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Todd N. Eagar, Ph.D. - Publications

Affiliations: 
2002 Northwestern University, Evanston, IL 
Area:
Molecular Neuroscience, Neurobiology of Disease, Neuroimmunology
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Vasileiou S, Hill L, Kuvalekar M, Workineh AG, Watanabe A, Velazquez Y, Lulla S, Mooney K, Lapteva N, Grilley BJ, Heslop HE, Rooney CM, Brenner MK, Eagar TN, Carrum G, et al. Allogeneic, Off-the-Shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high risk patients. Haematologica. PMID 36373249 DOI: 10.3324/haematol.2022.281946  0.366
2021 Manouchehri N, Hussain RZ, Cravens PD, Esaulova E, Artyomov MN, Edelson BT, Wu GF, Cross AH, Doelger R, Loof N, Eagar TN, Forsthuber TG, Calvier L, Herz J, Stüve O. CD11cCD88CD317 myeloid cells are critical mediators of persistent CNS autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33785592 DOI: 10.1073/pnas.2014492118  0.31
2019 Hussain RZ, Cravens PD, Miller-Little WA, Doelger R, Granados V, Herndon E, Okuda DT, Eagar TN, Stüve O. α4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model. Neurology(R) Neuroimmunology & Neuroinflammation. 6: e563. PMID 31086806 DOI: 10.1212/Nxi.0000000000000563  0.489
2019 Kim TO, Greenwood M, Eagar T, Despotovic JM. Novel HLA Typing Method Identifies HLA Alleles Associated with Pediatric ITP Blood. 134: 1067-1067. DOI: 10.1182/Blood-2019-129235  0.331
2018 Cummings M, Arumanayagam ACS, Zhao P, Kannanganat S, Stuve O, Karandikar NJ, Eagar TN. Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis. Plos One. 13: e0200752. PMID 30089166 DOI: 10.1371/Journal.Pone.0200752  0.48
2016 Arellano B, Hussain R, Miller-Little WA, Herndon E, Lambracht-Washington D, Eagar TN, Lewis R, Healey D, Vernino S, Greenberg BM, Stüve O. A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR. Plos One. 11: e0152720. PMID 27054574 DOI: 10.1371/Journal.Pone.0152720  0.433
2015 Raphael I, Nalawade S, Eagar TN, Forsthuber TG. T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine. 74: 5-17. PMID 25458968 DOI: 10.1016/J.Cyto.2014.09.011  0.392
2015 Salazar E, Eagar TN, Land GA. LBP33 Human Immunology. 76: 236. DOI: 10.1016/J.Humimm.2015.01.065  0.306
2014 Hussain RZ, Hayardeny L, Cravens PC, Yarovinsky F, Eagar TN, Arellano B, Deason K, Castro-Rojas C, Stüve O. Immune surveillance of the central nervous system in multiple sclerosis--relevance for therapy and experimental models. Journal of Neuroimmunology. 276: 9-17. PMID 25282087 DOI: 10.1016/J.Jneuroim.2014.08.622  0.382
2014 Castro-Rojas C, Deason K, Hussain RZ, Hayardeny L, Cravens PC, Yarovinsky F, Eagar TN, Arellano B, Stüve O. Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance. Journal of Neuroimmunology. 276: 232-5. PMID 25227585 DOI: 10.1016/J.Jneuroim.2014.08.624  0.34
2013 Lambracht-Washington D, Qu BX, Fu M, Anderson LD, Eagar TN, Stüve O, Rosenberg RN. A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Aβ42 DNA vaccine for Alzheimer disease. Journal of Neuroimmunology. 254: 63-8. PMID 23036592 DOI: 10.1016/J.Jneuroim.2012.09.008  0.411
2012 Eagar TN, Miller SD. Helper T-cell subsets and control of the inflammatory response Clinical Immunology: Principles and Practice: Fourth Edition. 203-214. DOI: 10.1016/B978-0-7234-3691-1.00014-3  0.465
2011 Cravens PD, Hussain RZ, Zacharias TE, Ben LH, Herndon E, Vinnakota R, Lambracht-Washington D, Nessler S, Zamvil SS, Eagar TN, Stüve O. Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet. Journal of Neuroinflammation. 8: 73. PMID 21702922 DOI: 10.1186/1742-2094-8-73  0.466
