Luis Miguel GARCIA-SEGURA, PhD - Publications

Affiliations: 
CSIC Cajal Institute, Madrid, Spain 

206 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hidalgo-Lanussa O, Baez-Jurado E, Echeverria V, Ashraf GM, Sahebkar A, Garcia-Segura LM, Melcangi RC, Barreto GE. Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds. Journal of Neuroendocrinology. e12776. PMID 31334878 DOI: 10.1111/jne.12776  0.48
2019 Acaz-Fonseca E, Ortiz-Rodriguez A, Garcia-Segura LM, Astiz M. Sex differences and gonadal hormone regulation of brain cardiolipin, a key mitochondrial phospholipid. Journal of Neuroendocrinology. e12774. PMID 31323169 DOI: 10.1111/jne.12774  0.4
2019 Marraudino M, Farinetti A, Arevalo MA, Gotti S, Panzica G, Garcia-Segura LM. Sexually Dimorphic Effect of Genistein on Hypothalamic Neuronal Differentiation in Vitro. International Journal of Molecular Sciences. 20. PMID 31109056 DOI: 10.3390/ijms20102465  0.64
2019 Giatti S, Diviccaro S, Garcia-Segura LM, Melcangi RC. Sex differences in the brain expression of steroidogenic molecules under basal conditions and after gonadectomy. Journal of Neuroendocrinology. e12736. PMID 31102564 DOI: 10.1111/jne.12736  0.48
2018 Diviccaro S, Giatti S, Borgo F, Barcella M, Borghi E, Trejo JL, Garcia-Segura LM, Melcangi RC. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition. Psychoneuroendocrinology. 99: 206-215. PMID 30265917 DOI: 10.1016/j.psyneuen.2018.09.021  0.48
2018 Pesaresi M, Giatti S, Spezzano R, Romano S, Diviccaro S, Borsello T, Mitro N, Caruso D, Garcia-Segura LM, Melcangi RC. Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features. Biology of Sex Differences. 9: 6. PMID 29351809 DOI: 10.1186/s13293-018-0164-z  0.48
2017 Romano S, Mitro N, Giatti S, Diviccaro S, Pesaresi M, Spezzano R, Audano M, Garcia-Segura LM, Caruso D, Melcangi RC. Diabetes induces mitochondrial dysfunction and alters cholesterol homeostasis and neurosteroidogenesis in the rat cerebral cortex. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29183767 DOI: 10.1016/j.jsbmb.2017.11.009  0.48
2017 Cisternas CD, Cabrera Zapata LE, Arevalo MA, Garcia-Segura LM, Cambiasso MJ. Regulation of aromatase expression in the anterior amygdala of the developing mouse brain depends on ERβ and sex chromosome complement. Scientific Reports. 7: 5320. PMID 28706210 DOI: 10.1038/s41598-017-05658-6  0.64
2016 Romano S, Mitro N, Diviccaro S, Spezzano R, Audano M, Garcia-Segura LM, Caruso D, Melcangi RC. SHORT-TERM EFFECTS OF DIABETES ON NEUROSTEROIDOGENESIS IN THE RAT HIPPOCAMPUS. The Journal of Steroid Biochemistry and Molecular Biology. PMID 27890531 DOI: 10.1016/j.jsbmb.2016.11.019  0.48
2016 Pietranera L, Correa J, Brocca ME, Roig P, Lima A, Di Giorgio N, Garcia-Segura LM, De Nicola AF. Selective oestrogen receptor agonists rescued hippocampus parameters in male spontaneously hypertensive rats. Journal of Neuroendocrinology. PMID 27517478 DOI: 10.1111/jne.12415  0.44
2016 Acaz-Fonseca E, Avila-Rodriguez M, Garcia-Segura LM, Barreto GE. Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions. Progress in Neurobiology. PMID 27283249 DOI: 10.1016/j.pneurobio.2016.06.002  0.4
2016 Avila-Rodriguez M, Garcia-Segura LM, Hidalgo-Lanussa O, Baez E, Gonzalez J, Barreto GE. Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression. Molecular and Cellular Endocrinology. PMID 27250720 DOI: 10.1016/j.mce.2016.05.024  1
2016 Vieira-Marques C, Arbo BD, Ruiz-Palmero I, Ortiz-Rodriguez A, Ghorbanpoor S, Kucharski LC, Arevalo MA, Garcia-Segura LM, Ribeiro MF. DEHYDROEPIANDROSTERONE PROTECTS MALE AND FEMALE HIPPOCAMPAL NEURONS AND NEUROBLASTOMA CELLS FROM GLUCOSE DEPRIVATION. Brain Research. PMID 27174000 DOI: 10.1016/j.brainres.2016.05.014  0.64
2016 Lopez-Rodriguez AB, Mela V, Acaz-Fonseca E, Garcia-Segura LM, Viveros MP. CB2 cannabinoid receptor is involved in the anti-inflammatory effects of leptin in a model of traumatic brain injury. Experimental Neurology. PMID 27006282 DOI: 10.1016/j.expneurol.2016.03.018  1
2016 Grassi D, Lagunas N, Pinos H, Panzica G, Garcia-Segura LM, Collado P. NADPH-Diaphorase Colocalizes with GPER and is Modulated by the GPER agonist G1 in the SON and PVN of Ovariectomized Female Rats. Neuroendocrinology. PMID 26954778 DOI: 10.1159/000445190  0.36
2016 Astiz M, Pernía O, Barrios V, Garcia-Segura LM, Diz-Chaves Y. Short-Term High Fat Diet-Feeding Provides Hypothalamic But Not Hippocampal Protection Against Acute Infection in Male Mice. Neuroendocrinology. PMID 26862917 DOI: 10.1159/000444527  1
2016 Arbo BD, Marques CV, Ruiz-Palmero I, Ortiz-Rodriguez A, Ghorbanpoor S, Arevalo MA, Garcia-Segura LM, Ribeiro MF. 4′-Chlorodiazepam is neuroprotective against amyloid-beta through the modulation of survivin and bax protein expression in vitro Brain Research. 1632: 91-97. DOI: 10.1016/j.brainres.2015.12.018  1
2015 Mitro N, Cermenati G, Audano M, Giatti S, D'Antonio M, Fabiani ED, Crestani M, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D. The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function. Springerplus. 4: L45. PMID 27386207 DOI: 10.1186/2193-1801-4-S1-L45  1
2015 Melcangi RC, Giatti S, Garcia-Segura LM. Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features. Neuroscience and Biobehavioral Reviews. PMID 26657814 DOI: 10.1016/j.neubiorev.2015.09.023  1
2015 Giatti S, Foglio B, Romano S, Pesaresi M, Panzica G, Garcia-Segura LM, Caruso D, Melcangi RC. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and their Receptors in the Male Rat Brain. Neuroendocrinology. PMID 26646518 DOI: 10.1159/000442982  1
2015 Traish AM, Melcangi RC, Bortolato M, Garcia-Segura LM, Zitzmann M. Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know? Reviews in Endocrine & Metabolic Disorders. PMID 26296373 DOI: 10.1007/s11154-015-9319-y  0.48
2015 Grassi D, Ghorbanpoor S, Acaz-Fonseca E, Ruiz-Palmero I, Garcia-Segura LM. The Selective Estrogen Receptor Modulator Raloxifene Regulates Arginine-Vasopressin Gene Expression in Human Female Neuroblastoma Cells Through G Protein-Coupled Estrogen Receptor and ERK Signaling. Endocrinology. 156: 3706-16. PMID 26200092 DOI: 10.1210/en.2014-2010  1
2015 Lopez-Rodriguez AB, Acaz-Fonseca E, Viveros MP, Garcia-Segura LM. Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficit. Plos One. 10: e0128782. PMID 26039099 DOI: 10.1371/journal.pone.0128782  0.4
2015 Acaz-Fonseca E, Duran JC, Carrero P, Garcia-Segura LM, Arevalo MA. Sex differences in glia reactivity after cortical brain injury. Glia. PMID 26037411 DOI: 10.1002/glia.22867  0.64
