| Year |
Citation |
Score |
| 2024 |
Adele R, Hussein R, Tavares E, Ahmed K, Di Scipio M, Charish J, Liang M, Monis S, Tumber A, Chen X, Paton TA, Roslin NM, Eileen C, Ivakine E, Sunny NE, ... ... Rajala RV, et al. Autosomal dominant macular dystrophy linked to a chromosome 17 tandem duplication. Jci Insight. PMID 39436697 DOI: 10.1172/jci.insight.178768 |
0.38 |
|
| 2024 |
Rajala A, Rajala R, Bhat MA, Eminhizer M, Hao J, Du J, Rajala RVS. Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons. Cell Death & Disease. 15: 577. PMID 39117618 DOI: 10.1038/s41419-024-06924-y |
0.524 |
|
| 2024 |
Rajala A, Rajala RVS. Age-Related Changes in the Glycolytic Enzymes of M2-Isoform of Pyruvate Kinase and Fructose-1,6-Bisphosphate Aldolase: Implications to Age-Related Macular Degeneration. Aging and Disease. PMID 38739943 DOI: 10.14336/AD.2024.0077 |
0.431 |
|
| 2024 |
Rajala RVS, Rajala A. From Insight to Eyesight: Unveiling the Secrets of the Insulin-Like Growth Factor Axis in Retinal Health. Aging and Disease. PMID 38300646 DOI: 10.14336/AD.2024.0128 |
0.367 |
|
| 2023 |
Rajala RVS, Rajala A. Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells. Frontiers in Ophthalmology. 3: 1296624. PMID 38983010 DOI: 10.3389/fopht.2023.1296624 |
0.392 |
|
| 2023 |
Rajala A, Rajala R, Gopinadhan Nair GK, Rajala RVS. Atlas of phosphoinositide signatures in the retina identifies heterogeneity between cell types. Pnas Nexus. 2: pgad063. PMID 37007713 DOI: 10.1093/pnasnexus/pgad063 |
0.473 |
|
| 2023 |
Rajala A, Bhat MA, Teel K, Gopinadhan Nair GK, Purcell L, Rajala RVS. The function of lactate dehydrogenase A in retinal neurons: implications to retinal degenerative diseases. Pnas Nexus. 2: pgad038. PMID 36896135 DOI: 10.1093/pnasnexus/pgad038 |
0.509 |
|
| 2022 |
Rajala A, Teel K, Bhat MA, Batushansky A, Griffin TM, Purcell L, Rajala RVS. Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection. Cell Death & Disease. 13: 613. PMID 35840554 DOI: 10.1038/s41419-022-05074-3 |
0.436 |
|
| 2022 |
Fort PE, Losiewicz MK, Elghazi L, Kong D, Cras-Méneur C, Fingar DC, Kimball SR, Rajala RVS, Smith AJ, Ali RR, Abcouwer SF, Gardner TW. mTORC1 Regulates High Levels of Protein Synthesis in Retinal Ganglion Cells of Adult Mice. The Journal of Biological Chemistry. 101944. PMID 35447116 DOI: 10.1016/j.jbc.2022.101944 |
0.471 |
|
| 2022 |
Rajala A, Rajala R, Teel K, Rajala RVS. Ribosomal targeting strategy and nuclear labeling to analyze photoreceptor phosphoinositide signatures. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 159161. PMID 35427794 DOI: 10.1016/j.bbalip.2022.159161 |
0.422 |
|
| 2021 |
Shang P, Stepicheva N, Teel K, McCauley A, Fitting CS, Hose S, Grebe R, Yazdankhah M, Ghosh S, Liu H, Strizhakova A, Weiss J, Bhutto IA, Lutty GA, Jayagopal A, ... ... Rajala RVS, et al. βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells. Communications Biology. 4: 850. PMID 34239035 DOI: 10.1038/s42003-021-02386-6 |
0.348 |
|
| 2021 |
Rajala RVS, McCauley A, Rajala R, Teel K, Rajala A. Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14. Biomolecules. 11. PMID 33921658 DOI: 10.3390/biom11040602 |
