Nikolaos K. Robakis - Publications

Affiliations: 
Icahn School of Medicine at Mount Sinai, New York, NY, United States 

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Høilund-Carlsen PF, Alavi A, Barrio JR, Castellani RJ, Costa T, Herrup K, Kepp KP, Neve RL, Perry G, Revheim ME, Robakis NK, Sensi SL, Vissel B. Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village. Ageing Research Reviews. 93: 102173. PMID 38104639 DOI: 10.1016/j.arr.2023.102173  0.405
2023 Høilund-Carlsen PF, Revheim ME, Costa T, Alavi A, Kepp KP, Sensi SL, Perry G, Robakis NK, Barrio JR, Vissel B. Passive Alzheimer's immunotherapy: A promising or uncertain option? Ageing Research Reviews. 90: 101996. PMID 37414156 DOI: 10.1016/j.arr.2023.101996  0.346
2023 Kepp KP, Sensi SL, Johnsen KB, Barrio JR, Høilund-Carlsen PF, Neve RL, Alavi A, Herrup K, Perry G, Robakis NK, Vissel B, Espay AJ. The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes. Journal of Alzheimer's Disease : Jad. PMID 37334596 DOI: 10.3233/JAD-230099  0.376
2020 Yoon Y, Voloudakis G, Doran N, Zhang E, Dimovasili C, Chen L, Shao Z, Darmanis S, Tang C, Tang J, Wang VX, Hof PR, Robakis NK, Georgakopoulos A. PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival. Molecular Psychiatry. PMID 32541930 DOI: 10.1038/S41380-020-0812-7  0.362
2020 Robakis NK. What Do Recent Clinical Trials Teach Us About the Etiology of AD. Advances in Experimental Medicine and Biology. 1195: 167. PMID 32468473 DOI: 10.1007/978-3-030-32633-3_23  0.4
2020 Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang R, Hou X, Zhang Y, Robakis NK, Li YM, Dordick JS, Ubarretxena-Belandia I, Wang C. Substrate interaction inhibits γ-secretase production of amyloid-β peptides. Chemical Communications (Cambridge, England). PMID 32016207 DOI: 10.1039/C9Cc09170J  0.365
2019 Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang M, Robakis NK, Li Y, Wang C. SUBSTRATE BINDING INHIBITS γ-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN Alzheimers & Dementia. 15: 1595. DOI: 10.1016/J.Jalz.2019.09.052  0.367
2018 Warren NA, Voloudakis G, Yoon Y, Robakis NK, Georgakopoulos A. The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis. Cellular and Molecular Life Sciences : Cmls. PMID 29428965 DOI: 10.1007/S00018-018-2762-7  0.735
2017 Huang Q, Voloudakis G, Ren Y, Yoon Y, Zhang E, Kajiwara Y, Shao Z, Xuan Z, Lebedev D, Georgakopoulos A, Robakis NK. Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28855274 DOI: 10.1096/Fj.201700447Rr  0.491
2017 Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P. Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci. Human Molecular Genetics. PMID 28335009 DOI: 10.1093/Hmg/Ddx103  0.319
2016 Nikolakopoulou AM, Georgakopoulos A, Robakis NK. Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations. Neurobiology of Aging. 42: 41-9. PMID 27143420 DOI: 10.1016/J.Neurobiolaging.2016.02.028  0.339
2016 Robakis N. Mechanisms of neuronal death in familial Alzheimer disease and therapeutic implications Neurobiology of Aging. 39: S14. DOI: 10.1016/J.Neurobiolaging.2016.01.069  0.304
2015 Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 11965-70. PMID 26372964 DOI: 10.1073/Pnas.1510011112  0.362
2015 Bruban J, Voloudakis G, Huang Q, Kajiwara Y, Al Rahim M, Yoon Y, Shioi J, Gama Sosa MA, Shao Z, Georgakopoulos A, Robakis NK. Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25985800 DOI: 10.1096/Fj.15-270645  0.321
2015 Robakis NK. Molecular neuropathology of Alzheimer dementia and therapeutic approaches. Advances in Experimental Medicine and Biology. 822: 1. PMID 25416969 DOI: 10.1007/978-3-319-08927-0_1  0.364
