Emmanuel Darcq - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Rahman MT, Decker AM, Laudermilk L, Maitra R, Ma W, Ben Hamida S, Darcq E, Kieffer BL, Jin C. Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies. Journal of Medicinal Chemistry. PMID 34387471 DOI: 10.1021/acs.jmedchem.1c01075  1
2021 Ehrlich AT, Darcq E. Recent advances in basic science methodology to evaluate opioid safety profiles and to understand opioid activities. Faculty Reviews. 10: 15. PMID 33718932 DOI: 10.12703/r/10-15  1
2021 Nasseef MT, Ma W, Singh JP, Dozono N, Lançon K, Séguéla P, Darcq E, Ueda H, Kieffer BL. Chronic generalized pain disrupts whole brain functional connectivity in mice. Brain Imaging and Behavior. PMID 33428113 DOI: 10.1007/s11682-020-00438-9  1
2020 Rahman MT, Decker AM, Langston TL, Mathews KM, Laudermilk L, Maitra R, Ma W, Darcq E, Kieffer BL, Jin C. Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists. Journal of Medicinal Chemistry. PMID 33205975 DOI: 10.1021/acs.jmedchem.0c01581  1
2020 Bailly J, Del Rossi N, Runtz L, Li JJ, Park D, Scherrer G, Tanti A, Birling MC, Darcq E, Kieffer BL. Targeting morphine-responsive neurons: generation of a knock-in mouse line expressing Cre recombinase from the mu opioid receptor gene locus. Eneuro. PMID 32381649 DOI: 10.1523/ENEURO.0433-19.2020  1
2020 Neasta J, Darcq E, Jeanblanc J, Carnicella S, Ben Hamida S. GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31919661 DOI: 10.1007/S13311-019-00828-Y  1
2019 Nasseef MT, Singh JP, Ehrlich AT, McNicholas M, Park DW, Ma W, Kulkarni P, Kieffer BL, Darcq E. Oxycodone-Mediated Activation of the Mu Opioid Receptor Reduces Whole Brain Functional Connectivity in Mice. Acs Pharmacology & Translational Science. 2: 264-274. PMID 32259060 DOI: 10.1021/acsptsci.9b00021  1
2019 Welsch L, Bailly J, Darcq E, Kieffer BL. The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models. Biological Psychiatry. PMID 31521334 DOI: 10.1016/J.Biopsych.2019.07.027  1
2019 Boulos LJ, Ben Hamida S, Bailly J, Maitra M, Ehrlich AT, Gavériaux-Ruff C, Darcq E, Kieffer BL. Mu opioid receptors in the medial habenula contribute to naloxone aversion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31005059 DOI: 10.1038/S41386-019-0395-7  1
2019 Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. Iscience. 14: 47-57. PMID 30925410 DOI: 10.1016/J.Isci.2019.03.011  1
2019 Boulos LJ, Nasseef MT, McNicholas M, Mechling A, Harsan LA, Darcq E, Ben Hamida S, Kieffer BL. TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice. Scientific Reports. 9: 4044. PMID 30858487 DOI: 10.1038/S41598-019-40622-6  1
2019 Ehrlich AT, Kieffer BL, Darcq E. Current strategies toward safer mu opioid receptor drugs for pain management. Expert Opinion On Therapeutic Targets. PMID 30802415 DOI: 10.1080/14728222.2019.1586882  1
2019 Ehrlich AT, Darcq E. Recommending buprenorphine for pain management. Pain Management. 9: 13-16. PMID 30507294 DOI: 10.2217/Pmt-2018-0069  1
2018 Nasseef MT, Devenyi GA, Mechling AE, Harsan LA, Chakravarty MM, Kieffer BL, Darcq E. Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice. Frontiers in Psychiatry. 9: 643. PMID 30559685 DOI: 10.3389/Fpsyt.2018.00643  1
2018 Ehrlich AT, Maroteaux G, Robe A, Venteo L, Nasseef MT, van Kempen LC, Mechawar N, Turecki G, Darcq E, Kieffer BL. Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. Communications Biology. 1: 102. PMID 30271982 DOI: 10.1038/s42003-018-0106-7  1
2018 Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R. Discovery of a Potent, Selective, and Brain-Penetrant Small-Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake. Journal of Medicinal Chemistry. PMID 30011199 DOI: 10.1021/Acs.Jmedchem.8B00566  1
