| Year |
Citation |
Score |
| 2024 |
Fritzen L, Wienken K, Wagner L, Kurtyka M, Vogel K, Körbelin J, Weggen S, Fricker G, Pietrzik CU. Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier. Fluids and Barriers of the Cns. 21: 74. PMID 39289695 DOI: 10.1186/s12987-024-00573-1 |
0.582 |
|
| 2024 |
Armbrust F, Bickenbach K, Altmeppen H, Foggetti A, Winkelmann A, Wulff P, Glatzel M, Pietrzik CU, Becker-Pauly C. A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes. Cellular and Molecular Life Sciences : Cmls. 81: 139. PMID 38480559 DOI: 10.1007/s00018-024-05139-w |
0.374 |
|
| 2023 |
Kurth V, Ogorek I, Münch C, Lopez-Rios J, Ousson S, Lehmann S, Nieweg K, Roebroek AJM, Pietrzik CU, Beher D, Weggen S. Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild type PSEN1. The Journal of Biological Chemistry. 104997. PMID 37394008 DOI: 10.1016/j.jbc.2023.104997 |
0.655 |
|
| 2023 |
Klecker PH, Fritzen L, Mazura AD, Weggen S, Pietrzik CU. Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy. Journal of Cellular Biochemistry. PMID 37288821 DOI: 10.1002/jcb.30431 |
0.587 |
|
| 2023 |
Ulku I, Liebsch F, Akerman SC, Schulz JF, Kulic L, Hock C, Pietrzik C, Di Spiezio A, Thinakaran G, Saftig P, Multhaup G. Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis. Scientific Reports. 13: 2216. PMID 36750595 DOI: 10.1038/s41598-023-28846-z |
0.438 |
|
| 2022 |
Mazura AD, Ohler A, Storck SE, Kurtyka M, Scharfenberg F, Weggen S, Becker-Pauly C, Pietrzik CU. PCSK9 acts as a key regulator of Aβ clearance across the blood-brain barrier. Cellular and Molecular Life Sciences : Cmls. 79: 212. PMID 35344086 DOI: 10.1007/s00018-022-04237-x |
0.667 |
|
| 2022 |
Marengo L, Armbrust F, Schoenherr C, Storck SE, Schmitt U, Zampar S, Wirths O, Altmeppen H, Glatzel M, Kaether C, Weggen S, Becker-Pauly C, Pietrzik CU. Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease. Cellular and Molecular Life Sciences : Cmls. 79: 168. PMID 35235058 DOI: 10.1007/s00018-022-04205-5 |
0.666 |
|
| 2021 |
Armbrust F, Bickenbach K, Marengo L, Pietrzik C, Becker-Pauly C. The Swedish dilemma - the almost exclusive use of APPswe-based mouse models impedes adequate evaluation of alternative β-secretases. Biochimica Et Biophysica Acta. Molecular Cell Research. 1869: 119164. PMID 34699873 DOI: 10.1016/j.bbamcr.2021.119164 |
0.371 |
|
| 2021 |
Storck SE, Hartz AMS, Pietrzik CU. The Blood-Brain Barrier in Alzheimer's Disease. Handbook of Experimental Pharmacology. PMID 33580390 DOI: 10.1007/164_2020_418 |
0.317 |
|
| 2020 |
Bres EE, Safina D, Müller J, Bedner P, Yang H, Helluy X, Shchyglo O, Jansen S, Mark MD, Esser A, Steinhäuser C, Herlitze S, Pietrzik CU, Sirko S, Manahan-Vaughan D, et al. Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures. Glia. PMID 32579270 DOI: 10.1002/Glia.23869 |
0.339 |
|
| 2019 |
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, et al. Degradome of soluble ADAM10 and ADAM17 metalloproteases. Cellular and Molecular Life Sciences : Cmls. PMID 31209506 DOI: 10.1007/S00018-019-03184-4 |
0.316 |
|
| 2019 |
Scharfenberg F, Armbrust F, Marengo L, Pietrzik C, Becker-Pauly C. Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding. Cellular and Molecular Life Sciences : Cmls. 76: 3193-3206. PMID 31201463 DOI: 10.1007/S00018-019-03179-1 |
0.414 |
|
| 2019 |
Van Gool B, Storck SE, Reekmans SM, Lechat B, Gordts PLSM, Pradier L, Pietrzik CU, Roebroek AJM. LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease. Molecular Neurobiology. PMID 31004319 DOI: 10.1007/S12035-019-1594-2 |
0.512 |
|
| 2019 |