0.434 |
|
| 2021 |
Rajala RVS. Signaling roles of phosphoinositides in the retina. Journal of Lipid Research. 100041. PMID 33556433 DOI: 10.1194/jlr.TR120000806 |
0.352 |
|
| 2020 |
Rajala A, He F, Anderson RE, Wensel TG, Rajala RVS. Loss of Class III Phosphoinositide 3-Kinase Vps34 Results in Cone Degeneration. Biology. 9. PMID 33171845 DOI: 10.3390/biology9110384 |
0.59 |
|
| 2020 |
Losiewicz MK, Elghazi L, Fingar DC, Rajala RVS, Lentz SI, Fort PE, Abcouwer SF, Gardner TW. mTORC1 and mTORC2 expression in inner retinal neurons and glial cells. Experimental Eye Research. 108131. PMID 32622801 DOI: 10.1016/j.exer.2020.108131 |
0.502 |
|
| 2020 |
Rajala A, McCauley A, Brush RS, Nguyen K, Rajala RVS. Phosphoinositide Lipids in Ocular Tissues. Biology. 9. PMID 32545642 DOI: 10.3390/biology9060125 |
0.431 |
|
| 2020 |
Rajala RVS. Signaling roles of phosphoinositides in the retina. Journal of Lipid Research. PMID 32540927 DOI: 10.1194/jlr.TR120000806 |
0.374 |
|
| 2020 |
Rajala RVS. Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms. Frontiers in Cell and Developmental Biology. 8: 266. PMID 32426353 DOI: 10.3389/fcell.2020.00266 |
0.327 |
|
| 2020 |
Lee SY, Surbeck JW, Drake M, Saunders A, Jin HD, Shah VA, Rajala RV. Increased Glial Fibrillary Acid Protein and Vimentin in Vitreous Fluid as a Biomarker for Proliferative Vitreoretinopathy. Investigative Ophthalmology & Visual Science. 61: 22. PMID 32413125 DOI: 10.1167/iovs.61.5.22 |
0.455 |
|
| 2020 |
Rajala A, Soni K, Rajala RVS. Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy. Scientific Reports. 10: 7456. PMID 32366925 DOI: 10.1038/s41598-020-64487-2 |
0.443 |
|
| 2019 |
Rajala A, Rajala RVS. A Non-canonical rhodopsin-mediated insulin receptor signaling pathway in retinal photoreceptor neurons. Cell Biology International. PMID 31889373 DOI: 10.1002/cbin.11299 |
0.456 |
|
| 2018 |
Rajala A, Wang Y, Soni K, Rajala RVS. Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration. Cell Death & Disease. 9: 737. PMID 29970877 DOI: 10.1038/s41419-018-0712-9 |
0.466 |
|
| 2018 |
Rajala RVS, Rajala A. Redundant and Nonredundant Functions of Akt Isoforms in the Retina. Advances in Experimental Medicine and Biology. 1074: 585-591. PMID 29721991 DOI: 10.1007/978-3-319-75402-4_71 |
0.626 |
|
| 2018 |
Rajala A, Wang Y, Rajala RVS. Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice. Advances in Experimental Medicine and Biology. 1074: 491-497. PMID 29721981 DOI: 10.1007/978-3-319-75402-4_61 |
0.64 |
|
| 2018 |
Rajala A, Wang Y, Brush RS, Tsantilas K, Jankowski CSR, Lindsay KJ, Linton JD, Hurley JB, Anderson RE, Rajala RVS. Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell Death & Disease. 9: 240. PMID 29445082 DOI: 10.1038/S41419-018-0296-4 |
0.52 |
|
| 2018 |
Rajala A, Wang Y, Abcouwer SF, Gardner TW, Rajala RVS. Developmental and light regulation of tumor suppressor protein PP2A in the retina. Oncotarget. 9: 1505-1523. PMID 29416710 DOI: 10.18632/oncotarget.23351 |
0.508 |
|
| 2017 |
Chen Q, Qiu F, Zhou K, Matlock HG, Takahashi Y, Rajala RV, Yang Y, Moran E, Ma JX. Pathogenic Role of MicroRNA-21 in Diabetic Retinopathy Through Down-Regulation of PPARα. Diabetes. PMID 28270521 DOI: 10.2337/Db16-1246 |