2011 Lambracht-Washington D, Qu BX, Fu M, Anderson LD, Stüve O, Eagar TN, Rosenberg RN. DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation. Cellular and Molecular Neurobiology. 31: 867-74. PMID 21625960 DOI: 10.1007/S10571-011-9680-7  0.39
2011 Monson NL, Cravens P, Hussain R, Harp CT, Cummings M, de Pilar Martin M, Ben LH, Do J, Lyons JA, Lovette-Racke A, Cross AH, Racke MK, Stüve O, Shlomchik M, Eagar TN. Rituximab therapy reduces organ-specific T cell responses and ameliorates experimental autoimmune encephalomyelitis. Plos One. 6: e17103. PMID 21359213 DOI: 10.1371/Journal.Pone.0017103  0.503
2011 Lambracht-Washington D, Qu B, Fu M, Eagar TN, Stuve O, Rosenberg RN. P2-470: T cell responses after DNA Abeta-42 trimer immunization in mice indicate the potential for safe immunotherapy for Alzheimer's disease Alzheimer's & Dementia. 7: S463-S463. DOI: 10.1016/J.Jalz.2011.05.1342  0.407
2010 Harp CT, Ireland S, Davis LS, Remington G, Cassidy B, Cravens PD, Stuve O, Lovett-Racke AE, Eagar TN, Greenberg BM, Racke MK, Cowell LG, Karandikar NJ, Frohman EM, Monson NL. Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein. European Journal of Immunology. 40: 2942-56. PMID 20812237 DOI: 10.1002/Eji.201040516  0.438
2010 Stüve O, Kieseier BC, Hemmer B, Hartung HP, Awad A, Frohman EM, Greenberg BM, Racke MK, Zamvil SS, Phillips JT, Gold R, Chan A, Zettl U, Milo R, Marder E, ... ... Eagar TN, et al. Translational research in neurology and neuroscience 2010: multiple sclerosis. Archives of Neurology. 67: 1307-15. PMID 20625066 DOI: 10.1001/Archneurol.2010.158  0.344
2010 Hu W, Nessler S, Hemmer B, Eagar TN, Kane LP, Leliveld SR, Müller-Schiffmann A, Gocke AR, Lovett-Racke A, Ben LH, Hussain RZ, Breil A, Elliott JL, Puttaparthi K, Cravens PD, et al. Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling. Brain : a Journal of Neurology. 133: 375-88. PMID 20145049 DOI: 10.1093/Brain/Awp298  0.455
2010 Ortega S, Tyler A, York N, Mendoza J, Firan M, Benagh A, Eagar T, Karandikar N. Inhibition of Autoimmune Demyelinating Disease by Neuroantigen-specific, Autoreactive CD8+ T Cells Clinical Immunology. 135: S8. DOI: 10.1016/J.Clim.2010.03.030  0.478
2009 Lambracht-Washington D, Qu BX, Fu M, Eagar TN, Stüve O, Rosenberg RN. DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model. Jama. 302: 1796-802. PMID 19861672 DOI: 10.1001/Jama.2009.1547  0.369
2009 Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nature Immunology. 10: 1185-92. PMID 19783989 DOI: 10.1038/Ni.1790  0.342
2009 Hussain RZ, Hopkins SC, Frohman EM, Eagar TN, Cravens PC, Greenberg BM, Vernino S, Stüve O. Direct and consensual murine pupillary reflex metrics: establishing normative values. Autonomic Neuroscience : Basic & Clinical. 151: 164-7. PMID 19683968 DOI: 10.1016/J.Autneu.2009.07.021  0.329
2009 Martin Mdel P, Cravens PD, Winger R, Kieseier BC, Cepok S, Eagar TN, Zamvil SS, Weber MS, Frohman EM, Kleinschmidt-Demasters BK, Montine TJ, Hemmer B, Marra CM, Stüve O. Depletion of B lymphocytes from cerebral perivascular spaces by rituximab. Archives of Neurology. 66: 1016-20. PMID 19667224 DOI: 10.1001/Archneurol.2009.157  0.366
2009 Hu W, Metselaar J, Ben LH, Cravens PD, Singh MP, Frohman EM, Eagar TN, Racke MK, Kieseier BC, Stüve O. PEG minocycline-liposomes ameliorate CNS autoimmune disease. Plos One. 4: e4151. PMID 19127301 DOI: 10.1371/Journal.Pone.0004151  0.367
2009 Singh MP, Hörste GMz, Hu W, Mausberg AK, Cravens PD, Eagar T, Löber S, Klingenstein R, Gmeiner P, Korth C, Kieseier BC, Stüve O. Quinpramine is a novel compound effective in ameliorating brain autoimmune disease Experimental Neurology. 215: 397-400. PMID 18996373 DOI: 10.1016/J.Expneurol.2008.10.001  0.408
