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Jeffrey M. Friedman - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Area:
molecular mechanisms that regulate food intake and body weight
Website:
http://www.rockefeller.edu/research/faculty/abstract.php?id=41

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Azevedo EP, Ivan VJ, Friedman JM, Stern SA. Higher-Order Inputs Involved in Appetite Control. Biological Psychiatry. PMID 34593204 DOI: 10.1016/j.biopsych.2021.07.015  0.774
2021 Parolari L, Schneeberger M, Heintz N, Friedman JM. Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice. Molecular Psychiatry. PMID 34099874 DOI: 10.1038/s41380-021-01162-6  0.809
2021 Ito K, Schneeberger M, Gerber A, Jishage M, Marchildon F, Maganti AV, Cohen P, Friedman JM, Roeder RG. Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues. Genes & Development. PMID 33888560 DOI: 10.1101/gad.346791.120  0.58
2021 Stern SA, Azevedo EP, Pomeranz LE, Doerig KR, Ivan VJ, Friedman JM. Top-down control of conditioned overconsumption is mediated by insular cortex Nos1 neurons. Cell Metabolism. PMID 33761312 DOI: 10.1016/j.cmet.2021.03.001  0.785
2021 Caglar C, Friedman J. Restriction of food intake by PPP1R17-expressing neurons in the DMH. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33753517 DOI: 10.1073/pnas.2100194118  0.35
2020 Azevedo EP, Tan B, Pomeranz LE, Ivan V, Fetcho R, Schneeberger M, Doerig KR, Liston C, Friedman JM, Stern SA. A limbic circuit selectively links active escape to food suppression. Elife. 9. PMID 32894221 DOI: 10.7554/Elife.58894  0.805
2020 Tao P, Kuang Y, Li Y, Li W, Gao Z, Liu L, Qiang M, Zha Z, Fan K, Ma P, Friedman JM, Yang G, Lerner RA. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 7: 2000818. PMID 32832353 DOI: 10.1002/Advs.202000818  0.302
2020 Wang P, Loh KH, Wu M, Morgan DA, Schneeberger M, Yu X, Chi J, Kosse C, Kim D, Rahmouni K, Cohen P, Friedman J. A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue. Nature. PMID 32699414 DOI: 10.1038/S41586-020-2527-Y  0.611
2020 Hedbacker K, Lu YH, Dallner O, Li Z, Fayzikhodjaeva G, Birsoy K, Han C, Yang C, Friedman JM. Limitation of adipose tissue by the number of embryonic progenitor cells. Elife. 9. PMID 32452759 DOI: 10.7554/Elife.53074  0.664
2020 Azevedo EP, Tan B, Pomeranz LE, Ivan V, Fetcho R, Schneeberger M, Doerig KR, Liston C, Friedman JM, Stern SA. Author response: A limbic circuit selectively links active escape to food suppression Elife. DOI: 10.7554/Elife.58894.Sa2  0.767
2020 Hedbacker K, Lu Y, Dallner O, Li Z, Fayzikhodjaeva G, Birsoy K, Han C, Yang C, Friedman JM. Author response: Limitation of adipose tissue by the number of embryonic progenitor cells Elife. DOI: 10.7554/Elife.53074.Sa2  0.631
2020 Stern S, Pomeranz L, Azevedo E, Doerig K, Friedman J. A Molecularly Defined Insular to Central Amygdala Circuit Controls Conditioned Overconsumption Biological Psychiatry. 87: S136. DOI: 10.1016/J.Biopsych.2020.02.363  0.752
2019 Schneeberger M, Parolari L, Das Banerjee T, Bhave V, Wang P, Patel B, Topilko T, Wu Z, Choi CHJ, Yu X, Pellegrino K, Engel EA, Cohen P, Renier N, Friedman JM, et al. Regulation of Energy Expenditure by Brainstem GABA Neurons. Cell. PMID 31257028 DOI: 10.1016/J.Cell.2019.05.048  0.79
2019 Azevedo EP, Pomeranz L, Cheng J, Schneeberger M, Vaughan R, Stern SA, Tan B, Doerig K, Greengard P, Friedman JM. A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake. Neuron. PMID 30930044 DOI: 10.1016/J.Neuron.2019.03.011  0.8
