| Year |
Citation |
Score |
| 2022 |
Greenwood EK, Angelova DM, Büchner HMI, Brown DR. The AICD fragment of APP initiates a FoxO3a mediated response via FANCD2. Molecular and Cellular Neurosciences. 122: 103760. PMID 35901928 DOI: 10.1016/j.mcn.2022.103760 |
0.303 |
|
| 2017 |
McDowall JS, Ntai I, Honeychurch KC, Hart JP, Colin P, Schneider BL, Brown DR. Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL. Molecular and Cellular Neurosciences. PMID 28811225 DOI: 10.1016/j.mcn.2017.08.001 |
0.316 |
|
| 2015 |
Pass R, Frudd K, Barnett JP, Blindauer CA, Brown DR. Prion infection in cells is abolished by a mutated manganese transporter but shows no relation to zinc. Molecular and Cellular Neurosciences. 68: 186-93. PMID 26253862 DOI: 10.1016/j.mcn.2015.08.004 |
0.371 |
|
| 2015 |
Goñi F, Mathiason CK, Yim L, Wong K, Hayes-Klug J, Nalls A, Peyser D, Estevez V, Denkers N, Xu J, Osborn DA, Miller KV, Warren RJ, Brown DR, Chabalgoity JA, et al. Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease. Vaccine. 33: 726-33. PMID 25539804 DOI: 10.1016/J.Vaccine.2014.11.035 |
0.325 |
|
| 2014 |
Cichon AC, Brown DR. Nrf-2 regulation of prion protein expression is independent of oxidative stress. Molecular and Cellular Neurosciences. 63: 31-7. PMID 25242137 DOI: 10.1016/j.mcn.2014.09.001 |
0.415 |
|
| 2014 |
Walsh KP, Minamide LS, Kane SJ, Shaw AE, Brown DR, Pulford B, Zabel MD, Lambeth JD, Kuhn TB, Bamburg JR. Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons. Plos One. 9: e95995. PMID 24760020 DOI: 10.1371/Journal.Pone.0095995 |
0.368 |
|
| 2013 |
Brown DR. α-Synuclein as a ferrireductase. Biochemical Society Transactions. 41: 1513-7. PMID 24256246 DOI: 10.1042/BST20130130 |
0.453 |
|
| 2013 |
Wright JA, McHugh PC, Pan S, Cunningham A, Brown DR. Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level. Molecular and Cellular Neurosciences. 57: 33-41. PMID 24080388 DOI: 10.1016/j.mcn.2013.09.002 |
0.545 |
|
| 2013 |
Younan ND, Sarell CJ, Davies P, Brown DR, Viles JH. The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1847-58. PMID 23335053 DOI: 10.1096/Fj.12-222588 |
0.567 |
|
| 2012 |
McHugh PC, Wright JA, Williams RJ, Brown DR. Prion protein expression alters APP cleavage without interaction with BACE-1. Neurochemistry International. 61: 672-80. PMID 22796214 DOI: 10.1016/j.neuint.2012.07.002 |
0.646 |
|
| 2012 |
Younan ND, Nadal RC, Davies P, Brown DR, Viles JH. Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway. The Journal of Biological Chemistry. 287: 28263-75. PMID 22654104 DOI: 10.1074/Jbc.M112.354779 |
0.563 |
|
| 2012 |
Meloni G, Crameri A, Fritz G, Davies P, Brown DR, Kroneck PM, Vašák M. The catalytic redox activity of prion protein-Cu(II) is controlled by metal exchange with the Zn(II) -thiolate clusters of Zn(7) metallothionein-3. Chembiochem : a European Journal of Chemical Biology. 13: 1261-5. PMID 22615124 DOI: 10.1002/Cbic.201200198 |
0.555 |
|
| 2012 |
Hesketh S, Thompsett AR, Brown DR. Prion protein polymerisation triggered by manganese-generated prion protein seeds. Journal of Neurochemistry. 120: 177-89. PMID 22007749 DOI: 10.1111/j.1471-4159.2011.07540.x |
0.36 |
|
| 2012 |
Brown DR. Prion protein Peptide : agents of death for neurons. Methods in Molecular Medicine. 59: 51-70. PMID 21374498 DOI: 10.1385/1-59259-134-5:51 |
0.31 |
|
| 2012 |
Brown DR, Jones IM. A function for the prion protein? Methods in Molecular Medicine. 59: 31-50. PMID 21374497 DOI: 10.1385/1-59259-134-5:31 |
0.32 |
|
| 2011 |
Mot AI, Wedd AG, Sinclair L, Brown DR, Collins SJ, Brazier MW. Metal attenuating therapies in neurodegenerative disease. Expert Review of Neurotherapeutics. 11: 1717-45. PMID 22091597 DOI: 10.1586/Ern.11.170 |
0.576 |
|
| 2011 |
Davies P, McHugh PC, Hammond VJ, Marken F, Brown DR. Contribution of individual histidines to prion protein copper binding. Biochemistry. 50: 10781-91. PMID 22039779 DOI: 10.1021/Bi2012349 |
0.585 |
|
| 2011 |
Younan ND, Klewpatinond M, Davies P, Ruban AV, Brown DR, Viles JH. Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein. Journal of Molecular Biology. 410: 369-82. PMID 21619885 DOI: 10.1016/J.Jmb.2011.05.013 |
0.58 |
|
| 2011 |
Brown DR. Prions and manganese: A maddening beast. Metallomics : Integrated Biometal Science. 3: 229-38. PMID 21390367 DOI: 10.1039/c0mt00047g |
0.391 |
|
| 2011 |