Peters F, Scharfenberg F, Colmorgen C, Armbrust F, Wichert R, Arnold P, Potempa B, Potempa J, Pietrzik CU, Häsler R, Rosenstiel P, Becker-Pauly C. Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802391R. PMID 30916990 DOI: 10.1096/Fj.201802391R |
0.312 |
|
| 2018 |
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, Wiltfang J, Becker-Pauly C, Beher D, Pietrzik CU, et al. The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. Acta Neuropathologica. PMID 30426203 DOI: 10.1007/S00401-018-1929-5 |
0.691 |
|
| 2018 |
Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU. The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. Brain, Behavior, and Immunity. PMID 30041013 DOI: 10.1016/J.Bbi.2018.07.017 |
0.668 |
|
| 2018 |
Goel P, Jumpertz T, Tichá A, Ogorek I, Mikles DC, Hubalek M, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S. Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29463448 DOI: 10.1016/J.Bmcl.2018.02.017 |
0.594 |
|
| 2018 |
Storck SE, Pietrzik CU. The Blood brain-barrier and its role in Alzheimer’s disease Neuroforum. 24: A197-A205. DOI: 10.1515/Nf-2018-A014 |
0.383 |
|
| 2018 |
Storck SE, Pietrzik CU. Die Blut-Hirn-Schranke und ihre Rolle in der Alzheimer – Krankheit Neuroforum. 24: 287-296. DOI: 10.1515/Nf-2018-0014 |
0.373 |
|
| 2017 |
Goel P, Jumpertz T, Mikles DC, Tichá A, Nguyen MTN, Verhelst S, Hubalek M, Johnson DC, Bachovchin DA, Ogorek I, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S. Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases. Biochemistry. PMID 29185711 DOI: 10.1021/Acs.Biochem.7B01066 |
0.6 |
|
| 2017 |
Storck SE, Pietrzik CU. Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease. Pharmaceutical Research. PMID 28948494 DOI: 10.1007/S11095-017-2267-3 |
0.476 |
|
| 2017 |
Zandl-Lang M, Fanaee-Danesh E, Sun Y, Čančar I, Gali CC, Kober A, Albrecher NM, Tam-Amersdorfer C, Stracke A, Storck S, Saeed A, Stefulj J, Pietrzik C, Wilson MR, Björkhem I, et al. Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells. Biochimica Et Biophysica Acta. PMID 28941799 DOI: 10.1016/J.Bbalip.2017.09.008 |
0.517 |
|
| 2017 |
Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S. Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cellular and Molecular Life Sciences : Cmls. PMID 28799085 DOI: 10.1007/S00018-017-2625-7 |
0.809 |
|
| 2017 |
Steffen J, Krohn M, Schwitlick C, Brüning T, Paarmann K, Pietrzik CU, Biverstål H, Jansone B, Langer O, Pahnke J. Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice. Acta Neuropathologica Communications. 5: 49. PMID 28637503 DOI: 10.1186/S40478-017-0448-2 |
0.46 |
|
| 2017 |
Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S. LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Frontiers in Molecular Neuroscience. 10: 118. PMID 28496400 DOI: 10.3389/fnmol.2017.00118 |
0.728 |
|
| 2017 |
Wild K, August A, Pietrzik CU, Kins S. Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments. Frontiers in Molecular Neuroscience. 10: 21. PMID 28197076 DOI: 10.3389/Fnmol.2017.00021 |
0.445 |
|
| 2016 |
Becker-Pauly C, Pietrzik CU. The Metalloprotease Meprin β Is an Alternative β-Secretase of APP. Frontiers in Molecular Neuroscience. 9: 159. PMID 28105004 DOI: 10.3389/Fnmol.2016.00159 |
0.405 |
|
| 2016 |
Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A, Endres K. Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model. Journal of Alzheimer's Disease : Jad. PMID 28035935 DOI: 10.3233/Jad-160926 |
0.371 |
|
| 2016 |
Becker-Pauly C, Pietrzik CU. Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models. Ebiomedicine. PMID 27396345 DOI: 10.1016/J.Ebiom.2016.06.035 |
0.479 |
|
| 2016 |
Safina D, Schlitt F, Romeo R, Pflanzner T, Pietrzik CU, Narayanaswami V, Edenhofer F, Faissner A. Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation. Glia. PMID 27258849 DOI: 10.1002/Glia.23009 |
