Michael J. Strong, MD, FRCP(C), FANN, FCAHS - Publications

Affiliations: 
Clinical Neurological Sciences University of Western Ontario, London, Ontario, Canada 
Website:
http://www.cnsuwo.ca/faculty/neurologists/michael-strong/

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Strong MJ, Donison NS, Volkening K. Alterations in Tau Metabolism in ALS and ALS-FTSD. Frontiers in Neurology. 11: 598907. PMID 33329356 DOI: 10.3389/fneur.2020.598907  0.301
2020 Di Gregorio SE, Volkening K, Strong MJ, Duennwald ML. Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network. International Journal of Molecular Sciences. 21. PMID 32764283 DOI: 10.3390/Ijms21165597  0.402
2019 Droppelmann CA, Campos-Melo D, Moszczynski AJ, Amzil H, Strong MJ. TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS. Scientific Reports. 9: 19928. PMID 31882736 DOI: 10.1038/S41598-019-56483-Y  0.395
2019 Hintermayer MA, Volkening K, Moszczynski AJ, Donison N, Strong MJ. Tau protein phosphorylation at Thr initiates fibril formation via accessibility of the N-terminal phosphatase-activating domain. Journal of Neurochemistry. e14942. PMID 31853971 DOI: 10.1111/Jnc.14942  0.739
2019 Moszczynski AJ, Harvey M, Fulcher N, de Oliveira C, McCunn P, Donison N, Bartha R, Schmid S, Strong MJ, Volkening K. Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43 and tau protein. Acta Neuropathologica Communications. 7: 170. PMID 31703746 DOI: 10.1186/S40478-019-0816-1  0.341
2019 Ross JP, Leblond CS, Catoire H, Volkening K, Strong M, Zinman L, Robertson J, Dion PA, Rouleau GA. Somatic expansion of the hexanucleotide repeat does not occur in ALS spinal cord tissues. Neurology. Genetics. 5: e317. PMID 31041398 DOI: 10.1212/Nxg.0000000000000317  0.309
2018 Hawley ZCE, Campos-Melo D, Strong MJ. MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS). Brain Research. PMID 30385300 DOI: 10.1016/J.Brainres.2018.10.032  0.312
2018 Strong MJ. Author response: Pathologic Thr tau phosphorylation in CTE and CTE with ALS. Neurology. 91: 579. PMID 30224505 DOI: 10.1212/Wnl.0000000000006194  0.375
2018 Campos-Melo D, Hawley ZCE, Strong MJ. Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs. Molecular Brain. 11: 43. PMID 30029677 DOI: 10.1186/S13041-018-0386-3  0.363
2018 Moszczynski AJ, Gopaul J, McCunn P, Volkening K, Harvey M, Bartha R, Schmid S, Strong MJ. Somatic Gene Transfer Using a Recombinant Adenoviral Vector (rAAV9) Encoding Pseudophosphorylated Human Thr175 Tau in Adult Rat Hippocampus Induces Tau Pathology. Journal of Neuropathology and Experimental Neurology. PMID 29878234 DOI: 10.1093/Jnen/Nly044  0.34
2018 Moszczynski AJ, Hintermayer MA, Strong MJ. Phosphorylation of Threonine 175 Tau in the Induction of Tau Pathology in Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder (ALS-FTSD). A Review. Frontiers in Neuroscience. 12: 259. PMID 29731706 DOI: 10.3389/Fnins.2018.00259  0.761
2018 Deshaies JE, Shkreta L, Moszczynski AJ, Sidibé H, Semmler S, Fouillen A, Bennett ER, Bekenstein U, Destroismaisons L, Toutant J, Delmotte Q, Volkening K, Stabile S, Aulas A, Khalfallah Y, ... ... Strong MJ, et al. TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis. Brain : a Journal of Neurology. PMID 29562314 DOI: 10.1093/Brain/Awy062  0.367
2018 Volkening K, Keller B, Leysta-Lantz C, Strong MJ. RNA and protein interactors with TDP-43 in human spinal cord lysates in ALS. Journal of Proteome Research. PMID 29513014 DOI: 10.1021/Acs.Jproteome.8B00126  0.362
2018 Moszczynski AJ, Strong W, Xu K, McKee A, Brown A, Strong MJ. Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS. Neurology. PMID 29298849 DOI: 10.1212/Wnl.0000000000004899  0.362
2017 Tortarolo M, Lo Coco D, Veglianese P, Vallarola A, Giordana MT, Marcon G, Beghi E, Poloni M, Strong MJ, Iyer AM, Aronica E, Bendotti C. Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFα. Mediators of Inflammation. 2017: 2985051. PMID 29081600 DOI: 10.1155/2017/2985051  0.383
2017 Farhan SMK, Gendron TF, Petrucelli L, Hegele RA, Strong MJ. OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 29080331 DOI: 10.1002/Ajmg.B.32606  0.359
2017 Hawley ZCE, Campos-Melo D, Strong MJ. Novel miR-b2122 regulates several ALS-related RNA-binding proteins. Molecular Brain. 10: 46. PMID 28969660 DOI: 10.1186/S13041-017-0326-7  0.307