2015 Arevalo MA, Azcoitia I, Gonzalez-Burgos I, Garcia-Segura LM. Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol. Hormones and Behavior. PMID 25921586 DOI: 10.1016/j.yhbeh.2015.04.016  1
2015 Giatti S, Romano S, Pesaresi M, Cermenati G, Mitro N, Caruso D, Tetel MJ, Garcia-Segura LM, Melcangi RC. Neuroactive steroids and the peripheral nervous system: An update. Steroids. PMID 25824325 DOI: 10.1016/j.steroids.2015.03.014  1
2015 Zancan M, Dall'Oglio A, Sarzenski TM, Maher MI, Garcia-Segura LM, Rasia-Filho AA. Glial and axonal perikaryal coverage and somatic spines in the posterodorsal medial amygdala of male and cycling female rats. The Journal of Comparative Neurology. PMID 25823984 DOI: 10.1002/cne.23782  1
2015 Cermenati G, Audano M, Giatti S, Carozzi V, Porretta-Serapiglia C, Pettinato E, Ferri C, D'Antonio M, De Fabiani E, Crestani M, Scurati S, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, et al. Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy. Cell Metabolism. 21: 571-83. PMID 25817536 DOI: 10.1016/j.cmet.2015.02.016  1
2015 Giatti S, Garcia-Segura LM, Melcangi RC. New steps forward in the neuroactive steroid field. The Journal of Steroid Biochemistry and Molecular Biology. PMID 25797031 DOI: 10.1016/j.jsbmb.2015.03.002  1
2015 Lopez-Rodriguez AB, Acaz-Fonseca E, Giatti S, Caruso D, Viveros MP, Melcangi RC, Garcia-Segura LM. Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female mice. Psychoneuroendocrinology. 56: 1-11. PMID 25770855 DOI: 10.1016/j.psyneuen.2015.02.018  1
2015 Giatti S, Rigolio R, Romano S, Mitro N, Viviani B, Cavaletti G, Caruso D, Garcia-Segura LM, Melcangi RC. Dihydrotestosterone as a Protective Agent in Chronic Experimental Autoimmune Encephalomyelitis. Neuroendocrinology. 101: 296-308. PMID 25765436 DOI: 10.1159/000381064  1
2015 Arevalo MA, Azcoitia I, Garcia-Segura LM. The neuroprotective actions of oestradiol and oestrogen receptors. Nature Reviews. Neuroscience. 16: 17-29. PMID 25423896 DOI: 10.1038/nrn3856  1
2015 Pietranera L, Brocca ME, Roig P, Lima A, Garcia-Segura LM, De Nicola AF. Estrogens are neuroprotective factors for hypertensive encephalopathy. The Journal of Steroid Biochemistry and Molecular Biology. 146: 15-25. PMID 24736028 DOI: 10.1016/j.jsbmb.2014.04.001  1
2015 Lopez-Rodriguez AB, Siopi E, Finn DP, Marchand-Leroux C, Garcia-Segura LM, Jafarian-Tehrani M, Viveros MP. CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice. Cerebral Cortex (New York, N.Y. : 1991). 25: 35-45. PMID 23960212 DOI: 10.1093/cercor/bht202  1
2015 Lopez-Rodriguez AB, Acaz-Fonseca E, Viveros MP, Garcia-Segura LM. Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficit Plos One. 10. DOI: 10.1371/journal.pone.0128782  1
2015 Mitro N, Cermenati G, Audano M, Giatti S, D’Antonio M, De Fabiani E, Crestani M, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D. The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function Springerplus. 4: 1-32. DOI: 10.1186/2193-1801-4-S1-L45  1
2015 Cisternas CD, Tome K, Caeiro XE, Dadam FM, Garcia-Segura LM, Cambiasso MJ. Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain Molecular and Cellular Endocrinology. 414: 99-110. DOI: 10.1016/j.mce.2015.07.027  1
2015 Arbo BD, Benetti F, Garcia-Segura LM, Ribeiro MF. Therapeutic actions of translocator protein (18 kDa) ligands in experimental models of psychiatric disorders and neurodegenerative diseases Journal of Steroid Biochemistry and Molecular Biology. 154: 68-74. DOI: 10.1016/j.jsbmb.2015.07.007  1
2015 Traish AM, Melcangi RC, Bortolato M, Garcia-Segura LM, Zitzmann M. Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know? Reviews in Endocrine and Metabolic Disorders. DOI: 10.1007/s11154-015-9319-y  1
2015 Acaz-Fonseca E, Duran JC, Carrero P, Garcia-Segura LM, Arevalo MA. Sex differences in glia reactivity after cortical brain injury Glia. DOI: 10.1002/glia.22867  1
2014 Grassi D, Lagunas N, Calmarza-Font I, Diz-Chaves Y, Garcia-Segura LM, Panzica GC. Chronic unpredictable stress and long-term ovariectomy affect arginine-vasopressin expression in the paraventricular nucleus of adult female mice. Brain Research. 1588: 55-62. PMID 25218558 DOI: 10.1016/j.brainres.2014.09.006  1
2014 Cabezas R, Avila M, Gonzalez J, El-Bachá RS, Báez E, García-Segura LM, Jurado Coronel JC, Capani F, Cardona-Gomez GP, Barreto GE. Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease. Frontiers in Cellular Neuroscience. 8: 211. PMID 25136294 DOI: 10.3389/fncel.2014.00211  1
2014 Ghorbanpoor S, Garcia-Segura LM, Haeri-Rohani A, Khodagholi F, Jorjani M. Aromatase inhibition exacerbates pain and reactive gliosis in the dorsal horn of the spinal cord of female rats caused by spinothalamic tract injury. Endocrinology. 155: 4341-55. PMID 25105782 DOI: 10.1210/en.2014-1158  1
2014 Ávila Rodriguez M, Garcia-Segura LM, Cabezas R, Torrente D, Capani F, Gonzalez J, Barreto GE. Tibolone protects T98G cells from glucose deprivation. The Journal of Steroid Biochemistry and Molecular Biology. 144: 294-303. PMID 25086299 DOI: 10.1016/j.jsbmb.2014.07.009  1
2014 Scerbo MJ, Freire-Regatillo A, Cisternas CD, Brunotto M, Arevalo MA, Garcia-Segura LM, Cambiasso MJ. Neurogenin 3 mediates sex chromosome effects on the generation of sex differences in hypothalamic neuronal development. Frontiers in Cellular Neuroscience. 8: 188. PMID 25071448 DOI: 10.3389/fncel.2014.00188  1
2014 Rubio N, Arevalo MA, Cerciat M, Sanz-Rodriguez F, Unkila M, Garcia-Segura LM. Theiler's virus infection provokes the overexpression of genes coding for the chemokine Ip10 (CXCL10) in SJL/J murine astrocytes, which can be inhibited by modulators of estrogen receptors. Journal of Neurovirology. 20: 485-95. PMID 25052192 DOI: 10.1007/s13365-014-0273-3  1
2014 Barreto GE, Santos-Galindo M, Garcia-Segura LM. Selective estrogen receptor modulators regulate reactive microglia after penetrating brain injury. Frontiers in Aging Neuroscience. 6: 132. PMID 24999330 DOI: 10.3389/fnagi.2014.00132  1
2014 Gutierrez-Vargas JA, Muñoz-Manco JI, Garcia-Segura LM, Cardona-Gómez GP. GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia. Journal of Neuroscience Research. 92: 1529-48. PMID 24939000 DOI: 10.1002/jnr.23426  1
2014 Pietranera L, Brocca ME, Roig P, Lima A, Garcia-Segura LM, De Nicola AF. 17α-Oestradiol-induced neuroprotection in the brain of spontaneously hypertensive rats. Journal of Neuroendocrinology. 26: 310-20. PMID 24730417 DOI: 10.1111/jne.12151  1
2014 Olza-Fernández I, Marín Gabriel MA, Gil-Sanchez A, Garcia-Segura LM, Arevalo MA. Neuroendocrinology of childbirth and mother-child attachment: the basis of an etiopathogenic model of perinatal neurobiological disorders. Frontiers in Neuroendocrinology. 35: 459-72. PMID 24704390 DOI: 10.1016/j.yfrne.2014.03.007  1