0.311 |
|
| 2016 |
Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, Becker-Pauly C. Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains. Biological Chemistry. PMID 27180357 DOI: 10.1515/Hsz-20-2016-0126 |
0.355 |
|
| 2016 |
Schönherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU. Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site. Molecular Neurodegeneration. 11: 19. PMID 26895626 DOI: 10.1186/S13024-016-0084-5 |
0.674 |
|
| 2016 |
Storck S, Vandenbroucke RE, Weggen S, Schwaninger M, Bayer T, Pietrzik CU. O4-11-05: Endothelial-LRP1 Clears Major Amounts of Abeta 1-42 Across the Blood-Brain Barrier Alzheimer's & Dementia. 12: P361-P362. DOI: 10.1016/J.Jalz.2016.06.670 |
0.631 |
|
| 2015 |
Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, ... Pietrzik CU, et al. Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier. The Journal of Clinical Investigation. PMID 26619118 DOI: 10.1172/Jci81108 |
0.682 |
|
| 2015 |
Rabiej VK, Pflanzner T, Wagner T, Götze K, Storck S, Eble JA, Weggen S, Mueller-Klieser W, Pietrzik CU. Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration. Experimental Cell Research. PMID 26610862 DOI: 10.1016/J.Yexcr.2015.11.020 |
0.618 |
|
| 2015 |
Jäckle F, Schmidt F, Wichert R, Arnold P, Prox J, Mangold M, Ohler A, Pietrzik CU, Koudelka T, Tholey A, Gütschow M, Stirnberg M, Becker-Pauly C. Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding. The Biochemical Journal. 470: 91-103. PMID 26251449 DOI: 10.1042/Bj20141417 |
0.39 |
|
| 2015 |
Arnold P, Schmidt F, Prox J, Zunke F, Pietrzik C, Lucius R, Becker-Pauly C. Calcium negatively regulates meprin β activity and attenuates substrate cleavage. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 3549-57. PMID 25957281 DOI: 10.1096/Fj.15-272310 |
0.337 |
|
| 2015 |
Meister S, Storck SE, Hameister E, Behl C, Weggen S, Clement AM, Pietrzik CU. Expression of the ALS-causing variant hSOD1(G93A) leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 1112-21. PMID 25853911 DOI: 10.1038/Jcbfm.2015.57 |
0.6 |
|
| 2014 |
Tucher J, Linke D, Koudelka T, Cassidy L, Tredup C, Wichert R, Pietrzik C, Becker-Pauly C, Tholey A. LC-MS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries. Journal of Proteome Research. 13: 2205-14. PMID 24635658 DOI: 10.1021/Pr401135U |
0.316 |
|
| 2013 |
Meister S, Zlatev I, Stab J, Docter D, Baches S, Stauber RH, Deutsch M, Schmidt R, Ropele S, Windisch M, Langer K, Wagner S, von Briesen H, Weggen S, Pietrzik CU. Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood-brain barrier model. Alzheimer's Research & Therapy. 5: 51. PMID 24280275 DOI: 10.1186/Alzrt225 |
0.654 |
|
| 2013 |
Maier W, Bednorz M, Meister S, Roebroek A, Weggen S, Schmitt U, Pietrzik CU. LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. Molecular Neurodegeneration. 8: 25. PMID 23866919 DOI: 10.1186/1750-1326-8-25 |
0.604 |
|
| 2013 |
Wagner T, Dieckmann M, Jaeger S, Weggen S, Pietrzik CU. Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing. Experimental Cell Research. 319: 1956-72. PMID 23701949 DOI: 10.1016/J.Yexcr.2013.05.010 |
0.603 |
|
| 2013 |
Gil SY, Youn BS, Byun K, Huang H, Namkoong C, Jang PG, Lee JY, Jo YH, Kang GM, Kim HK, Shin MS, Pietrzik CU, Lee B, Kim YB, Kim MS. Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nature Communications. 4: 1862. PMID 23673647 DOI: 10.1038/Ncomms2896 |
0.326 |
|
| 2013 |
Jefferson T, Auf Dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, ... Pietrzik CU, et al. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10 Cellular and Molecular Life Sciences. 70: 309-333. PMID 22940918 DOI: 10.1007/S00018-012-1106-2 |