2017 Strong MJ. Revisiting the concept of amyotrophic lateral sclerosis as a multisystems disorder of limited phenotypic expression. Current Opinion in Neurology. PMID 28914734 DOI: 10.1097/Wco.0000000000000488  0.373
2017 Montero-Odasso M, Pieruccini-Faria F, Bartha R, Black SE, Finger E, Freedman M, Greenberg B, Grimes DA, Hegele RA, Hudson C, Kleinstiver PW, Lang AE, Masellis M, McLaughlin PM, Munoz DP, ... ... Strong MJ, et al. Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). Journal of Alzheimer's Disease : Jad. PMID 28671116 DOI: 10.3233/Jad-170149  0.314
2017 Volkening K, Strong WL, Seaton S, Yang W, Strong MJ. C9orf72 mutations do not influence the tau signature of amyotrophic lateral sclerosis with cognitive impairment (ALSci). Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-6. PMID 28562075 DOI: 10.1080/21678421.2017.1332075  0.357
2017 Hawley ZCE, Campos-Melo D, Droppelmann CA, Strong MJ. MotomiRs: miRNAs in Motor Neuron Function and Disease. Frontiers in Molecular Neuroscience. 10: 127. PMID 28522960 DOI: 10.3389/Fnmol.2017.00127  0.307
2017 Cheung K, Droppelmann CA, MacLellan A, Cameron I, Withers B, Campos-Melo D, Volkening K, Strong MJ. Rho guanine nucleotide exchange factor (RGNEF) is a prosurvival factor under stress conditions. Molecular and Cellular Neurosciences. PMID 28495450 DOI: 10.1016/J.Mcn.2017.05.003  0.326
2017 Moszczynski AJ, Yang W, Hammond R, Ang LC, Strong MJ. Threonine(175), a novel pathological phosphorylation site on tau protein linked to multiple tauopathies. Acta Neuropathologica Communications. 5: 6. PMID 28077166 DOI: 10.1186/S40478-016-0406-4  0.344
2017 Strong MJ, Abrahams S, Goldstein LH, Woolley S, Mclaughlin P, Snowden J, Mioshi E, Roberts-South A, Benatar M, HortobáGyi T, Rosenfeld J, Silani V, Ince PG, Turner MR. Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-22. PMID 28054827 DOI: 10.1080/21678421.2016.1267768  0.354
2016 Farhan SMK, Dilliott AA, Ghani M, Sato C, Liang E, Zhang M, McIntyre AD, Cao H, Racacho L, Robinson JF, Strong MJ, Masellis M, St George-Hyslop P, Bulman DE, Rogaeva E, et al. The ONDRISeq panel: custom-designed next-generation sequencing of genes related to neurodegeneration. Npj Genomic Medicine. 1: 16032. PMID 29263818 DOI: 10.1038/Npjgenmed.2016.32  0.307
2016 Behrouzi R, Liu X, Wu D, Robinson AC, Tanaguchi-Watanabe S, Rollinson S, Shi J, Tian J, Hamdalla HH, Ealing J, Richardson A, Jones M, Pickering-Brown S, Davidson YS, Strong MJ, et al. Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy. Acta Neuropathologica Communications. 4: 33. PMID 27036121 DOI: 10.1186/S40478-016-0301-Z  0.367
2015 Woolley SC, Strong MJ. Frontotemporal Dysfunction and Dementia in Amyotrophic Lateral Sclerosis. Neurologic Clinics. 33: 787-805. PMID 26515622 DOI: 10.1016/J.Ncl.2015.07.011  0.367
2015 Moszczynski AJ, Gohar M, Volkening K, Leystra-Lantz C, Strong W, Strong MJ. Thr175-phosphorylated tau induces pathologic fibril formation via GSK3β-mediated phosphorylation of Thr231 in vitro. Neurobiology of Aging. 36: 1590-9. PMID 25573097 DOI: 10.1016/J.Neurobiolaging.2014.12.001  0.346
2015 Rosenfeld J, Strong MJ. Challenges in the Understanding and Treatment of Amyotrophic Lateral Sclerosis/Motor Neuron Disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 317-25. PMID 25572957 DOI: 10.1007/S13311-014-0332-8  0.355
2015 Tibshirani M, Tradewell ML, Mattina KR, Minotti S, Yang W, Zhou H, Strong MJ, Hayward LJ, Durham HD. Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1. Human Molecular Genetics. 24: 773-86. PMID 25274782 DOI: 10.1093/Hmg/Ddu494  0.379
2014 Droppelmann CA, Campos-Melo D, Volkening K, Strong MJ. The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases. Frontiers in Cellular Neuroscience. 8: 282. PMID 25309324 DOI: 10.3389/Fncel.2014.00282  0.342
2014 van Blitterswijk M, Mullen B, Wojtas A, Heckman MG, Diehl NN, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, ... ... Strong MJ, et al. Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Molecular Neurodegeneration. 9: 38. PMID 25239657 DOI: 10.1186/1750-1326-9-38  0.315
2014 Gargiulo-Monachelli GM, Campos-Melo D, Droppelmann CA, Keller BA, Leystra-Lantz C, De Nicola AF, Gonzalez Deniselle MC, Volkening K, Strong MJ. Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 21: 273-80.e11. PMID 24894997 DOI: 10.1111/Ene.12291  0.34
