Giulio M. Pasinetti, M.D., Ph.D. - Publications

Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY, United States 
neurodegeneration, Alzheimer's disease

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Year Citation  Score
2020 Naughton SX, Raval U, Pasinetti GM. The Viral Hypothesis in Alzheimer's Disease: Novel Insights and Pathogen-Based Biomarkers. Journal of Personalized Medicine. 10. PMID 32751069 DOI: 10.3390/Jpm10030074  0.389
2020 Iqbal UH, Zeng E, Pasinetti GM. The Use of Antimicrobial and Antiviral Drugs in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32664669 DOI: 10.3390/Ijms21144920  0.401
2020 Naughton SX, Raval U, Pasinetti GM. Potential Novel Role of COVID-19 in Alzheimer's Disease and Preventative Mitigation Strategies. Journal of Alzheimer's Disease : Jad. PMID 32538855 DOI: 10.3233/Jad-200537  0.395
2020 Ono K, Tsuji M, Yamasaki TR, Pasinetti GM. Anti-aggregation Effects of Phenolic Compounds on α-synuclein. Molecules (Basel, Switzerland). 25. PMID 32456274 DOI: 10.3390/Molecules25102444  0.347
2020 Varghese M, Zhao W, Trageser KJ, Pasinetti GM. Peroxisome Proliferator Activator Receptor Gamma Coactivator-1α Overexpression in Amyotrophic Lateral Sclerosis: A Tale of Two Transgenics. Biomolecules. 10. PMID 32414179 DOI: 10.3390/biom10050760  0.65
2020 Westfall S, Dinh DM, Pasinetti GM. Investigation of Potential Brain Microbiome in Alzheimer's Disease: Implications of Study Bias. Journal of Alzheimer's Disease : Jad. PMID 32310171 DOI: 10.3233/Jad-191328  0.44
2020 Ono K, Zhao D, Wu Q, Simon J, Wang J, Radu A, Pasinetti GM. Pine Bark Polyphenolic Extract Attenuates Amyloid-β and Tau Misfolding in a Model System of Alzheimer's Disease Neuropathology. Journal of Alzheimer's Disease : Jad. PMID 31958081 DOI: 10.3233/Jad-190543  0.419
2020 Pasinetti G. Synbiotic-Derived Metabolites Reduce Neuroinflammatory Symptoms of Alzheimer's Disease Current Developments in Nutrition. 4: 1578-1578. DOI: 10.1093/cdn/nzaa062_035  0.31
2019 Trageser KJ, Smith C, Herman FJ, Ono K, Pasinetti GM. Mechanisms of Immune Activation by Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Frontiers in Neuroscience. 13: 1298. PMID 31920478 DOI: 10.3389/Fnins.2019.01298  0.326
2019 Westfall S, Iqbal U, Sebastian M, Pasinetti GM. Gut microbiota mediated allostasis prevents stress-induced neuroinflammatory risk factors of Alzheimer's disease. Progress in Molecular Biology and Translational Science. 168: 147-181. PMID 31699313 DOI: 10.1016/Bs.Pmbts.2019.06.013  0.405
2019 Herman FJ, Simkovic S, Pasinetti GM. Neuroimmune Nexus of Depression and Dementia: Shared Mechanisms and Therapeutic Targets. British Journal of Pharmacology. PMID 30632147 DOI: 10.1111/Bph.14569  0.307
2019 Sebastian M, Frolinger T, Herman F, Pasinetti GM. TARGETING INFLAMMASOME ACTIVATION IN RESPONSE TO STRESS TO SUPPRESS ONSET AND PROGRESSION OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P1596-P1597. DOI: 10.1016/J.Jalz.2019.09.056  0.34
2018 Ho L, Zhao D, Ono K, Ruan K, Mogno I, Tsuji M, Carry E, Brathwaite J, Sims S, Frolinger T, Westfall S, Mazzola P, Wu Q, Hao K, Lloyd TE, ... ... Pasinetti GM, et al. Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity. The Journal of Nutritional Biochemistry. 64: 170-181. PMID 30530257 DOI: 10.1016/J.Jnutbio.2018.10.019  0.31
2018 Herman F, Westfall S, Brathwaite J, Pasinetti GM. Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols. Frontiers in Pharmacology. 9: 867. PMID 30210334 DOI: 10.3389/Fphar.2018.00867  0.399
2018 Frolinger T, Smith C, Cobo CF, Sims S, Brathwaite J, de Boer S, Huang J, Pasinetti GM. Dietary polyphenols promote resilience against sleep deprivation-induced cognitive impairment by activating protein translation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800030R. PMID 29702026 DOI: 10.1096/Fj.201800030R  0.33
2018 Pasinetti GM, Singh R, Westfall S, Herman F, Faith J, Ho L. The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice. Journal of Alzheimer's Disease : Jad. PMID 29660942 DOI: 10.3233/Jad-171151  0.347
2017 Ho L, Ono K, Tsuji M, Mazzola P, Singh R, Pasinetti GM. Protective Roles of Intestinal Microbiota derived Short Chain Fatty Acids in Alzheimer's Disease-type Beta-Amyloid Neuropathological Mechanisms. Expert Review of Neurotherapeutics. PMID 29095058 DOI: 10.1080/14737175.2018.1400909  0.384
2016 Ho L, Legere M, Li T, Levine S, Hao K, Valcarcel B, Pasinetti GM. Autonomic Nervous System Dysfunctions as a Basis for a Predictive Model of Risk of Neurological Disorders in Subjects with Prior History of Traumatic Brain Injury: Implications in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27911325 DOI: 10.3233/Jad-160948  0.415
2016 Ward L, Pasinetti GM. Recommendations for Development of Botanical Polyphenols as "Natural Drugs" for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment. Neuromolecular Medicine. PMID 27342633 DOI: 10.1007/S12017-016-8418-6  0.305
2016 Zhao W, Ho L, Wang J, Bi W, Yemul S, Ward L, Freire D, Mazzola P, Brathwaite J, Mezei M, Sanchez R, Elder GA, Pasinetti GM. In Silico Modelling of Novel Drug Ligands Associated with Abnormal Tau Phosphorylation: Implications for Concussion Associated Tauopathy Intervention. Journal of Cellular Biochemistry. PMID 26910498 DOI: 10.1002/Jcb.25521  0.367
2016 Wang J, Bi W, Zhao W, Varghese M, Koch RJ, Walker RH, Chandraratna RA, Sanders ME, Janesick A, Blumberg B, Ward L, Ho L, Pasinetti GM. Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease. Oncotarget. PMID 26862735 DOI: 10.18632/Oncotarget.7191  0.683
