current Alzheimer Research. 4: 205-12. PMID 17430248  1
2007 Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW. Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3098-110. PMID 17376971 DOI: 10.1523/JNEUROSCI.4163-06.2007  1
2006 Norris CM, Blalock EM, Thibault O, Brewer LD, Clodfelter GV, Porter NM, Landfield PW. Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release. Journal of Neurophysiology. 96: 2488-500. PMID 16914613 DOI: 10.1152/jn.00593.2005  1
2006 Brewer LD, Porter NM, Kerr DS, Landfield PW, Thibault O. Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging. Cell Calcium. 40: 277-86. PMID 16780945 DOI: 10.1016/j.ceca.2006.04.001  1
2006 Gant JC, Sama MM, Landfield PW, Thibault O. Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3482-90. PMID 16571755 DOI: 10.1523/JNEUROSCI.4171-05.2006  1
2005 Blalock EM, Chen KC, Stromberg AJ, Norris CM, Kadish I, Kraner SD, Porter NM, Landfield PW. Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation. Ageing Research Reviews. 4: 481-512. PMID 16257272 DOI: 10.1016/j.arr.2005.06.006  1
2005 Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD. Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4649-58. PMID 15872113 DOI: 10.1523/JNEUROSCI.0365-05.2005  1
2004 Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW. Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proceedings of the National Academy of Sciences of the United States of America. 101: 2173-8. PMID 14769913 DOI: 10.1073/pnas.0308512100  1
2003 Peng X, Wood CL, Blalock EM, Chen KC, Landfield PW, Stromberg AJ. Statistical implications of pooling RNA samples for microarray experiments. Bmc Bioinformatics. 4: 26. PMID 12823867 DOI: 10.1186/1471-2105-4-26  1
2003 Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW. Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3807-19. PMID 12736351  1
2002 Clodfelter GV, Porter NM, Landfield PW, Thibault O. Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons. European Journal of Pharmacology. 447: 189-200. PMID 12151011 DOI: 10.1016/S0014-2999(02)01843-5  1
2002 Verkhratsky A, Landfield PW, Thibault O. Preface. Ca2+ and neuronal pathology. European Journal of Pharmacology. 447: 115-7. PMID 12151003  1
2002 Attucci S, Clodfelter GV, Thibault O, Staton J, Moroni F, Landfield PW, Porter NM. Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity. Neuroscience. 112: 183-94. PMID 12044483 DOI: 10.1016/S0306-4522(02)00002-7  1
2002 Norris CM, Blalock EM, Chen KC, Porter NM, Landfield PW. Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture. Neuroscience. 110: 213-25. PMID 11958864 DOI: 10.1016/S0306-4522(01)00574-7  1
2001 Thibault O, Hadley R, Landfield PW. Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9744-56. PMID 11739583  1
2001 Blalock EM, Chen KC, Vanaman TC, Landfield PW, Slevin JT. Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices. Epilepsy Research. 43: 211-26. PMID 11248533 DOI: 10.1016/S0920-1211(00)00199-6  1
2001 Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 98-108. PMID 11150325  1
2000 Chen KC, Blalock EM, Thibault O, Kaminker P, Landfield PW. Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices. Proceedings of the National Academy of Sciences of the United States of America. 97: 4357-62. PMID 10759553 DOI: 10.1073/pnas.070056097  1
1999 Blalock EM, Porter NM, Landfield PW. Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8674-84. PMID 10493768  1
1998 Porter NM, Landfield PW. Stress hormones and brain aging: adding injury to insult? Nature Neuroscience. 1: 3-4. PMID 10195096 DOI: 10.1038/196  1
1998 Herman JP, Chen KC, Booze R, Landfield PW. Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats. Neurobiology of Aging. 19: 581-7. PMID 10192218  1
1998 Thibault O, Porter NM, Chen KC, Blalock EM, Kaminker PG, Clodfelter GV, Brewer LD, Landfield PW. Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions. Cell Calcium. 24: 417-33. PMID 10091010 DOI: 10.1016/S0143-4160(98)90064-1  1
1997 Smith CD, Landrum W, Carney JM, Landfield PW, Avison MJ. Brain creatine kinase with aging in F-344 rats: analysis by saturation transfer magnetic resonance spectroscopy. Neurobiology of Aging. 18: 617-22. PMID 9461059 DOI: 10.1016/S0197-4580(97)00156-5  1
1997 Porter NM, Thibault O, Thibault V, Chen KC, Landfield PW. Calcium channel density and hippocampal cell death with age in long-term culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5629-39. PMID 9204944  1
1996 Gallagher M, Landfield PW, McEwen B, Meaney MJ, Rapp PR, Sapolsky R, West MJ. Hippocampal neurodegeneration in aging. Science (New York, N.Y.). 274: 484-5. PMID 8927995  1
1996 Campbell LW, Hao SY, Thibault O, Blalock EM, Landfield PW. Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 6286-95. PMID 8815908  1
1996 Landfield PW, McEwan BS, Sapolsky RM, Meaney MJ. Hippocampal cell death. Science (New York, N.Y.). 272: 1249-51. PMID 8650531  1
1996 Thibault O, Landfield PW. Increase in single L-type calcium channels in hippocampal neurons during aging. Science (New York, N.Y.). 272: 1017-20. PMID 8638124  1
1995 Thibault O, Mazzanti ML, Blalock EM, Porter NM, Landfield PW. Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons. Journal of Neuroscience Methods. 59: 77-83. PMID 7475254  1