McHugh PC, Wright JA, Brown DR. Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1. Plos One. 6: e17354. PMID 21386983 DOI: 10.1371/journal.pone.0017354 |
0.514 |
|
| 2011 |
Davies P, Moualla D, Brown DR. Alpha-synuclein is a cellular ferrireductase. Plos One. 6: e15814. PMID 21249223 DOI: 10.1371/Journal.Pone.0015814 |
0.557 |
|
| 2011 |
Davies P, Wang X, Sarell CJ, Drewett A, Marken F, Viles JH, Brown DR. The synucleins are a family of redox-active copper binding proteins. Biochemistry. 50: 37-47. PMID 21117662 DOI: 10.1021/Bi101582P |
0.635 |
|
| 2010 |
Brown DR. Metalloproteins and neuronal death. Metallomics : Integrated Biometal Science. 2: 186-94. PMID 21069156 DOI: 10.1039/b912601e |
0.369 |
|
| 2010 |
Brown DR. Oligomeric alpha-synuclein and its role in neuronal death. Iubmb Life. 62: 334-9. PMID 20209636 DOI: 10.1002/iub.316 |
0.336 |
|
| 2010 |
Wang X, Moualla D, Wright JA, Brown DR. Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity. Journal of Neurochemistry. 113: 704-14. PMID 20141569 DOI: 10.1111/J.1471-4159.2010.06638.X |
0.666 |
|
| 2009 |
Brown DR. Gene regulation as a potential avenue for the treatment of neurodegenerative disorders. Expert Opinion On Drug Discovery. 4: 515-24. PMID 23485084 DOI: 10.1517/17460440902849237 |
0.307 |
|
| 2009 |
Davies P, Brown DR. Manganese enhances prion protein survival in model soils and increases prion infectivity to cells. Plos One. 4: e7518. PMID 19844576 DOI: 10.1371/Journal.Pone.0007518 |
0.566 |
|
| 2009 |
Wright JA, McHugh PC, Stockbridge M, Lane S, Kralovicova S, Brown DR. Activation and repression of prion protein expression by key regions of intron 1. Cellular and Molecular Life Sciences : Cmls. 66: 3809-20. PMID 19756378 DOI: 10.1007/s00018-009-0154-8 |
0.611 |
|
| 2009 |
Nadal RC, Davies P, Brown DR, Viles JH. Evaluation of copper2+ affinities for the prion protein. Biochemistry. 48: 8929-31. PMID 19697960 DOI: 10.1021/Bi9011397 |
0.594 |
|
| 2009 |
Madine J, Wang X, Brown DR, Middleton DA. Evaluation of beta-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation. Chembiochem : a European Journal of Chemical Biology. 10: 1982-7. PMID 19591188 DOI: 10.1002/Cbic.200900219 |
0.431 |
|
| 2009 |
Brown DR. Brain proteins that mind metals: a neurodegenerative perspective. Dalton Transactions (Cambridge, England : 2003). 4069-76. PMID 19452053 DOI: 10.1039/b822135a |
0.381 |
|
| 2009 |
Chang B, Gray P, Piltch M, Bulgin MS, Sorensen-Melson S, Miller MW, Davies P, Brown DR, Coughlin DR, Rubenstein R. Surround optical fiber immunoassay (SOFIA): an ultra-sensitive assay for prion protein detection. Journal of Virological Methods. 159: 15-22. PMID 19442839 DOI: 10.1016/J.Jviromet.2009.02.019 |
0.531 |
|
| 2009 |
Stevens DJ, Walter ED, RodrÃguez A, Draper D, Davies P, Brown DR, Millhauser GL. Early onset prion disease from octarepeat expansion correlates with copper binding properties. Plos Pathogens. 5: e1000390. PMID 19381258 DOI: 10.1371/Journal.Ppat.1000390 |
0.596 |
|
| 2009 |
Wright JA, Wang X, Brown DR. Unique copper-induced oligomers mediate alpha-synuclein toxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2384-93. PMID 19325037 DOI: 10.1096/Fj.09-130039 |
0.596 |
|
| 2009 |
Brown DR. Metal binding to alpha-synuclein peptides and its contribution to toxicity. Biochemical and Biophysical Research Communications. 380: 377-81. PMID 19250637 DOI: 10.1016/j.bbrc.2009.01.103 |
0.345 |
|
| 2009 |
Kralovicova S, Fontaine SN, Alderton A, Alderman J, Ragnarsdottir KV, Collins SJ, Brown DR. The effects of prion protein expression on metal metabolism. Molecular and Cellular Neurosciences. 41: 135-47. PMID 19233277 DOI: 10.1016/j.mcn.2009.02.002 |
0.682 |
|
| 2009 |
Davies P, Marken F, Salter S, Brown DR. Thermodynamic and voltammetric characterization of the metal binding to the prion protein: insights into pH dependence and redox chemistry. Biochemistry. 48: 2610-9. PMID 19196019 DOI: 10.1021/Bi900170N |
0.615 |
|
| 2009 |
O'Sullivan DB, Jones CE, Abdelraheim SR, Brazier MW, Toms H, Brown DR, Viles JH. Dynamics of a truncated prion protein, PrP(113-231), from (15)N NMR relaxation: order parameters calculated and slow conformational fluctuations localized to a distinct region. Protein Science : a Publication of the Protein Society. 18: 410-23. PMID 19173221 DOI: 10.1002/pro.44 |
0.574 |
|
| 2009 |
