Mel B. Feany, MD PhD

Pathology Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States 
 Massachusetts General Hospital, Boston, MA 
 University of Wisconsin, Madison, Madison, WI 
In our laboratory we have created fruit fly models of human neurological diseases, including Alzheimer's disease, Parkinson's disease, and a number of less common disorders
"Mel Feany"
Mean distance: 15.91 (cluster 31)
Cross-listing: Neuropathology Tree

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Sarkar S, Feany MB. (2021) Precision medicine on the fly: using Drosophila to decipher gene-environment interactions in Parkinson's disease. Toxicological Sciences : An Official Journal of the Society of Toxicology
Sarkar S, Bardai F, Olsen AL, et al. (2021) Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo. Molecular Neurodegeneration. 16: 33
Lohr KM, Frost B, Scherzer C, et al. (2020) Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America
Sarkar S, Murphy MA, Dammer EB, et al. (2020) Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy. Npj Parkinson's Disease. 6: 40
Olsen AL, Feany MB. (2019) Glial α-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo. Glia
Olsen AL, Feany MB. (2019) PARP Inhibitors and Parkinson's Disease. The New England Journal of Medicine. 380: 492-494
Bardai FH, Ordonez DG, Bailey RM, et al. (2018) Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics. Plos Biology. 16: e2006265
Wang L, Xia J, Li J, et al. (2018) Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease. Nature Communications. 9: 1899
Ordonez DG, Lee MK, Feany MB. (2017) α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton. Neuron
Bardai FH, Wang L, Mutreja Y, et al. (2017) A conserved cytoskeletal signaling cascade mediates neurotoxicity of FTDP-17 tau mutations in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
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