2019 Dallner OS, Marinis JM, Lu YH, Birsoy K, Werner E, Fayzikhodjaeva G, Dill BD, Molina H, Moscati A, Kutalik Z, Marques-Vidal P, Kilpeläinen TO, Grarup N, Linneberg A, Zhang Y, ... ... Friedman JM, et al. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity. Nature Medicine. PMID 30842678 DOI: 10.1038/S41591-019-0370-1  0.666
2018 Zhang H, Chaudhury D, Nectow AR, Friedman AK, Zhang S, Juarez B, Liu H, Pfau ML, Aleyasin H, Jiang C, Crumiller M, Calipari ES, Ku SM, Morel C, Tzavaras N, ... ... Friedman JM, et al. α- and β-Adrenergic Receptor-Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice. Biological Psychiatry. PMID 30336931 DOI: 10.1016/J.Biopsych.2018.08.020  0.748
2018 Tabansky I, Liang Y, Frankfurt M, Daniels MA, Harrigan M, Stern S, Milner TA, Leshan R, Rama R, Moll T, Friedman JM, Stern JNH, Pfaff DW. Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal. Proceedings of the National Academy of Sciences of the United States of America. PMID 29967172 DOI: 10.1073/Pnas.1806123115  0.554
2018 Zhang Y, Dallner OS, Nakadai T, Fayzikhodjaeva G, Lu YH, Lazar MA, Roeder RG, Friedman JM. A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891714 DOI: 10.1073/Pnas.1806366115  0.553
2018 Stern SA, Doerig KR, Azevedo EP, Stoffel E, Friedman JM. Control of non-homeostatic feeding in sated mice using associative learning of contextual food cues. Molecular Psychiatry. PMID 29875477 DOI: 10.1038/S41380-018-0072-Y  0.774
2018 Schneeberger M, Tan K, Nectow AR, Parolari L, Caglar C, Azevedo E, Li Z, Domingos A, Friedman JM. Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons. Molecular Metabolism. PMID 29843980 DOI: 10.1016/J.Molmet.2018.05.001  0.781
2017 Nectow AR, Schneeberger M, Zhang H, Field BC, Renier N, Azevedo E, Patel B, Liang Y, Mitra S, Tessier-Lavigne M, Han MH, Friedman JM. Identification of a Brainstem Circuit Controlling Feeding. Cell. 170: 429-442.e11. PMID 28753423 DOI: 10.1016/J.Cell.2017.06.045  0.811
2017 Nectow AR, Moya MV, Ekstrand MI, Mousa A, McGuire KL, Sferrazza CE, Field BC, Rabinowitz GS, Sawicka K, Liang Y, Friedman JM, Heintz N, Schmidt EF. Rapid Molecular Profiling of Defined Cell Types Using Viral TRAP. Cell Reports. 19: 655-667. PMID 28423326 DOI: 10.1016/J.Celrep.2017.03.048  0.76
2017 Pomeranz LE, Ekstrand MI, Latcha KN, Smith GA, Enquist LW, Friedman JM. Gene expression profiling with Cre-conditional pseudorabies virus reveals a subset of midbrain neurons that participate in reward circuitry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28283558 DOI: 10.1523/Jneurosci.3193-16.2017  0.389
2016 Friedman J. The long road to leptin. Journal of Clinical Investigation. 126: 4727-4734. PMID 27906690 DOI: 10.1172/Jci91578  0.394
2016 Li Z, Kelly L, Heiman M, Greengard P, Friedman JM. Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake. Cell Metabolism. 23: 945. PMID 27166950 DOI: 10.1016/j.cmet.2016.04.014  0.396
2016 Stanley SA, Kelly L, Latcha KN, Schmidt SF, Yu X, Nectow AR, Sauer J, Dyke JP, Dordick JS, Friedman JM. Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism. Nature. PMID 27007848 DOI: 10.1038/Nature17183  0.78
2015 Li Z, Kelly L, Heiman M, Greengard P, Friedman JM. Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake. Cell Metabolism. 22: 1059-67. PMID 26655697 DOI: 10.1016/J.Cmet.2015.10.012  0.591
2015 Friedman J. Leptin and the Regulation of Food Intake and Body Weight. Journal of Nutritional Science and Vitaminology. 61: S202. PMID 26598860 DOI: 10.3177/Jnsv.61.S202  0.322
2015 Zeng W, Pirzgalska RM, Pereira MM, Kubasova N, Barateiro A, Seixas E, Lu YH, Kozlova A, Voss H, Martins GG, Friedman JM, Domingos AI. Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis. Cell. 163: 84-94. PMID 26406372 DOI: 10.1016/J.Cell.2015.08.055  0.723