2014 van Blitterswijk M, Mullen B, Heckman MG, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, ... ... Strong MJ, et al. Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers. Neurobiology of Aging. 35: 2421.e13-7. PMID 24866401 DOI: 10.1016/J.Neurobiolaging.2014.04.016  0.353
2014 Droppelmann CA, Campos-Melo D, Ishtiaq M, Volkening K, Strong MJ. RNA metabolism in ALS: when normal processes become pathological. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 15: 321-36. PMID 24555412 DOI: 10.3109/21678421.2014.881377  0.342
2013 Campos-Melo D, Droppelmann CA, He Z, Volkening K, Strong MJ. Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels. Molecular Brain. 6: 26. PMID 23705811 DOI: 10.1186/1756-6606-6-26  0.334
2013 Al-Chalabi A, Kwak S, Mehler M, Rouleau G, Siddique T, Strong M, Leigh PN. Genetic and epigenetic studies of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 44-52. PMID 23678879 DOI: 10.3109/21678421.2013.778571  0.302
2013 Fournier C, Bedlack B, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, ... ... Strong M, et al. ALS Untangled No. 20: the Deanna protocol. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 319-23. PMID 23638638 DOI: 10.3109/21678421.2013.788405  0.309
2013 Droppelmann CA, Wang J, Campos-Melo D, Keller B, Volkening K, Hegele RA, Strong MJ. Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 444-51. PMID 23286752 DOI: 10.3109/21678421.2012.758288  0.364
2013 Droppelmann CA, Keller BA, Campos-Melo D, Volkening K, Strong MJ. Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis. Neurobiology of Aging. 34: 248-62. PMID 22835604 DOI: 10.1016/J.Neurobiolaging.2012.06.021  0.416
2013 Belzil VV, Daoud H, Camu W, Strong MJ, Dion PA, Rouleau GA. Genetic analysis of SIGMAR1 as a cause of familial ALS with dementia. European Journal of Human Genetics : Ejhg. 21: 237-9. PMID 22739338 DOI: 10.1038/Ejhg.2012.135  0.353
2012 Daoud H, Suhail H, Sabbagh M, Belzil V, Szuto A, Dionne-Laporte A, Khoris J, Camu W, Salachas F, Meininger V, Mathieu J, Strong M, Dion PA, Rouleau GA. C9orf72 hexanucleotide repeat expansions as the causative mutation for chromosome 9p21-linked amyotrophic lateral sclerosis and frontotemporal dementia. Archives of Neurology. 69: 1159-63. PMID 22964911 DOI: 10.1001/Archneurol.2012.377  0.32
2012 Keller BA, Volkening K, Droppelmann CA, Ang LC, Rademakers R, Strong MJ. Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism. Acta Neuropathologica. 124: 733-47. PMID 22941224 DOI: 10.1007/S00401-012-1035-Z  0.408
2012 Bedlack R, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, Dimachkie M, Wang Y, ... ... Strong M, et al. ALS untangled no. 17: "When ALS Is Lyme" Amyotrophic Lateral Sclerosis. 13: 487-491. PMID 22873562 DOI: 10.3109/17482968.2012.717796  0.319
2012 Rutherford NJ, Heckman MG, Dejesus-Hernandez M, Baker MC, Soto-Ortolaza AI, Rayaprolu S, Stewart H, Finger E, Volkening K, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, ... ... Strong MJ, et al. Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype. Neurobiology of Aging. 33: 2950.e5-7. PMID 22840558 DOI: 10.1016/J.Neurobiolaging.2012.07.005  0.337
2012 Kabashi E, Agar JN, Strong MJ, Durham HD. Impaired proteasome function in sporadic amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 13: 367-71. PMID 22632443 DOI: 10.3109/17482968.2012.686511  0.382
2012 Roberts-South A, Findlater K, Strong MJ, Orange JB. Longitudinal changes in discourse production in amyotrophic lateral sclerosis. Seminars in Speech and Language. 33: 79-94. PMID 22362326 DOI: 10.1055/S-0031-1301165  0.314
2012 Murphy MJ, Grace GM, Tartaglia MC, Orange JB, Chen X, Rowe A, Findlater K, Kozak RI, Freedman M, Lee TY, Strong MJ. Widespread cerebral haemodynamics disturbances occur early in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 13: 202-9. PMID 22292841 DOI: 10.3109/17482968.2011.625569  0.302
2012 Yang W, Strong MJ. Widespread neuronal and glial hyperphosphorylated tau deposition in ALS with cognitive impairment. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 13: 178-93. PMID 22214313 DOI: 10.3109/17482968.2011.622405  0.385