2014 Robakis NK, Georgakopoulos A. Allelic interference: a mechanism for trans-dominant transmission of loss of function in the neurodegeneration of familial Alzheimer's disease. Neuro-Degenerative Diseases. 13: 126-30. PMID 24081144 DOI: 10.1159/000354241  0.442
2014 Robakis NK. Cell signaling abnormalities may drive neurodegeneration in familial Alzheimer disease. Neurochemical Research. 39: 570-5. PMID 23436150 DOI: 10.1007/S11064-013-1003-6  0.43
2013 Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. The Journal of Biological Chemistry. 288: 32050-63. PMID 24052255 DOI: 10.1074/Jbc.M113.504365  0.426
2013 Xuan Z, Barthet G, Shioi J, Xu J, Georgakopoulos A, Bruban J, Robakis NK. Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B. The Journal of Biological Chemistry. 288: 30495-501. PMID 24025330 DOI: 10.1074/Jbc.M113.499004  0.57
2013 Barthet G, Dunys J, Shao Z, Xuan Z, Ren Y, Xu J, Arbez N, Mauger G, Bruban J, Georgakopoulos A, Shioi J, Robakis NK. Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiology of Aging. 34: 499-510. PMID 22475621 DOI: 10.1016/J.Neurobiolaging.2012.02.024  0.578
2012 Barthet G, Georgakopoulos A, Robakis NK. Cellular mechanisms of γ-secretase substrate selection, processing and toxicity. Progress in Neurobiology. 98: 166-75. PMID 22622135 DOI: 10.1016/J.Pneurobio.2012.05.006  0.388
2011 Xu J, Xilouri M, Bruban J, Shioi J, Shao Z, Papazoglou I, Vekrellis K, Robakis NK. Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling. Neurobiology of Aging. 32: 2326.e5-16. PMID 21820214 DOI: 10.1016/J.Neurobiolaging.2011.06.017  0.336
2011 Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G, Robakis NK. Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3594-604. PMID 21746865 DOI: 10.1096/Fj.11-187856  0.404
2011 Robakis NK. Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives. Neurobiology of Aging. 32: 372-9. PMID 20594619 DOI: 10.1016/J.Neurobiolaging.2010.05.022  0.437
2010 Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14946-54. PMID 21068297 DOI: 10.1523/Jneurosci.4305-10.2010  0.395
2010 Robakis NK. Are Abeta and its derivatives causative agents or innocent bystanders in AD? Neuro-Degenerative Diseases. 7: 32-7. PMID 20160455 DOI: 10.1159/000266476  0.448
2009 Xu J, Litterst C, Georgakopoulos A, Zaganas I, Robakis NK. Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 27220-8. PMID 19661068 DOI: 10.1074/Jbc.M109.048728  0.356
2009 Eder-Colli L, Abad-Estarlich N, Pannetier C, Vallet PG, Walzer C, Elder GA, Robakis NK, Bouras C, Savioz A. The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells. Brain Research Bulletin. 80: 296-301. PMID 19555743 DOI: 10.1016/J.Brainresbull.2009.06.007  0.343
2009 Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 731-40. PMID 19387109 DOI: 10.3233/Jad-2009-1021  0.492
2009 Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK. p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. The Journal of Biological Chemistry. 284: 1954-61. PMID 19008223 DOI: 10.1074/Jbc.M806250200  0.66
2008 Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 483-90. PMID 18184791 DOI: 10.1523/Jneurosci.4067-07.2008  0.328
2008 Shioi J, Kouchi Z, Chan J, Robakis NK. P4-216: The cadherin-binding factor p120 promotes the γ-secretase processing of cadherins but inhibits APP processing and Aβ production Alzheimer's & Dementia. 4: T734-T735. DOI: 10.1016/J.Jalz.2008.05.2284  0.314
2008 Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. P4-195: Presenilin1 prevents neurodegeneration by stimulating PI3K/Akt neuroprotective signaling: Effects of PS1 familial Alzheimer's disease mutations Alzheimer's & Dementia. 4: T728-T728. DOI: 10.1016/J.Jalz.2008.05.2262  0.327
2007 Fassa A, Parisiadou L, Robakis NK, Efthimiopoulos S. Novel processing of Notch 1 within its intracellular domain by a cysteine protease. Neuro-Degenerative Diseases. 4: 148-55. PMID 17596709 DOI: 10.1159/000101839  0.764
