Mel B. Feany, MD PhD

Pathology Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States 
 Massachusetts General Hospital, Boston, MA 
 University of Wisconsin, Madison, Madison, WI 
In our laboratory we have created fruit fly models of human neurological diseases, including Alzheimer's disease, Parkinson's disease, and a number of less common disorders
"Mel Feany"
Mean distance: 15.91 (cluster 31)
Cross-listing: Neuropathology Tree

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Bardai FH, Ordonez DG, Bailey RM, et al. (2018) Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics. Plos Biology. 16: e2006265
Wang L, Xia J, Li J, et al. (2018) Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease. Nature Communications. 9: 1899
Ordonez DG, Lee MK, Feany MB. (2017) α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton. Neuron
Bardai FH, Wang L, Mutreja Y, et al. (2017) A conserved cytoskeletal signaling cascade mediates neurotoxicity of FTDP-17 tau mutations in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Etchegaray JI, Elguero EJ, Tran JA, et al. (2016) Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3170-83
Wang L, Hagemann TL, Messing A, et al. (2016) An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1445-55
Frost B, Bardai FH, Feany MB. (2015) Lamin Dysfunction Mediates Neurodegeneration in Tauopathies. Current Biology : Cb
Wang L, Hagemann TL, Kalwa H, et al. (2015) Nitric oxide mediates glial-induced neurodegeneration in Alexander disease. Nature Communications. 6: 8966
Frost B, Götz J, Feany MB. (2015) Connecting the dots between tau dysfunction and neurodegeneration. Trends in Cell Biology. 25: 46-53
Frost B, Hemberg M, Lewis J, et al. (2014) Tau promotes neurodegeneration through global chromatin relaxation. Nature Neuroscience. 17: 357-66
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