2014 Mitro N, Cermenati G, Brioschi E, Abbiati F, Audano M, Giatti S, Crestani M, De Fabiani E, Azcoitia I, Garcia-Segura LM, Caruso D, Melcangi RC. Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy. The Journal of Steroid Biochemistry and Molecular Biology. 143: 115-21. PMID 24607810 DOI: 10.1016/j.jsbmb.2014.02.015  1
2014 Garcia-Segura LM, Perez-Marquez J. A new mathematical function to evaluate neuronal morphology using the Sholl analysis. Journal of Neuroscience Methods. 226: 103-9. PMID 24503022 DOI: 10.1016/j.jneumeth.2014.01.016  1
2014 Acaz-Fonseca E, Sanchez-Gonzalez R, Azcoitia I, Arevalo MA, Garcia-Segura LM. Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators. Molecular and Cellular Endocrinology. 389: 48-57. PMID 24444786 DOI: 10.1016/j.mce.2014.01.009  1
2014 Calabrese D, Giatti S, Romano S, Porretta-Serapiglia C, Bianchi R, Milanese M, Bonanno G, Caruso D, Viviani B, Gardoni F, Garcia-Segura LM, Melcangi RC. Diabetic neuropathic pain: a role for testosterone metabolites. The Journal of Endocrinology. 221: 1-13. PMID 24424289 DOI: 10.1530/JOE-13-0541  1
2014 Lopez-Rodriguez AB, Llorente-Berzal A, Garcia-Segura LM, Viveros MP. Sex-dependent long-term effects of adolescent exposure to THC and/or MDMA on neuroinflammation and serotoninergic and cannabinoid systems in rats. British Journal of Pharmacology. 171: 1435-47. PMID 24236988 DOI: 10.1111/bph.12519  1
2014 Melcangi RC, Giatti S, Calabrese D, Pesaresi M, Cermenati G, Mitro N, Viviani B, Garcia-Segura LM, Caruso D. Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions. Progress in Neurobiology. 113: 56-69. PMID 23958466 DOI: 10.1016/j.pneurobio.2013.07.006  1
2014 Astiz M, Acaz-Fonseca E, Garcia-Segura LM. Sex differences and effects of estrogenic compounds on the expression of inflammatory molecules by astrocytes exposed to the insecticide dimethoate. Neurotoxicity Research. 25: 271-85. PMID 23943137 DOI: 10.1007/s12640-013-9417-0  1
2013 Astiz M, Diz-Chaves Y, Garcia-Segura LM. Sub-chronic exposure to the insecticide dimethoate induces a proinflammatory status and enhances the neuroinflammatory response to bacterial lypopolysaccharide in the hippocampus and striatum of male mice. Toxicology and Applied Pharmacology. 272: 263-71. PMID 23891859 DOI: 10.1016/j.taap.2013.07.008  1
2013 Rubio N, Almanza A, Mercado F, Arévalo MÁ, Garcia-Segura LM, Vega R, Soto E. Upregulation of voltage-gated Ca2+ channels in mouse astrocytes infected with Theiler's murine encephalomyelitis virus (TMEV). Neuroscience. 247: 309-18. PMID 23742846 DOI: 10.1016/j.neuroscience.2013.05.049  1
2013 Grassi D, Lagunas N, Amorin M, Pinos H, Panzica GC, Garcia-Segura LM, Collado P. Estrogenic regulation of NADPH-diaphorase in the supraoptic and paraventricular nuclei under acute osmotic stress. Neuroscience. 248: 127-35. PMID 23707802 DOI: 10.1016/j.neuroscience.2013.05.024  1
2013 Caruso D, Pesaresi M, Abbiati F, Calabrese D, Giatti S, Garcia-Segura LM, Melcangi RC. Comparison of plasma and cerebrospinal fluid levels of neuroactive steroids with their brain, spinal cord and peripheral nerve levels in male and female rats. Psychoneuroendocrinology. 38: 2278-90. PMID 23706961 DOI: 10.1016/j.psyneuen.2013.04.016  1
2013 Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike CJ. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8891-7. PMID 23678130 DOI: 10.1523/JNEUROSCI.1350-13.2013  1
2013 Grassi D, Bellini MJ, Acaz-Fonseca E, Panzica G, Garcia-Segura LM. Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-α and -β. Endocrinology. 154: 2092-100. PMID 23584859 DOI: 10.1210/en.2012-2137  1
2013 Ruiz-Palmero I, Hernando M, Garcia-Segura LM, Arevalo MA. G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons. Molecular and Cellular Endocrinology. 372: 105-15. PMID 23545157 DOI: 10.1016/j.mce.2013.03.018  1
2013 Simon-Areces J, Acaz-Fonseca E, Ruiz-Palmero I, Garcia-Segura LM, Arevalo MA. A CRM1-mediated nuclear export signal is essential for cytoplasmic localization of neurogenin 3 in neurons. Plos One. 8: e55237. PMID 23383123 DOI: 10.1371/journal.pone.0055237  1
2013 Diz-Chaves Y, Astiz M, Bellini MJ, Garcia-Segura LM. Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice. Brain, Behavior, and Immunity. 28: 196-206. PMID 23207108 DOI: 10.1016/j.bbi.2012.11.013  1
2013 De Marinis E, Acaz-Fonseca E, Arevalo MA, Ascenzi P, Fiocchetti M, Marino M, Garcia-Segura LM. 17β-Oestradiol anti-inflammatory effects in primary astrocytes require oestrogen receptor β-mediated neuroglobin up-regulation. Journal of Neuroendocrinology. 25: 260-70. PMID 23190172 DOI: 10.1111/jne.12007  1
2013 Caruso D, Barron AM, Brown MA, Abbiati F, Carrero P, Pike CJ, Garcia-Segura LM, Melcangi RC. Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiology of Aging. 34: 1080-9. PMID 23122920 DOI: 10.1016/j.neurobiolaging.2012.10.007  1
2013 Grassi D, Lagunas N, Amorim M, Pinos H, Panzica G, Garcia-Segura LM, Collado P. Role of oestrogen receptors on the modulation of NADPH-diaphorase-positive cell number in supraoptic and paraventricular nuclei of ovariectomised female rats. Journal of Neuroendocrinology. 25: 244-50. PMID 22967140 DOI: 10.1111/j.1365-2826.2012.02387.x  1
2013 Giatti S, Boraso M, Abbiati F, Ballarini E, Calabrese D, Santos-Galindo M, Rigolio R, Pesaresi M, Caruso D, Viviani B, Cavaletti G, Garcia-Segura LM, Melcangi RC. Multimodal analysis in acute and chronic experimental autoimmune encephalomyelitis. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 8: 238-50. PMID 22870853 DOI: 10.1007/s11481-012-9385-9  1
2013 Diz-Chaves Y, Baquedano E, Frago LM, Chowen JA, Garcia-Segura LM, Arevalo MA. Maternal stress alters the developmental program of embryonic hippocampal neurons growing in vitro. Psychoneuroendocrinology. 38: 455-9. PMID 22832184 DOI: 10.1016/j.psyneuen.2012.07.001  1
2013 Arevalo MA, Santos-Galindo M, Acaz-Fonseca E, Azcoitia I, Garcia-Segura LM. Gonadal hormones and the control of reactive gliosis. Hormones and Behavior. 63: 216-21. PMID 22401743 DOI: 10.1016/j.yhbeh.2012.02.021  1
2013 Azcoitia I, Arevalo MA, Garcia-Segura LM. Brain Aromatase and Neuroprotection in Mammals Brain Aromatase, Estrogens, and Behavior. DOI: 10.1093/acprof:oso/9780199841196.003.0019  1
2012 Simon-Areces J, Dietrich MO, Hermes G, Garcia-Segura LM, Arevalo MA, Horvath TL. UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. Plos One. 7: e42911. PMID 22905184 DOI: 10.1371/journal.pone.0042911  1
