☰

Kurtis E. Bachman, Ph.D. - Publications

Affiliations: 
2001 Johns Hopkins University, Baltimore, MD 
Area:
Molecular Biology, Genetics, Cell Biology
Tree Info Grants Similar researchers PubMed Report error

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bhandari YR, Krishna V, Powers R, Parmar S, Thursby SJ, Gupta E, Kulak O, Gokare P, Reumers J, Van Wesenbeeck L, Bachman KE, Baylin SB, Easwaran H. Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 120: e2301536120. PMID 37487069 DOI: 10.1073/pnas.2301536120  0.597
2019 Travers M, Brown SM, Dunworth M, Holbert CE, Wiehagen KR, Bachman KE, Foley JR, Stone ML, Baylin SB, Casero RA, Zahnow CA. DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer. Cancer Research. PMID 31088836 DOI: 10.1158/0008-5472.Can-18-4018  0.434
2018 Stone ML, Chiappinelli KB, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, et al. Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic. Proceedings of the National Academy of Sciences of the United States of America. PMID 30181297 DOI: 10.1073/Pnas.1811015115  0.532
2017 Stone ML, Chiappinelli KB, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, et al. Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden. Proceedings of the National Academy of Sciences of the United States of America. PMID 29203668 DOI: 10.1073/Pnas.1712514114  0.486
2014 Liu L, Shi H, Bleam MR, Zhang V, Zou J, Jing J, Bachman KE, Motwani M, Orford KW, Hoos A. Antitumor effects of dabrafenib, trametinib, and panitumumab as single agents and in combination in BRAF-mutant colorectal carcinoma (CRC) models. Journal of Clinical Oncology. 32: 3513-3513. DOI: 10.1200/Jco.2014.32.15_Suppl.3513  0.333
2013 Hou W, Qin X, Zhu X, Fei M, Liu P, Liu L, Moon H, Zhang P, Greshock J, Bachman KE, Ye BC, Wang H, Zang CY. Lapatinib inhibits the growth of esophageal squamous cell carcinoma and synergistically interacts with 5-fluorouracil in patient-derived xenograft models. Oncology Reports. 30: 707-14. PMID 23708506 DOI: 10.3892/Or.2013.2500  0.308
2012 van den Heuvel AP, Jing J, Wooster RF, Bachman KE. Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth. Cancer Biology & Therapy. 13: 1185-94. PMID 22892846 DOI: 10.4161/Cbt.21348  0.421
2012 Higgins MJ, Jelovac D, Barnathan E, Blair B, Slater S, Powers P, Zorzi J, Jeter SC, Oliver GR, Fetting J, Emens L, Riley C, Stearns V, Diehl F, Angenendt P, ... ... Bachman KE, et al. Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3462-9. PMID 22421194 DOI: 10.1158/1078-0432.Ccr-11-2696  0.361
2012 Jing J, Greshock J, Holbrook JD, Gilmartin A, Zhang X, McNeil E, Conway T, Moy C, Laquerre S, Bachman K, Wooster R, Degenhardt Y. Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212. Molecular Cancer Therapeutics. 11: 720-9. PMID 22169769 DOI: 10.1158/1535-7163.Mct-11-0505  0.384
2012 Heiser LM, Sadanandam A, Kuo WL, Benz SC, Goldstein TC, Ng S, Gibb WJ, Wang NJ, Ziyad S, Tong F, Bayani N, Hu Z, Billig JI, Dueregger A, Lewis S, ... ... Bachman KE, et al. Subtype and pathway specific responses to anticancer compounds in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: 2724-9. PMID 22003129 DOI: 10.1073/Pnas.1018854108  0.355
2011 Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir AM, Gustin JP, Cidado J, Wang GM, ... ... Bachman KE, et al. Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 17773-8. PMID 21987798 DOI: 10.1073/Pnas.1110969108  0.414
2011 Moy C, Oleykowski CA, Plant R, Greshock J, Jing J, Bachman K, Hardwicke MA, Wooster R, Degenhardt Y. High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916. Journal of Translational Medicine. 9: 110. PMID 21762492 DOI: 10.1186/1479-5876-9-110  0.352
2011 Moy C, Aziz MU, Greshock J, Szabo S, McNeil E, Jing J, Conway T, Degenhardt Y, Wooster R, Bachman K. Mutation and copy number detection in human cancers using a custom genotyping assay. Genomics. 98: 296-301. PMID 21600279 DOI: 10.1016/J.Ygeno.2011.04.008  0.396