2007 Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK. Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. The Journal of Biological Chemistry. 282: 16155-63. PMID 17428795 DOI: 10.1074/Jbc.M611449200  0.332
2007 Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK. FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta. Journal of Neurochemistry. 101: 674-81. PMID 17254019 DOI: 10.1111/J.1471-4159.2006.04391.X  0.407
2006 Robakis NK. The discovery and mapping to chromosome 21 of the Alzheimer's amyloid gene: history revised. Journal of Alzheimer's Disease : Jad. 10: 453-5. PMID 17183160 DOI: 10.3233/Jad-2006-10417  0.389
2006 Arnaud L, Robakis NK, Figueiredo-Pereira ME. It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease. Neuro-Degenerative Diseases. 3: 313-9. PMID 16954650 DOI: 10.1159/000095638  0.39
2006 Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. The Embo Journal. 25: 1242-52. PMID 16511561 DOI: 10.1038/Sj.Emboj.7601031  0.609
2006 Agiostratidou G, Muros RM, Shioi J, Marambaud P, Robakis NK. The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. Journal of Neurochemistry. 96: 1182-8. PMID 16417575 DOI: 10.1111/J.1471-4159.2005.03616.X  0.417
2006 Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. O3-03-02: PS1/γ-secretase regulate the EphB-induced Src signaling Alzheimer's & Dementia. 2: S56-S57. DOI: 10.1016/J.Jalz.2006.05.206  0.562
2006 Robakis NK, Baki L. P3-409: Presenilin FAD mutants promote neurodegeneration and AD pathology by inhibiting the presenilin function in PI3K/Akt signaling Alzheimer's & Dementia. 2: S496-S496. DOI: 10.1016/J.Jalz.2006.05.1680  0.338
2006 Shioi J, Dolcini V, Baki L, Mehta P, Georgakopoulos T, Robakis NK. P3-220: Test of PI3K/Akt signaling hypothesis for mechanism of AD using unique PS1 FAD mutations that do not affect Aβ42 production Alzheimer's & Dementia. 2: S440-S440. DOI: 10.1016/J.Jalz.2006.05.1489  0.33
2005 Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK. Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. The Journal of Biological Chemistry. 280: 36007-12. PMID 16126725 DOI: 10.1074/Jbc.M507503200  0.628
2004 Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Experimental Neurology. 188: 224-37. PMID 15246822 DOI: 10.1016/J.Expneurol.2004.04.002  0.326
2004 Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. The Embo Journal. 23: 2586-96. PMID 15192701 DOI: 10.1038/Sj.Emboj.7600251  0.354
2004 Umehara Y, Yamada S, Nishimura S, Shioi J, Robakis NK, Sugahara K. Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors. Febs Letters. 557: 233-8. PMID 14741373 DOI: 10.1016/S0014-5793(03)01506-0  0.353
2004 Baki L, Shioi J, Wen P, Shao Z, Gama-Sosa M, Schwarzman A, Neve R, Robakis NK. P4-307 PS1 suppresses apoptosis and prevents Tau hyperphosphorylation via cadherin/PI3K signaling; effects of PS1 FAD mutations Neurobiology of Aging. 25: S562-S563. DOI: 10.1016/S0197-4580(04)81865-7  0.302
2004 Serban G, Marambaud P, Litterst C, Robakis N. P3-330 γ-secretase processing of VE-cadherin regulates CBP-mediated transcription Neurobiology of Aging. 25: S449. DOI: 10.1016/S0197-4580(04)81480-5  0.571
2004 Agiostratidou G, Minana R, Shoi J, Robakis NK. P1-232 The E-cadherin intracellular fragment, released by the γ-secretase-like cleavage, stimulates degradation of the precursors of Abeta peptide Neurobiology of Aging. 25: S162. DOI: 10.1016/S0197-4580(04)80545-1  0.344
2004 Robakis NK. PL-4-1 Alzheimer's disease: emerging pathogenic mechanisms based on inhibition of PS1 function in signal transduction Neurobiology of Aging. 25: S66. DOI: 10.1016/S0197-4580(04)80222-7  0.334