2012 De Nicola AF, Brocca ME, Pietranera L, Garcia-Segura LM. Neuroprotection and sex steroid hormones: evidence of estradiol-mediated protection in hypertensive encephalopathy. Mini Reviews in Medicinal Chemistry. 12: 1081-9. PMID 22827218 DOI: 10.2174/138955712802762121  1
2012 Rubio N, Garcia-Segura LM, Arevalo MA. Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus. Journal of Neurovirology. 18: 354-63. PMID 22638909 DOI: 10.1007/s13365-012-0112-3  1
2012 Diz-Chaves Y, Pernía O, Carrero P, Garcia-Segura LM. Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice. Journal of Neuroinflammation. 9: 71. PMID 22520439 DOI: 10.1186/1742-2094-9-71  1
2012 Mitro N, Cermenati G, Giatti S, Abbiati F, Pesaresi M, Calabrese D, Garcia-Segura LM, Caruso D, Melcangi RC. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International. 60: 616-21. PMID 22406419 DOI: 10.1016/j.neuint.2012.02.025  1
2012 Barrera-Ocampo A, Gutierrez-Vargas J, Garcia-Segura LM, Cardona-Gómez GP. Glycogen synthase kinase-3β/β-catenin signaling in the rat hypothalamus during the estrous cycle. Journal of Neuroscience Research. 90: 1078-84. PMID 22331547 DOI: 10.1002/jnr.22816  1
2012 Velázquez-Zamora DA, Garcia-Segura LM, González-Burgos I. Effects of selective estrogen receptor modulators on allocentric working memory performance and on dendritic spines in medial prefrontal cortex pyramidal neurons of ovariectomized rats. Hormones and Behavior. 61: 512-7. PMID 22285935 DOI: 10.1016/j.yhbeh.2012.01.010  1
2012 Giatti S, Caruso D, Boraso M, Abbiati F, Ballarini E, Calabrese D, Pesaresi M, Rigolio R, Santos-Galindo M, Viviani B, Cavaletti G, Garcia-Segura LM, Melcangi RC. Neuroprotective effects of progesterone in chronic experimental autoimmune encephalomyelitis. Journal of Neuroendocrinology. 24: 851-61. PMID 22283602 DOI: 10.1111/j.1365-2826.2012.02284.x  1
2012 Panzica GC, Balthazart J, Frye CA, Garcia-Segura LM, Herbison AE, Mensah-Nyagan AG, McCarthy MM, Melcangi RC. Milestones on Steroids and the Nervous System: 10 years of basic and translational research. Journal of Neuroendocrinology. 24: 1-15. PMID 22188420 DOI: 10.1111/j.1365-2826.2011.02265.x  1
2012 González-Burgos I, Rivera-Cervantes MC, Velázquez-Zamora DA, Feria-Velasco A, Garcia-Segura LM. Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats. Neural Plasticity. 2012: 309494. PMID 22164341 DOI: 10.1155/2012/309494  1
2012 Cermenati G, Abbiati F, Cermenati S, Brioschi E, Volonterio A, Cavaletti G, Saez E, De Fabiani E, Crestani M, Garcia-Segura LM, Melcangi RC, Caruso D, Mitro N. Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation. Journal of Lipid Research. 53: 300-10. PMID 22158827 DOI: 10.1194/jlr.M021188  1
2012 Diz-Chaves Y, Kwiatkowska-Naqvi A, Von Hülst H, Pernía O, Carrero P, Garcia-Segura LM. Behavioral effects of estradiol therapy in ovariectomized rats depend on the age when the treatment is initiated. Experimental Gerontology. 47: 93-9. PMID 22075533 DOI: 10.1016/j.exger.2011.10.008  1
2012 Calmarza-Font I, Lagunas N, Garcia-Segura LM. Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress. Behavioural Brain Research. 227: 287-90. PMID 22061801 DOI: 10.1016/j.bbr.2011.10.036  1
2012 Arevalo MA, Ruiz-Palmero I, Scerbo MJ, Acaz-Fonseca E, Cambiasso MJ, Garcia-Segura LM. Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances. The Journal of Steroid Biochemistry and Molecular Biology. 131: 52-6. PMID 21971420 DOI: 10.1016/j.jsbmb.2011.09.004  1
2012 Wandosell F, Varea O, Arevalo MA, Garcia-Segura LM. Oestradiol regulates β-catenin-mediated transcription in neurones. Journal of Neuroendocrinology. 24: 191-4. PMID 21722217 DOI: 10.1111/j.1365-2826.2011.02186.x  1
2012 Arevalo MA, Diz-Chaves Y, Santos-Galindo M, Bellini MJ, Garcia-Segura LM. Selective oestrogen receptor modulators decrease the inflammatory response of glial cells. Journal of Neuroendocrinology. 24: 183-90. PMID 21564348 DOI: 10.1111/j.1365-2826.2011.02156.x  1
2012 Azcoitia IT, Garcia-Segura LM. Hormones and the aging brain Handbook of Neuroendocrinology. 573-594. DOI: 10.1016/B978-0-12-375097-6.10026-5  1
2011 Melcangi RC, Garcia-Segura LM. Sex differences in the injured brain. Hormone Molecular Biology and Clinical Investigation. 7: 385-91. PMID 25961275 DOI: 10.1515/HMBCI.2011.112  0.48
2011 Melcangi RC, Giatti S, Pesaresi M, Calabrese D, Mitro N, Caruso D, Garcia-Segura LM. Role of neuroactive steroids in the peripheral nervous system. Frontiers in Endocrinology. 2: 104. PMID 22654839 DOI: 10.3389/fendo.2011.00104  1
2011 Arevalo MA, Ruiz-Palmero I, Simon-Areces J, Acaz-Fonseca E, Azcoitia I, Garcia-Segura LM. Estradiol meets notch signaling in developing neurons. Frontiers in Endocrinology. 2: 21. PMID 22654797 DOI: 10.3389/fendo.2011.00021  1
2011 Baquedano E, García-Cáceres C, Diz-Chaves Y, Lagunas N, Calmarza-Font I, Azcoitia I, Garcia-Segura LM, Argente J, Chowen JA, Frago LM. Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats. Plos One. 6: e27549. PMID 22096592 DOI: 10.1371/journal.pone.0027549  1
2011 Pesaresi M, Giatti S, Cavaletti G, Abbiati F, Calabrese D, Lombardi R, Bianchi R, Lauria G, Caruso D, Garcia-Segura LM, Melcangi RC. Sex-dimorphic effects of dehydroepiandrosterone in diabetic neuropathy. Neuroscience. 199: 401-9. PMID 21945035 DOI: 10.1016/j.neuroscience.2011.09.013  1
2011 Azcoitia I, Arevalo MA, De Nicola AF, Garcia-Segura LM. Neuroprotective actions of estradiol revisited. Trends in Endocrinology and Metabolism: Tem. 22: 467-73. PMID 21889354 DOI: 10.1016/j.tem.2011.08.002  1
2011 Simon-Areces J, Dopazo A, Dettenhofer M, Rodriguez-Tebar A, Garcia-Segura LM, Arevalo MA. Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons. Plos One. 6: e21825. PMID 21818269 DOI: 10.1371/journal.pone.0021825  1
2011 Santos-Galindo M, Acaz-Fonseca E, Bellini MJ, Garcia-Segura LM. Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide. Biology of Sex Differences. 2: 7. PMID 21745355 DOI: 10.1186/2042-6410-2-7  1
2011 Melcangi RC, Panzica G, Garcia-Segura LM. Neuroactive steroids: focus on human brain. Neuroscience. 191: 1-5. PMID 21704130 DOI: 10.1016/j.neuroscience.2011.06.024  1
2011 Rubio N, Cerciat M, Unkila M, Garcia-Segura LM, Arevalo MA. An in vitro experimental model of neuroinflammation: the induction of interleukin-6 in murine astrocytes infected with Theiler's murine encephalomyelitis virus, and its inhibition by oestrogenic receptor modulators. Immunology. 133: 360-9. PMID 21564094 DOI: 10.1111/j.1365-2567.2011.03448.x  1
2011 Lagunas N, Calmarza-Font I, Grassi D, Garcia-Segura LM. Estrogen receptor ligands counteract cognitive deficits caused by androgen deprivation in male rats. Hormones and Behavior. 59: 581-4. PMID 21376723 DOI: 10.1016/j.yhbeh.2011.02.014  1