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405]. Molecular Metabolism. 4: 592. PMID 26266092 DOI: 10.1016/J.Molmet.2015.05.004  0.637
2015 Nectow AR, Ekstrand MI, Friedman JM. Molecular characterization of neuronal cell types based on patterns of projection with Retro-TRAP. Nature Protocols. 10: 1319-27. PMID 26247298 DOI: 10.1038/Nprot.2015.087  0.76
2015 Zeng W, Lu YH, Lee J, Friedman JM. Reanalysis of parabiosis of obesity mutants in the age of leptin. Proceedings of the National Academy of Sciences of the United States of America. PMID 26150485 DOI: 10.1073/Pnas.1510378112  0.391
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression. Molecular Metabolism. 4: 392-405. PMID 25973387 DOI: 10.1016/J.Molmet.2015.02.002  0.679
2015 Stanley SA, Sauer J, Kane RS, Dordick JS, Friedman JM. Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles. Nature Medicine. 21: 92-8. PMID 25501906 DOI: 10.1038/Nm.3730  0.329
2015 Friedman JM, Mantzoros CS. 20 years of leptin: from the discovery of the leptin gene to leptin in our therapeutic armamentarium. Metabolism: Clinical and Experimental. 64: 1-4. PMID 25497341 DOI: 10.1016/J.Metabol.2014.10.023  0.314
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405] Molecular Metabolism. DOI: 10.1016/j.molmet.2015.05.004  0.607
2014 Tan K, Knight ZA, Friedman JM. Ablation of AgRP neurons impairs adaption to restricted feeding. Molecular Metabolism. 3: 694-704. PMID 25352998 DOI: 10.1016/J.Molmet.2014.07.002  0.675
2014 Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. A critical role for mTORC1 in erythropoiesis and anemia. Elife. 3: e01913. PMID 25201874 DOI: 10.7554/Elife.01913  0.737
2014 Friedman J. 20 years of leptin: leptin at 20: an overview. The Journal of Endocrinology. 223: T1-8. PMID 25121999 DOI: 10.1530/Joe-14-0405  0.391
2014 Ekstrand MI, Nectow AR, Knight ZA, Latcha KN, Pomeranz LE, Friedman JM. Molecular profiling of neurons based on connectivity. Cell. 157: 1230-42. PMID 24855954 DOI: 10.1016/J.Cell.2014.03.059  0.794
2014 Domingos AI, Vaynshteyn J, Sordillo A, Friedman JM. The reward value of sucrose in leptin-deficient obese mice. Molecular Metabolism. 3: 73-80. PMID 24567906 DOI: 10.1016/J.Molmet.2013.10.007  0.747
2014 Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison MS, Ferguson D, Golden SA, Koo JW, Chaudhury D, Christoffel DJ, Pomeranz L, Friedman JM, et al. Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nature Neuroscience. 17: 27-9. PMID 24270188 DOI: 10.1038/Nn.3591  0.303
2014 Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. Author response: A critical role for mTORC1 in erythropoiesis and anemia Elife. DOI: 10.7554/Elife.01913.013  0.727
2013 Domingos AI, Sordillo A, Dietrich MO, Liu ZW, Tellez LA, Vaynshteyn J, Ferreira JG, Ekstrand MI, Horvath TL, de Araujo IE, Friedman JM. Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. Elife. 2: e01462. PMID 24381247 DOI: 10.7554/Elife.01462  0.722
2013 Li Z, Ceccarini G, Eisenstein M, Tan K, Friedman JM. Phenotypic effects of an induced mutation of the ObRa isoform of the leptin receptor. Molecular Metabolism. 2: 364-75. PMID 24327953 DOI: 10.1016/J.Molmet.2013.07.007  0.414
2013 Stanley S, Domingos AI, Kelly L, Garfield A, Damanpour S, Heisler L, Friedman J. Profiling of Glucose-Sensing Neurons Reveals that GHRH Neurons Are Activated by Hypoglycemia. Cell Metabolism. 18: 596-607. PMID 24093682 DOI: 10.1016/J.Cmet.2013.09.002  0.755
2013 Li Z, Schmidt SF, Friedman JM. Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth. Diabetes. 62: 2359-67. PMID 23423572 DOI: 10.2337/Db12-0901  0.397
2013 Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Mazei-Robison MS, Mouzon E, ... ... Friedman JM, et al. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature. 493: 532-6. PMID 23235832 DOI: 10.1038/Nature11713  0.793
2013 Domingos AI, Sordillo A, Dietrich MO, Liu Z, Tellez LA, Vaynshteyn J, Ferreira JG, Ekstrand MI, Horvath TL, Araujo IEd, Friedman JM. Author response: Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar Elife. DOI: 10.7554/Elife.01462.019  0.637
2012 Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A, Ekstrand MI, Friedman JM. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell. 151: 1126-37. PMID 23178128 DOI: 10.1016/J.Cell.2012.10.039  0.776
2011 Domingos AI, Vaynshteyn J, Voss HU, Ren X, Gradinaru V, Zang F, Deisseroth K, de Araujo IE, Friedman J. Leptin regulates the reward value of nutrient. Nature Neuroscience. 14: 1562-8. PMID 22081158 DOI: 10.1038/nn.2977  0.74
2011 Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development (Cambridge, England). 138: 4709-19. PMID 21989915 DOI: 10.1242/Jcs.101436  0.644
2011 Ribeiro AC, Ceccarini G, Dupré C, Friedman JM, Pfaff DW, Mark AL. Contrasting effects of leptin on food anticipatory and total locomotor activity. Plos One. 6: e23364. PMID 21853117 DOI: 10.1371/Journal.Pone.0023364  0.388
2011 Donato J, Cravo RM, Frazão R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua S, Coppari R, Zigman JM, et al. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. The Journal of Clinical Investigation. 121: 355-68. PMID 21183787 DOI: 10.1172/Jci45106  0.443
2010 Knight ZA, Hannan KS, Greenberg ML, Friedman JM. Hyperleptinemia is required for the development of leptin resistance. Plos One. 5: e11376. PMID 20613882 DOI: 10.1371/Journal.Pone.0011376  0.67
2010 Stanley S, Pinto S, Segal J, Pérez CA, Viale A, DeFalco J, Cai X, Heisler LK, Friedman JM. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proceedings of the National Academy of Sciences of the United States of America. 107: 7024-9. PMID 20351287 DOI: 10.1073/Pnas.1002790107  0.408
2010 Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metabolism. 11: 11-22. PMID 20074524 DOI: 10.1016/J.Cmet.2009.11.007  0.672
2010 Gautron L, Lee C, Funahashi H, Friedman J, Lee S, Elmquist J. Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions. The Journal of Comparative Neurology. 518: 6-24. PMID 19882715 DOI: 10.1002/Cne.22221  0.39
2010 Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene (DOI:10.1016/j.cmet.2009.11.007) Cell Metabolism. 11: 239. DOI: 10.1016/J.Cmet.2010.02.010  0.649
2009 Singh A, Wirtz M, Parker N, Hogan M, Strahler J, Michailidis G, Schmidt S, Vidal-Puig A, Diano S, Andrews P, Brand MD, Friedman J. Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proceedings of the National Academy of Sciences of the United States of America. 106: 13100-5. PMID 19622746 DOI: 10.1073/Pnas.0903723106  0.358
2009 Wang W, Huang L, Huang Y, Yin JW, Berk AJ, Friedman JM, Wang G. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Developmental Cell. 16: 764-71. PMID 19460352 DOI: 10.1016/J.Devcel.2009.04.006  0.324
2009 Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM, Elmquist JK. Leptin targets in the mouse brain. The Journal of Comparative Neurology. 514: 518-32. PMID 19350671 DOI: 10.1002/Cne.22025  0.73
2008 Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells in vivo. Cell. 135: 240-9. PMID 18835024 DOI: 10.1016/J.Cell.2008.09.036  0.661
2008 Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P, Fayzikhodjaeva G, Viale A, Socci ND, Friedman JM. Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach. Proceedings of the National Academy of Sciences of the United States of America. 105: 12985-90. PMID 18753616 DOI: 10.1073/Pnas.0805621105  0.79