2004 Marambaud P, Wen PH, Dutt A, Shioi J, Serban G, Takashima A, Siman R, Robakis NK. O3-05-02 FAD-linked presenilin-1 mutations affect the N-cadherin/CBP signaling pathway via a loss-of-function mechanism Neurobiology of Aging. 25: S61-S62. DOI: 10.1016/S0197-4580(04)80207-0  0.566
2003 Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. The Journal of Biological Chemistry. 278: 50970-7. PMID 14507922 DOI: 10.1074/Jbc.M307699200  0.411
2003 Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell. 114: 635-45. PMID 13678586 DOI: 10.1016/J.Cell.2003.08.008  0.357
2003 Robakis NK. An Alzheimer's disease hypothesis based on transcriptional dysregulation. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 10: 80-5. PMID 12964415 DOI: 10.3109/13506120309041729  0.379
2002 Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiology of Disease. 10: 8-19. PMID 12079399 DOI: 10.1006/Nbdi.2002.0490  0.326
2002 Bussière T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, Giannakopoulos P, Robakis NK, Morrison JH, Perl DP, Hof PR. Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience. 112: 75-91. PMID 12044473 DOI: 10.1016/S0306-4522(02)00056-8  0.335
2002 Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. The Embo Journal. 21: 1948-56. PMID 11953314 DOI: 10.1093/Emboj/21.8.1948  0.748
2002 Wen PH, Friedrich VL, Shioi J, Robakis NK, Elder GA. Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice. Neuroscience Letters. 318: 53-6. PMID 11796184 DOI: 10.1016/S0304-3940(01)02485-5  0.313
2001 Tsuchida K, Shioi J, Yamada S, Boghosian G, Wu A, Cai H, Sugahara K, Robakis NK. Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region. The Journal of Biological Chemistry. 276: 37155-60. PMID 11479316 DOI: 10.1074/Jbc.M105818200  0.36
2001 Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 2381-6. PMID 11226248 DOI: 10.1073/Pnas.041603398  0.678
2000 Georgakopoulos A, Marambaud P, Friedrich VL, Shioi J, Efthimiopoulos S, Robakis NK. Presenilin-1: a component of synaptic and endothelial adherens junctions. Annals of the New York Academy of Sciences. 920: 209-14. PMID 11193152 DOI: 10.1111/J.1749-6632.2000.Tb06924.X  0.613
2000 Blitzer RD, Wong T, Giovannini MG, Pangalos MN, Robakis NK, Landau EM. Amyloid beta peptides activate the phosphoinositide signaling pathway in oocytes expressing rat brain RNA. Brain Research. Molecular Brain Research. 76: 115-20. PMID 10719221 DOI: 10.1016/S0169-328X(99)00340-X  0.412
2000 Robakis N, Marambaud P, Baki L, Georgakopoulos A, Shioi J, Serhan G, Cui W, Efthimiopoulos S. Presenilin-1 is a component of synaptic and endothelial adherens junctions: Implications for FAD Neurobiology of Aging. 21: 70. DOI: 10.1016/S0197-4580(00)82533-6  0.617
2000 Baki L, Marambaud P, Efthimiopoulos S, Wen P, Georgakopoulos T, Robakis NK. PS1 is a regulatory component of the cadherin/catenin adherens junction system Neurobiology of Aging. 21: 68. DOI: 10.1016/S0197-4580(00)82527-0  0.627
2000 Georgakopoulos T, Shioi J, Gordon R, Holstein GR, Martinelli G, Efthimiopoulos S, Friedrich VL, Robakis NK. Localization of presenilin at synaptic sites Neurobiology of Aging. 21: 182. DOI: 10.1016/S0197-4580(00)82160-0  0.609
2000 Marambaud P, Baki L, Georgakopoulos A, Shioi J, Efthimiopoulos S, Ozawa M, Robakis NK. Molecular organization of presenilin 1 in the E-cadherin/catenins cell adhesion system Neurobiology of Aging. 21: 181. DOI: 10.1016/S0197-4580(00)82151-X  0.629
1999 Omar RA, Chyan YJ, Andorn AC, Poeggeler B, Robakis NK, Pappolla MA. Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 1: 139-145. PMID 12213999 DOI: 10.3233/Jad-1999-1301  0.56
1999 Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schütte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL, Robakis NK. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Molecular Cell. 4: 893-902. PMID 10635315 DOI: 10.1016/S1097-2765(00)80219-1  0.67
