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Yuanyuan Chen - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
retinal degeneration, rhodopsin folding and signaling
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Liu X, Feng B, Vats A, Tang H, Seibel W, Swaroop M, Tawa G, Zheng W, Byrne L, Schurdak M, Chen Y. Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32536017 DOI: 10.1096/Fj.202000282R  0.306
2019 Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900443RR. PMID 31121099 DOI: 10.1096/Fj.201900443Rr  0.498
2019 Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. The Journal of Biological Chemistry. PMID 31073029 DOI: 10.1074/Jbc.Ra119.008697  0.46
2019 Feng B, Liu X, Chen Y. A Rhodopsin Transport Assay by High-Content Imaging Analysis. Journal of Visualized Experiments : Jove. PMID 30735172 DOI: 10.3791/58703  0.304
2018 Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, et al. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nature Communications. 9: 1976. PMID 29773803 DOI: 10.1038/S41467-018-04261-1  0.472
2016 Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome Profiling of NIH3T3 Cell Lines Expressing Opsin and the P23H Opsin Mutant Identifies Candidate Drugs for the Treatment of Retinitis Pigmentosa. Pharmacological Research. PMID 27838510 DOI: 10.1016/J.Phrs.2016.10.031  0.481
2015 Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. The Journal of Biological Chemistry. 290: 25728-44. PMID 26330551 DOI: 10.1074/Jbc.M115.662684  0.46
2015 Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K. A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Investigative Ophthalmology & Visual Science. 56: 2553-67. PMID 25783607 DOI: 10.1167/Iovs.14-16298  0.479
2015 Chen Y, Tang H. High-throughput screening assays to identify small molecules preventing photoreceptor degeneration caused by the rhodopsin P23H mutation. Methods in Molecular Biology (Clifton, N.J.). 1271: 369-90. PMID 25697536 DOI: 10.1007/978-1-4939-2330-4_24  0.3
2014 Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Molecular Pharmacology. 86: 231-42. PMID 24913940 DOI: 10.1124/Mol.114.093070  0.633
2014 Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K. Inherent instability of the retinitis pigmentosa P23H mutant opsin. The Journal of Biological Chemistry. 289: 9288-303. PMID 24515108 DOI: 10.1074/Jbc.M114.551713  0.457
2012 Liberman JA, Guo M, Jenkins JL, Krucinska J, Chen Y, Carey PR, Wedekind JE. A transition-state interaction shifts nucleobase ionization toward neutrality to facilitate small ribozyme catalysis. Journal of the American Chemical Society. 134: 16933-6. PMID 22989273 DOI: 10.1021/Ja3070528  0.523
2012 Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. The Journal of Biological Chemistry. 287: 13356-70. PMID 22356908 DOI: 10.1074/Jbc.M112.347518  0.635
2011 Chen Y, Basu R, Gleghorn ML, Murakami KS, Carey PR. Time-resolved events on the reaction pathway of transcript initiation by a single-subunit RNA polymerase: Raman crystallographic evidence. Journal of the American Chemical Society. 133: 12544-55. PMID 21744806 DOI: 10.1021/Ja201557W  0.535
2011 Carey PR, Chen Y, Gong B, Kalp M. Kinetic crystallography by Raman microscopy. Biochimica Et Biophysica Acta. 1814: 742-9. PMID 20797452 DOI: 10.1016/J.Bbapap.2010.08.006  0.553
2010 Chen Y, Eldho NV, Dayie TK, Carey PR. Probing adenine rings and backbone linkages using base specific isotope-edited Raman spectroscopy: application to group II intron ribozyme domain V. Biochemistry. 49: 3427-35. PMID 20225830 DOI: 10.1021/Bi902117W  0.509
2009 Gong B, Chen JH, Yajima R, Chen Y, Chase E, Chadalavada DM, Golden BL, Carey PR, Bevilacqua PC. Raman crystallography of RNA. Methods (San Diego, Calif.). 49: 101-11. PMID 19409996 DOI: 10.1016/J.Ymeth.2009.04.016  0.515
2008 Gong B, Chen Y, Christian EL, Chen JH, Chase E, Chadalavada DM, Yajima R, Golden BL, Bevilacqua PC, Carey PR. Detection of innersphere interactions between magnesium hydrate and the phosphate backbone of the HDV ribozyme using Raman crystallography. Journal of the American Chemical Society. 130: 9670-2. PMID 18593125 DOI: 10.1021/Ja801861S  0.517
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