| Year |
Citation |
Score |
| 2020 |
Annaert W, Kaether C. Bring it back, bring it back, don't take it away from me - the sorting receptor RER1. Journal of Cell Science. 133. PMID 32873699 DOI: 10.1242/Jcs.231423 |
0.407 |
|
| 2020 |
Escamilla-Ayala AA, Sannerud R, Mondin M, Poersch K, Vermeire W, Paparelli L, Berlage C, Koenig M, Chavez-Gutierrez L, Ulbrich MH, Munck S, Mizuno H, Annaert W. Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface. Elife. 9. PMID 32631487 DOI: 10.7554/Elife.56679 |
0.417 |
|
| 2020 |
Escamilla-Ayala A, Wouters R, Sannerud R, Annaert W. Contribution of the Presenilins in the cell biology, structure and function of γ-secretase. Seminars in Cell & Developmental Biology. PMID 32146031 DOI: 10.1016/J.Semcdb.2020.02.005 |
0.503 |
|
| 2020 |
van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquière B, et al. ATP13A2 deficiency disrupts lysosomal polyamine export. Nature. PMID 31996848 DOI: 10.1038/S41586-020-1968-7 |
0.37 |
|
| 2019 |
Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, et al. Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export. Nature Communications. 10: 3521. PMID 31387993 DOI: 10.1038/S41467-019-11425-0 |
0.343 |
|
| 2019 |
Van Acker ZP, Bretou M, Annaert W. Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors. Molecular Neurodegeneration. 14: 20. PMID 31159836 DOI: 10.1186/S13024-019-0323-7 |
0.411 |
|
| 2019 |
Bissig C, Croisé P, Heiligenstein X, Hurbain I, Lenk GM, Kaufman E, Sannerud R, Annaert W, Meisler MH, Weisman LS, Raposo G, van Niel G. PIKfyve complex regulates early melanosome homeostasis required for physiological amyloid formation. Journal of Cell Science. PMID 30709920 DOI: 10.1242/Jcs.229500 |
0.425 |
|
| 2018 |
Verheijen BM, Stevens JAA, Gentier RJG, van 't Hekke CD, van den Hove DLA, Hermes DJHP, Steinbusch HWM, Ruijter JM, Grimm MOW, Haupenthal VJ, Annaert W, Hartmann T, van Leeuwen FW. Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model. Neurobiology of Aging. 72: 62-71. PMID 30216939 DOI: 10.1016/J.Neurobiolaging.2018.08.011 |
0.43 |
|
| 2018 |
Mishev K, Lu Q, Denoo B, Peurois F, Dejonghe W, Hullaert J, De Rycke RM, Boeren S, Bretou M, De Munck S, Sharma IS, Goodman K, Kalinowska K, Storme V, Nguyen L, ... ... Annaert W, et al. Nonselective chemical inhibition of Sec7 domain-containing ARF GEFs in Arabidopsis. The Plant Cell. PMID 30018157 DOI: 10.1105/Tpc.18.00145 |
0.41 |
|
| 2017 |
Tharkeshwar AK, Gevaert K, Annaert W. Organellar Omics-A Reviving Strategy to Untangle the Biomolecular Complexity of the Cell. Proteomics. PMID 29125683 DOI: 10.1002/Pmic.201700113 |
0.352 |
|
| 2017 |
Declercq J, Ramos-Molina B, Sannerud R, Brouwers B, Pruniau VPEG, Meulemans S, Plets E, Annaert W, Creemers JWM. Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines. European Journal of Cell Biology. 96: 432-439. PMID 28413120 DOI: 10.1016/J.Ejcb.2017.03.010 |
0.317 |
|
| 2017 |
Guix FX, Sannerud R, Berditchevski F, Arranz AM, Horré K, Snellinx A, Thathiah A, Saido T, Saito T, Rajesh S, Overduin M, Kumar-Singh S, Radaelli E, Corthout N, Colombelli J, ... ... Annaert W, et al. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Molecular Neurodegeneration. 12: 25. PMID 28279219 DOI: 10.1186/S13024-017-0165-0 |
0.42 |
|
| 2017 |
Tharkeshwar AK, Trekker J, Vermeire W, Pauwels J, Sannerud R, Priestman DA, Te Vruchte D, Vints K, Baatsen P, Decuypere JP, Lu H, Martin S, Vangheluwe P, Swinnen JV, Lagae L, ... ... Annaert W, et al. A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency. Scientific Reports. 7: 41408. PMID 28134274 DOI: 10.1038/Srep41408 |
0.36 |
|
| 2017 |
Sannerud R, Annaert W. Bin1 and CD2AP polarize Aβ generation in neurons. Embo Reports. 18: 5-7. PMID 27993940 DOI: 10.15252/Embr.201643634 |
0.384 |
|
| 2016 |