1999 Giannakopoulos P, Kövari E, Buée L, Shioi J, Hof PR, Robakis NK, Bouras C. Presenilin-1 expression in Pick's disease. Acta Neuropathologica. 98: 488-92. PMID 10541872 DOI: 10.1007/S004010051114  0.348
1999 Robakis NK, Efthimiopoulos S. Familial Alzheimer disease: changes in Abeta production may indicate a disturbance in protein transport or function caused by pleiotropic effects of FAD mutations. Neurobiology of Aging. 20: 81-3; discussion 87. PMID 10466898 DOI: 10.1016/S0197-4580(99)00011-1  0.643
1999 Figueiredo-Pereira ME, Efthimiopoulos S, Tezapsidis N, Buku A, Ghiso J, Mehta P, Robakis NK. Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively. Journal of Neurochemistry. 72: 1417-22. PMID 10098844 DOI: 10.1046/J.1471-4159.1999.721417.X  0.709
1999 Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. The Journal of Biological Chemistry. 274: 3165-72. PMID 9915856 DOI: 10.1074/jbc.274.5.3165  0.676
1998 Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook VY, Wisniewski T, Buee L, Robakis NK. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. Journal of Neurochemistry. 71: 2365-72. PMID 9832134 DOI: 10.1046/J.1471-4159.1998.71062365.X  0.671
1998 Bursztajn S, DeSouza R, McPhie DL, Berman SA, Shioi J, Robakis NK, Neve RL. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9790-9. PMID 9822738 DOI: 10.1523/Jneurosci.18-23-09790.1998  0.36
1998 Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. The Journal of Biological Chemistry. 273: 7185-8. PMID 9516407 DOI: 10.1074/Jbc.273.13.7185  0.627
1998 Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook VY, Robakis NK. Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 37: 1274-82. PMID 9477953 DOI: 10.1021/Bi9714159  0.671
1998 Neve RL, Robakis NK. Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends in Neurosciences. 21: 15-9. PMID 9464679 DOI: 10.1016/S0166-2236(97)01168-5  0.391
1997 Wu A, Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4987-93. PMID 9185536 DOI: 10.1523/Jneurosci.17-13-04987.1997  0.667
1997 Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1683-90. PMID 9030627 DOI: 10.1523/Jneurosci.17-05-01683.1997  0.753
1997 Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DLM, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide The Journal of Neuroscience. 17: 1683-1690. DOI: 10.1523/JNEUROSCI.17-05-01683.1997  0.587
1996 Pangalos MN, Shioi J, Efthimiopoulos S, Wu A, Robakis NK. Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 445-51. PMID 9117561 DOI: 10.1006/Neur.1996.0061  0.712
1996 Elder GA, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, Johnston JM, Efthimiopoulos S, Friedrich VL, Robakis NK. Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. Journal of Neuroscience Research. 45: 308-20. PMID 8841992 DOI: 10.1002/(Sici)1097-4547(19960801)45:3<308::Aid-Jnr13>3.0.Co;2-#  0.64
1996 Efthimiopoulos S, Punj S, Manolopoulos V, Pangalos M, Wang GP, Refolo LM, Robakis NK. Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein. Journal of Neurochemistry. 67: 872-5. PMID 8764618 DOI: 10.1046/J.1471-4159.1996.67020872.X  0.697
1996 Efthimiopoulos S, Vassilacopoulou D, Ripellino JA, Tezapsidis N, Robakis NK. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 8046-50. PMID 8755600 DOI: 10.1073/Pnas.93.15.8046  0.71
1996 Shioi J, Pangalos MN, Wu A, Robakis NK. Structure and function of appican, the proteoglycan form of the alzheimer amyloid precursor Trends in Glycoscience and Glycotechnology. 8: 253-263. DOI: 10.4052/Tigg.8.253  0.4
1996 Pappolla M, Sos M, Reiter R, Sambamurti K, Omar R, Robakis N, Efthimiopoulos S. 589 Melatonin prevents oxidative damage and heat-shock protein induction in cultured cells exposed to the Alzheimer's amyloid beta protein (Aβ) Neurobiology of Aging. 17: S146-S147. DOI: 10.1016/S0197-4580(96)80591-4  0.76
