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Roderick MacKinnon - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Area:
Ion channels
Website:
https://www.rockefeller.edu/our-scientists/heads-of-laboratories/872-roderick-mackinnon/
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101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhao C, MacKinnon R. Molecular structure of an open human K channel. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34815345 DOI: 10.1073/pnas.2112267118  0.482
2021 Niu Y, Tao X, Vaisey G, Olinares PDB, Alwaseem H, Chait BT, MacKinnon R. Analysis of the mechanosensor channel functionality of TACAN. Elife. 10. PMID 34374644 DOI: 10.7554/eLife.71188  0.456
2019 Sun J, MacKinnon R. Structural Basis of Human KCNQ1 Modulation and Gating. Cell. PMID 31883792 DOI: 10.1016/J.Cell.2019.12.003  0.656
2019 Lee CH, MacKinnon R. Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell. 179: 1582-1589.e7. PMID 31787376 DOI: 10.1016/j.cell.2019.11.006  0.573
2019 Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R. The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier. Elife. 8. PMID 31674909 DOI: 10.7554/Elife.50403  0.78
2019 Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S. Force-induced conformational changes in PIEZO1. Nature. PMID 31435018 DOI: 10.1038/s41586-019-1499-2  0.383
2019 Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R. Author response: The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier Elife. DOI: 10.7554/Elife.50403.022  0.791
2018 Park E, MacKinnon R. Structure of the CLC-1 chloride channel from . Elife. 7. PMID 29809153 DOI: 10.7554/Elife.36629  0.654
2018 Lee CH, MacKinnon R. Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science (New York, N.Y.). 360: 508-513. PMID 29724949 DOI: 10.1126/science.aas9466  0.552
2018 Park E, MacKinnon R. Author response: Structure of the CLC-1 chloride channel from Homo sapiens Elife. DOI: 10.7554/Elife.36629.031  0.68
2017 Lee KPK, Chen J, MacKinnon R. Molecular structure of human KATP in complex with ATP and ADP. Elife. 6. PMID 29286281 DOI: 10.7554/Elife.32481  0.442
2017 Sun J, MacKinnon R. Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. Cell. 169: 1042-1050.e9. PMID 28575668 DOI: 10.1016/J.Cell.2017.05.019  0.557
2017 Wang W, MacKinnon R. Cryo-EM Structure of the Open Human Ether-à-go-go-Related K(+) Channel hERG. Cell. 169: 422-430.e10. PMID 28431243 DOI: 10.1016/j.cell.2017.03.048  0.504
2017 Hite RK, MacKinnon R. Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel. Cell. 168: 390-399.e11. PMID 28111072 DOI: 10.1016/J.Cell.2016.12.030  0.796
2017 Lee CH, MacKinnon R. Structures of the Human HCN1 Hyperpolarization-Activated Channel. Cell. 168: 111-120.e11. PMID 28086084 DOI: 10.1016/j.cell.2016.12.023  0.595
2016 Park E, Campbell EB, MacKinnon R. Structure of a CLC chloride ion channel by cryo-electron microscopy. Nature. PMID 28002411 DOI: 10.1038/Nature20812  0.676
2016 Hite RK, Tao X, MacKinnon R. Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel. Nature. PMID 27974801 DOI: 10.1038/Nature20775  0.773
2016 Tao X, Hite RK, MacKinnon R. Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel. Nature. PMID 27974795 DOI: 10.1038/Nature20608  0.778
2016 Su Z, Brown EC, Wang W, MacKinnon R. Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 27091997 DOI: 10.1073/pnas.1602815113  0.514
2016 Touhara KK, Wang W, MacKinnon R. The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers. Elife. 5. PMID 27074664 DOI: 10.7554/eLife.15750  0.457