2008 Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 454: 846-51. PMID 18668043 DOI: 10.1038/Nature07181  0.308
2008 Flavell RR, Kothari P, Bar-Dagan M, Synan M, Vallabhajosula S, Friedman JM, Muir TW, Ceccarini G. Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure. Journal of the American Chemical Society. 130: 9106-12. PMID 18570424 DOI: 10.1021/Ja801666Z  0.312
2008 Zeigerer A, Rodeheffer MS, McGraw TE, Friedman JM. Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism. Experimental Cell Research. 314: 2249-56. PMID 18501893 DOI: 10.1016/J.Yexcr.2008.04.003  0.307
2008 Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metabolism. 7: 339-47. PMID 18396140 DOI: 10.1016/J.Cmet.2008.02.001  0.642
2007 Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM. Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metabolism. 5: 115-28. PMID 17276354 DOI: 10.1016/J.Cmet.2007.01.005  0.406
2007 Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, Friedman JM, Ricquier D, Richard D, Horvath TL, Gao XB, Diano S. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metabolism. 5: 21-33. PMID 17189204 DOI: 10.1016/J.Cmet.2006.12.002  0.369
2006 Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, ... ... Friedman JM, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 51: 239-49. PMID 16846858 DOI: 10.1016/J.Neuron.2006.06.004  0.363
2006 Shmulewitz D, Heath SC, Blundell ML, Han Z, Sharma R, Salit J, Auerbach SB, Signorini S, Breslow JL, Stoffel M, Friedman JM. Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia. Proceedings of the National Academy of Sciences of the United States of America. 103: 3502-9. PMID 16537441 DOI: 10.1073/Pnas.0510156103  0.638
2005 Sternson SM, Shepherd GM, Friedman JM. Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting. Nature Neuroscience. 8: 1356-63. PMID 16172601 DOI: 10.1038/Nn1550  0.712
2005 Chen Z, Torrens JI, Anand A, Spiegelman BM, Friedman JM. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metabolism. 1: 93-106. PMID 16054051 DOI: 10.1016/J.Cmet.2004.12.009  0.507
2005 Li D, Yea S, Li S, Chen Z, Narla G, Banck M, Laborda J, Tan S, Friedman JM, Friedman SL, Walsh MJ. Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. The Journal of Biological Chemistry. 280: 26941-52. PMID 15917248 DOI: 10.1074/Jbc.M500463200  0.317
2005 Segal JP, Stallings NR, Lee CE, Zhao L, Socci N, Viale A, Harris TM, Soares MB, Childs G, Elmquist JK, Parker KL, Friedman JM. Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4181-8. PMID 15843621 DOI: 10.1523/Jneurosci.0158-05.2005  0.365
2005 Montez JM, Soukas A, Asilmaz E, Fayzikhodjaeva G, Fantuzzi G, Friedman JM. Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. Proceedings of the National Academy of Sciences of the United States of America. 102: 2537-42. PMID 15699332 DOI: 10.1073/Pnas.0409530102  0.795
2005 Sennello JA, Fayad R, Morris AM, Eckel RH, Asilmaz E, Montez J, Friedman JM, Dinarello CA, Fantuzzi G. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin. Endocrinology. 146: 2157-64. PMID 15677756 DOI: 10.1210/En.2004-1572  0.791
2005 Cohen P, Yang G, Yu X, Soukas AA, Wolfish CS, Friedman JM, Li C. Induction of leptin receptor expression in the liver by leptin and food deprivation. The Journal of Biological Chemistry. 280: 10034-9. PMID 15644325 DOI: 10.1074/Jbc.M413684200  0.761
2005 Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 288: E599-607. PMID 15562249 DOI: 10.1152/Ajpendo.00439.2004  0.5
2005 Brown M, Flier J, Friedman J, Goldstein J, Kahn CR, Lifton R, O'Rahilly S, Spiegelman B. Cell Metabolism: Why, and why now? Cell Metabolism. 1: 3. DOI: 10.1016/J.Cmet.2004.12.007  0.499