0.318 |
|
| 2016 |
Rajala RV, Rajala A, Kooker C, Wang Y, Anderson RE. The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina. Scientific Reports. 6: 37727. PMID 27883057 DOI: 10.1038/Srep37727 |
0.437 |
|
| 2016 |
Rajala A, Wang Y, Rajala RV. Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival. Oncotarget. PMID 27391439 DOI: 10.18632/oncotarget.10447 |
0.58 |
|
| 2016 |
Rao KN, Li L, Zhang W, Brush RS, Rajala RV, Khanna H. Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina. Human Molecular Genetics. PMID 26908598 DOI: 10.1093/Hmg/Ddw017 |
0.563 |
|
| 2016 |
Rajala RV, Kanan Y, Anderson RE. Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL. Advances in Experimental Medicine and Biology. 854: 419-24. PMID 26427440 DOI: 10.1007/978-3-319-17121-0_55 |
0.475 |
|
| 2016 |
Azadi S, Brush RS, Anderson RE, Rajala RV. Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina. Advances in Experimental Medicine and Biology. 854: 363-9. PMID 26427433 DOI: 10.1007/978-3-319-17121-0_48 |
0.33 |
|
| 2015 |
Rajala RV, Ranjo-Bishop M, Wang Y, Rajala A, Anderson RE. The p110α isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival. Biochimie. 112: 35-40. PMID 25742742 DOI: 10.1016/J.Biochi.2015.02.018 |
0.556 |
|
| 2015 |
Gupta VK, Rajala A, Rajala RVS. Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells Cell Communication and Signaling : Ccs. 13: 7. PMID 25644171 DOI: 10.1186/s12964-015-0087-9 |
0.428 |
|
| 2015 |
Woodruff ML, Rajala A, Fain GL, Rajala RV. Effect of knocking down the insulin receptor on mouse rod responses. Scientific Reports. 5: 7858. PMID 25598343 DOI: 10.1038/srep07858 |
0.33 |
|
| 2015 |
Zulliger R, Naash MI, Rajala RV, Molday RS, Azadi S. Impaired association of retinal degeneration-3 with guanylate cyclase-1 and guanylate cyclase-activating protein-1 leads to leber congenital amaurosis-1. The Journal of Biological Chemistry. 290: 3488-99. PMID 25477517 DOI: 10.1074/Jbc.M114.616656 |
0.327 |
|
| 2014 |
Rajala RV, Rajala A, Morris AJ, Anderson RE. Phosphoinositides: minor lipids make a major impact on photoreceptor cell functions. Scientific Reports. 4: 5463. PMID 24964953 DOI: 10.1038/Srep05463 |
0.415 |
|
| 2014 |
Woodruff ML, Rajala A, Fain GL, Rajala RV. Modulation of mouse rod photoreceptor responses by Grb14 protein. The Journal of Biological Chemistry. 289: 358-64. PMID 24273167 DOI: 10.1074/jbc.M113.517045 |
0.318 |
|
| 2013 |
Rajala RV, Basavarajappa DK, Dighe R, Rajala A. Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation. Cell Communication and Signaling : Ccs. 11: 96. PMID 24350791 DOI: 10.1186/1478-811X-11-96 |
0.512 |
|
| 2013 |
Rajala A, Gupta VK, Anderson RE, Rajala RV. Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Mitochondrion. 13: 566-76. PMID 23993956 DOI: 10.1016/J.Mito.2013.08.005 |
0.51 |
|
| 2013 |
Rajala A, Dighe R, Agbaga MP, Anderson RE, Rajala RV. Insulin receptor signaling in cones. The Journal of Biological Chemistry. 288: 19503-15. PMID 23673657 DOI: 10.1074/Jbc.M113.469064 |
0.658 |