2016 Pasinetti GM. Towards prevention and therapy of Alzheimer's disease. Molecular Aspects of Medicine. 1-2. PMID 26449935 DOI: 10.1016/J.Mam.2015.09.001  0.344
2015 Dubner L, Wang J, Ho L, Ward L, Pasinetti GM. Recommendations for Development of New Standardized Forms of Cocoa Breeds and Cocoa Extract Processing for the Prevention of Alzheimer's Disease: Role of Cocoa in Promotion of Cognitive Resilience and Healthy Brain Aging. Journal of Alzheimer's Disease : Jad. PMID 26402120 DOI: 10.3233/Jad-150536  0.405
2015 Hayden EY, Yamin G, Beroukhim S, Chen B, Kibalchenko M, Jiang L, Ho L, Wang J, Pasinetti GM, Teplow DB. Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols. Journal of Neurochemistry. PMID 26228682 DOI: 10.1111/Jnc.13270  0.339
2015 Hao K, Di Narzo AF, Ho L, Luo W, Li S, Chen R, Li T, Dubner L, Pasinetti GM. Shared genetic etiology underlying alzheimer's Disease and type 2 Diabetes. Molecular Aspects of Medicine. PMID 26116273 DOI: 10.1016/J.Mam.2015.06.006  0.359
2015 Vidaurre OG, Haines JD, Sand IK, Adula KP, Huynh JL, McGraw CA, Zhang F, Varghese M, Sotirchos E, Bhargava P, Bandaru VVR, Pasinetti G, Zhang W, Inglese M, Calabresi PA, et al. Erratum: Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics (Brain (2014) 137 (2271-2286) DOI: 10.1093/brain/awu139) Brain. 138. PMID 26106099 DOI: 10.1093/Brain/Awv090  0.687
2015 Zhao W, Wang J, Varghese M, Ho L, Mazzola P, Haroutunian V, Katsel PL, Gibson GE, Levine S, Dubner L, Pasinetti GM. Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects. Neuropsychiatric Disease and Treatment. 11: 565-74. PMID 25784811 DOI: 10.2147/NDT.S74898  0.702
2015 Pasinetti GM. Novel role of red wine-derived polyphenols in the prevention of Alzheimer's disease dementia and brain pathology: experimental approaches and clinical implications. Planta Medica. PMID 25760447 DOI: 10.1055/s-0035-1545846  0.301
2015 Wang D, Ho L, Faith J, Ono K, Janle EM, Lachcik PJ, Cooper BR, Jannasch AH, D'Arcy BR, Williams BA, Ferruzzi MG, Levine S, Zhao W, Dubner L, Pasinetti GM. Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization. Molecular Nutrition & Food Research. 59: 1025-40. PMID 25689033 DOI: 10.1002/Mnfr.201400544  0.4
2015 Pasinetti GM, Wang J, Ho L, Zhao W, Dubner L. Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment. Biochimica Et Biophysica Acta. 1852: 1202-1208. PMID 25315300 DOI: 10.1016/J.Bbadis.2014.10.006  0.41
2015 Pasinetti GM. O1-11-05: Targeting multiple disease mechanisms for the treatment of Alzheimer's disease with biosynthetic polyphenol metabolites and their precursor pro-drugs in vivo Alzheimer's & Dementia. 11: P158-P158. DOI: 10.1016/J.Jalz.2015.07.091  0.347
2015 Wang J, Dickstein D, Hof P, Pasinetti GM. P2-315: Preservation of synaptic plasticity and neuronal integrity in a mouse model of Alzheimer's disease Alzheimer's & Dementia. 11: P614-P614. DOI: 10.1016/J.Jalz.2015.06.857  0.704
2015 Ho L, Faith J, Pasinetti GM. P4-155: Intestinal microbiota-derived phenol acids are capable of accumulating in the brain and interfere with β-amyloid oligomerization Alzheimer's & Dementia. 11: P838-P838. DOI: 10.1016/J.Jalz.2015.06.1862  0.317
2014 Blumberg JB, Ding EL, Dixon R, Pasinetti GM, Villarreal F. The science of cocoa flavanols: bioavailability, emerging evidence, and proposed mechanisms. Advances in Nutrition (Bethesda, Md.). 5: 547-9. PMID 25469389 DOI: 10.3945/An.114.006478  0.31
2014 Gong B, Levine S, Barnum SR, Pasinetti GM. Role of complement systems in IVIG mediated attenuation of cognitive deterioration in Alzheimer's disease. Current Alzheimer Research. 11: 637-44. PMID 25115545 DOI: 10.2174/1567205011666140812113707  0.45
2014 Wang J, Varghese M, Ono K, Yamada M, Levine S, Tzavaras N, Gong B, Hurst WJ, Blitzer RD, Pasinetti GM. Cocoa extracts reduce oligomerization of amyloid-β: implications for cognitive improvement in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 41: 643-50. PMID 24957018 DOI: 10.3233/Jad-132231  0.733
2014 Vidaurre OG, Haines JD, Katz Sand I, Adula KP, Huynh JL, McGraw CA, Zhang F, Varghese M, Sotirchos E, Bhargava P, Bandaru VV, Pasinetti G, Zhang W, Inglese M, Calabresi PA, et al. Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics. Brain : a Journal of Neurology. 137: 2271-86. PMID 24893707 DOI: 10.1093/Brain/Awu139  0.665
2014 Wang J, Bi W, Cheng A, Freire D, Vempati P, Zhao W, Gong B, Janle EM, Chen TY, Ferruzzi MG, Schmeidler J, Ho L, Pasinetti GM. Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications. Frontiers in Aging Neuroscience. 6: 42. PMID 24672477 DOI: 10.3389/Fnagi.2014.00042  0.452
2014 Wang J, Land D, Ono K, Galvez J, Zhao W, Vempati P, Steele JW, Cheng A, Yamada M, Levine S, Mazzola P, Pasinetti GM. Molecular topology as novel strategy for discovery of drugs with aβ lowering and anti-aggregation dual activities for Alzheimer's disease. Plos One. 9: e92750. PMID 24671215 DOI: 10.1371/Journal.Pone.0092750  0.378
2014 Wang J, Gong B, Zhao W, Tang C, Varghese M, Nguyen T, Bi W, Bilski A, Begum S, Vempati P, Knable L, Ho L, Pasinetti GM. Epigenetic mechanisms linking diabetes and synaptic impairments. Diabetes. 63: 645-54. PMID 24154559 DOI: 10.2337/Db13-1063  0.681
2014 Varghese M, Ho L, Wang J, Zhao W, Levine S, Ono K, Mannino S, Pasinetti GM. Green coffee as a novel agent for Alzheimer's disease prevention by attenuating diabetes Translational Neuroscience. 5: 111-116. DOI: 10.2478/S13380-014-0213-Y  0.684
2014 Wang J, Pasinetti GM. P1-408: TARGETING SYNAPTIC DYSFUNCTION THROUGH DIETARY POLYPHENOL AS A NOVEL THERAPEUTIC INTERVENTION FOR AD Alzheimer's & Dementia. 10: P463-P463. DOI: 10.1016/J.Jalz.2014.05.651  0.315