2012 Gargiulo Monachelli G, Campos-Melo D, Droppelmann C, Keller B, De Nicola A, Gonzalez Deniselle MC, Volkening K, Strong M. Expression and Cellular Localization of the Classical Progesterone Receptor (PR) in the Spinal Cord of Control Subjects and Amyotrophic Lateral Sclerosis (ALS) Patients (P05.170) Neurology. 78: P05.170-P05.170. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P05.170  0.302
2011 Ince PG, Highley JR, Kirby J, Wharton SB, Takahashi H, Strong MJ, Shaw PJ. Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology. Acta Neuropathologica. 122: 657-71. PMID 22105541 DOI: 10.1007/S00401-011-0913-0  0.394
2011 Swarup V, Phaneuf D, Dupré N, Petri S, Strong M, Kriz J, Julien JP. Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways. The Journal of Experimental Medicine. 208: 2429-47. PMID 22084410 DOI: 10.1084/Jem.20111313  0.37
2011 Strong MJ, Volkening K. TDP-43 and FUS/TLS: sending a complex message about messenger RNA in amyotrophic lateral sclerosis? The Febs Journal. 278: 3569-77. PMID 21810174 DOI: 10.1111/J.1742-4658.2011.08277.X  0.372
2011 Strong MJ, Yang W. The frontotemporal syndromes of ALS. Clinicopathological correlates. Journal of Molecular Neuroscience : Mn. 45: 648-55. PMID 21809041 DOI: 10.1007/S12031-011-9609-0  0.412
2011 Ross OA, Rutherford NJ, Baker M, Soto-Ortolaza AI, Carrasquillo MM, DeJesus-Hernandez M, Adamson J, Li M, Volkening K, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, ... ... Strong MJ, et al. Ataxin-2 repeat-length variation and neurodegeneration. Human Molecular Genetics. 20: 3207-12. PMID 21610160 DOI: 10.1093/Hmg/Ddr227  0.345
2011 Mackenzie IR, Ansorge O, Strong M, Bilbao J, Zinman L, Ang LC, Baker M, Stewart H, Eisen A, Rademakers R, Neumann M. Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation. Acta Neuropathologica. 122: 87-98. PMID 21604077 DOI: 10.1007/S00401-011-0838-7  0.324
2011 Grace GM, Orange JB, Rowe A, Findlater K, Freedman M, Strong MJ. Neuropsychological functioning in PLS: a comparison with ALS. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 38: 88-97. PMID 21156436 DOI: 10.1017/S0317167100120803  0.31
2011 Strong MJ, Yang W, Gohar M, Strong WL. Dementia with motor neuron disease Clinical Neurology. 51: 935. DOI: 10.5692/Clinicalneurol.51.935  0.414
2010 Rudrabhatla P, Grant P, Jaffe H, Strong MJ, Pant HC. Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4396-407. PMID 20624930 DOI: 10.1096/Fj.10-157859  0.304
2010 Ritsma BR, Berger MJ, Charland DA, Khoury MA, Phillips JT, Quon MJ, Strong MJ, Schulz VM. NIPPV: prevalence, approach and barriers to use at Canadian ALS centres. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 37: 54-60. PMID 20169774 DOI: 10.1017/S0317167100009653  0.312
2010 Szaro BG, Strong MJ. Post-transcriptional control of neurofilaments: New roles in development, regeneration and neurodegenerative disease. Trends in Neurosciences. 33: 27-37. PMID 19906448 DOI: 10.1016/J.Tins.2009.10.002  0.307
2010 Strong MJ. The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS). Journal of the Neurological Sciences. 288: 1-12. PMID 19840884 DOI: 10.1016/J.Jns.2009.09.029  0.373
2009 Basso M, Samengo G, Nardo G, Massignan T, D'Alessandro G, Tartari S, Cantoni L, Marino M, Cheroni C, De Biasi S, Giordana MT, Strong MJ, Estevez AG, Salmona M, Bendotti C, et al. Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis. Plos One. 4: e8130. PMID 19956584 DOI: 10.1371/Journal.Pone.0008130  0.375
2009 Volkening K, Leystra-Lantz C, Yang W, Jaffee H, Strong MJ. Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS). Brain Research. 1305: 168-82. PMID 19815002 DOI: 10.1016/J.Brainres.2009.09.105  0.405
2009 Liu HN, Sanelli T, Horne P, Pioro EP, Strong MJ, Rogaeva E, Bilbao J, Zinman L, Robertson J. Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis. Annals of Neurology. 66: 75-80. PMID 19670443 DOI: 10.1002/Ana.21704  0.337
2009 Moisse K, Mepham J, Volkening K, Welch I, Hill T, Strong MJ. Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury. Brain Research. 1296: 176-86. PMID 19619516 DOI: 10.1016/J.Brainres.2009.07.023  0.316
2009 Strong MJ, Grace GM, Freedman M, Lomen-Hoerth C, Woolley S, Goldstein LH, Murphy J, Shoesmith C, Rosenfeld J, Leigh PN, Bruijn L, Ince P, Figlewicz D. Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 10: 131-46. PMID 19462523 DOI: 10.1080/17482960802654364  0.354