2011 Bellini MJ, Hereñú CB, Goya RG, Garcia-Segura LM. Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide. Journal of Neuroinflammation. 8: 21. PMID 21371294 DOI: 10.1186/1742-2094-8-21  1
2011 Azcoitia I, Yague JG, Garcia-Segura LM. Estradiol synthesis within the human brain. Neuroscience. 191: 139-47. PMID 21320576 DOI: 10.1016/j.neuroscience.2011.02.012  1
2011 Tapia-González S, García-Segura LM, Tena-Sempere M, Frago LM, Castellano JM, Fuente-Martín E, García-Cáceres C, Argente J, Chowen JA. Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition. Journal of Neuroendocrinology. 23: 365-70. PMID 21314736 DOI: 10.1111/j.1365-2826.2011.02113.x  0.36
2011 López Rodríguez AB, Mateos Vicente B, Romero-Zerbo SY, Rodriguez-Rodriguez N, Bellini MJ, Rodriguez de Fonseca F, Bermudez-Silva FJ, Azcoitia I, Garcia-Segura LM, Viveros MP. Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors. Cerebral Cortex (New York, N.Y. : 1991). 21: 2046-55. PMID 21258044 DOI: 10.1093/cercor/bhq277  1
2011 Ruiz-Palmero I, Simon-Areces J, Garcia-Segura LM, Arevalo MA. Notch/neurogenin 3 signalling is involved in the neuritogenic actions of oestradiol in developing hippocampal neurones. Journal of Neuroendocrinology. 23: 355-64. PMID 21251092 DOI: 10.1111/j.1365-2826.2011.02110.x  1
2011 Pesaresi M, Giatti S, Cavaletti G, Abbiati F, Calabrese D, Bianchi R, Caruso D, Garcia-Segura LM, Melcangi RC. Sex differences in the manifestation of peripheral diabetic neuropathy in gonadectomized rats: a correlation with the levels of neuroactive steroids in the sciatic nerve. Experimental Neurology. 228: 215-21. PMID 21241692 DOI: 10.1016/j.expneurol.2011.01.005  1
2011 Pietranera L, Bellini MJ, Arévalo MA, Goya R, Brocca ME, Garcia-Segura LM, De Nicola AF. Increased aromatase expression in the hippocampus of spontaneously hypertensive rats: effects of estradiol administration. Neuroscience. 174: 151-9. PMID 21115103 DOI: 10.1016/j.neuroscience.2010.11.044  1
2011 Arevalo MA, Santos-Galindo M, Lagunas N, Azcoitia I, Garcia-Segura LM. Selective estrogen receptor modulators as brain therapeutic agents. Journal of Molecular Endocrinology. 46: R1-9. PMID 21071476 DOI: 10.1677/JME-10-0122  1
2011 Mendez P, Garcia-Segura LM, Muller D. Estradiol promotes spine growth and synapse formation without affecting pre-established networks. Hippocampus. 21: 1263-7. PMID 20928832 DOI: 10.1002/hipo.20875  1
2011 Viveros MP, Marco EM, López-Gallardo M, Garcia-Segura LM, Wagner EJ. Framework for sex differences in adolescent neurobiology: a focus on cannabinoids. Neuroscience and Biobehavioral Reviews. 35: 1740-51. PMID 20869396 DOI: 10.1016/j.neubiorev.2010.09.005  1
2011 Arévalo MA, Garcia-Segura LM, Azcoitia I. Interactions of Estradiol and Insulin-Like Growth Factor-I in Neuroprotection: Implications for Brain Aging and Neurodegeneration Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis. 1-11. DOI: 10.1002/9783527633968.ch1  1
2010 De Nicola AF, Pietranera L, Bellini MJ, Goya R, Brocca ME, Garcia-Segura LM. Protective effect of estrogens on the brain of rats with essential and endocrine hypertension. Hormone Molecular Biology and Clinical Investigation. 4: 549-57. PMID 25961231 DOI: 10.1515/HMBCI.2010.044  0.44
2010 De Marinis E, Ascenzi P, Pellegrini M, Galluzzo P, Bulzomi P, Arevalo MA, Garcia-Segura LM, Marino M. 17β-estradiol--a new modulator of neuroglobin levels in neurons: role in neuroprotection against Hâ‚‚Oâ‚‚-induced toxicity. Neuro-Signals. 18: 223-35. PMID 21335947 DOI: 10.1159/000323906  1
2010 Azcoitia I, Santos-Galindo M, Arevalo MA, Garcia-Segura LM. Role of astroglia in the neuroplastic and neuroprotective actions of estradiol. The European Journal of Neuroscience. 32: 1995-2002. PMID 21143654 DOI: 10.1111/j.1460-9568.2010.07516.x  1
2010 Caruso D, Pesaresi M, Maschi O, Giatti S, Garcia-Segura LM, Melcangi RC. Effect of short-and long-term gonadectomy on neuroactive steroid levels in the central and peripheral nervous system of male and female rats. Journal of Neuroendocrinology. 22: 1137-47. PMID 20819120 DOI: 10.1111/j.1365-2826.2010.02064.x  1
2010 Lagunas N, Calmarza-Font I, Diz-Chaves Y, Garcia-Segura LM. Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress. Hormones and Behavior. 58: 786-91. PMID 20691693 DOI: 10.1016/j.yhbeh.2010.07.014  1
2010 Amorim MA, Guerra-Araiza C, Pernía O, da Cruz e Silva EF, Garcia-Segura LM. Progesterone regulates the phosphorylation of protein phosphatases in the brain. Journal of Neuroscience Research. 88: 2826-32. PMID 20568292 DOI: 10.1002/jnr.22442  1
2010 Caruso D, D'Intino G, Giatti S, Maschi O, Pesaresi M, Calabrese D, Garcia-Segura LM, Calza L, Melcangi RC. Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis. Journal of Neurochemistry. 114: 921-32. PMID 20492360 DOI: 10.1111/j.1471-4159.2010.06825.x  1
2010 Garcia-Segura LM, Arévalo MA, Azcoitia I. Interactions of estradiol and insulin-like growth factor-I signalling in the nervous system: new advances. Progress in Brain Research. 181: 251-72. PMID 20478442 DOI: 10.1016/S0079-6123(08)81014-X  1
2010 van Gool SA, Wit JM, De Schutter T, De Clerck N, Postnov AA, Kremer Hovinga S, van Doorn J, Veiga SJ, Garcia-Segura LM, Karperien M. Impaired body weight and tail length gain and altered bone quality after treatment with the aromatase inhibitor exemestane in male rats. Hormone Research in PæDiatrics. 73: 376-85. PMID 20389109 DOI: 10.1159/000308171  1
2010 Rodrigues de Amorim MA, Garcia-Segura LM, Goya RG, Portiansky EL. Decrease in PTEN and increase in Akt expression and neuron size in aged rat spinal cord. Experimental Gerontology. 45: 457-63. PMID 20347952 DOI: 10.1016/j.exger.2010.03.015  1
2010 Grassi D, Amorim MA, Garcia-Segura LM, Panzica G. Estrogen receptor alpha is involved in the estrogenic regulation of arginine vasopressin immunoreactivity in the supraoptic and paraventricular nuclei of ovariectomized rats. Neuroscience Letters. 474: 135-9. PMID 20298751 DOI: 10.1016/j.neulet.2010.03.022  1
2010 Simon-Areces J, Membrive G, Garcia-Fernandez C, Garcia-Segura LM, Arevalo MA. Neurogenin 3 cellular and subcellular localization in the developing and adult hippocampus. The Journal of Comparative Neurology. 518: 1814-24. PMID 20235092 DOI: 10.1002/cne.22304  1
2010 Fernández-Galaz MC, Fernández-Agulló T, Carrascosa JM, Ros M, Garcia-Segura LM. Leptin accumulation in hypothalamic and dorsal raphe neurons is inversely correlated with brain serotonin content. Brain Research. 1329: 194-202. PMID 20211152 DOI: 10.1016/j.brainres.2010.02.085  1