Fontaine SN, Brown DR. Mechanisms of prion protein aggregation. Protein and Peptide Letters. 16: 14-26. PMID 19149668 DOI: 10.2174/092986609787049411 |
0.665 |
|
| 2008 |
Davies P, Fontaine SN, Moualla D, Wang X, Wright JA, Brown DR. Amyloidogenic metal-binding proteins: new investigative pathways. Biochemical Society Transactions. 36: 1299-303. PMID 19021544 DOI: 10.1042/Bst0361299 |
0.785 |
|
| 2008 |
Büchl A, Hawkesworth CJ, Ragnarsdottir KV, Brown DR. Re-partitioning of Cu and Zn isotopes by modified protein expression. Geochemical Transactions. 9: 11. PMID 18847486 DOI: 10.1186/1467-4866-9-11 |
0.318 |
|
| 2008 |
Haigh CL, Brown DR. Investigation of PrPC metabolism and function in live cells : methods for studying individual cells and cell populations. Methods in Molecular Biology (Clifton, N.J.). 459: 21-34. PMID 18576145 DOI: 10.1007/978-1-59745-234-2_2 |
0.704 |
|
| 2008 |
Goñi F, Prelli F, Schreiber F, Scholtzova H, Chung E, Kascsak R, Brown DR, Sigurdsson EM, Chabalgoity JA, Wisniewski T. High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice. Neuroscience. 153: 679-86. PMID 18407424 DOI: 10.1016/J.Neuroscience.2008.02.051 |
0.314 |
|
| 2008 |
Sellarajah S, Boussard C, Lekishvili T, Brown DR, Gilbert IH. Synthesis and testing of peptides for anti-prion activity. European Journal of Medicinal Chemistry. 43: 2418-27. PMID 18355947 DOI: 10.1016/j.ejmech.2008.01.041 |
0.305 |
|
| 2008 |
Brazier MW, Davies P, Player E, Marken F, Viles JH, Brown DR. Manganese binding to the prion protein. The Journal of Biological Chemistry. 283: 12831-9. PMID 18332141 DOI: 10.1074/Jbc.M709820200 |
0.691 |
|
| 2008 |
Davies P, Brown DR. The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function? The Biochemical Journal. 410: 237-44. PMID 18254729 DOI: 10.1042/Bj20071477 |
0.615 |
|
| 2008 |
Hesketh S, Sassoon J, Knight R, Brown DR. Elevated manganese levels in blood and CNS in human prion disease. Molecular and Cellular Neurosciences. 37: 590-8. PMID 18234506 DOI: 10.1016/j.mcn.2007.12.008 |
0.3 |
|
| 2008 |
Zhu F, Davies P, Thompsett AR, Kelly SM, Tranter GE, Hecht L, Isaacs NW, Brown DR, Barron LD. Raman optical activity and circular dichroism reveal dramatic differences in the influence of divalent copper and manganese ions on prion protein folding. Biochemistry. 47: 2510-7. PMID 18205409 DOI: 10.1021/Bi7022893 |
0.574 |
|
| 2008 |
Uppington KM, Brown DR. Resistance of cell lines to prion toxicity aided by phospho-ERK expression. Journal of Neurochemistry. 105: 842-52. PMID 18088369 DOI: 10.1111/j.1471-4159.2007.05192.x |
0.78 |
|
| 2008 |
Klewpatinond M, Davies P, Bowen S, Brown DR, Viles JH. Deconvoluting the Cu2+ binding modes of full-length prion protein. The Journal of Biological Chemistry. 283: 1870-81. PMID 18042548 DOI: 10.1074/Jbc.M708472200 |
0.573 |
|
| 2008 |
Wright JA, Brown DR. Alpha-synuclein and its role in metal binding: relevance to Parkinson's disease. Journal of Neuroscience Research. 86: 496-503. PMID 17705291 DOI: 10.1002/jnr.21461 |
0.603 |
|
| 2007 |
Uppington KM, Brown DR. Modelling neurodegeneration in prion disease - applications for drug development. Expert Opinion On Drug Discovery. 2: 777-88. PMID 23488996 DOI: 10.1517/17460441.2.6.777 |
0.779 |
|
| 2007 |
Webb S, Lekishvili T, Loeschner C, Sellarajah S, Prelli F, Wisniewski T, Gilbert IH, Brown DR. Mechanistic insights into the cure of prion disease by novel antiprion compounds. Journal of Virology. 81: 10729-41. PMID 17652397 DOI: 10.1128/Jvi.01075-07 |
0.329 |
|
| 2007 |
Brown DR. Copper and amyloid fibril formation. The Febs Journal. 274: 3755. PMID 17617228 DOI: 10.1111/j.1742-4658.2007.05915.x |
0.396 |
|
| 2007 |
Brown DR. Interactions between metals and alpha-synuclein--function or artefact? The Febs Journal. 274: 3766-74. PMID 17617226 DOI: 10.1111/j.1742-4658.2007.05917.x |
0.353 |
|
| 2007 |
Alderton A, Davies P, Illman K, Brown DR. Ancient conserved domain protein-1 binds copper and modifies its retention in cells. Journal of Neurochemistry. 103: 312-21. PMID 17608643 DOI: 10.1111/J.1471-4159.2007.04751.X |
0.595 |
|
| 2007 |
Thompsett AR, Brown DR. Dual polarisation interferometry analysis of copper binding to the prion protein: evidence for two folding states. Biochimica Et Biophysica Acta. 1774: 920-7. PMID 17573247 DOI: 10.1016/j.bbapap.2007.05.007 |
0.378 |
|
| 2007 |