2009 Tartaglia MC, Laluz V, Rowe A, Findlater K, Lee DH, Kennedy K, Kramer JH, Strong MJ. Brain atrophy in primary lateral sclerosis. Neurology. 72: 1236-41. PMID 19349603 DOI: 10.1212/01.Wnl.0000345665.75512.F9  0.303
2009 Humayun S, Gohar M, Volkening K, Moisse K, Leystra-Lantz C, Mepham J, McLean J, Strong MJ. The complement factor C5a receptor is upregulated in NFL-/- mouse motor neurons. Journal of Neuroimmunology. 210: 52-62. PMID 19286267 DOI: 10.1016/J.Jneuroim.2009.01.028  0.348
2009 Moisse K, Volkening K, Leystra-Lantz C, Welch I, Hill T, Strong MJ. Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury. Brain Research. 1249: 202-11. PMID 19046946 DOI: 10.1016/J.Brainres.2008.10.021  0.319
2009 Gohar M, Yang W, Strong W, Volkening K, Leystra-Lantz C, Strong MJ. Tau phosphorylation at threonine-175 leads to fibril formation and enhanced cell death: implications for amyotrophic lateral sclerosis with cognitive impairment. Journal of Neurochemistry. 108: 634-43. PMID 19046355 DOI: 10.1111/J.1471-4159.2008.05791.X  0.373
2008 Strong MJ. The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 9: 323-38. PMID 18752088 DOI: 10.1080/17482960802372371  0.357
2008 Moisse K, Welch I, Hill T, Volkening K, Strong MJ. Transient middle cerebral artery occlusion induces microglial priming in the lumbar spinal cord: a novel model of neuroinflammation. Journal of Neuroinflammation. 5: 29. PMID 18606006 DOI: 10.1186/1742-2094-5-29  0.307
2008 Xiao S, Tjostheim S, Sanelli T, McLean JR, Horne P, Fan Y, Ravits J, Strong MJ, Robertson J. An aggregate-inducing peripherin isoform generated through intron retention is upregulated in amyotrophic lateral sclerosis and associated with disease pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1833-40. PMID 18287500 DOI: 10.1523/Jneurosci.3222-07.2008  0.422
2008 Yang W, Leystra-Lantz C, Strong MJ. Upregulation of GSK3beta expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci). Brain Research. 1196: 131-9. PMID 18221734 DOI: 10.1016/J.Brainres.2007.12.031  0.378
2007 Kesavapany S, Patel V, Zheng YL, Pareek TK, Bjelogrlic M, Albers W, Amin N, Jaffe H, Gutkind JS, Strong MJ, Grant P, Pant HC. Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Molecular Biology of the Cell. 18: 3645-55. PMID 17626162 DOI: 10.1091/Mbc.E07-03-0237  0.356
2007 Robertson J, Sanelli T, Xiao S, Yang W, Horne P, Hammond R, Pioro EP, Strong MJ. Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS. Neuroscience Letters. 420: 128-32. PMID 17543992 DOI: 10.1016/J.Neulet.2007.03.066  0.393
2007 Strong MJ, Volkening K, Hammond R, Yang W, Strong W, Leystra-Lantz C, Shoesmith C. TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Molecular and Cellular Neurosciences. 35: 320-7. PMID 17481916 DOI: 10.1016/J.Mcn.2007.03.007  0.385
2007 Sanelli T, Ge W, Leystra-Lantz C, Strong MJ. Calcium mediated excitotoxicity in neurofilament aggregate-bearing neurons in vitro is NMDA receptor dependant. Journal of the Neurological Sciences. 256: 39-51. PMID 17368487 DOI: 10.1016/J.Jns.2007.02.018  0.301
2007 Tartaglia MC, Rowe A, Findlater K, Orange JB, Grace G, Strong MJ. Differentiation between primary lateral sclerosis and amyotrophic lateral sclerosis: examination of symptoms and signs at disease onset and during follow-up. Archives of Neurology. 64: 232-6. PMID 17296839 DOI: 10.1001/Archneur.64.2.232  0.369
2007 Sanelli T, Strong MJ. Loss of nitric oxide-mediated down-regulation of NMDA receptors in neurofilament aggregate-bearing motor neurons in vitro: implications for motor neuron disease. Free Radical Biology & Medicine. 42: 143-51. PMID 17157201 DOI: 10.1016/J.Freeradbiomed.2006.10.041  0.326
2007 Shoesmith CL, Findlater K, Rowe A, Strong MJ. Prognosis of amyotrophic lateral sclerosis with respiratory onset. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 629-31. PMID 17088331 DOI: 10.1136/Jnnp.2006.103564  0.319
2006 Strong MJ, Yang W, Strong WL, Leystra-Lantz C, Jaffe H, Pant HC. Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment. Neurology. 66: 1770-1. PMID 16769962 DOI: 10.1212/01.Wnl.0000218161.15834.Db  0.355
2006 Ge WW, Leystra-Lantz C, Sanelli TR, McLean J, Wen W, Strong W, Strong MJ. Neuronal tissue-specific ribonucleoprotein complex formation on SOD1 mRNA: alterations by ALS SOD1 mutations. Neurobiology of Disease. 23: 342-50. PMID 16730180 DOI: 10.1016/J.Nbd.2006.03.007  0.366