2004 Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature. 432: 1027-32. PMID 15616563 DOI: 10.1038/Nature03047  0.339
2004 Cohen P, Friedman JM. Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1). The Journal of Nutrition. 134: 2455S-2463S. PMID 15333742 DOI: 10.1093/Jn/134.9.2455S  0.555
2004 Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proceedings of the National Academy of Sciences of the United States of America. 101: 6409-14. PMID 15096593 DOI: 10.1073/Pnas.0401627101  0.521
2004 Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science (New York, N.Y.). 304: 110-5. PMID 15064421 DOI: 10.1126/Science.1089459  0.471
2004 Roseberry AG, Liu H, Jackson AC, Cai X, Friedman JM. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron. 41: 711-22. PMID 15003171 DOI: 10.1016/S0896-6273(04)00074-1  0.442
2004 Asilmaz E, Cohen P, Miyazaki M, Dobrzyn P, Ueki K, Fayzikhodjaeva G, Soukas AA, Kahn CR, Ntambi JM, Socci ND, Friedman JM. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. The Journal of Clinical Investigation. 113: 414-24. PMID 14755338 DOI: 10.1172/Jci19511  0.76
2003 Cohen P, Ntambi JM, Friedman JM. Stearoyl-CoA desaturase-1 and the metabolic syndrome. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 3: 271-80. PMID 14683458 DOI: 10.2174/1568008033340117  0.579
2003 Liedtke W, Tobin DM, Bargmann CI, Friedman JM. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 100: 14531-6. PMID 14581619 DOI: 10.1073/Pnas.2235619100  0.323
2003 Liedtke W, Friedman JM. Abnormal osmotic regulation in trpv4-/- mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 13698-703. PMID 14581612 DOI: 10.1073/Pnas.1735416100  0.355
2003 Haqq AM, René P, Kishi T, Khong K, Lee CE, Liu H, Friedman JM, Elmquist JK, Cone RD. Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. The Biochemical Journal. 376: 595-605. PMID 14531729 DOI: 10.1042/Bj20031241  0.324
2003 Ishii M, Fei H, Friedman JM. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proceedings of the National Academy of Sciences of the United States of America. 100: 10540-5. PMID 12925742 DOI: 10.1073/Pnas.1334189100  0.416
2003 Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez JM, Friedman JM, Elmquist JK. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7143-54. PMID 12904474 DOI: 10.1523/Jneurosci.23-18-07143.2003  0.785
2003 Miyazaki M, Jacobson MJ, Man WC, Cohen P, Asilmaz E, Friedman JM, Ntambi JM. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. The Journal of Biological Chemistry. 278: 33904-11. PMID 12815040 DOI: 10.1074/Jbc.M304724200  0.547
2003 Chiellini C, Costa M, Novelli SE, Amri EZ, Benzi L, Bertacca A, Cohen P, Del Prato S, Friedman JM, Maffei M. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Journal of Cellular Physiology. 195: 309-21. PMID 12652657 DOI: 10.1002/Jcp.10253  0.572
2003 Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, ... Friedman JM, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 37: 649-61. PMID 12597862 DOI: 10.1016/S0896-6273(03)00063-1  0.379
2002 Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proceedings of the National Academy of Sciences of the United States of America. 99: 11482-6. PMID 12177411 DOI: 10.1073/Pnas.132384699  0.565
2002 Han Z, Heath SC, Shmulewitz D, Li W, Auerbach SB, Blundell ML, Lehner T, Ott J, Stoffel M, Friedman JM, Breslow JL. Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. American Journal of Medical Genetics. 110: 234-42. PMID 12116231 DOI: 10.1002/Ajmg.10445  0.643
2002 Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science (New York, N.Y.). 297: 240-3. PMID 12114623 DOI: 10.1126/Science.1071527  0.78