Haigh CL, Wright JA, Brown DR. Regulation of prion protein expression by noncoding regions of the Prnp gene. Journal of Molecular Biology. 368: 915-27. PMID 17376480 DOI: 10.1016/j.jmb.2007.02.086 |
0.755 |
|
| 2007 |
Treiber C, Thompsett AR, Pipkorn R, Brown DR, Multhaup G. Real-time kinetics of discontinuous and highly conformational metal-ion binding sites of prion protein. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 12: 711-20. PMID 17345106 DOI: 10.1007/s00775-007-0220-3 |
0.317 |
|
| 2007 |
Butowt R, Davies P, Brown DR. Anterograde axonal transport of chicken cellular prion protein (PrPc) in vivo requires its N-terminal part. Journal of Neuroscience Research. 85: 2567-79. PMID 17335074 DOI: 10.1002/Jnr.21229 |
0.506 |
|
| 2007 |
Nadal RC, Abdelraheim SR, Brazier MW, Rigby SE, Brown DR, Viles JH. Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals. Free Radical Biology & Medicine. 42: 79-89. PMID 17157195 DOI: 10.1016/j.freeradbiomed.2006.09.019 |
0.608 |
|
| 2007 |
O'Sullivan DB, Jones CE, Abdelraheim SR, Thompsett AR, Brazier MW, Toms H, Brown DR, Viles JH. NMR characterization of the pH 4 beta-intermediate of the prion protein: the N-terminal half of the protein remains unstructured and retains a high degree of flexibility. The Biochemical Journal. 401: 533-40. PMID 16958619 DOI: 10.1042/BJ20060668 |
0.562 |
|
| 2006 |
Haigh CL, Brown DR. Regulation of prion protein expression: a potential site for therapeutic intervention in the transmissible spongiform encephalopathies. International Journal of Biomedical Science : Ijbs. 2: 315-23. PMID 23674999 |
0.694 |
|
| 2006 |
Lekishvili T, Hesketh S, Brazier MW, Brown DR. Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression. The European Journal of Neuroscience. 24: 3017-25. PMID 17156363 DOI: 10.1111/j.1460-9568.2006.05207.x |
0.552 |
|
| 2006 |
Zerovnik E, Skerget K, Tusek-Znidaric M, Loeschner C, Brazier MW, Brown DR. High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation. The Febs Journal. 273: 4250-63. PMID 16939620 DOI: 10.1111/j.1742-4658.2006.05426.x |
0.571 |
|
| 2006 |
Cheng F, Lindqvist J, Haigh CL, Brown DR, Mani K. Copper-dependent co-internalization of the prion protein and glypican-1. Journal of Neurochemistry. 98: 1445-57. PMID 16923158 DOI: 10.1111/j.1471-4159.2006.03981.x |
0.739 |
|
| 2006 |
Haigh CL, Brown DR. Prion protein reduces both oxidative and non-oxidative copper toxicity. Journal of Neurochemistry. 98: 677-89. PMID 16787422 DOI: 10.1111/j.1471-4159.2006.03906.x |
0.738 |
|
| 2006 |
Abdelraheim SR, Královicová S, Brown DR. Hydrogen peroxide cleavage of the prion protein generates a fragment able to initiate polymerisation of full length prion protein. The International Journal of Biochemistry & Cell Biology. 38: 1429-40. PMID 16595185 DOI: 10.1016/j.biocel.2006.02.007 |
0.365 |
|
| 2005 |
Thompsett AR, Abdelraheim SR, Daniels M, Brown DR. High affinity binding between copper and full-length prion protein identified by two different techniques. The Journal of Biological Chemistry. 280: 42750-8. PMID 16258172 DOI: 10.1074/jbc.M506521200 |
0.341 |
|
| 2005 |
Pan T, Chang B, Wong P, Li C, Li R, Kang SC, Robinson JD, Thompsett AR, Tein P, Yin S, Barnard G, McConnell I, Brown DR, Wisniewski T, Sy MS. An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates. Journal of Virology. 79: 12355-64. PMID 16160162 DOI: 10.1128/Jvi.79.19.12355-12364.2005 |
0.343 |
|
| 2005 |
Haigh CL, Edwards K, Brown DR. Copper binding is the governing determinant of prion protein turnover. Molecular and Cellular Neurosciences. 30: 186-96. PMID 16084105 DOI: 10.1016/j.mcn.2005.07.001 |
0.706 |
|
| 2005 |
Jones CE, Klewpatinond M, Abdelraheim SR, Brown DR, Viles JH. Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: the unstructured N terminus facilitates the coordination of six copper2+ ions at physiological concentrations. Journal of Molecular Biology. 346: 1393-407. PMID 15713489 DOI: 10.1016/j.jmb.2004.12.043 |
0.327 |
|
| 2005 |
Brown DR. The use of peptides that pick up prions: Protection or poison? Expert Opinion On Therapeutic Patents. 15: 1287-1290. DOI: 10.1517/13543776.15.9.1287 |
0.326 |
|
| 2004 |
Tsenkova RN, Iordanova IK, Toyoda K, Brown DR. Prion protein fate governed by metal binding. Biochemical and Biophysical Research Communications. 325: 1005-12. PMID 15541389 DOI: 10.1016/j.bbrc.2004.10.135 |