2006 Moisse K, Strong MJ. Innate immunity in amyotrophic lateral sclerosis. Biochimica Et Biophysica Acta. 1762: 1083-93. PMID 16624536 DOI: 10.1016/J.Bbadis.2006.03.001  0.385
2006 Strong MJ. ALS--not what we thought. Archives of Neurology. 63: 319-20. PMID 16533957 DOI: 10.1001/Archneur.63.3.319  0.322
2006 Wen W, Sanelli T, Ge W, Strong W, Strong MJ. Activated microglial supernatant induced motor neuron cytotoxicity is associated with upregulation of the TNFR1 receptor. Neuroscience Research. 55: 87-95. PMID 16529832 DOI: 10.1016/J.Neures.2006.02.004  0.31
2005 Yang W, Ang LC, Strong MJ. Tau protein aggregation in the frontal and entorhinal cortices as a function of aging. Brain Research. Developmental Brain Research. 156: 127-38. PMID 16110532 DOI: 10.1016/J.Devbrainres.2005.02.004  0.347
2005 Strong MJ, Kesavapany S, Pant HC. The pathobiology of amyotrophic lateral sclerosis: a proteinopathy? Journal of Neuropathology and Experimental Neurology. 64: 649-64. PMID 16106213 DOI: 10.1097/01.Jnen.0000173889.71434.Ea  0.432
2005 Strong MJ, Gordon PH. Primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis: discrete entities or spectrum? Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 6: 8-16. PMID 16036421 DOI: 10.1080/14660820410021267  0.369
2005 McLean JR, Sanelli TR, Leystra-Lantz C, He BP, Strong MJ. Temporal profiles of neuronal degeneration, glial proliferation, and cell death in hNFL(+/+) and NFL(-/-) mice. Glia. 52: 59-69. PMID 15920739 DOI: 10.1002/Glia.20218  0.368
2005 Ge WW, Wen W, Strong W, Leystra-Lantz C, Strong MJ. Mutant copper-zinc superoxide dismutase binds to and destabilizes human low molecular weight neurofilament mRNA. The Journal of Biological Chemistry. 280: 118-24. PMID 15507437 DOI: 10.1074/Jbc.M405065200  0.301
2004 Levchenko A, Robitaille Y, Strong MJ, Rouleau GA. TAU mutations are not a predominant cause of frontotemporal dementia in Canadian patients. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 31: 363-7. PMID 15376481 DOI: 10.1017/S0317167100003450  0.328
2004 Sanelli TR, Sopper MM, Strong MJ. Sequestration of nNOS in neurofilamentous aggregate bearing neurons in vitro leads to enhanced NMDA-mediated calcium influx. Brain Research. 1004: 8-17. PMID 15033415 DOI: 10.1016/J.Brainres.2003.12.035  0.336
2004 Strong MJ, Leystra-Lantz C, Ge WW. Intermediate filament steady-state mRNA levels in amyotrophic lateral sclerosis. Biochemical and Biophysical Research Communications. 316: 317-22. PMID 15020220 DOI: 10.1016/J.Bbrc.2004.02.051  0.36
2004 Bendotti C, Atzori C, Piva R, Tortarolo M, Strong MJ, DeBiasi S, Migheli A. Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice. Journal of Neuropathology and Experimental Neurology. 63: 113-9. PMID 14989597 DOI: 10.1093/Jnen/63.2.113  0.422
2003 Yang W, Sopper MM, Leystra-Lantz C, Strong MJ. Microtubule-associated tau protein positive neuronal and glial inclusions in ALS. Neurology. 61: 1766-73. PMID 14694044 DOI: 10.1212/01.Wnl.0000099372.75786.F8  0.401
2003 Strong MJ, Sopper M, He BP. In vitro reactive nitrating species toxicity in dissociated spinal motor neurons from NFL (-/-) and hNFL (+/+) transgenic mice Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 4: 81-89. PMID 14506938 DOI: 10.1080/14660820310012727  0.332
2003 Strong MJ, Rosenfeld J. Amyotrophic lateral sclerosis: A review of current concepts Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 4: 136-143. PMID 13129799 DOI: 10.1080/14660820310011250  0.37
2003 Mitsumoto H, Davidson M, Moore D, Gad N, Brandis M, Ringel S, Rosenfeld J, Shefner JM, Strong MJ, Sufit R, Anderson FA. Percutaneous endoscopic gastrostomy (PEG) in patients with ALS and bulbar dysfunction. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 4: 177-85. PMID 13129795 DOI: 10.1080/14660820310011728  0.304
2003 Batulan Z, Shinder GA, Minotti S, He BP, Doroudchi MM, Nalbantoglu J, Strong MJ, Durham HD. High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5789-98. PMID 12843283 DOI: 10.1523/Jneurosci.23-13-05789.2003  0.36
2003 Strong MJ, Lomen-Hoerth C, Caselli RJ, Bigio EH, Yang W. Cognitive impairment, frontotemporal dementia, and the motor neuron diseases. Annals of Neurology. 54: S20-3. PMID 12833364 DOI: 10.1002/Ana.10574  0.325