2014 Wang J, Zhao W, Freire D, Ho L, Pasinetti GM. P1-079: NOVEL ROLE OF THE DEPRESSION-ASSOCIATED GATA1 TRANSCRIPTION FACTOR IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P332-P332. DOI: 10.1016/J.Jalz.2014.05.315  0.316
2014 Ho L, Zhao W, Sanchez R, Verghese M, Freire D, Pasinetti GM. P3-060: ACTIVATION OF ECTOPICALLY EXPRESSED OLFACTORY RECEPTORS IN THE BRAIN ATTENUATES TAU-PROCESSING IN RESPONSE TO MILD TRAUMATIC BRAIN INJURY Alzheimer's & Dementia. 10: P649-P650. DOI: 10.1016/J.Jalz.2014.05.1148  0.32
2013 Wang J, Tang C, Ferruzzi MG, Gong B, Song BJ, Janle EM, Chen TY, Cooper B, Varghese M, Cheng A, Freire D, Bilski A, Roman J, Nguyen T, Ho L, ... ... Pasinetti GM, et al. Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model. Molecular Nutrition & Food Research. 57: 2091-102. PMID 23963661 DOI: 10.1002/Mnfr.201300230  0.684
2013 Gong B, Pan Y, Zhao W, Knable L, Vempati P, Begum S, Ho L, Wang J, Yemul S, Barnum S, Bilski A, Gong BY, Pasinetti GM. IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway. Molecular Immunology. 56: 619-29. PMID 23911420 DOI: 10.1016/J.Molimm.2013.06.016  0.361
2013 Wang J, Zhao Z, Lin E, Zhao W, Qian X, Freire D, Bilski AE, Cheng A, Vempati P, Ho L, Ono K, Yamada M, Pasinetti GM. Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease. Plos One. 8: e65232. PMID 23762322 DOI: 10.1371/Journal.Pone.0065232  0.353
2013 Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GM. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Neurobiology of Aging. 34: 1581-8. PMID 23312803 DOI: 10.1016/J.Neurobiolaging.2012.12.005  0.428
2013 Zhao W, Ho L, Varghese M, Yemul S, Dams-O'Connor K, Gordon W, Knable L, Freire D, Haroutunian V, Pasinetti GM. Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy. Journal of Alzheimer's Disease : Jad. 34: 417-29. PMID 23241557 DOI: 10.3233/Jad-121894  0.688
2013 Wang J, Wright HM, Vempati P, Li H, Wangsa J, Dzhuan A, Habbu K, Knable LA, Ho L, Pasinetti GM. Investigation of nebivolol as a novel therapeutic agent for the treatment of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: 1147-56. PMID 23128558 DOI: 10.3233/Jad-2012-120904  0.46
2013 Ho L, Ferruzzi MG, Janle EM, Wang J, Gong B, Chen TY, Lobo J, Cooper B, Wu QL, Talcott ST, Percival SS, Simon JE, Pasinetti GM. Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 769-81. PMID 23097297 DOI: 10.1096/Fj.12-212118  0.444
2013 Pasinetti G. IRX4204 As a novel disease-modifying compound for treatment of Parkinson'/INS;s disease Journal of the Neurological Sciences. 333: e78. DOI: 10.1016/J.Jns.2013.07.548  0.304
2012 Zhao W, Varghese M, Vempati P, Dzhun A, Cheng A, Wang J, Lange D, Bilski A, Faravelli I, Pasinetti GM. Caprylic triglyceride as a novel therapeutic approach to effectively improve the performance and attenuate the symptoms due to the motor neuron loss in ALS disease. Plos One. 7: e49191. PMID 23145119 DOI: 10.1371/Journal.Pone.0049191  0.674
2012 Pasinetti GM. Novel role of red wine-derived polyphenols in the prevention of Alzheimer's disease dementia and brain pathology: experimental approaches and clinical implications. Planta Medica. 78: 1614-9. PMID 23023952 DOI: 10.1055/S-0032-1315377  0.455
2012 Ho L, Yemul S, Knable L, Katsel P, Zhao R, Haroutunian V, Pasinetti GM. Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases. International Journal of Alzheimer's Disease. 2012: 321280. PMID 22666619 DOI: 10.1155/2012/321280  0.402
2012 Ho L, Zhao W, Dams-O'Connor K, Tang CY, Gordon W, Peskind ER, Yemul S, Haroutunian V, Pasinetti GM. Elevated plasma MCP-1 concentration following traumatic brain injury as a potential "predisposition" factor associated with an increased risk for subsequent development of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: 301-13. PMID 22543850 DOI: 10.3233/Jad-2012-120598  0.351
2012 Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda GA, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon JE, Zhang C, ... ... Pasinetti GM, et al. Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5144-50. PMID 22496560 DOI: 10.1523/Jneurosci.6437-11.2012  0.412
2012 Santa-Maria I, Varghese M, Ksiezak-Reding H, Dzhun A, Wang J, Pasinetti GM. Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes. The Journal of Biological Chemistry. 287: 20522-33. PMID 22496370 DOI: 10.1074/Jbc.M111.323279  0.719
2012 Ho L, Varghese M, Wang J, Zhao W, Chen F, Knable LA, Ferruzzi M, Pasinetti GM. Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice. Nutritional Neuroscience. 15: 37-45. PMID 22305652 DOI: 10.1179/1476830511Y.0000000027  0.705
2012 Santa-Maria I, Diaz-Ruiz C, Ksiezak-Reding H, Chen A, Ho L, Wang J, Pasinetti GM. GSPE interferes with tau aggregation in vivo: implication for treating tauopathy. Neurobiology of Aging. 33: 2072-81. PMID 22054871 DOI: 10.1016/J.Neurobiolaging.2011.09.027  0.373
2012 Ksiezak-Reding H, Ho L, Santa-Maria I, Diaz-Ruiz C, Wang J, Pasinetti GM. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiology of Aging. 33: 1427-39. PMID 21196065 DOI: 10.1016/J.Neurobiolaging.2010.11.006  0.395
2012 Pasinetti G, Ono K, Wang J. Development of Carvedilol Analogs with Anti-Oligomerization Activity for Treating AD (P04.191) Neurology. 78: P04.191-P04.191. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P04.191  0.408
2012 Varghese M, Wang J, Cheng A, Ho L, Tang C, Pasinetti G. O2-09-05: Epigenetic modification in metabolic syndrome-induced brain energy impairment Alzheimer's & Dementia. 8: P253-P253. DOI: 10.1016/J.Jalz.2012.05.676  0.667