1996 Vassilacopoulou D, Efthimiopoulos S, Koliopoulou P, Robakis N. 396 Soluble full length app in synaptosomes and biological fluids Neurobiology of Aging. 17: S99. DOI: 10.1016/S0197-4580(96)80398-8  0.624
1996 Robakis N, Elder G, Tezapsidis N, Carter J, Shioi J, Bourse C, Eflhimiopoulos S. 148 Identification and brain expression of the S182/presenilin I. Relationship to APP processing Neurobiology of Aging. 17: S38. DOI: 10.1016/S0197-4580(96)80150-3  0.307
1996 Shioi J, Tezapsidis N, Carter J, Elder G, Li D, Efthimiopoulos S, Friedrich V, Robakis N. 64 Identification of neuron specific expression of the S182/presenilin I protein Neurobiology of Aging. 17: S16. DOI: 10.1016/S0197-4580(96)80066-2  0.646
1995 Shioi J, Pangalos MN, Ripellino JA, Vassilacopoulou D, Mytilineou C, Margolis RU, Robakis NK. The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures. The Journal of Biological Chemistry. 270: 11839-44. PMID 7744833 DOI: 10.1074/Jbc.270.20.11839  0.391
1995 Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene. The Journal of Biological Chemistry. 270: 10388-91. PMID 7737970 DOI: 10.1074/Jbc.270.18.10388  0.708
1995 Vassilacopoulou D, Ripellino JA, Tezapsidis N, Hook VY, Robakis NK. Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism. Journal of Neurochemistry. 64: 2140-6. PMID 7722498 DOI: 10.1046/J.1471-4159.1995.64052140.X  0.431
1995 Pappolla MA, Sambamurti K, Efthimiopoulos S, Refolo L, Omar RA, Robakis NK. Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins. Neuroscience Letters. 192: 105-8. PMID 7675314 DOI: 10.1016/0304-3940(95)11627-9  0.738
1995 Pangalos MN, Shioi J, Robakis NK. Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2. Journal of Neurochemistry. 65: 762-9. PMID 7616233 DOI: 10.1046/J.1471-4159.1995.65020762.X  0.451
1995 Refolo LM, Sambamurti K, Efthimiopoulos S, Pappolla MA, Robakis NK. Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. Journal of Neuroscience Research. 40: 694-706. PMID 7602619 DOI: 10.1002/Jnr.490400515  0.742
1994 Efthimiopoulos S, Felsenstein KM, Sambamurti K, Robakis NK, Refolo LM. Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. Journal of Neuroscience Research. 38: 81-90. PMID 8057394 DOI: 10.1002/Jnr.490380111  0.673
1994 Robakis NK, Pappolla MA. Oxygen-free radicals and amyloidosis in Alzheimer's disease: is there a connection? Neurobiology of Aging. 15: 457-9; discussion 47. PMID 7969722 DOI: 10.1016/0197-4580(94)90077-9  0.566
1994 Robakis NK, Pangalos MN. Involvement of amyloid as a central step in the development of Alzheimer's disease. Neurobiology of Aging. 15: S127-9. PMID 7700436 DOI: 10.1016/0197-4580(94)90189-9  0.372
1994 Ripellino JA, Vassilacopoulou D, Robakis NK. Solubilization of full-length amyloid precursor proteins from PC12 cell membranes. Journal of Neuroscience Research. 39: 211-8. PMID 7530778 DOI: 10.1002/jnr.490390211  0.326
1993 Shioi J, Refolo LM, Efthimiopoulos S, Robakis NK. Chondroitin sulfate proteoglycan form of cellular and cell-surface Alzheimer amyloid precursor. Neuroscience Letters. 154: 121-4. PMID 8361624 DOI: 10.1016/0304-3940(93)90186-O  0.712
1993 Robakis NK, Vassilacopoulou D, Efthimiopoulos S, Sambamurti K, Refolo LM, Shioi J. Cellular processing and proteoglycan nature of amyloid precursor proteins. Annals of the New York Academy of Sciences. 695: 132-8. PMID 8239271 DOI: 10.1111/J.1749-6632.1993.Tb23041.X  0.721
1992 Shioi J, Anderson JP, Ripellino JA, Robakis NK. Chondroitin sulfate proteoglycan form of the Alzheimer's beta-amyloid precursor. The Journal of Biological Chemistry. 267: 13819-22. PMID 1629183  0.336