Paparelli L, Corthout N, Pavie B, Wakefield DL, Sannerud R, Jovanovic-Talisman T, Annaert W, Munck S. Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane. Plos Computational Biology. 12: e1005095. PMID 27603951 DOI: 10.1371/Journal.Pcbi.1005095 |
0.326 |
|
| 2016 |
Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, ... ... Annaert W, et al. Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool. Cell. PMID 27293189 DOI: 10.1016/J.Cell.2016.05.020 |
0.463 |
|
| 2016 |
Paparelli L, Corthout N, Pavie B, Annaert W, Munck S. Analyzing Protein Clusters on the Plasma Membrane: Application of Spatial Statistical Analysis Methods on Super-Resolution Microscopy Images. Advances in Anatomy, Embryology, and Cell Biology. 219: 95-122. PMID 27207364 DOI: 10.1007/978-3-319-28549-8_4 |
0.35 |
|
| 2016 |
Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, Becker-Pauly C. Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains. Biological Chemistry. PMID 27180357 DOI: 10.1515/Hsz-20-2016-0126 |
0.342 |
|
| 2015 |
Gijs HL, Willemarck N, Vanderhoydonc F, Khan NA, Dehairs J, Derua R, Waelkens E, Taketomi Y, Murakami M, Agostinis P, Annaert W, Swinnen JV. Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3. Molecular Biology of the Cell. 26: 2321-32. PMID 25904332 DOI: 10.1091/Mbc.E14-10-1472 |
0.39 |
|
| 2015 |
Peric A, Annaert W. Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction? Acta Neuropathologica. 129: 363-81. PMID 25556159 DOI: 10.1007/S00401-014-1379-7 |
0.418 |
|
| 2015 |
Couceiro JR, Gallardo R, De Smet F, De Baets G, Baatsen P, Annaert W, Roose K, Saelens X, Schymkowitz J, Rousseau F. Sequence-dependent internalization of aggregating peptides. The Journal of Biological Chemistry. 290: 242-58. PMID 25391649 DOI: 10.1074/Jbc.M114.586636 |
0.369 |
|
| 2013 |
Jurisch-Yaksi N, Annaert W. Protein quality control by Rer1p in the early secretory pathway: from mechanism to implication in Alzheimer's disease. Alzheimer's Research & Therapy. 5: 61. PMID 24314151 DOI: 10.1186/Alzrt227 |
0.742 |
|
| 2013 |
Jurisch-Yaksi N, Sannerud R, Annaert W. A fast growing spectrum of biological functions of γ-secretase in development and disease. Biochimica Et Biophysica Acta. 1828: 2815-27. PMID 24099003 DOI: 10.1016/J.Bbamem.2013.04.016 |
0.728 |
|
| 2013 |
Jurisch-Yaksi N, Rose AJ, Lu H, Raemaekers T, Munck S, Baatsen P, Baert V, Vermeire W, Scales SJ, Verleyen D, Vandepoel R, Tylzanowski P, Yaksi E, de Ravel T, Yost HJ, ... ... Annaert W, et al. Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels. The Journal of Cell Biology. 200: 709-20. PMID 23479743 DOI: 10.1083/Jcb.201208175 |
0.712 |
|
| 2012 |
Raemaekers T, Peric A, Baatsen P, Sannerud R, Declerck I, Baert V, Michiels C, Annaert W. ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation. The Embo Journal. 31: 3252-69. PMID 22781129 DOI: 10.1038/Emboj.2012.182 |
0.356 |
|
| 2012 |
Coen K, Flannagan RS, Baron S, Carraro-Lacroix LR, Wang D, Vermeire W, Michiels C, Munck S, Baert V, Sugita S, Wuytack F, Hiesinger PR, Grinstein S, Annaert W. Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. The Journal of Cell Biology. 198: 23-35. PMID 22753898 DOI: 10.1083/Jcb.201201076 |
0.363 |
|
| 2012 |
Gordts PL, Bartelt A, Nilsson SK, Annaert W, Christoffersen C, Nielsen LB, Heeren J, Roebroek AJ. Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice. Plos One. 7: e38330. PMID 22701627 DOI: 10.1371/Journal.Pone.0038330 |
0.306 |
|
| 2012 |
Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, Annaert W, Moechars D, Mercken M, Gevaert K, Gevaer K, De Strooper B. The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. The Journal of Biological Chemistry. 287: 25927-40. PMID 22692213 DOI: 10.1074/Jbc.M112.377465 |
0.371 |
|
| 2012 |
Esselens C, Sannerud R, Gallardo R, Baert V, Kaden D, Serneels L, De Strooper B, Rousseau F, Multhaup G, Schymkowitz J, Langedijk JP, Annaert W. Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3765-78. PMID 22661005 DOI: 10.1096/Fj.11-201368 |
0.379 |
|