0.371 |
|
| 2004 |
Lekishvili T, Sassoon J, Thompsett AR, Green A, Ironside JW, Brown DR. BSE and vCJD cause disturbance to uric acid levels. Experimental Neurology. 190: 233-44. PMID 15473996 DOI: 10.1016/j.expneurol.2004.07.002 |
0.345 |
|
| 2004 |
Brown DR, Kozlowski H. Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases. Dalton Transactions (Cambridge, England : 2003). 1907-17. PMID 15252577 DOI: 10.1039/b401985g |
0.39 |
|
| 2004 |
Jones CE, Abdelraheim SR, Brown DR, Viles JH. Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein. The Journal of Biological Chemistry. 279: 32018-27. PMID 15145944 DOI: 10.1074/jbc.M403467200 |
0.351 |
|
| 2004 |
Kang SC, Brown DR, Whiteman M, Li R, Pan T, Perry G, Wisniewski T, Sy MS, Wong BS. Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice. The Journal of Pathology. 203: 603-8. PMID 15095484 DOI: 10.1002/Path.1555 |
0.326 |
|
| 2004 |
Brown DR. Role of the prion protein in copper turnover in astrocytes Neurobiology of Disease. 15: 534-543. PMID 15056461 DOI: 10.1016/j.nbd.2003.11.009 |
0.337 |
|
| 2004 |
Sassoon J, Daniels M, Brown DR. Astrocytic regulation of NMDA receptor subunit composition modulates the toxicity of prion peptide PrP106-126 Molecular and Cellular Neuroscience. 25: 181-191. PMID 14962751 DOI: 10.1016/j.mcn.2003.09.019 |
0.321 |
|
| 2004 |
Brown DR, Guantieri V, Grasso G, Impellizzeri G, Pappalardo G, Rizzarelli E. Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region Journal of Inorganic Biochemistry. 98: 133-143. PMID 14659642 DOI: 10.1016/j.jinorgbio.2003.09.006 |
0.328 |
|
| 2003 |
Sigurdsson EM, Brown DR, Alim MA, Scholtzova H, Carp R, Meeker HC, Prelli F, Frangione B, Wisniewski T. Copper chelation delays the onset of prion disease. The Journal of Biological Chemistry. 278: 46199-202. PMID 14519758 DOI: 10.1074/Jbc.C300303200 |
0.349 |
|
| 2003 |
Turnbull S, Tabner BJ, Brown DR, Allsop D. Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126 Neuroreport. 14: 1743-1745. PMID 14512849 DOI: 10.1097/00001756-200309150-00017 |
0.353 |
|
| 2003 |
Brown DR. Prion protein expression modulates neuronal copper content Journal of Neurochemistry. 87: 377-385. PMID 14511115 DOI: 10.1046/j.1471-4159.2003.02046.x |
0.36 |
|
| 2003 |
Holme A, Daniels M, Sassoon J, Brown DR. A novel method of generating neuronal cell lines from gene-knockout mice to study prion protein membrane orientation European Journal of Neuroscience. 18: 571-579. PMID 12911753 DOI: 10.1046/j.1460-9568.2003.02780.x |
0.324 |
|
| 2003 |
Cui T, Daniels M, Wong BS, Li R, Sy MS, Sassoon J, Brown DR. Mapping the functional domain of the prion protein. European Journal of Biochemistry / Febs. 270: 3368-76. PMID 12899694 DOI: 10.1046/J.1432-1033.2003.03717.X |
0.36 |
|
| 2003 |
Wong BS, Li R, Sassoon J, Kang SC, Liu T, Pan T, Greenspan NS, Wisniewski T, Brown DR, Sy MS. Mapping the antigenicity of copper-treated cellular prion protein with the scrapie isoform. Cellular and Molecular Life Sciences : Cmls. 60: 1224-34. PMID 12861388 DOI: 10.1007/S00018-003-3057-0 |
0.339 |
|
| 2003 |
Turnbull S, Tabner BJ, Brown DR, Allsop D. Generation of hydrogen peroxide from mutant forms of the prion protein fragment PrP121-231. Biochemistry. 42: 7675-7681. PMID 12820876 DOI: 10.1021/Bi030036E |
0.33 |
|
| 2003 |
Cui T, Holme A, Sassoon J, Brown DR. Analysis of doppel protein toxicity. Molecular and Cellular Neurosciences. 23: 144-55. PMID 12799144 DOI: 10.1016/S1044-7431(03)00017-4 |
0.364 |
|
| 2003 |
Turnbull S, Tabner BJ, Brown DR, Allsop D. Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126. Neuroscience Letters. 336: 159-162. PMID 12505617 DOI: 10.1016/S0304-3940(02)01254-5 |
0.353 |
|
| 2003 |
Thackray AM, Madec JY, Wong E, Morgan-Warren R, Brown DR, Baron T, Bujdoso R. Detection of bovine spongiform encephalopathy, ovine scrapie prion-related protein (PrPSc) and normal PrPc by monoclonal antibodies raised to copper-refolded prion protein. The Biochemical Journal. 370: 81-90. PMID 12429022 DOI: 10.1042/BJ20021280 |
0.366 |
|
| 2003 |
Brown DR, Sassoon J. Copper-dependent functions for the prion protein. Molecular Biotechnology. 22: 165-78. PMID 12405264 DOI: 10.1385/MB:22:2:165 |
0.389 |
|
| 2003 |
Brown DR, Sassoon J. Role of glia in prion disease Advances in Molecular and Cell Biology. 31: 1085-1104. DOI: 10.1016/S1569-2558(03)31049-5 |