2002 Chiellini C, Bertacca A, Novelli SE, Görgün CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, ... ... Friedman JM, et al. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. Journal of Cellular Physiology. 190: 251-8. PMID 11807829 DOI: 10.1002/Jcp.10061  0.747
2002 Friedman J. Fat in all the wrong places Nature. 415: 268-269. PMID 11796987 DOI: 10.1038/415268A  0.313
2001 Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, Mombaerts P, Friedman JM. Selective deletion of leptin receptor in neurons leads to obesity. The Journal of Clinical Investigation. 108: 1113-21. PMID 11602618 DOI: 10.1172/Jci13914  0.814
2001 DeFalco J, Tomishima M, Liu H, Zhao C, Cai X, Marth JD, Enquist L, Friedman JM. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science (New York, N.Y.). 291: 2608-13. PMID 11283374 DOI: 10.1126/Science.1056602  0.397
2001 Shmulewitz D, Auerbach SB, Lehner T, Blundell ML, Winick JD, Youngman LD, Skilling V, Heath SC, Ott J, Stoffel M, Breslow JL, Friedman JM. Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Human Heredity. 51: 8-19. PMID 11096265 DOI: 10.1159/000022953  0.659
2000 Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Molecular and Cellular Biology. 20: 5343-9. PMID 10866690 DOI: 10.1128/Mcb.20.14.5343-5349.2000  0.771
2000 Soukas A, Cohen P, Socci ND, Friedman JM. Leptin-specific patterns of gene expression in white adipose tissue. Genes & Development. 14: 963-80. PMID 10783168 DOI: 10.1101/Gad.14.8.963  0.791
2000 Friedman JM. Obesity in the new millennium. Nature. 404: 632-634. PMID 10766249 DOI: 10.1038/35007504  0.342
1999 Li C, Friedman JM. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 96: 9677-82. PMID 10449753 DOI: 10.1073/Pnas.96.17.9677  0.306
1999 Burcelin R, Kamohara S, Li J, Tannenbaum GS, Charron MJ, Friedman JM. Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice. Diabetes. 48: 1264-9. PMID 10342814 DOI: 10.2337/Diabetes.48.6.1264  0.361
1999 Soukas A, Cohen P, Friedman JM. Gene expression profile induced by leptin in white adipose tissue and liver Nature Genetics. 23: 75-75. DOI: 10.1038/14405  0.75
1998 Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 395: 763-70. PMID 9796811 DOI: 10.1038/27376  0.375
1998 Li C, Ioffe E, Fidahusein N, Connolly E, Friedman JM. Absence of soluble leptin receptor in plasma from dbPas/dbPas and other db/db mice. The Journal of Biological Chemistry. 273: 10078-82. PMID 9545355 DOI: 10.1074/Jbc.273.16.10078  0.314
1997 Lee GH, Li C, Montez J, Halaas J, Darvishzadeh J, Friedman JM. Leptin receptor mutations in 129 db (3J)/db(3.J) mice and NIH fa (cp)/fa(cp) rats. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 8: 445-7. PMID 27518443 DOI: 10.1007/S003359900466  0.772
1997 Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature. 389: 374-7. PMID 9311777 DOI: 10.1038/38717  0.341
1997 Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proceedings of the National Academy of Sciences of the United States of America. 94: 7001-5. PMID 9192681 DOI: 10.1073/Pnas.94.13.7001  0.429
1997 Moon BC, Friedman JM. The molecular basis of the obese mutation in ob2J mice. Genomics. 42: 152-156. PMID 9177786 DOI: 10.1006/Geno.1997.4701  0.34
1997 Ravussin E, Pratley RE, Maffei M, Wang H, Friedman JM, Bennett PH, Bogardus C. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nature Medicine. 3: 238-40. PMID 9018247 DOI: 10.1038/Nm0297-238  0.33
1996 Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics. 14: 95-7. PMID 8782827 DOI: 10.1038/Ng0996-95  0.747
1996 Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379: 632-5. PMID 8628397 DOI: 10.1038/379632A0  0.794