0.353 |
|
| 2012 |
Rennhack A, Jumpertz T, Ness J, Baches S, Pietrzik CU, Weggen S, Bulic B. Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells. Bioorganic & Medicinal Chemistry. 20: 6523-32. PMID 23000293 DOI: 10.1016/J.Bmc.2012.08.034 |
0.708 |
|
| 2012 |
Bien J, Jefferson T, Causević M, Jumpertz T, Munter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU. The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species. The Journal of Biological Chemistry. 287: 33304-13. PMID 22879596 DOI: 10.1074/Jbc.M112.395608 |
0.725 |
|
| 2012 |
Zettl H, Ness J, Hähnke V, Beher D, Jumpertz T, Saric A, Baumann K, Pietrzik CU, Bulic B, Schneider G, Weggen S. Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening. Acs Chemical Biology. 7: 1488-95. PMID 22725102 DOI: 10.1021/Cb3001952 |
0.648 |
|
| 2012 |
Wagner S, Zensi A, Wien SL, Tschickardt SE, Maier W, Vogel T, Worek F, Pietrzik CU, Kreuter J, von Briesen H. Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model. Plos One. 7: e32568. PMID 22396775 DOI: 10.1371/Journal.Pone.0032568 |
0.304 |
|
| 2012 |
Müller UC, Pietrzik CU, Deller T. The physiological functions of the β-amyloid precursor protein APP. Experimental Brain Research. 217: 325-9. PMID 22349563 DOI: 10.1007/S00221-012-3039-2 |
0.466 |
|
| 2012 |
Pflanzner T, Petsch B, André-Dohmen B, Müller-Schiffmann A, Tschickardt S, Weggen S, Stitz L, Korth C, Pietrzik CU. Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 628-32. PMID 22293988 DOI: 10.1038/Jcbfm.2012.7 |
0.663 |
|
| 2012 |
Jumpertz T, Rennhack A, Ness J, Baches S, Pietrzik CU, Bulic B, Weggen S. Presenilin is the molecular target of acidic γ-secretase modulators in living cells. Plos One. 7: e30484. PMID 22238696 DOI: 10.1371/Journal.Pone.0030484 |
0.679 |
|
| 2012 |
Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU. APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cellular and Molecular Life Sciences : Cmls. 69: 1353-75. PMID 22105709 DOI: 10.1007/S00018-011-0882-4 |
0.796 |
|
| 2012 |
Wagner T, Pietrzik CU. The role of lipoprotein receptors on the physiological function of APP. Experimental Brain Research. 217: 377-87. PMID 21947084 DOI: 10.1007/S00221-011-2876-8 |
0.371 |
|
| 2012 |
Bien J, Jefferson T, Causevic M, Jumpertz T, Munter LM, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik C. O2-04-04: The metalloprotease meprin beta generates amino-terminally truncated beta-amyloid peptide species Alzheimer's & Dementia. 8: P242-P242. DOI: 10.1016/J.Jalz.2012.05.643 |
0.641 |
|
| 2011 |
Jefferson T, Čaušević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. The Journal of Biological Chemistry. 286: 27741-50. PMID 21646356 DOI: 10.1074/Jbc.M111.252718 |
0.707 |
|
| 2011 |
Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik CU. Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Current Alzheimer Research. 8: 115-31. PMID 21345168 DOI: 10.2174/156720511795256099 |
0.774 |
|
| 2011 |
Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 699-712. PMID 21210284 DOI: 10.1007/S00702-010-0572-7 |
0.414 |
|
| 2011 |
Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. Journal of Neurochemistry. 116: 385-95. PMID 21091478 DOI: 10.1111/J.1471-4159.2010.07118.X |
0.671 |
|
| 2011 |
Pflanzner T, Janko MC, André-Dohmen B, Reuss S, Weggen S, Roebroek AJ, Kuhlmann CR, Pietrzik CU. LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier. Neurobiology of Aging. 32: 2323.e1-11. PMID 20630619 DOI: 10.1016/J.Neurobiolaging.2010.05.025 |
0.678 |
|
| 2010 |
Pflanzner T, Kuhlmann CR, Pietrzik CU. Blood-brain-barrier models for the investigation of transporter- and receptor-mediated amyloid-β clearance in Alzheimer's disease Current Alzheimer Research. 7: 578-590. PMID 20704558 DOI: 10.2174/156720510793499066 |