2018 Darcq E, Kieffer BL. Opioid receptors: drivers to addiction? Nature Reviews. Neuroscience. PMID 29934561 DOI: 10.1038/S41583-018-0028-X  1
2018 Darcq E, Kieffer BL. The Control of Reward Seeking. Biological Psychiatry. 83: 981-983. PMID 29804588 DOI: 10.1016/J.Biopsych.2018.04.003  1
2018 Ben Hamida S, Mendonça-Netto S, Arefin TM, Nasseef MT, Boulos LJ, McNicholas M, Ehrlich AT, Clarke E, Moquin L, Gratton A, Darcq E, Harsan LA, Maldonado R, Kieffer BL. Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks. Biological Psychiatry. PMID 29580570 DOI: 10.1016/J.Biopsych.2018.01.026  1
2018 Maroteaux G, Arefin TM, Harsan LA, Darcq E, Ben Hamida S, Kieffer BL. Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping. Genes, Brain, and Behavior. e12473. PMID 29575471 DOI: 10.1111/Gbb.12473  1
2017 Cruceanu C, Schmouth JF, Torres-Platas SG, Lopez JP, Ambalavanan A, Darcq E, Gross F, Breton B, Spiegelman D, Rochefort D, Hince P, Petite JM, Gauthier J, Lafrenière RG, Dion PA, et al. Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors. Molecular Psychiatry. PMID 29158579 DOI: 10.1038/mp.2017.223  1
2017 Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL. Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing. Brain Structure & Function. PMID 29110094 DOI: 10.1007/S00429-017-1547-3  1
2017 Phamluong K, Darcq E, Wu S, Sakhai SA, Ron D. Fyn Signaling Is Compartmentalized to Dopamine D1 Receptor Expressing Neurons in the Dorsal Medial Striatum. Frontiers in Molecular Neuroscience. 10: 273. PMID 28912680 DOI: 10.3389/Fnmol.2017.00273  1
2017 Boulos LJ, Darcq E, Kieffer BL. Translating the Habenula-From Rodents to Humans. Biological Psychiatry. 81: 296-305. PMID 27527822 DOI: 10.1016/J.Biopsych.2016.06.003  1
2016 Charbogne P, Gardon O, Martín-García E, Keyworth HL, Matsui A, Mechling AE, Bienert T, Nasseef T, Robé A, Moquin L, Darcq E, Ben Hamida S, Robledo P, Matifas A, Befort K, et al. Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food. Biological Psychiatry. PMID 28185645 DOI: 10.1016/J.Biopsych.2016.12.022  1
2016 Moore K, Madularu D, Iriah S, Yee JR, Kulkarni P, Darcq E, Kieffer BL, Ferris CF. BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone. Frontiers in Neuroscience. 10: 471. PMID 27857679 DOI: 10.3389/Fnins.2016.00471  1
2016 Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10116-27. PMID 27683907 DOI: 10.1523/Jneurosci.4597-14.2016  1
2016 Mechling AE, Arefin T, Lee HL, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ, Rosa-Neto P, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome. Proceedings of the National Academy of Sciences of the United States of America. PMID 27671662 DOI: 10.1073/Pnas.1601640113  1
2015 Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice that Is Reversed by Tropomyosin Receptor Kinase B Activation. Biological Psychiatry. PMID 26204799 DOI: 10.1016/J.Biopsych.2015.06.007  1
2015 Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. Plos One. 10: e0127408. PMID 25992601 DOI: 10.1371/Journal.Pone.0127408  1
2015 Darcq E, Kieffer BL. PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research. Embo Molecular Medicine. 7: 859-61. PMID 25925427 DOI: 10.15252/Emmm.201505266  1
2015 Chung PC, Boehrer A, Stephan A, Matifas A, Scherrer G, Darcq E, Befort K, Kieffer BL. Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures. Behavioural Brain Research. 278: 429-34. PMID 25447299 DOI: 10.1016/J.Bbr.2014.10.029  1