2012 Pasinetti G. Paired helical filaments from Alzheimer's disease brains induce the intracellular accumulation of tau in aggresomes: Novel therapeutic approaches to prevent the propagation and spreading of tau pathology Alzheimers & Dementia. 8: 98. DOI: 10.1016/J.Jalz.2012.05.243  0.421
2012 Gong B, Wang J, Pasinetti G. P3-050: Epigenetic mechanisms underlying the risk of Alzheimer's disease among diabetic subjects Alzheimer's & Dementia. 8: P472-P472. DOI: 10.1016/J.Jalz.2012.05.2157  0.322
2012 Pasinetti GM, Rosenberg P. 61 Repurposing anti-hypertensive drugs for Alzheimer's disease Neurobiology of Aging. 33: S26-S27. DOI: 10.1016/J.Jalz.2012.05.1912  0.326
2012 Gong B, Yong P, Knable L, Vempati P, Ho L, Wang J, Pasinetti G. P4-047: Nicotinamide riboside promotes cognitive function and synaptic plasticity in an Alzheimer's mouse model through up regulation of PGC-1a-mediated BACE1 degradation Alzheimer's & Dementia. 8: P651-P652. DOI: 10.1016/J.Jalz.2012.05.1748  0.32
2012 Knable L, Vempati P, Freire D, Ferruzzi M, Pasinetti G. Intranasal delivery of bioactive polyphenol metabolites to prevent and/or treat Alzheimer's disease and other forms of dementia Alzheimers & Dementia. 8: 577. DOI: 10.1016/J.Jalz.2012.05.1566  0.384
2012 Zhao W, Varghese M, Ho L, Dams-O'Connor K, Gordon W, Pasinetti G. P3-029: Role of olfactory receptors in traumatic brain injury-associated tauopathy Alzheimer's & Dementia. 8: P464-P464. DOI: 10.1016/J.Jalz.2012.05.1247  0.688
2011 Varghese M, Zhao W, Wang J, Cheng A, Qian X, Chaudhry A, Ho L, Pasinetti GM. Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice. Translational Neuroscience. 2. PMID 24286008 DOI: 10.2478/S13380-011-0011-8  0.716
2011 Pasinetti GM, Wang J, Marambaud P, Ferruzzi M, Gregor P, Knable LA, Ho L. Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders. Experimental Neurology. 232: 1-6. PMID 21907197 DOI: 10.1016/J.Expneurol.2011.08.014  0.325
2011 Pasinetti GM, Wang J, Porter S, Ho L. Caloric intake, dietary lifestyles, macronutrient composition, and alzheimer' disease dementia. International Journal of Alzheimer's Disease. 2011: 806293. PMID 21808725 DOI: 10.4061/2011/806293  0.384
2011 Zhao W, Varghese M, Yemul S, Pan Y, Cheng A, Marano P, Hassan S, Vempati P, Chen F, Qian X, Pasinetti GM. Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis. Molecular Neurodegeneration. 6: 51. PMID 21771318 DOI: 10.1186/1750-1326-6-51  0.669
2011 Liu P, Kemper LJ, Wang J, Zahs KR, Ashe KH, Pasinetti GM. Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 mice. Journal of Alzheimer's Disease : Jad. 26: 657-66. PMID 21743132 DOI: 10.3233/Jad-2011-110383  0.431
2011 Wang J, Ferruzzi MG, Varghese M, Qian X, Cheng A, Xie M, Zhao W, Ho L, Pasinetti GM. Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease. Molecular Neurodegeneration. 6: 7. PMID 21247479 DOI: 10.1186/1750-1326-6-7  0.745
2011 Wang J, Ono K, Dickstein DL, Arrieta-Cruz I, Zhao W, Qian X, Lamparello A, Subnani R, Ferruzzi M, Pavlides C, Ho L, Hof PR, Teplow DB, Pasinetti GM. Carvedilol as a potential novel agent for the treatment of Alzheimer's disease. Neurobiology of Aging. 32: 2321.e1-12. PMID 20579773 DOI: 10.1016/J.Neurobiolaging.2010.05.004  0.744
2011 Pasinetti G, Land D, Galvez J, Wang J. Application of molecular topology in Alzheimer's disease drug discovery Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.09.128  0.328
2011 Pasinetti G. P3-485: Complement components C5-derived C5a anaphylatoxin-mediated attenuation of cognitive deterioration is a potential novel pharmacological target of IVIG regulated hormonal immunotherapy in Alzheimer's disease Alzheimer's & Dementia. 7: S670-S670. DOI: 10.1016/J.Jalz.2011.05.1930  0.331
2011 Wang J, Land D, Galvez J, Pasinetti G. From in silico to in vitro to in vivo: - Novel approach in Alzheimer's disease drug discovery Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1382  0.337
2011 Ho L, Bloom P, Vega J, Yemul S, Zhao W, Pasinetti G. Mindfulness-based stress reduction for caregivers of patients with Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1245  0.33
2011 Pasinetti G. Poster 123 Traumatic Brain Injuries as a Risk Factor for Alzheimer's Disease Archives of Physical Medicine and Rehabilitation. 92: 1727. DOI: 10.1016/J.Apmr.2011.07.149  0.353
2010 Wang J, Pfleger CM, Friedman L, Vittorino R, Zhao W, Qian X, Conley L, Ho L, Pasinetti GM. POTENTIAL APPLICATION OF GRAPE DERIVED POLYPHENOLS IN HUNTINGTON'S DISEASE. Translational Neuroscience. 1: 95-100. PMID 21331299 DOI: 10.2478/V10134-010-0022-Y  0.376
2010 Pasinetti GM, Fivecoat H, Ho L. Personalized medicine in traumatic brain injury. The Psychiatric Clinics of North America. 33: 905-13. PMID 21093685 DOI: 10.1016/J.Psc.2010.09.003  0.314
2010 Wang J, Santa-Maria I, Ho L, Ksiezak-Reding H, Ono K, Teplow DB, Pasinetti GM. Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 22: 653-61. PMID 20858961 DOI: 10.3233/Jad-2010-101074  0.446
2010 Gong B, Chen F, Pan Y, Arrieta-Cruz I, Yoshida Y, Haroutunian V, Pasinetti GM. SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function. Aging Cell. 9: 1018-31. PMID 20854419 DOI: 10.1111/J.1474-9726.2010.00632.X  0.468
2010 Ho L, Pasinetti GM. Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding. Expert Review of Proteomics. 7: 579-89. PMID 20653511 DOI: 10.1586/Epr.10.69  0.386
2010 Bartolomucci A, Pasinetti GM, Salton SR. Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders. Neuroscience. 170: 289-97. PMID 20600637 DOI: 10.1016/J.Neuroscience.2010.06.057  0.361