0.455 |
|
| 2010 |
Reekmans SM, Pflanzner T, Gordts PL, Isbert S, Zimmermann P, Annaert W, Weggen S, Roebroek AJ, Pietrzik CU. Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis. Cellular and Molecular Life Sciences : Cmls. 67: 135-45. PMID 19856143 DOI: 10.1007/S00018-009-0171-7 |
0.615 |
|
| 2009 |
Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. Journal of Neurochemistry. 111: 1369-82. PMID 19804379 DOI: 10.1111/J.1471-4159.2009.06420.X |
0.762 |
|
| 2009 |
Kuhlmann CR, Librizzi L, Closhen D, Pflanzner T, Lessmann V, Pietrzik CU, de Curtis M, Luhmann HJ. Mechanisms of C-reactive protein-induced blood-brain barrier disruption. Stroke; a Journal of Cerebral Circulation. 40: 1458-66. PMID 19246692 DOI: 10.1161/Strokeaha.108.535930 |
0.331 |
|
| 2009 |
Leuchtenberger S, Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S. Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein. Neuro-Degenerative Diseases. 6: 1-8. PMID 18349521 DOI: 10.1159/000121391 |
0.669 |
|
| 2009 |
Lehmann S, Bruening T, Ness J, Czirr E, Bulic B, Pietrzik CU, Weggen S. P3-271: Presenilin-1 (PS1) and amyloid precursor protein (APP) mutations present in mouse models of Alzheimer's disease in their response to γ-secretase inhibitors and modulators Alzheimer's & Dementia. 5: P422-P423. DOI: 10.1016/J.Jalz.2009.04.942 |
0.697 |
|
| 2009 |
Ness JS, Riemenschneider MJ, Baches S, Eriksen JL, Pietrzik CU, Reifenberger G, Weggen S. P4-244: Progranulin (GRN), a protein mutated in frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U), is abundantly expressed in human gliomas Alzheimer's & Dementia. 5: P502-P502. DOI: 10.1016/J.Jalz.2009.04.710 |
0.612 |
|
| 2008 |
Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12097-106. PMID 19005074 DOI: 10.1523/Jneurosci.2635-08.2008 |
0.404 |
|
| 2008 |
Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU, Ghebremedhin E, Thal DR. Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. Journal of Neuropathology and Experimental Neurology. 67: 842-56. PMID 18716559 DOI: 10.1097/Nen.0B013E3181836A71 |
0.46 |
|
| 2008 |
Waldron E, Heilig C, Schweitzer A, Nadella N, Jaeger S, Martin AM, Weggen S, Brix K, Pietrzik CU. LRP1 modulates APP trafficking along early compartments of the secretory pathway. Neurobiology of Disease. 31: 188-97. PMID 18559293 DOI: 10.1016/J.Nbd.2008.04.006 |
0.715 |
|
| 2008 |
Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C, Weggen S, De Strooper B, Pietrzik CU. Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. Experimental Cell Research. 314: 2419-33. PMID 18559276 DOI: 10.1016/J.Yexcr.2008.05.003 |
0.665 |
|
| 2008 |
Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. The Journal of Biological Chemistry. 283: 17049-54. PMID 18426795 DOI: 10.1074/Jbc.M802912200 |
0.766 |
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| 2008 |
Martin AM, Kuhlmann C, Trossbach S, Jaeger S, Waldron E, Roebroek A, Luhmann HJ, Laatsch A, Weggen S, Lessmann V, Pietrzik CU. The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 283: 12004-13. PMID 18321860 DOI: 10.1074/Jbc.M707607200 |
0.62 |
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| 2008 |
Jaeger S, Pietrzik CU. Functional role of lipoprotein receptors in Alzheimer's disease. Current Alzheimer Research. 5: 15-25. PMID 18288927 DOI: 10.2174/156720508783884675 |
0.542 |
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| 2008 |
Thal DR, Tamboli IY, Walter J, Birkenmeier G, Pietrzik CU, Utter S. P4-295: Small vessel disease–induced microvascular protein leakage provides a possible pathogenetic link to Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2364 |