2010 Degenhardt Y, Greshock J, Laquerre S, Gilmartin AG, Jing J, Richter M, Zhang X, Bleam M, Halsey W, Hughes A, Moy C, Liu-Sullivan N, Powers S, Bachman K, Jackson J, et al. Sensitivity of cancer cells to Plk1 inhibitor GSK461364A is associated with loss of p53 function and chromosome instability. Molecular Cancer Therapeutics. 9: 2079-89. PMID 20571075 DOI: 10.1158/1535-7163.Mct-10-0095  0.426
2010 Weiss MB, Vitolo MI, Mohseni M, Rosen DM, Denmeade SR, Park BH, Weber DJ, Bachman KE. Deletion of p53 in human mammary epithelial cells causes chromosomal instability and altered therapeutic response. Oncogene. 29: 4715-24. PMID 20562907 DOI: 10.1038/Onc.2010.220  0.413
2010 Greshock J, Bachman KE, Degenhardt YY, Jing J, Wen YH, Eastman S, McNeil E, Moy C, Wegrzyn R, Auger K, Hardwicke MA, Wooster R. Molecular target class is predictive of in vitro response profile. Cancer Research. 70: 3677-86. PMID 20406975 DOI: 10.1158/0008-5472.Can-09-3788  0.39
2010 Wooster R, Bachman KE. Catalogue, cause, complexity and cure; the many uses of cancer genome sequence. Current Opinion in Genetics & Development. 20: 336-41. PMID 20382522 DOI: 10.1016/J.Gde.2010.03.007  0.38
2009 Higgins MJ, Abukhdeir AM, Gustin J, Vitolo MI, Bachman KE, Park BH. Preclinical study of lithium sensitivity in human breast PTEN knock out cell lines. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: e14641. PMID 27964232 DOI: 10.1200/Jco.2009.27.15_Suppl.E14641  0.402
2009 Vitolo MI, Weiss MB, Szmacinski M, Tahir K, Waldman T, Park BH, Martin SS, Weber DJ, Bachman KE. Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. Cancer Research. 69: 8275-83. PMID 19843859 DOI: 10.1158/0008-5472.Can-09-1067  0.435
2009 Gustin JP, Karakas B, Weiss MB, Abukhdeir AM, Lauring J, Garay JP, Cosgrove D, Tamaki A, Konishi H, Konishi Y, Mohseni M, Wang G, Rosen DM, Denmeade SR, Higgins MJ, ... ... Bachman KE, et al. Knockin of mutant PIK3CA activates multiple oncogenic pathways. Proceedings of the National Academy of Sciences of the United States of America. 106: 2835-40. PMID 19196980 DOI: 10.1073/Pnas.0813351106  0.43
2009 Degenhardt YY, Zhang X, Moy C, Conway T, Mcneil L, Jing J, Greshock J, Wegrzyn R, Yin H, Mousses S, Wooster R, Bachman K. Abstract B173: Synergistic interaction between CENP‐E inhibitor GSK923295 and MEK inhibitor GSK1120212 Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B173  0.434
2009 Greshock J, Hardwicke MA, Conway T, Degenhardt Y, Cartee L, Moy C, Lager J, Wooster R, Bachman K. Abstract B140: In vitro sensitivity profiling identifies selectively responsive tumor types and molecular subtypes to the PI3K inhibitor GSK2126458 Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B140  0.438
2008 Zhong S, Chen X, Zhu X, Dziegielewska B, Bachman KE, Ellenberger T, Ballin JD, Wilson GM, Tomkinson AE, MacKerell AD. Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design Journal of Medicinal Chemistry. 51: 4553-4562. PMID 18630893 DOI: 10.1021/Jm8001668  0.385
2008 Abukhdeir AM, Vitolo MI, Argani P, De Marzo AM, Karakas B, Konishi H, Gustin JP, Lauring J, Garay JP, Pendleton C, Konishi Y, Blair BG, Brenner K, Garrett-Mayer E, Carraway H, ... Bachman KE, et al. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proceedings of the National Academy of Sciences of the United States of America. 105: 288-93. PMID 18162533 DOI: 10.1073/Pnas.0710887105  0.392
2007 Konishi H, Karakas B, Abukhdeir AM, Lauring J, Gustin JP, Garay JP, Konishi Y, Gallmeier E, Bachman KE, Park BH. Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation. Cancer Research. 67: 8460-7. PMID 17875684 DOI: 10.1158/0008-5472.Can-07-0108  0.342
2007 Karakas B, Weeraratna AT, Abukhdeir AM, Konishi H, Gustin JP, Vitolo MI, Bachman KE, Park BH. P21 gene knock down does not identify genetic effectors seen with gene knock out. Cancer Biology & Therapy. 6: 1025-30. PMID 17611398 DOI: 10.4161/Cbt.6.7.4202  0.397
2007 Vitolo MI, Anglin IE, Mahoney WM, Renoud KJ, Gartenhaus RB, Bachman KE, Passaniti A. The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformation. Cancer Biology & Therapy. 6: 856-63. PMID 17438369 DOI: 10.4161/Cbt.6.6.4241  0.422