| 2012 |
Rajendran L, Annaert W. Membrane trafficking pathways in Alzheimer's disease. Traffic (Copenhagen, Denmark). 13: 759-70. PMID 22269004 DOI: 10.1111/j.1600-0854.2012.01332.x |
0.394 |
|
| 2012 |
Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, Rubio N, Firczuk M, Mathieu C, Roebroek AJ, Annaert W, Golab J, de Witte P, Vandenabeele P, Agostinis P. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. The Embo Journal. 31: 1062-79. PMID 22252128 DOI: 10.1038/Emboj.2011.497 |
0.32 |
|
| 2012 |
Annaert W. Sorting out the cell biology of Alzheimer’s disease: focus on BACE1 and APP. Molecular Neurodegeneration. 7: 1-2. DOI: 10.1186/1750-1326-7-S1-L6 |
0.435 |
|
| 2011 |
Thimiri Govinda Raj DB, Ghesquière B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, ... Annaert W, et al. A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Molecular Systems Biology. 7: 541. PMID 22027552 DOI: 10.1038/Msb.2011.74 |
0.337 |
|
| 2011 |
Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W. ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proceedings of the National Academy of Sciences of the United States of America. 108: E559-68. PMID 21825135 DOI: 10.1073/Pnas.1100745108 |
0.462 |
|
| 2011 |
Zhou L, Chávez-Gutiérrez L, Bockstael K, Sannerud R, Annaert W, May PC, Karran E, De Strooper B. Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. The Journal of Biological Chemistry. 286: 8677-87. PMID 21209097 DOI: 10.1074/Jbc.M110.194860 |
0.316 |
|
| 2011 |
Reynders E, Foulquier F, Annaert W, Matthijs G. How Golgi glycosylation meets and needs trafficking: the case of the COG complex. Glycobiology. 21: 853-63. PMID 21112967 DOI: 10.1093/Glycob/Cwq179 |
0.39 |
|
| 2010 |
Coen K, Annaert W. Presenilins: how much more than γ-secretase?! Biochemical Society Transactions. 38: 1474-8. PMID 21118110 DOI: 10.1042/Bst0381474 |
0.505 |
|
| 2010 |
De Strooper B, Annaert W. Novel research horizons for presenilins and γ-secretases in cell biology and disease. Annual Review of Cell and Developmental Biology. 26: 235-60. PMID 20604710 DOI: 10.1146/Annurev-Cellbio-100109-104117 |
0.501 |
|
| 2010 |
Annaert W, De Strooper B. Alzheimer's disease neurons fail the acid test. Cell. 141: 1112-4. PMID 20602994 DOI: 10.1016/J.Cell.2010.06.009 |
0.381 |
|
| 2010 |
Reekmans SM, Pflanzner T, Gordts PL, Isbert S, Zimmermann P, Annaert W, Weggen S, Roebroek AJ, Pietrzik CU. Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis. Cellular and Molecular Life Sciences : Cmls. 67: 135-45. PMID 19856143 DOI: 10.1007/S00018-009-0171-7 |
0.354 |
|
| 2009 |
Laky K, Annaert W, Fowlkes BJ. Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development International Immunology. 21: 1163-1174. PMID 19710207 DOI: 10.1093/intimm/dxp083 |
0.313 |
|
| 2009 |
Reynders E, Foulquier F, Leão Teles E, Quelhas D, Morelle W, Rabouille C, Annaert W, Matthijs G. Golgi function and dysfunction in the first COG4-deficient CDG type II patient. Human Molecular Genetics. 18: 3244-56. PMID 19494034 DOI: 10.1093/Hmg/Ddp262 |
0.347 |
|
| 2009 |
Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B. ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. The Journal of Biological Chemistry. 284: 11738-47. PMID 19213735 DOI: 10.1074/Jbc.M805894200 |
0.471 |
|
| 2009 |
Sannerud R, Annaert W. Trafficking, a key player in regulated intramembrane proteolysis. Seminars in Cell & Developmental Biology. 20: 183-90. PMID 19056506 DOI: 10.1016/J.Semcdb.2008.11.004 |
0.42 |
|
| 2008 |
Spasic D, Annaert W. Building gamma-secretase: the bits and pieces. Journal of Cell Science. 121: 413-20. PMID 18256384 DOI: 10.1242/Jcs.015255 |
0.473 |
|
| 2007 |
Ignoul S, Simaels J, Hermans D, Annaert W, Eggermont J. Human CIC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains Plos One. 2. PMID 17534424 DOI: 10.1371/Journal.Pone.0000474 |
0.381 |
|
| 2007 |