2010 Arrieta-Cruz I, Wang J, Pavlides C, Pasinetti GM. Carvedilol reestablishes long-term potentiation in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 21: 649-54. PMID 20571219 DOI: 10.3233/Jad-2010-100225  0.305
2010 Pasinetti GM, Ksiezak-Reding H, Santa-Maria I, Wang J, Ho L. Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. Journal of Neurochemistry. 114: 1557-68. PMID 20569300 DOI: 10.1111/J.1471-4159.2010.06875.X  0.429
2010 Wang J, Fivecoat H, Ho L, Pan Y, Ling E, Pasinetti GM. The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology. Biochimica Et Biophysica Acta. 1804: 1690-4. PMID 19945548 DOI: 10.1016/J.Bbapap.2009.11.015  0.632
2010 Ho L, Fivecoat H, Wang J, Pasinetti GM. Alzheimer's disease biomarker discovery in symptomatic and asymptomatic patients: experimental approaches and future clinical applications. Experimental Gerontology. 45: 15-22. PMID 19796674 DOI: 10.1016/J.Exger.2009.09.007  0.417
2010 Arrieta-Cruz I, Pavlides C, Pasinetti GM. Deep brain stimulation facilitates memory in a model of alzheimer's disease Translational Neuroscience. 1: 170-176. DOI: 10.2478/V10134-010-0026-7  0.346
2010 Pasinetti GM, Ho L, Wright HM, Wang J. P4-120: Nebivolol, a Cardioselective β1 Adrenergic Receptor Blocker, Promotes Clearance of Amyloidogenic aβ Peptides from the Brain in Tg2576 Ad Mice. Alzheimer's & Dementia. 6: e58-e58. DOI: 10.1016/J.Jalz.2010.08.179  0.365
2010 Ho L, Zhao W, Pasinetti GM. P2-444: Energy Metabolism Deficit in the Brain May Contribute to Increasing Susceptibility of Oldest Olds to Alzheimer's Disease Dementia Alzheimer's & Dementia. 6: e6-e6. DOI: 10.1016/J.Jalz.2010.08.018  0.401
2010 Gong B, Chen F, Pan Y, Arrieta-cruz I, Yoshida Y, Haroutunian V, Pasinetti GM. P3-418: Fbx2-E3 ligase mediated degradation of BACE1 attenuates Alzheimer amyloidosis and improve synaptic function Alzheimer's & Dementia. 6: S575-S575. DOI: 10.1016/J.Jalz.2010.05.1961  0.306
2010 Liu P, Kotilinek LA, Kemper LJ, Wang J, Zahs KR, Ashe KH, Pasinetti GM. Grape seed polyphenolic extract specifically decreases Aβ∗56 in the brains of Tg2576 mice Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1792  0.431
2010 Ling E, Shrikhande RA, Pasinetti GM. Neurotransmitters and growth factors: Overview Encyclopedia of Neuroscience. 1073-1083. DOI: 10.1016/B978-008045046-9.00139-X  0.439
2009 Díaz-Ruiz C, Wang J, Ksiezak-Reding H, Ho L, Qian X, Humala N, Thomas S, Martínez-Martín P, Pasinetti GM. Role of Hypertension in Aggravating Abeta Neuropathology of AD Type and Tau-Mediated Motor Impairment. Cardiovascular Psychiatry and Neurology. 2009: 107286. PMID 19936102 DOI: 10.1155/2009/107286  0.394
2009 Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S. Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration. 4: 40. PMID 19845940 DOI: 10.1186/1750-1326-4-40  0.739
2009 Ferruzzi MG, Lobo JK, Janle EM, Cooper B, Simon JE, Wu QL, Welch C, Ho L, Weaver C, Pasinetti GM. Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 18: 113-24. PMID 19625746 DOI: 10.3233/Jad-2009-1135  0.325
2009 Qin W, Haroutunian V, Katsel P, Cardozo CP, Ho L, Buxbaum JD, Pasinetti GM. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Archives of Neurology. 66: 352-61. PMID 19273754 DOI: 10.1001/Archneurol.2008.588  0.39
2009 Ho L, Yemul S, Wang J, Pasinetti GM. Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies. Journal of Alzheimer's Disease : Jad. 16: 433-9. PMID 19221432 DOI: 10.3233/Jad-2009-0969  0.363
2009 Amadio M, Pascale A, Wang J, Ho L, Quattrone A, Gandy S, Haroutunian V, Racchi M, Pasinetti GM. nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing. Journal of Alzheimer's Disease : Jad. 16: 409-19. PMID 19221430 DOI: 10.3233/Jad-2009-0967  0.414
2009 Qin W, Ho L, Wang J, Peskind E, Pasinetti GM. S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10. Plos One. 4: e4183. PMID 19159013 DOI: 10.1371/Journal.Pone.0004183  0.445
2009 Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow D, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Dickstein DL, Pasinetti GM. Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration. Journal of Alzheimer's Disease : Jad. 16: 59-72. PMID 19158422 DOI: 10.3233/Jad-2009-0916  0.702
2009 Zhao W, Wang J, Ho L, Ono K, Teplow DB, Pasinetti GM. Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization. Journal of Alzheimer's Disease : Jad. 16: 49-57. PMID 19158421 DOI: 10.3233/Jad-2009-0925  0.387
2009 Pasinetti G, Rosen Z, Grossman H. P4-331: Nic5-15: a novel natural gamma-secretase inhibitor that attenuates brain beta-amyloid content and improves cognition Alzheimer's & Dementia. 5: e28-e28. DOI: 10.1016/J.Jalz.2009.07.110  0.335
2009 Pasinetti G, Rosen Z, Rosenberg P, Wang J. Carvedilol as a Potential Novel Disease Modifying Agent for the Treatment of Alzheimer's Disease Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.07.109  0.351
2009 Wang J, Zhao W, Ho L, Qian X, Arrieta-Cruz I, Ono K, Teplow D, Pasinetti GM. P3-287: Carvedilol reduces Aβ oligomerization and improves spatial memory in mouse models of Alzheimer's disease Alzheimer's & Dementia. 5: P427-P427. DOI: 10.1016/J.Jalz.2009.04.958  0.356
2008 Qin W, Zhao W, Ho L, Wang J, Walsh K, Gandy S, Pasinetti GM. Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration. Annals of the New York Academy of Sciences. 1147: 335-47. PMID 19076455 DOI: 10.1196/Annals.1427.024  0.407
2008 Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM, Teplow DB. Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. The Journal of Biological Chemistry. 283: 32176-87. PMID 18815129 DOI: 10.1074/Jbc.M806154200  0.377