2016 Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels. Elife. 5. PMID 27074662 DOI: 10.7554/Elife.15751  0.646
2016 Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Author response: Cooperative regulation by G proteins and Na+ of neuronal GIRK2 K+ channels Elife. DOI: 10.7554/Elife.15751.016  0.676
2015 Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R. Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel. Nature. PMID 26436452 DOI: 10.1038/Nature14958  0.837
2014 Brohawn SG, Campbell EB, MacKinnon R. Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature. 516: 126-30. PMID 25471887 DOI: 10.1038/Nature14013  0.809
2014 Hite RK, Butterwick JA, MacKinnon R. Phosphatidic acid modulation of Kv channel voltage sensor function. Elife. 3. PMID 25285449 DOI: 10.7554/Elife.04366  0.768
2014 Wang W, Whorton MR, MacKinnon R. Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system. Elife. 3: e03671. PMID 25049222 DOI: 10.7554/Elife.03671  0.505
2014 Brohawn SG, Su Z, MacKinnon R. Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 111: 3614-9. PMID 24550493 DOI: 10.1073/Pnas.1320768111  0.809
2014 Hite RK, Butterwick JA, MacKinnon R. Author response: Phosphatidic acid modulation of Kv channel voltage sensor function Elife. DOI: 10.7554/Elife.04366.017  0.762
2014 Wang W, Whorton MR, MacKinnon R. Author response: Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system Elife. DOI: 10.7554/Elife.03671.011  0.449
2013 Whorton MR, MacKinnon R. X-ray structure of the mammalian GIRK2-βγ G-protein complex. Nature. 498: 190-7. PMID 23739333 DOI: 10.1038/Nature12241  0.527
2013 Banerjee A, Lee A, Campbell E, Mackinnon R. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife. 2: e00594. PMID 23705070 DOI: 10.7554/Elife.00594  0.551
2013 Brohawn SG, Campbell EB, MacKinnon R. Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 2129-34. PMID 23341632 DOI: 10.1073/Pnas.1218950110  0.815
2012 Leonetti MD, Yuan P, Hsiung Y, Mackinnon R. Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 109: 19274-9. PMID 23129643 DOI: 10.1073/pnas.1215078109  0.514
2012 Feng L, Campbell EB, MacKinnon R. Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters. Proceedings of the National Academy of Sciences of the United States of America. 109: 11699-704. PMID 22753511 DOI: 10.1073/Pnas.1205764109  0.502
2012 Brohawn SG, del Mármol J, MacKinnon R. Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science (New York, N.Y.). 335: 436-41. PMID 22282805 DOI: 10.1126/Science.1213808  0.817
2012 Yuan P, Leonetti MD, Hsiung Y, MacKinnon R. Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Nature. 481: 94-7. PMID 22139424 DOI: 10.1038/nature10670  0.483
2011 Whorton MR, MacKinnon R. Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell. 147: 199-208. PMID 21962516 DOI: 10.1016/J.Cell.2011.07.046  0.534
2011 Hansen SB, Tao X, MacKinnon R. Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature. 477: 495-8. PMID 21874019 DOI: 10.1038/Nature10370  0.563
2010 Feng L, Campbell EB, Hsiung Y, MacKinnon R. Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science (New York, N.Y.). 330: 635-41. PMID 20929736 DOI: 10.1126/Science.1195230  0.552
2010 Love J, Mancia F, Shapiro L, Punta M, Rost B, Girvin M, Wang DN, Zhou M, Hunt JF, Szyperski T, Gouaux E, MacKinnon R, McDermott A, Honig B, Inouye M, et al. The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. Journal of Structural and Functional Genomics. 11: 191-9. PMID 20690043 DOI: 10.1007/S10969-010-9094-7  0.405
2010 Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science (New York, N.Y.). 329: 182-6. PMID 20508092 DOI: 10.1126/Science.1190414  0.704