2007 Gallmeier E, Hucl T, Brody JR, Dezentje DA, Tahir K, Kasparkova J, Brabec V, Bachman KE, Kern SE. High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells. Cancer Research. 67: 2169-77. PMID 17332347 DOI: 10.1158/0008-5472.Can-06-2711  0.407
2007 Weiss MB, Vitolo MI, Baerenfaller K, Marra G, Park BH, Bachman KE. Persistent mismatch repair deficiency following targeted correction of hMLH1. Cancer Gene Therapy. 14: 98-104. PMID 17082796 DOI: 10.1038/Sj.Cgt.7700997  0.347
2006 Reinert LS, Shi B, Nandi S, Mazan-Mamczarz K, Vitolo M, Bachman KE, He H, Gartenhaus RB. MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles. Cancer Research. 66: 8994-9001. PMID 16982740 DOI: 10.1158/0008-5472.Can-06-1999  0.308
2006 Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, ... ... Bachman KE, et al. The consensus coding sequences of human breast and colorectal cancers Science. 314: 268-274. PMID 16959974 DOI: 10.1126/science.1133427  0.324
2006 Abukhdeir AM, Blair BG, Brenner K, Karakas B, Konishi H, Lim J, Sahasranaman V, Huang Y, Keen J, Davidson N, Vitolo MI, Bachman KE, Park BH. Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells. Breast Cancer Research and Treatment. 99: 23-33. PMID 16541319 DOI: 10.1007/S10549-006-9177-0  0.34
2006 Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers British Journal of Cancer. 94: 455-459. PMID 16449998 DOI: 10.1038/Sj.Bjc.6602970  0.396
2006 Jair KW, Bachman KE, Suzuki H, Ting AH, Rhee I, Yen RW, Baylin SB, Schuebel KE. De novo CpG island methylation in human cancer cells. Cancer Research. 66: 682-92. PMID 16423997 DOI: 10.1158/0008-5472.Can-05-1980  0.745
2005 Bachman KE, Sager J, Cheong I, Catto M, Bardelli A, Park BH, Vogelstein B, Carotti A, Kinzler KW, Lengauer C. Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells Molecular Cancer Therapeutics. 4: 1026-1030. PMID 15956261 DOI: 10.1158/1535-7163.Mct-05-0038  0.405
2004 Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, Peters BA, Velculescu VE, Park BH. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biology & Therapy. 3: 772-5. PMID 15254419 DOI: 10.4161/Cbt.3.8.994  0.375
2003 Reese BE, Bachman KE, Baylin SB, Rountree MR. The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1. Molecular and Cellular Biology. 23: 3226-36. PMID 12697822 DOI: 10.1128/Mcb.23.9.3226-3236.2003  0.616
2003 Bachman KE, Park BH, Rhee I, Rajagopalan H, Herman JG, Baylin SB, Kinzler KW, Vogelstein B. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene Cancer Cell. 3: 89-95. PMID 12559178 DOI: 10.1016/S1535-6108(02)00234-9  0.652
2002 Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 416: 552-6. PMID 11932749 DOI: 10.1038/416552A  0.695
2002 Galm O, Rountree MR, Bachman KE, Jair KW, Baylin SB, Herman JG. Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density. Genome Research. 12: 153-7. PMID 11779840 DOI: 10.1101/Gr.202501  0.61
2001 Bachman KE, Rountree MR, Baylin SB. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. The Journal of Biological Chemistry. 276: 32282-7. PMID 11427539 DOI: 10.1074/Jbc.M104661200  0.611
2001 Rountree MR, Bachman KE, Herman JG, Baylin SB. DNA methylation, chromatin inheritance, and cancer. Oncogene. 20: 3156-65. PMID 11420732 DOI: 10.1038/Sj.Onc.1204339  0.686
2001 Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Human Molecular Genetics. 10: 687-92. PMID 11257100 DOI: 10.1093/Hmg/10.7.687  0.692
2000 Dang DT, Bachman KE, Mahatan CS, Dang LH, Giardiello FM, Yang VW. Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. Febs Letters. 476: 203-7. PMID 10913614 DOI: 10.1016/S0014-5793(00)01727-0  0.409
2000 Rountree MR, Bachman KE, Baylin SB. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Genetics. 25: 269-77. PMID 10888872 DOI: 10.1038/77023  0.61
1999 Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Research. 59: 798-802. PMID 10029065  0.592
1999 Cameron EE, Bachman KE, Myöhänen S, Herman JG, Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Genetics. 21: 103-7. PMID 9916800 DOI: 10.1038/5047  0.73
Show low-probability matches.