0.348 |
|
| 2002 |
Brown DR. Copper and prion diseases Biochemical Society Transactions. 30: 742-745. PMID 12196183 DOI: 10.1042/BST0300742 |
0.359 |
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| 2002 |
Wisniewski T, Brown DR, Sigurdsson EM. Therapeutics in Alzheimer's and prion diseases. Biochemical Society Transactions. 30: 574-8. PMID 12196140 DOI: 10.1042/Bst0300574 |
0.317 |
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| 2002 |
Brown DR. Mayhem of the multiple mechanisms: Modelling neurodegeneration in prion disease Journal of Neurochemistry. 82: 209-215. PMID 12124421 DOI: 10.1046/j.1471-4159.2002.01004.x |
0.338 |
|
| 2002 |
Brown DR. Molecular advances in understanding inherited prion diseases Molecular Neurobiology. 25: 287-302. PMID 12109876 DOI: 10.1385/MN:25:3:287 |
0.345 |
|
| 2002 |
Ellis V, Daniels M, Misra R, Brown DR. Plasminogen activation is stimulated by prion protein and regulated in a copper-dependent manner. Biochemistry. 41: 6891-6896. PMID 12033920 DOI: 10.1021/Bi025676G |
0.361 |
|
| 2002 |
Thackray AM, Knight R, Haswell SJ, Bujdoso R, Brown DR. Metal imbalance and compromised antioxidant function are early changes in prion disease. The Biochemical Journal. 362: 253-8. PMID 11829763 DOI: 10.1042/0264-6021:3620253 |
0.363 |
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| 2002 |
Brown DR, Nicholas RS, Canevari L. Lack of prion protein expression results in a neuronal phenotype sensitive to stress. Journal of Neuroscience Research. 67: 211-24. PMID 11782965 DOI: 10.1002/JNR.10118 |
0.341 |
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| 2002 |
THACKRAY AM, KNIGHT R, HASWELL SJ, BUJDOSO R, BROWN DR. Metal imbalance and compromised antioxidant function are early changes in prion disease Biochemical Journal. 362: 253-258. DOI: 10.1042/bj3620253 |
0.362 |
|
| 2001 |
Daniels M, Cereghetti GM, Brown DR. Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations. Febs Journal. 268: 6155-6164. PMID 11733010 DOI: 10.1046/J.0014-2956.2001.02567.X |
0.346 |
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| 2001 |
Wong BS, Brown DR, Pan T, Whiteman M, Liu T, Bu X, Li R, Gambetti P, Olesik J, Rubenstein R, Sy MS. Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities. Journal of Neurochemistry. 79: 689-98. PMID 11701772 DOI: 10.1046/J.1471-4159.2001.00625.X |
0.334 |
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| 2001 |
Wong BS, Chen SG, Colucci M, Xie Z, Pan T, Liu T, Li R, Gambetti P, Sy MS, Brown DR. Aberrant metal binding by prion protein in human prion disease. Journal of Neurochemistry. 78: 1400-8. PMID 11579148 DOI: 10.1046/J.1471-4159.2001.00522.X |
0.379 |
|
| 2001 |
Brown DR. Copper and prion disease. Brain Research Bulletin. 55: 165-73. PMID 11470312 DOI: 10.1016/S0361-9230(01)00453-1 |
0.4 |
|
| 2001 |
Wong BS, Liu T, Paisley D, Li R, Pan T, Chen SG, Perry G, Petersen RB, Smith MA, Melton DW, Gambetti P, Brown DR, Sy MS. Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function. Molecular and Cellular Neurosciences. 17: 768-75. PMID 11312611 DOI: 10.1006/Mcne.2001.0963 |
0.319 |
|
| 2001 |
Wong BS, Liu T, Li R, Pan T, Petersen RB, Smith MA, Gambetti P, Perry G, Manson JC, Brown DR, Sy MS. Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein. Journal of Neurochemistry. 76: 565-72. PMID 11208919 DOI: 10.1046/J.1471-4159.2001.00028.X |
0.313 |
|
| 2001 |
Brown DR. Prion and prejudice: Normal protein and the synapse Trends in Neurosciences. 24: 85-90. PMID 11164938 DOI: 10.1016/S0166-2236(00)01689-1 |
0.382 |
|
| 2001 |
Brown DR, Clive C, Haswell SJ. Antioxidant activity related to copper binding of native prion protein. Journal of Neurochemistry. 76: 69-76. PMID 11145979 DOI: 10.1046/J.1471-4159.2001.00009.X |
0.355 |
|
| 2000 |
Post K, Brown DR, Groschup M, Kretzschmar HA, Riesner D. Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro. Archives of Virology. Supplementum. 265-73. PMID 11214930 DOI: 10.1007/978-3-7091-6308-5_25 |
0.606 |
|
| 2000 |
Wong BS, Vénien-Bryan C, Williamson RA, Burton DR, Gambetti P, Sy MS, Brown DR, Jones IM. Copper refolding of prion protein. Biochemical and Biophysical Research Communications. 276: 1217-24. PMID 11027613 DOI: 10.1006/BBRC.2000.3604 |
0.371 |
|
| 2000 |