2008 Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB, Pasinetti GM. Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6388-92. PMID 18562609 DOI: 10.1523/Jneurosci.0364-08.2008  0.435
2008 Pasinetti GM, Eberstein JA. Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease. Journal of Neurochemistry. 106: 1503-14. PMID 18466323 DOI: 10.1111/J.1471-4159.2008.05454.X  0.37
2007 Wang J, Ho L, Chen L, Zhao Z, Zhao W, Qian X, Humala N, Seror I, Bartholomew S, Rosendorff C, Pasinetti GM. Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 117: 3393-402. PMID 17965777 DOI: 10.1172/Jci31547  0.434
2007 Pasinetti GM, Zhao Z, Qin W, Ho L, Shrishailam Y, Macgrogan D, Ressmann W, Humala N, Liu X, Romero C, Stetka B, Chen L, Ksiezak-Reding H, Wang J. Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications. Interdisciplinary Topics in Gerontology. 35: 159-75. PMID 17063038 DOI: 10.1159/000096561  0.308
2007 Zhao Z, Xiang Z, Haroutunian V, Buxbaum JD, Stetka B, Pasinetti GM. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiology of Aging. 28: 824-30. PMID 16769157 DOI: 10.1016/J.Neurobiolaging.2006.05.001  0.399
2007 Pasinetti GM. S3-01-02: Lifestyle factors and Alzheimer's disease: Experimental approaches and clinical implications Alzheimer's & Dementia. 3: S198-S198. DOI: 10.1016/J.Jalz.2007.04.009  0.332
2006 Qin W, Chachich M, Lane M, Roth G, Bryant M, de Cabo R, Ottinger MA, Mattison J, Ingram D, Gandy S, Pasinetti GM. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). Journal of Alzheimer's Disease : Jad. 10: 417-22. PMID 17183154 DOI: 10.3233/Jad-2006-10411  0.406
2006 Takahashi M, Uchikado H, Caprotti D, Weidenheim KM, Dickson DW, Ksiezak-Reding H, Pasinetti GM. Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles. Journal of Neuropathology and Experimental Neurology. 65: 1157-69. PMID 17146290 DOI: 10.1097/01.Jnen.0000248542.82681.12  0.385
2006 Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, Thiyagarajan M, Percival SS, Talcott ST, Pasinetti GM. Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2313-20. PMID 17077308 DOI: 10.1096/Fj.06-6281Com  0.697
2006 Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, ... ... Pasinetti GM, et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. The Journal of Biological Chemistry. 281: 21745-54. PMID 16751189 DOI: 10.1074/Jbc.M602909200  0.445
2006 Zhao Z, Lange DJ, Voustianiouk A, MacGrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM. A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. Bmc Neuroscience. 7: 29. PMID 16584562 DOI: 10.1186/1471-2202-7-29  0.316
2006 Ho L, Qin W, Stetka BS, Pasinetti GM. Is there a future for cyclo-oxygenase inhibitors in Alzheimer's disease? Cns Drugs. 20: 85-98. PMID 16478285 DOI: 10.2165/00023210-200620020-00001  0.41
2006 Xiang Z, Haroutunian V, Ho L, Purohit D, Pasinetti GM. Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia. Disease Markers. 22: 95-102. PMID 16410654 DOI: 10.1155/2006/276239  0.376
2006 Qin W, Peng Y, Ksiezak-Reding H, Ho L, Stetka B, Lovati E, Pasinetti GM. Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease. Molecular Psychiatry. 11: 172-81. PMID 16331303 DOI: 10.1038/Sj.Mp.4001773  0.363
2006 Pasinetti GM. P1-023: Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer’s disease amyloid neuropathology by calorie restriction Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.398  0.372
2006 Pasinetti GM. P1-012: Alzheimer's disease type neuropathology and spatial memory deterioration is attenuated by cabernet sauvignon consumption in the Tg2576 mouse model Alzheimer's & Dementia. 2: S97-S97. DOI: 10.1016/J.Jalz.2006.05.387  0.332
2005 Zhao Z, Ho L, Wang J, Qin W, Festa ED, Mobbs C, Hof P, Rocher A, Masur S, Haroutunian V, Pasinetti GM. Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2081-2. PMID 16186174 DOI: 10.1096/Fj.05-4359Fje  0.558
2005 Ho L, Sharma N, Blackman L, Festa E, Reddy G, Pasinetti GM. From proteomics to biomarker discovery in Alzheimer's disease. Brain Research. Brain Research Reviews. 48: 360-9. PMID 15850675 DOI: 10.1016/J.Brainresrev.2004.12.025  0.446
2005 Zhao Z, Ksiezak-Reding H, Wang J, Pasinetti GM. Expression of tau reduces secretion of Abeta without altering the amyloid precursor protein content in CHOsw cells. Febs Letters. 579: 2119-24. PMID 15811328 DOI: 10.1016/J.Febslet.2005.02.067  0.379
2005 Wang J, Ho L, Qin W, Rocher AB, Seror I, Humala N, Maniar K, Dolios G, Wang R, Hof PR, Pasinetti GM. Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 659-61. PMID 15650008 DOI: 10.1096/Fj.04-3182Fje  0.558
2005 Wang J, Ho L, Pasinetti GM. [O2-03-03]: Low carbohydrate dietary intake prevents amyloid neuropathology in a mouse model of Alzheimer's disease Alzheimer's & Dementia. 1: S99-S99. DOI: 10.1016/J.Jalz.2005.06.344  0.377
2005 Wang J, Ho L, Pasinetti GM. [P-167]: The Development of NIC5-15, a natural anti-diabetic agent, in the treatment of Alzheimer's disease Alzheimer's & Dementia. 1: S62-S62. DOI: 10.1016/J.Jalz.2005.06.228  0.323
2005 Qin W, Ho L, Pasinetti GM. [P-008]: The development of psoriasin as a novel therapeutic agent in Alzheimer's disease Alzheimer's & Dementia. 1: S11-S11. DOI: 10.1016/J.Jalz.2005.06.070  0.349
2004 Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 902-4. PMID 15033922 DOI: 10.1096/Fj.03-0978Fje  0.52
2004 Ho L, Pasinetti GM. P1-164 Psoriasin a novel Alzheimer's disease biomarker with anti-amyloidogenic activity Neurobiology of Aging. 25: S142. DOI: 10.1016/S0197-4580(04)80477-9  0.358
2004 Wang J, Pasinetti GM. O2-04-03 Insulin resistance promotes β amyloid peptide generation in the brain of a mouse model of Alzheimer's disease Neurobiology of Aging. 25: S39. DOI: 10.1016/S0197-4580(04)80129-5  0.359