2010 Tao X, Lee A, Limapichat W, Dougherty DA, MacKinnon R. A gating charge transfer center in voltage sensors. Science (New York, N.Y.). 328: 67-73. PMID 20360102 DOI: 10.1126/Science.1185954  0.436
2009 Tao X, Avalos JL, Chen J, MacKinnon R. Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science (New York, N.Y.). 326: 1668-74. PMID 20019282 DOI: 10.1126/Science.1180310  0.572
2009 Endeward B, Butterwick JA, MacKinnon R, Prisner TF. Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA. Journal of the American Chemical Society. 131: 15246-50. PMID 19919160 DOI: 10.1021/Ja904808N  0.354
2009 Lee SY, Banerjee A, MacKinnon R. Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. Plos Biology. 7: e47. PMID 19260762 DOI: 10.1371/Journal.Pbio.1000047  0.636
2009 Lee SY, Letts JA, MacKinnon R. Functional reconstitution of purified human Hv1 H+ channels. Journal of Molecular Biology. 387: 1055-60. PMID 19233200 DOI: 10.1016/J.Jmb.2009.02.034  0.679
2009 Lee SY, Banerjee A, Mackinnon R. Two separate interfaces between the Voltage sensor and pore are required for the function of Voltage-dependent K+ channels Plos Biology. 7: 0676-0686. DOI: 10.1371/journal.pbio.1000047-S.pdf  0.594
2008 Lee SY, Letts JA, Mackinnon R. Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. Proceedings of the National Academy of Sciences of the United States of America. 105: 7692-5. PMID 18509058 DOI: 10.1073/Pnas.0803277105  0.644
2007 Long SB, Tao X, Campbell EB, MacKinnon R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature. 450: 376-82. PMID 18004376 DOI: 10.1038/Nature06265  0.744
2007 Nishida M, Cadene M, Chait BT, MacKinnon R. Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. The Embo Journal. 26: 4005-15. PMID 17703190 DOI: 10.1038/Sj.Emboj.7601828  0.566
2007 Lockless SW, Zhou M, MacKinnon R. Structural and thermodynamic properties of selective ion binding in a K+ channel. Plos Biology. 5: e121. PMID 17472437 DOI: 10.1371/Journal.Pbio.0050121  0.796
2006 Schmidt D, Jiang QX, MacKinnon R. Phospholipids and the origin of cationic gating charges in voltage sensors. Nature. 444: 775-9. PMID 17136096 DOI: 10.1038/nature05416  0.683
2006 Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R. Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science (New York, N.Y.). 314: 1004-7. PMID 17095703 DOI: 10.1126/Science.1133415  0.523
2006 Valiyaveetil FI, Sekedat M, MacKinnon R, Muir TW. Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel. Journal of the American Chemical Society. 128: 11591-9. PMID 16939283 DOI: 10.1021/Ja0631955  0.461
2005 Ruta V, Chen J, MacKinnon R. Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel. Cell. 123: 463-75. PMID 16269337 DOI: 10.1016/j.cell.2005.08.041  0.702
2005 Lee SY, Lee A, Chen J, MacKinnon R. Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America. 102: 15441-6. PMID 16223877 DOI: 10.1073/Pnas.0507651102  0.648
2005 Long SB, Campbell EB, Mackinnon R. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (New York, N.Y.). 309: 897-903. PMID 16002581 DOI: 10.1126/Science.1116269  0.763
2005 Long SB, Campbell EB, Mackinnon R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science (New York, N.Y.). 309: 903-8. PMID 16002579 DOI: 10.1126/Science.1116270  0.746
2004 Valiyaveetil FI, Sekedat M, Mackinnon R, Muir TW. Glycine as a D-amino acid surrogate in the K(+)-selectivity filter. Proceedings of the National Academy of Sciences of the United States of America. 101: 17045-9. PMID 15563591 DOI: 10.1073/Pnas.0407820101  0.349