1992 Sambamurti K, Shioi J, Anderson JP, Pappolla MA, Robakis NK. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. Journal of Neuroscience Research. 33: 319-29. PMID 1453494 DOI: 10.1002/jnr.490330216  0.61
1992 Pappolla MA, Omar RA, Sambamurti K, Anderson JP, Robakis NK. The genesis of the senile plaque. Further evidence in support of its neuronal origin. The American Journal of Pathology. 141: 1151-9. PMID 1443049  0.589
1992 Anderson JP, Chen Y, Kim KS, Robakis NK. An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence. Journal of Neurochemistry. 59: 2328-31. PMID 1431910  0.37
1992 Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C. A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathologica. 83: 170-8. PMID 1373017 DOI: 10.1007/Bf00308476  0.348
1992 Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. The American Journal of Pathology. 140: 621-8. PMID 1372157  0.592
1992 Sambamurti K, Refolo LM, Shioi J, Pappolla MA, Robakis NK. The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Annals of the New York Academy of Sciences. 674: 118-28. PMID 1283818 DOI: 10.1111/j.1749-6632.1992.tb27481.x  0.575
1991 Anderson JP, Esch FS, Keim PS, Sambamurti K, Lieberburg I, Robakis NK. Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neuroscience Letters. 128: 126-8. PMID 1922940 DOI: 10.1016/0304-3940(91)90775-O  0.314
1991 Robakis NK, Anderson JP, Refolo LM, Wallace W. Expression of the Alzheimer amyloid precursor in brain tissue and effects of NGF and EGF on its metabolism. Clinical Neuropharmacology. 14: S15-23. PMID 1913706 DOI: 10.1097/00002826-199114001-00004  0.409
1991 Probst A, Langui D, Ipsen S, Robakis N, Ulrich J. Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques. Acta Neuropathologica. 83: 21-9. PMID 1724335 DOI: 10.1007/Bf00294426  0.35
1991 Refolo LM, Wittenberg IS, Friedrich VL, Robakis NK. The Alzheimer amyloid precursor is associated with the detergent-insoluble cytoskeleton. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3888-97. PMID 1683901 DOI: 10.1523/Jneurosci.11-12-03888.1991  0.463
1990 Berkenbosch F, Refolo LM, Friedrich VL, Casper D, Blum M, Robakis NK. The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia. Journal of Neuroscience Research. 25: 431-40. PMID 2109094 DOI: 10.1002/Jnr.490250321  0.399
1990 Brown HR, Goller NL, Rudelli RD, Merz GS, Wolfe GC, Wisniewski HM, Robakis NK. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. Acta Neuropathologica. 80: 1-6. PMID 1972856 DOI: 10.1007/Bf00294214  0.502
1989 Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Robakis NK, Wisniewski KE, Silverman WP, Reisberg B, Wisniewski HM. Beta-amyloid protein probe hybridized to chromosome 9 in 3 Alzheimer disease individuals. Progress in Clinical and Biological Research. 317: 269-75. PMID 2690102 DOI: 10.1097/00002093-198802030-00134  0.499
1989 Anderson JP, Refolo LM, Wallace W, Mehta P, Krishnamurthi M, Gotlib J, Bierer L, Haroutunian V, Perl D, Robakis NK. Differential brain expression of the Alzheimer's amyloid precursor protein. The Embo Journal. 8: 3627-32. PMID 2583112 DOI: 10.1002/J.1460-2075.1989.Tb08536.X  0.316
1989 La Fauci G, Lahiri DK, Salton SR, Robakis NK. Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene. Biochemical and Biophysical Research Communications. 159: 297-304. PMID 2538123 DOI: 10.1016/0006-291X(89)92437-6  0.34
1989 Refolo LM, Salton SR, Anderson JP, Mehta P, Robakis NK. Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures. Biochemical and Biophysical Research Communications. 164: 664-70. PMID 2510719 DOI: 10.1016/0006-291X(89)91511-8  0.385
1989 Wallace W, Krishnamurthi M, Gotlib J, Refolo L, Haroutunian V, Robakis NK. Characterization of newly synthesized beta-amyloid precursor protein in rat and human Biological Psychiatry. 25: A118. DOI: 10.1016/0006-3223(89)91724-1  0.357