Spasic D, Raemaekers T, Dillen K, Declerck I, Baert V, Serneels L, Füllekrug J, Annaert W. Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway. The Journal of Cell Biology. 176: 629-40. PMID 17325205 DOI: 10.1083/Jcb.200609180 |
0.473 |
|
| 2007 |
Ignoul S, Hermans D, Simaels J, Annaert W, Eggermont J. Human ClC-6 is a lipid raft associated glycoprotein that resides in late endosomes in neuronal cells but not upon overexpression in COS and HeLa cells The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A537 |
0.352 |
|
| 2006 |
Dillen K, Annaert W. A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? International Review of Cytology. 254: 215-300. PMID 17148000 DOI: 10.1016/S0074-7696(06)54005-7 |
0.428 |
|
| 2006 |
Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S, Annaert W. Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. The Journal of Biological Chemistry. 281: 26569-77. PMID 16846981 DOI: 10.1074/Jbc.M600592200 |
0.449 |
|
| 2006 |
Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, et al. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell. 126: 163-75. PMID 16839884 DOI: 10.1016/J.Cell.2006.06.021 |
0.341 |
|
| 2006 |
Foulquier F, Vasile E, Schollen E, Callewaert N, Raemaekers T, Quelhas D, Jaeken J, Mills P, Winchester B, Krieger M, Annaert W, Matthijs G. Conserved oligomeric Golgi complex subunit 1 deficiency reveals a previously uncharacterized congenital disorder of glycosylation type II. Proceedings of the National Academy of Sciences of the United States of America. 103: 3764-9. PMID 16537452 DOI: 10.1073/Pnas.0507685103 |
0.334 |
|
| 2006 |
Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Traffic (Copenhagen, Denmark). 7: 354-64. PMID 16497228 DOI: 10.1111/j.1600-0854.2006.00388.x |
0.333 |
|
| 2005 |
Raemaekers T, Esselens C, Annaert W. Presenilin 1: more than just γ-secretase Biochemical Society Transactions. 33: 559-562. PMID 16042544 DOI: 10.1042/Bst0330559 |
0.452 |
|
| 2005 |
Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 1719-24. PMID 15665098 DOI: 10.1073/Pnas.0408901102 |
0.43 |
|
| 2004 |
Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiology of Disease. 17: 260-72. PMID 15474363 DOI: 10.1016/J.Nbd.2004.08.002 |
0.389 |
|
| 2004 |
Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. The Journal of Cell Biology. 166: 1041-54. PMID 15452145 DOI: 10.1083/Jcb.200406060 |
0.412 |
|
| 2003 |
Schulz JG, Annaert W, Vandekerckhove J, Zimmermann P, De Strooper B, David G. Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling. The Journal of Biological Chemistry. 278: 48651-7. PMID 14504279 DOI: 10.1074/Jbc.M308424200 |
0.464 |
|
| 2003 |
Raemaekers T, Ribbeck K, Beaudouin J, Annaert W, Van Camp M, Stockmans I, Smets N, Bouillon R, Ellenberg J, Carmeliet G. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. The Journal of Cell Biology. 162: 1017-29. PMID 12963707 DOI: 10.1083/Jcb.200302129 |
0.36 |
|
| 2003 |
Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B. Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin. The Journal of Biological Chemistry. 278: 43430-6. PMID 12885769 DOI: 10.1074/Jbc.M306957200 |
0.326 |
|
| 2003 |
Van Gassen G, Annaert W. Amyloid, presenilins, and Alzheimer's disease. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 9: 117-26. PMID 12708616 DOI: 10.1177/1073858403252227 |
0.461 |
|
| 2003 |
Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B. gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. Journal of Cell Science. 116: 1127-36. PMID 12584255 DOI: 10.1242/Jcs.00292 |
0.471 |
|
| 2002 |
Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Human Molecular Genetics. 11: 2615-24. PMID 12354787 DOI: 10.1093/Hmg/11.21.2615 |
0.351 |
|
| 2002 |
Annaert W, De Strooper B. A cell biological perspective on Alzheimer's disease. Annual Review of Cell and Developmental Biology. 18: 25-51. PMID 12142279 DOI: 10.1146/annurev.cellbio.18.020402.142302 |
0.378 |
|
| 2001 |