2010 Saraceno GE, Bertolino ML, Galeano P, Romero JI, Garcia-Segura LM, Capani F. Estradiol therapy in adulthood reverses glial and neuronal alterations caused by perinatal asphyxia. Experimental Neurology. 223: 615-22. PMID 20206165 DOI: 10.1016/j.expneurol.2010.02.010  1
2010 van Gool SA, Wit JM, De Schutter T, De Clerck N, Postnov AA, Kremer Hovinga S, van Doorn J, Veiga SJ, Garcia-Segura LM, Karperien M. Marginal growth increase, altered bone quality and polycystic ovaries in female prepubertal rats after treatment with the aromatase inhibitor exemestane. Hormone Research in PæDiatrics. 73: 49-60. PMID 20190540 DOI: 10.1159/000271916  1
2010 Picazo O, Becerril-Montes A, Huidobro-Perez D, Garcia-Segura LM. Neuroprotective actions of the synthetic estrogen 17alpha-ethynylestradiol in the hippocampus. Cellular and Molecular Neurobiology. 30: 675-82. PMID 20044777 DOI: 10.1007/s10571-009-9490-3  1
2010 Arevalo MA, Santos-Galindo M, Bellini MJ, Azcoitia I, Garcia-Segura LM. Actions of estrogens on glial cells: Implications for neuroprotection. Biochimica Et Biophysica Acta. 1800: 1106-12. PMID 19818384 DOI: 10.1016/j.bbagen.2009.10.002  1
2010 Yague JG, Azcoitia I, DeFelipe J, Garcia-Segura LM, Muñoz A. Aromatase expression in the normal and epileptic human hippocampus. Brain Research. 1315: 41-52. PMID 19815003 DOI: 10.1016/j.brainres.2009.09.111  1
2010 Varea O, Arevalo MA, Garrido JJ, Garcia-Segura LM, Wandosell F, Mendez P. Interaction of estrogen receptors with insulin-like growth factor-I and Wnt signaling in the nervous system. Steroids. 75: 565-9. PMID 19778547 DOI: 10.1016/j.steroids.2009.09.006  1
2010 Giatti S, D'Intino G, Maschi O, Pesaresi M, Garcia-Segura LM, Calza L, Caruso D, Melcangi RC. Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels. Neurochemistry International. 56: 118-27. PMID 19772882 DOI: 10.1016/j.neuint.2009.09.009  1
2010 García-Cáceres C, Diz-Chaves Y, Lagunas N, Calmarza-Font I, Azcoitia I, Garcia-Segura LM, Frago LM, Argente J, Chowen JA. The weight gain response to stress during adulthood is conditioned by both sex and prenatal stress exposure Psychoneuroendocrinology. 35: 403-413. PMID 19726133 DOI: 10.1016/j.psyneuen.2009.08.001  1
2010 Cerciat M, Unkila M, Garcia-Segura LM, Arevalo MA. Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-γ-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro Glia. 58: 93-102. PMID 19533603 DOI: 10.1002/glia.20904  1
2010 Cosimo Melcangi R, Garcia-Segura LM. Sex-specific therapeutic strategies based on neuroactive steroids: In search for innovative tools for neuroprotection. Hormones and Behavior. 57: 2-11. PMID 19524584 DOI: 10.1016/j.yhbeh.2009.06.001  1
2010 Pesaresi M, Maschi O, Giatti S, Garcia-Segura LM, Caruso D, Melcangi RC. Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats. Hormones and Behavior. 57: 46-55. PMID 19422828 DOI: 10.1016/j.yhbeh.2009.04.008  1
2010 Etgen AM, Garcia-Segura LM. Estrogen regulation of neurotransmitter and growth factor signaling in the brain Hormones, Brain and Behavior Online. 1121-1163. DOI: 10.1016/B978-008088783-8.00033-4  1
2010 Melcangi RC, Garcia-Segura LM. Glial Steroid Metabolism Encyclopedia of Neuroscience. 871-876. DOI: 10.1016/B978-008045046-9.01745-9  1
2009 Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernía O, Carrero P, Azcoitia I, Garcia-Segura LM. Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology. 150: 5010-5. PMID 19797123 DOI: 10.1210/en.2009-0352  1
2009 Giatti S, Pesaresi M, Cavaletti G, Bianchi R, Carozzi V, Lombardi R, Maschi O, Lauria G, Garcia-Segura LM, Caruso D, Melcangi RC. Neuroprotective effects of a ligand of translocator protein-18kDa (Ro5-4864) in experimental diabetic neuropathy Neuroscience. 164: 520-529. PMID 19665520 DOI: 10.1016/j.neuroscience.2009.08.005  1
2009 Biamonte F, Assenza G, Marino R, D'Amelio M, Panteri R, Caruso D, Scurati S, Yague JG, Garcia-Segura LM, Cesa R, Strata P, Melcangi RC, Keller F. Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival. Neurobiology of Disease. 36: 103-15. PMID 19595767 DOI: 10.1016/j.nbd.2009.07.001  1
2009 Viveros MP, Llorente R, López-Gallardo M, Suarez J, Bermúdez-Silva F, De la Fuente M, Rodriguez de Fonseca F, Garcia-Segura LM. Sex-dependent alterations in response to maternal deprivation in rats. Psychoneuroendocrinology. 34: S217-26. PMID 19553026 DOI: 10.1016/j.psyneuen.2009.05.015  1
2009 DonCarlos LL, Azcoitia I, Garcia-Segura LM. Neuroprotective actions of selective estrogen receptor modulators Psychoneuroendocrinology. 34: S113-S122. PMID 19447561 DOI: 10.1016/j.psyneuen.2009.04.012  1
2009 Llorente R, Gallardo ML, Berzal AL, Prada C, Garcia-Segura LM, Viveros MP. Early maternal deprivation in rats induces gender-dependent effects on developing hippocampal and cerebellar cells. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 27: 233-41. PMID 19429388 DOI: 10.1016/j.ijdevneu.2009.01.002  1
2009 Garcia-Segura LM, Balthazart J. Steroids and neuroprotection: New advances. Frontiers in Neuroendocrinology. 30: v-ix. PMID 19393683 DOI: 10.1016/j.yfrne.2009.04.006  1
2009 Varea O, Garrido JJ, Dopazo A, Mendez P, Garcia-Segura LM, Wandosell F. Estradiol activates beta-catenin dependent transcription in neurons. Plos One. 4: e5153. PMID 19360103 DOI: 10.1371/journal.pone.0005153  1
2009 Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, Garcia-Segura LM, Naftolin F. Estrogens regulate posttranslational modification of neural cell adhesion molecule during the estrogen-induced gonadotropin surge. Endocrinology. 150: 2783-90. PMID 19282389 DOI: 10.1210/en.2008-0927  1
2009 Marin R, Díaz M, Alonso R, Sanz A, Arévalo MA, Garcia-Segura LM. Role of estrogen receptor alpha in membrane-initiated signaling in neural cells: interaction with IGF-1 receptor. The Journal of Steroid Biochemistry and Molecular Biology. 114: 2-7. PMID 19167493 DOI: 10.1016/j.jsbmb.2008.12.014  1
2009 Yague JG, Garcia-Segura LM, Azcoitia I. Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells Endocrine. 35: 252-261. PMID 19116788 DOI: 10.1007/s12020-008-9134-2  1
2009 Guerra-Araiza C, Amorim MA, Pinto-Almazán R, González-Arenas A, Campos MG, Garcia-Segura LM. Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain. Journal of Neuroscience Research. 87: 470-81. PMID 18752305 DOI: 10.1002/jnr.21848  1
2008 Garcia-Segura LM. Aromatase in the brain: Not just for reproduction anymore Journal of Neuroendocrinology. 20: 705-712. PMID 18601693 DOI: 10.1111/j.1365-2826.2008.01713.x  1
2008 Tapia-Gonzalez S, Carrero P, Pernia O, Garcia-Segura LM, Diz-Chaves Y. Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: Potential role of microglial ERs Journal of Endocrinology. 198: 219-230. PMID 18460549 DOI: 10.1677/JOE-07-0294  1