0.363 |
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| 2008 |
Czirr E, Cottrell BA, Serneels L, Leuchtenberger S, Schubenel R, Torpey JW, Esselmann H, Pietrzik CU, Wiltfang J, DeStrooper B, Baumann K, Koo EH, Weggen S. P4-192: Mechanism of γ-secretase cleavage: Evidence for independent generation of Aβ42 and Aβ38 peptide species Alzheimer's & Dementia. 4: T727-T728. DOI: 10.1016/J.Jalz.2008.05.2259 |
0.733 |
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| 2008 |
Pietrzik CU, Jaeger S, Wesselowski J, Cirr E, Korth C, Weggen S, Koo EH, Pietrzik KF. P3-344: γ-secretase-dependent APP processing occurs either at the plasma membrane or in the endocytic compartments independent of the APP wild-type or APP Swedish variant Alzheimer's & Dementia. 4: T622-T622. DOI: 10.1016/J.Jalz.2008.05.1913 |
0.715 |
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| 2007 |
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Müller UC. The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7817-26. PMID 17634375 DOI: 10.1523/Jneurosci.1026-07.2007 |
0.524 |
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| 2007 |
Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. The Journal of Biological Chemistry. 282: 24504-13. PMID 17573346 DOI: 10.1074/Jbc.M700618200 |
0.754 |
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| 2006 |
Waldron E, Jaeger S, Pietrzik CU. Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease. Neuro-Degenerative Diseases. 3: 233-8. PMID 17047362 DOI: 10.1159/000095261 |
0.537 |
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| 2006 |
Neumann S, Schöbel S, Jäger S, Trautwein A, Haass C, Pietrzik CU, Lichtenthaler SF. Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein. The Journal of Biological Chemistry. 281: 7583-94. PMID 16344553 DOI: 10.1074/Jbc.M508340200 |
0.552 |
|
| 2006 |
Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. Journal of Neurochemistry. 96: 355-65. PMID 16300630 DOI: 10.1111/J.1471-4159.2005.03553.X |
0.815 |
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| 2006 |
Czirr E, Leuchtenberger S, Schneider A, Koo EH, Pietrzik CU, Weggen S. O1-02-06: Genetic dissection of the PS1-ΔExon9 mutation and its attenuated response to Aβ42-lowering NSAIDs Alzheimer's & Dementia. 2: S11-S12. DOI: 10.1016/J.Jalz.2006.05.258 |
0.539 |
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| 2006 |
Neumann S, Schöbel S, Jäger S, Haass C, Pietrzik CU, Lichtenthaler SF. P4-070: Amyloid precursor-like proteins 1 and 2 influence proteolytic processing of the amyloid precursor protein by alpha- and beta-secretase Alzheimer's & Dementia. 2: S534-S534. DOI: 10.1016/J.Jalz.2006.05.1808 |
0.436 |
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| 2006 |
Jaeger S, Rogge BS, Weggen S, Koo EH, Pietrzik CU. P3-247: Functional consequences of LRP expression on familiar Alzheimer disease APP mutations Alzheimer's & Dementia. 2: S448-S448. DOI: 10.1016/J.Jalz.2006.05.1516 |
0.592 |
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| 2005 |
Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. The Journal of Biological Chemistry. 280: 27303-9. PMID 15917251 DOI: 10.1074/Jbc.M413969200 |
0.665 |
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| 2005 |
Pietrzik C, Behl C. Concepts for the treatment of Alzheimer's disease: molecular mechanisms and clinical application. International Journal of Experimental Pathology. 86: 173-85. PMID 15910551 DOI: 10.1111/J.0959-9673.2005.00435.X |
0.358 |
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| 2005 |