|
| 2013 |
Rajala A, Dilly AK, Rajala RV. Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina. Cell Communication and Signaling : Ccs. 11: 20. PMID 23521888 DOI: 10.1186/1478-811X-11-20 |
0.397 |
|
| 2012 |
Basavarajappa DK, Gupta VK, Rajala RV. Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases. Advances in Experimental Medicine and Biology. 723: 829-34. PMID 22183413 DOI: 10.1007/978-1-4614-0631-0_106 |
0.344 |
|
| 2011 |
Basavarajappa DK, Gupta VK, Dighe R, Rajala A, Rajala RV. Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14. Molecular and Cellular Biology. 31: 3975-87. PMID 21791607 DOI: 10.1128/MCB.05659-11 |
0.464 |
|
| 2011 |
Ivanovic I, Allen DT, Dighe R, Le YZ, Anderson RE, Rajala RV. Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. Investigative Ophthalmology & Visual Science. 52: 6355-62. PMID 21730346 DOI: 10.1167/Iovs.10-7138 |
0.605 |
|
| 2011 |
Ivanovic I, Anderson RE, Le YZ, Fliesler SJ, Sherry DM, Rajala RV. Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration. Investigative Ophthalmology & Visual Science. 52: 3775-83. PMID 21398281 DOI: 10.1167/Iovs.10-7139 |
0.616 |
|
| 2011 |
Huang Z, Anderson RE, Cao W, Wiechmann AF, Rajala RV. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II α phosphatidylinositol-5-phosphate 4-kinase. Neurochemical Research. 36: 627-35. PMID 20204506 DOI: 10.1007/S11064-010-0146-Y |
0.374 |
|
| 2010 |
Rajala RV, Anderson RE. Rhodopsin-regulated insulin receptor signaling pathway in rod photoreceptor neurons. Molecular Neurobiology. 42: 39-47. PMID 20407846 DOI: 10.1007/S12035-010-8130-8 |
0.606 |
|
| 2010 |
Kanan Y, Matsumoto H, Song H, Sokolov M, Anderson RE, Rajala RV. Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. Journal of Neurochemistry. 113: 477-88. PMID 20089132 DOI: 10.1111/J.1471-4159.2010.06609.X |
0.554 |
|
| 2010 |
Rajala RV, Tanito M, Neel BG, Rajala A. Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. The Journal of Biological Chemistry. 285: 8894-904. PMID 20061388 DOI: 10.1074/jbc.M109.070854 |
0.587 |
|
| 2010 |
Rajala RV. Phosphoinositide 3-kinase signaling in the vertebrate retina. Journal of Lipid Research. 51: 4-22. PMID 19638643 DOI: 10.1194/jlr.R000232 |
0.433 |
|
| 2009 |
Rajala RV, Rajala A, Brush RS, Rotstein NP, Politi LE. Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors. Journal of Neurochemistry. 110: 1648-60. PMID 19575708 DOI: 10.1111/j.1471-4159.2009.06262.x |
0.47 |
|
| 2009 |
Rajala RV, Rajala A. Cytoskeletal components enhance the autophosphorylation of retinal insulin receptor. Chemico-Biological Interactions. 180: 245-53. PMID 19497423 DOI: 10.1016/j.cbi.2009.03.010 |
0.544 |
|
| 2009 |
Rajala A, Daly RJ, Tanito M, Allen DT, Holt LJ, Lobanova ES, Arshavsky VY, Rajala RV. Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry. 48: 5563-72. PMID 19438210 DOI: 10.1021/Bi9000062 |
0.53 |
|
| 2009 |
Rajala RV, Ivanovic I, Dilly AK. Retinal insulin receptor signaling in hyperosmotic stress. Vitamins and Hormones. 80: 583-612. PMID 19251051 DOI: 10.1016/S0083-6729(08)00620-1 |
0.578 |
|
| 2009 |