2003 Ksiezak-Reding H, Pyo HK, Feinstein B, Pasinetti GM. Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro. Biochimica Et Biophysica Acta. 1639: 159-68. PMID 14636947 DOI: 10.1016/J.Bbadis.2003.09.001  0.305
2003 Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. The Journal of Biological Chemistry. 278: 50970-7. PMID 14507922 DOI: 10.1074/Jbc.M307699200  0.31
2003 Pompl PN, Yemul S, Xiang Z, Ho L, Haroutunian V, Purohit D, Mohs R, Pasinetti GM. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Archives of Neurology. 60: 369-76. PMID 12633148 DOI: 10.1001/Archneur.60.3.369  0.388
2002 Pasinetti GM, Pompl PN. Cyclo-oxygenase inhibitors and Alzheimer's: are we well ADAPTed? The Lancet. Neurology. 1: 403-4. PMID 12849357 DOI: 10.1016/S1474-4422(02)00214-4  0.322
2002 Pasinetti GM. Cyclooxygenase as a target for the antiamyloidogenic activities of nonsteroidal anti-inflammatory drugs in Alzheimer's disease. Neuro-Signals. 11: 293-7. PMID 12566930 DOI: 10.1159/000067428  0.375
2002 Xiang Z, Ho L, Yemul S, Zhao Z, Qing W, Pompl P, Kelley K, Dang A, Qing W, Teplow D, Pasinetti GM. Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. Gene Expression. 10: 271-8. PMID 12450219  0.323
2002 Pasinetti GM. From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in beta-amyloidosis and clinical dementia. Journal of Alzheimer's Disease : Jad. 4: 435-45. PMID 12446975 DOI: 10.3233/Jad-2002-4510  0.405
2002 Pasinetti GM, Ho L, Pompl P. Amyloid immunization in Alzheimer's disease: do we promote amyloid scavenging at the cost of inflammatory degeneration? Neurobiology of Aging. 23: 665-6. PMID 12392767 DOI: 10.1016/S0197-4580(02)00007-6  0.397
2002 Butterfield DA, Griffin S, Munch G, Pasinetti GM. Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists. Journal of Alzheimer's Disease : Jad. 4: 193-201. PMID 12226538 DOI: 10.3233/Jad-2002-4309  0.398
2002 Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiology of Disease. 10: 8-19. PMID 12079399 DOI: 10.1006/Nbdi.2002.0490  0.464
2002 Mirjany M, Ho L, Pasinetti GM. Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity. The Journal of Pharmacology and Experimental Therapeutics. 301: 494-500. PMID 11961048 DOI: 10.1124/Jpet.301.2.494  0.348
2002 Xiang Z, Ho L, Valdellon J, Borchelt D, Kelley K, Spielman L, Aisen PS, Pasinetti GM. Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiology of Aging. 23: 327-34. PMID 11959394 DOI: 10.1016/S0197-4580(01)00282-2  0.42
2002 Aisen PS, Schmeidler J, Pasinetti GM. Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology. 58: 1050-4. PMID 11940691 DOI: 10.1212/Wnl.58.7.1050  0.327
2002 Spielman L, Winger D, Ho L, Aisen PS, Shohami E, Pasinetti GM. Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Acta Neuropathologica. 103: 157-62. PMID 11810182 DOI: 10.1007/S004010100447  0.407
2002 Pasinetti GM, Ho L, Pompl P. AN1792 vaccination immunotherapy in Alzheimer's disease: The case of a therapy before its time Neurobiology of Aging. 23: 683-684. DOI: 10.1016/S0197-4580(02)00081-7  0.331
2002 Pasinetti GM. From cyclooxygenase activities to Alzheimer's disease neuropathology: Experimental approaches and therapeutic interventions Drug Development Research. 56: 438-445. DOI: 10.1002/Ddr.10096  0.406
2001 Pasinetti GM, Ho L. From cDNA microarrays to high-throughput proteomics. Implications in the search for preventive initiatives to slow the clinical progression of Alzheimer's disease dementia. Restorative Neurology and Neuroscience. 18: 137-42. PMID 11847436  0.326
2001 Pasinetti GM. Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia. Journal of Neuroscience Research. 65: 471-6. PMID 11550214 DOI: 10.1002/Jnr.1176  0.415
2001 Ho L, Xiang Z, Mukherjee P, Zhang W, De Jesus N, Mirjany M, Yemul S, Pasinetti GM. Gene expression profiling of the tau mutant (P301L) transgenic mouse brain. Neuroscience Letters. 310: 1-4. PMID 11524143 DOI: 10.1016/S0304-3940(01)02044-4  0.333
2001 Pasinetti GM. Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia. Archives of Gerontology and Geriatrics. 33: 13-28. PMID 11461718 DOI: 10.1016/S0167-4943(01)00091-7  0.366
2001 Ho L, Purohit D, Haroutunian V, Luterman JD, Willis F, Naslund J, Buxbaum JD, Mohs RC, Aisen PS, Pasinetti GM. Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Archives of Neurology. 58: 487-92. PMID 11255454 DOI: 10.1001/Archneur.58.3.487  0.44
2001 Ho L, Guo Y, Spielman L, Petrescu O, Haroutunian V, Purohit D, Czernik A, Yemul S, Aisen PS, Mohs R, Pasinetti GM. Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique. Neuroscience Letters. 298: 191-4. PMID 11165439 DOI: 10.1016/S0304-3940(00)01753-5  0.38
2000 Hull M, Pasinetti GM, Aisen PS. Elevated plasma neopterin levels in Alzheimer disease. Alzheimer Disease and Associated Disorders. 14: 228-30. PMID 11186601 DOI: 10.1097/00002093-200010000-00007  0.332
2000 Luterman JD, Haroutunian V, Yemul S, Ho L, Purohit D, Aisen PS, Mohs R, Pasinetti GM. Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia. Archives of Neurology. 57: 1153-60. PMID 10927795 DOI: 10.1001/Archneur.57.8.1153  0.377
2000 Mukherjee P, Pasinetti GM. The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease. Journal of Neuroimmunology. 105: 124-30. PMID 10742554 DOI: 10.1016/S0165-5728(99)00261-1  0.368
2000 Pasinetti GM. The role of inflammation in the clinical progression of Alzheimer's disease dementia Neurobiology of Aging. 21: 286. DOI: 10.1016/S0197-4580(00)83237-6  0.376