Goodenough S, Schleusner D, Pietrzik C, Skutella T, Behl C. Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes. Neuroscience. 132: 581-9. PMID 15837120 DOI: 10.1016/J.Neuroscience.2004.12.029 |
0.37 |
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| 2005 |
Yoon IS, Pietrzik CU, Kang DE, Koo EH. Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. The Journal of Biological Chemistry. 280: 20140-7. PMID 15772078 DOI: 10.1074/Jbc.M413729200 |
0.781 |
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| 2004 |
Pietrzik CU, Yoon IS, Jaeger S, Busse T, Weggen S, Koo EH. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4259-65. PMID 15115822 DOI: 10.1523/Jneurosci.5451-03.2004 |
0.73 |
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| 2004 |
Pietrzik CU, Jaeger S, Yoon I, Busse T, Weggen S, Koo EH. P3-296 FE65 constitutes the functional link between the LDL receptor-related protein (LRP) and APP Neurobiology of Aging. 25: S439. DOI: 10.1016/S0197-4580(04)81446-5 |
0.7 |
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| 2003 |
Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. The Journal of Biological Chemistry. 278: 31831-7. PMID 12805356 DOI: 10.1074/Jbc.M303592200 |
0.738 |
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| 2003 |
Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. The Journal of Biological Chemistry. 278: 30748-54. PMID 12777371 DOI: 10.1074/Jbc.M304824200 |
0.77 |
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| 2002 |
Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/Nbdi.2002.0546 |
0.645 |
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| 2002 |
Pietrzik CU, Busse T, Merriam DE, Weggen S, Koo EH. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. The Embo Journal. 21: 5691-700. PMID 12411487 DOI: 10.1093/Emboj/Cdf568 |
0.777 |
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| 2001 |
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414: 212-6. PMID 11700559 DOI: 10.1038/35102591 |
0.821 |
|
| 2001 |
Soriano S, Lu DC, Chandra S, Pietrzik CU, Koo EH. The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases. The Journal of Biological Chemistry. 276: 29045-50. PMID 11397796 DOI: 10.1074/Jbc.M102456200 |
0.796 |
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| 2000 |
Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. The Journal of Clinical Investigation. 106: 1159-66. PMID 11067868 DOI: 10.1172/Jci11013 |
0.78 |
|
| 1999 |
Hoffmann J, Pietrzik CU, Kummer MP, Twiesselmann C, Bauer C, Herzog V. Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 47: 373-82. PMID 10026239 DOI: 10.1177/002215549904700311 |
0.72 |
|
| 1998 |
Pietrzik CU, Hoffmann J, Stöber K, Chen CY, Bauer C, Otero DA, Roch JM, Herzog V. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 1770-5. PMID 9465092 DOI: 10.1073/Pnas.95.4.1770 |
0.566 |
|
| 1997 |
Overdick M, Czermak A, Fischer P, Herzog V, Kjensmo A, Kugelmeier T, Ljunggren K, Nygård E, Pietrzik C, Schwan T, Strand S, Straver J, Weilhammer P, Wermes N, Yoshioka K. A “Bioscope” system using double-sided silicon strip detectors and self-triggering read-out chips Nuclear Instruments and Methods in Physics Research Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 392: 173-177. DOI: 10.1016/S0168-9002(97)00251-9 |
0.433 |
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| 1996 |
Popp GM, Graebert KS, Pietrzik CU, Rosentreter SM, Lemansky P, Herzog V. Growth regulation of rat thyrocytes (FRTL-5 cells) by the secreted ectodomain of beta-amyloid precursor-like proteins. Endocrinology. 137: 1975-83. PMID 8612538 DOI: 10.1210/Endo.137.5.8612538 |
0.572 |
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