1996 Maffei M, Stoffel M, Barone M, Moon B, Dammerman M, Ravussin E, Bogardus C, Ludwig DS, Flier JS, Talley M, Auerbach S, Friedman JM. Absence of mutations in the human OB gene in obese/diabetic subjects Diabetes. 45: 679-682. PMID 8621022 DOI: 10.2337/Diab.45.5.679  0.318
1995 Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science (New York, N.Y.). 269: 543-6. PMID 7624777 DOI: 10.1126/Science.7624777  0.383
1994 Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 372: 425-32. PMID 7984236 DOI: 10.1038/372425A0  0.357
1992 Friedman JM, Leibel RL, Bahary N. Molecular mapping of obesity genes. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 1: 130-44. PMID 1797227 DOI: 10.1007/Bf00351059  0.341
1992 Friedman JM, Leibel RL. Tackling a weighty problem. Cell. 69: 217-20. PMID 1568242 DOI: 10.1016/0092-8674(92)90402-X  0.355
1991 Truett GE, Bahary N, Friedman JM, Leibel RL. Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db). Proceedings of the National Academy of Sciences of the United States of America. 88: 7806-9. PMID 1881916 DOI: 10.1073/Pnas.88.17.7806  0.309
1991 Friedman JM, Leibel RL, Bahary N, Siegel DA, Truett G. Genetic analysis of complex disorders. Molecular mapping of obesity genes in mice and humans. Annals of the New York Academy of Sciences. 630: 100-15. PMID 1683202 DOI: 10.1111/J.1749-6632.1991.Tb19579.X  0.321
1990 Bahary N, Leibel RL, Joseph L, Friedman JM. Molecular mapping of the mouse db mutation. Proceedings of the National Academy of Sciences of the United States of America. 87: 8642-6. PMID 1978328 DOI: 10.1073/Pnas.87.21.8642  0.314
1989 Friedman JM, Schneider BS, Barton DE, Francke U. Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesity. Genomics. 5: 463-9. PMID 2575582 DOI: 10.1016/0888-7543(89)90010-4  0.336
1989 Xanthopoulos KG, Mirkovitch J, Friedman JM, Darnell JE. The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenetics and Cell Genetics. 50: 174-5. PMID 2570675  0.395
1987 Babiss LE, Friedman JM, Darnell JE. Cellular promoters incorporated into the adenovirus genome. Effect of viral DNA replication on endogenous and exogenous gene transcription. Journal of Molecular Biology. 193: 643-50. PMID 3612788 DOI: 10.1016/0022-2836(87)90347-0  0.505
1987 Friedman JM, Babiss LE, Weiss M, Darnell JE. Hepatoma variants (C2) are defective for transcriptional and post-transcriptional actions from both endogenous and viral genomes. The Embo Journal. 6: 1727-31. PMID 2956094 DOI: 10.1002/J.1460-2075.1987.Tb02424.X  0.487
1986 Babiss LE, Bennett A, Friedman JM, Darnell JE. DNase I-hypersensitive sites in the 5'-flanking region of the rat serum albumin gene: correlation between chromatin structure and transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America. 83: 6504-8. PMID 3462709 DOI: 10.1073/Pnas.83.17.6504  0.488
1986 Babiss LE, Friedman JM, Darnell JE. Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters. Molecular and Cellular Biology. 6: 3798-806. PMID 2948109 DOI: 10.1128/Mcb.6.11.3798  0.494
1986 Friedman JM, Babiss LE, Clayton DF, Darnell JE. Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression. Molecular and Cellular Biology. 6: 3791-7. PMID 2948108 DOI: 10.1128/Mcb.6.11.3791  0.512
1984 Friedman JM, Chung EY, Darnell JE. Gene expression during liver regeneration. Journal of Molecular Biology. 179: 37-53. PMID 6502711 DOI: 10.1016/0022-2836(84)90305-X  0.442
1984 Powell DJ, Friedman JM, Oulette AJ, Krauter KS, Darnell JE. Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. Journal of Molecular Biology. 179: 21-35. PMID 6502710 DOI: 10.1016/0022-2836(84)90304-8  0.492
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