Huaxi Xu, Ph.D.
Affiliations: | 2003- | SBP Medical Discovery Institute |
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Parents
Sign in to add mentor| Dennis Shields | grad student | 1988-1993 | (Cell Biology Tree) |
| Paul Greengard | post-doc | 1994-1998 | Rockefeller |
Children
Sign in to add trainee| Jessica Stupack | grad student | 2015-2020 | SBP |
| Timothy Y. Huang | post-doc | 2012-2020 | SBP Medical Discovery Institute (Cell Biology Tree) |
| Lu-Lin Jiang | post-doc | 2014-2020 | SBP Medical Discovery Institute |
| Xiaoguang Li | post-doc | 2015-2021 | SBP Medical Discovery Institute |
| Juan C. Piña-Crespo | research scientist | 2015-2020 | SBP Medical Discovery Institute |
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Publications
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| Du Y, Guo T, Hao Y, et al. (2024) PKCδ serves as a potential biomarker and therapeutic target for microglia-mediated neuroinflammation in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association |
| Zhang D, Zhang W, Ming C, et al. (2024) P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy. Neuron |
| Cui Q, Liang S, Li H, et al. (2023) SNX17 Mediates Dendritic Spine Maturation via p140Cap. Molecular Neurobiology |
| Lee CYD, De La Rocha AJ, Inouye K, et al. (2023) BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice. Biorxiv : the Preprint Server For Biology |
| Zhao Y, Zheng Q, Hong Y, et al. (2023) β-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice. Nature Neuroscience |
| Gao Y, Hong Y, Huang L, et al. (2023) β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function. Cell. 186: 1026-1038.e20 |
| Leng L, Yuan Z, Pan R, et al. (2022) Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance. Nature Metabolism |
| Zhao P, Xu Y, Jiang L, et al. (2022) A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science Translational Medicine. 14: eabq0095 |
| Zhu B, Liu Y, Hwang S, et al. (2022) Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Molecular Neurodegeneration. 17: 58 |
| Guo T, Pan X, Jiang G, et al. (2022) Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |