Thomas Wisniewski, MD - Publications

Affiliations: 
Pathology and Neurology New York University, New York, NY, United States 

273 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Leitner D, Kavanagh T, Kanshin E, Balcomb K, Pires G, Thierry M, Suazo JI, Schneider J, Ueberheide B, Drummond E, Wisniewski T. Differences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment. Acta Neuropathologica. 148: 9. PMID 39039355 DOI: 10.1007/s00401-024-02767-1  0.312
2024 Jacobs T, Jacobson SR, Fortea J, Berger JS, Vedvyas A, Marsh K, He T, Gutierrez-Jimenez E, Fillmore NR, Bubu OM, Gonzalez M, Figueredo L, Gaggi NL, Plaska CR, Pomara N, ... ... Wisniewski TM, et al. The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people. Research Square. PMID 38559231 DOI: 10.21203/rs.3.rs-4076789/v1  0.323
2023 Reiss AB, Muhieddine D, Jacob B, Mesbah M, Pinkhasov A, Gomolin IH, Stecker MM, Wisniewski T, De Leon J. Alzheimer's Disease Treatment: The Search for a Breakthrough. Medicina (Kaunas, Lithuania). 59. PMID 37374288 DOI: 10.3390/medicina59061084  0.315
2022 Parasoglou P, Osorio RS, Khegai O, Kovbasyuk Z, Miller M, Ho A, Dehkharghani S, Wisniewski T, Convit A, Mosconi L, Brown R. Phosphorus metabolism in the brain of cognitively normal midlife individuals at risk for Alzheimer's disease. Neuroimage. Reports. 2. PMID 36532654 DOI: 10.1016/j.ynirp.2022.100121  0.307
2022 Drummond E, Kavanagh T, Pires G, Marta-Ariza M, Kanshin E, Nayak S, Faustin A, Berdah V, Ueberheide B, Wisniewski T. The amyloid plaque proteome in early onset Alzheimer's disease and Down syndrome. Acta Neuropathologica Communications. 10: 53. PMID 35418158 DOI: 10.1186/s40478-022-01356-1  0.354
2021 Liu H, Kim C, Haldiman T, Sigurdson CJ, Nyström S, Nilsson KPR, Cohen ML, Wisniewski T, Hammarström P, Safar JG. Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease. The Journal of Biological Chemistry. 101267. PMID 34599965 DOI: 10.1016/j.jbc.2021.101267  0.341
2021 Wang M, Lv J, Huang X, Wisniewski T, Zhang W. High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer's disease associated with chronic platelet activation. Alzheimer's Research & Therapy. 13: 144. PMID 34454596 DOI: 10.1186/s13195-021-00890-9  0.329
2021 Patel AG, Nehete PN, Krivoshik SR, Pei X, Cho EL, Nehete BP, Ramani MD, Shao Y, Williams LE, Wisniewski T, Scholtzova H. Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer's disease pathology in aged squirrel monkeys. Brain : a Journal of Neurology. PMID 34128045 DOI: 10.1093/brain/awab129  0.328
2021 Boutajangout A, Zhang W, Kim J, Abdali WA, Prelli F, Wisniewski T. Passive Immunization With a Novel Monoclonal Anti-PrP Antibody TW1 in an Alzheimer's Mouse Model With Tau Pathology. Frontiers in Aging Neuroscience. 13: 640677. PMID 33716717 DOI: 10.3389/fnagi.2021.640677  0.3
2020 Dyakin VV, Wisniewski TM, Lajtha A. Chiral Interface of Amyloid Beta (Aβ): Relevance to Protein Aging, Aggregation and Neurodegeneration. Symmetry. 12. PMID 34327009 DOI: 10.3390/sym12040585  0.328
2020 Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M, Safar J, Ueberheide B, Wisniewski T. Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain : a Journal of Neurology. PMID 32812023 DOI: 10.1093/Brain/Awaa223  0.378
2020 Reiss AB, Glass AD, Wisniewski T, Wolozin B, Gomolin IH, Pinkhasov A, De Leon J, Stecker MM. Alzheimer's disease: many failed trials, so where do we go from here? Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 68: 1135-1140. PMID 32699179 DOI: 10.1136/Jim-2020-001297  0.439
2020 Hickman RA, Flowers XE, Wisniewski T. Primary Age-Related Tauopathy (PART): Addressing the Spectrum of Neuronal Tauopathic Changes in the Aging Brain. Current Neurology and Neuroscience Reports. 20: 39. PMID 32666342 DOI: 10.1007/S11910-020-01063-1  0.31
2020 Reisberg B, Shao Y, Moosavi M, Kenowsky S, Vedvyas A, Marsh K, Bao J, Buj M, Torossian C, Kluger A, Vedvyas G, Oo T, Malik F, Arain F, Masurkar AV, ... Wisniewski T, et al. Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders. 1-6. PMID 32388509 DOI: 10.1159/000507286  0.35
2020 Nehete PN, Williams LE, Chitta S, Nehete BP, Patel AG, Ramani MD, Wisniewski T, Scholtzova H. Class C CpG Oligodeoxynucleotide Immunomodulatory Response in Aged Squirrel Monkey (). Frontiers in Aging Neuroscience. 12: 36. PMID 32194391 DOI: 10.3389/Fnagi.2020.00036  0.371
2020 Devanand DP, Andrews H, Kreisl WC, Razlighi Q, Gershon A, Stern Y, Mintz A, Wisniewski T, Acosta E, Pollina J, Katsikoumbas M, Bell KL, Pelton GH, Deliyannides D, Prasad KM, et al. Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial. Bmj Open. 10: e032112. PMID 32034019 DOI: 10.1136/Bmjopen-2019-032112  0.401
2020 Wisniewski T, Drummond E. APOE-amyloid interaction: Therapeutic targets. Neurobiology of Disease. 104784. PMID 32027932 DOI: 10.1016/J.Nbd.2020.104784  0.439
2019 Pires G, McElligott S, Drusinsky S, Halliday G, Potier MC, Wisniewski T, Drummond E. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta Neuropathologica Communications. 7: 195. PMID 31796108 DOI: 10.1186/S40478-019-0848-6  0.444
2019 Wisniewski T, Drummond E. Future horizons in Alzheimer's disease research. Progress in Molecular Biology and Translational Science. 168: 223-241. PMID 31699317 DOI: 10.1016/Bs.Pmbts.2019.08.001  0.422
2019 Martino Adami PV, Nichtová Z, Weaver DB, Bartok A, Wisniewski T, Jones DR, Do Carmo S, Castaño EM, Cuello AC, Hajnóczky G, Morelli L. Perturbed mitochondria-ER contacts in live neurons modelling Alzheimer's disease amyloid pathology. Journal of Cell Science. PMID 31515277 DOI: 10.1242/Jcs.229906  0.394
2019 Wisniewski T. Follow-up of active Aβ immunization in Alzheimer disease. Nature Reviews. Neurology. PMID 31308505 DOI: 10.1038/S41582-019-0239-4  0.443
2019 Boutajangout A, Lindberg H, Awwad A, Paul A, Baitalmal R, Almokyad I, Höidén-Guthenberg I, Gunneriusson E, Frejd FY, Härd T, Löfblom J, Ståhl S, Wisniewski T. Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model. Frontiers in Aging Neuroscience. 11: 64. PMID 30967771 DOI: 10.3389/Fnagi.2019.00064  0.484
2019 Rubenstein R, Sharma DR, Chang B, Oumata N, Cam M, Vaucelle L, Lindberg MF, Chiu A, Wisniewski T, Wang KKW, Meijer L. Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation. Frontiers in Neurology. 10: 124. PMID 30915013 DOI: 10.3389/Fneur.2019.00124  0.38
2019 Lu H, Wang XD, Shi Z, Yue W, Zhang Y, Liu S, Liu S, Zhao L, Xiang L, Zhang Y, Guan Y, Su W, Li Z, Wang J, Wisniewski T, et al. Comparative analysis of cognitive impairment prevalence and its etiological subtypes in a rural area of northern China between 2010 and 2015. Scientific Reports. 9: 851. PMID 30696930 DOI: 10.1038/S41598-018-37286-Z  0.302
2019 Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M, Ueberheide B, Wisniewski T. P4-530: Phosphorylated Tau Interactome In The Human Alzheimer'S Disease Brain Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.08.077  0.39
2019 Drummond E, Berdah V, Nayak S, Pires G, Ueberheide B, Wisniewski T. P1-155: Differences In The Amyloid Plaque Proteome In Down Syndrome Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.710  0.347
2019 Pires G, Prelli F, Halliday GM, McElligott S, Drusinsky S, Wisniewski T, Drummond E. O4-01-06: Secernin-1 Is A Novel Phosphorylated Tau Binding Protein That Accumulates In Alzheimer'S Disease And Not In Other Tauopathies Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4745  0.369
2019 Goni F, Pires G, Marta-Ariza M, Wisniewski T. P1-082: THERAPEUTICALLY EFFICACIOUS ANTI-β-SHEET MONOCLONAL DOES NOT INDUCE MICROHEMORRHAGES OR INFLAMMATION IN TGSWDI AD MICE WITH EXTENSIVE VASCULAR AMYLOID, INCREASING CHANCES OF SAFE TRANSLATABILITY Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.107  0.398
2018 Zhu R, Pan YH, Sun L, Zhang T, Wang C, Ye S, Yang N, Lu T, Wisniewski T, Dang S, Zhang W. ADAMTS18 deficiency affects neuronal morphogenesis and reduces the levels of depression-like behaviors in mice. Neuroscience. PMID 30579834 DOI: 10.1016/J.Neuroscience.2018.12.025  0.304
2018 Herline K, Drummond E, Wisniewski T. Recent advancements toward therapeutic vaccines against alzheimer's disease. Expert Review of Vaccines. PMID 30005578 DOI: 10.1080/14760584.2018.1500905  0.471
2018 Herline K, Prelli F, Mehta P, MacMurray C, Goñi F, Wisniewski T. Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model. Alzheimer's Research & Therapy. 10: 54. PMID 29914551 DOI: 10.1186/S13195-018-0384-9  0.484