2003 Strong MJ. The basic aspects of therapeutics in amyotrophic lateral sclerosis. Pharmacology & Therapeutics. 98: 379-414. PMID 12782245 DOI: 10.1016/S0163-7258(03)00040-8  0.379
2003 Ge WW, Leystra-Lantz C, Wen W, Strong MJ. Selective loss of trans-acting instability determinants of neurofilament mRNA in amyotrophic lateral sclerosis spinal cord. The Journal of Biological Chemistry. 278: 26558-63. PMID 12730211 DOI: 10.1074/Jbc.M302886200  0.359
2003 Robertson J, Doroudchi MM, Nguyen MD, Durham HD, Strong MJ, Shaw G, Julien JP, Mushynski WE. A neurotoxic peripherin splice variant in a mouse model of ALS. The Journal of Cell Biology. 160: 939-49. PMID 12642616 DOI: 10.1083/Jcb.200205027  0.39
2002 He BP, Wen W, Strong MJ. Activated microglia (BV-2) facilitation of TNF-alpha-mediated motor neuron death in vitro. Journal of Neuroimmunology. 128: 31-8. PMID 12098508 DOI: 10.1016/S0165-5728(02)00141-8  0.302
2002 He BP, Strong MJ. Aluminum inhibition of microglial function in vitro Journal of Trace Elements in Experimental Medicine. 15: 141-152. DOI: 10.1002/Jtra.10012  0.336
2001 Strong MJ. Progress in clinical neurosciences: the evidence for ALS as a multisystems disorder of limited phenotypic expression. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 28: 283-98. PMID 11766772 DOI: 10.1017/S0317167100001505  0.407
2001 Wilson CM, Grace GM, Munoz DG, He BP, Strong MJ. Cognitive impairment in sporadic ALS: a pathologic continuum underlying a multisystem disorder. Neurology. 57: 651-7. PMID 11524474 DOI: 10.1212/Wnl.57.4.651  0.341
2001 Strong MJ, Strong WL, Jaffe H, Traggert B, Sopper MM, Pant HC. Phosphorylation state of the native high-molecular-weight neurofilament subunit protein from cervical spinal cord in sporadic amyotrophic lateral sclerosis. Journal of Neurochemistry. 76: 1315-25. PMID 11238716 DOI: 10.1046/J.1471-4159.2001.00094.X  0.378
2000 Wong NK, He BP, Strong MJ. Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic amyotrophic lateral sclerosis (ALS). Journal of Neuropathology and Experimental Neurology. 59: 972-82. PMID 11089575 DOI: 10.1093/Jnen/59.11.972  0.404
2000 He BP, Strong MJ. A morphological analysis of the motor neuron degeneration and microglial reaction in acute and chronic in vivo aluminum chloride neurotoxicity. Journal of Chemical Neuroanatomy. 17: 207-15. PMID 10697247 DOI: 10.1016/S0891-0618(99)00038-1  0.384
2000 Strong MJ, He B. Motor neuron disease and trace element toxicity Journal of Trace Elements in Experimental Medicine. 13: 131-140. DOI: 10.1002/(Sici)1520-670X(2000)13:1<131::Aid-Jtra14>3.0.Co;2-E  0.391
1999 Strong MJ, Grace GM, Orange JB, Leeper HA, Menon RS, Aere C. A prospective study of cognitive impairment in ALS. Neurology. 53: 1665-70. PMID 10563610 DOI: 10.1212/Wnl.53.8.1665  0.322
1999 Strong MJ. Neurofilament metabolism in sporadic amyotrophic lateral sclerosis. Journal of the Neurological Sciences. 169: 170-7. PMID 10540027 DOI: 10.1016/S0022-510X(99)00241-5  0.419
1998 Wong NK, Strong MJ. Nitric oxide synthase expression in cervical spinal cord in sporadic amyotrophic lateral sclerosis. European Journal of Cell Biology. 77: 338-43. PMID 9930658 DOI: 10.1016/S0171-9335(98)80092-7  0.355
1998 Strong MJ, Sopper MM, Crow JP, Strong WL, Beckman JS. Nitration of the low molecular weight neurofilament is equivalent in sporadic amyotrophic lateral sclerosis and control cervical spinal cord. Biochemical and Biophysical Research Communications. 248: 157-64. PMID 9675103 DOI: 10.1006/Bbrc.1998.8930  0.332
1997 Crow JP, Ye YZ, Strong M, Kirk M, Barnes S, Beckman JS. Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-L. Journal of Neurochemistry. 69: 1945-53. PMID 9349539 DOI: 10.1046/J.1471-4159.1997.69051945.X  0.302
1996 Wakayama I, Nerurkar VR, Strong MJ, Garruto RM. Comparative study of chronic aluminum-induced neurofilamentous aggregates with intracytoplasmic inclusions of amyotrophic lateral sclerosis. Acta Neuropathologica. 92: 545-54. PMID 8960311 DOI: 10.1007/S004010050560  0.623
1996 Brooke MH, Strong MJ. Advances in ALS workshop summary: Research and future goals. Neurology. 47: S108-12. PMID 8858063 DOI: 10.1212/Wnl.47.4_Suppl_2.108S  0.393