Hafiz FB, Brown DR. A model for the mechanism of astrogliosis in prion disease Molecular and Cellular Neurosciences. 16: 221-232. PMID 10995549 DOI: 10.1006/mcne.2000.0868 |
0.328 |
|
| 2000 |
Wong BS, Pan T, Liu T, Li R, Petersen RB, Jones IM, Gambetti P, Brown DR, Sy MS. Prion disease: A loss of antioxidant function? Biochemical and Biophysical Research Communications. 275: 249-52. PMID 10964653 DOI: 10.1006/Bbrc.2000.3158 |
0.372 |
|
| 2000 |
Brown DR, Iordanova IK, Wong BS, Vénien-Bryan C, Hafiz F, Glasssmith LL, Sy MS, Gambetti P, Jones IM, Clive C, Haswell SJ. Functional and structural differences between the prion protein from two alleles prnp(a) and prnp(b) of mouse. European Journal of Biochemistry / Febs. 267: 2452-9. PMID 10759872 DOI: 10.1046/J.1432-1327.2000.01275.X |
0.362 |
|
| 2000 |
Wong BS, Clive C, Haswell SJ, Williamson RA, Burton DR, Gambetti P, Sy MS, Jones IM, Brown DR. Copper has differential effect on prion protein with polymorphism of position 129. Biochemical and Biophysical Research Communications. 269: 726-31. PMID 10720484 DOI: 10.1006/BBRC.2000.2355 |
0.378 |
|
| 2000 |
Brown DR, Hafiz F, Glasssmith LL, Wong BS, Jones IM, Clive C, Haswell SJ. Consequences of manganese replacement of copper for prion protein function and proteinase resistance. The Embo Journal. 19: 1180-6. PMID 10716918 DOI: 10.1093/EMBOJ/19.6.1180 |
0.359 |
|
| 2000 |
McHattie SJ, Brown DR, Bird MM. Cellular uptake of the prion protein fragment PrP106-126 in vitro. Journal of Neurocytology. 28: 149-59. PMID 10590514 DOI: 10.1023/A:1007028323666 |
0.361 |
|
| 2000 |
Brown DR, Hafiz FB, Gunaratne RS. Native prion protein binds copper and is an antioxidant Biochemical Society Transactions. 28. DOI: 10.1042/Bst028A304 |
0.349 |
|
| 2000 |
Wong B, Brown DR, Clive C, Haswell S, Sy M, Gambetti P, Williamson RA, Burton DR, Jones IM. Effect of copper on recombinant mouse prion protein Biochemical Society Transactions. 28: A36-A36. DOI: 10.1042/Bst028A036B |
0.349 |
|
| 2000 |
BROWN DR. PrPSc-like prion protein peptide inhibits the function of cellular prion protein Biochemical Journal. 352: 511-518. DOI: 10.1042/BJ3520511 |
0.389 |
|
| 2000 |
Wong B, Clive C, Haswell SJ, Jones IM, Brown DR. Copper Has Differential Effect on Prion Protein with Polymorphism of Position 129 Biochemical and Biophysical Research Communications. 271: 842. DOI: 10.1006/BBRC.2000.2642 |
0.311 |
|
| 1999 |
Bürkle A, Kretzschmar HA, Brown DR. Poly(ADP-ribose) immunostaining to detect apoptosis induced by a neurotoxic fragment of prion protein. The Histochemical Journal. 31: 711-6. PMID 10646835 DOI: 10.1023/A:1003944314206 |
0.548 |
|
| 1999 |
Brown DR. Prion protein expression aids cellular uptake and veratridine-induced release of copper Journal of Neuroscience Research. 58: 717-725. PMID 10561700 DOI: 10.1002/(SICI)1097-4547(19991201)58:5<717::AID-JNR13>3.0.CO;2-S |
0.333 |
|
| 1999 |
Brown DR. Prion protein peptide neurotoxicity can be mediated by astrocytes Journal of Neurochemistry. 73: 1105-1113. PMID 10461901 DOI: 10.1046/j.1471-4159.1999.0731105.x |
0.346 |
|
| 1999 |
Wong BS, Wang H, Brown DR, Jones IM. Selective oxidation of methionine residues in prion proteins. Biochemical and Biophysical Research Communications. 259: 352-5. PMID 10362513 DOI: 10.1006/bbrc.1999.0802 |
0.373 |
|
| 1999 |
Brown DR, Mohn CM. Astrocytic glutamate uptake and prion protein expression. Glia. 25: 282-92. PMID 9932874 DOI: 10.1002/(SICI)1098-1136(19990201)25:3<282::AID-GLIA8>3.0.CO;2-N |
0.304 |
|
| 1999 |
BROWN DR, WONG B, HAFIZ F, CLIVE C, HASWELL SJ, JONES IM. Normal prion protein has an activity like that of superoxide dismutase Biochemical Journal. 344: 1-5. DOI: 10.1042/BJ3440001 |
0.357 |
|
| 1998 |
Brown DR. Prion protein-overexpressing cells show altered response to a neurotoxic prion protein peptide Journal of Neuroscience Research. 54: 331-340. PMID 9819138 DOI: 10.1002/(SICI)1097-4547(19981101)54:3<331::AID-JNR4>3.0.CO;2-K |
0.357 |
|
| 1998 |
Brown DR, Besinger A. Prion protein expression and superoxide dismutase activity. The Biochemical Journal. 423-9. PMID 9716501 DOI: 10.1042/BJ3340423 |
0.311 |
|
| 1998 |
Giese A, Brown DR, Groschup MH, Feldmann C, Haist I, Kretzschmar HA. Role of microglia in neuronal cell death in prion disease. Brain Pathology (Zurich, Switzerland). 8: 449-57. PMID 9669696 DOI: 10.1111/j.1750-3639.1998.tb00167.x |
0.578 |
|
| 1998 |