2018 Solesio ME, Peixoto PM, Debure L, Madamba SM, de Leon MJ, Wisniewski T, Pavlov EV, Fossati S. Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity. Aging Cell. e12787. PMID 29873184 DOI: 10.1111/Acel.12787  0.377
2018 Drummond E, Goñi F, Liu S, Prelli F, Scholtzova H, Wisniewski T. Potential Novel Approaches to Understand the Pathogenesis and Treat Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 29562516 DOI: 10.3233/Jad-179909  0.426
2018 Mehta PD, Patrick BA, Barshatzky M, Mehta SP, Frackowiak J, Mazur-Kolecka B, Wegiel J, Wisniewski T, Miller DL. Generation and Partial Characterization of Rabbit Monoclonal Antibody to Pyroglutamate Amyloid-β3-42 (pE3-Aβ). Journal of Alzheimer's Disease : Jad. PMID 29504532 DOI: 10.3233/Jad-170898  0.439
2018 Ramos-Cejudo J, Wisniewski T, Marmar C, Zetterberg H, Blennow K, de Leon MJ, Fossati S. Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link. Ebiomedicine. PMID 29396300 DOI: 10.1016/J.Ebiom.2018.01.021  0.425
2018 Goñi F, Martá-Ariza M, Herline K, Peyser D, Boutajangout A, Mehta P, Drummond E, Prelli F, Wisniewski T. Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model. Alzheimer's Research & Therapy. 10: 10. PMID 29378642 DOI: 10.1186/S13195-018-0337-3  0.458
2018 Drummond E, Nayak S, Pires G, Ueberheide B, Wisniewski T. Isolation of Amyloid Plaques and Neurofibrillary Tangles from Archived Alzheimer's Disease Tissue Using Laser-Capture Microdissection for Downstream Proteomics. Methods in Molecular Biology (Clifton, N.J.). 1723: 319-334. PMID 29344869 DOI: 10.1007/978-1-4939-7558-7_18  0.408
2018 Wenning G, Trojanowski JQ, Kaufmann H, Rocca WA, Wisniewski T, Low PA. Is Multiple System Atrophy An Infectious Disease? Annals of Neurology. PMID 29293269 DOI: 10.1002/Ana.25132  0.31
2018 Boutajangout A, Abdali W, Kim JST, Wisniewski T. P4-223: Passive Immunization With The Novel Monoclonal Anti-Prp Antibody Tw1 In An Alzheimer'S Mouse Model Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.07.044  0.335
2018 Drummond E, Pires G, Prelli F, McElligott S, Drusinsky S, Wisniewski T. P2-170: Secernin-1 Is A Novel Early Marker Of Neurofibrillary Tangles In Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.857  0.393
2018 Drummond E, Goni F, Prelli F, Scholtzova H, Wisniewski T. F4-06-03: Insights From Neuropathology And Modulation Of Innate Immunity As A Therapeutic Approach For Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2886  0.332
2018 Prelli F, Drummond E, Pires G, Nayak S, Ueberheide B, Wisniewski T. P1-243: Secernin-1: A Novel Amyloid Plaque And Oligomer Species Associated Protein Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.248  0.355
2018 Angiulli F, Solesio ME, Debure L, Cejudo JR, Wisniewski T, Fossati S. P3-464: Carbonic Anhydrase Inhibitors Ameliorate Neurovascular Dysfunction In A Mouse Model Of Cerebral Amyloid Angiopathy Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1828  0.317
2017 Goñi F, Martá-Ariza M, Peyser D, Herline K, Wisniewski T. Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases. Scientific Reports. 7: 9881. PMID 28852189 DOI: 10.1038/S41598-017-10393-Z  0.368
2017 Liu S, Park S, Allington G, Prelli F, Sun Y, Martá-Ariza M, Scholtzova H, Biswas G, Brown B, Verghese PB, Mehta PD, Kwon YU, Wisniewski T. Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer's Disease Related Pathology and Cognitive Decline. Scientific Reports. 7: 8009. PMID 28808293 DOI: 10.1038/S41598-017-08604-8  0.472
2017 Drummond E, Wisniewski T. The use of localized proteomics to identify the drivers of Alzheimer's disease pathogenesis. Neural Regeneration Research. 12: 912-913. PMID 28761421 DOI: 10.4103/1673-5374.208570  0.375
2017 Rubenstein R, Chang B, Grinkina N, Drummond E, Davies P, Ruditzky M, Sharma D, Wang K, Wisniewski T. Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein. Acta Neuropathologica Communications. 5: 30. PMID 28420443 DOI: 10.1186/S40478-017-0435-7  0.403
2017 Drummond E, Nayak S, Faustin A, Pires G, A Hickman R, Askenazi M, Cohen M, Haldiman T, Kim C, Han X, Shao Y, Safar JG, Ueberheide B, Wisniewski T. Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease. Acta Neuropathologica. PMID 28258398 DOI: 10.1007/S00401-017-1691-0  0.424
2017 Scholtzova H, Do E, Dhakal S, Sun Y, Liu S, Mehta PD, Wisniewski T. Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 936-959. PMID 28123027 DOI: 10.1523/Jneurosci.1967-16.2016  0.465
2017 Liu S, Allington G, Prelli F, Sun Y, Marta-Ariza M, Mehta PD, Scholtzova H, Brown B, Kwon Y, Wisniewski T. TARGETING THE APOLIPOPROTEIN E/AMYLOID β INTERACTION BY CPO_A β 17-21P, A NON-TOXIC AND NON-FIBRILLOGENIC PEPTOID, AMELIORATED A β -RELATED PATHOLOGY AND IMPROVED COGNITIVE DECLINE IN A MOUSE MODEL OF ALZHEIMER’S DISEASE Alzheimers & Dementia. 13: 1506. DOI: 10.1016/J.Jalz.2017.07.619  0.33
2017 Goni F, Herline K, Marta-Ariza M, Boutajangout A, Mehta PD, Prelli F, Wisniewski T. A MONOCLONAL ANTI-OLIGOMER IGM CROSSES THE BBB AND PRODUCES COGNITIVE RESCUE BY LOWERING OLIGOMERIC FORMS OF BOTH TAU AND Aβ IN AN AD ANIMAL MODEL Alzheimers & Dementia. 13: 1487. DOI: 10.1016/J.Jalz.2017.07.568  0.393
2017 Scholtzova H, Nehete PN, Nehete BP, Pei X, Krivoshik SR, Patel AG, Padova A, Andrade AG, Alu MJ, Mehta PD, Williams LE, Wisniewski T. Cerebral Amyloid Angiopathy Treatment Via Innate Immunity Stimulation In Aged Non-Human Primates Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.1263  0.308
2016 Drummond E, Wisniewski T. Alzheimer's disease: experimental models and reality. Acta Neuropathologica. PMID 28025715 DOI: 10.1007/S00401-016-1662-X  0.432
2016 Scholtzova H, Do E, Dhakal S, Sun Y, Liu S, Mehta PD, Wisniewski T. Innate Immunity Stimulation via Toll-like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI mice with Associated Cognitive Benefits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27980116 DOI: 10.1523/JNEUROSCI.1967-16.2016  0.361
2016 Hickman RA, Faustin A, Wisniewski T. Alzheimer Disease and Its Growing Epidemic: Risk Factors, Biomarkers, and the Urgent Need for Therapeutics. Neurologic Clinics. 34: 941-953. PMID 27720002 DOI: 10.1016/J.Ncl.2016.06.009  0.381
2016 Boutajangout A, Noorwali A, Atta H, Wisniewski T. Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease. Current Alzheimer Research. PMID 27719629 DOI: 10.2174/1567205013666161004151416  0.394
2016 Pomara N, Bruno D, Osorio RS, Reichert C, Nierenberg J, Sarreal AS, Hernando RT, Marmar CR, Wisniewski T, Zetterberg H, Blennow K. State-dependent alterations in cerebrospinal fluid Aβ42 levels in cognitively intact elderly with late-life major depression. Neuroreport. PMID 27508979 DOI: 10.1097/Wnr.0000000000000658  0.328
2016 Wisniewski T, Pratico D. Down syndrome dementia and Alzheimer disease: common pathology, common therapeutic targets Neurobiology of Aging. 39. DOI: 10.1016/J.Neurobiolaging.2016.01.106  0.377
2016 Drummond E, Nayak S, Faustin A, Pires G, Hickman R, Safar J, Askenazi M, Cohen M, Haldiman T, Kim C, Ueberheide B, Wisniewski T. Altered Protein Expression In Amyloid Plaques In Rapidly Progressive Alzheimer’S Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.723  0.413
2016 Goni F, Herline K, Marta-Ariza M, Boutajangout A, Mehta PD, Prelli F, Wisniewski T. Disease Modifying Therapy By The Infusion Of An Anti-Conformational Monoclonal Antibody In An Ab And Tau 3Xtg Mouse Model Of Alzheimer’S Disease Alzheimers & Dementia. 12: 360. DOI: 10.1016/J.Jalz.2016.06.667  0.334
2016 Boutajangout A, Lindberg H, Awwad A, Paul A, Baitalmal R, Gudmundsdotter L, Wahlberg E, Hard T, Lofblom J, Stahl S, Wisniewski T. AN AFFIBODY TO MONOMERIC Aβ AS A NOVEL THERAPEUTIC APPROACH FOR ALZHEIMER'S DISEASE PATHOLOGY Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.1708  0.441
2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, ... ... Wisniewski T, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica. PMID 26659578 DOI: 10.1007/S00401-015-1509-X  0.346
2015 Wisniewski T, Drummond E. Developing Therapeutic Vaccines Against Alzheimer's Disease. Expert Review of Vaccines. PMID 26577574 DOI: 10.1586/14760584.2016.1121815  0.458
2015 Drummond ES, Nayak S, Ueberheide B, Wisniewski T. Proteomic analysis of neurons microdissected from formalin-fixed, paraffin-embedded Alzheimer's disease brain tissue. Scientific Reports. 5: 15456. PMID 26487484 DOI: 10.1038/Srep15456  0.317
2015 Chu J, Wisniewski T, Praticò D. GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome. Annals of Neurology. PMID 26448035 DOI: 10.1002/Ana.24540  0.37
2015 Spiegel J, Pirraglia E, Li Y, Tsui W, Glodzik L, Osorio RS, Saint Louis LA, Randall C, Butler T, Xu J, Zinkowski RP, Zetterberg H, Fortea J, Fossati S, Wisniewski T, et al. Greater Specificity for Cerebrospinal Fluid P-tau231 over P-tau181 in the Differentiation of Healthy Controls from Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26444757 DOI: 10.3233/Jad-150167  0.369
2015 Teoh CL, Su D, Sahu S, Yun SW, Drummond E, Prelli F, Lim S, Cho S, Ham S, Wisniewski T, Chang YT. Chemical Fluorescent Probe for Detection of Aβ Oligomers. Journal of the American Chemical Society. PMID 26218347 DOI: 10.1021/Jacs.5B06190  0.411
2015 Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, et al. Clearance systems in the brain-implications for Alzheimer disease. Nature Reviews. Neurology. PMID 26195256 DOI: 10.1038/Nrneurol.2015.119  0.46
2015 Ji Y, Shi Z, Zhang Y, Liu S, Liu S, Yue W, Liu M, Huo YR, Wang J, Wisniewski T. Prevalence of dementia and main subtypes in rural northern China. Dementia and Geriatric Cognitive Disorders. 39: 294-302. PMID 25792116 DOI: 10.1159/000375366  0.332
2015 Wisniewski T, Goñi F. Immunotherapeutic approaches for Alzheimer's disease. Neuron. 85: 1162-76. PMID 25789753 DOI: 10.1016/J.Neuron.2014.12.064  0.466
2015 Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, ... ... Wisniewski T, et al. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathologica. 129: 757-62. PMID 25778618 DOI: 10.1007/S00401-015-1407-2  0.447
2015 Goñi F, Mathiason CK, Yim L, Wong K, Hayes-Klug J, Nalls A, Peyser D, Estevez V, Denkers N, Xu J, Osborn DA, Miller KV, Warren RJ, Brown DR, Chabalgoity JA, ... ... Wisniewski T, et al. Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease. Vaccine. 33: 726-33. PMID 25539804 DOI: 10.1016/J.Vaccine.2014.11.035  0.315
2015 Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, ... ... Wisniewski T, et al. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 700-9. PMID 25510383 DOI: 10.1016/J.Jalz.2014.10.007  0.399
2015 Goni F, Scholtzova H, Marta-Ariza M, Herline K, Sun Y, Pan J, Mehta PD, Wisniewski T. Active vaccination of old Alzheimer’s disease transgenic animals with oligomeric polymerized pbri and cpg odn can reverse preexisting Alzheimer's disease pathology Alzheimers & Dementia. 11: 617. DOI: 10.1016/J.Jalz.2015.06.863  0.39
2015 Goni F, Herline K, Drummond E, Marta-Ariza M, Prelli F, Wisniewski T. Monoclonal antibodies that recognize oligomeric tau and Aβ also recognize pathological structures in parkinson’s disease human brains Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.06.1881  0.396
2014 Yaghmoor F, Noorsaeed A, Alsaggaf S, Aljohani W, Scholtzova H, Boutajangout A, Wisniewski T. The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders. Journal of Alzheimer's Disease & Parkinsonism. 4. PMID 25664220 DOI: 10.4172/2161-0460.1000160  0.377
2014 Sabharwal P, Wisniewski T. Novel immunological approaches for the treatment of Alzheimer's disease. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi. 14: 139-151. PMID 25429302 DOI: 10.3969/J.Issn.1672-6731.2014.03.001  0.469
2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, ... ... Wisniewski T, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/S00401-014-1349-0  0.422
2014 Scholtzova H, Chianchiano P, Pan J, Sun Y, Goñi F, Mehta PD, Wisniewski T. Amyloid β and Tau Alzheimer's disease related pathology is reduced by Toll-like receptor 9 stimulation. Acta Neuropathologica Communications. 2: 101. PMID 25178404 DOI: 10.1186/S40478-014-0101-2  0.473
2014 Boutajangout A, Wisniewski T. Tau-based therapeutic approaches for Alzheimer's disease - a mini-review. Gerontology. 60: 381-5. PMID 24732638 DOI: 10.1159/000358875  0.474
2014 Iulita MF, Do Carmo S, Ower AK, Fortress AM, Aguilar LF, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello AC. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain : a Journal of Neurology. 137: 860-72. PMID 24519975 DOI: 10.1093/Brain/Awt372  0.315
2014 Wisniewski T, Goñi F. Immunotherapy for Alzheimer's disease. Biochemical Pharmacology. 88: 499-507. PMID 24412277 DOI: 10.1016/J.Bcp.2013.12.020  0.474
2014 Liu S, Breitbart A, Sun Y, Mehta PD, Boutajangout A, Scholtzova H, Wisniewski T. Blocking the apolipoprotein E/amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology. Journal of Neurochemistry. 128: 577-91. PMID 24117759 DOI: 10.1111/Jnc.12484  0.485
2014 Boutajangout A, Al-Ahwal M, Habıb H, Wısnıewskı T. Immunotherapy Targeting Tau and Amyloid Aβ Pathology in AD Animal Models Neurobiology of Aging. 35: 721. DOI: 10.1016/J.Neurobiolaging.2013.10.058  0.416
2014 Drummond E, Ueberheide B, Wisniewski T. P1-123: PROTEOMIC ANALYSIS OF ARCHIVED ALZHEIMER'S DISEASE BRAIN TISSUE USING LASER CAPTURE MICRODISSECTION AND LC-MS Alzheimer's & Dementia. 10: P345-P346. DOI: 10.1016/J.Jalz.2014.05.360  0.317
2014 Wisniewski T, Drummond E, Herline K, Sun Y, Goni F. TARGETING THE SHARED PATHOLOGICAL CONFORMERS OF BOTH Aβ AND HYPERPHOSPHYLATED TAU WITH A CONFORMATIONALLY SELECTIVE MONOCLONAL ANTIBODY Alzheimers & Dementia. 10: 237. DOI: 10.1016/J.Jalz.2014.04.348  0.415
2013 Goñi F, Herline K, Peyser D, Wong K, Ji Y, Sun Y, Mehta P, Wisniewski T. Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models. Journal of Neuroinflammation. 10: 150. PMID 24330773 DOI: 10.1186/1742-2094-10-150  0.476
2013 Boutajangout A, Wisniewski T. The innate immune system in Alzheimer's disease. International Journal of Cell Biology. 2013: 576383. PMID 24223593 DOI: 10.1155/2013/576383  0.445
2013 Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB, Strittmatter SM. Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron. 79: 887-902. PMID 24012003 DOI: 10.1016/J.Neuron.2013.06.036  0.331
2013 Wadghiri YZ, Li J, Wang J, Hoang DM, Sun Y, Xu H, Tsui W, Li Y, Boutajangout A, Wang A, de Leon M, Wisniewski T. Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer's disease transgenic mice using magnetic resonance microimaging. Plos One. 8: e57097. PMID 23468919 DOI: 10.1371/Journal.Pone.0057097  0.46
2013 Rubenstein R, Chiu A, Chang B, Wisniewski T. Role of CD40 in prion disease and the immune response to recombinant PrP. Journal of Neuroimmunology. 257: 21-7. PMID 23419881 DOI: 10.1016/J.Jneuroim.2013.01.008  0.314
2013 Wisniewski T, Newman K, Javitt NB. Alzheimer's disease: brain desmosterol levels. Journal of Alzheimer's Disease : Jad. 33: 881-8. PMID 23042211 DOI: 10.3233/Jad-2012-121453  0.364
2013 Goni F, Herline K, Peyser DK, Wong V, Scholtzoa H, Ji Y, Sun Y, Wisniewski T. Immunomodulation targeting pathology-associated protein conformers in 3xTg and TgSwDI mice Alzheimers & Dementia. 9: 847. DOI: 10.1016/J.Jalz.2013.08.015  0.312
2013 Scholtzova H, Williams L, Nehete P, Sabado R, Nehete B, Holmes A, Wisniewski T. P2-410: Innate immunity stimulation via TLR9 in a non-human primate model of sporadic cerebral amyloid angiopathy Alzheimer's & Dementia. 9: P508-P508. DOI: 10.1016/J.Jalz.2013.05.1060  0.308
2013 Goni F, Peyser DK, Herline K, Sun Y, Wisniewski T. Monoclonal antibody therapy targeting the shared pathological conformer of both beta-amyloid and hyperphosphorylated tau Alzheimers & Dementia. 9: 839. DOI: 10.1016/J.Jalz.2013.04.499  0.353
2012 Potter H, Wisniewski T. Apolipoprotein e: essential catalyst of the Alzheimer amyloid cascade. International Journal of Alzheimer's Disease. 2012: 489428. PMID 22844635 DOI: 10.1155/2012/489428  0.42
2012 Um JW, Nygaard HB, Heiss JK, Kostylev MA, Stagi M, Vortmeyer A, Wisniewski T, Gunther EC, Strittmatter SM. Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nature Neuroscience. 15: 1227-35. PMID 22820466 DOI: 10.1038/Nn.3178  0.398
2012 Wisniewski T. Active immunotherapy for Alzheimer's disease. The Lancet. Neurology. 11: 571-2. PMID 22677257 DOI: 10.1016/S1474-4422(12)70136-9  0.458
2012 Wegiel J, Frackowiak J, Mazur-Kolecka B, Schanen NC, Cook EH, Sigman M, Brown WT, Kuchna I, Wegiel J, Nowicki K, Imaki H, Ma SY, Chauhan A, Chauhan V, Miller DL, ... ... Wisniewski T, et al. Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders. Plos One. 7: e35414. PMID 22567102 DOI: 10.1371/Journal.Pone.0035414  0.384
2012 Wadghiri YZ, Hoang DM, Wisniewski T, Sigurdsson EM. In vivo magnetic resonance imaging of amyloid-β plaques in mice. Methods in Molecular Biology (Clifton, N.J.). 849: 435-51. PMID 22528108 DOI: 10.1007/978-1-61779-551-0_30  0.363
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... ... Wisniewski T, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/Nen.0B013E31825018F7  0.404
2012 Wisniewski T, Goñi F. Could immunomodulation be used to prevent prion diseases? Expert Review of Anti-Infective Therapy. 10: 307-17. PMID 22397565 DOI: 10.1586/Eri.11.177  0.343
2012 Leal MC, Surace EI, Holgado MP, Ferrari CC, Tarelli R, Pitossi F, Wisniewski T, Castaño EM, Morelli L. Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism. Biochimica Et Biophysica Acta. 1823: 227-35. PMID 22036964 DOI: 10.1016/J.Bbamcr.2011.09.014  0.371
2012 Ge Y, Zhou Y, Wisniewski T, Li Y, Newman K, Leon MD. 7 Tesla MR susceptibility-contrast microscopy imaging of amyloid pathology and the hippocampus in Alzheimer's disease Alzheimers & Dementia. 8: 699. DOI: 10.1016/J.Jalz.2012.05.1884  0.41
2012 Goni F, Wong K, Scholtzova H, Sun Y, Pan J, Li J, Ji Y, Wisniewski T. Active immunomodulation targeting abnormal conformation for the treatment of multiple neurodegenerative diseases Alzheimers & Dementia. 8: 625. DOI: 10.1016/J.Jalz.2012.05.1665  0.313
2012 Scholtzova H, Goni F, Pan J, Sun Y, Li J, Mehta P, Wisniewski T. Innate immunity stimulation as a novel therapeutic approach in Alzheimer's disease Alzheimers & Dementia. 8: 392. DOI: 10.1016/J.Jalz.2012.05.1078  0.445
2011 Chung E, Prelli F, Dealler S, Lee WS, Chang YT, Wisniewski T. Styryl-based and tricyclic compounds as potential anti-prion agents. Plos One. 6: e24844. PMID 21931860 DOI: 10.1371/Journal.Pone.0024844  0.6
2011 Yang J, Wadghiri YZ, Hoang DM, Tsui W, Sun Y, Chung E, Li Y, Wang A, de Leon M, Wisniewski T. Detection of amyloid plaques targeted by USPIO-Aβ1-42 in Alzheimer's disease transgenic mice using magnetic resonance microimaging. Neuroimage. 55: 1600-9. PMID 21255656 DOI: 10.1016/J.Neuroimage.2011.01.023  0.658
2011 Yang J, Ji Y, Mehta P, Bates KA, Sun Y, Wisniewski T. Blocking the apolipoprotein E/amyloid-β interaction reduces fibrillar vascular amyloid deposition and cerebral microhemorrhages in TgSwDI mice. Journal of Alzheimer's Disease : Jad. 24: 269-85. PMID 21239853 DOI: 10.3233/Jad-2011-101401  0.476
2011 Wegiel J, Kaczmarski W, Barua M, Kuchna I, Nowicki K, Wang KC, Wegiel J, Yang SM, Frackowiak J, Mazur-Kolecka B, Silverman WP, Reisberg B, Monteiro I, de Leon M, Wisniewski T, et al. Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. Journal of Neuropathology and Experimental Neurology. 70: 36-50. PMID 21157379 DOI: 10.1097/Nen.0B013E318202Bfa1  0.371
2011 Goni F, Scholtzova H, Wong K, Sun Y, Pan J, Li J, Ji Y, Wisniewski T. Conformation directed immunomodulation targeting amyloid plaques, CAA and neurofibrillary tangle pathology in model mice Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.09.143  0.409
2011 Scholtzova H, Goni F, Sun Y, Hatos L, Pan J, Kascsak R, Mehta P, Spinner D, Wisniewski T. Induction of TLR9 signaling in 3xTg-AD mice Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1912  0.336
2010 Wisniewski T, Goñi F. Immunomodulation for prion and prion-related diseases. Expert Review of Vaccines. 9: 1441-52. PMID 21105779 DOI: 10.1586/Erv.10.131  0.379
2010 Goñi F, Prelli F, Ji Y, Scholtzova H, Yang J, Sun Y, Liang FX, Kascsak R, Kascsak R, Mehta P, Wisniewski T. Immunomodulation targeting abnormal protein conformation reduces pathology in a mouse model of Alzheimer's disease. Plos One. 5: e13391. PMID 20967130 DOI: 10.1371/Journal.Pone.0013391  0.496
2010 Chung E, Ji Y, Sun Y, Kascsak RJ, Kascsak RB, Mehta PD, Strittmatter SM, Wisniewski T. Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. Bmc Neuroscience. 11: 130. PMID 20946660 DOI: 10.1186/1471-2202-11-130  0.638
2010 Wisniewski T, Sigurdsson EM. Murine models of Alzheimer's disease and their use in developing immunotherapies. Biochimica Et Biophysica Acta. 1802: 847-59. PMID 20471477 DOI: 10.1016/J.Bbadis.2010.05.004  0.477
2010 Wisniewski T, Boutajangout A. Vaccination as a therapeutic approach to Alzheimer's disease. The Mount Sinai Journal of Medicine, New York. 77: 17-31. PMID 20101719 DOI: 10.1002/Msj.20156  0.472
2010 Wisniewski T, Boutajangout A. Immunotherapeutic approaches for Alzheimer's disease in transgenic mouse models. Brain Structure & Function. 214: 201-18. PMID 20012091 DOI: 10.1007/S00429-009-0236-2  0.474
2010 Yang J, Scholtzova H, Ji Y, Sun Y, Wisniewski T. Blocking Aβ/Chaperone Interactions to Prevent CAA Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.08.078  0.336
2010 Goldstein LE, Moir RD, Mocofanescu A, Fu L, Lu S, Burton MA, Xu W, Ericsson M, Rogers J, Chadwick O, Sadowski M, Wisniewski T, Klunk WE, Mathis CA, Clark JI, et al. P4-011: In vivo Detection of Early Alzheimer's Disease-Linked Aβ Peptide Accumulation in the Lens by Non-Invasive Quasi-Elastic Light Scattering Alzheimer's & Dementia. 6: e23-e23. DOI: 10.1016/J.Jalz.2010.08.071  0.374
2010 Chung E, Prelli F, Yeoun D, Chang Y, Wisniewski T. Treatment of prion infection in vitro and in vivo Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.424  0.527
2010 Goni F, Prelli F, Kascsak R, Kascsak R, Wisniewski T. Development of conformational monoclonal antibodies that detects multiple amyloid proteins Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.2006  0.324
2010 Wisniewski T, Chung E, Ji Y, Sun Y, Kascsak R, Kascsak R, Strittmatter SM. Anti-PrPC monoclonal antibody infusion as a novel treatment for Aß oligomer cognitive deficits Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.2004  0.638
2010 Scholtzova H, Ji Y, Goni F, Sun Y, Kascsak R, Mehta PD, Spinner DS, Wisniewski T. Stimulation of innate immunity via Toll-like receptor 9 mitigates Alzheimer pathology Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1913  0.306
2010 Yang J, Hoang MD, Wadghiri YZ, Wisniewski T. Detection of amyloid plaques in Alzheimer's transgenic mice using contrast-enhanced magentic resonance microimaging Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1406  0.406
2009 Boutajangout A, Goni F, Knudsen E, Schreiber F, Asuni A, Quartermain D, Frangione B, Chabalgoity A, Wisniewski T, Sigurdsson EM. Diminished amyloid-beta burden in Tg2576 mice following a prophylactic oral immunization with a salmonella-based amyloid-beta derivative vaccine. Journal of Alzheimer's Disease : Jad. 18: 961-72. PMID 19749432 DOI: 10.3233/Jad-2009-1204  0.434
2009 Sadowski MJ, Pankiewicz J, Prelli F, Scholtzova H, Spinner DS, Kascsak RB, Kascsak RJ, Wisniewski T. Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo. Neurobiology of Disease. 34: 267-78. PMID 19385058 DOI: 10.1016/J.Nbd.2009.01.013  0.339
2009 Wisniewski T. AD vaccines: conclusions and future directions. Cns & Neurological Disorders Drug Targets. 8: 160-6. PMID 19355935 DOI: 10.2174/187152709787847289  0.435
2009 Scholtzova H, Kascsak RJ, Bates KA, Boutajangout A, Kerr DJ, Meeker HC, Mehta PD, Spinner DS, Wisniewski T. Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1846-54. PMID 19211891 DOI: 10.1523/Jneurosci.5715-08.2009  0.463
2009 Trouche SG, Asuni A, Rouland S, Wisniewski T, Frangione B, Verdier JM, Sigurdsson EM, Mestre-Francés N. Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives. Vaccine. 27: 957-64. PMID 19114076 DOI: 10.1016/J.Vaccine.2008.12.012  0.381
2009 Zhan J, Brys M, Glodzik L, Tsui W, Javier E, Wegiel J, Kuchna I, Pirraglia E, Li Y, Mosconi L, Saint Louis LA, Switalski R, De Santi S, Kim BC, Wisniewski T, et al. An entorhinal cortex sulcal pattern is associated with Alzheimer's disease. Human Brain Mapping. 30: 874-82. PMID 18381771 DOI: 10.1002/Hbm.20549  0.365
2009 Goni F, Estevez V, Yim L, Sun Y, Chung E, Carp R, Meeker C, Rubenstein R, Chabalgoity A, Wisniewski T. Mucosal vaccination of elk-PrP transgenic mice to prevent prion transmission via an oral route Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.07.138  0.558
2009 Scholtzova H, Kascsak RJ, Bates KA, Boutajangout A, Kerr DJ, Meeker HC, Mehta PD, Spinner DS, Wisniewski T. Toll-like receptor 9 ligand CpG ODN as a new highly effective agent for prevention and/or treatment of Alzheimer's disease Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.05.467  0.325
2009 Wisniewski T, Prelli F, Scholtzova H, Chung E, Mehta PD, Kascsak R, Kascsak R, Goni F. Immunotherapy targeting abnormal protein conformation Alzheimers & Dementia. 5: 113. DOI: 10.1016/J.Jalz.2009.05.354  0.537
2009 Boutajangout A, Frangione B, Wisniewski T, Brion J, Sigurdsson EM. P4-049: Influence of presenilin mutation on tau pathology in a novel Alzheimer's disease mouse model Alzheimer's & Dementia. 5: P445-P446. DOI: 10.1016/J.Jalz.2009.04.919  0.404
2008 Wisniewski T, Sadowski M. Preventing beta-amyloid fibrillization and deposition: beta-sheet breakers and pathological chaperone inhibitors. Bmc Neuroscience. 9: S5. PMID 19090993 DOI: 10.1186/1471-2202-9-S2-S5  0.466
2008 Cercy SP, Sadowski MJ, Wisniewski T. Prominent neuroleptic sensitivity in a case of early-onset Alzheimer disease due to presenilin-1 G206A mutation. Cognitive and Behavioral Neurology : Official Journal of the Society For Behavioral and Cognitive Neurology. 21: 190-5. PMID 18797263 DOI: 10.1097/Wnn.0B013E31817D74Bf  0.328
2008 Spinner DS, Cho IS, Park SY, Kim JI, Meeker HC, Ye X, Lafauci G, Kerr DJ, Flory MJ, Kim BS, Kascsak RB, Wisniewski T, Levis WR, Schuller-Levis GB, Carp RI, et al. Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice. Journal of Virology. 82: 10701-8. PMID 18715916 DOI: 10.1128/Jvi.00522-08  0.311
2008 Wegiel J, Dowjat K, Kaczmarski W, Kuchna I, Nowicki K, Frackowiak J, Mazur Kolecka B, Wegiel J, Silverman WP, Reisberg B, Deleon M, Wisniewski T, Gong CX, Liu F, Adayev T, et al. The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome. Acta Neuropathologica. 116: 391-407. PMID 18696092 DOI: 10.1007/S00401-008-0419-6  0.372
2008 Wisniewski T, Konietzko U. Amyloid-beta immunisation for Alzheimer's disease. The Lancet. Neurology. 7: 805-11. PMID 18667360 DOI: 10.1016/S1474-4422(08)70170-4  0.444
2008 Scholtzova H, Wadghiri YZ, Douadi M, Sigurdsson EM, Li YS, Quartermain D, Banerjee P, Wisniewski T. Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging. Journal of Neuroscience Research. 86: 2784-91. PMID 18615702 DOI: 10.1002/Jnr.21713  0.441
2008 Gambetti P, Dong Z, Yuan J, Xiao X, Zheng M, Alshekhlee A, Castellani R, Cohen M, Barria MA, Gonzalez-Romero D, Belay ED, Schonberger LB, Marder K, Harris C, Burke JR, ... ... Wisniewski T, et al. A novel human disease with abnormal prion protein sensitive to protease. Annals of Neurology. 63: 697-708. PMID 18571782 DOI: 10.1002/Ana.21420  0.364
2008 Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4231-7. PMID 18417702 DOI: 10.1523/Jneurosci.5161-07.2008  0.415
2008 Goñi F, Prelli F, Schreiber F, Scholtzova H, Chung E, Kascsak R, Brown DR, Sigurdsson EM, Chabalgoity JA, Wisniewski T. High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice. Neuroscience. 153: 679-86. PMID 18407424 DOI: 10.1016/J.Neuroscience.2008.02.051  0.597
2008 Firuzi O, Zhuo J, Chinnici CM, Wisniewski T, Praticò D. 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1169-78. PMID 17998412 DOI: 10.1096/Fj.07-9131.Com  0.438
2008 Sigurdsson EM, Wadghiri YZ, Mosconi L, Blind JA, Knudsen E, Asuni A, Scholtzova H, Tsui WH, Li Y, Sadowski M, Turnbull DH, de Leon MJ, Wisniewski T. A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice. Neurobiology of Aging. 29: 836-47. PMID 17291630 DOI: 10.1016/J.Neurobiolaging.2006.12.018  0.405
2008 Moncaster JA, Moir RD, Mocofanescu AG, Burton MA, Ghosh J, Ericsson M, Rogers JT, Klunk WE, Mathis CA, Sadowski M, Wisniewski T, Clark JI, Tanzi RE, Goldstein LE. P1-379: In vivo detection of Alzheimer's disease–linked Aβ peptide accumulation in the lens Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.961  0.384
2008 Trouche SG, Asuni A, Boutajangout A, Frangione B, Wisniewski T, Rouland S, Verdier J, Sigurdsson EM, Mestre-Frances N. P1-021: Neuropathological evaluation of the nonhuman primate microcebus murinus immunized with K6Aβ1-30, an Aβ derivative peptide Alzheimer's & Dementia. 4: T211-T211. DOI: 10.1016/J.Jalz.2008.05.606  0.326
2008 Boutajangout A, Frangione B, Brion J, Wisniewski T, Sigurdsson EM. O4-01-05: Presenilin 1 mutation promotes Tau phosphorylation and aggregation in a novel Alzheimer's disease mouse model Alzheimer's & Dementia. 4: T185-T185. DOI: 10.1016/J.Jalz.2008.05.504  0.403
2008 Scholtzova H, Kascsak RJ, Kerr DJ, Marchi EJ, Boutajangout A, Chung E, Quartermain D, Spinner DS, Wisniewski T. P2-405: Induction of toll-like receptor 9 signaling as a method for preventing or ameliorating Alzheimer's disease Alzheimer's & Dementia. 4: T492-T492. DOI: 10.1016/J.Jalz.2008.05.1484  0.547
2008 Sadowski MJ, Pulyk R, Poon SY, Pankiewicz JE, Scholtzova H, Quartermain D, Wisniewski T. P1-441: Increased parenchymal and vascular Aβ deposition in Alzheimer's disease transgenic mice with chronic hyperglycemia Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1023  0.423
2007 Li Q, Min J, Ahn YH, Namm J, Kim EM, Lui R, Kim HY, Ji Y, Wu H, Wisniewski T, Chang YT. Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques. Chembiochem : a European Journal of Chemical Biology. 8: 1679-87. PMID 17705341 DOI: 10.1002/Cbic.200700154  0.404
2007 Webb S, Lekishvili T, Loeschner C, Sellarajah S, Prelli F, Wisniewski T, Gilbert IH, Brown DR. Mechanistic insights into the cure of prion disease by novel antiprion compounds. Journal of Virology. 81: 10729-41. PMID 17652397 DOI: 10.1128/Jvi.01075-07  0.344
2007 Sadowski M, Wisniewski T. Disease modifying approaches for Alzheimer's pathology. Current Pharmaceutical Design. 13: 1943-54. PMID 17627527 DOI: 10.2174/138161207781039788  0.476
2007 Wisniewski T, Sigurdsson EM. Therapeutic approaches for prion and Alzheimer's diseases. The Febs Journal. 274: 3784-98. PMID 17617224 DOI: 10.1111/J.1742-4658.2007.05919.X  0.38
2007 Spinner DS, Kascsak RB, Lafauci G, Meeker HC, Ye X, Flory MJ, Kim JI, Schuller-Levis GB, Levis WR, Wisniewski T, Carp RI, Kascsak RJ. CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils. Journal of Leukocyte Biology. 81: 1374-85. PMID 17379700 DOI: 10.1189/Jlb.1106665  0.314
2007 Wegiel J, Kuchna I, Nowicki K, Frackowiak J, Mazur-Kolecka B, Imaki H, Wegiel J, Mehta PD, Silverman WP, Reisberg B, Deleon M, Wisniewski T, Pirttilla T, Frey H, Lehtimäki T, et al. Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration. Acta Neuropathologica. 113: 389-402. PMID 17237937 DOI: 10.1007/S00401-006-0191-4  0.381
2007 Chang B, Cheng X, Yin S, Pan T, Zhang H, Wong P, Kang SC, Xiao F, Yan H, Li C, Wolfe LL, Miller MW, Wisniewski T, Greene MI, Sy MS. Test for detection of disease-associated prion aggregate in the blood of infected but asymptomatic animals. Clinical and Vaccine Immunology : Cvi. 14: 36-43. PMID 17079434 DOI: 10.1128/Cvi.00341-06  0.354
2007 Banerjee P, Tanila H, Wisniewski T, Gupta S, LaFerla F, Lahiri DK. P-188: Memantine lowers amyloid beta levels in neuronal cells and transgenic mouse models of Alzheimer's disease Alzheimer's & Dementia. 3: S158-S158. DOI: 10.1016/J.Jalz.2007.04.151  0.408
2007 Moncaster J, Moir RD, Fu L, Mocofanescu A, Lu S, Xu W, Chadwick O, Rogers JT, Sadowski M, Wisniewski T, Klunk WE, Mathis CA, Clark JI, Tanzi RE, Goldstein LE. O2-03-05: Early detection of Alzheimer's disease-linked aβ peptide accumulation in the lens by non-invasive quasi-elastic light scattering Alzheimer's & Dementia. 3: S190-S190. DOI: 10.1016/J.Jalz.2007.04.030  0.353
2006 Sadowski MJ, Pankiewicz J, Scholtzova H, Mehta PD, Prelli F, Quartermain D, Wisniewski T. Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 18787-92. PMID 17116874 DOI: 10.1073/Pnas.0604011103  0.439
2006 Asuni AA, Boutajangout A, Scholtzova H, Knudsen E, Li YS, Quartermain D, Frangione B, Wisniewski T, Sigurdsson EM. Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages. The European Journal of Neuroscience. 24: 2530-42. PMID 17100841 DOI: 10.1111/J.1460-9568.2006.05149.X  0.425
2006 Leal MC, Dorfman VB, Gamba AF, Frangione B, Wisniewski T, Castaño EM, Sigurdsson EM, Morelli L. Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology. Journal of Neuropathology and Experimental Neurology. 65: 976-87. PMID 17021402 DOI: 10.1097/01.Jnen.0000235853.70092.Ba  0.417
2006 Pankiewicz J, Prelli F, Sy MS, Kascsak RJ, Kascsak RB, Spinner DS, Carp RI, Meeker HC, Sadowski M, Wisniewski T. Clearance and prevention of prion infection in cell culture by anti-PrP antibodies. The European Journal of Neuroscience. 23: 2635-47. PMID 16817866 DOI: 10.1111/J.1460-9568.2006.04805.X  0.305