Sisodia SS, Annaert W, Kim SH, De Strooper B. Gamma-secretase: never more enigmatic. Trends in Neurosciences. 24: S2-6. PMID 11881741 DOI: 10.1016/S0166-2236(00)01987-1 |
0.366 |
|
| 2001 |
Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B. Implication of APP secretases in notch signaling. Journal of Molecular Neuroscience : Mn. 17: 171-81. PMID 11816790 DOI: 10.1385/Jmn:17:2:171 |
0.435 |
|
| 2001 |
Strooper BD, Annaert W. Presenilins and the intramembrane proteolysis of proteins: facts and fiction. Nature Cell Biology. 3. PMID 11584280 DOI: 10.1038/Ncb1001-E221 |
0.426 |
|
| 2001 |
Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. Journal of Neurochemistry. 78: 1168-78. PMID 11553691 |
0.372 |
|
| 2001 |
De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B. Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability. Human Molecular Genetics. 10: 1665-71. PMID 11487570 DOI: 10.1093/Hmg/10.16.1665 |
0.384 |
|
| 2001 |
Dominguez DI, De Strooper B, Annaert W. Secretases as therapeutic targets for the treatment of Alzheimer's disease. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 124-42. PMID 11409035 DOI: 10.3109/13506120109007356 |
0.438 |
|
| 2001 |
De Strooper B, Annaert W. Where Notch and Wnt signaling meet. The presenilin hub. The Journal of Cell Biology. 152: F17-20. PMID 11266476 DOI: 10.1083/Jcb.152.4.F17 |
0.308 |
|
| 2001 |
Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B. Processing of beta-secretase by furin and other members of the proprotein convertase family. The Journal of Biological Chemistry. 276: 4211-7. PMID 11071887 DOI: 10.1074/Jbc.M006947200 |
0.427 |
|
| 2000 |
Annaert W, Cupers P, Saftig P, De Strooper B. Presenilin function in APP processing. Annals of the New York Academy of Sciences. 920: 158-64. PMID 11193144 DOI: 10.1111/J.1749-6632.2000.Tb06917.X |
0.407 |
|
| 2000 |
Annaert W, De Strooper B. Neuronal models to study amyloid precursor protein expression and processing in vitro. Biochimica Et Biophysica Acta. 1502: 53-62. PMID 10899431 DOI: 10.1016/S0925-4439(00)00032-6 |
0.459 |
|
| 2000 |
Gassen GV, Annaert W, Broeckhoven CV. Binding partners of Alzheimer's disease proteins: are they physiologically relevant? Neurobiology of Disease. 7: 135-151. PMID 10860781 DOI: 10.1006/nbdi.2000.0320 |
0.456 |
|
| 2000 |
Scheper W, Zwart R, Van Der Sluijs P, Annaert W, Van Gool WA, Baas F. Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor Human Molecular Genetics. 9: 303-310. PMID 10607841 DOI: 10.1093/HMG/9.2.303 |
0.353 |
|
| 2000 |
Strooper BD, Annaert W. Role of presenilin 1 and presenilin 2 in APP and Notch processing Neurobiology of Aging. 21: 76. DOI: 10.1016/S0197-4580(00)82564-6 |
0.351 |
|
| 1999 |
Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, George-Hyslop PS, Cordell B, Fraser P, De Strooper B. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. The Journal of Cell Biology. 147: 277-94. PMID 10525535 DOI: 10.1083/Jcb.147.2.277 |
0.356 |
|
| 1999 |
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proceedings of the National Academy of Sciences of the United States of America. 96: 11872-7. PMID 10518543 DOI: 10.1073/Pnas.96.21.11872 |
0.377 |
|
| 1999 |
Annaert W, De Strooper B. Presenilins: molecular switches between proteolysis and signal transduction. Trends in Neurosciences. 22: 439-43. PMID 10481190 DOI: 10.1016/S0166-2236(99)01455-1 |
0.47 |
|
| 1999 |
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398: 518-22. PMID 10206645 DOI: 10.1038/19083 |
0.374 |
|
| 1998 |
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391: 387-90. PMID 9450754 DOI: 10.1038/34910 |
0.469 |
|
| 1997 |
Annaert WG, Becker B, Kistner U, Reth M, Jahn R. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. The Journal of Cell Biology. 139: 1397-410. PMID 9396746 DOI: 10.1083/Jcb.139.6.1397 |
0.303 |
|
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