1996 Strong MJ, Gaytan-Garcia S. Proximal sciatic axotomy does not inhibit the induction of neurofilamentous inclusions following intracisternal aluminum chloride exposure. Journal of Neuropathology and Experimental Neurology. 55: 419-23. PMID 8786401 DOI: 10.1097/00005072-199604000-00004  0.343
1996 Strong MJ, Grace GM, Orange JB, Leeper HA. Cognition, language, and speech in amyotrophic lateral sclerosis: a review. Journal of Clinical and Experimental Neuropsychology. 18: 291-303. PMID 8780963 DOI: 10.1080/01688639608408283  0.342
1996 Chen R, Grand'Maison F, Strong MJ, Ramsay DA, Bolton CF. Motor neuron disease presenting as acute respiratory failure: a clinical and pathological study. Journal of Neurology, Neurosurgery, and Psychiatry. 60: 455-8. PMID 8774419 DOI: 10.1136/Jnnp.60.4.455  0.334
1996 Strong MJ, Garruto RM, Joshi JG, Mundy WR, Shafer TJ. Can the mechanisms of aluminum neurotoxicity be integrated into a unified scheme? Journal of Toxicology and Environmental Health. 48: 599-613. PMID 8772801 DOI: 10.1080/009841096161096  0.61
1996 Gaytan-Garcia S, Kim H, Strong MJ. Spinal motor neuron neuroaxonal spheroids in chronic aluminum neurotoxicity contain phosphatase-resistant high molecular weight neurofilament (NFH). Toxicology. 108: 17-24. PMID 8644113 DOI: 10.1016/S0300-483X(95)03266-I  0.337
1995 Strong MJ, Gaytan-Garcia S, Jakowec DM. Reversibility of neurofilamentous inclusion formation following repeated sublethal intracisternal inoculums of AlCl3 in New Zealand white rabbits. Acta Neuropathologica. 90: 57-67. PMID 7572080 DOI: 10.1007/Bf00294460  0.328
1994 Strong MJ. Aluminum neurotoxicity: an experimental approach to the induction of neurofilamentous inclusions. Journal of the Neurological Sciences. 124: 20-6. PMID 7807137 DOI: 10.1016/0022-510X(94)90172-4  0.353
1994 Strong MJ, Mao K, Nerurkar VR, Wakayama I, Yanagihara R, Garruto RM. Dose-dependent selective suppression of light (NFL) and medium (NFM) but not heavy (NFH) molecular weight neurofilament mRNA levels in acute aluminum neurotoxicity. Molecular and Cellular Neurosciences. 5: 319-26. PMID 7804601 DOI: 10.1006/Mcne.1994.1038  0.556
1993 Strong MJ, Wakayama I, Garruto RM. The neuronal cytoskeleton in disorders of late onset and slow progression. Annals of the New York Academy of Sciences. 679: 388-93. PMID 8512202 DOI: 10.1111/J.1749-6632.1993.Tb18327.X  0.56
1991 Strong MJ, Garruto RM, Wolff AV, Chou SM, Fox SD, Yanagihara R. N-butyl benzenesulfonamide: a neurotoxic plasticizer inducing a spastic myelopathy in rabbits. Acta Neuropathologica. 81: 235-41. PMID 2058361 DOI: 10.1007/Bf00305863  0.595
1991 Strong MJ, Garruto RM. Chronic aluminum-induced motor neuron degeneration: clinical, neuropathological and molecular biological aspects. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 18: 428-31. PMID 1933693 DOI: 10.1017/S0317167100032601  0.601
1991 Strong MJ, Wolff AV, Wakayama I, Garruto RM. Aluminum-induced chronic myelopathy in rabbits. Neurotoxicology. 12: 9-21. PMID 1901636  0.56
1991 Strong MJ, Garruto RM. Neuron-specific thresholds of aluminum toxicity in vitro. A comparative analysis of dissociated fetal rabbit hippocampal and motor neuron-enriched cultures. Laboratory Investigation; a Journal of Technical Methods and Pathology. 65: 243-9. PMID 1881125  0.545
1991 Garruto RM, Strong MJ, Yanagihara R. Experimental models of aluminum-induced motor neuron degeneration. Advances in Neurology. 56: 327-40. PMID 1853766  0.531
1991 Strong MJ, Garruto RM. Potentiation in the neurotoxic induction of experimental chronic neurodegenerative disorders: N-butyl benzenesulfonamide and aluminum chloride. Neurotoxicology. 12: 415-25. PMID 1745433  0.562
1990 Strong MJ, Svedmyr A, Gajdusek DC, Garruto RM. The temporal expression of amyloid precursor protein mRNA in vitro in dissociated hippocampal neuron cultures. Experimental Neurology. 109: 171-9. PMID 2116313 DOI: 10.1016/0014-4886(90)90071-Y  0.574
1989 Strong MJ, Garruto RM. Isolation of fetal mouse motor neurons on discontinuous Percoll density gradients. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 25: 939-45. PMID 2553659 DOI: 10.1007/Bf02624007  0.561
1988 Strong MJ, Brown WF, Hudson AJ, Snow R. Motor unit estimates in the biceps-brachialis in amyotrophic lateral sclerosis. Muscle & Nerve. 11: 415-22. PMID 3374513 DOI: 10.1002/Mus.880110502  0.322
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