2006 Scholtzova H, Wadghiri YZ, Sigurdsson EM, Douadi M, Li Y, Quartermain D, Banerjee PK, Wisniewski T. P.5.b.003 Assessing the effects of memantine in APP/PS1 transgenic mice by behavioural studies and ex vivo imaging of amyloid plaques using gadolinium labelled amyloid β peptides and μMRI European Neuropsychopharmacology. 16. DOI: 10.1016/S0924-977X(06)70645-9  0.389
2006 Wisniewski T, Scholtzova H, Wadghiri YZ, Sigurdsson EM, Douadi M, Li Y, Quartermain D, Banerjee PK. P1-104: Assessing the effects of memantine in APP/PS1 transgenic mice by behavioral studies and ex vivo imaging of amyloid plaques using gadolinium labeled amyloid β peptides and micromri Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.480  0.39
2006 Boutajangout A, Asuni AA, Scholtzova H, Knudsen E, Li Y, Quartermain D, Frangione B, Wisniewski T, Sigurdsson EM. P4-316: Aβ derivative vaccine does not cause brain microhemorrhages in Tg2576 mice and its effectiveness is age-dependent Alzheimer's & Dementia. 2: S609-S610. DOI: 10.1016/J.Jalz.2006.05.2057  0.344
2006 Trouche S, Asuni A, Wisniewski T, Frangione B, Sigurdsson E, Verdier J, Mestre-Frances N. P4-290: Immunization with Aβ derivatives in Microcebus murinus : A primate lemurian model of Alzheimer's disease Alzheimer's & Dementia. 2: S602-S602. DOI: 10.1016/J.Jalz.2006.05.2029  0.421
2006 Prelli F, Pankiewicz J, Moncaster J, Klunk W, Carp R, Meeker H, Sadowski M, Goldstein LE, Wisniewski T. P4-123: PrPSc Aggregates in the ocular lens of symptomatic and pre-symptomatic prion infected mice Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1862  0.315
2006 Leal MC, Dorfman VB, Fernandez Gamba AC, Frangione B, Wisniewski T, Castaño EM, Sigurdsson EM, Morelli L. P4-075: Fibrillar Aβ triggers insulin degrading enzyme (IDE) over-expression by glial cells in old Tg2576 mice Alzheimer's & Dementia. 2: S535-S536. DOI: 10.1016/J.Jalz.2006.05.1813  0.304
2006 Wu H, Ji Y, Scholtzova H, Li Q, Sadowski M, Gan W, Chang Y, Wisniewski T. AbstractPoster presentation: Monday posterP2-325: In VIVO labeling of amyloid β plaques in AD model mice using blood-brain barrier permeable styryl dyes Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1165  0.406
2005 Pan T, Chang B, Wong P, Li C, Li R, Kang SC, Robinson JD, Thompsett AR, Tein P, Yin S, Barnard G, McConnell I, Brown DR, Wisniewski T, Sy MS. An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates. Journal of Virology. 79: 12355-64. PMID 16160162 DOI: 10.1128/Jvi.79.19.12355-12364.2005  0.364
2005 Wadghiri YZ, Sigurdsson EM, Wisniewski T, Turnbull DH. Magnetic resonance imaging of amyloid plaques in transgenic mice. Methods in Molecular Biology (Clifton, N.J.). 299: 365-79. PMID 15980617 DOI: 10.1385/1-59259-874-9:365  0.354
2005 Goñi F, Knudsen E, Schreiber F, Scholtzova H, Pankiewicz J, Carp R, Meeker HC, Rubenstein R, Brown DR, Sy MS, Chabalgoity JA, Sigurdsson EM, Wisniewski T. Mucosal vaccination delays or prevents prion infection via an oral route. Neuroscience. 133: 413-21. PMID 15878645 DOI: 10.1016/J.Neuroscience.2005.02.031  0.317
2005 Sassoon J, Sadowski M, Wisniewski T, Brown DR. Therapeutics and prion disease: can immunisation or drugs be effective? Mini Reviews in Medicinal Chemistry. 5: 361-6. PMID 15853626 DOI: 10.2174/1389557053544065  0.324
2005 Wisniewski T, Frangione B. Immunological and anti-chaperone therapeutic approaches for Alzheimer disease. Brain Pathology (Zurich, Switzerland). 15: 72-7. PMID 15779239 DOI: 10.1111/J.1750-3639.2005.Tb00102.X  0.452
2005 Wisniewski T. Is amyloid-β-peptide immunization clinically effective in patients with Alzheimer's disease? Nature Reviews Neurology. 1: 84-85. DOI: 10.1038/Ncpneuro0019  0.394
2005 Sigurdsson E, Wadghiri Y, Knudsen E, Asuni A, Sadowski M, Turnbull D, Wisniewski T. [O1-03-05]: In vivo detection of amyloid plaques in AD transgenic mice using gadolinium labeled ligands by MRI Alzheimer's & Dementia. 1: S84-S84. DOI: 10.1016/J.Jalz.2005.06.296  0.368
2005 Sadowski M, Pankiewicz J, Scholtzova H, Wen P, Mehta P, Wisniewski T. Blocking the apolipoprotein E/amyloid-B interaction reduces amyloid-B load in AD transgenic mice Alzheimers & Dementia. 1. DOI: 10.1016/J.Jalz.2005.06.243  0.375
2004 Ghiso J, Wisniewski T. An animal model of vascular amyloidosis. Nature Neuroscience. 7: 902-4. PMID 15332087 DOI: 10.1038/Nn0904-902  0.431
2004 Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. The American Journal of Pathology. 165: 937-48. PMID 15331417 DOI: 10.1016/S0002-9440(10)63355-X  0.434
2004 Sadowski M, Pankiewicz J, Scholtzova H, Tsai J, Li Y, Carp RI, Meeker HC, Gambetti P, Debnath M, Mathis CA, Shao L, Gan WB, Klunk WE, Wisniewski T. Targeting prion amyloid deposits in vivo. Journal of Neuropathology and Experimental Neurology. 63: 775-84. PMID 15290902 DOI: 10.1093/Jnen/63.7.775  0.436
2004 Sigurdsson EM, Knudsen E, Asuni A, Fitzer-Attas C, Sage D, Quartermain D, Goni F, Frangione B, Wisniewski T. An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6277-82. PMID 15254082 DOI: 10.1523/Jneurosci.1344-04.2004  0.445
2004 Sadowski M, Pankiewicz J, Scholtzova H, Ji Y, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, Wisniewski T. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology. 63: 418-28. PMID 15198121 DOI: 10.1093/Jnen/63.5.418  0.371
2004 Sadowski M, Wisniewski T. Vaccines for conformational disorders. Expert Review of Vaccines. 3: 279-90. PMID 15176944 DOI: 10.1586/14760584.3.3.279  0.391
2004 Sadowski M, Pankiewicz J, Scholtzova H, Li YS, Quartermain D, Duff K, Wisniewski T. Links between the pathology of Alzheimer's disease and vascular dementia. Neurochemical Research. 29: 1257-66. PMID 15176482 DOI: 10.1023/B:Nere.0000023612.66691.E6  0.437
2004 Kang SC, Brown DR, Whiteman M, Li R, Pan T, Perry G, Wisniewski T, Sy MS, Wong BS. Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice. The Journal of Pathology. 203: 603-8. PMID 15095484 DOI: 10.1002/Path.1555  0.324
2004 Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 51: 794-8. PMID 15065253 DOI: 10.1002/Mrm.20038  0.453
2004 Dowjat WK, Kuchna I, Wisniewski T, Wegiel J. A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations. Journal of Alzheimer's Disease : Jad. 6: 31-43. PMID 15004326 DOI: 10.3233/Jad-2004-6105  0.321
2004 Wisniewski T, Pankiewicz J, Scholtzova H, Schmidt SD, Mathews PM, Sigurdsson EM, Sadowski M. P4-381 Reduction of β-amyloid load in Alzheimer's disease transgenic mice by competitive blocking of β-amyloid binding to apolipoprotein E Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81939-0  0.406
2004 Asuni AA, Knudsen E, Frangione B, Wisniewski T, Sigurdsson EM. P4-375 Antibody mediated modulation of Aβ induced neurotoxicity in cell culture Neurobiology of Aging. 25: S581-S582. DOI: 10.1016/S0197-4580(04)81933-X  0.309
2004 Sigurdsson EM, Knudsen E, Asuni A, Sage D, Goni F, Quartermain D, Frangione B, Wisniewski T. P4-357 Modest immune response elicited by Aβ derivatives in TG2576 mice improves cognition Neurobiology of Aging. 25: S576. DOI: 10.1016/S0197-4580(04)81915-8  0.331
2004 Kuchna I, Nowicki K, Imaki H, Wang K, Mehta PD, Silverman WP, Reisberg B, Leon Md, Wisniewski T, Pirttila T, Frey H, Lehtimaki T, Kivimaki T, Visser FE, Kamphorst W, et al. P3-182 Intraneuronal amyloid beta immunoreactivity is not a predictor of fibrillar plaque formation or neurofibrillary degeneration Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81334-4  0.367
2004 Sadowski M, Pankiewicz J, Scholtzova H, Tsai J, Carp RI, Meeker HC, Debnath M, Mathis CA, Shao L, Klunk WE, Gan W, Wisniewski T. P2-186 In vivo imaging of prion amyloid deposits Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80932-1  0.339
2004 Scholtzova H, Pankiewicz J, Sadowski M, Quartermain D, Jensen CH, Duff K, Nixon RA, Helpern JH, Gruen RJ, Wisniewski T. P2-007 Age-associated behavioral, metabolic, and structural changes in wild-type littermates of Alzheimer's transgenic mice Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80755-3  0.333
2004 Sigurdsson EM, Wadghiri YZ, Blind JA, Knudsen E, Asuni AA, Sadowski M, Turnbull DH, Wisniewski T. O3-03-03 In vivo magnetic resonance imaging of amyloid plaques in mice with a non-toxic Aβ derivative Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80193-3  0.352