2008 Sanz A, Carrero P, Pernía O, Garcia-Segura LM. Pubertal maturation modifies the regulation of insulin-like growth factor-I receptor signaling by estradiol in the rat prefrontal cortex Developmental Neurobiology. 68: 1018-1028. PMID 18446778 DOI: 10.1002/dneu.20641  1
2008 Sarkey S, Azcoitia I, Garcia-Segura LM, Garcia-Ovejero D, DonCarlos LL. Classical androgen receptors in non-classical sites in the brain. Hormones and Behavior. 53: 753-64. PMID 18402960 DOI: 10.1016/j.yhbeh.2008.02.015  1
2008 Yague JG, Wang AC, Janssen WG, Hof PR, Garcia-Segura LM, Azcoitia I, Morrison JH. Aromatase distribution in the monkey temporal neocortex and hippocampus. Brain Research. 1209: 115-27. PMID 18402929 DOI: 10.1016/j.brainres.2008.02.061  1
2008 Garcia-Segura LM, Lorenz B, DonCarlos LL. The role of glia in the hypothalamus: implications for gonadal steroid feedback and reproductive neuroendocrine output. Reproduction (Cambridge, England). 135: 419-29. PMID 18367504 DOI: 10.1530/REP-07-0540  1
2008 Melcangi RC, Garcia-Segura LM, Mensah-Nyagan AG. Neuroactive steroids: State of the art and new perspectives Cellular and Molecular Life Sciences. 65: 777-797. PMID 18038216 DOI: 10.1007/s00018-007-7403-5  1
2008 Morissette M, Le Saux M, D'Astous M, Jourdain S, Al Sweidi S, Morin N, Estrada-Camarena E, Mendez P, Garcia-Segura LM, Di Paolo T. Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain. The Journal of Steroid Biochemistry and Molecular Biology. 108: 327-38. PMID 17936613 DOI: 10.1016/j.jsbmb.2007.09.011  1
2008 Caruso D, Scurati S, Maschi O, De Angelis L, Roglio I, Giatti S, Garcia-Segura LM, Melcangi RC. Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes. Neurochemistry International. 52: 560-8. PMID 17686551 DOI: 10.1016/j.neuint.2007.06.004  1
2008 Roglio I, Giatti S, Pesaresi M, Bianchi R, Cavaletti G, Lauria G, Garcia-Segura LM, Melcangi RC. Neuroactive steroids and peripheral neuropathy. Brain Research Reviews. 57: 460-9. PMID 17543391 DOI: 10.1016/j.brainresrev.2007.04.010  1
2008 Walf AA, Ciriza I, Garcia-Segura LM, Frye CA. Antisense oligodeoxynucleotides for estrogen receptor-beta and alpha attenuate estradiol's modulation of affective and sexual behavior, respectively. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 431-40. PMID 17443129 DOI: 10.1038/sj.npp.1301416  1
2008 Hajszan T, Hoyk Z, Garcia-Segura LM, Parducz A. Effects of estradiol and DHEA on morphological synaptic plasticity Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies For Research and Treatment. 171-185. DOI: 10.1007/978-1-4020-6854-6_8  1
2008 Melcangi RC, Garcia-Segura LM. Steroid metabolism in glial cells Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies For Research and Treatment. 43-59. DOI: 10.1007/978-1-4020-6854-6_2  1
2007 Veiga S, Carrero P, Pernia O, Azcoitia I, Garcia-Segura LM. Translocator protein 18 kDa is involved in the regulation of reactive gliosis. Glia. 55: 1426-36. PMID 17674368 DOI: 10.1002/glia.20558  1
2007 Darnaudéry M, Perez-Martin M, Del Favero F, Gomez-Roldan C, Garcia-Segura LM, Maccari S. Early motherhood in rats is associated with a modification of hippocampal function. Psychoneuroendocrinology. 32: 803-12. PMID 17640823 DOI: 10.1016/j.psyneuen.2007.05.012  1
2007 Naftolin F, Garcia-Segura LM, Horvath TL, Zsarnovszky A, Demir N, Fadiel A, Leranth C, Vondracek-Klepper S, Lewis C, Chang A, Parducz A. Estrogen-induced hypothalamic synaptic plasticity and pituitary sensitization in the control of the estrogen-induced gonadotrophin surge. Reproductive Sciences (Thousand Oaks, Calif.). 14: 101-16. PMID 17636222 DOI: 10.1177/1933719107301059  1
2007 Garcia-Segura LM, Diz-Chaves Y, Perez-Martin M, Darnaudéry M. Estradiol, insulin-like growth factor-I and brain aging. Psychoneuroendocrinology. 32: S57-61. PMID 17618061 DOI: 10.1016/j.psyneuen.2007.03.001  1
2007 Barreto G, Veiga S, Azcoitia I, Garcia-Segura LM, Garcia-Ovejero D. Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: Role of its metabolites, oestradiol and dihydrotestosterone European Journal of Neuroscience. 25: 3039-3046. PMID 17561817 DOI: 10.1111/j.1460-9568.2007.05563.x  1
2007 Alejandre-Gomez M, Garcia-Segura LM, Gonzalez-Burgos I. Administration of an inhibitor of estrogen biosynthesis facilitates working memory acquisition in male rats. Neuroscience Research. 58: 272-7. PMID 17467093 DOI: 10.1016/j.neures.2007.03.011  1
2007 Guerra-Araiza C, Amorim MA, Camacho-Arroyo I, Garcia-Segura LM. Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum. Developmental Neurobiology. 67: 510-20. PMID 17443805 DOI: 10.1002/dneu.20383  1
2007 Roglio I, Bianchi R, Giatti S, Cavaletti G, Caruso D, Scurati S, Crippa D, Garcia-Segura LM, Camozzi F, Lauria G, Melcangi RC. Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy Cellular and Molecular Life Sciences. 64: 1158-1168. PMID 17417742 DOI: 10.1007/s00018-007-7002-5  1
2007 Leonelli E, Bianchi R, Cavaletti G, Caruso D, Crippa D, Garcia-Segura LM, Lauria G, Magnaghi V, Roglio I, Melcangi RC. Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: A multimodal analysis Neuroscience. 144: 1293-1304. PMID 17187935 DOI: 10.1016/j.neuroscience.2006.11.014  1
2007 Csakvari E, Hoyk Z, Gyenes A, Garcia-Ovejero D, Garcia-Segura LM, Párducz A. Fluctuation of synapse density in the arcuate nucleus during the estrous cycle Neuroscience. 144: 1288-1292. PMID 17161546 DOI: 10.1016/j.neuroscience.2006.11.008  1
2007 Garcia-Segura LM, Sanz A, Mendez P. Cross-talk between IGF-I and estradiol in the brain: Focus on neuroprotection Neuroendocrinology. 84: 275-279. PMID 17124377 DOI: 10.1159/000097485  1
2007 DonCarlos LL, Azcoitia I, Garcia-Segura LM. In search of neuroprotective therapies based on the mechanisms of estrogens Expert Review of Endocrinology and Metabolism. 2: 387-397. DOI: 10.1586/17446651.2.3.387  1
2006 Mendez P, Wandosell F, Garcia-Segura LM. Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: Cellular and molecular mechanisms Frontiers in Neuroendocrinology. 27: 391-403. PMID 17049974 DOI: 10.1016/j.yfrne.2006.09.001  1
2006 Cardona-Gómez GP, Arango-Davila C, Gallego-Gómez JC, Barrera-Ocampo A, Pimienta H, Garcia-Segura LM. Estrogen dissociates Tau and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit in postischemic hippocampus. Neuroreport. 17: 1337-41. PMID 16951581 DOI: 10.1097/01.wnr.0000230508.78467.96  1
2006 Garcia-Segura LM, Melcangi RC. Steroids and glial cell function Glia. 54: 485-498. PMID 16906540 DOI: 10.1002/glia.20404  1