2008 Frohman EM, Eagar T, Monson N, Stuve O, Karandikar N. Immunologic Mechanisms of Multiple Sclerosis Neuroimaging Clinics of North America. 18: 577-588. PMID 19068403 DOI: 10.1016/J.Nic.2008.06.009  0.343
2008 Stüve O, Eagar TN. B cells, antibodies, and tertiary lymphoid tissue in MS brains. The Lancet. Neurology. 7: 766-7. PMID 18702996 DOI: 10.1016/S1474-4422(08)70176-5  0.315
2008 Stüve O, Cravens PD, Eagar TN. DNA-based vaccines: the future of multiple sclerosis therapy? Expert Review of Neurotherapeutics. 8: 351-60. PMID 18345967 DOI: 10.1586/14737175.8.3.351  0.49
2006 Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. The Journal of Experimental Medicine. 203: 2737-47. PMID 17116737 DOI: 10.1084/Jem.20061577  0.32
2005 Smith CE, Eagar TN, Strominger JL, Miller SD. Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 102: 9595-600. PMID 15983366 DOI: 10.1073/Pnas.0504131102  0.68
2004 Eagar TN, Turley DM, Padilla J, Karandikar NJ, Tan L, Bluestone JA, Miller SD. CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance. Journal of Immunology (Baltimore, Md. : 1950). 172: 7442-50. PMID 15187122 DOI: 10.4049/Jimmunol.172.12.7442  0.707
2004 Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA. Notch 1 signaling regulates peripheral T cell activation. Immunity. 20: 407-15. PMID 15084270 DOI: 10.1016/S1074-7613(04)00081-0  0.393
2002 Olson JK, Eagar TN, Miller SD. Functional activation of myelin-specific T cells by virus-induced molecular mimicry. Journal of Immunology (Baltimore, Md. : 1950). 169: 2719-26. PMID 12193746 DOI: 10.4049/Jimmunol.169.5.2719  0.604
2002 Eagar TN, Karandikar NJ, Bluestone JA, Miller SD. The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. European Journal of Immunology. 32: 972-81. PMID 11920563 DOI: 10.1002/1521-4141(200204)32:4<972::Aid-Immu972>3.0.Co;2-M  0.601
2001 Miller SD, Eagar TN. Functional role of epitope spreading in the chronic pathogenesis of autoimmune and virus-induced demyelinating diseases. Advances in Experimental Medicine and Biology. 490: 99-107. PMID 11505979 DOI: 10.1007/978-1-4615-1243-1_10  0.641
2001 Theien BE, Vanderlugt CL, Eagar TN, Nickerson-Nutter C, Nazareno R, Kuchroo VK, Miller SD. Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. The Journal of Clinical Investigation. 107: 995-1006. PMID 11306603 DOI: 10.1172/Jci11717  0.647
2000 Karandikar NJ, Eagar TN, Vanderlugt CL, Bluestone JA, Miller SD. CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 109: 173-80. PMID 10996219 DOI: 10.1016/S0165-5728(00)00322-2  0.622
2000 Vanderlugt CL, Neville KL, Nikcevich KM, Eagar TN, Bluestone JA, Miller SD. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 164: 670-8. PMID 10623809 DOI: 10.4049/Jimmunol.164.2.670  0.749
1998 Vanderlugt CL, Begolka WS, Neville KL, Katz-Levy Y, Howard LM, Eagar TN, Bluestone JA, Miller SD. The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunological Reviews. 164: 63-72. PMID 9795764 DOI: 10.1111/J.1600-065X.1998.Tb01208.X  0.745
1998 Eagar T, Karanolikar N, Tan L, Lee H, Barrett T, Bluestone J, Miller S. Tolerance in EAE: A central role for CTLA-4 Journal of Neuroimmunology. 90: 81. DOI: 10.1016/S0165-5728(98)91662-9  0.468
1998 Eagar T, Tan LJ, Leg H, Barrett T, Miller SD. Activation of antigen-specific T cells in vivo induced by tolerogenic encounter with antigen-coupled splenocytes Faseb Journal. 12: A624.  0.409
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