2004 Wisniewski T, Pankiewicz J, Scholtzova H, Fernando G, Chabalgoity JA, Ji Y, Wadghiri YZ, Gan W, Tang CY, Turnbull DH, Mathis CA, Kascsak R, Klunk WE, Carp RI, Frangione B, et al. S2-04-04 Imaging and therapeutic approaches for β-sheet structures in prion and Alzheimer's diseases Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80100-3  0.354
2003 Ji Y, Gong Y, Gan W, Beach T, Holtzman DM, Wisniewski T. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience. 122: 305-15. PMID 14614898 DOI: 10.1016/J.Neuroscience.2003.08.007  0.372
2003 Sigurdsson EM, Brown DR, Alim MA, Scholtzova H, Carp R, Meeker HC, Prelli F, Frangione B, Wisniewski T. Copper chelation delays the onset of prion disease. The Journal of Biological Chemistry. 278: 46199-202. PMID 14519758 DOI: 10.1074/Jbc.C300303200  0.316
2003 Wadghiri YZ, Sigurdsson EM, Sadowski M, Elliott JI, Li Y, Scholtzova H, Tang CY, Aguinaldo G, Pappolla M, Duff K, Wisniewski T, Turnbull DH. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 50: 293-302. PMID 12876705 DOI: 10.1002/Mrm.10529  0.427
2003 Sigurdsson EM, Sy MS, Li R, Scholtzova H, Kascsak RJ, Kascsak R, Carp R, Meeker HC, Frangione B, Wisniewski T. Anti-prion antibodies for prophylaxis following prion exposure in mice. Neuroscience Letters. 336: 185-7. PMID 12505623 DOI: 10.1016/S0304-3940(02)01192-8  0.362
2002 Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascular Pharmacology. 38: 303-13. PMID 12529925 DOI: 10.1016/S1537-1891(02)00198-2  0.314
2002 Poduslo JF, Wengenack TM, Curran GL, Wisniewski T, Sigurdsson EM, Macura SI, Borowski BJ, Jack CR. Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging. Neurobiology of Disease. 11: 315-29. PMID 12505424 DOI: 10.1006/Nbdi.2002.0550  0.38
2002 Sigurdsson EM, Wisniewski T, Frangione B. A safer vaccine for Alzheimer's disease? Neurobiology of Aging. 23: 1001-8. PMID 12470795 DOI: 10.1016/S0197-4580(02)00124-0  0.45
2002 de Leon MJ, Segal S, Tarshish CY, DeSanti S, Zinkowski R, Mehta PD, Convit A, Caraos C, Rusinek H, Tsui W, Saint Louis LA, DeBernardis J, Kerkman D, Qadri F, Gary A, ... ... Wisniewski T, et al. Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment. Neuroscience Letters. 333: 183-6. PMID 12429378 DOI: 10.1016/S0304-3940(02)01038-8  0.414
2002 Sigurdsson EM, Wisniewski T, Frangione B. Infectivity of amyloid diseases. Trends in Molecular Medicine. 8: 411-3. PMID 12223307 DOI: 10.1016/S1471-4914(02)02403-6  0.443
2002 Wisniewski T, Brown DR, Sigurdsson EM. Therapeutics in Alzheimer's and prion diseases. Biochemical Society Transactions. 30: 574-8. PMID 12196140 DOI: 10.1042/Bst0300574  0.392
2002 Wisniewski T, Sigurdsson EM. Immunization treatment approaches in Alzheimer's and prion diseases. Current Neurology and Neuroscience Reports. 2: 400-4. PMID 12169219 DOI: 10.1007/S11910-002-0065-7  0.444
2002 Sigurdsson EM, Brown DR, Daniels M, Kascsak RJ, Kascsak R, Carp R, Meeker HC, Frangione B, Wisniewski T. Immunization delays the onset of prion disease in mice. The American Journal of Pathology. 161: 13-7. PMID 12107084 DOI: 10.1016/S0002-9440(10)64151-X  0.37
2002 Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiology of Disease. 10: 8-19. PMID 12079399 DOI: 10.1006/Nbdi.2002.0490  0.31
2002 Wegiel J, Kuchna I, Wisniewski T, de Leon MJ, Reisberg B, Pirttila T, Kivimaki T, Lehtimaki T. Vascular fibrosis and calcification in the hippocampus in aging, Alzheimer disease, and Down syndrome. Acta Neuropathologica. 103: 333-43. PMID 11904752 DOI: 10.1007/S00401-001-0471-Y  0.348
2002 Sigurdsson EM, Frangione B, Wisniewski T. Immunization for Alzheimer's disease Drug Development Research. 56: 135-142. DOI: 10.1002/Ddr.10068  0.471
2001 Wisniewski T, Sigurdsson EM, Aucouturier P, Frangione B. Conformation as therapeutic target in the prionoses and other neurodegenerative conditions. Methods in Molecular Medicine. 59: 223-36. PMID 21374507 DOI: 10.1385/1-59259-134-5:223  0.437
2001 Ji Y, Permanne B, Sigurdsson EM, Holtzman DM, Wisniewski T. Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice. Journal of Alzheimer's Disease : Jad. 3: 23-30. PMID 12214069 DOI: 10.3233/Jad-2001-3105  0.427
2001 Poeggeler B, Miravalle L, Zagorski MG, Wisniewski T, Chyan YJ, Zhang Y, Shao H, Bryant-Thomas T, Vidal R, Frangione B, Ghiso J, Pappolla MA. Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide. Biochemistry. 40: 14995-5001. PMID 11732920 DOI: 10.1021/Bi0114269  0.455
2001 Wegiel J, Bobinski M, Tarnawski M, Dziewiatkowski J, Popovitch E, Miller DC, Wisniewski T, Golomb J, de Leon MJ, Reisberg B. Fibrillar amyloid-beta affects neurofibrillary changes but only in neurons already involved in neurofibrillary degeneration. Acta Neuropathologica. 101: 585-90. PMID 11515787 DOI: 10.1007/S004010000334  0.389
2001 Sigurdsson EM, Scholtzova H, Mehta PD, Frangione B, Wisniewski T. Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. The American Journal of Pathology. 159: 439-47. PMID 11485902 DOI: 10.1016/S0002-9440(10)61715-4  0.441
2001 Dowjat WK, Wisniewski H, Wisniewski T. Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments. Neuroscience. 103: 1-8. PMID 11311782 DOI: 10.1016/S0306-4522(00)00550-9  0.37
2000 Golabek AA, Kida E, Walus M, Perez C, Wisniewski T, Soto C. Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E. Biophysical Journal. 79: 1008-15. PMID 10920030 DOI: 10.1016/S0006-3495(00)76354-5  0.305
2000 Aucouturier P, Carp RI, Carnaud C, Wisniewski T. Prion diseases and the immune system. Clinical Immunology (Orlando, Fla.). 96: 79-85. PMID 10900153 DOI: 10.1006/Clim.2000.4875  0.316
2000 Sigurdsson EM, Permanne B, Soto C, Wisniewski T, Frangione B. In vivo reversal of amyloid-beta lesions in rat brain. Journal of Neuropathology and Experimental Neurology. 59: 11-7. PMID 10744031 DOI: 10.1093/Jnen/59.1.11  0.404
2000 Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, Lemere CA. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. The American Journal of Pathology. 156: 489-99. PMID 10666378 DOI: 10.1016/S0002-9440(10)64753-0  0.318
2000 Mori C, Wisniewski K, Wisniewski T, Saido TC, Selkoe DJ, Lemere CA. Intraneuronal Aβ42 immunoreactivity is inversely correlated with Alzheimer's disease pathology in down syndrome brain: A temporal study Neurobiology of Aging. 21: 121. DOI: 10.1016/S0197-4580(00)82344-1  0.416
2000 Dowjat WK, Wisniewski T. Alzheimer's disease presenilin-1 regulates assembly of neurofilaments Neurobiology of Aging. 21: 110. DOI: 10.1016/S0197-4580(00)82293-9  0.379
1999 Aucouturier P, Kascsak RJ, Frangione B, Wisniewski T. Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease. Neuroscience Letters. 274: 33-6. PMID 10530513 DOI: 10.1016/S0304-3940(99)00659-X  0.308
1999 Dowjat WK, Wisniewski T, Efthimiopoulos S, Wisniewski HM. Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations. Neuroscience Letters. 267: 141-4. PMID 10400232 DOI: 10.1016/S0304-3940(99)00351-1  0.364
1998 Pomara N, Shao B, Wisniewski T, Mehta PD. Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele. Neurochemical Research. 23: 1563-6. PMID 9821162 DOI: 10.1023/A:1020936222286  0.338
1998 Wisniewski T, Aucouturier P, Soto C, Frangione B. The prionoses and other conformational disorders. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 5: 212-24. PMID 9818059 DOI: 10.3109/13506129809003848  0.464
1998 Wegiel J, Wisniewski HM, Kuchna I, Tarnawski M, Badmajew E, Popovitch E, Kulczycki J, Dowjat WK, Wisniewski T. Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L). Journal of Neuropathology and Experimental Neurology. 57: 831-8. PMID 9737546 DOI: 10.1097/00005072-199809000-00004  0.422
1998 Wisniewski T, Dowjat WK, Buxbaum JD, Khorkova O, Efthimiopoulos S, Kulczycki J, Lojkowska W, Wegiel J, Wisniewski HM, Frangione B. A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years. Neuroreport. 9: 217-21. PMID 9507958 DOI: 10.1097/00001756-199801260-00008  0.356
1997 Wisniewski T, Ghiso J, Frangione B. Biology of A beta amyloid in Alzheimer's disease. Neurobiology of Disease. 4: 313-28. PMID 9440120 DOI: 10.1006/Nbdi.1997.0147  0.387
1997 Permanne B, Perez C, Soto C, Frangione B, Wisniewski T. Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants. Biochemical and Biophysical Research Communications. 240: 715-20. PMID 9398632 DOI: 10.1006/Bbrc.1997.7727  0.458
1997 Wisniewski T, Dowjat WK, Permanne B, Palha J, Kumar A, Gallo G, Frangione B. Presenilin-1 is associated with Alzheimer's disease amyloid. The American Journal of Pathology. 151: 601-10. PMID 9250173  0.345