2004 Jiang QX, Wang DN, MacKinnon R. Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation. Nature. 430: 806-10. PMID 15306816 DOI: 10.1038/Nature02735  0.735
2004 Ruta V, MacKinnon R. Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry. 43: 10071-9. PMID 15287735 DOI: 10.1021/bi049463y  0.702
2004 Lee SY, MacKinnon R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature. 430: 232-5. PMID 15241419 DOI: 10.1038/Nature02632  0.63
2004 Valiyaveetil FI, Sekedat M, Muir TW, MacKinnon R. Semisynthesis of a functional K+ channel. Angewandte Chemie (International Ed. in English). 43: 2504-7. PMID 15127436 DOI: 10.1002/Anie.200453849  0.531
2004 Zhou M, MacKinnon R. A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. Journal of Molecular Biology. 338: 839-46. PMID 15099749 DOI: 10.1016/J.Jmb.2004.03.020  0.504
2003 Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R. The principle of gating charge movement in a voltage-dependent K+ channel. Nature. 423: 42-8. PMID 12721619 DOI: 10.1038/Nature01581  0.843
2003 Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R. X-ray structure of a voltage-dependent K+ channel. Nature. 423: 33-41. PMID 12721618 DOI: 10.1038/Nature01580  0.853
2003 Ruta V, Jiang Y, Lee A, Chen J, MacKinnon R. Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature. 422: 180-5. PMID 12629550 DOI: 10.1038/Nature01473  0.855
2002 Valiyaveetil FI, MacKinnon R, Muir TW. Semisynthesis and folding of the potassium channel KcsA. Journal of the American Chemical Society. 124: 9113-20. PMID 12149015 DOI: 10.1021/Ja0266722  0.335
2002 Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. The open pore conformation of potassium channels. Nature. 417: 523-6. PMID 12037560 DOI: 10.1038/417523A  0.781
2002 Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417: 515-22. PMID 12037559 DOI: 10.1038/417515A  0.785
2002 Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature. 415: 287-94. PMID 11796999 DOI: 10.1038/415287A  0.519
2001 Zhou M, Morais-Cabral JH, Mann S, MacKinnon R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature. 411: 657-61. PMID 11395760 DOI: 10.1038/35079500  0.65
2001 Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron. 29: 593-601. PMID 11301020 DOI: 10.1016/S0896-6273(01)00236-7  0.806
2000 Gulbis JM, Zhou M, Mann S, MacKinnon R. Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science (New York, N.Y.). 289: 123-7. PMID 10884227 DOI: 10.1126/Science.289.5476.123  0.517
2000 Jiang Y, MacKinnon R. The barium site in a potassium channel by x-ray crystallography. The Journal of General Physiology. 115: 269-72. PMID 10694255 DOI: 10.1085/Jgp.115.3.269  0.721
1999 Hille B, Armstrong CM, MacKinnon R. Ion channels: from idea to reality. Nature Medicine. 5: 1105-9. PMID 10502800 DOI: 10.1038/13415  0.522
1999 Morrill JA, MacKinnon R. Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel. The Journal of General Physiology. 114: 71-83. PMID 10398693 DOI: 10.1085/jgp.114.1.71  0.483
1998 Morais Cabral JH, Lee A, Cohen SL, Chait BT, Li M, Mackinnon R. Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell. 95: 649-55. PMID 9845367 DOI: 10.1016/S0092-8674(00)81635-9  0.492
1998 Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (New York, N.Y.). 280: 69-77. PMID 9525859 DOI: 10.1126/Science.280.5360.69  0.739
1998 MacKinnon R, Cohen SL, Kuo A, Lee A, Chait BT. Structural conservation in prokaryotic and eukaryotic potassium channels. Science (New York, N.Y.). 280: 106-9. PMID 9525854 DOI: 10.1126/Science.280.5360.106  0.572