Brown DR, Schmidt B, Kretzschmar HA. A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia. Neurobiology of Disease. 4: 410-22. PMID 9666480 DOI: 10.1006/nbdi.1998.0169 |
0.556 |
|
| 1998 |
Brown DR, Besinger A, Herms JW, Kretzschmar HA. Microglial expression of the prion protein. Neuroreport. 9: 1425-9. PMID 9631441 DOI: 10.1097/00001756-199805110-00032 |
0.561 |
|
| 1998 |
Brown DR, Kretzschmar HA. The glio-toxic mechanism of alpha-aminoadipic acid on cultured astrocytes. Journal of Neurocytology. 27: 109-18. PMID 9609401 DOI: 10.1023/A:1006947322342 |
0.516 |
|
| 1998 |
Brown DR, Schmidt B, Kretzschmar HA. Prion protein fragment interacts with PrP-deficient cells. Journal of Neuroscience Research. 52: 260-7. PMID 9590434 DOI: 10.1002/(SICI)1097-4547(19980501)52:3<260::AID-JNR2>3.0.CO;2-B |
0.604 |
|
| 1998 |
Brown DR, Schmidt B, Kretzschmar HA. Effects of copper on survival of prion protein knockout neurons and glia. Journal of Neurochemistry. 70: 1686-93. PMID 9523587 DOI: 10.1046/J.1471-4159.1998.70041686.X |
0.61 |
|
| 1998 |
Brown DR, Schmidt B, Groschup MH, Kretzschmar HA. Prion protein expression in muscle cells and toxicity of a prion protein fragment. European Journal of Cell Biology. 75: 29-37. PMID 9523152 DOI: 10.1016/S0171-9335(98)80043-5 |
0.607 |
|
| 1998 |
Brown DR, Pitschke M, Riesner D, Kretzschmar HA. Cellular effects of a neurotoxic prion protein peptide are related to its ?-sheet content Neuroscience Research Communications. 23: 119-128. DOI: 10.1002/(SICI)1520-6769(199809/10)23:2<119::AID-NRC6>3.0.CO;2-G |
0.559 |
|
| 1997 |
Brown DR, Schmidt B, Kretzschmar HA. Effects of oxidative stress on prion protein expression in PC12 cells. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 15: 961-72. PMID 9641527 DOI: 10.1016/S0736-5748(97)00042-7 |
0.596 |
|
| 1997 |
Brown DR, Qin K, Herms JW, Madlung A, Manson J, Strome R, Fraser PE, Kruck T, von Bohlen A, Schulz-Schaeffer W, Giese A, Westaway D, Kretzschmar H. The cellular prion protein binds copper in vivo. Nature. 390: 684-7. PMID 9414160 DOI: 10.1038/37783 |
0.61 |
|
| 1997 |
Herms JW, Madlung A, Brown DR, Kretzschmar HA. Increase of intracellular free Ca2+ in microglia activated by prion protein fragment. Glia. 21: 253-7. PMID 9336239 DOI: 10.1002/(SICI)1098-1136(199710)21:2<253::AID-GLIA8>3.0.CO;2-7 |
0.508 |
|
| 1997 |
Brown DR, Schulz-Schaeffer WJ, Schmidt B, Kretzschmar HA. Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity. Experimental Neurology. 146: 104-12. PMID 9225743 DOI: 10.1006/exnr.1997.6505 |
0.562 |
|
| 1997 |
Brown DR, Kretzschmar HA. Microglia and prion disease: a review. Histology and Histopathology. 12: 883-92. PMID 9225170 DOI: 10.1002/jemt.1122 |
0.589 |
|
| 1997 |
Brown DR, Herms JW, Schmidt B, Kretzschmar HA. PrP and beta-amyloid fragments activate different neurotoxic mechanisms in cultured mouse cells. The European Journal of Neuroscience. 9: 1162-9. PMID 9215699 DOI: 10.1111/j.1460-9568.1997.tb01470.x |
0.61 |
|
| 1997 |
Kretzschmar HA, Giese A, Brown DR, Herms J, Keller B, Schmidt B, Groschup M. Cell death in prion disease. Journal of Neural Transmission. Supplementum. 50: 191-210. PMID 9120419 DOI: 10.1007/978-3-7091-6842-4_19 |
0.587 |
|
| 1996 |
Brown DR, Schmidt B, Kretzschmar HA. A neurotoxic prion protein fragment enhances proliferation of microglia but not astrocytes in culture. Glia. 18: 59-67. PMID 8891692 DOI: 10.1002/(SICI)1098-1136(199609)18:1<59::AID-GLIA6>3.0.CO;2-Z |
0.583 |
|
| 1996 |
Brown DR, Schmidt B, Kretzschmar HA. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature. 380: 345-7. PMID 8598929 DOI: 10.1038/380345a0 |
0.602 |
|
| 1995 |
Brown DR, Kretzschmar HA. Topographical reinnervation of the toad glutaeus muscle by axons of only one spinal nerve. Neuroreport. 6: 989-93. PMID 7632906 DOI: 10.1097/00001756-199505090-00010 |
0.407 |
|
| 1994 |
Brown DR, Herms J, Kretzschmar HA. Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment. Neuroreport. 5: 2057-60. PMID 7865744 DOI: 10.1097/00001756-199410270-00017 |
0.554 |
|
| 1989 |
Brown DR, Everett AW, Bennett MR. Compartmental and topographical distributions of axons in nerves to the amphibian (Bufo marinus) glutaeus muscle. The Journal of Comparative Neurology. 284: 231-41. PMID 2502565 DOI: 10.1002/cne.902840207 |
0.323 |
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