1997 Ghiso J, Calero M, Matsubara E, Governale S, Chuba J, Beavis R, Wisniewski T, Frangione B. Alzheimer's soluble amyloid beta is a normal component of human urine. Febs Letters. 408: 105-8. PMID 9180278 DOI: 10.1016/S0014-5793(97)00400-6  0.366
1996 Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiology of Disease. 3: 16-32. PMID 9173910 DOI: 10.1006/Nbdi.1996.0003  0.35
1996 Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T. The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid. The Journal of Biological Chemistry. 271: 33623-31. PMID 8969231 DOI: 10.1074/Jbc.271.52.33623  0.404
1996 Garzuly F, Vidal R, Wisniewski T, Brittig F, Budka H. Familial meningocerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTR Asp18Gly) Neurology. 47: 1562-7. PMID 8960746 DOI: 10.1212/Wnl.47.6.1562  0.308
1996 Palha JA, Moreira P, Wisniewski T, Frangione B, Saraiva MJ. Transthyretin gene in Alzheimer's disease patients. Neuroscience Letters. 204: 212-4. PMID 8938268 DOI: 10.1016/0304-3940(96)12334-X  0.444
1996 Frangione B, Castaño EM, Wisniewski T, Ghiso J, Prelli F, Vidal R. Apolipoprotein E and amyloidogenesis. Ciba Foundation Symposium. 199: 132-41; discussion 1. PMID 8915608 DOI: 10.1002/9780470514924.Ch9  0.366
1996 Wisniewski T, Frangione B. Molecular biology of brain aging and neurodegenerative disorders. Acta Neurobiologiae Experimentalis. 56: 267-79. PMID 8787186  0.307
1996 Soto C, Golabek A, Wisniewski T, Castaño EM. Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro. Neuroreport. 7: 721-5. PMID 8733730 DOI: 10.1097/00001756-199602290-00010  0.344
1996 Wisniewski T, Lalowski M, Baumann M, Rauvala H, Raulo E, Nolo R, Frangione B. HB-GAM is a cytokine present in Alzheimer's and Down's syndrome lesions. Neuroreport. 7: 667-71. PMID 8730853 DOI: 10.1097/00001756-199601310-00068  0.413
1996 Golabek AA, Soto C, Vogel T, Wisniewski T. The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation. The Journal of Biological Chemistry. 271: 10602-6. PMID 8631862 DOI: 10.1074/Jbc.271.18.10602  0.441
1996 Baumann MH, Wisniewski T, Levy E, Plant GT, Ghiso J. C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. Biochemical and Biophysical Research Communications. 219: 238-42. PMID 8619814 DOI: 10.1006/Bbrc.1996.0211  0.402
1996 Wisniewski T, Lalowski M, Bobik M, Russell M, Strosznajder J, Frangione B. Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs. The Biochemical Journal. 313: 575-80. PMID 8573095 DOI: 10.1042/Bj3130575  0.359
1996 Golabek AA, Soto C, Wisniewski T. 700 Binding between apolipoprotein E and amyloid β is dependent on secondary structure Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80702-0  0.305
1996 Boksay I, Tchernakov K, Myint Z, Reisberg B, Wisniewski T. 504 Medical conditions in Alzheimer's disease patients with 4/4 isotype of apolipoprotein E Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80506-9  0.325
1995 Wisniewski T, Morelli L, Wegiel J, Levy E, Wisniewski HM, Frangione B. The influence of apolipoprotein E isotypes on Alzheimer's disease pathology in 40 cases of Down's syndrome. Annals of Neurology. 37: 136-8. PMID 7818249 DOI: 10.1002/Ana.410370128  0.345
1995 Ghiso J, Plant GT, Révész T, Wisniewski T, Frangione B. Familial cerebral amyloid angiopathy (British type) with nonneuritic amyloid plaque formation may be due to a novel amyloid protein. Journal of the Neurological Sciences. 129: 74-5. PMID 7751849 DOI: 10.1016/0022-510X(94)00274-R  0.402
1995 Mangone CA, Castaño EM, Levy E, Abiusi G, Wisniewski T, Marques MR, Faccio E, Gorelick PB, Frangione B, Sica RE. Early onset Alzheimer's disease in a South American pedigree from Argentina. Acta Neurologica Scandinavica. 91: 6-13. PMID 7732777 DOI: 10.1111/J.1600-0404.1995.Tb05835.X  0.381
1995 Wisniewski T, Lalowski M, Golabek A, Vogel T, Frangione B. Is Alzheimer's disease an apolipoprotein E amyloidosis? Lancet. 345: 956-8. PMID 7715296 DOI: 10.1016/S0140-6736(95)90701-7  0.411
1995 Wisniewski T, Frangione B. Amyloidosis in Alzheimer's disease. Lancet. 346: 441. PMID 7677907 DOI: 10.1016/S0140-6736(95)92812-X  0.397
1995 Golabek A, Marques MA, Lalowski M, Wisniewski T. Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid. Neuroscience Letters. 191: 79-82. PMID 7659297 DOI: 10.1016/0304-3940(95)11565-7  0.448
1995 Wisniewski T, Golabek AA, Kida E, Wisniewski KE, Frangione B. Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis. The American Journal of Pathology. 147: 238-44. PMID 7639323  0.328
1995 Castano EM, Prelli F, Wisniewski T, Golabek A, Kumar RA, Soto C, Frangione B. Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. The Biochemical Journal. 306: 599-604. PMID 7534068 DOI: 10.1042/Bj3060599  0.436
1995 Wisniewski T, Palha JA, Ghiso J, Frangione B. S182 protein in Alzheimer's disease neuritic plaques. Lancet. 346: 1366. PMID 7475795 DOI: 10.1016/S0140-6736(95)92379-9  0.394
1994 Kida E, Golabek AA, Wisniewski T, Wisniewski KE. Regional differences in apolipoprotein E immunoreactivity in diffuse plaques in Alzheimer's disease brain. Neuroscience Letters. 167: 73-6. PMID 8177532 DOI: 10.1016/0304-3940(94)91030-8  0.384
1994 Wisniewski T, Lalowski M, Levy E, Marques MR, Frangione B. The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient. Annals of Neurology. 35: 245-6. PMID 8109908 DOI: 10.1002/Ana.410350223  0.372
1994 Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. The Journal of Clinical Investigation. 94: 860-9. PMID 8040342 DOI: 10.1172/Jci117407  0.343
1994 Ghiso J, Wisniewski T, Frangione B. Unifying features of systemic and cerebral amyloidosis. Molecular Neurobiology. 8: 49-64. PMID 7916192 DOI: 10.1007/Bf02778007  0.431
1994 Wisniewski T, Ghiso J, Frangione B. Alzheimer's disease and soluble A beta. Neurobiology of Aging. 15: 143-52. PMID 7838284 DOI: 10.1016/0197-4580(94)90105-8  0.475
1994 Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochemical and Biophysical Research Communications. 205: 1431-7. PMID 7802679 DOI: 10.1006/Bbrc.1994.2825  0.341
1994 Frangione B, Wisniewski T, Ghiso J. Chaperoning Alzheimer's amyloids. Neurobiology of Aging. 15: S97-9. PMID 7700474 DOI: 10.1016/0197-4580(94)90182-1  0.435
1993 Wisniewski T, Golabek A, Matsubara E, Ghiso J, Frangione B. Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid. Biochemical and Biophysical Research Communications. 192: 359-65. PMID 8484748 DOI: 10.1006/Bbrc.1993.1423  0.385
1993 Ghiso J, Matsubara E, Koudinov A, Choi-Miura NH, Tomita M, Wisniewski T, Frangione B. The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. The Biochemical Journal. 293: 27-30. PMID 8328966 DOI: 10.1042/Bj2930027  0.357
1993 Wisniewski T, Castano E, Ghiso J, Frangione B. Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro. Annals of Neurology. 34: 631-3. PMID 8215255 DOI: 10.1002/Ana.410340422  0.352
1993 Rodrigues MM, Rajagopalan S, Jones K, Nirankari V, Wisniewski T, Frangione B, Gorevic PD. Gelsolin immunoreactivity in corneal amyloid, wound healing, and macular and granular dystrophies. American Journal of Ophthalmology. 115: 644-52. PMID 7683843 DOI: 10.1016/S0002-9394(14)71464-3  0.355
1992 Wisniewski T, Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neuroscience Letters. 135: 235-8. PMID 1625800 DOI: 10.1016/0304-3940(92)90444-C  0.372
1992 Wisniewski T, Frangione B. Molecular biology of Alzheimer's amyloid--Dutch variant. Molecular Neurobiology. 6: 75-86. PMID 1463589 DOI: 10.1007/Bf02935567  0.418
1992 Ghiso J, Wisniewski T, Vidal R, Rostagno A, Frangione B. Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease. The Biochemical Journal. 282: 517-22. PMID 1372166 DOI: 10.1042/Bj2820517  0.383
1991 Castaño EM, Wisniewski T, Frangione B. Inherited amyloids of the nervous system. Current Opinion in Neurobiology. 1: 448-54. PMID 1821690 DOI: 10.1016/0959-4388(91)90068-I  0.426
1991 Wisniewski T, Ghiso J, Frangione B. Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation. Biochemical and Biophysical Research Communications. 179: 1247-54. PMID 1681804 DOI: 10.1016/0006-291X(91)91706-I  0.45
1991 Haltia M, Ghiso J, Wisniewski T, Kiuru S, Miller D, Frangione B. Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies. Neurobiology of Aging. 12: 313-6. PMID 1660109 DOI: 10.1016/0197-4580(91)90007-7  0.395
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