1989 Anderson JP, Refolo LM, Haroutunian V, Bierer L, Perl D, Robakis NK, Davis KL. Processing and regional specificity of variant forms of the Alzheimer amyloid precursor protein Biological Psychiatry. 25. DOI: 10.1016/0006-3223(89)91721-6  0.399
1989 Robakis N, Refolo L, Salton S, Anderson J. Effects of nerve growth factor on the expression and post-translational processing of the beta-amyloid precursor proteins in PC12 cells Biological Psychiatry. 25: A116. DOI: 10.1016/0006-3223(89)91720-4  0.364
1988 Jenkins EC, Devine-Gage EA, Robakis NK, Yao XL, Brown WT, Houck GE, Wolfe G, Ramakrishna N, Silverman WP, Wisniewski HM. Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein. Biochemical and Biophysical Research Communications. 151: 1-8. PMID 3279948 DOI: 10.1016/0006-291X(88)90551-7  0.534
1988 Wu Y, Dobkin C, Devine-Gage E, Ramakrishna N, Brown WT, Wisniewski HM, Robakis NK. A high frequency NcoI RFLP detected in the Alzheimer amyloid peptide gene. Nucleic Acids Research. 16: 1647. PMID 2894637 DOI: 10.1093/nar/16.4.1647  0.425
1988 WALLACE W, ANDERSON J, HAROTUNIAN V, ROBAKIS NK. CHARACTERIZATION OF PROTEIN SYNTHESIS DURING ALZHEIMER??S DISEASE Alzheimer Disease & Associated Disorders. 2: 282. DOI: 10.1097/00002093-198802030-00131  0.345
1988 Lafauci G, Lahiri D, Refolo L, Wallace W, Anderson J, Mehta P, Robakis NK. STRUCTURAL AND EXPRESSION STUDIES OF THE ALZHEIMER AMYLOID PRECURSOR Alzheimer Disease & Associated Disorders. 2: 279. DOI: 10.1097/00002093-198802030-00128  0.369
1988 Devine-Gage EA, Jenkins EC, Brown WT, Robakis NK, Wisniewski HM. The genetics of Familial Alzheimer's Disease Age. 11: 98-102. DOI: 10.1007/Bf02431747  0.504
1987 Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 84: 4190-4. PMID 3035574 DOI: 10.1073/Pnas.84.12.4190  0.515
1987 Reeves RH, Robakis NK, Oster-Granite ML, Wisniewski HM, Coyle JT, Gearhart JD. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Research. 388: 215-21. PMID 2960420 DOI: 10.1016/0169-328X(87)90028-3  0.495
1987 David F, Robakis NK, Lucotte G. A new TaqI polymorphism detected by the cDNA encoding amyloid beta protein of Alzheimer's disease. Nucleic Acids Research. 15: 9103. PMID 2891111 DOI: 10.1093/Nar/15.21.9103  0.395
1987 Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Wisniewski HM, Robakis NK. In-situ hybridisation of the beta-amyloid protein probe to chromosome 9 in patients with familial Alzheimer's disease. Lancet. 2: 1155-6. PMID 2890057 DOI: 10.1016/S0140-6736(87)91591-1  0.469
1987 Wu Y, Brown WT, Robakis NK, Dobkin C, Devine-Gage E, Merz P, Wisniewski HM. A PvuII RFLP detected in the human prion protein (PrP) gene. Nucleic Acids Research. 15: 3191. PMID 2882483 DOI: 10.1093/Nar/15.7.3191  0.446
1987 Robakis NK, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yao XL, Ramakrishna N, Wolfe G, Silverman WP, Brown WT. Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet. 1: 384-5. PMID 2880184 DOI: 10.1016/S0140-6736(87)91754-5  0.454
1986 Robakis NK, Sawh PR, Wolfe GC, Rubenstein R, Carp RI, Innis MA. Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues. Proceedings of the National Academy of Sciences of the United States of America. 83: 6377-81. PMID 3529083 DOI: 10.1073/Pnas.83.17.6377  0.311
1986 Kascsak RJ, Rubenstein R, Merz PA, Carp RI, Robakis NK, Wisniewski HM, Diringer H. Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. Journal of Virology. 59: 676-83. PMID 2426470  0.364
1986 Rubenstein R, Kascsak RJ, Merz PA, Papini MC, Carp RI, Robakis NK, Wisniewski HM. Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations. The Journal of General Virology. 67: 671-81. PMID 2420924 DOI: 10.1099/0022-1317-67-4-671  0.476
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