Rajala RV, Wiskur B, Tanito M, Callegan M, Rajala A. Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Investigative Ophthalmology & Visual Science. 50: 1033-40. PMID 19029027 DOI: 10.1167/Iovs.08-2851 |
0.528 |
|
| 2008 |
Rajala RV. Phospho-Site-Specific Antibody Microarray to Study the State of Protein Phosphorylation in the Retina. Journal of Proteomics & Bioinformatics. 1: 242. PMID 20151040 DOI: 10.4172/jpb.1000031 |
0.544 |
|
| 2008 |
Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV. Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides. Journal of Neurochemistry. 107: 1382-97. PMID 18823366 DOI: 10.1111/J.1471-4159.2008.05707.X |
0.401 |
|
| 2008 |
Dilly AK, Rajala RV. Insulin growth factor 1 receptor/PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors. Investigative Ophthalmology & Visual Science. 49: 4765-73. PMID 18566464 DOI: 10.1167/iovs.08-2286 |
0.484 |
|
| 2008 |
Rajala A, Tanito M, Le YZ, Kahn CR, Rajala RV. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. The Journal of Biological Chemistry. 283: 19781-92. PMID 18480052 DOI: 10.1074/Jbc.M802374200 |
0.655 |
|
| 2007 |
Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV. G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. The Journal of Biological Chemistry. 282: 9865-73. PMID 17272282 DOI: 10.1074/Jbc.M608845200 |
0.591 |
|
| 2007 |
Li G, Anderson RE, Tomita H, Adler R, Liu X, Zack DJ, Rajala RV. Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 203-11. PMID 17202487 DOI: 10.1523/Jneurosci.0445-06.2007 |
0.612 |
|
| 2005 |
Rajala RV, Chan MD, Rajala A. Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling. Biochemistry. 44: 15461-71. PMID 16300394 DOI: 10.1021/bi0513148 |
0.457 |
|
| 2005 |
Rajala MS, Rajala RV, Astley RA, Butt AL, Chodosh J. Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation. Journal of Virology. 79: 12332-41. PMID 16160160 DOI: 10.1128/Jvi.79.19.12332-12341.2005 |
0.304 |
|
| 2005 |
Rajala RV, Chan MD. Identification of a NPXY motif in growth factor receptor-bound protein 14 (Grb14) and its interaction with the phosphotyrosine-binding (PTB) domain of IRS-1. Biochemistry. 44: 7929-35. PMID 15924411 DOI: 10.1021/bi0500271 |
0.431 |
|
| 2004 |
Rajala RVS, McClellan ME, Chan MD, Tsiokas L, Anderson RE. Interaction of the Retinal Insulin Receptor β-Subunit with the P85 Subunit of Phosphoinositide 3-Kinase Biochemistry. 43: 5637-5650. PMID 15134438 DOI: 10.1021/Bi035913V |
0.477 |
|
| 2004 |
Yu X, Rajala RV, McGinnis JF, Li F, Anderson RE, Yan X, Li S, Elias RV, Knapp RR, Zhou X, Cao W. Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. The Journal of Biological Chemistry. 279: 13086-94. PMID 14711819 DOI: 10.1074/Jbc.M313283200 |
0.543 |
|
| 2003 |
Rajala RVS, Anderson RE. Light Regulation of the Insulin Receptor in the Retina Molecular Neurobiology. 28: 123-138. PMID 14576451 DOI: 10.1385/Mn:28:2:123 |
0.485 |
|
| 2002 |
Rajala RV, McClellan ME, Ash JD, Anderson RE. In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. The Journal of Biological Chemistry. 277: 43319-26. PMID 12213821 DOI: 10.1074/Jbc.M206355200 |
0.546 |
|
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