1995 Lipton P, Aitken PG, Dudek FE, Eskessen K, Espanol MT, Ferchmin PA, Kelly JB, Kreisman NR, Landfield PW, Larkman PM. Making the best of brain slices: comparing preparative methods. Journal of Neuroscience Methods. 59: 151-6. PMID 7475245  1
1993 Thibault O, Porter NM, Landfield PW. Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications. Proceedings of the National Academy of Sciences of the United States of America. 90: 11792-6. PMID 7505447  1
1992 Kerr DS, Campbell LW, Thibault O, Landfield PW. Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging. Proceedings of the National Academy of Sciences of the United States of America. 89: 8527-31. PMID 1528857  1
1992 Landfield PW, Thibault O, Mazzanti ML, Porter NM, Kerr DS. Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis. Journal of Neurobiology. 23: 1247-60. PMID 1469387 DOI: 10.1002/neu.480230914  1
1991 Kerr DS, Campbell LW, Applegate MD, Brodish A, Landfield PW. Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 1316-24. PMID 2027050  1
1991 Landfield PW, Applegate MD, Schmitzer-Osborne SE, Naylor CE. Phosphate/calcium alterations in the first stages of Alzheimer's disease: implications for etiology and pathogenesis. Journal of the Neurological Sciences. 106: 221-9. PMID 1802970 DOI: 10.1016/0022-510X(91)90261-5  1
1990 Pitler TA, Landfield PW. Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons. Brain Research. 508: 1-6. PMID 2337778 DOI: 10.1016/0006-8993(90)91109-T  1
1989 Kerr DS, Campbell LW, Hao SY, Landfield PW. Corticosteroid modulation of hippocampal potentials: increased effect with aging. Science (New York, N.Y.). 245: 1505-9. PMID 2781293  1
1989 Landfield PW, Campbell LW, Hao SY, Kerr DS. Aging-related increases in voltage-sensitive, inactivating calcium currents in rat hippocampus. Implications for mechanisms of brain aging and Alzheimer's disease. Annals of the New York Academy of Sciences. 568: 95-105. PMID 2560904 DOI: 10.1111/j.1749-6632.1989.tb12495.x  1
1988 Applegate MD, Landfield PW. Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 1096-111. PMID 3357011  1
1987 Pitler TA, Landfield PW. Postsynaptic membrane shifts during frequency potentiation of the hippocampal EPSP. Journal of Neurophysiology. 58: 866-82. PMID 3681399  1
1987 Applegate MD, Kerr DS, Landfield PW. Redistribution of synaptic vesicles during long-term potentiation in the hippocampus. Brain Research. 401: 401-6. PMID 3028579 DOI: 10.1016/0006-8993(87)91429-6  1
1987 Pitler TA, Landfield PW. Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons. Brain Research. 410: 147-53. PMID 2438012 DOI: 10.1016/S0006-8993(87)80037-9  1
1986 Landfield PW, Pitler TA, Applegate MD. The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats. Journal of Neurophysiology. 56: 797-811. PMID 3783221  1
1984 Landfield PW, Pitler TA. Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats. Science (New York, N.Y.). 226: 1089-92. PMID 6494926  1
1984 Landfield PW, Morgan GA. Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats. Brain Research. 322: 167-71. PMID 6097334 DOI: 10.1016/0006-8993(84)91199-5  1
1984 Poole LB, Liu MS, Landfield PW. Kinetic studies of the Na+-K+-ATPase enzyme system in brain and heart of aging rats. The American Journal of Physiology. 247: R850-5. PMID 6093604  1
1981 Landfield PW, Braun LD, Pitler TA, Lindsey JD, Lynch G. Hippocampal aging in rats: a morphometric study of multiple variables in semithin sections. Neurobiology of Aging. 2: 265-75. PMID 7335145 DOI: 10.1016/0197-4580(81)90034-8  1
1981 Landfield PW, Baskin RK, Pitler TA. Brain aging correlates: retardation by hormonal-pharmacological treatments. Science (New York, N.Y.). 214: 581-4. PMID 6270791  1
1979 Landfield PW, Wurtz C, Lindsey JD. Quantification of synaptic vesicles in hippocampus of aging rats and initial studies of possible relations to neurophysiology. Brain Research Bulletin. 4: 757-63. PMID 526857 DOI: 10.1016/0361-9230(79)90009-1  1
1979 Lindsey JD, Landfield PW, Lynch G. Early onset and topographical distribution of hypertrophied astrocytes in hippocampus of aging rats: a quantitative study. Journal of Gerontology. 34: 661-71. PMID 469184  1
1978 Landfield PW, Waymire JC, Lynch G. Hippocampal aging and adrenocorticoids: quantitative correlations. Science (New York, N.Y.). 202: 1098-102. PMID 715460  1
1978 Landfield PW, McGaugh JL, Lynch G. Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats. Brain Research. 150: 85-101. PMID 208716 DOI: 10.1016/0006-8993(78)90655-8  1
1973 Landfield PW, Tusa RJ, McGaugh JL. Effects of posttrial hippocampal stimulation on memory storage and EEG activity. Behavioral Biology. 8: 485-505. PMID 4574546 DOI: 10.1016/S0091-6773(73)80042-2  1
1972 Landfield PW, McGaugh JL. Effects of electroconvulsive shock and brain stimulation on EEG cortical theta rhythms in rats. Behavioral Biology. 7: 271-8. PMID 5041866 DOI: 10.1016/S0091-6773(72)80206-2  1
1972 Landfield PW, McGaugh JL, Tusa RJ. Theta rhythm: a temporal correlate of memory storage processes in the rat. Science (New York, N.Y.). 175: 87-9. PMID 5008585  1
1970 McGaugh JL, Landfield PW. Delayed development of amnesia following electroconvulsive shock. Physiology & Behavior. 5: 1109-13. PMID 5535671 DOI: 10.1016/0031-9384(70)90197-6  1
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