2015 Chu Sin Chung P, Keyworth HL, Martin-Garcia E, Charbogne P, Darcq E, Bailey A, Filliol D, Matifas A, Scherrer G, Ouagazzal AM, Gaveriaux-Ruff C, Befort K, Maldonado R, Kitchen I, Kieffer BL. A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons. Biological Psychiatry. 77: 404-15. PMID 25444168 DOI: 10.1016/J.Biopsych.2014.07.033  1
2015 Darcq E, Kieffer BL. PI3K signaling in the locus coeruleus: A new molecular pathway for ADHD research Embo Molecular Medicine. 7: 859-861. DOI: 10.15252/emmm.201505266  1
2014 Darcq E, Warnault V, Phamluong K, Besserer GM, Liu F, Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Molecular Psychiatry. PMID 25385365 DOI: 10.1038/Mp.2014.155  1
2014 Darcq E, Warnault V, Phamluong K, Besserer GM, Liu F, Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Molecular Psychiatry. PMID 25330738 DOI: 10.1038/mp.2014.120  1
2014 Darcq E, Hamida SB, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption. Journal of Neurochemistry. 129: 1024-34. PMID 24588427 DOI: 10.1111/Jnc.12701  1
2013 Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, Ron D. Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14369-78. PMID 24005290 DOI: 10.1523/Jneurosci.1954-13.2013  1
2013 Warnault V, Darcq E, Levine A, Barak S, Ron D. Chromatin remodeling--a novel strategy to control excessive alcohol drinking. Translational Psychiatry. 3: e231. PMID 23423140 DOI: 10.1038/Tp.2013.4  1
2012 Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, Ron D. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15124-32. PMID 23100433 DOI: 10.1523/Jneurosci.2783-12.2012  1
2012 Darcq E, Befort K, Koebel P, Pannetier S, Mahoney MK, Gaveriaux-Ruff C, Hanauer A, Kieffer BL. RSK2 signaling in medial habenula contributes to acute morphine analgesia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1288-96. PMID 22218090 DOI: 10.1038/Npp.2011.316  1
2012 Le Merrer J, Befort K, Gardon O, Filliol D, Darcq E, Dembele D, Becker JA, Kieffer BL. Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network. Addiction Biology. 17: 1-12. PMID 21955143 DOI: 10.1111/J.1369-1600.2011.00365.X  1
2011 Darcq E, Koebel P, Del Boca C, Pannetier S, Kirstetter AS, Garnier JM, Hanauer A, Befort K, Kieffer BL. RSK2 signaling in brain habenula contributes to place aversion learning. Learning & Memory (Cold Spring Harbor, N.Y.). 18: 574-8. PMID 21852432 DOI: 10.1101/Lm.2221011  1
2011 Goeldner C, Lutz PE, Darcq E, Halter T, Clesse D, Ouagazzal AM, Kieffer BL. Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine. Biological Psychiatry. 69: 236-44. PMID 20947067 DOI: 10.1016/J.Biopsych.2010.08.021  1
2008 Befort K, Filliol D, Darcq E, Ghate A, Matifas A, Lardenois A, Muller J, Thibault C, Dembele D, Poch O, Kieffer BL. Gene expression is altered in the lateral hypothalamus upon activation of the mu opioid receptor. Annals of the New York Academy of Sciences. 1129: 175-84. PMID 18591478 DOI: 10.1196/Annals.1417.028  1
2008 Befort K, Filliol D, Ghate A, Darcq E, Matifas A, Muller J, Lardenois A, Thibault C, Dembele D, Le Merrer J, Becker JA, Poch O, Kieffer BL. Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala. The European Journal of Neuroscience. 27: 2973-84. PMID 18588537 DOI: 10.1111/J.1460-9568.2008.06273.X  1
1975 Colas JM, Paoletti G, Darcq E, Bittard M. [Renal arteriovenous fistual of neoplastic origin]. Journal D'Urologie Et De Nephrologie. 81: 423-8. PMID 1152136  0.01
1975 Colas JM, Dupond JL, Saint-Hillier Y, Darcq E, Bittard M. [Urinary lithiasis and parathyroid adenoma]. Journal D'Urologie Et De Nephrologie. 81: 419-23. PMID 1152135  0.01
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