2006 Melcangi RC, Garcia-Segura LM. Therapeutic approaches to peripheral neuropathy based on neuroactive steroids Expert Review of Neurotherapeutics. 6: 1121-1125. PMID 16893339 DOI: 10.1586/14737175.6.8.1121  1
2006 Magnaghi V, Veiga S, Ballabio M, Gonzalez LC, Garcia-Segura LM, Melcangi RC. Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells Journal of the Peripheral Nervous System. 11: 111-118. PMID 16787508 DOI: 10.1111/j.1085-9489.2006.00075.x  1
2006 Ciriza I, Carrero P, Frye CA, Garcia-Segura LM. Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective. Journal of Neurobiology. 66: 916-28. PMID 16758493 DOI: 10.1002/neu.20293  1
2006 Veiga S, Leonelli E, Beelke M, Garcia-Segura LM, Melcangi RC. Neuroactive steroids prevent peripheral myelin alterations induced by diabetes Neuroscience Letters. 402: 150-153. PMID 16626861 DOI: 10.1016/j.neulet.2006.03.058  1
2006 Azcoitia I, Moreno A, Carrero P, Palacios S, Garcia-Segura LM. Neuroprotective effects of soy phytoestrogens in the rat brain Gynecological Endocrinology. 22: 63-69. PMID 16603429 DOI: 10.1080/09513590500519161  1
2006 Mendez P, Garcia-Segura LM. Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells. Endocrinology. 147: 3027-39. PMID 16497810 DOI: 10.1210/en.2005-1224  1
2006 D'Astous M, Mendez P, Morissette M, Garcia-Segura LM, Di Paolo T. Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Molecular Pharmacology. 69: 1492-8. PMID 16434614 DOI: 10.1124/mol.105.018671  1
2006 Yague JG, Muñoz A, de Monasterio-Schrader P, Defelipe J, Garcia-Segura LM, Azcoitia I. Aromatase expression in the human temporal cortex. Neuroscience. 138: 389-401. PMID 16426763 DOI: 10.1016/j.neuroscience.2005.11.054  1
2006 Lavaque E, Sierra A, Azcoitia I, Garcia-Segura LM. Steroidogenic acute regulatory protein in the brain Neuroscience. 138: 741-747. PMID 16338087 DOI: 10.1016/j.neuroscience.2005.05.060  1
2006 Lavaque E, Mayen A, Azcoitia I, Tena-Sempere M, Garcia-Segura LM. Sex differences, developmental changes, response to injury and cAMP regulation of the mRNA levels of steroidogenic acute regulatory protein, cytochrome P450scc, and aromatase in the olivocerebellar system Journal of Neurobiology. 66: 308-318. PMID 16329132 DOI: 10.1002/neu.20221  1
2006 DonCarlos LL, Sarkey S, Lorenz B, Azcoitia I, Garcia-Ovejero D, Huppenbauer C, Garcia-Segura LM. Novel cellular phenotypes and subcellular sites for androgen action in the forebrain Neuroscience. 138: 801-807. PMID 16310968 DOI: 10.1016/j.neuroscience.2005.06.020  1
2006 Darnaudéry M, Perez-Martin M, Bélizaire G, Maccari S, Garcia-Segura LM. Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats. Neurobiology of Aging. 27: 119-27. PMID 16298247 DOI: 10.1016/j.neurobiolaging.2005.01.008  1
2005 Mendez P, Cardona-Gomez GP, Garcia-Segura LM. Interactions of insulin-like growth factor-I and estrogen in the brain. Advances in Experimental Medicine and Biology. 567: 285-303. PMID 16370144 DOI: 10.1007/0-387-26274-1_12  1
2005 Lorenz B, Garcia-Segura LM, DonCarlos LL. Cellular phenotype of androgen receptor-immunoreactive nuclei in the developing and adult rat brain. The Journal of Comparative Neurology. 492: 456-68. PMID 16228996 DOI: 10.1002/cne.20763  1
2005 Veiga S, Azcoitia I, Garcia-Segura LM. Extragonadal synthesis of estradiol is protective against kainic acid excitotoxic damage to the hippocampus Neuroreport. 16: 1599-1603. PMID 16148753 DOI: 10.1097/01.wnr.0000179081.39659.7d  1
2005 Leonelli E, Yague JG, Ballabio M, Azcoitia I, Magnaghi V, Schumacher M, Garcia-Segura LM, Melcangi RC. Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats. Mechanisms of Ageing and Development. 126: 1159-63. PMID 16045970 DOI: 10.1016/j.mad.2005.06.001  1
2005 Alvarez-de-la-Rosa M, Silva I, Nilsen J, Pérez MM, García-Segura LM, Avila J, Naftolin F. Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease. Annals of the New York Academy of Sciences. 1052: 210-24. PMID 16024764 DOI: 10.1196/annals.1347.016  1
2005 Carswell HV, Dominiczak AF, Garcia-Segura LM, Harada N, Hutchison JB, Macrae IM. Brain aromatase expression after experimental stroke: topography and time course. The Journal of Steroid Biochemistry and Molecular Biology. 96: 89-91. PMID 15896953 DOI: 10.1016/j.jsbmb.2005.02.016  1
2005 Perez-Martin M, Salazar V, Castillo C, Ariznavarreta C, Azcoitia I, Garcia-Segura LM, Tresguerres JAF. Estradiol and soy extract increase the production of new cells in the dentate gyrus of old rats Experimental Gerontology. 40: 450-453. PMID 15885957 DOI: 10.1016/j.exger.2005.03.003  1
2005 Melcangi RC, Cavarretta ITR, Ballabio M, Leonelli E, Schenone A, Azcoitia I, Garcia-Segura LM, Magnaghi V. Peripheral nerves: A target for the action of neuroactive steroids Brain Research Reviews. 48: 328-338. PMID 15850671 DOI: 10.1016/j.brainresrev.2004.12.021  1
2005 Mendez P, Azcoitia I, Garcia-Segura LM. Interdependence of oestrogen and insulin-like growth factor-I in the brain: potential for analysing neuroprotective mechanisms. The Journal of Endocrinology. 185: 11-7. PMID 15817823 DOI: 10.1677/joe.1.06058  1
2005 Azcoitia I, Perez-Martin M, Salazar V, Castillo C, Ariznavarreta C, Garcia-Segura LM, Tresguerres JAF. Growth hormone prevents neuronal loss in the aged rat hippocampus Neurobiology of Aging. 26: 697-703. PMID 15708445 DOI: 10.1016/j.neurobiolaging.2004.06.007  1
2005 Veiga S, Azcoitia I, Garcia-Segura LM. Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity Journal of Neuroscience Research. 80: 129-137. PMID 15696538 DOI: 10.1002/jnr.20430  1
2004 Hoyk Z, Párducz A, Garcia-Segura LM. Dehydroepiandrosterone regulates astroglia reaction to denervation of olfactory glomeruli. Glia. 48: 207-16. PMID 15390121 DOI: 10.1002/glia.20070  0.36
2003 DonCarlos LL, Garcia-Ovejero D, Sarkey S, Garcia-Segura LM, Azcoitia I. Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat. Endocrinology. 144: 3632-8. PMID 12865346 DOI: 10.1210/en.2002-0105  1
2003 Horvath TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, Elsworth JD, Sotonyi P, Roth RH, Dietrich EH, Matthews RT, Barnstable CJ, Redmond DE. Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology. 144: 2757-60. PMID 12810526 DOI: 10.1210/en.2003-0163  1
2003 Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 37: 649-61. PMID 12597862 DOI: 10.1016/S0896-6273(03)00063-1  1
2002 Cardona-Gomez GP, Mendez P, Garcia-Segura LM. Synergistic interaction of estradiol and insulin-like growth factor-I in the activation of PI3K/Akt signaling in the adult rat hypothalamus. Brain Research. Molecular Brain Research. 107: 80-8. PMID 12414126  0.8
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