1999 Battaini F, Pascale A, Lucchi L, Pasinetti GM, Govoni S. Protein kinase C anchoring deficit in postmortem brains of Alzheimer's disease patients. Experimental Neurology. 159: 559-64. PMID 10506528 DOI: 10.1006/Exnr.1999.7151  0.408
1999 Kelley KA, Ho L, Winger D, Freire-Moar J, Borelli CB, Aisen PS, Pasinetti GM. Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. The American Journal of Pathology. 155: 995-1004. PMID 10487857 DOI: 10.1016/S0002-9440(10)65199-1  0.322
1999 Ho L, Pieroni C, Winger D, Purohit DP, Aisen PS, Pasinetti GM. Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease. Journal of Neuroscience Research. 57: 295-303. PMID 10412020 DOI: 10.1002/(Sici)1097-4547(19990801)57:3<295::Aid-Jnr1>3.0.Co;2-0  0.425
1999 Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Experimental Neurology. 157: 194-201. PMID 10222122 DOI: 10.1006/Exnr.1999.7052  0.313
1998 Aisen PS, Luddy A, Durner M, Reinhard JF, Pasinetti GM. HLA-DR4 influences glial activity in Alzheimer's disease hippocampus. Journal of the Neurological Sciences. 161: 66-9. PMID 9879683 DOI: 10.1016/S0022-510X(98)00268-8  0.345
1998 Pasinetti GM. Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions. Journal of Neuroscience Research. 54: 1-6. PMID 9778144 DOI: 10.1002/(Sici)1097-4547(19981001)54:1<1::Aid-Jnr1>3.0.Co;2-M  0.412
1998 Pasinetti GM, Aisen PS. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience. 87: 319-24. PMID 9740394 DOI: 10.1016/S0306-4522(98)00218-8  0.41
1998 Aisen PS, Pasinetti GM. Glucocorticoids in Alzheimer's disease. The story so far. Drugs & Aging. 12: 1-6. PMID 9467682 DOI: 10.2165/00002512-199812010-00001  0.35
1997 Tocco G, Freire-Moar J, Schreiber SS, Sakhi SH, Aisen PS, Pasinetti GM. Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease. Experimental Neurology. 144: 339-49. PMID 9168834 DOI: 10.1006/Exnr.1997.6429  0.351
1996 Pasinetti GM, Tocco G, Sakhi S, Musleh WD, DeSimoni MG, Mascarucci P, Schreiber S, Baudry M, Finch CE. Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions. Neurobiology of Disease. 3: 197-204. PMID 8980020 DOI: 10.1006/Nbdi.1996.0020  0.304
1996 Pasinetti GM. Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: the role of the complement system. Neurobiology of Aging. 17: 707-16. PMID 8892343 DOI: 10.1016/0197-4580(96)00113-3  0.416
1996 De Simoni M, Mascarucci P, Tocco G, Finch C, Pasinetti G. 739 Inflammation and Alzheimer's disease. The role of the complement derived anaphylatoxin C5a Neurobiology of Aging. 17: S183-S184. DOI: 10.1016/S0197-4580(96)80741-X  0.329
1996 Pasinetti G, Mall N, Shioi J, Tezapsidis N, Li H, Robakis N. 550 Expression of Presenilin 1 (PS-1; S182) in response to experimental lesion models of Alzheimer disease Neurobiology of Aging. 17: S137. DOI: 10.1016/S0197-4580(96)80552-5  0.333
1995 Bertrand P, Poirier J, Oda T, Finch CE, Pasinetti GM. Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease. Brain Research. Molecular Brain Research. 33: 174-8. PMID 8774959 DOI: 10.1016/0169-328X(95)00097-C  0.387
1995 Oda T, Wals P, Osterburg HH, Johnson SA, Pasinetti GM, Morgan TE, Rozovsky I, Stine WB, Snyder SW, Holzman TF. Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress. Experimental Neurology. 136: 22-31. PMID 7589331 DOI: 10.1006/Exnr.1995.1080  0.315
1994 Pasinetti GM, Johnson SA, Oda T, Rozovsky I, Finch CE. Clusterin (SGP-2): a multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain. The Journal of Comparative Neurology. 339: 387-400. PMID 8132868 DOI: 10.1002/Cne.903390307  0.314
1994 Oda T, Pasinetti GM, Osterburg HH, Anderson C, Johnson SA, Finch CE. Purification and characterization of brain clusterin. Biochemical and Biophysical Research Communications. 204: 1131-6. PMID 7980587 DOI: 10.1006/Bbrc.1994.2580  0.387
1994 Rozovsky I, Morgan TE, Willoughby DA, Dugichi-Djordjevich MM, Pasinetti GM, Johnson SA, Finch CE. Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro. Neuroscience. 62: 741-58. PMID 7870303 DOI: 10.1016/0306-4522(94)90473-1  0.303
1994 Cheng HW, Jiang T, Brown SA, Pasinetti GM, Finch CE, McNeill TH. Response of striatal astrocytes to neuronal deafferentation: an immunocytochemical and ultrastructural study. Neuroscience. 62: 425-39. PMID 7830889 DOI: 10.1016/0306-4522(94)90377-8  0.307
1993 Finch CE, Laping NJ, Morgan TE, Nichols NR, Pasinetti GM. TGF-beta 1 is an organizer of responses to neurodegeneration. Journal of Cellular Biochemistry. 53: 314-22. PMID 8300749 DOI: 10.1002/Jcb.240530408  0.309
1992 Pasinetti GM, Johnson SA, Rozovsky I, Lampert-Etchells M, Morgan DG, Gordon MN, Morgan TE, Willoughby D, Finch CE. Complement C1qB and C4 mRNAs responses to lesioning in rat brain. Experimental Neurology. 118: 117-25. PMID 1426121 DOI: 10.1016/0014-4886(92)90028-O  0.309
1992 Johnson SA, Lampert-Etchells M, Pasinetti GM, Rozovsky I, Finch CE. Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning. Neurobiology of Aging. 13: 641-8. PMID 1362796 DOI: 10.1016/0197-4580(92)90086-D  0.383
1991 Pasinetti GM, Cheng HW, Reinhard JF, Finch CE, McNeill TH. Molecular and morphological correlates following neuronal deafferentation: a cortico-striatal model. Advances in Experimental Medicine and Biology. 296: 249-55. PMID 1781331 DOI: 10.1007/978-1-4684-8047-4_23  0.319
1988 Johnson SA, Pasinetti GM, May PC, Ponte PA, Cordell B, Finch CE. Selective reduction of mRNA for the beta-amyloid precursor protein that lacks a Kunitz-type protease inhibitor motif in cortex from Alzheimer brains. Experimental Neurology. 102: 264-8. PMID 2460367 DOI: 10.1016/0014-4886(88)90104-5  0.394
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