1997 MacKinnon R, Doyle DA. Prokaryotes offer hope for potassium channel structural studies. Nature Structural Biology. 4: 877-9. PMID 9360597 DOI: 10.1038/Nsb1197-877  0.763
1997 Swartz KJ, MacKinnon R. Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron. 18: 675-82. PMID 9136775 DOI: 10.1016/S0896-6273(00)80307-4  0.542
1997 Swartz KJ, MacKinnon R. Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites. Neuron. 18: 665-73. PMID 9136774 DOI: 10.1016/S0896-6273(00)80306-2  0.591
1996 Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell. 85: 1067-76. PMID 8674113 DOI: 10.1016/S0092-8674(00)81307-0  0.655
1996 Aggarwal SK, MacKinnon R. Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron. 16: 1169-77. PMID 8663993 DOI: 10.1016/S0896-6273(00)80143-9  0.525
1996 Ranganathan R, Lewis JH, MacKinnon R. Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron. 16: 131-9. PMID 8562077 DOI: 10.1016/S0896-6273(00)80030-6  0.71
1995 Krezel AM, Kasibhatla C, Hidalgo P, MacKinnon R, Wagner G. Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. Protein Science : a Publication of the Protein Society. 4: 1478-89. PMID 8520473 DOI: 10.1002/pro.5560040805  0.549
1995 Swartz KJ, MacKinnon R. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron. 15: 941-9. PMID 7576642 DOI: 10.1016/0896-6273(95)90184-1  0.543
1994 Heginbotham L, Lu Z, Abramson T, MacKinnon R. Mutations in the K+ channel signature sequence. Biophysical Journal. 66: 1061-7. PMID 8038378 DOI: 10.1016/S0006-3495(94)80887-2  0.514
1994 Gross A, Abramson T, MacKinnon R. Transfer of the scorpion toxin receptor to an insensitive potassium channel. Neuron. 13: 961-6. PMID 7946339 DOI: 10.1016/0896-6273(94)90261-5  0.559
1994 Lu Z, MacKinnon R. Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel. Nature. 371: 243-6. PMID 7915826 DOI: 10.1038/371243a0  0.561
1993 Perozo E, MacKinnon R, Bezanilla F, Stefani E. Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels. Neuron. 11: 353-8. PMID 8352943 DOI: 10.1016/0896-6273(93)90190-3  0.589
1993 MacKinnon R, Aldrich RW, Lee AW. Functional stoichiometry of Shaker potassium channel inactivation. Science (New York, N.Y.). 262: 757-9. PMID 7694359 DOI: 10.1126/Science.7694359  0.523
1992 Heginbotham L, Abramson T, MacKinnon R. A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science (New York, N.Y.). 258: 1152-5. PMID 1279807 DOI: 10.1126/Science.1279807  0.598
1991 Yellen G, Jurman ME, Abramson T, MacKinnon R. Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science (New York, N.Y.). 251: 939-42. PMID 2000494 DOI: 10.1126/Science.2000494  0.809
1990 MacKinnon R, Yellen G. Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science (New York, N.Y.). 250: 276-9. PMID 2218530 DOI: 10.1126/Science.2218530  0.707
1990 MacKinnon R, Heginbotham L, Abramson T. Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron. 5: 767-71. PMID 1702643 DOI: 10.1016/0896-6273(90)90335-D  0.578
1989 MacKinnon R, Latorre R, Miller C. Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel. Biochemistry. 28: 8092-9. PMID 2605175 DOI: 10.1021/Bi00446A020  0.644
1989 MacKinnon R, Miller C. Functional modification of a Ca2+-activated K+ channel by trimethyloxonium. Biochemistry. 28: 8087-92. PMID 2481495 DOI: 10.1021/Bi00446A019  0.662
1989 MacKinnon R, Miller C. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science (New York, N.Y.). 245: 1382-5. PMID 2476850 DOI: 10.1126/Science.2476850  0.576
1988 MacKinnon R, Reinhart PH, White MM. Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features. Neuron. 1: 997-1001. PMID 2483094 DOI: 10.1016/0896-6273(88)90156-0  0.682
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